Senthil K. Muthuswamy - Publications

Affiliations: 
Stony Brook University, Stony Brook, NY, United States 
Area:
Cell Biology

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, ... ... Muthuswamy SK, et al. Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. Plos Biology. 16: e2004049. PMID 29924804 DOI: 10.1371/journal.pbio.2004049  0.44
2016 Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK. An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function. Nature Cell Biology. PMID 27694890 DOI: 10.1038/ncb3413  0.44
2016 Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. Development (Cambridge, England). 143: e1.1. PMID 27381229 DOI: 10.1242/dev.141093  0.44
2016 Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. SCRIBBLE is required for pregnancy-induced alveologenesis in the adult mammary gland. Journal of Cell Science. PMID 27179074 DOI: 10.1242/jcs.185413  0.44
2016 Milano DF, Ngai NA, Muthuswamy SK, Asthagiri AR. Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement. Biophysical Journal. 110: 1886-95. PMID 27119647 DOI: 10.1016/j.bpj.2016.02.040  0.44
2015 Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, ... ... Muthuswamy SK, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nature Medicine. PMID 26501191 DOI: 10.1038/nm.3973  0.44
2015 Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. The Journal of Biological Chemistry. 290: 9646-59. PMID 25681440 DOI: 10.1074/jbc.M114.627968  0.44
2014 Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology. 10: 558-66. PMID 24845231 DOI: 10.1038/nchembio.1528  0.44
2014 Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK. Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Research. 74: 3180-94. PMID 24662921 DOI: 10.1158/0008-5472.CAN-13-3415  0.44
2014 Feigin ME, Xue B, Hammell MC, Muthuswamy SK. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proceedings of the National Academy of Sciences of the United States of America. 111: 4191-6. PMID 24599592 DOI: 10.1073/pnas.1320239111  0.44
2013 Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature Cell Biology. 15: 189-200. PMID 23263278 DOI: 10.1038/ncb2663  0.44
2012 Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Molecular Cell. 47: 469-83. PMID 22883624 DOI: 10.1016/j.molcel.2012.06.037  0.44
2012 Muthuswamy SK, Xue B. Cell polarity as a regulator of cancer cell behavior plasticity. Annual Review of Cell and Developmental Biology. 28: 599-625. PMID 22881459 DOI: 10.1146/annurev-cellbio-092910-154244  0.44
2012 Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. Plos One. 7: e34343. PMID 22529912 DOI: 10.1371/journal.pone.0034343  0.44
2012 Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural & Molecular Biology. 19: 220-8. PMID 22245967 DOI: 10.1038/nsmb.2207  0.44
2011 Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Research. 71: 3822-30. PMID 21610111 DOI: 10.1158/0008-5472.CAN-10-3782  0.44
2011 Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA. ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell. 8: 164-76. PMID 21295273 DOI: 10.1016/j.stem.2010.12.009  0.44
2010 Cabodi S, Tinnirello A, Bisaro B, Tornillo G, Camacho-Leal MDP, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, et al. p130Cas is an essential transducer element in ErbB2 transformation Faseb Journal. 24: 3796-3808. PMID 20505116 DOI: 10.1096/fj.10-157347  0.44
2009 Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Current Opinion in Cell Biology. 21: 694-700. PMID 19729289 DOI: 10.1016/j.ceb.2009.07.003  0.44
2009 Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 137: 1047-61. PMID 19524508 DOI: 10.1016/j.cell.2009.04.013  0.44
2009 Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Experimental Cell Research. 315: 707-16. PMID 19022245 DOI: 10.1016/j.yexcr.2008.10.034  0.44
2008 Zavadil J, Haley J, Kalluri R, Muthuswamy SK, Thompson E. Epithelial-mesenchymal transition. Cancer Research. 68: 9574-7. PMID 19047131 DOI: 10.1158/0008-5472.CAN-08-2316  0.44
2008 Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 135: 865-78. PMID 19041750 DOI: 10.1016/j.cell.2008.09.045  0.44
2008 Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 12463-8. PMID 18719096 DOI: 10.1073/pnas.0805009105  0.44
2007 Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes & Development. 21: 3238-43. PMID 18079172 DOI: 10.1101/gad.1616307  0.44
2006 Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature Cell Biology. 8: 1235-45. PMID 17060907 DOI: 10.1038/ncb1485  0.44
2006 Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 10: 25-38. PMID 16843263 DOI: 10.1016/j.ccr.2006.05.023  0.44
2006 Zhan L, Xiang B, Muthuswamy SK. Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Research. 66: 5201-8. PMID 16707444 DOI: 10.1158/0008-5472.CAN-05-4081  0.44
2006 Xiang B, Muthuswamy SK. Using three-dimensional acinar structures for molecular and cell biological assays. Methods in Enzymology. 406: 692-701. PMID 16472698 DOI: 10.1016/S0076-6879(06)06054-X  0.44
2005 Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Molecular and Cellular Biology. 25: 4591-601. PMID 15899862 DOI: 10.1128/MCB.25.11.4591-4601.2005  0.44
2004 Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Molecular and Cellular Biology. 24: 8586-99. PMID 15367678 DOI: 10.1128/MCB.24.19.8586-8599.2004  0.44
2004 Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 1257-62. PMID 14739340 DOI: 10.1073/pnas.0308090100  0.44
2003 Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nature Cell Biology. 5: 733-40. PMID 12844146 DOI: 10.1038/ncb1026  0.44
2003 Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (San Diego, Calif.). 30: 256-68. PMID 12798140 DOI: 10.1016/S1046-2023(03)00032-X  0.44
2002 Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 111: 29-40. PMID 12372298 DOI: 10.1016/S0092-8674(02)01001-2  0.44
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