Jonathan Chernoff - Publications

1991- ICR Fox Chase Cancer Center, Philadelphia 
Molecular Biology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cannon AC, Uribe-Alvarez C, Chernoff J. RAC1 as a Therapeutic Target in Malignant Melanoma. Trends in Cancer. 6: 478-488. PMID 32460002 DOI: 10.1016/j.trecan.2020.02.021  0.72
2020 Kurimchak AM, Herrera-Montávez C, Brown J, Johnson KJ, Sodi V, Srivastava N, Kumar V, Deihimi S, O'Brien S, Peri S, Mantia-Smaldone GM, Jain A, Winters RM, Cai KQ, Chernoff J, et al. Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. Science Signaling. 13. PMID 32071169 DOI: 10.1126/scisignal.aax8238  0.72
2020 Uribe-Alvarez C, Guerrero-Rodríguez SL, Rhodes J, Cannon A, Chernoff J, Araiza-Olivera D. Targeting effector pathways in RAC1-driven malignant melanoma. Small Gtpases. 1-9. PMID 32043900 DOI: 10.1080/21541248.2020.1728469  0.8
2020 Benton D, Chernoff J. A New Rho(d) Map to Diffuse Gastric Cancer. Cancer Discovery. 10: 182-184. PMID 32024682 DOI: 10.1158/2159-8290.CD-19-1327  0.64
2019 Shen YC, Arellano-Garcia C, Menjivar RE, Jewett EM, Dohle W, Karchugina S, Chernoff J, Potter BVL, Barald KF. Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2). Bmc Pharmacology & Toxicology. 20: 67. PMID 31730023 DOI: 10.1186/s40360-019-0369-8  1
2019 Binder P, Wang S, Radu M, Zi M, Collins L, Khan S, Li Y, Sekeres K, Humphreys NE, Swanton E, Reid A, Pu F, Oceandy D, Guan K, Hille S, ... ... Chernoff J, et al. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circulation Research. PMID 30620686 DOI: 10.1161/CIRCRESAHA.118.312829  0.6
2018 Karchugina S, Chernoff J. Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay. Journal of Visualized Experiments : Jove. PMID 30394375 DOI: 10.3791/57755  1
2018 Stepanova DS, Braun L, Chernoff J. A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis. Oncoscience. 5: 126-127. PMID 30035161 DOI: 10.18632/oncoscience.417  0.56
2017 Stepanova DS, Semenova G, Kuo YM, Andrews AJ, Ammoun S, Hanemann CO, Chernoff J. An essential role for the tumor suppressor Merlin in regulating fatty acid synthesis. Cancer Research. PMID 28729415 DOI: 10.1158/0008-5472.CAN-16-2834  1
2017 Radu M, Chernoff J. Recent advances in methods to assess the activity of the kinome. F1000research. 6: 1004. PMID 28713564 DOI: 10.12688/f1000research.10962.1  0.6
2017 Semenova G, Chernoff J. Targeting PAK1. Biochemical Society Transactions. 45: 79-88. PMID 28202661 DOI: 10.1042/BST20160134  1
2017 Semenova G, Stepanova D, Deyev SM, Chernoff J. Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type I. Biochimie. PMID 28065690 DOI: 10.1016/j.biochi.2017.01.001  1
2016 Joseph GA, Lu M, Radu M, Lee JK, Burden SJ, Chernoff J, Krauss RS. Group I Paks promote skeletal myoblast differentiation in vivo and in vitro. Molecular and Cellular Biology. PMID 27920252 DOI: 10.1128/MCB.00222-16  0.6
2016 Villamar Cruz O, Prudnikova TY, Araiza-Olivera D, Perez-Plasencia C, Johnson N, Bernhardy AJ, Slifker M, Renner C, Chernoff J, Arias-Romero LE. Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. Oncotarget. PMID 27740936 DOI: 10.18632/oncotarget.12576  0.72
2016 Araiza-Olivera D, Chernoff J. HRAs helps hippo heterodimerize to evade tumor suppression. Small Gtpases. 0. PMID 27560370 DOI: 10.1080/21541248.2016.1228794  0.72
2016 Kurimchak AM, Shelton C, Duncan KE, Johnson KJ, Brown J, O'Brien S, Gabbasov R, Fink LS, Li Y, Lounsbury N, Abou-Gharbia M, Childers WE, Connolly DC, Chernoff J, Peterson JR, et al. Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. Cell Reports. PMID 27452461 DOI: 10.1016/j.celrep.2016.06.091  0.44
2016 Prudnikova TY, Chernoff J. The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. Small Gtpases. 0. PMID 27427770 DOI: 10.1080/21541248.2016.1213089  0.72
2016 Rawat SJ, Araiza-Olivera D, Arias-Romero LE, Villamar-Cruz O, Prudnikova TY, Roder H, Chernoff J. H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization. Current Biology : Cb. PMID 27238285 DOI: 10.1016/j.cub.2016.04.027  0.96
2016 Reddy PN, Radu M, Xu K, Wood J, Harris CE, Chernoff J, Williams DA. p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood. 127: 1967-75. PMID 26932803 DOI: 10.1182/blood-2016-01-693572  0.6
2016 Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene. 35: 2178-85. PMID 26257058 DOI: 10.1038/onc.2015.278  1
2015 Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J. p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway. Molecular and Cellular Biology. 35: 3990-4005. PMID 26391956 DOI: 10.1128/MCB.00630-15  0.96
2015 Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. PMID 26170031 DOI: 10.1182/blood-2014-12-618801  0.96
2015 O'Hagan KL, Choi J, Pryshchep O, Chernoff J, Phee H. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. Journal of Immunology (Baltimore, Md. : 1950). 195: 1564-77. PMID 26157175 DOI: 10.4049/jimmunol.1500843  0.96
2015 Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L, Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, ... ... Chernoff J, et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Research : Bcr. 17: 59. PMID 25902869 DOI: 10.1186/s13058-015-0564-5  0.96
2015 Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 125: 2995-3005. PMID 25824689 DOI: 10.1182/blood-2014-10-604504  0.72
2015 Rawat SJ, Chernoff J. Regulation of mammalian Ste20 (Mst) kinases. Trends in Biochemical Sciences. 40: 149-56. PMID 25665457 DOI: 10.1016/j.tibs.2015.01.001  1
2015 Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 6: 1981-94. PMID 25596744  0.96
2015 Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, et al. Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells (Dayton, Ohio). 33: 1630-41. PMID 25586960 DOI: 10.1002/stem.1951  0.96
2015 Prudnikova TY, Rawat SJ, Chernoff J. Molecular pathways: targeting the kinase effectors of RHO-family GTPases. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 24-9. PMID 25336694 DOI: 10.1158/1078-0432.CCR-14-0827  1
2015 Badolia R, Manne BK, Dangelmaier C, Chernoff J, Kunapuli SP. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood. 125: 175-84. PMID 25331114 DOI: 10.1182/blood-2014-05-576306  0.96
2014 Elsherif L, Ozler M, Zayed MA, Shen JH, Chernoff J, Faber JE, Parise LV. Potential compensation among group I PAK members in hindlimb ischemia and wound healing. Plos One. 9: e112239. PMID 25379771 DOI: 10.1371/journal.pone.0112239  0.96
2014 Baker NM, Yee Chow H, Chernoff J, Der CJ. Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4740-6. PMID 25225063 DOI: 10.1158/1078-0432.CCR-13-1727  0.96
2014 Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 3: e02270. PMID 24843022 DOI: 10.7554/eLife.02270  0.96
2014 Kelly ML, Astsaturov A, Rhodes J, Chernoff J. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Developmental Cell. 29: 350-9. PMID 24823378 DOI: 10.1016/j.devcel.2014.04.003  0.96
2014 Radu M, Semenova G, Kosoff R, Chernoff J. PAK signalling during the development and progression of cancer. Nature Reviews. Cancer. 14: 13-25. PMID 24505617  1
2013 Rudolph J, Crawford JJ, Hoeflich KP, Chernoff J. p21-activated kinase inhibitors. The Enzymes. 34: 157-80. PMID 25034104 DOI: 10.1016/B978-0-12-420146-0.00007-X  0.96
2013 Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. Plos One. 8: e73063. PMID 24019894 DOI: 10.1371/journal.pone.0073063  0.96
2013 Licciulli S, Maksimoska J, Zhou C, Troutman S, Kota S, Liu Q, Duron S, Campbell D, Chernoff J, Field J, Marmorstein R, Kissil JL. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. The Journal of Biological Chemistry. 288: 29105-14. PMID 23960073 DOI: 10.1074/jbc.M113.510933  0.96
2013 Arias-Romero LE, Chernoff J. Targeting Cdc42 in cancer. Expert Opinion On Therapeutic Targets. 17: 1263-73. PMID 23957315 DOI: 10.1517/14728222.2013.828037  0.56
2013 Aslan JE, Baker SM, Loren CP, Haley KM, Itakura A, Pang J, Greenberg DL, David LL, Manser E, Chernoff J, McCarty OJ. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. American Journal of Physiology. Cell Physiology. 305: C519-28. PMID 23784547 DOI: 10.1152/ajpcell.00418.2012  0.96
2013 Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA, Chernoff J. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. The Journal of Biological Chemistry. 288: 21117-25. PMID 23760270 DOI: 10.1074/jbc.M113.459719  0.96
2013 Kelly ML, Astsaturov A, Chernoff J. Role of p21-activated kinases in cardiovascular development and function. Cellular and Molecular Life Sciences : Cmls. 70: 4223-8. PMID 23640572 DOI: 10.1007/s00018-013-1347-8  0.96
2013 Aslan JE, Itakura A, Haley KM, Tormoen GW, Loren CP, Baker SM, Pang J, Chernoff J, McCarty OJ. p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1544-51. PMID 23640496 DOI: 10.1161/ATVBAHA.112.301165  0.96
2013 Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J. Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Research. 73: 3671-82. PMID 23576562 DOI: 10.1158/0008-5472.CAN-12-4453  0.96
2013 Radu M, Chernoff J. An in vivo assay to test blood vessel permeability. Journal of Visualized Experiments : Jove. e50062. PMID 23524912 DOI: 10.3791/50062  0.6
2013 Rawat SJ, Creasy CL, Peterson JR, Chernoff J. The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. The Journal of Biological Chemistry. 288: 8762-71. PMID 23386615 DOI: 10.1074/jbc.M112.414524  1
2013 Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 121: 2474-82. PMID 23335370 DOI: 10.1182/blood-2012-10-460709  0.88
2013 Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H. p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways American Journal of Physiology - Gastrointestinal and Liver Physiology. 304: G561-G567. PMID 23306081 DOI: 10.1152/ajpgi.00218.2012  0.96
2013 Kosoff R, Chow HY, Radu M, Chernoff J. Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. The Journal of Biological Chemistry. 288: 974-83. PMID 23204526 DOI: 10.1074/jbc.M112.422295  0.88
2012 Kelly ML, Chernoff J. Mouse models of PAK function. Cellular Logistics. 2: 84-88. PMID 23162740 DOI: 10.4161/cl.21381  0.96
2012 Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Research. 72: 5966-75. PMID 22983922 DOI: 10.1158/0008-5472.CAN-12-2246  0.96
2012 Hoover WC, Zhang W, Xue Z, Gao H, Chernoff J, Clapp DW, Gunst SJ, Tepper RS. Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. Plos One. 7: e42601. PMID 22900031 DOI: 10.1371/journal.pone.0042601  0.96
2012 Menges CW, Sementino E, Talarchek J, Xu J, Chernoff J, Peterson JR, Testa JR. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Molecular Cancer Research : McR. 10: 1178-88. PMID 22798428 DOI: 10.1158/1541-7786.MCR-12-0082  0.44
2012 Semenova G, Chernoff J. PKM2 enters the morpheein academy. Molecular Cell. 45: 583-4. PMID 22405271 DOI: 10.1016/j.molcel.2012.02.014  1
2012 Monasky MM, Taglieri DM, Patel BG, Chernoff J, Wolska BM, Ke Y, Solaro RJ. p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. American Journal of Physiology. Heart and Circulatory Physiology. 302: H224-30. PMID 22037191 DOI: 10.1152/ajpheart.00612.2011  0.96
2011 Taglieri DM, Monasky MM, Knezevic I, Sheehan KA, Lei M, Wang X, Chernoff J, Wolska BM, Ke Y, Solaro RJ. Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. Journal of Molecular and Cellular Cardiology. 51: 988-96. PMID 21971074 DOI: 10.1016/j.yjmcc.2011.09.016  0.96
2011 Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC. Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. The Journal of Biological Chemistry. 286: 41359-67. PMID 21969371 DOI: 10.1074/jbc.M111.291500  0.96
2011 Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell. 21: 722-34. PMID 21924960 DOI: 10.1016/j.devcel.2011.07.008  0.96
2011 Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, et al. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells Embo Journal. 30: 3160-3172. PMID 21725281 DOI: 10.1038/emboj.2011.213  0.96
2011 Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM. Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. The Journal of Cell Biology. 193: 1289-303. PMID 21708980 DOI: 10.1083/jcb.201010059  0.96
2011 Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, et al. Back to the future: proceedings from the 2010 NF Conference. American Journal of Medical Genetics. Part A. 155: 307-21. PMID 21271647 DOI: 10.1002/ajmg.a.33804  0.96
2011 Kelly ML, Chernoff J. Getting smart about p21-activated kinases. Molecular and Cellular Biology. 31: 386-7. PMID 21115726 DOI: 10.1128/MCB.01267-10  0.96
2011 Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. Bju International. 108: E84-90. PMID 21050361 DOI: 10.1111/j.1464-410X.2010.09844.x  0.96
2010 Arias-Romero LE, Chernoff J. p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small Gtpases. 1: 124-128. PMID 21686266 DOI: 10.4161/sgtp.1.2.14109  0.56
2010 Chow HY, Stepanova D, Koch J, Chernoff J. p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. Plos One. 5: e13791. PMID 21072183 DOI: 10.1371/journal.pone.0013791  0.96
2010 Kosoff R, Chernoff J. LOV conquers (sm)All GTPases. F1000 Biology Reports. 2. PMID 20948805 DOI: 10.3410/B2-28  0.88
2010 Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 29: 5839-49. PMID 20711231 DOI: 10.1038/onc.2010.318  0.88
2010 Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. The Journal of Cell Biology. 190: 101-14. PMID 20603326 DOI: 10.1083/jcb.200908050  0.96
2010 Van den Broeke C, Radu M, Chernoff J, Favoreel HW. An emerging role for p21-activated kinases (Paks) in viral infections. Trends in Cell Biology. 20: 160-9. PMID 20071173 DOI: 10.1016/j.tcb.2009.12.005  0.6
2010 Pacheco A, Chernoff J. Group I p21-activated kinases: Emerging roles in immune function and viral pathogenesis International Journal of Biochemistry and Cell Biology. 42: 13-16. PMID 19747561 DOI: 10.1016/j.biocel.2009.09.006  0.96
2009 Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Plos One. 4: e6025. PMID 19557173 DOI: 10.1371/journal.pone.0006025  0.56
2009 Radu M, Chernoff J. The DeMSTification of mammalian Ste20 kinases. Current Biology : Cb. 19: R421-5. PMID 19467213 DOI: 10.1016/j.cub.2009.04.022  0.6
2009 Arias-Romero LE, Saha S, Villamar-Cruz O, Yip SC, Ethier SP, Zhang ZY, Chernoff J. Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Research. 69: 4582-8. PMID 19435911 DOI: 10.1158/0008-5472.CAN-08-4001  0.72
2009 Van den Broeke C, Radu M, Deruelle M, Nauwynck H, Hofmann C, Jaffer ZM, Chernoff J, Favoreel HW. Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proceedings of the National Academy of Sciences of the United States of America. 106: 8707-12. PMID 19435845 DOI: 10.1073/pnas.0900436106  0.96
2009 Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Experimental Neurology. 218: 137-44. PMID 19409384 DOI: 10.1016/j.expneurol.2009.04.019  0.44
2009 Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, Chen S, Derr-Yellin E, Michels EG, McDaniel A, Bessler WK, Ingram DA, Atkinson SJ, Travers JB, Chernoff J, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood. 113: 2695-705. PMID 19124833 DOI: 10.1182/blood-2008-06-160861  0.96
2008 Smith SD, Jaffer ZM, Chernoff J, Ridley AJ. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. Journal of Cell Science. 121: 3729-36. PMID 18940914 DOI: 10.1242/jcs.027680  0.96
2008 McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, Chen S, Bessler WK, Hofmann C, Ingram DA, Chernoff J, Clapp DW. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood. 112: 4646-54. PMID 18768391 DOI: 10.1182/blood-2008-04-155085  0.96
2008 Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chemistry & Biology. 15: 322-31. PMID 18420139 DOI: 10.1016/j.chembiol.2008.03.005  0.44
2008 Arias-Romero LE, Chernoff J. A tale of two Paks. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 100: 97-108. PMID 18199048 DOI: 10.1042/BC20070109  0.56
2008 Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Journal of Molecular and Cellular Cardiology. 44: 429-34. PMID 18054038 DOI: 10.1016/j.yjmcc.2007.10.016  0.96
2007 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/jcs.03484  0.96
2007 Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of Biological Chemistry. 282: 15667-78. PMID 17392278 DOI: 10.1074/jbc.M700253200  0.96
2007 Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, Chernoff J. Regulation of protein tyrosine phosphatase 1B by sumoylation Nature Cell Biology. 9: 80-85. PMID 17159996 DOI: 10.1038/ncb1522  0.96
2006 Peterson JR, Chernoff J. Src transforms in a Cool way. Nature Cell Biology. 8: 905-7. PMID 16946737 DOI: 10.1038/ncb0906-905  0.96
2006 Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, Kuriyan J. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. Journal of Molecular Biology. 361: 312-26. PMID 16837009 DOI: 10.1016/j.jmb.2006.06.017  0.96
2006 ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL. Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. The Journal of Cell Biology. 172: 759-69. PMID 16492808 DOI: 10.1083/jcb.200509096  0.96
2005 Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (London, England : 1993). 13: 1643-51. PMID 16271887 DOI: 10.1016/j.str.2005.07.019  0.96
2005 Beeser A, Jaffer ZM, Hofmann C, Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. The Journal of Biological Chemistry. 280: 36609-15. PMID 16129686 DOI: 10.1074/jbc.M502306200  0.96
2005 Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV. Essential role of CIB1 in regulating PAK1 activation and cell migration. The Journal of Cell Biology. 170: 465-76. PMID 16061695 DOI: 10.1083/jcb.200502090  0.96
2005 Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 24: 2307-16. PMID 15735716 DOI: 10.1038/sj.onc.1208476  0.96
2004 Jaffer ZM, Chernoff J. The cross-Rho'ds of cell-cell adhesion. The Journal of Biological Chemistry. 279: 35123-6. PMID 15133033 DOI: 10.1074/jbc.R400010200  0.96
2003 Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Research. 63: 6802-8. PMID 14583477  0.96
2003 Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. The Embo Journal. 22: 4155-65. PMID 12912914 DOI: 10.1093/emboj/cdg398  0.96
2003 Cotteret S, Jaffer ZM, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Molecular and Cellular Biology. 23: 5526-39. PMID 12897128 DOI: 10.1128/MCB.23.16.5526-5539.2003  0.96
2003 Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 113: 507-17. PMID 12757711 DOI: 10.1016/S0092-8674(03)00355-6  0.96
2003 Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, Huganir RL. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron. 37: 263-74. PMID 12546821 DOI: 10.1016/S0896-6273(02)01168-6  0.96
2002 Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene. 21: 8470-6. PMID 12466966 DOI: 10.1038/sj.onc.1205962  0.96
2002 Nikolic M, Chernoff J. High midsummer for small GTPases. Trends in Cell Biology. 12: 495-7. PMID 12446103 DOI: 10.1016/S0962-8924(02)02365-6  0.96
2002 Serebriiskii IG, Mitina O, Pugacheva EN, Benevolenskaya E, Kotova E, Toby GG, Khazak V, Kaelin WG, Chernoff J, Golemis EA. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Research. 12: 1785-91. PMID 12421766 DOI: 10.1101/gr.450702  0.96
2002 Jaffer ZM, Chernoff J. p21-activated kinases: three more join the Pak. The International Journal of Biochemistry & Cell Biology. 34: 713-7. PMID 11950587 DOI: 10.1016/S1357-2725(01)00158-3  0.96
1992 Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Molecular and Cellular Biology. 12: 5571-80. PMID 1448087  0.96
1991 Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 88: 3455-9. PMID 1849659  0.96
1990 Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG. Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 2735-9. PMID 2157211  0.96
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