Marcelo G. Kazanietz - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Oncology, Cell Biology, Medicine and Surgery

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Casado-Medrano V, Barrio-Real L, Gutiérrez-Miranda L, González-Sarmiento R, Velasco EA, Kazanietz MG, Caloca MJ. Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1. The Journal of Biological Chemistry. PMID 31871052 DOI: 10.1074/jbc.RA119.008688  0.6
2019 Llorens MC, Rossi FA, García IA, Cooke M, Abba MC, Lopez-Haber C, Barrio-Real L, Vaglienti MV, Rossi M, Bocco JL, Kazanietz MG, Soria G. PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1. Frontiers in Oncology. 9: 1323. PMID 31828042 DOI: 10.3389/fonc.2019.01323  0.48
2019 Casado-Medrano V, Barrio-Real L, Wang A, Cooke M, Lopez-Haber C, Kazanietz MG. Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells. Oncogene. PMID 30923343 DOI: 10.1038/s41388-019-0796-4  0.48
2018 Casado-Medrano V, Baker MJ, Lopez-Haber C, Cooke M, Wang S, Caloca MJ, Kazanietz MG. The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic. Biochemical Society Transactions. PMID 30065108 DOI: 10.1042/BST20170519  0.6
2018 Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG. P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer. Oncotarget. 9: 28612-28624. PMID 29983884 DOI: 10.18632/oncotarget.25584  0.6
2018 Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene. PMID 29765153 DOI: 10.1038/s41388-018-0318-9  0.56
2018 Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes. The Journal of Biological Chemistry. PMID 29636415 DOI: 10.1074/jbc.RA117.000235  0.56
2018 Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, et al. Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy. Cell Death & Disease. 9: 23. PMID 29348560 DOI: 10.1038/s41419-017-0154-9  0.32
2017 Kazanietz MG, Caloca MJ. The Rac GTPase in cancer: from old concepts to new paradigms. Cancer Research. PMID 28807941 DOI: 10.1158/0008-5472.CAN-17-1456  0.6
2017 Garg R, Blando JM, Perez CJ, Abba MC, Benavides F, Kazanietz MG. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Reports. 19: 375-388. PMID 28402859 DOI: 10.1016/j.celrep.2017.03.042  0.56
2016 Kazanietz MG, Barrio-Real L, Casado-Medrano V, Baker MJ, Lopez-Haber C. The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses. Small Gtpases. 1-7. PMID 27588611 DOI: 10.1080/21541248.2016.1221273  0.48
2016 Barrio-Real L, Wertheimer E, Garg R, Abba MC, Kazanietz MG. Characterization of a P-Rex1 gene signature in breast cancer cells. Oncotarget. PMID 27351228 DOI: 10.18632/oncotarget.10285  0.56
2016 Lopez-Haber C, Barrio-Real L, Casado-Medrano V, Kazanietz MG. HEREGULIN/ErbB3 SIGNALING ENHANCES CXCR4-DRIVEN Rac1 ACTIVATION AND BREAST CANCER CELL MOTILITY VIA HIF-1α. Molecular and Cellular Biology. PMID 27185877 DOI: 10.1128/MCB.00180-16  0.48
2015 Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz MG. PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis. Molecular Cancer Research : McR. 13: 1336-46. PMID 26023164 DOI: 10.1158/1541-7786.MCR-15-0111  0.56
2015 Abera MB, Kazanietz MG. Protein kinase Cα mediates erlotinib resistance in lung cancer cells. Molecular Pharmacology. 87: 832-41. PMID 25724832 DOI: 10.1124/mol.115.097725  1
2014 Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG. Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation. Breast Cancer Research : Bcr. 16: 441. PMID 25248717 DOI: 10.1186/s13058-014-0441-7  0.56
2014 Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins. The Journal of Biological Chemistry. 289: 19823-38. PMID 24825907 DOI: 10.1074/jbc.M114.548446  1
2014 Zubeldia-Brenner L, Gutierrez-Uzquiza A, Barrio-Real L, Wang H, Kazanietz MG, Leskow FC. β3-chimaerin, a novel member of the chimaerin Rac-GAP family. Molecular Biology Reports. 41: 2067-76. PMID 24430297 DOI: 10.1007/s11033-014-3055-3  1
2014 Garg R, Benedetti LG, Abera MB, Wang H, Abba M, Kazanietz MG. Protein kinase C and cancer: what we know and what we do not. Oncogene. 33: 5225-37. PMID 24336328 DOI: 10.1038/onc.2013.524  0.56
2013 Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. Plos One. 8: e67319. PMID 23826267 DOI: 10.1371/journal.pone.0067319  0.56
2013 Dipaolo BC, Davidovich N, Kazanietz MG, Margulies SS. Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L141-53. PMID 23686855 DOI: 10.1152/ajplung.00298.2012  0.56
2013 Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG. Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nature Communications. 4: 1849. PMID 23673634 DOI: 10.1038/ncomms2834  0.56
2013 Lopez-Haber C, Kazanietz MG. Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1. Molecular Pharmacology. 83: 1141-54. PMID 23478800 DOI: 10.1124/mol.112.084293  0.32
2013 Millholland MG, Mishra S, Dupont CD, Love MS, Patel B, Shilling D, Kazanietz MG, Foskett JK, Hunter CA, Sinnis P, Greenbaum DC. A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host & Microbe. 13: 15-28. PMID 23332153 DOI: 10.1016/j.chom.2012.12.001  0.56
2012 Barrio-Real L, Kazanietz MG. Rho GEFs and cancer: linking gene expression and metastatic dissemination. Science Signaling. 5: pe43. PMID 23033535 DOI: 10.1126/scisignal.2003543  0.48
2012 Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG. Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon). The Journal of Biological Chemistry. 287: 37570-82. PMID 22955280 DOI: 10.1074/jbc.M112.398925  1
2012 Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 149: 1594-606. PMID 22726444 DOI: 10.1016/j.cell.2012.05.018  0.56
2012 Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. Plos One. 7: e31714. PMID 22384062 DOI: 10.1371/journal.pone.0031714  0.56
2012 Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C, Sosa MS, Kazanietz MG. Rac signaling in breast cancer: a tale of GEFs and GAPs. Cellular Signalling. 24: 353-62. PMID 21893191 DOI: 10.1016/j.cellsig.2011.08.011  0.48
2011 Wertheimer E, Kazanietz MG. Rac1 takes center stage in pancreatic cancer and ulcerative colitis: quantity matters. Gastroenterology. 141: 427-30. PMID 21704620 DOI: 10.1053/j.gastro.2011.06.027  0.56
2011 Wang H, Xiao L, Kazanietz MG. p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function. The Journal of Biological Chemistry. 286: 15821-31. PMID 21454541 DOI: 10.1074/jbc.M111.227991  1
2011 Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. The Journal of Biological Chemistry. 286: 11254-64. PMID 21252239 DOI: 10.1074/jbc.M110.194332  0.32
2011 Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, Kazanietz MG. Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions Cell Cycle. 10: 268-277. PMID 21224724 DOI: 10.4161/cc.10.2.14469  0.56
2010 Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular Cell. 40: 877-92. PMID 21172654 DOI: 10.1016/j.molcel.2010.11.029  0.56
2010 Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. The Journal of Biological Chemistry. 285: 26033-40. PMID 20566643 DOI: 10.1074/jbc.M110.128371  0.56
2010 von Burstin VA, Xiao L, Kazanietz MG. Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Molecular Pharmacology. 78: 325-32. PMID 20516369 DOI: 10.1124/mol.110.064741  0.64
2010 Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. The Journal of Biological Chemistry. 285: 16931-41. PMID 20335173 DOI: 10.1074/jbc.M109.099036  0.48
2010 Wang H, Kazanietz MG. p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. Molecular Biology of the Cell. 21: 1398-408. PMID 20164256 DOI: 10.1091/mbc.E09-08-0735  1
2010 Chinchilla P, Xiao L, Kazanietz MG, Riobo NA. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle (Georgetown, Tex.). 9: 570-79. PMID 20081366 DOI: 10.4161/cc.9.3.10591  0.56
2010 Mauro LV, Grossoni VC, Urtreger AJ, Yang C, Colombo LL, Morandi A, Pallotta MG, Kazanietz MG, Bal de Kier Joffé ED, Puricelli LL. PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas. 39: e31-41. PMID 19924022 DOI: 10.1097/MPA.0b013e3181bce796  0.56
2009 Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. The Journal of Biological Chemistry. 284: 29365-75. PMID 19667069 DOI: 10.1074/jbc.M109.007971  0.64
2009 Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis : An International Journal On Programmed Cell Death. 14: 392-408. PMID 19169823 DOI: 10.1007/s10495-009-0316-z  0.56
2009 Xiao L, Gonzalez-Guerrico A, Kazanietz MG. PKC-mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens. Molecular Carcinogenesis. 48: 187-95. PMID 18756441 DOI: 10.1002/mc.20476  0.64
2008 Colón-González F, Leskow FC, Kazanietz MG. Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin. The Journal of Biological Chemistry. 283: 35247-57. PMID 18826946 DOI: 10.1074/jbc.M806264200  0.48
2008 Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods in Enzymology. 446: 123-39. PMID 18603119 DOI: 10.1016/S0076-6879(08)01607-8  0.64
2008 Yang C, Klein EA, Assoian RK, Kazanietz MG. Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. The Biochemical Journal. 410: 167-75. PMID 17941827 DOI: 10.1042/BJ20070781  0.36
2007 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/jcs.03484  0.56
2007 Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS. Phospholipase cbeta is critical for T cell chemotaxis. Journal of Immunology (Baltimore, Md. : 1950). 179: 2223-7. PMID 17675482  0.56
2007 Klein EA, Yang C, Kazanietz MG, Assoian RK. NFkappaB-independent signaling to the cyclin D1 gene by Rac. Cell Cycle (Georgetown, Tex.). 6: 1115-21. PMID 17426454  0.36
2007 Yang C, Kazanietz MG. Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac. The Biochemical Journal. 403: 1-12. PMID 17346241 DOI: 10.1042/BJ20061750  0.36
2006 Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Research. 66: 11792-801. PMID 17178875 DOI: 10.1158/0008-5472.CAN-06-1139  0.36
2006 Wang H, Kazanietz MG. The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. Biochemical Society Transactions. 34: 855-7. PMID 17052214 DOI: 10.1042/BST0340855  1
2006 Colón-González F, Kazanietz MG. C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochimica Et Biophysica Acta. 1761: 827-37. PMID 16861033 DOI: 10.1016/j.bbalip.2006.05.001  0.48
2006 Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. The Embo Journal. 25: 2062-74. PMID 16628218 DOI: 10.1038/sj.emboj.7601098  1
2006 Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proceedings of the National Academy of Sciences of the United States of America. 103: 5373-8. PMID 16569702 DOI: 10.1073/pnas.0508585103  0.56
2006 Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Molecular and Cellular Biology. 26: 831-42. PMID 16428439 DOI: 10.1128/MCB.26.3.831-842.2006  0.36
2006 Siliceo M, García-Bernal D, Carrasco S, Díaz-Flores E, Coluccio Leskow F, Leskow FC, Teixidó J, Kazanietz MG, Mérida I. Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. Journal of Cell Science. 119: 141-52. PMID 16352660 DOI: 10.1242/jcs.02722  0.48
2005 Gonzalez-Guerrico AM, Meshki J, Xiao L, Benavides F, Conti CJ, Kazanietz MG. Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. Journal of Biochemistry and Molecular Biology. 38: 639-45. PMID 16336777  0.56
2005 Santiago-Walker AE, Fikaris AJ, Kao GD, Brown EJ, Kazanietz MG, Meinkoth JL. Protein kinase C δ stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest Journal of Biological Chemistry. 280: 32107-32114. PMID 16051606 DOI: 10.1074/jbc.M504432200  0.56
2005 Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. The Journal of Biological Chemistry. 280: 24363-70. PMID 15863513 DOI: 10.1074/jbc.M411629200  0.56
2004 Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH. Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell. 119: 407-18. PMID 15507211 DOI: 10.1016/j.cell.2004.10.012  0.48
2004 Frey MR, Clark JA, Bateman NW, Kazanietz MG, Black AR, Black JD. Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells. Biochemical Pharmacology. 67: 1873-86. PMID 15130764 DOI: 10.1016/j.bcp.2004.02.006  0.56
2003 Yang C, Kazanietz MG. Divergence and complexities in DAG signaling: looking beyond PKC. Trends in Pharmacological Sciences. 24: 602-8. PMID 14607084 DOI: 10.1016/  0.36
2003 Caloca MJ, Wang H, Kazanietz MG. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. The Biochemical Journal. 375: 313-21. PMID 12877655 DOI: 10.1042/BJ20030727  1
2003 Menna PL, Skilton G, Leskow FC, Alonso DF, Gomez DE, Kazanietz MG. Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Research. 63: 2284-91. PMID 12727851  0.48
2002 Roaten JB, Kazanietz MG, Caloca MJ, Bertics PJ, Lothstein L, Parrill AL, Israel M, Sweatman TW. Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Molecular Cancer Therapeutics. 1: 483-92. PMID 12479266  0.56
2002 Yu D, Kazanietz MG, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C. Biochemistry. 41: 11888-94. PMID 12269833 DOI: 10.1021/bi020270p  0.56
2002 Wang H, Kazanietz MG. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. The Journal of Biological Chemistry. 277: 4541-50. PMID 11689559 DOI: 10.1074/jbc.M107150200  1
2002 Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. The Journal of Biological Chemistry. 277: 645-55. PMID 11584014 DOI: 10.1074/jbc.M107639200  0.48
2001 Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. The Journal of Biological Chemistry. 276: 18303-12. PMID 11278894 DOI: 10.1074/jbc.M011368200  1
2000 Kazanietz MG, Caloca MJ, Eroles P, Fujii T, García-Bermejo ML, Reilly M, Wang H. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochemical Pharmacology. 60: 1417-24. PMID 11020443  1
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