| Year |
Citation |
Score |
| 2024 |
Boyer JL, Schachter JB, Sromek SM, Palmer RK, Jacobson KA, Nicholas RA, Harden TK. Avian and Human Homologues of the P2Y Receptor: Pharmacological, Signaling, and Molecular Properties. Drug Development Research. 39: 253-261. PMID 38235168 DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<253::aid-ddr4>3.0.co;2-q |
0.612 |
|
| 2017 |
Huang W, Wang X, Endo-Streeter S, Barrett M, Waybright J, Wohlfeld C, Hajicek N, Harden TK, Sondek J, Zhang Q. A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes. The Journal of Biological Chemistry. PMID 29263090 DOI: 10.1074/Jbc.Ra117.000926 |
0.46 |
|
| 2016 |
Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J. Potent and Selective Peptide-based Inhibition of the G protein Gαq. The Journal of Biological Chemistry. PMID 27742837 DOI: 10.1074/Jbc.M116.740407 |
0.356 |
|
| 2016 |
Sesma JI, Weitzer CD, Livraghi-Butrico A, Dang H, Donaldson S, Alexis NE, Jacobson KA, Harden TK, Lazarowski ER. UDP-glucose promotes neutrophil recruitment in the lung. Purinergic Signalling. PMID 27421735 DOI: 10.1007/S11302-016-9524-5 |
0.436 |
|
| 2016 |
Junker A, Balasubramanian R, Ciancetta A, Uliassi E, Kiselev E, Martiriggiano C, Trujillo K, Mtchedlidze G, Birdwell L, Brown KA, Harden TK, Jacobson KA. Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists. Journal of Medicinal Chemistry. PMID 27331270 DOI: 10.1021/Acs.Jmedchem.6B00044 |
0.553 |
|
| 2015 |
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, ... ... Harden TK, et al. The experimental power of FR900359 to study Gq-regulated biological processes. Nature Communications. 6: 10156. PMID 26658454 DOI: 10.1038/Ncomms10156 |
0.38 |
|
| 2015 |
Kiselev E, Balasubramanian R, Uliassi E, Brown KA, Trujillo K, Katritch V, Hammes E, Stevens RC, Harden TK, Jacobson KA. Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor. Bioorganic & Medicinal Chemistry Letters. 25: 4733-9. PMID 26303895 DOI: 10.1016/J.Bmcl.2015.08.021 |
0.591 |
|
| 2015 |
Lazarowski ER, Harden TK. UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation. Molecular Pharmacology. 88: 151-60. PMID 25829059 DOI: 10.1124/Mol.115.098756 |
0.514 |
|
| 2014 |
Kiselev E, Barrett MO, Katritch V, Paoletta S, Weitzer CD, Brown KA, Hammes E, Yin AL, Zhao Q, Stevens RC, Harden TK, Jacobson KA. Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes. Acs Chemical Biology. 9: 2833-42. PMID 25299434 DOI: 10.1021/Cb500614P |
0.61 |
|
| 2014 |
Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, ... ... Harden TK, et al. A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation. Chemistry & Biology. 21: 890-902. PMID 25036778 DOI: 10.1016/J.Chembiol.2014.06.003 |
0.382 |
|
| 2014 |
Song L, Risseeuw MD, Karalic I, Barrett MO, Brown KA, Harden TK, Van Calenbergh S. Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand. Molecules (Basel, Switzerland). 19: 4313-25. PMID 24714193 DOI: 10.3390/Molecules19044313 |
0.476 |
|
| 2014 |
Jayasekara PS, Barrett MO, Ball CB, Brown KA, Hammes E, Balasubramanian R, Harden TK, Jacobson KA. 4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors. Journal of Medicinal Chemistry. 57: 3874-83. PMID 24712832 DOI: 10.1021/Jm500367E |
0.604 |
|
| 2013 |
Harden TK. Enigmatic GPCR finds a stimulating drug. Science Signaling. 6: pe34. PMID 24150253 DOI: 10.1126/Scisignal.2004755 |
0.482 |
|
| 2013 |
Qi AD, Harden TK, Nicholas RA. Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. The Journal of Pharmacology and Experimental Therapeutics. 347: 38-46. PMID 23908386 DOI: 10.1124/Jpet.113.207647 |
0.575 |
|
| 2013 |
Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. Biochemistry. 52: 4810-9. PMID 23777354 DOI: 10.1021/Bi400433B |
0.308 |
|
| 2013 |
Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Molecular Pharmacology. 84: 41-9. PMID 23592514 DOI: 10.1124/Mol.113.085654 |
0.623 |
|
| 2013 |
Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q. Small molecule inhibitors of phospholipase C from a novel high-throughput screen. The Journal of Biological Chemistry. 288: 5840-8. PMID 23297405 DOI: 10.1074/Jbc.M112.422501 |
0.363 |
|
| 2012 |
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, et al. G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Science Signaling. 5: ra89. PMID 23211529 DOI: 10.1126/Scisignal.2003264 |
0.465 |
|
| 2012 |
Wang X, Barrett M, Sondek J, Harden TK, Zhang Q. Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. Biochemistry. 51: 5300-6. PMID 22703043 DOI: 10.1021/Bi300637H |
0.318 |
|
| 2012 |
Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. American Journal of Physiology. Cell Physiology. 303: C490-8. PMID 22673622 DOI: 10.1152/Ajpcell.00138.2012 |
0.42 |
|
| 2012 |
Gresset A, Sondek J, Harden TK. The phospholipase C isozymes and their regulation. Sub-Cellular Biochemistry. 58: 61-94. PMID 22403074 DOI: 10.1007/978-94-007-3012-0_3 |
0.49 |
|
| 2011 |
Harden TK, Waldo GL, Hicks SN, Sondek J. Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. Chemical Reviews. 111: 6120-9. PMID 21988240 DOI: 10.1021/Cr200209P |
0.444 |
|
| 2011 |
Friedman EJ, Wang HX, Jiang K, Perovic I, Deshpande A, Pochapsky TC, Temple BR, Hicks SN, Harden TK, Jones AM. Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis. The Journal of Biological Chemistry. 286: 30107-18. PMID 21712381 DOI: 10.1074/Jbc.M111.227256 |
0.329 |
|
| 2011 |
von Kügelgen I, Harden TK. Molecular pharmacology, physiology, and structure of the P2Y receptors. Advances in Pharmacology (San Diego, Calif.). 61: 373-415. PMID 21586365 DOI: 10.1016/B978-0-12-385526-8.00012-6 |
0.584 |
|
| 2011 |
Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA. Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor. Journal of Medicinal Chemistry. 54: 4018-33. PMID 21528910 DOI: 10.1021/Jm101591J |
0.658 |
|
| 2011 |
Qi AD, Houston-Cohen D, Naruszewicz I, Harden TK, Nicholas RA. Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells. British Journal of Pharmacology. 162: 1304-13. PMID 21108629 DOI: 10.1111/J.1476-5381.2010.01135.X |
0.562 |
|
| 2011 |
Poecke SV, Barrett M, Jacobson KA, Harden TK, Calenbergh SV. Synthesis of base-substituted uridine 5'-phosphonate analogues as potential P2Y2 receptor ligands Collection of Czechoslovak Chemical Communications. 12: 485-486. DOI: 10.1135/Css201112485 |
0.636 |
|
| 2010 |
Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK. Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (New York, N.Y.). 330: 974-80. PMID 20966218 DOI: 10.1126/Science.1193438 |
0.373 |
|
| 2010 |
Gresset A, Hicks SN, Harden TK, Sondek J. Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. The Journal of Biological Chemistry. 285: 35836-47. PMID 20807769 DOI: 10.1074/Jbc.M110.166512 |
0.327 |
|
| 2010 |
Ohlmann P, de Castro S, Brown GG, Gachet C, Jacobson KA, Harden TK. Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500). Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 62: 344-51. PMID 20594939 DOI: 10.1016/J.Phrs.2010.05.007 |
0.615 |
|
| 2010 |
Wolff SC, Qi AD, Harden TK, Nicholas RA. Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal. Journal of Cell Science. 123: 2512-20. PMID 20592187 DOI: 10.1242/Jcs.060723 |
0.387 |
|
| 2010 |
de Castro S, Maruoka H, Hong K, Kilbey SM, Costanzi S, Hechler B, Brown GG, Gachet C, Harden TK, Jacobson KA. Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. Bioconjugate Chemistry. 21: 1190-205. PMID 20565071 DOI: 10.1021/Bc900569U |
0.638 |
|
| 2010 |
Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. Journal of Medicinal Chemistry. 53: 4488-501. PMID 20446735 DOI: 10.1021/Jm100287T |
0.666 |
|
| 2010 |
Harden TK, Sesma JI, Fricks IP, Lazarowski ER. Signalling and pharmacological properties of the P2Y receptor. Acta Physiologica (Oxford, England). 199: 149-60. PMID 20345417 DOI: 10.1111/j.1748-1716.2010.02116.x |
0.488 |
|
| 2010 |
Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA. Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide. Bioconjugate Chemistry. 21: 372-84. PMID 20121074 DOI: 10.1021/Bc900473V |
0.626 |
|
| 2010 |
Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. Journal of Medicinal Chemistry. 53: 471-80. PMID 19902968 DOI: 10.1021/Jm901432G |
0.604 |
|
| 2009 |
Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Molecular Pharmacology. 76: 1341-8. PMID 19759354 DOI: 10.1124/Mol.109.058578 |
0.674 |
|
| 2009 |
Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 461: 282-6. PMID 19741708 DOI: 10.1038/Nature08296 |
0.35 |
|
| 2009 |
Das A, Zhou Y, Ivanov AA, Carter RL, Harden TK, Jacobson KA. Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition. Bioconjugate Chemistry. 20: 1650-9. PMID 19572637 DOI: 10.1021/Bc900206G |
0.654 |
|
| 2009 |
Ko H, Das A, Carter RL, Fricks IP, Zhou Y, Ivanov AA, Melman A, Joshi BV, Kovác P, Hajduch J, Kirk KL, Harden TK, Jacobson KA. Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. Bioorganic & Medicinal Chemistry. 17: 5298-311. PMID 19502066 DOI: 10.1016/J.Bmc.2009.05.024 |
0.615 |
|
| 2009 |
Fricks IP, Carter RL, Lazarowski ER, Harden TK. Gi-dependent cell signaling responses of the human P2Y 14 receptor in model cell systems Journal of Pharmacology and Experimental Therapeutics. 330: 162-168. PMID 19339661 DOI: 10.1124/Jpet.109.150730 |
0.457 |
|
| 2009 |
Cha JY, Maddileti S, Mitin N, Harden TK, Der CJ. Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. The Journal of Biological Chemistry. 284: 6227-40. PMID 19103595 DOI: 10.1074/Jbc.M803998200 |
0.43 |
|
| 2009 |
Harden TK, Hicks SN, Sondek J. Phospholipase C isozymes as effectors of Ras superfamily GTPases. Journal of Lipid Research. 50: S243-8. PMID 19033212 DOI: 10.1194/Jlr.R800045-Jlr200 |
0.384 |
|
| 2009 |
Jacobson KA, Ivanov AA, de Castro S, Harden TK, Ko H. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signalling. 5: 75-89. PMID 18600475 DOI: 10.1007/S11302-008-9106-2 |
0.652 |
|
| 2009 |
Costanzi S, Tikhonova IG, Harden TK, Jacobson KA. Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands. Journal of Computer-Aided Molecular Design. 23: 747-54. PMID 18483766 DOI: 10.1007/S10822-008-9218-3 |
0.533 |
|
| 2008 |
Seifert JP, Zhou Y, Hicks SN, Sondek J, Harden TK. Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. The Journal of Biological Chemistry. 283: 29690-8. PMID 18765661 DOI: 10.1074/Jbc.M805038200 |
0.326 |
|
| 2008 |
Hicks SN, Jezyk MR, Gershburg S, Seifert JP, Harden TK, Sondek J. General and versatile autoinhibition of PLC isozymes. Molecular Cell. 31: 383-94. PMID 18691970 DOI: 10.1016/J.Molcel.2008.06.018 |
0.386 |
|
| 2008 |
Houston D, Costanzi S, Jacobson KA, Harden TK. Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor. Combinatorial Chemistry & High Throughput Screening. 11: 410-9. PMID 18673269 DOI: 10.2174/138620708784911474 |
0.655 |
|
| 2008 |
Ko H, Carter RL, Cosyn L, Petrelli R, de Castro S, Besada P, Zhou Y, Cappellacci L, Franchetti P, Grifantini M, Van Calenbergh S, Harden TK, Jacobson KA. Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorganic & Medicinal Chemistry. 16: 6319-32. PMID 18514530 DOI: 10.1016/J.Bmc.2008.05.013 |
0.658 |
|
| 2008 |
Zhou Y, Sondek J, Harden TK. Activation of human phospholipase C-eta2 by Gbetagamma. Biochemistry. 47: 4410-7. PMID 18361507 DOI: 10.1021/Bi800044N |
0.386 |
|
| 2008 |
Fricks IP, Maddileti S, Carter RL, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. UDP is a competitive antagonist at the human P2Y14 receptor. The Journal of Pharmacology and Experimental Therapeutics. 325: 588-94. PMID 18252808 DOI: 10.1124/Jpet.108.136309 |
0.577 |
|
| 2008 |
Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J. Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nature Structural & Molecular Biology. 15: 155-62. PMID 18204463 DOI: 10.1038/Nsmb.1377 |
0.355 |
|
| 2008 |
Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Molecular Carcinogenesis. 47: 326-37. PMID 17932950 DOI: 10.1002/Mc.20389 |
0.315 |
|
| 2007 |
Costanzi S, Tikhonova IG, Ohno M, Roh EJ, Joshi BV, Colson AO, Houston D, Maddileti S, Harden TK, Jacobson KA. P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. Journal of Medicinal Chemistry. 50: 3229-41. PMID 17564423 DOI: 10.1021/Jm0700971 |
0.548 |
|
| 2007 |
Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. Journal of Medicinal Chemistry. 50: 2030-9. PMID 17407275 DOI: 10.1021/Jm061222W |
0.648 |
|
| 2007 |
Ivanov AA, Ko H, Cosyn L, Maddileti S, Besada P, Fricks I, Costanzi S, Harden TK, Calenbergh SV, Jacobson KA. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. Journal of Medicinal Chemistry. 50: 1166-76. PMID 17302398 DOI: 10.1021/Jm060903O |
0.624 |
|
| 2007 |
Fricks IP, Maddileti S, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK. UDP is an antagonist at the hP2Y14 receptor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A424-C |
0.626 |
|
| 2006 |
Jezyk MR, Snyder JT, Gershberg S, Worthylake DK, Harden TK, Sondek J. Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nature Structural & Molecular Biology. 13: 1135-40. PMID 17115053 DOI: 10.1038/Nsmb1175 |
0.316 |
|
| 2006 |
Besada P, Shin DH, Costanzi S, Ko H, Mathé C, Gagneron J, Gosselin G, Maddileti S, Harden TK, Jacobson KA. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. Journal of Medicinal Chemistry. 49: 5532-43. PMID 16942026 DOI: 10.1021/Jm060485N |
0.625 |
|
| 2006 |
Bourdon DM, Mahanty SK, Jacobson KA, Boyer JL, Harden TK. (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. Journal of Thrombosis and Haemostasis : Jth. 4: 861-8. PMID 16634757 DOI: 10.1111/J.1538-7836.2006.01866.X |
0.595 |
|
| 2006 |
Hains MD, Wing MR, Maddileti S, Siderovski DP, Harden TK. Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. Molecular Pharmacology. 69: 2068-75. PMID 16554409 DOI: 10.1124/Mol.105.017921 |
0.569 |
|
| 2006 |
Bourdon DM, Wing MR, Edwards EB, Sondek J, Harden TK. Quantification of isozyme-specific activation of phospholipase C-β2 by Rac GTPases and phospholipase C-ε by Rho GTPases in an intact cell assay system Methods in Enzymology. 406: 489-499. PMID 16472681 DOI: 10.1016/S0076-6879(06)06037-X |
0.437 |
|
| 2006 |
Snyder JT, Jezyk MR, Gershburg S, Harden TK, Sondek J. Regulation of PLCbeta isoforms by Rac. Methods in Enzymology. 406: 272-80. PMID 16472664 DOI: 10.1016/S0076-6879(06)06020-4 |
0.325 |
|
| 2006 |
Seifert JP, Snyder JT, Sondek J, Harden TK. Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles. Methods in Enzymology. 406: 260-71. PMID 16472663 DOI: 10.1016/S0076-6879(06)06019-8 |
0.353 |
|
| 2006 |
Harden TK, Sondek J. Regulation of phospholipase C isozymes by ras superfamily GTPases. Annual Review of Pharmacology and Toxicology. 46: 355-79. PMID 16402909 DOI: 10.1146/Annurev.Pharmtox.46.120604.141223 |
0.416 |
|
| 2006 |
Jacobson KA, Costanzi S, Ivanov AA, Tchilibon S, Besada P, Gao ZG, Maddileti S, Harden TK. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochemical Pharmacology. 71: 540-9. PMID 16359641 DOI: 10.1016/J.Bcp.2005.11.010 |
0.662 |
|
| 2006 |
Houston D, Ohno M, Nicholas RA, Jacobson KA, Harden TK. [32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors. British Journal of Pharmacology. 147: 459-67. PMID 16299552 DOI: 10.1038/Sj.Bjp.0706453 |
0.625 |
|
| 2005 |
Costanzi S, Joshi BV, Maddileti S, Mamedova L, Gonzalez-Moa MJ, Marquez VE, Harden TK, Jacobson KA. Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference. Journal of Medicinal Chemistry. 48: 8108-11. PMID 16366591 DOI: 10.1021/Jm050911P |
0.604 |
|
| 2005 |
Zhou Y, Wing MR, Sondek J, Harden TK. Molecular cloning and characterization of PLC-η2 Biochemical Journal. 391: 667-676. PMID 16107206 DOI: 10.1042/Bj20050839 |
0.349 |
|
| 2005 |
Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (London, England : 1993). 13: 1069-80. PMID 16004878 DOI: 10.1016/J.Str.2005.04.007 |
0.332 |
|
| 2005 |
Wolff SC, Qi AD, Harden TK, Nicholas RA. Polarized expression of human P2Y receptors in epithelial cells from kidney, lung, and colon. American Journal of Physiology. Cell Physiology. 288: C624-32. PMID 15525684 DOI: 10.1152/Ajpcell.00338.2004 |
0.507 |
|
| 2005 |
Alvarado-Castillo C, Harden TK, Boyer JL. Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2 Molecular Pharmacology. 67: 114-122. PMID 15496502 DOI: 10.1124/Mol.104.006908 |
0.58 |
|
| 2004 |
Qi AD, Harden TK, Nicholas RA. GPR80/99, proposed to be the P2Y(15) receptor activated by adenosine and AMP, is not a P2Y receptor. Purinergic Signalling. 1: 67-74. PMID 18404402 DOI: 10.1007/S11302-004-5069-0 |
0.529 |
|
| 2004 |
Bodor ET, Waldo GL, Blaesius R, Harden TK. Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins. Purinergic Signalling. 1: 43-9. PMID 18404399 DOI: 10.1007/S11302-004-4748-1 |
0.57 |
|
| 2004 |
Hooks SB, Harden TK. Purification and in vitro functional analysis of R7 subfamily RGS proteins in complex with Gbeta5. Methods in Enzymology. 390: 163-77. PMID 15488177 DOI: 10.1016/S0076-6879(04)90011-0 |
0.358 |
|
| 2004 |
Cattaneo M, Lecchi A, Ohno M, Joshi BV, Besada P, Tchilibon S, Lombardi R, Bischofberger N, Harden TK, Jacobson KA. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochemical Pharmacology. 68: 1995-2002. PMID 15476670 DOI: 10.1016/J.Bcp.2004.06.026 |
0.623 |
|
| 2004 |
Ohno M, Costanzi S, Kim HS, Kempeneers V, Vastmans K, Herdewijn P, Maddileti S, Gao ZG, Harden TK, Jacobson KA. Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors. Bioorganic & Medicinal Chemistry. 12: 5619-30. PMID 15465340 DOI: 10.1016/J.Bmc.2004.07.067 |
0.59 |
|
| 2004 |
Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. The Journal of Pharmacology and Experimental Therapeutics. 311: 1038-43. PMID 15345752 DOI: 10.1124/Jpet.104.068650 |
0.676 |
|
| 2004 |
Seifert JP, Wing MR, Snyder JT, Gershburg S, Sondek J, Harden TK. RhoA activates purified phospholipase C-ε by a guanine nucleotide-dependent mechanism Journal of Biological Chemistry. 279: 47992-47997. PMID 15322077 DOI: 10.1074/Jbc.M407111200 |
0.384 |
|
| 2004 |
Hains MD, Siderovski DP, Harden TK. Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. Methods in Enzymology. 389: 71-88. PMID 15313560 DOI: 10.1016/S0076-6879(04)89005-0 |
0.481 |
|
| 2004 |
Wu YL, Hooks SB, Harden TK, Dohlman HG. Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit. The Journal of Biological Chemistry. 279: 35287-97. PMID 15197187 DOI: 10.1074/Jbc.M404896200 |
0.467 |
|
| 2004 |
Kim MG, Bodor ET, Harden TK, Kohn H. C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands. Bioorganic & Medicinal Chemistry. 12: 2357-67. PMID 15080933 DOI: 10.1016/J.Bmc.2004.02.016 |
0.537 |
|
| 2004 |
Waldo GL, Harden TK. Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor. Molecular Pharmacology. 65: 426-36. PMID 14742685 DOI: 10.1124/Mol.65.2.426 |
0.479 |
|
| 2004 |
Herold CL, Qi AD, Harden TK, Nicholas RA. Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop. The Journal of Biological Chemistry. 279: 11456-64. PMID 14670966 DOI: 10.1074/Jbc.M301734200 |
0.575 |
|
| 2003 |
Wing MR, Bourdon DM, Harden TK. PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling Mol Interv. 3: 273-280. PMID 14993441 DOI: 10.1124/Mi.3.5.273 |
0.391 |
|
| 2003 |
Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA. 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. Journal of Medicinal Chemistry. 46: 4974-87. PMID 14584948 DOI: 10.1021/Jm030127+ |
0.618 |
|
| 2003 |
Bodor ET, Waldo GL, Hooks SB, Corbitt J, Boyer JL, Harden TK. Purification and functional reconstitution of the human P2Y12 receptor. Molecular Pharmacology. 64: 1210-6. PMID 14573771 DOI: 10.1124/Mol.64.5.1210 |
0.434 |
|
| 2003 |
Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Molecular Pharmacology. 64: 785-95. PMID 14500734 DOI: 10.1124/Mol.64.4.785 |
0.49 |
|
| 2003 |
Wing MR, Snyder JT, Sondek J, Harden TK. Direct Activation of Phospholipase C-ε by Rho Journal of Biological Chemistry. 278: 41253-41258. PMID 12900402 DOI: 10.1074/Jbc.M306904200 |
0.315 |
|
| 2003 |
Mateo J, Kreda S, Henry CE, Harden TK, Boyer JL. Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme. The Journal of Biological Chemistry. 278: 39960-8. PMID 12888562 DOI: 10.1074/Jbc.M307854200 |
0.346 |
|
| 2003 |
Kim MG, Bodor ET, Wang C, Harden TK, Kohn H. C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. Journal of Medicinal Chemistry. 46: 2216-26. PMID 12747793 DOI: 10.1021/Jm020572P |
0.437 |
|
| 2003 |
Lazarowski ER, Shea DA, Boucher RC, Harden TK. Release of cellular UDP-glucose as a potential extracellular signaling molecule. Molecular Pharmacology. 63: 1190-7. PMID 12695547 DOI: 10.1124/Mol.63.5.1190 |
0.328 |
|
| 2003 |
Hooks SB, Waldo GL, Corbitt J, Bodor ET, Krumins AM, Harden TK. RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity. The Journal of Biological Chemistry. 278: 10087-93. PMID 12531899 DOI: 10.1074/Jbc.M211382200 |
0.396 |
|
| 2002 |
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, ... ... Harden TK, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/Nature01304 |
0.504 |
|
| 2002 |
Waldo GL, Corbitt J, Boyer JL, Ravi G, Kim HS, Ji XD, Lacy J, Jacobson KA, Harden TK. Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Molecular Pharmacology. 62: 1249-57. PMID 12391289 DOI: 10.1124/Mol.62.5.1249 |
0.537 |
|
| 2002 |
Alvarado-Castillo C, Lozano-Zarain P, Mateo J, Harden TK, Boyer JL. A fusion protein of the human P2Y1 receptor and NTPDase1 exhibits functional activities of the native receptor and ectoenzyme and reduced signaling responses to endogenously released nucleotides Molecular Pharmacology. 62: 521-528. PMID 12181428 DOI: 10.1124/Mol.62.3.521 |
0.542 |
|
| 2002 |
Ravi RG, Kim HS, Servos J, Zimmermann H, Lee K, Maddileti S, Boyer JL, Harden TK, Jacobson KA. Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. Journal of Medicinal Chemistry. 45: 2090-100. PMID 11985476 DOI: 10.1021/Jm010538V |
0.646 |
|
| 2002 |
Boyer JL, Adams M, Ghana Ravi R, Jacobson KA, Harden TK. 2-chloro N 6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′, 5′-bisphosphate is a selective high affinity P2Y 1 receptor antagonist British Journal of Pharmacology. 135: 2004-2010. PMID 11959804 DOI: 10.1038/Sj.Bjp.0704673 |
0.649 |
|
| 2002 |
Hou M, Harden TK, Kuhn CM, Baldetorp B, Lazarowski E, Pendergast W, Möller S, Edvinsson L, Erlinge D. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. American Journal of Physiology. Heart and Circulatory Physiology. 282: H784-92. PMID 11788430 DOI: 10.1152/Ajpheart.00997.2000 |
0.548 |
|
| 2002 |
Kim HS, Ravi RG, Marquez VE, Maddileti S, Wihlborg AK, Erlinge D, Malmsjö M, Boyer JL, Harden TK, Jacobson KA. Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. Journal of Medicinal Chemistry. 45: 208-18. PMID 11754592 DOI: 10.1021/Jm010369E |
0.605 |
|
| 2002 |
Singer AU, Waldo GL, Harden TK, Sondek J. A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nature Structural Biology. 9: 32-6. PMID 11753430 DOI: 10.1038/Nsb731 |
0.319 |
|
| 2001 |
Harden TK, Boyer JL, Dougherty RW. Drug analysis based on signaling responses to g-protein-coupled receptors Journal of Receptor and Signal Transduction Research. 21: 167-190. PMID 11757682 DOI: 10.1081/Rrs-100107427 |
0.412 |
|
| 2001 |
Wing MR, Houston D, Kelley GG, Der CJ, Siderovski DP, Harden TK. Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits Journal of Biological Chemistry. 276: 48257-48261. PMID 11641393 DOI: 10.1074/Jbc.C100574200 |
0.386 |
|
| 2001 |
Kim HS, Barak D, Harden TK, Boyer JL, Jacobson KA. Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. Journal of Medicinal Chemistry. 44: 3092-108. PMID 11543678 DOI: 10.1021/Jm010082H |
0.617 |
|
| 2001 |
Kim YC, Brown SG, Harden TK, Boyer JL, Dubyak G, King BF, Burnstock G, Jacobson KA. Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. Journal of Medicinal Chemistry. 44: 340-9. PMID 11462975 DOI: 10.1021/jm9904203 |
0.603 |
|
| 2001 |
Jacobson KA, Moro S, Hoffmann C, Kim YC, Kim HS, Ravi RG, Harden TK, Boyer JL. Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. Farmaco (Società Chimica Italiana : 1989). 56: 71-5. PMID 11347970 DOI: 10.1016/S0014-827X(01)01023-0 |
0.631 |
|
| 2001 |
Lazarowski ER, Rochelle LG, O'Neal WK, Ribeiro CM, Grubb BR, Zhang V, Harden TK, Boucher RC. Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. The Journal of Pharmacology and Experimental Therapeutics. 297: 43-9. PMID 11259526 |
0.422 |
|
| 2001 |
Qi AD, Kennedy C, Harden TK, Nicholas RA. Differential coupling of the human P2Y 11 receptor to phospholipase C and adenylyl cyclase British Journal of Pharmacology. 132: 318-326. PMID 11156592 DOI: 10.1038/Sj.Bjp.0703788 |
0.446 |
|
| 2001 |
Brinson AE, Harden TK. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. The Journal of Biological Chemistry. 276: 11939-48. PMID 11114308 DOI: 10.1074/Jbc.M009909200 |
0.433 |
|
| 2001 |
Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. The Journal of Biological Chemistry. 276: 5438-44. PMID 11063746 DOI: 10.1074/Jbc.M007699200 |
0.765 |
|
| 2001 |
Lazarowski ER, Boucher RC, Harden TK. Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors Drug Development Research. 53: 66-71. DOI: 10.1002/Ddr.1172 |
0.464 |
|
| 2000 |
Mutafova-Yambolieva VN, Carolan BM, Harden TK, Keef KD. Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein General Pharmacology. 34: 127-136. PMID 10974420 DOI: 10.1016/S0306-3623(00)00054-9 |
0.438 |
|
| 2000 |
Malmsjö M, Adner M, Harden TK, Pendergast W, Edvinsson L, Erlinge D. The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. British Journal of Pharmacology. 131: 51-6. PMID 10960068 DOI: 10.1038/Sj.Bjp.0703536 |
0.55 |
|
| 2000 |
Lazarowski ER, Boucher RC, Harden TK. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. The Journal of Biological Chemistry. 275: 31061-8. PMID 10913128 DOI: 10.1074/Jbc.M003255200 |
0.344 |
|
| 2000 |
Malmsjö M, Hou M, Harden TK, Pendergast W, Pantev E, Edvinsson L, Erlinge D. Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate. The Journal of Pharmacology and Experimental Therapeutics. 293: 755-60. PMID 10869373 |
0.406 |
|
| 2000 |
Kennedy C, Qi AD, Herold CL, Harden TK, Nicholas RA. ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Molecular Pharmacology. 57: 926-31. PMID 10779375 |
0.464 |
|
| 2000 |
Boyer JL, Delaney SM, Villanueva D, Harden TK. A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates Molecular Pharmacology. 57: 805-810. PMID 10727529 DOI: 10.1124/Mol.57.4.805 |
0.61 |
|
| 2000 |
Nandanan E, Jang SY, Moro S, Kim HO, Siddiqui MA, Russ P, Marquez VE, Busson R, Herdewijn P, Harden TK, Boyer JL, Jacobson KA. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. Journal of Medicinal Chemistry. 43: 829-42. PMID 10715151 DOI: 10.1021/Jm990249V |
0.546 |
|
| 2000 |
Kim YC, Gallo-Rodriguez C, Jang SY, Nandanan E, Adams M, Harden TK, Boyer JL, Jacobson KA. Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. Journal of Medicinal Chemistry. 43: 746-55. PMID 10691699 DOI: 10.1021/jm9905211 |
0.603 |
|
| 1999 |
Jacobson KA, Hoffmann C, Kim YC, Camaioni E, Nandanan E, Jang SY, Guo DP, Ji XD, von Kügelgen I, Moro S, Ziganshin AU, Rychkov A, King BF, Brown SG, Wildman SS, ... ... Harden TK, et al. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Progress in Brain Research. 120: 119-32. PMID 10550992 DOI: 10.1016/S0079-6123(08)63550-5 |
0.56 |
|
| 1999 |
Mateo J, Harden TK, Boyer JL. Functional expression of a cDNA encoding a human ecto-ATPase British Journal of Pharmacology. 128: 396-402. PMID 10510450 DOI: 10.1038/Sj.Bjp.0702805 |
0.346 |
|
| 1999 |
Lazarowski ER, Harden TK. Quantitation of extracellular UTP using a sensitive enzymatic assay. British Journal of Pharmacology. 127: 1272-8. PMID 10455275 DOI: 10.1038/Sj.Bjp.0702654 |
0.388 |
|
| 1999 |
Cunningham ML, Filtz TM, Harden TK. Protein kinase C-promoted inhibition of Gα11-stimulated phospholipase C-β activity Molecular Pharmacology. 56: 265-271. PMID 10419544 DOI: 10.1124/Mol.56.2.265 |
0.402 |
|
| 1999 |
Myung CS, Paterson A, Harden TK, Garrison JC. Development of an assay for phospholipase C using column-reconstituted, extruded phospholipid vesicles. Analytical Biochemistry. 270: 303-13. PMID 10334848 DOI: 10.1006/Abio.1999.4086 |
0.332 |
|
| 1999 |
Hoffmann C, Moro S, Nicholas RA, Harden TK, Jacobson KA. The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. The Journal of Biological Chemistry. 274: 14639-47. PMID 10329657 DOI: 10.1074/Jbc.274.21.14639 |
0.635 |
|
| 1999 |
Nandanan E, Camaioni E, Jang SY, Kim YC, Cristalli G, Herdewijn P, Secrist JA, Tiwari KN, Mohanram A, Harden TK, Boyer JL, Jacobson KA. Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. Journal of Medicinal Chemistry. 42: 1625-38. PMID 10229631 DOI: 10.1021/Jm980657J |
0.6 |
|
| 1998 |
Kim YC, Camaioni E, Ziganshin AU, Ji XD, King BF, Wildman SS, Rychkov A, Yoburn J, Kim H, Mohanram A, Harden TK, Boyer JL, Burnstock G, Jacobson KA. Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. Drug Development Research. 45: 52-66. PMID 22922976 DOI: 10.1002/(Sici)1098-2299(199810)45:2<52::Aid-Ddr2>3.0.Co;2-V |
0.621 |
|
| 1998 |
Palmer RK, Boyer JL, Schachter JB, Nicholas RA, Harden TK. Agonist action of adenosine triphosphates at the human P2Y1 receptor Molecular Pharmacology. 54: 1118-1123. PMID 9855642 |
0.446 |
|
| 1998 |
Li Q, Olesky M, Palmer RK, Harden TK, Nicholas RA. Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor. Molecular Pharmacology. 54: 541-6. PMID 9730913 DOI: 10.1124/Mol.54.3.541 |
0.468 |
|
| 1998 |
Sromek SM, Harden TK. Agonist-induced internalization of the P2Y2 receptor. Molecular Pharmacology. 54: 485-94. PMID 9730907 DOI: 10.1124/MOL.54.3.485 |
0.47 |
|
| 1998 |
Jacobson KA, Kim YC, Wildman SS, Mohanram A, Harden TK, Boyer JL, King BF, Burnstock G. A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. Journal of Medicinal Chemistry. 41: 2201-6. PMID 9632352 DOI: 10.1021/Jm980183O |
0.565 |
|
| 1998 |
Boyer JL, Mohanram A, Camaioni E, Jacobson KA, Harden TK. Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. British Journal of Pharmacology. 124: 1-3. PMID 9630335 DOI: 10.1038/Sj.Bjp.0701837 |
0.644 |
|
| 1998 |
Moro S, Guo D, Camaioni E, Boyer JL, Harden TK, Jacobson KA. Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. Journal of Medicinal Chemistry. 41: 1456-66. PMID 9554879 DOI: 10.1021/Jm970684U |
0.626 |
|
| 1998 |
Camaioni E, Boyer JL, Mohanram A, Harden TK, Jacobson KA. Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. Journal of Medicinal Chemistry. 41: 183-90. PMID 9457242 DOI: 10.1021/jm970433l |
0.593 |
|
| 1998 |
Boyer JL, Waldo GL, Harden TK. Molecular cloning and expression of an avian G protein-coupled P2Y receptor. Molecular Pharmacology. 52: 928-34. PMID 9415702 DOI: 10.1124/MOL.52.6.928 |
0.489 |
|
| 1998 |
Palmer RK, Boyer JL, Schachter JB, Nicholas RA, Harden TK. Agonist Action of Adenosine Triphosphates at the Human P2Y1 Receptor Molecular Pharmacology. 54: 1118-1123. DOI: 10.1124/Mol.54.6.1118 |
0.534 |
|
| 1997 |
Schachter JB, Boyer JL, Li Q, Nicholas RA, Harden TK. Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C British Journal of Pharmacology. 122: 1021-1024. PMID 9401764 DOI: 10.1038/Sj.Bjp.0701479 |
0.549 |
|
| 1997 |
Schachter JB, Sromek SM, Nicholas RA, Harden TK. HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors Neuropharmacology. 36: 1181-1187. PMID 9364473 DOI: 10.1016/S0028-3908(97)00138-X |
0.548 |
|
| 1997 |
Lazarowski ER, Homolya L, Boucher RC, Harden TK. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. The Journal of Biological Chemistry. 272: 24348-54. PMID 9305892 DOI: 10.1074/Jbc.272.39.24348 |
0.521 |
|
| 1997 |
Jiang Q, Guo D, Lee BX, Van Rhee AM, Kim YC, Nicholas RA, Schachter JB, Harden TK, Jacobson KA. A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. Molecular Pharmacology. 52: 499-507. PMID 9281613 DOI: 10.1124/Mol.52.3.499 |
0.635 |
|
| 1997 |
Lazarowski ER, Homolya L, Boucher RC, Harden TK. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. The Journal of Biological Chemistry. 272: 20402-7. PMID 9252347 DOI: 10.1074/Jbc.272.33.20402 |
0.504 |
|
| 1997 |
Li Q, Schachter JB, Harden TK, Nicholas RA. The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses Biochemical and Biophysical Research Communications. 236: 455-460. PMID 9240460 DOI: 10.1006/Bbrc.1997.6984 |
0.573 |
|
| 1997 |
Herold CL, Li Q, Schachter JB, Harden TK, Nicholas RA. Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7. Biochemical and Biophysical Research Communications. 235: 717-21. PMID 9207227 DOI: 10.1006/Bbrc.1997.6884 |
0.566 |
|
| 1997 |
Schachter JB, Harden TK. An examination of deoxyadenosine 5′(α‐thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor British Journal of Pharmacology. 121: 338-344. PMID 9154346 DOI: 10.1038/Sj.Bjp.0701136 |
0.573 |
|
| 1997 |
Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M. Towards a revised nomenclature for P1 and P2 receptors. Trends in Pharmacological Sciences. 18: 79-82. PMID 9133776 DOI: 10.1016/S0165-6147(96)01038-3 |
0.587 |
|
| 1997 |
Lazarowski ER, Paradiso AM, Watt WC, Harden TK, Boucher RC. UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 2599-603. PMID 9122241 DOI: 10.1073/Pnas.94.6.2599 |
0.479 |
|
| 1997 |
Harden TK, Lazarowski ER, Boucher RC. Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity. Trends in Pharmacological Sciences. 18: 43-6. PMID 9090307 |
0.346 |
|
| 1997 |
Galas MC, Harden TK. Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes. European Journal of Pharmacology. 314: 157-64. PMID 8957232 DOI: 10.1016/S0014-2999(96)00524-9 |
0.473 |
|
| 1997 |
Harden T, Lazarowski ER, Boucher RC. Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity Trends in Pharmacological Sciences. 18: 43-46. DOI: 10.1016/S0165-6147(97)89795-7 |
0.56 |
|
| 1996 |
Nicholas RA, Lazarowski ER, Watt WC, Li Q, Boyer J, Harden TK. Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. Journal of Autonomic Pharmacology. 16: 319-23. PMID 9131407 DOI: 10.1111/J.1474-8673.1996.Tb00044.X |
0.523 |
|
| 1996 |
Boyer JL, Romero-Avila T, Schachter JB, Harden TK. Identification of competitive antagonists of the P2Y1 receptor. Molecular Pharmacology. 50: 1323-9. PMID 8913364 |
0.524 |
|
| 1996 |
O'Grady SM, Elmquist E, Filtz TM, Nicholas RA, Harden TK. A guanine nucleotide-independent inwardly rectifying cation permeability is associated with P2Y1 receptor expression in Xenopus oocytes Journal of Biological Chemistry. 271: 29080-29087. PMID 8910562 DOI: 10.1074/Jbc.271.46.29080 |
0.525 |
|
| 1996 |
Boyer JL, Siddiqi S, Fischer B, Romero-Avila T, Jacobson KA, Harden TK. Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate. British Journal of Pharmacology. 118: 1959-64. PMID 8864529 DOI: 10.1111/j.1476-5381.1996.tb15630.x |
0.609 |
|
| 1996 |
Schachter JB, Li Q, Boyer JL, Nicholas RA, Harden TK. Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor British Journal of Pharmacology. 118: 167-173. PMID 8733591 DOI: 10.1111/J.1476-5381.1996.Tb15381.X |
0.477 |
|
| 1996 |
Galas MC, Harden TK. Receptor-induced heterologous desensitization of receptor-regulated phospholipase C. European Journal of Pharmacology. 291: 175-82. PMID 8566168 DOI: 10.1016/0922-4106(95)90140-X |
0.48 |
|
| 1996 |
Fredholm BB, Burnstock G, Harden TK, Spedding M. Receptor nomenclature Drug Development Research. 39: 461-466. DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<461::aid-ddr28>3.0.co;2-2 |
0.434 |
|
| 1996 |
Boyer JL, Schachter JB, Sromek SM, Palmer RK, Jacobson KA, Nicholas RA, Harden TK. Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties Drug Development Research. 39: 253-261. DOI: 10.1002/(Sici)1098-2299(199611/12)39:3/4<253::Aid-Ddr4>3.0.Co;2-Q |
0.659 |
|
| 1995 |
Boyer JL, O'Tuel JW, Fischer B, Jacobson KA, Harden TK. Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors. British Journal of Pharmacology. 116: 2611-6. PMID 8590978 DOI: 10.1111/J.1476-5381.1995.Tb17215.X |
0.605 |
|
| 1995 |
Lazarowski ER, Watt WC, Stutts MJ, Boucher RC, Harden TK. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. British Journal of Pharmacology. 116: 1619-27. PMID 8564228 DOI: 10.1111/J.1476-5381.1995.Tb16382.X |
0.493 |
|
| 1994 |
Burnstock G, Fischer B, Hoyle CH, Maillard M, Ziganshin AU, Brizzolara AL, von Isakovics A, Boyer JL, Harden TK, Jacobson KA. Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. Drug Development Research. 31: 206-219. PMID 22962511 DOI: 10.1002/Ddr.430310308 |
0.468 |
|
| 1994 |
Boyer JL, Lazarowski ER, Chen XH, Harden TK. Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. The Journal of Pharmacology and Experimental Therapeutics. 267: 1140-6. PMID 8263774 |
0.507 |
|
| 1994 |
Lazarowski ER, Harden TK. Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. The Journal of Biological Chemistry. 269: 11830-6. PMID 8163481 |
0.494 |
|
| 1994 |
Filtz TM, Li Q, Boyer JL, Nicholas RA, Harden TK. Expression of a cloned P(2Y) purinergic receptor that couples to phospholipase C Molecular Pharmacology. 46: 8-14. PMID 8058061 |
0.464 |
|
| 1994 |
Chen XH, Harden TK, Nicholas RA. Molecular cloning and characterization of a novel β-adrenergic receptor Journal of Biological Chemistry. 269: 24810-24819. PMID 7929160 |
0.319 |
|
| 1994 |
Boyer JL, Zohn IE, Jacobson KA, Harden TK. Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. British Journal of Pharmacology. 113: 614-20. PMID 7834215 DOI: 10.1111/J.1476-5381.1994.Tb17034.X |
0.535 |
|
| 1993 |
Fischer B, Boyer JL, Hoyle CH, Ziganshin AU, Brizzolara AL, Knight GE, Zimmet J, Burnstock G, Harden TK, Jacobson KA. Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. Journal of Medicinal Chemistry. 36: 3937-46. PMID 8254622 DOI: 10.1021/Jm00076A023 |
0.561 |
|
| 1992 |
Lazarowski ER, Mason SJ, Clarke L, Harden TK, Boucher RC. Adenosine receptors on human airway epithelia and their relationship to chloride secretion. British Journal of Pharmacology. 106: 774-82. PMID 1327386 DOI: 10.1111/J.1476-5381.1992.Tb14412.X |
0.379 |
|
| 1991 |
Brown HA, Lazarowski ER, Boucher RC, Harden TK. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. Molecular Pharmacology. 40: 648-55. PMID 1944236 |
0.381 |
|
| 1991 |
Harden TK, Morris AJ, Waldo GL, Downes CP, Boyer JL. Avian G-protein-regulated phospholipase C. Biochemical Society Transactions. 19: 342-6. PMID 1909665 DOI: 10.1042/Bst0190342 |
0.305 |
|
| 1991 |
Jeffs RA, Cooper CL, Harden TK. Solubilization of a guanine nucleotide-sensitive form of the P2Y-purinergic receptor. Molecular Pharmacology. 40: 85-92. PMID 1906978 |
0.413 |
|
| 1990 |
Harden TK, Boyer JL, Brown HA, Cooper CL, Jeffs RA, Martin MW. Biochemical properties of a P2Y-purinergic receptor. Annals of the New York Academy of Sciences. 603: 256-66. PMID 2291525 DOI: 10.1111/J.1749-6632.1990.Tb37677.X |
0.548 |
|
| 1990 |
Boyer JL, Cooper CL, Harden TK. [32P]3'-O-(4-benzoyl)benzoyl ATP as a photoaffinity label for a phospholipase C-coupled P2Y-purinergic receptor. The Journal of Biological Chemistry. 265: 13515-20. PMID 2199438 |
0.309 |
|
| 1990 |
Morris AJ, Waldo GL, Downes CP, Harden TK. A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts. The Journal of Biological Chemistry. 265: 13508-14. PMID 2166033 |
0.373 |
|
| 1990 |
Harden TK. G protein-dependent regulation of phospholipase C by cell surface receptors. The American Review of Respiratory Disease. 141: S119-22. PMID 2155558 DOI: 10.1164/ajrccm/141.3_Pt_2.S119 |
0.38 |
|
| 1990 |
Morris AJ, Waldo GL, Boyer JL, Hepler JR, Downes CP, Harden TK. Regulation of phospholipase C. Society of General Physiologists Series. 45: 61-75. PMID 2116041 |
0.527 |
|
| 1990 |
Huckle WR, Hepler JR, Rhee SG, Harden TK, Earp HS. Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis. Endocrinology. 127: 1697-705. PMID 1698145 DOI: 10.1210/Endo-127-4-1697 |
0.655 |
|
| 1990 |
Hepler JR, Jeffs RA, Huckle WR, Outlaw HE, Rhee SG, Earp HS, Harden TK. Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. The Biochemical Journal. 270: 337-44. PMID 1698055 DOI: 10.1042/Bj2700337 |
0.658 |
|
| 1990 |
BOYER JL, COOPER CL, HARDEN TK. Irreversible Activation and Photoaffinity Labeling of a P2Y-Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes Annals of the New York Academy of Sciences. 603: 478-479. DOI: 10.1111/J.1749-6632.1990.Tb37711.X |
0.464 |
|
| 1990 |
JEFFS RA, COOPER CL, BOYER JL, HARDEN TK. Solubilization of a Guanine Nucleotide-Sensitive Form of the P2Y-Purinergic Receptor from Turkey Erythrocyte Membranes Annals of the New York Academy of Sciences. 603: 476-477. DOI: 10.1111/j.1749-6632.1990.tb37710.x |
0.339 |
|
| 1989 |
Boyer JL, Downes CP, Harden TK. Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. The Journal of Biological Chemistry. 264: 884-90. PMID 2910869 |
0.391 |
|
| 1989 |
Downes CP, Berrie CP, Hawkins PT, Stephens L, Boyer JL, Harden TK. Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 320: 267-80. PMID 2906138 DOI: 10.1098/rstb.1988.0076 |
0.339 |
|
| 1989 |
Roe MW, Hepler JR, Harden TK, Herman B. Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells. Journal of Cellular Physiology. 139: 100-8. PMID 2708448 DOI: 10.1002/Jcp.1041390115 |
0.591 |
|
| 1989 |
Boyer JL, Harden TK. Irreversible activation of phospholipase C-coupled P(2γ)-purinergic receptors by 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate Molecular Pharmacology. 36: 831-835. PMID 2689859 |
0.401 |
|
| 1989 |
Boyer JL, Hepler JR, Harden TK. Hormone and growth factor receptor-mediated regulation of phospholipase C activity. Trends in Pharmacological Sciences. 10: 360-4. PMID 2557690 DOI: 10.1016/0165-6147(89)90008-4 |
0.696 |
|
| 1989 |
Martin MW, Harden TK. Agonist-induced desensitization of a P(2Y)-purinergic receptor-regulated phospholipase C Journal of Biological Chemistry. 264: 19535-19539. PMID 2555322 |
0.468 |
|
| 1989 |
Boyer JL, Waldo GL, Evans T, Northup JK, Downes CP, Harden TK. Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. The Journal of Biological Chemistry. 264: 13917-22. PMID 2503507 |
0.336 |
|
| 1989 |
Cooper CL, Morris AJ, Harden TK. Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor. The Journal of Biological Chemistry. 264: 6202-6. PMID 2495280 |
0.414 |
|
| 1988 |
Abramson SN, Martin MW, Hughes AR, Harden TK, Neve KA, Barrett DA, Molinoff PB. Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. Biochemical Pharmacology. 37: 4289-97. PMID 2848525 DOI: 10.1016/0006-2952(88)90609-0 |
0.418 |
|
| 1988 |
Hepler JR, Earp HS, Harden TK. Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. The Journal of Biological Chemistry. 263: 7610-9. PMID 2836390 |
0.616 |
|
| 1987 |
Nakahata N, Harden TK. Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. The Biochemical Journal. 241: 337-44. PMID 3593197 DOI: 10.1042/bj2410337 |
0.442 |
|
| 1987 |
Liang M, Martin MW, Harden TK. [3H]Propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines Molecular Pharmacology. 32: 443-449. PMID 3118180 |
0.343 |
|
| 1987 |
Hepler JR, Nakahata N, Lovenberg TW, DiGuiseppi J, Herman B, Earp HS, Harden TK. Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. The Journal of Biological Chemistry. 262: 2951-6. PMID 3102480 |
0.574 |
|
| 1987 |
Hepler JR, Hughes AR, Harden TK. Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. The Biochemical Journal. 247: 793-6. PMID 2827638 DOI: 10.1042/Bj2470793 |
0.651 |
|
| 1987 |
Pallotta BS, Hepler JR, Oglesby SA, Harden TK. A comparison of calcium-activated potassium channel currents in cell-attached and excised patches. The Journal of General Physiology. 89: 985-97. PMID 2440980 DOI: 10.1085/Jgp.89.6.985 |
0.538 |
|
| 1986 |
Hepler JR, Harden TK. Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. The Biochemical Journal. 239: 141-6. PMID 3800973 DOI: 10.1042/Bj2390141 |
0.668 |
|
| 1986 |
Harden TK, Heng MM, Brown JH. Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment. Molecular Pharmacology. 30: 200-6. PMID 3018476 |
0.482 |
|
| 1986 |
Toews ML, Waldo GL, Harden TK, Perkins JP. Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37° and on ice Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 11: 47-62. PMID 3009571 |
0.352 |
|
| 1986 |
Tanner LI, Harden TK, Wells JN, Martin MW. Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. Molecular Pharmacology. 29: 455-60. PMID 2422535 |
0.479 |
|
| 1986 |
Hughes AR, Harden TK. Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. The Journal of Pharmacology and Experimental Therapeutics. 237: 173-8. PMID 2420967 |
0.464 |
|
| 1986 |
Nakahata N, Martin MW, Hughes AR, Hepler JR, Harden TK. H1-histamine receptors on human astrocytoma cells. Molecular Pharmacology. 29: 188-95. PMID 2419744 |
0.69 |
|
| 1985 |
Harden TK, Petch LA, Traynelis SF, Waldo GL. Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. The Journal of Biological Chemistry. 260: 13060-6. PMID 4055732 |
0.422 |
|
| 1985 |
Martin MW, Evans T, Harden TK. Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not N(i) Biochemical Journal. 229: 539-544. PMID 3929772 DOI: 10.1042/bj2290539 |
0.413 |
|
| 1985 |
Evans T, Hepler JR, Masters SB, Brown JH, Harden TK. Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. The Biochemical Journal. 232: 751-7. PMID 3004418 |
0.676 |
|
| 1985 |
Masters SB, Martin MW, Harden TK, Brown JH. Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization Biochemical Journal. 227: 933-937. PMID 2988509 DOI: 10.1042/bj2270933 |
0.454 |
|
| 1985 |
Harden TK, Evans T, Hepler JR, Hughes AR, Martin MW, Meeker RB, Smith MM, Tanner LI. Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 207-20. PMID 2988297 |
0.697 |
|
| 1985 |
Evans T, Martin MW, Hughes AR, Harden TK. Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin Molecular Pharmacology. 27: 32-37. PMID 2981400 |
0.423 |
|
| 1984 |
Cubaddu LX, Cloutier G, Gross K, Grippo R, Tanner L, Lerea L, Shakarjian M, Knowlton G, Harden TK, Arerlishorat W, Rogers JF. Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and sponteneously hypertensive rats Clinical Pharmacology and Therapeutics. 35: 576-584. PMID 6424997 DOI: 10.1038/Clpt.1984.80 |
0.315 |
|
| 1984 |
Martin MW, Smith MM, Harden TK. Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart Journal of Pharmacology and Experimental Therapeutics. 230: 424-430. PMID 6379149 |
0.314 |
|
| 1984 |
Trimmer PA, Evans T, Smith MM, Harden TK, McCarthy KD. Combination of immunocytochemistry and radioligand receptor assay to identify beta-adrenergic receptor subtypes on astroglia in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 1598-606. PMID 6327938 |
0.341 |
|
| 1984 |
Smith MM, Harden TK. Modification of receptor-mediated inhibition of adenylate cyclase in NG 108-15 neuroblastoma x glioma cells by N-ethylmaleimide Journal of Pharmacology and Experimental Therapeutics. 228: 425-433. PMID 6319678 |
0.453 |
|
| 1984 |
Evans T, McCarthy KD, Harden TK. Regulation of cyclic AMP accumulation by peptide hormone receptors in immunocytochemically defined astroglial cells. Journal of Neurochemistry. 43: 131-8. PMID 6202841 DOI: 10.1111/j.1471-4159.1984.tb06688.x |
0.39 |
|
| 1984 |
Waldo GL, Doss RC, Perkins JP, Harden TK. Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells. Molecular Pharmacology. 26: 424-9. PMID 6092895 |
0.38 |
|
| 1984 |
Evans T, Smith MM, Tanner LI, Harden TK. Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms. Molecular Pharmacology. 26: 395-404. PMID 6092892 |
0.398 |
|
| 1984 |
Hughes AR, Martin MW, Harden TK. Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors Proceedings of the National Academy of Sciences of the United States of America. 81: 5680-5684. PMID 6091103 DOI: 10.1073/pnas.81.18.5680 |
0.386 |
|
| 1984 |
Toews ML, Waldo GL, Harden TK, Perkins JP. Relationship between an altered membrane form and a low affinity form of the β-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization Journal of Biological Chemistry. 259: 11844-11850. PMID 6090447 |
0.432 |
|
| 1983 |
Harden TK, Meeker RB, Martin MW. Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors. The Journal of Pharmacology and Experimental Therapeutics. 227: 570-7. PMID 6317839 |
0.307 |
|
| 1983 |
Frederich RC, Waldo GL, Harden TK, Perkins JP. Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 9: 103-18. PMID 6315795 |
0.354 |
|
| 1983 |
Waldo GL, Northup JK, Perkins JP, Harden TK. Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. The Journal of Biological Chemistry. 258: 13900-8. PMID 6315711 |
0.421 |
|
| 1983 |
Meeker RB, Harden TK. Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation. Molecular Pharmacology. 23: 384-92. PMID 6300648 |
0.474 |
|
| 1983 |
Harden TK. Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. Pharmacological Reviews. 35: 5-32. PMID 6138782 |
0.364 |
|
| 1983 |
Toews ML, Harden TK, Perkins JP. High-affinity binding of agonists to β-adrenergic receptors on intact cells Proceedings of the National Academy of Sciences of the United States of America. 80: 3553-3557. PMID 6134286 |
0.332 |
|
| 1982 |
Witkin KM, Harden TK. A sensitive equilibrium binding assay for soluble beta-adrenergic receptors. Journal of Cyclic Nucleotide Research. 7: 235-46. PMID 6278007 |
0.425 |
|
| 1982 |
Meeker RB, Harden TK. Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. Molecular Pharmacology. 22: 310-9. PMID 6183568 |
0.439 |
|
| 1981 |
Doss RC, Perkins JP, Harden TK. Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. The Journal of Biological Chemistry. 256: 12281-6. PMID 6271779 |
0.43 |
|
| 1981 |
Wolfe BB, Harden TK. Guanine nucleotides modulate the affinity of antagonists at beta-adrenergic receptors. Journal of Cyclic Nucleotide Research. 7: 303-12. PMID 6124564 |
0.404 |
|
| 1980 |
Harden TK, Cotton CU, Waldo GL, Lutton JK, Perkins JP. Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. Science (New York, N.Y.). 210: 441-3. PMID 6254143 DOI: 10.1126/science.6254143 |
0.424 |
|
| 1980 |
Thurman RG, Harden TK, Winn K. Cyclic AMP and beta-adrenergic receptors during the development of physical dependence on ethanol in the rat. Advances in Experimental Medicine and Biology. 126: 145-55. PMID 6250327 DOI: 10.1007/978-1-4684-3632-7_14 |
0.309 |
|
| 1979 |
Hunt WA, Harden TK, Thurman RG. beta-adrenergic receptor density in brains of ethanol-dependent rats. Drug and Alcohol Dependence. 4: 327. PMID 230952 DOI: 10.1016/0376-8716(79)90015-2 |
0.34 |
|
| 1979 |
Harden TK, Su YF, Perkins JP. Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. Journal of Cyclic Nucleotide Research. 5: 99-106. PMID 221555 |
0.385 |
|
| 1979 |
Harden TK, Mailman RB, Mueller RA, Breese GR. Noradrenergic hyperinnervation reduces the density of beta-adrenergic receptors in rat cerebellum. Brain Research. 166: 194-8. PMID 217500 DOI: 10.1016/0006-8993(79)90664-4 |
0.376 |
|
| 1979 |
Su YF, Harden TK, Perkins JP. Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. The Journal of Biological Chemistry. 254: 38-41. PMID 214444 |
0.348 |
|
| 1979 |
Perkins JP, Su YF, Harden TK. Adaptive changes in the responsiveness of adenylate cyclase to catecholamines. Drug and Alcohol Dependence. 4: 279-94. PMID 43242 DOI: 10.1016/0376-8716(79)90011-5 |
0.496 |
|
| 1978 |
Wolfe BB, Harden TK, Sporn JR, Molinoff PB. Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. The Journal of Pharmacology and Experimental Therapeutics. 207: 446-57. PMID 213556 |
0.334 |
|
| 1978 |
Leichtling BH, Su YF, Wimalasena J, Harden TK, Wolfe BB, Wicks WD. Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness. Journal of Cellular Physiology. 96: 215-23. PMID 209052 DOI: 10.1002/Jcp.1040960210 |
0.337 |
|
| 1978 |
Johnson GL, Wolfe BB, Harden TK, Molinoff PB, Perkins JP. Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells. The Journal of Biological Chemistry. 253: 1472-80. PMID 203594 |
0.349 |
|
| 1978 |
Johnson GL, Harden TK, Perkins JP. Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins. The Journal of Biological Chemistry. 253: 1465-71. PMID 203593 |
0.381 |
|
| 1977 |
Harden TK, Wolfe BB, Sporn JR, Perkins JP, Molinoff PB. Ontogeny of beta-adrenergic receptors in rat cerebral cortex. Brain Research. 125: 99-108. PMID 192417 DOI: 10.1016/0006-8993(77)90362-6 |
0.318 |
|
| 1977 |
Wolfe BB, Harden TK, Molinoff PB. In vitro study of beta-adrenergic receptors. Annual Review of Pharmacology and Toxicology. 17: 575-604. PMID 17362 DOI: 10.1146/Annurev.Pa.17.040177.003043 |
0.316 |
|
| 1976 |
Wolfe BB, Harden TK, Molinoff PB. beta-adrenergic receptors in rat liver: effects of adrenalectomy. Proceedings of the National Academy of Sciences of the United States of America. 73: 1343-7. PMID 4798 DOI: 10.1073/Pnas.73.4.1343 |
0.313 |
|
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