John E. Sondek - Publications

Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Molecular Biology, Genetics, Microbiology Biology

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hajicek N, Keith NC, Siraliev-Perez E, Temple BRS, Huang W, Zhang Q, Harden TK, Sondek J. Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations. Elife. 8. PMID 31889510 DOI: 10.7554/eLife.51700  0.44
2019 Hajicek N, Keith NC, Siraliev-Perez E, Temple BR, Huang W, Zhang Q, Harden TK, Sondek J. Author response: Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations Elife. DOI: 10.7554/Elife.51700.Sa2  0.44
2019 Hajicek N, Keith NC, Siraliev-Perez E, Temple BRS, Huang W, Zhang Q, Harden TK, Sondek J. Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife. 8. DOI: 10.2210/Pdb6Pbc/Pdb  0.44
2017 Huang W, Wang X, Endo-Streeter S, Barrett M, Waybright J, Wohlfeld C, Hajicek N, Harden TK, Sondek J, Zhang Q. A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes. The Journal of Biological Chemistry. PMID 29263090 DOI: 10.1074/Jbc.Ra117.000926  0.44
2016 Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J. Potent and Selective Peptide-based Inhibition of the G protein Gαq. The Journal of Biological Chemistry. PMID 27742837 DOI: 10.1074/Jbc.M116.740407  0.44
2016 Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, González-Porras JR, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, et al. Novel mutations in RASGRP2 encoding for CalDAG-GEFI abrogate Rap1 activation causing platelet dysfunction. Blood. PMID 27235135 DOI: 10.1182/Blood-2015-11-683102  0.72
2016 Ren J, Cook AA, Bergmeier W, Sondek J. A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation. Biochemical and Biophysical Research Communications. 474: 193-8. PMID 27107697 DOI: 10.1016/J.Bbrc.2016.04.100  0.72
2015 Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, ... ... Sondek J, et al. The experimental power of FR900359 to study Gq-regulated biological processes. Nature Communications. 6: 10156. PMID 26658454 DOI: 10.1038/Ncomms10156  0.44
2014 Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J. Membrane-induced allosteric control of phospholipase C-β isozymes. The Journal of Biological Chemistry. 289: 29545-57. PMID 25193662 DOI: 10.1074/Jbc.M114.586784  0.72
2014 Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, ... ... Sondek J, et al. A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation. Chemistry & Biology. 21: 890-902. PMID 25036778 DOI: 10.1016/J.Chembiol.2014.06.003  0.72
2013 Kimple ME, Brill AL, Pasker RL. Overview of affinity tags for protein purification. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 73: Unit 9.9. PMID 24510596 DOI: 10.1002/0471140864.Ps0909S73  0.68
2013 Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. Biochemistry. 52: 4810-9. PMID 23777354 DOI: 10.1021/Bi400433B  0.72
2013 Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q. Small molecule inhibitors of phospholipase C from a novel high-throughput screen. The Journal of Biological Chemistry. 288: 5840-8. PMID 23297405 DOI: 10.1074/Jbc.M112.422501  0.72
2013 Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J. Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry. 52: 4810-4819. DOI: 10.2210/Pdb4K44/Pdb  0.44
2012 Fernandez-Piñar P, Alemán A, Sondek J, Dohlman HG, Molina M, Martín H. The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae. Molecular Biology of the Cell. 23: 4430-43. PMID 23015760 DOI: 10.1091/Mbc.E12-03-0243  0.72
2012 Cherkis KA, Temple BR, Chung EH, Sondek J, Dangl JL. AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana. Plos One. 7: e42633. PMID 22880057 DOI: 10.1371/Journal.Pone.0042633  0.72
2012 Wang X, Barrett M, Sondek J, Harden TK, Zhang Q. Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. Biochemistry. 51: 5300-6. PMID 22703043 DOI: 10.1021/Bi300637H  0.44
2012 Gresset A, Sondek J, Harden TK. The phospholipase C isozymes and their regulation. Sub-Cellular Biochemistry. 58: 61-94. PMID 22403074 DOI: 10.1007/978-94-007-3012-0_3  0.44
2011 Tang W, Zhang Y, Xu W, Harden TK, Sondek J, Sun L, Li L, Wu D. A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Developmental Cell. 21: 1038-50. PMID 22172670 DOI: 10.1016/J.Devcel.2011.10.023  0.44
2011 Harden TK, Waldo GL, Hicks SN, Sondek J. Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. Chemical Reviews. 111: 6120-9. PMID 21988240 DOI: 10.1021/Cr200209P  0.72
2011 Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR. Direct activation of human phospholipase C by its well known inhibitor u73122. The Journal of Biological Chemistry. 286: 12407-16. PMID 21266572 DOI: 10.1074/Jbc.M110.191783  0.72
2011 Hamel B, Monaghan-Benson E, Rojas RJ, Temple BR, Marston DJ, Burridge K, Sondek J. SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. The Journal of Biological Chemistry. 286: 12141-8. PMID 21242305 DOI: 10.1074/Jbc.M110.191122  0.72
2011 Huang W, Hicks SN, Sondek J, Zhang Q. A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. Acs Chemical Biology. 6: 223-8. PMID 21158426 DOI: 10.1021/Cb100308N  0.72
2010 Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK. Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (New York, N.Y.). 330: 974-80. PMID 20966218 DOI: 10.1126/Science.1193438  0.72
2010 Gresset A, Hicks SN, Harden TK, Sondek J. Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. The Journal of Biological Chemistry. 285: 35836-47. PMID 20807769 DOI: 10.1074/Jbc.M110.166512  0.72
2009 Friedman EJ, Temple BR, Hicks SN, Sondek J, Jones CD, Jones AM. Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain. Journal of Molecular Biology. 392: 1044-54. PMID 19646992 DOI: 10.1016/J.Jmb.2009.07.076  0.72
2009 Heenan EJ, Vanhooke JL, Temple BR, Betts L, Sondek JE, Dohlman HG. Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry. 48: 6390-401. PMID 19445518 DOI: 10.1021/Bi900621W  0.72
2009 Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR. High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay. Journal of Biomolecular Screening. 14: 161-72. PMID 19196702 DOI: 10.1177/1087057108328761  0.72
2009 Harden TK, Hicks SN, Sondek J. Phospholipase C isozymes as effectors of Ras superfamily GTPases. Journal of Lipid Research. 50: S243-8. PMID 19033212 DOI: 10.1194/Jlr.R800045-Jlr200  0.44
2008 Seifert JP, Zhou Y, Hicks SN, Sondek J, Harden TK. Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. The Journal of Biological Chemistry. 283: 29690-8. PMID 18765661 DOI: 10.1074/Jbc.M805038200  0.44
2008 Hicks SN, Jezyk MR, Gershburg S, Seifert JP, Harden TK, Sondek J. General and versatile autoinhibition of PLC isozymes. Molecular Cell. 31: 383-94. PMID 18691970 DOI: 10.1016/J.Molcel.2008.06.018  0.72
2008 Yohe ME, Rossman K, Sondek J. Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins. Biochemistry. 47: 6827-39. PMID 18537266 DOI: 10.1021/Bi702543P  0.72
2008 Zhou Y, Sondek J, Harden TK. Activation of human phospholipase C-eta2 by Gbetagamma. Biochemistry. 47: 4410-7. PMID 18361507 DOI: 10.1021/Bi800044N  0.44
2008 Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J. Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nature Structural & Molecular Biology. 15: 155-62. PMID 18204463 DOI: 10.1038/Nsmb.1377  0.44
2007 Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nature Structural & Molecular Biology. 14: 814-23. PMID 17704816 DOI: 10.1038/Nsmb1290  0.72
2007 Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J. Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain. The Journal of Biological Chemistry. 282: 29201-10. PMID 17606614 DOI: 10.1074/Jbc.M703458200  0.72
2007 Desveaux D, Singer AU, Wu AJ, McNulty BC, Musselwhite L, Nimchuk Z, Sondek J, Dangl JL. Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. Plos Pathogens. 3: e48. PMID 17397263 DOI: 10.1371/Journal.Ppat.0030048  0.72
2007 Chhatriwala MK, Betts L, Worthylake DK, Sondek J. The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation. Journal of Molecular Biology. 368: 1307-20. PMID 17391702 DOI: 10.1016/J.Jmb.2007.02.060  0.72
2007 Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. The Journal of Biological Chemistry. 282: 13813-23. PMID 17337446 DOI: 10.1074/Jbc.M700185200  0.72
2007 Bencharit S, Cui CB, Siddiqui A, Howard-Williams EL, Sondek J, Zuobi-Hasona K, Aukhil I. Structural insights into fibronectin type III domain-mediated signaling. Journal of Molecular Biology. 367: 303-9. PMID 17261313 DOI: 10.1016/J.Jmb.2006.10.017  0.72
2006 Jezyk MR, Snyder JT, Gershberg S, Worthylake DK, Harden TK, Sondek J. Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nature Structural & Molecular Biology. 13: 1135-40. PMID 17115053 DOI: 10.1038/Nsmb1175  0.72
2006 Baumeister MA, Rossman KL, Sondek J, Lemmon MA. The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. The Biochemical Journal. 400: 563-72. PMID 17007612 DOI: 10.1042/Bj20061020  0.72
2006 Bourdon DM, Wing MR, Edwards EB, Sondek J, Harden TK. Quantification of isozyme-specific activation of phospholipase C-β2 by Rac GTPases and phospholipase C-ε by Rho GTPases in an intact cell assay system Methods in Enzymology. 406: 489-499. PMID 16472681 DOI: 10.1016/S0076-6879(06)06037-X  0.72
2006 Snyder JT, Jezyk MR, Gershburg S, Harden TK, Sondek J. Regulation of PLCbeta isoforms by Rac. Methods in Enzymology. 406: 272-80. PMID 16472664 DOI: 10.1016/S0076-6879(06)06020-4  0.72
2006 Seifert JP, Snyder JT, Sondek J, Harden TK. Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles. Methods in Enzymology. 406: 260-71. PMID 16472663 DOI: 10.1016/S0076-6879(06)06019-8  0.44
2006 Harden TK, Sondek J. Regulation of phospholipase C isozymes by ras superfamily GTPases. Annual Review of Pharmacology and Toxicology. 46: 355-79. PMID 16402909 DOI: 10.1146/Annurev.Pharmtox.46.120604.141223  0.44
2005 Smith WJ, Hamel B, Yohe ME, Sondek J, Cerione RA, Snyder JT. A Cdc42 mutant specifically activated by intersectin. Biochemistry. 44: 13282-90. PMID 16201754 DOI: 10.1021/Bi050591B  0.72
2005 Zhou Y, Wing MR, Sondek J, Harden TK. Molecular cloning and characterization of PLC-η2 Biochemical Journal. 391: 667-676. PMID 16107206 DOI: 10.1042/Bj20050839  0.72
2005 Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP. Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (London, England : 1993). 13: 1069-80. PMID 16004878 DOI: 10.1016/J.Str.2005.04.007  0.72
2005 Kim HS, Desveaux D, Singer AU, Patel P, Sondek J, Dangl JL. The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 6496-501. PMID 15845764 DOI: 10.1073/Pnas.0500792102  0.72
2005 Rossman KL, Sondek J. Larger than Dbl: new structural insights into RhoA activation. Trends in Biochemical Sciences. 30: 163-5. PMID 15817389 DOI: 10.1016/J.Tibs.2005.02.002  0.72
2005 Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS. A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Current Biology : Cb. 15: 371-7. PMID 15723800 DOI: 10.1016/J.Cub.2005.01.050  0.72
2005 Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Reviews. Molecular Cell Biology. 6: 167-80. PMID 15688002 DOI: 10.1038/Nrm1587  0.72
2005 Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. The Journal of Biological Chemistry. 280: 8407-15. PMID 15574431 DOI: 10.1074/Jbc.M411515200  0.72
2004 Kimple ME, Sondek J. Overview of affinity tags for protein purification. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 9.9. PMID 18429272 DOI: 10.1002/0471140864.ps0909s36  0.72
2004 deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Current Biology : Cb. 14: 2208-16. PMID 15620647 DOI: 10.1016/J.Cub.2004.12.029  0.72
2004 Singh A, Karnoub AE, Palmby TR, Lengyel E, Sondek J, Der CJ. Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene. 23: 9369-80. PMID 15516977 DOI: 10.1038/Sj.Onc.1208182  0.72
2004 Singer AU, Desveaux D, Betts L, Chang JH, Nimchuk Z, Grant SR, Dangl JL, Sondek J. Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis. Structure (London, England : 1993). 12: 1669-81. PMID 15341731 DOI: 10.1016/J.Str.2004.06.023  0.72
2004 Seifert JP, Wing MR, Snyder JT, Gershburg S, Sondek J, Harden TK. RhoA activates purified phospholipase C-ε by a guanine nucleotide-dependent mechanism Journal of Biological Chemistry. 279: 47992-47997. PMID 15322077 DOI: 10.1074/Jbc.M407111200  0.72
2004 Worthylake DK, Rossman KL, Sondek J. Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure (London, England : 1993). 12: 1078-86. PMID 15274927 DOI: 10.1016/J.Str.2004.03.021  0.72
2004 Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS. PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nature Structural & Molecular Biology. 11: 756-62. PMID 15247908 DOI: 10.1038/Nsmb800  0.72
2004 Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ. Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. The Journal of Biological Chemistry. 279: 25226-33. PMID 15073184 DOI: 10.1074/Jbc.M313792200  0.72
2004 Chen Y, Vallee S, Wu J, Vu D, Sondek J, Ghosh G. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Molecular and Cellular Biology. 24: 3048-56. PMID 15024091 DOI: 10.1128/Mcb.24.7.3048-3056.2004  0.72
2003 Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. The Journal of Biological Chemistry. 278: 49031-43. PMID 14506234 DOI: 10.1074/Jbc.M308104200  0.72
2003 Wing MR, Snyder JT, Sondek J, Harden TK. Direct Activation of Phospholipase C-ε by Rho Journal of Biological Chemistry. 278: 41253-41258. PMID 12900402 DOI: 10.1074/Jbc.M306904200  0.72
2003 Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J. Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Combinatorial Chemistry & High Throughput Screening. 6: 409-18. PMID 12769685 DOI: 10.2174/138620703106298509  0.72
2003 Pruitt WM, Karnoub AE, Rakauskas AC, Guipponi M, Antonarakis SE, Kurakin A, Kay BK, Sondek J, Siderovski DP, Der CJ. Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling. Biochimica Et Biophysica Acta. 1640: 61-8. PMID 12676355 DOI: 10.1016/S0167-4889(03)00002-8  0.72
2003 Snyder JT, Singer AU, Wing MR, Harden TK, Sondek J. The pleckstrin homology domain of phospholipase C-β2 as an effector site for Rac Journal of Biological Chemistry. 278: 21099-21104. PMID 12657629 DOI: 10.1074/Jbc.M301418200  0.72
2003 Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J. Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. The Journal of Biological Chemistry. 278: 18393-400. PMID 12637522 DOI: 10.1074/Jbc.M300127200  0.72
2003 Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. The Journal of Biological Chemistry. 278: 11457-64. PMID 12525493 DOI: 10.1074/Jbc.M211901200  0.72
2003 Snyder JT, Rossman KL, Worthylake DK, Sondek J. Structural features of RhoGEFs Handbook of Cell Signaling. 2: 751-755. DOI: 10.1016/B978-012124546-7/50607-0  0.72
2002 Rossman KL, Worthylake DK, Snyder JT, Cheng L, Whitehead IP, Sondek J. Functional analysis of cdc42 residues required for Guanine nucleotide exchange. The Journal of Biological Chemistry. 277: 50893-8. PMID 12401782 DOI: 10.1074/Jbc.M208580200  0.72
2002 Kimple ME, Sondek J. Affinity tag for protein purification and detection based on the disulfide-linked complex of InaD and NorpA. Biotechniques. 33: 578, 580, 584-8 pass. PMID 12238768 DOI: 10.2144/02333Rr01  0.72
2002 Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP. RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity. Molecular and Cellular Biology. 22: 6895-905. PMID 12215546 DOI: 10.1128/Mcb.22.19.6895-6905.2002  0.72
2002 Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nature Cell Biology. 4: 621-5. PMID 12134164 DOI: 10.1038/Ncb833  0.72
2002 Barry WT, Boudignon-Proudhon C, Shock DD, McFadden A, Weiss JM, Sondek J, Parise LV. Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. The Journal of Biological Chemistry. 277: 28877-83. PMID 12023286 DOI: 10.1074/Jbc.M202983200  0.72
2002 Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology. 9: 468-75. PMID 12006984 DOI: 10.1038/Nsb796  0.72
2002 Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 416: 878-81. PMID 11976690 DOI: 10.1038/416878A  0.72
2002 Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J. A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. The Embo Journal. 21: 1315-26. PMID 11889037 DOI: 10.1093/Emboj/21.6.1315  0.72
2002 Siderovski DP, Snow BE, Chung S, Brothers GM, Sondek J, Betts L. Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits. Methods in Enzymology. 344: 702-23. PMID 11771422 DOI: 10.1016/S0076-6879(02)44750-7  0.72
2002 Singer AU, Waldo GL, Harden TK, Sondek J. A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nature Structural Biology. 9: 32-6. PMID 11753430 DOI: 10.1038/Nsb731  0.44
2001 Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ. Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nature Structural Biology. 8: 1037-41. PMID 11685227 DOI: 10.1038/Nsb719  0.72
2001 Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. The Journal of Biological Chemistry. 276: 45868-75. PMID 11577097 DOI: 10.1074/Jbc.M106731200  0.72
2001 Kimple ME, Siderovski DP, Sondek J. Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA Embo Journal. 20: 4414-4422. PMID 11500369 DOI: 10.1093/Emboj/20.16.4414  0.72
2001 Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ. Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA Journal of Biological Chemistry. 276: 27145-27151. PMID 11373293 DOI: 10.1074/Jbc.M103565200  0.72
2000 Worthylake DK, Rossman KL, Sondek J. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 Nature. 408: 682-688. PMID 11130063 DOI: 10.1038/35047014  0.72
1999 Shock DD, Naik UP, Brittain JE, Alahari SK, Sondek J, Parise LV. Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton. The Biochemical Journal. 342: 729-35. PMID 10477286 DOI: 10.1042/0264-6021:3420729  0.72
1999 Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. Proceedings of the National Academy of Sciences of the United States of America. 96: 6489-94. PMID 10339615 DOI: 10.1073/Pnas.96.11.6489  0.72
1996 Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 379: 369-74. PMID 8552196 DOI: 10.1038/379369A0  0.72
1996 Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379: 311-9. PMID 8552184 DOI: 10.1038/379311A0  0.72
1995 Slepak VZ, Artemyev NO, Zhu Y, Dumke CL, Sabacan L, Sondek J, Hamm HE, Bownds MD, Arshavsky VY. An effector site that stimulates G-protein GTPase in photoreceptors Journal of Biological Chemistry. 270: 14319-14324. PMID 7782290 DOI: 10.1074/Jbc.270.24.14319  0.72
1995 Shortle D, Sondek J. The emerging role of insertions and deletions in protein engineering Current Opinion in Biotechnology. 6: 387-393. PMID 7579648 DOI: 10.1016/0958-1669(95)80067-0  0.72
1994 Keefe LJ, Quirk S, Gittis A, Sondek J, Lattman EE. Accommodation of insertion mutations on the surface and in the interior of staphylococcal nuclease. Protein Science : a Publication of the Protein Society. 3: 391-401. PMID 8019410 DOI: 10.1002/Pro.5560030303  0.72
1994 Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276A0  0.72
1993 Keefe LJ, Sondek J, Shortle D, Lattman EE. The α aneurism: A structural motif revealed in an insertion mutant of staphylococcal nuclease Proceedings of the National Academy of Sciences of the United States of America. 90: 3275-3279. PMID 8475069 DOI: 10.1073/Pnas.90.8.3275  0.72
1992 Sondek J, Shortle D. Structural and energetic differences between insertions and substitutions in staphylococcal nuclease Proteins: Structure, Function and Genetics. 13: 132-140. PMID 1620695 DOI: 10.1002/Prot.340130206  0.72
1992 Sondek J, Shortle D. A general strategy for random insertion and substitution mutagenesis: Substoichiometric coupling of trinucleotide phosphoramidites Proceedings of the National Academy of Sciences of the United States of America. 89: 3581-3585. PMID 1565654 DOI: 10.1073/Pnas.89.8.3581  0.72
1990 Sondek J, Shortle D. Accomodation of single amino acid insertions by the native state of staphylococcal nuclease Proteins: Structure, Function and Genetics. 7: 299-305. PMID 2381904 DOI: 10.1002/Prot.340070402  0.72
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