Richard C. Boucher - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Molecular Biology

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O'Neal YK, ... ... Boucher RC, et al. Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia. American Journal of Respiratory and Critical Care Medicine. PMID 33321047 DOI: 10.1164/rccm.202008-3198OC  0.4
2020 Xu J, Livraghi-Butrico A, Hou X, Rajagopalan C, Zhang J, Song J, Jiang H, Wei HG, Wang H, Bouhamdan M, Ruan J, Yang D, Qiu Y, Youming X, Barrett RP, ... ... Boucher RC, et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. Jci Insight. PMID 33232302 DOI: 10.1172/jci.insight.139813  0.36
2020 Kim V, Jeong S, Zhao H, Kesimer M, Boucher RC, Wells JM, Christenson SA, Han MK, Dransfield M, Paine R, Cooper CB, Barjaktarevic I, Bowler R, Curtis JL, Kaner RJ, et al. Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects. Scientific Reports. 10: 20133. PMID 33208859 DOI: 10.1038/s41598-020-77229-1  0.36
2020 Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Christenson SA, Comellas A, Cooper CB, Couper D, et al. Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. American Journal of Respiratory and Critical Care Medicine. PMID 33180550 DOI: 10.1164/rccm.202006-2248OC  0.36
2020 Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, ... ... Boucher RC, et al. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell. PMID 32526206 DOI: 10.1016/J.Cell.2020.05.042  0.36
2020 Rao W, Wang S, Duleba M, Niroula S, Goller K, Xie J, Mahalingam R, Neupane R, Liew AA, Vincent M, Okuda K, O'Neal WK, Boucher RC, Dickey BF, Wechsler ME, et al. Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis. Cell. PMID 32298651 DOI: 10.1016/J.Cell.2020.03.047  0.36
2020 McCarron A, Cmielewski P, Reyne N, McIntyre C, Finnie J, Craig F, Rout-Pitt N, Delhove J, Schjenken JE, Chan HY, Boog B, Knight E, Gilmore RC, O'Neal WK, Boucher RC, et al. Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology. PMID 32084371 DOI: 10.1016/J.Ajpath.2020.01.009  0.36
2019 van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson SH, Stephan H, Boucher RC, Lazarowski ER. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 31800264 DOI: 10.1152/Ajplung.00449.2019  0.36
2019 Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, ... ... Boucher RC, et al. IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis. The Journal of Clinical Investigation. PMID 31524632 DOI: 10.1172/Jci125669  0.6
2019 Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, ... ... Boucher RC, et al. XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia. American Journal of Respiratory and Critical Care Medicine. PMID 30973754 DOI: 10.1164/Rccm.201810-1972Oc  0.36
2019 Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC. Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum. Copd. 1-9. PMID 30712400 DOI: 10.1080/15412555.2019.1566892  0.36
2018 Christenson SA, van den Berge M, Faiz A, Imkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, et al. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. The Journal of Clinical Investigation. PMID 30383540 DOI: 10.1172/Jci121087  0.36
2018 Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, ... ... Boucher RC, et al. Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways. American Journal of Respiratory and Critical Care Medicine. PMID 30352166 DOI: 10.1164/Rccm.201804-0734Oc  0.36
2018 Ehre C, Rushton ZL, Wang B, Hothem LN, Morrison CB, Fontana NC, Markovetz MR, Delion MF, Kato T, Villalon D, Thelin WR, Esther CR, Hill DB, Grubb BR, Livraghi-Butrico A, ... ... Boucher RC, et al. An Improved Inhaled Mucolytic to Treat Airway Muco-Obstructive Diseases. American Journal of Respiratory and Critical Care Medicine. PMID 30212240 DOI: 10.1164/Rccm.201802-0245Oc  0.36
2018 Saini Y, Lewis BW, Yu D, Dang H, Livraghi-Butrico A, Del Piero F, O'Neal WK, Boucher RC. Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis. Physiological Reports. 6: e13677. PMID 29667749 DOI: 10.14814/Phy2.13677  0.36
2018 Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, Livraghi-Butrico A, Boucher RC. Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naïve and Muco-obstructed Mice. American Journal of Respiratory Cell and Molecular Biology. PMID 29579396 DOI: 10.1165/Rcmb.2017-0127Oc  0.36
2018 Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, et al. Association between acute respiratory disease events and thepromoter polymorphism in smokers. Thorax. PMID 29440587 DOI: 10.1136/Thoraxjnl-2017-211208  0.36
2017 Livraghi-Butrico A, Wilkinson KJ, Volmer AS, Gilmore RC, Rogers TD, Caldwell RA, Burns KA, Esther CR, Mall MA, Boucher RC, O'Neal WK, Grubb BR. Lung disease phenotypes caused by over-expression of combinations of alpha, beta, and gamma subunits of the epithelial sodium channel in mouse airways. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00382.2017. PMID 29074490 DOI: 10.1152/Ajplung.00382.2017  0.36
2017 Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, ... ... Boucher RC, et al. Airway Mucin Concentration as a Marker of Chronic Bronchitis. The New England Journal of Medicine. 377: 911-922. PMID 28877023 DOI: 10.1056/Nejmoa1701632  0.36
2017 Donoghue LJ, Livraghi-Butrico A, McFadden KM, Thomas JM, Chen G, Grubb BR, O'Neal WK, Boucher RC, Kelada SNP. Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics. PMID 28851744 DOI: 10.1534/Genetics.117.300211  0.36
2017 Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunology. 10: 829. PMID 28435155 DOI: 10.1038/mi.2017.29  0.36
2016 Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunology. PMID 27435107 DOI: 10.1038/Mi.2016.63  0.36
2015 Lubamba BA, Jones LC, O'Neal WK, Boucher RC, Ribeiro CM. X-Box Binding Protein 1 Modulates Innate Immune Responses of Cystic Fibrosis Alveolar Macrophages. American Journal of Respiratory and Critical Care Medicine. PMID 26331676 DOI: 10.1164/Rccm.201504-0657Oc  0.6
2015 Saini Y, Wilkinson KJ, Terrell KA, Burns KA, Livraghi-Butrico A, Doerschuk CM, O'Neal WK, Boucher RC. Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses. American Journal of Respiratory Cell and Molecular Biology. PMID 26121027 DOI: 10.1165/Rcmb.2014-0111Oc  0.36
2015 Bennett WD, Wu J, Fuller F, Balcazar JR, Zeman KL, Duckworth H, Donn KH, O'Riordan TG, Boucher RC, Donaldson SH. Duration of action of hypertonic saline on mucociliary clearance in the normal lung. Journal of Applied Physiology (Bethesda, Md. : 1985). 118: 1483-90. PMID 25911685 DOI: 10.1152/Japplphysiol.00404.2014  0.8
2015 Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, ... ... Boucher RC, et al. The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis. American Journal of Respiratory and Critical Care Medicine. 192: 182-90. PMID 25909230 DOI: 10.1164/Rccm.201412-2230Oc  0.8
2015 Esther CR, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC. Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis. Chest. PMID 25611918 DOI: 10.1378/Chest.14-1800  0.8
2015 Ghosh A, Boucher RC, Tarran R. Airway hydration and COPD Cellular and Molecular Life Sciences. DOI: 10.1007/s00018-015-1946-7  0.8
2014 Saini Y, Dang H, Livraghi-Butrico A, Kelly EJ, Jones LC, O'Neal WK, Boucher RC. Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration. Bmc Genomics. 15: 726. PMID 25204199 DOI: 10.1186/1471-2164-15-726  0.8
2014 Schwab U, Abdullah LH, Perlmutt OS, Albert D, Davis CW, Arnold RR, Yankaskas JR, Gilligan P, Neubauer H, Randell SH, Boucher RC. Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus. Infection and Immunity. 82: 4729-45. PMID 25156735 DOI: 10.1128/Iai.01876-14  0.8
2014 Morgan KS, Donnelley M, Farrow N, Fouras A, Yagi N, Suzuki Y, Takeuchi A, Uesugi K, Boucher RC, Siu KKW, Parsons DW. In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis American Journal of Respiratory and Critical Care Medicine. 190: 469-471. PMID 25127306 DOI: 10.1164/Rccm.201405-0855Le  0.8
2014 Cholon DM, Quinney NL, Fulcher ML, Esther CR, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis. Science Translational Medicine. 6: 246ra96. PMID 25101886 DOI: 10.1126/Scitranslmed.3008680  0.8
2014 Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. The Journal of Clinical Investigation. 124: 3047-60. PMID 24892808 DOI: 10.1172/Jci73469  0.8
2014 Hill DB, Vasquez PA, Mellnik J, McKinley SA, Vose A, Mu F, Henderson AG, Donaldson SH, Alexis NE, Boucher RC, Forest MG. A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. Plos One. 9: e87681. PMID 24558372 DOI: 10.1371/Journal.Pone.0087681  0.8
2014 Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, ... ... Boucher RC, et al. Muc5b is required for airway defence. Nature. 505: 412-6. PMID 24317696 DOI: 10.1038/Nature12807  0.8
2014 Bove PF, Dang H, Cheluvaraju C, Jones LC, Liu X, O'Neal WK, Randell SH, Schlegel R, Boucher RC. Breaking the in vitro alveolar type II cell proliferation barrier while retaining ion transport properties. American Journal of Respiratory Cell and Molecular Biology. 50: 767-76. PMID 24191670 DOI: 10.1165/Rcmb.2013-0071Oc  0.8
2014 Esther CR, Boucher RC, Johnson MR, Ansede JH, Donn KH, O'Riordan TG, Ghio AJ, Hirsh AJ. Airway drug pharmacokinetics via analysis of exhaled breath condensate. Pulmonary Pharmacology & Therapeutics. 27: 76-82. PMID 23932897 DOI: 10.1016/J.Pupt.2013.07.009  0.8
2014 O'Riordan TG, Donn KH, Hodsman P, Ansede JH, Newcomb T, Lewis SA, Flitter WD, White VS, Johnson MR, Montgomery AB, Warnock DG, Boucher RC. Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 trial of GS-9411. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 27: 200-8. PMID 23905576 DOI: 10.1089/Jamp.2013.1037  0.8
2014 Donnelley M, Morgan KS, Siu KKW, Farrow NR, Stahr CS, Boucher RC, Fouras A, Parsons DW. Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo Scientific Reports. 4. DOI: 10.1038/srep03689  0.8
2013 Okada SF, Ribeiro CM, Sesma JI, Seminario-Vidal L, Abdullah LH, van Heusden C, Lazarowski ER, Boucher RC. Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways. American Journal of Respiratory Cell and Molecular Biology. 49: 814-20. PMID 23763446 DOI: 10.1165/Rcmb.2012-0493Oc  0.6
2013 Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC. Mechanosensitive ATP release maintains proper mucus hydration of airways. Science Signaling. 6: ra46. PMID 23757023 DOI: 10.1126/Scisignal.2003755  0.8
2013 Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR. Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L469-80. PMID 23377346 DOI: 10.1152/Ajplung.00150.2012  0.8
2013 Esther CR, Olsen BM, Lin FC, Fine J, Boucher RC. Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L504-9. PMID 23355385 DOI: 10.1152/Ajplung.00344.2012  0.8
2013 Tunney MM, Einarsson GG, Wei L, Drain M, Klem ER, Cardwell C, Ennis M, Boucher RC, Wolfgang MC, Elborn JS. Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation. American Journal of Respiratory and Critical Care Medicine. 187: 1118-26. PMID 23348972 DOI: 10.1164/Rccm.201210-1937Oc  0.8
2012 Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu X, Yuan H, Cheluvaraju C, Clapp PW, Boucher RC, Kamonjoh CM, Randell SH, Schlegel R. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 20035-40. PMID 23169653 DOI: 10.1073/Pnas.1213241109  0.8
2012 Fodor AA, Klem ER, Gilpin DF, Elborn JS, Boucher RC, Tunney MM, Wolfgang MC. The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations. Plos One. 7: e45001. PMID 23049765 DOI: 10.1371/Journal.Pone.0045001  0.8
2012 Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs Proceedings of the National Academy of Sciences of the United States of America. 109: 16528-16533. PMID 23012413 DOI: 10.1073/Pnas.1206552109  0.8
2012 Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science (New York, N.Y.). 337: 937-41. PMID 22923574 DOI: 10.1126/Science.1223012  0.8
2012 Yu D, Thelin WR, Randell SH, Boucher RC. Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland. Experimental Eye Research. 103: 22-32. PMID 22828047 DOI: 10.1016/J.Exer.2012.07.005  0.8
2012 Yu D, Thelin WR, Rogers TD, Jackson Stutts M, Randell SH, Grubb BR, Boucher RC. Regional differences in rat conjunctival ion transport activities American Journal of Physiology - Cell Physiology. 303: C767-C780. PMID 22814399 DOI: 10.1152/Ajpcell.00195.2012  0.8
2012 Livraghi-Butrico A, Kelly EJ, Klem ER, Dang H, Wolfgang MC, Boucher RC, Randell SH, O'Neal WK. Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunology. 5: 397-408. PMID 22419116 DOI: 10.1038/Mi.2012.17  0.8
2012 Livraghi-Butrico A, Grubb BR, Kelly EJ, Wilkinson KJ, Yang H, Geiser M, Randell SH, Boucher RC, O'Neal WK. Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction. Physiological Genomics. 44: 470-84. PMID 22395316 DOI: 10.1152/Physiolgenomics.00185.2011  0.8
2012 Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ. Significance of the microbiome in obstructive lung disease. Thorax. 67: 456-63. PMID 22318161 DOI: 10.1136/Thoraxjnl-2011-201183  0.8
2012 Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/Rccm.201111-2068Ws  0.8
2012 Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM. VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells. The Journal of Physiology. 590: 545-62. PMID 22144578 DOI: 10.1113/Jphysiol.2011.222091  0.8
2012 Grubb BR, O'Neal WK, Ostrowski LE, Kreda SM, Button B, Boucher RC. Transgenic hCFTR expression fails to correct β -ENaC mouse lung disease American Journal of Physiology - Lung Cellular and Molecular Physiology. 302: 238-247. PMID 22003093 DOI: 10.1152/Ajplung.00083.2011  0.8
2012 Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 533-45. PMID 21990373 DOI: 10.1096/Fj.11-192377  0.8
2012 Oldenburg AL, Chhetri RK, Button BM, Hill DB, Boucher RC. Dynamic imaging of in vitro human airway epithelium using optical coherence tomography Biomedical Optics, Biomed 2012. DOI: 10.1364/Biomed.2012.Btu4B.6  0.8
2011 Seminario-Vidal L, Okada SF, Sesma JI, Kreda SM, van Heusden CA, Zhu Y, Jones LC, O'Neal WK, Penuela S, Laird DW, Boucher RC, Lazarowski ER. Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. The Journal of Biological Chemistry. 286: 26277-86. PMID 21606493 DOI: 10.1074/Jbc.M111.260562  0.36
2011 Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. Sub-Cellular Biochemistry. 55: 51-74. PMID 21560044 DOI: 10.1007/978-94-007-1217-1_3  0.4
2011 Clunes MT, Boucher RC. Introduction to section I: overview of approaches to study cystic fibrosis pathophysiology. Methods in Molecular Biology (Clifton, N.J.). 742: 3-14. PMID 21547723 DOI: 10.1007/978-1-61779-120-8_1  0.8
2011 Tunney MM, Klem ER, Fodor AA, Gilpin DF, Moriarty TF, McGrath SJ, Muhlebach MS, Boucher RC, Cardwell C, Doering G, Elborn JS, Wolfgang MC. Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis. Thorax. 66: 579-84. PMID 21270069 DOI: 10.1136/Thx.2010.137281  0.8
2011 Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC, Bruce KD. Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers. Journal of Clinical Microbiology. 49: 281-91. PMID 21068277 DOI: 10.1128/Jcm.01650-10  0.8
2011 Okada SF, Zhang L, Kreda SM, Abdullah LH, Davis CW, Pickles RJ, Lazarowski ER, Boucher RC. Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium. American Journal of Respiratory Cell and Molecular Biology. 45: 253-60. PMID 20935191 DOI: 10.1165/Rcmb.2010-0253Oc  0.36
2010 Ribeiro CM, Boucher RC. Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses. Proceedings of the American Thoracic Society. 7: 387-94. PMID 21030518 DOI: 10.1513/pats.201001-017AW  0.6
2010 Bove PF, Grubb BR, Okada SF, Ribeiro CMP, Rogers TD, Randell SH, O'Neal WK, Boucher RC. Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling Journal of Biological Chemistry. 285: 34939-34949. PMID 20801871 DOI: 10.1074/Jbc.M110.162933  0.8
2010 Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. The Journal of Biological Chemistry. 285: 26945-55. PMID 20566636 DOI: 10.1074/Jbc.M110.151803  0.8
2010 Goralski JL, Boucher RC, Button B. Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Current Opinion in Pharmacology. 10: 294-9. PMID 20439165 DOI: 10.1016/J.Coph.2010.04.003  0.8
2010 Kreda SM, Seminario-Vidal L, van Heusden CA, O'Neal W, Jones L, Boucher RC, Lazarowski ER. Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides. The Journal of Physiology. 588: 2255-67. PMID 20421285 DOI: 10.1113/Jphysiol.2009.186643  0.36
2009 Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ. CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. Plos Biology. 7: e1000155. PMID 19621064 DOI: 10.1371/Journal.Pbio.1000155  0.8
2009 Ribeiro CM, Hurd H, Wu Y, Martino ME, Jones L, Brighton B, Boucher RC, O'Neal WK. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. Plos One. 4: e5806. PMID 19503797 DOI: 10.1371/Journal.Pone.0005806  0.8
2009 Rock JR, O'Neal WK, Gabriel SE, Randell SH, Harfe BD, Boucher RC, Grubb BR. Transmembrane protein 16A (TMEM16A) is a Ca2+ -regulated Cl- secretory channel in mouse airways Journal of Biological Chemistry. 284: 14875-14880. PMID 19363029 DOI: 10.1074/Jbc.C109.000869  0.8
2009 Grubb BR, Rogers TD, Boucher RC, Ostrowski LE. Ion transport across CF and normal murine olfactory and ciliated epithelium American Journal of Physiology - Cell Physiology. 296: C1301-C1309. PMID 19321738 DOI: 10.1152/Ajpcell.00578.2008  0.8
2009 Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH. Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment. Journal of Immunology (Baltimore, Md. : 1950). 182: 4357-67. PMID 19299736 DOI: 10.4049/Jimmunol.0802557  0.8
2008 Thelin WR, Brennan MT, Lockhart PB, Singh ML, Fox PC, Papas AS, Boucher RC. The oral mucosa as a therapeutic target for xerostomia. Oral Diseases. 14: 683-9. PMID 19193197 DOI: 10.1111/J.1601-0825.2008.01486.X  0.8
2008 Esther CR, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC. Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Biochemistry. 47: 9269-78. PMID 18693752 DOI: 10.1021/Bi800855K  0.8
2008 Zuo P, Picher M, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis. The Journal of Biological Chemistry. 283: 26805-19. PMID 18662982 DOI: 10.1074/Jbc.M801516200  0.4
2008 Clunes MT, Boucher RC. Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis Current Opinion in Pharmacology. 8: 292-299. PMID 18468487 DOI: 10.1016/J.Coph.2008.04.006  0.8
2008 Esther CR, Alexis NE, Clas ML, Lazarowski ER, Donaldson SH, Ribeiro CM, Moore CG, Davis SD, Boucher RC. Extracellular purines are biomarkers of neutrophilic airway inflammation. The European Respiratory Journal. 31: 949-56. PMID 18256064 DOI: 10.1183/09031936.00089807  0.8
2008 Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. The Journal of Pharmacology and Experimental Therapeutics. 325: 77-88. PMID 18218832 DOI: 10.1124/Jpet.107.130443  0.8
2008 Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, Boucher RC. Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice. American Journal of Respiratory and Critical Care Medicine. 177: 730-42. PMID 18079494 DOI: 10.1164/Rccm.200708-1233Oc  0.36
2008 Livraghi A, Mall M, Paradiso AM, Boucher RC, Ribeiro CM. Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment. American Journal of Respiratory Cell and Molecular Biology. 38: 423-34. PMID 17989361 DOI: 10.1165/Rcmb.2007-0177Oc  0.6
2008 Esther CK, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC. Similarities between UDP-glucose and adenine nucleotide release in yeast: Involvement of the secretory pathway (Biochemistry (2008) 47, 35, (9269-9278)) Biochemistry. 47: 11693. DOI: 10.1021/Bi8018477  0.8
2008 Clunes MT, Bove PF, Boucher RC. Integration of Epithelial Ion Transport Activities into Airway Surface Liquid Volume and Ion Composition Regulation The Pulmonary Epithelium in Health and Disease. 89-110. DOI: 10.1002/9780470727010.ch5  0.8
2007 Hirsh AJ, Stonebraker JR, van Heusden CA, Lazarowski ER, Boucher RC, Picher M. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. Biochemistry. 46: 10373-83. PMID 17696452 DOI: 10.1021/Bi7009647  0.4
2007 Kreda SM, Okada SF, van Heusden CA, O'Neal W, Gabriel S, Abdullah L, Davis CW, Boucher RC, Lazarowski ER. Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells. The Journal of Physiology. 584: 245-59. PMID 17656429 DOI: 10.1113/jphysiol.2007.139840  0.36
2007 Thelin WR, Boucher RC. The epithelium as a target for therapy in cystic fibrosis. Current Opinion in Pharmacology. 7: 290-5. PMID 17475561 DOI: 10.1016/J.Coph.2007.01.004  0.8
2007 Button B, Picher M, Boucher RC. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. The Journal of Physiology. 580: 577-92. PMID 17317749 DOI: 10.1113/Jphysiol.2006.126086  0.4
2007 Winters SL, Davis CW, Boucher RC. Mechanosensitivity of mouse tracheal ciliary beat frequency: roles for Ca2+, purinergic signaling, tonicity, and viscosity. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L614-24. PMID 16963528 DOI: 10.1152/Ajplung.00288.2005  0.8
2007 Clunes MT, Boucher RC. Cystic fibrosis: the mechanisms of pathogenesis of an inherited lung disorder Drug Discovery Today: Disease Mechanisms. 4: 63-72. DOI: 10.1016/j.ddmec.2007.09.001  0.8
2006 Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM, Superfine R, Rubinstein M, Iglewski BH, Boucher RC. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proceedings of the National Academy of Sciences of the United States of America. 103: 18131-6. PMID 17116883 DOI: 10.1073/Pnas.0606428103  0.8
2006 Muhlebach MS, MacDonald SL, Button B, Hubbard JJ, Turner ML, Boucher RC, Kilpatrick DC. Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent. Clinical and Experimental Immunology. 145: 302-7. PMID 16879250 DOI: 10.1111/J.1365-2249.2006.03151.X  0.8
2006 Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC. Physiological regulation of ATP release at the apical surface of human airway epithelia. The Journal of Biological Chemistry. 281: 22992-3002. PMID 16754672 DOI: 10.1074/Jbc.M603019200  0.8
2006 Douillet CD, Robinson WP, Milano PM, Boucher RC, Rich PB. Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathways. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L734-46. PMID 16632518 DOI: 10.1152/Ajplung.00389.2005  0.8
2006 Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. The Journal of Clinical Investigation. 116: 436-46. PMID 16440061 DOI: 10.1172/Jci24684  0.8
2006 Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. The New England Journal of Medicine. 354: 241-50. PMID 16421365 DOI: 10.1056/Nejmoa043891  0.8
2006 Perez-Vilar J, Mabolo R, McVaugh CT, Bertozzi CR, Boucher RC. Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion. The Journal of Biological Chemistry. 281: 4844-55. PMID 16377632 DOI: 10.1074/Jbc.M510520200  0.8
2006 Robinson WP, Douillet CD, Milano PM, Boucher RC, Patterson C, Rich PB. ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1988-96. PMID 16361361 DOI: 10.1152/Ajpheart.00344.2005  0.8
2006 Grubb BR, Gabriel SE, Mengos A, Gentzsch M, Randell SH, Van Heeckeren AM, Knowles MR, Drumm ML, Riordan JR, Boucher RC. SERCA pump inhibitors do not correct biosynthetic arrest of ΔF508 CFTR in cystic fibrosis American Journal of Respiratory Cell and Molecular Biology. 34: 355-363. PMID 16284361 DOI: 10.1165/Rcmb.2005-0286Oc  0.8
2006 Grubb BR, Rogers TD, Diggs PC, Boucher RC, Ostrowski LE. Culture of murine nasal epithelia: model for cystic fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L270-7. PMID 16155086 DOI: 10.1152/Ajplung.00249.2005  0.8
2005 Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. The Journal of Biological Chemistry. 280: 35751-9. PMID 16087672 DOI: 10.1074/Jbc.M505832200  0.6
2005 Matsui H, Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC. Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces Journal of Immunology. 175: 1090-1099. PMID 16002710 DOI: 10.4049/Jimmunol.175.2.1090  0.8
2005 Douillet CD, Suy S, Zarzaur BL, Robinson WP, Milano PM, Boucher RC, Rich PB. Measurement of free and bound fractions of extracellular ATP in biological solutions using bioluminescence. Luminescence : the Journal of Biological and Chemical Luminescence. 20: 435-41. PMID 15966056 DOI: 10.1002/Bio.869  0.8
2005 Highsmith WE, Friedman KJ, Burch LH, Spock A, Silverman LM, Boucher RC, Knowles MR. A CFTR mutation (D1152H) in a family with mild lung disease and normal sweat chlorides. Clinical Genetics. 68: 88-90. PMID 15952991 DOI: 10.1111/J.1399-0004.2005.00459.X  0.8
2005 Perez-Vilar J, Ribeiro CM, Salmon WC, Mabolo R, Boucher RC. Mucin granules are in close contact with tubular elements of the endoplasmic reticulum. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1305-9. PMID 15923355 DOI: 10.1369/Jhc.5B6713.2005  0.8
2005 Ribeiro CM, Paradiso AM, Schwab U, Perez-Vilar J, Jones L, O'neal W, Boucher RC. Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia. The Journal of Biological Chemistry. 280: 17798-806. PMID 15746099 DOI: 10.1074/Jbc.M410618200  0.6
2005 Perez-Vilar J, Olsen JC, Chua M, Boucher RC. pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. The Journal of Biological Chemistry. 280: 16868-81. PMID 15718243 DOI: 10.1074/Jbc.M413289200  0.8
2005 Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC. Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Molecular Biology of the Cell. 16: 2154-67. PMID 15716351 DOI: 10.1091/Mbc.E04-11-1010  0.36
2005 Ribeiro CM, Paradiso AM, Carew MA, Shears SB, Boucher RC. Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia. The Journal of Biological Chemistry. 280: 10202-9. PMID 15647273 DOI: 10.1074/Jbc.M410617200  0.6
2005 Caldwell RA, Boucher RC, Stutts MJ. Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport American Journal of Physiology - Lung Cellular and Molecular Physiology. 288: L813-L819. PMID 15640288 DOI: 10.1152/Ajplung.00435.2004  0.8
2005 Douillet CD, Robinson WP, Zarzaur BL, Lazarowski ER, Boucher RC, Rich PB. Mechanical ventilation alters airway nucleotides and purinoceptors in lung and extrapulmonary organs. American Journal of Respiratory Cell and Molecular Biology. 32: 52-8. PMID 15388514 DOI: 10.1165/Rcmb.2004-0177Oc  0.8
2005 Fisher JK, Cummings JR, Desai KV, Vicci L, Wilde B, Keller K, Weigle C, Bishop G, Taylor RM, Davis CW, Boucher RC, O'Brien ET, Superfine R. Three-dimensional force microscope: A nanometric optical tracking and magnetic manipulation system for the biomedical sciences Review of Scientific Instruments. 76. DOI: 10.1063/1.1914777  0.8
2004 Stonebraker JR, Wagner D, Lefensty RW, Burns K, Gendler SJ, Bergelson JM, Boucher RC, O'Neal WK, Pickles RJ. Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection. Journal of Virology. 78: 13755-68. PMID 15564484 DOI: 10.1128/Jvi.78.24.13755-13768.2004  0.8
2004 Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, Boucher RC. Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. The Journal of General Physiology. 124: 513-26. PMID 15477379 DOI: 10.1085/Jgp.200409154  0.8
2004 Lazarowski ER, Tarran R, Grubb BR, Van Heusden CA, Okada S, Boucher RC. Nucleotide release provides a mechanism for airway surface liquid homeostasis Journal of Biological Chemistry. 279: 36855-36864. PMID 15210701 DOI: 10.1074/jbc.M405367200  0.8
2004 Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice Nature Medicine. 10: 487-493. PMID 15077107 DOI: 10.1038/Nm1028  0.8
2004 Picher M, Burch LH, Boucher RC. Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis. The Journal of Biological Chemistry. 279: 20234-41. PMID 14993227 DOI: 10.1074/Jbc.M400305200  0.4
2004 Grubb BR, Jones JH, Boucher RC. Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice American Journal of Physiology - Lung Cellular and Molecular Physiology. 286: L588-L595. PMID 14633516 DOI: 10.1152/Ajplung.00302.2003  0.8
2004 Caldwell RA, Boucher RC, Stutts MJ. Serine protease activation of near-silent epithelial Na+ channels American Journal of Physiology - Cell Physiology. 286: C190-C194. PMID 12967915 DOI: 10.1152/Ajpcell.00342.2003  0.8
2003 Coakley RD, Grubb BR, Paradiso AM, Gatzy JT, Johnson LG, Kreda SM, O'Neal WK, Boucher RC. Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium. Proceedings of the National Academy of Sciences of the United States of America. 100: 16083-8. PMID 14668433 DOI: 10.1073/Pnas.2634339100  0.8
2003 Rich PB, Douillet CD, Hurd H, Boucher RC. Effect of ventilatory rate on airway cytokine levels and lung injury. The Journal of Surgical Research. 113: 139-45. PMID 12943823 DOI: 10.1016/S0022-4804(03)00195-1  0.8
2003 Rich PB, Douillet CD, Mahler SA, Husain SA, Boucher RC. Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema. The Journal of Trauma. 55: 290-7. PMID 12913640 DOI: 10.1097/01.Ta.0000078882.11919.Af  0.8
2003 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG. Role of claudin interactions in airway tight junctional permeability. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L1166-78. PMID 12909588 DOI: 10.1152/Ajplung.00182.2003  0.8
2003 Coyne CB, Ribeiro CM, Boucher RC, Johnson LG. Acute mechanism of medium chain fatty acid-induced enhancement of airway epithelial permeability. The Journal of Pharmacology and Experimental Therapeutics. 305: 440-50. PMID 12606647 DOI: 10.1124/Jpet.102.047654  0.8
2003 Picher M, Burch LH, Hirsh AJ, Spychala J, Boucher RC. Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. The Journal of Biological Chemistry. 278: 13468-79. PMID 12560324 DOI: 10.1074/Jbc.M300569200  0.8
2003 Picher M, Boucher RC. Human airway ecto-adenylate kinase. A mechanism to propagate ATP signaling on airway surfaces. The Journal of Biological Chemistry. 278: 11256-64. PMID 12551890 DOI: 10.1074/Jbc.M208071200  0.4
2003 Sood N, Bennett WD, Zeman K, Brown J, Foy C, Boucher RC, Knowles MR. Increasing concentration of inhaled saline with or without amiloride: effect on mucociliary clearance in normal subjects. American Journal of Respiratory and Critical Care Medicine. 167: 158-63. PMID 12411282 DOI: 10.1164/Rccm.200204-293Oc  0.8
2002 Yoon SS, Hennigan RF, Hilliard GM, Ochsner UA, Parvatiyar K, Kamani MC, Allen HL, DeKievit TR, Gardner PR, Schwab U, Rowe JJ, Iglewski BH, McDermott TR, Mason RP, Wozniak DJ, ... ... Boucher RC, et al. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Developmental Cell. 3: 593-603. PMID 12408810 DOI: 10.1016/S1534-5807(02)00295-2  0.8
2002 Coyne CB, Vanhook MK, Gambling TM, Carson JL, Boucher RC, Johnson LG. Regulation of airway tight junctions by proinflammatory cytokines. Molecular Biology of the Cell. 13: 3218-34. PMID 12221127 DOI: 10.1091/Mbc.E02-03-0134  0.8
2002 Tarran R, Loewen ME, Paradiso AM, Olsen JC, Gray MA, Argent BE, Boucher RC, Gabriel SE. Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances. The Journal of General Physiology. 120: 407-18. PMID 12198094 DOI: 10.1085/Jgp.20028599  0.8
2002 Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J, Abraham WM, Boucher RC. Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis. The Journal of Pharmacology and Experimental Therapeutics. 302: 871-80. PMID 12183642 DOI: 10.1124/Jpet.102.035485  0.4
2002 Grubb BR, Chadburn JL, Boucher RC. In vivo microdialysis for determination of nasal liquid ion composition American Journal of Physiology - Cell Physiology. 282: C1423-C1431. PMID 11997257 DOI: 10.1152/Ajpcell.00612.2001  0.8
2002 Zhang L, Peeples ME, Boucher RC, Collins PL, Pickles RJ. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology. Journal of Virology. 76: 5654-66. PMID 11991994 DOI: 10.1128/Jvi.76.11.5654-5666.2002  0.8
2002 Chan LN, Tsang LL, Rowlands DK, Rochelle LG, Boucher RC, Liu CQ, Chan HC. Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract Journal of Membrane Biology. 185: 165-176. PMID 11891575 DOI: 10.1007/s00232-001-0117-y  0.8
2002 Donaldson SH, Picher M, Boucher RC. Secreted and cell-associated adenylate kinase and nucleoside diphosphokinase contribute to extracellular nucleotide metabolism on human airway surfaces. American Journal of Respiratory Cell and Molecular Biology. 26: 209-15. PMID 11804872 DOI: 10.1165/Ajrcmb.26.2.4650  0.4
2002 Caldwell RA, Grubb BR, Tarran R, Boucher RC, Knowles MR, Barker PM. In vivo airway surface liquid Cl- analysis with solid-state electrodes. The Journal of General Physiology. 119: 3-14. PMID 11773234 DOI: 10.1085/Jgp.119.1.3  0.8
2002 Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE. Regulation of the epithelial sodium channel by serine proteases in human airways. The Journal of Biological Chemistry. 277: 8338-45. PMID 11756432 DOI: 10.1074/Jbc.M105044200  0.8
2001 Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC, Stutts MJ. Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 14120-5. PMID 11707576 DOI: 10.1073/Pnas.241318498  0.8
2001 Tarran R, Grubb BR, Parsons D, Picher M, Hirsh AJ, Davis CW, Boucher RC. The CF salt controversy: in vivo observations and therapeutic approaches. Molecular Cell. 8: 149-58. PMID 11511368 DOI: 10.1016/S1097-2765(01)00286-6  0.8
2001 Tarran R, Grubb BR, Gatzy JT, Davis CW, Boucher RC. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. The Journal of General Physiology. 118: 223-36. PMID 11479349 DOI: 10.1085/Jgp.118.2.223  0.8
2001 Grubb BR, Pace AJ, Lee E, Koller BH, Boucher RC. Alterations in airway ion transport in NKCC1-deficient mice. American Journal of Physiology. Cell Physiology. 281: C615-23. PMID 11443061 DOI: 10.1152/Ajpcell.2001.281.2.C615  0.8
2001 Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC, Gabriel SE. Expression and localization of epithelial aquaporins in the adult human lung American Journal of Respiratory Cell and Molecular Biology. 24: 224-234. PMID 11245621 DOI: 10.1165/Ajrcmb.24.3.4367  0.8
2000 Coyne CB, Kelly MM, Boucher RC, Johnson LG. Enhanced epithelial gene transfer by modulation of tight junctions with sodium caprate. American Journal of Respiratory Cell and Molecular Biology. 23: 602-9. PMID 11062138 DOI: 10.1165/Ajrcmb.23.5.4164  0.8
2000 Grubb BR, Lee E, Pace AJ, Koller BH, Boucher RC. Intestinal ion transport in NKCC1-deficient mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G707-18. PMID 11005757 DOI: 10.1152/Ajpgi.2000.279.4.G707  0.8
2000 Gabriel SE, Makhlina M, Martsen E, Thomas EJ, Lethem MI, Boucher RC. Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+ -activated Cl- conductance in the apical membrane of murine tracheal epithelial cells Journal of Biological Chemistry. 275: 35028-35033. PMID 10944530 DOI: 10.1074/Jbc.M004953200  0.8
2000 Noone PG, Hohneker KW, Zhou Z, Johnson LG, Foy C, Gipson C, Jones K, Noah TL, Leigh MW, Schwartzbach C, Efthimiou J, Pearlman R, Boucher RC, Knowles MR. Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 105-14. PMID 10933918 DOI: 10.1006/Mthe.1999.0009  0.8
2000 Picher M, Boucher RC. Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways. American Journal of Respiratory Cell and Molecular Biology. 23: 255-61. PMID 10919994 DOI: 10.1165/Ajrcmb.23.2.4088  0.4
2000 Pickles RJ, Fahrner JA, Petrella JM, Boucher RC, Bergelson JM. Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer Journal of Virology. 74: 6050-6057. PMID 10846088 DOI: 10.1128/Jvi.74.13.6050-6057.2000  0.8
2000 Johnson LG, Olsen JC, Naldini L, Boucher RC. Pseudotyped human lentiviral vector-mediated gene transfer to airway epithelia in vivo. Gene Therapy. 7: 568-74. PMID 10819571 DOI: 10.1038/Sj.Gt.3301138  0.8
2000 Huang P, Trotter K, Boucher RC, Milgram SL, Stutts MJ. PKA holoenzyme is functionally coupled to CFTR by AKAPs. American Journal of Physiology. Cell Physiology. 278: C417-22. PMID 10666038 DOI: 10.1152/Ajpcell.2000.278.2.C417  0.8
1999 Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. The Journal of Cell Biology. 147: 879-90. PMID 10562288 DOI: 10.1083/Jcb.147.4.879  0.8
1999 Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR. Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport. The Journal of Biological Chemistry. 274: 26461-8. PMID 10473606 DOI: 10.1074/Jbc.274.37.26461  0.36
1999 Homolya L, Watt WC, Lazarowski ER, Koller BH, Boucher RC. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. The Journal of Biological Chemistry. 274: 26454-60. PMID 10473605 DOI: 10.1074/Jbc.274.37.26454  0.8
1999 Noone PG, Bennett WD, Regnis JA, Zeman KL, Carson JL, King M, Boucher RC, Knowles MR. Effect of aerosolized uridine-5'-triphosphate on airway clearance with cough in patients with primary ciliary dyskinesia. American Journal of Respiratory and Critical Care Medicine. 160: 144-9. PMID 10390392 DOI: 10.1164/Ajrccm.160.1.9806146  0.8
1999 Paradiso AM, Brown HA, Ye H, Harden TK, Boucher RC. Heterogeneous responses of cell Ca2+ in human airway epithelium. Experimental Lung Research. 25: 277-90. PMID 10378100 DOI: 10.1080/019021499270196  0.36
1999 Bartlett JS, Kleinschmidt J, Boucher RC, Samulski RJ. Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody. Nature Biotechnology. 17: 181-6. PMID 10052356 DOI: 10.1038/6185  0.8
1999 Noone PG, Bali D, Carson JL, Sannuti A, Gipson CL, Ostrowski LE, Bromberg PA, Boucher RC, Knowles MR. Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia American Journal of Medical Genetics. 82: 155-160. PMID 9934981 DOI: 10.1002/(Sici)1096-8628(19990115)82:2<155::Aid-Ajmg11>3.0.Co;2-T  0.8
1998 Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 95: 1005-15. PMID 9875854 DOI: 10.1016/S0092-8674(00)81724-9  0.36
1998 Parsons DW, Grubb BR, Johnson LG, Boucher RC. Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent. Human Gene Therapy. 9: 2661-72. PMID 9874264 DOI: 10.1089/Hum.1998.9.18-2661  0.8
1998 Johnson LG, Mewshaw JP, Ni H, Friedmann T, Boucher RC, Olsen JC. Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector. Journal of Virology. 72: 8861-72. PMID 9765431 DOI: 10.1128/Jvi.72.11.8861-8872.1998  0.8
1998 Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, Boucher RC, Stutts MJ, Milgram SL. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. The Journal of Biological Chemistry. 273: 19797-801. PMID 9677412 DOI: 10.1074/Jbc.273.31.19797  0.8
1998 Pickles RJ, McCarty D, Matsui H, Hart PJ, Randell SH, Boucher RC. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer Journal of Virology. 72: 6014-6023. PMID 9621064 DOI: 10.1128/Jvi.72.7.6014-6023.1998  0.8
1998 Hofmann T, Stutts MJ, Ziersch A, Ruckes C, Weber WM, Knowles MR, Lindemann H, Boucher RC. Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis American Journal of Respiratory and Critical Care Medicine. 157: 1844-1849. PMID 9620916 DOI: 10.1164/Ajrccm.157.6.9709043  0.8
1998 Watt WC, Lazarowski ER, Boucher RC. Cystic fibrosis transmembrane regulator-independent release of ATP. Its implications for the regulation of P2Y2 receptors in airway epithelia. The Journal of Biological Chemistry. 273: 14053-8. PMID 9593757 DOI: 10.1074/Jbc.273.22.14053  0.8
1998 Batra RK, Olsen JC, Pickles RJ, Hoganson DK, Boucher RC. Transduction of non-small cell lung cancer cells by adenoviral and retroviral vectors. American Journal of Respiratory Cell and Molecular Biology. 18: 402-10. PMID 9490658 DOI: 10.1165/Ajrcmb.18.3.2784  0.8
1998 Knowles MR, Noone PG, Hohneker K, Johnson LG, Boucher RC, Efthimiou J, Crawford C, Brown R, Schwartzbach C, Pearlman R. A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis. Human Gene Therapy. 9: 249-69. PMID 9472784 DOI: 10.1089/Hum.1998.9.2-249  0.8
1997 Knowles MR, Robinson JM, Wood RE, Pue CA, Mentz WM, Wager GC, Gatzy JT, Boucher RC. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. The Journal of Clinical Investigation. 100: 2588-95. PMID 9366574 DOI: 10.1172/Jci119802  0.36
1997 Lazarowski ER, Paradiso AM, Watt WC, Harden TK, Boucher RC. UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 2599-603. PMID 9122241 DOI: 10.1073/Pnas.94.6.2599  0.8
1997 Batra RK, Olsen JC, Hoganson DK, Caterson B, Boucher RC. Retroviral gene transfer is inhibited by chondroitin sulfate proteoglycans/glycosaminoglycans in malignant pleural effusions. The Journal of Biological Chemistry. 272: 11736-43. PMID 9115227 DOI: 10.1074/Jbc.272.18.11736  0.8
1997 Highsmith WE, Burch LH, Zhou Z, Olsen JC, Strong TV, Smith T, Friedman KJ, Silverman LM, Boucher RC, Collins FS, Knowles MR. Identification of a splice site mutation (2789 +5 G > A) associated with small amounts of normal CFTR mRNA and mild cystic fibrosis. Human Mutation. 9: 332-8. PMID 9101293 DOI: 10.1002/(Sici)1098-1004(1997)9:4<332::Aid-Humu5>3.0.Co;2-7  0.8
1997 Piedimonte G, Pickles RJ, Lehmann JR, McCarty D, Costa DL, Boucher RC. Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation. American Journal of Respiratory Cell and Molecular Biology. 16: 250-8. PMID 9070609 DOI: 10.1165/Ajrcmb.16.3.9070609  0.8
1997 Farman N, Talbot CR, Boucher R, Fay M, Canessa C, Rossier B, Bonvalet JP. Noncoordinated expression of alpha-, beta-, and gamma-subunit mRNAs of epithelial Na+ channel along rat respiratory tract. The American Journal of Physiology. 272: C131-41. PMID 9038819 DOI: 10.1152/ajpcell.1997.272.1.C131  0.8
1997 Matsui H, Johnson LG, Randell SH, Boucher RC. Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells. The Journal of Biological Chemistry. 272: 1117-26. PMID 8995411 DOI: 10.1074/Jbc.272.2.1117  0.8
1996 Johnson LG, Pickles RJ, Boyles SE, Morris JC, Ye H, Zhou Z, Olsen JC, Boucher RC. In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia. Human Gene Therapy. 7: 51-9. PMID 8825868 DOI: 10.1089/Hum.1996.7.1-51  0.8
1996 Lazarowski ER, Watt WC, Stutts MJ, Brown HA, Boucher RC, Harden TK. Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. British Journal of Pharmacology. 117: 203-9. PMID 8825364 DOI: 10.1111/J.1476-5381.1996.Tb15175.X  0.8
1996 Olivier KN, Bennett WD, Hohneker KW, Zeman KL, Edwards LJ, Boucher RC, Knowles MR. Acute safety and effects on mucociliary clearance of aerosolized uridine 5'-triphosphate +/- amiloride in normal human adults. American Journal of Respiratory and Critical Care Medicine. 154: 217-23. PMID 8680683 DOI: 10.1164/Ajrccm.154.1.8680683  0.8
1996 Bennett WD, Olivier KN, Zeman KL, Hohneker KW, Boucher RC, Knowles MR. Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 153: 1796-801. PMID 8665037 DOI: 10.1164/Ajrccm.153.6.8665037  0.8
1996 Noah TL, Wortman IA, Hu PC, Leigh MW, Boucher RC. Cytokine production by cultured human bronchial epithelial cells infected with a replication-deficient adenoviral gene transfer vector or wild-type adenovirus type 5. American Journal of Respiratory Cell and Molecular Biology. 14: 417-24. PMID 8624246 DOI: 10.1165/Ajrcmb.14.5.8624246  0.8
1995 Lazarowski ER, Watt WC, Stutts MJ, Boucher RC, Harden TK. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. British Journal of Pharmacology. 116: 1619-27. PMID 8564228 DOI: 10.1111/J.1476-5381.1995.Tb16382.X  0.8
1995 Knowles MR, Olivier KN, Hohneker KW, Robinson J, Bennett WD, Boucher RC. Pharmacologic treatment of abnormal ion transport in the airway epithelium in cystic fibrosis. Chest. 107: 71S-76S. PMID 7842817 DOI: 10.1378/Chest.107.2_Supplement.71S  0.8
1995 Leigh MW, Kylander JE, Yankaskas JR, Boucher RC. Cell proliferation in bronchial epithelium and submucosal glands of cystic fibrosis patients. American Journal of Respiratory Cell and Molecular Biology. 12: 605-12. PMID 7766425 DOI: 10.1165/Ajrcmb.12.6.7766425  0.8
1995 Burch LH, Talbot CR, Knowles MR, Canessa CM, Rossier BC, Boucher RC. Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways. The American Journal of Physiology. 269: C511-8. PMID 7653534 DOI: 10.1152/Ajpcell.1995.269.2.C511  0.8
1995 Geary CA, Davis CW, Paradiso AM, Boucher RC. Role of CNP in human airways: cGMP-mediated stimulation of ciliary beat frequency. The American Journal of Physiology. 268: L1021-8. PMID 7611424 DOI: 10.1152/Ajplung.1995.268.6.L1021  0.36
1995 Teramoto S, Johnson LG, Huang W, Leigh MW, Boucher RC. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Human Gene Therapy. 6: 1045-53. PMID 7578417 DOI: 10.1089/Hum.1995.6.8-1045  0.8
1995 Paradiso AM, Mason SJ, Lazarowski ER, Boucher RC. Membrane-restricted regulation of Ca2+ release and influx in polarized epithelia. Nature. 377: 643-6. PMID 7566178 DOI: 10.1038/377643A0  0.36
1995 Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science (New York, N.Y.). 269: 847-50. PMID 7543698 DOI: 10.1126/Science.7543698  0.8
1995 Johnson LG, Boyles SE, Wilson J, Boucher RC. Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. The Journal of Clinical Investigation. 95: 1377-82. PMID 7533790 DOI: 10.1172/Jci117789  0.8
1995 Mohapatra NK, Cheng PW, Parker JC, Paradiso AM, Yankaskas JR, Boucher RC, Boat TF. Alteration of sulfation of glycoconjugates, but not sulfate transport and intracellular inorganic sulfate content in cystic fibrosis airway epithelial cells. Pediatric Research. 38: 42-8. PMID 7478795 DOI: 10.1203/00006450-199507000-00008  0.8
1994 Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proceedings of the National Academy of Sciences of the United States of America. 91: 3275-9. PMID 8159738 DOI: 10.1073/Pnas.91.8.3275  0.8
1994 Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proceedings of the National Academy of Sciences of the United States of America. 91: 13067. PMID 7809171 DOI: 10.1073/Pnas.91.26.13067  0.8
1994 Grubb BR, Pickles RJ, Ye H, Yankaskas JR, Vick RN, Engelhardt JF, Wilson JM, Johnson LG, Boucher RC. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature. 371: 802-6. PMID 7523956 DOI: 10.1038/371802A0  0.8
1994 Boucher RC, Knowles MR, Johnson LG, Olsen JC, Pickles R, Wilson JM, Engelhardt J, Yang Y, Grossman M. Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill. Human Gene Therapy. 5: 615-39. PMID 7519885 DOI: 10.1089/Hum.1994.5.5-615  0.8
1993 Mohapatra NK, Cheng PW, Parker JC, Paradiso AM, Yankaskas JR, Boucher RC, Boat TF. Sulfate concentrations and transport in human bronchial epithelial cells. The American Journal of Physiology. 264: C1231-7. PMID 8498482 DOI: 10.1152/Ajpcell.1993.264.5.C1231  0.8
1993 Bayle JY, Johnson LG, St George JA, Boucher RC, Olsen JC. High-efficiency gene transfer to primary monkey airway epithelial cells with retrovirus vectors using the gibbon ape leukemia virus receptor. Human Gene Therapy. 4: 161-70. PMID 8494925 DOI: 10.1089/Hum.1993.4.2-161  0.8
1993 Lethem MI, Dowell ML, Van Scott M, Yankaskas JR, Egan T, Boucher RC, Davis CW. Nucleotide regulation of goblet cells in human airway epithelial explants: normal exocytosis in cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology. 9: 315-22. PMID 8398169 DOI: 10.1165/Ajrcmb/9.3.315  0.8
1993 Johnson LG, Dickman KG, Moore KL, Mandel LJ, Boucher RC. Enhanced Na+ transport in an air-liquid interface culture system. The American Journal of Physiology. 264: L560-5. PMID 8333549 DOI: 10.1152/Ajplung.1993.264.6.L560  0.8
1993 Olsen JC, Johnson LG, Wong-Sun ML, Moore KL, Swanstrom R, Boucher RC. Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expression. Nucleic Acids Research. 21: 663-9. PMID 7680124 DOI: 10.1093/Nar/21.3.663  0.8
1992 Clarke LL, Paradiso AM, Mason SJ, Boucher RC. Effects of bradykinin on Na+ and Cl- transport in human nasal epithelium. The American Journal of Physiology. 262: C644-55. PMID 1550208 DOI: 10.1152/Ajpcell.1992.262.3.C644  0.36
1992 Curiel DT, Agarwal S, Rømer MU, Wagner E, Cotten M, Birnstiel ML, Boucher RC. Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. American Journal of Respiratory Cell and Molecular Biology. 6: 247-252. PMID 1540389 DOI: 10.1165/Ajrcmb/6.3.247  0.8
1992 Clarke LL, Burns KA, Bayle JY, Boucher RC, Van Scott MR. Sodium- and chloride-conductive pathways in cultured mouse tracheal epithelium. The American Journal of Physiology. 263: L519-25. PMID 1443155 DOI: 10.1152/Ajplung.1992.263.5.L519  0.8
1992 Clarke LL, Grubb BR, Gabriel SE, Smithies O, Koller BH, Boucher RC. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (New York, N.Y.). 257: 1125-8. PMID 1380724 DOI: 10.1126/Science.257.5073.1125  0.36
1992 Olsen JC, Johnson LG, Stutts MJ, Sarkadi B, Yankaskas JR, Swanstrom R, Boucher RC. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Human Gene Therapy. 3: 253-66. PMID 1379473 DOI: 10.1089/Hum.1992.3.3-253  0.8
1992 Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nature Genetics. 2: 240-8. PMID 1285365 DOI: 10.1038/Ng1192-240  0.8
1992 Johnson LG, Olsen JC, Sarkadi B, Moore KL, Swanstrom R, Boucher RC. Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nature Genetics. 2: 21-5. PMID 1284642 DOI: 10.1038/Ng0992-21  0.8
1991 Knowles MR, Church NL, Waltner WE, Yankaskas JR, Gilligan P, King M, Edwards LJ, Helms RW, Boucher RC. Aerosolized amiloride as treatment of cystic fibrosis lung disease: a pilot study. Advances in Experimental Medicine and Biology. 290: 119-28; discussion 1. PMID 1950741 DOI: 10.1007/978-1-4684-5934-0_14  0.8
1991 Mason SJ, Paradiso AM, Boucher RC. Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium. British Journal of Pharmacology. 103: 1649-56. PMID 1718521 DOI: 10.1111/J.1476-5381.1991.Tb09842.X  0.36
1990 Carson JL, Collier AM, Gambling TM, Knowles MR, Boucher RC. Ultrastructure of airway epithelial cell membranes among patients with cystic fibrosis. Human Pathology. 21: 640-7. PMID 2351392 DOI: 10.1016/S0046-8177(96)90011-8  0.8
1990 Retsch-Bogart GZ, Stiles AD, Moats-Staats BM, Van Scott MR, Boucher RC, D'Ercole AJ. Canine tracheal epithelial cells express the type 1 insulin-like growth factor receptor and proliferate in response to insulin-like growth factor I. American Journal of Respiratory Cell and Molecular Biology. 3: 227-34. PMID 2167699 DOI: 10.1165/Ajrcmb/3.3.227  0.8
1990 Knowles MR, Church NL, Waltner WE, Yankaskas JR, Gilligan P, King M, Edwards LJ, Helms RW, Boucher RC. A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. The New England Journal of Medicine. 322: 1189-94. PMID 2157983 DOI: 10.1056/Nejm199004263221704  0.8
1989 Johnson LG, Cheng PW, Boucher RC. Albumin absorption by canine bronchial epithelium. Journal of Applied Physiology (Bethesda, Md. : 1985). 66: 2772-7. PMID 2745340 DOI: 10.1152/Jappl.1989.66.6.2772  0.8
1989 Cheng PW, Boat TF, Cranfill K, Yankaskas JR, Boucher RC. Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis. The Journal of Clinical Investigation. 84: 68-72. PMID 2738159 DOI: 10.1172/Jci114171  0.8
1988 Gowen CW, Lawson EE, Gingras J, Boucher RC, Gatzy JT, Knowles MR. Electrical potential difference and ion transport across nasal epithelium of term neonates: correlation with mode of delivery, transient tachypnea of the newborn, and respiratory rate. The Journal of Pediatrics. 113: 121-7. PMID 3385520 DOI: 10.1016/S0022-3476(88)80545-6  0.36
1988 Carson JL, Collier AM, Gambling TM, Leigh MW, Boucher RC, Hu SC, Boat TF. Development, organization, and function of tight junctional complexes in the tracheal epithelium of infant ferrets. The American Review of Respiratory Disease. 138: 666-74. PMID 3202419 DOI: 10.1164/Ajrccm/138.3.666  0.8
1988 Van Scott MR, Lee NP, Yankaskas JR, Boucher RC. Effect of hormones on growth and function of cultured canine tracheal epithelial cells. The American Journal of Physiology. 255: C237-45. PMID 3044136 DOI: 10.1152/Ajpcell.1988.255.2.C237  0.8
1988 Berschneider HM, Knowles MR, Azizkhan RG, Boucher RC, Tobey NA, Orlando RC, Powell DW. Altered intestinal chloride transport in cystic fibrosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2625-9. PMID 2838365  0.8
1987 Boucher RC, James MK, Friedman M, Fullton J, Pimmel R, Gatzy JT. Acute cardiovascular and pulmonary effects of intravenous and aerosolized amiloride in the dog Toxicology and Applied Pharmacology. 87: 264-275. PMID 3824385 DOI: 10.1016/0041-008X(87)90288-2  0.8
1987 Waltner WE, Boucher RC, Gatzy JT, Knowles MR. Pharmacotherapy of airway disease in cystic fibrosis Trends in Pharmacological Sciences. 8: 316-320. DOI: 10.1016/0165-6147(87)90127-1  0.8
1986 Gowen CW, Lawson EE, Gingras-Leatherman J, Gatzy JT, Boucher RC, Knowles MR. Increased nasal potential difference and amiloride sensitivity in neonates with cystic fibrosis. The Journal of Pediatrics. 108: 517-21. PMID 3958823 DOI: 10.1016/S0022-3476(86)80825-3  0.36
1985 Carson JL, Collier AM, Knowles MR, Boucher RC. Ultrastructural characterization of epithelial cell membranes in normal human conducting airway epithelium: A freeze-fracture study. The American Journal of Anatomy. 173: 257-68. PMID 20726125 DOI: 10.1002/Aja.1001730403  0.8
1983 Jarnigan F, Davis JD, Bromberg PA, Gatzy JT, Boucher RC. Bioelectric properties and ion transport of excised rabbit trachea. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 55: 1884-92. PMID 6319342 DOI: 10.1152/Jappl.1983.55.6.1884  0.36
1983 Knowles MR, Stutts MJ, Spock A, Fischer N, Gatzy JT, Boucher RC. Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science (New York, N.Y.). 221: 1067-70. PMID 6308769 DOI: 10.1126/Science.6308769  0.8
1981 Knowles MR, Carson JL, Collier AM, Gatzy JT, Boucher RC. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. The American Review of Respiratory Disease. 124: 484-90. PMID 7294508 DOI: 10.1164/Arrd.1981.124.4.484  0.8
1981 Carson JL, Collier AM, Knowles MR, Boucher RC, Rose JG. Morphometric aspects of ciliary distribution and ciliogenesis in human nasal epithelium. Proceedings of the National Academy of Sciences of the United States of America. 78: 6996-9. PMID 6947271 DOI: 10.1073/Pnas.78.11.6996  0.8
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