Richard C. Boucher - Publications

University of North Carolina, Chapel Hill, Chapel Hill, NC 
Molecular Biology

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McCarron A, Cmielewski P, Reyne N, McIntyre C, Finnie J, Craig F, Rout-Pitt N, Delhove J, Schjenken JE, Chan HY, Boog B, Knight E, Gilmore RC, O'Neal WK, Boucher RC, et al. Phenotypic characterization and comparison of Phe508del and cystic fibrosis transmembrane conductance regulator (CFTR) knockout rat models of cystic fibrosis generated by CRISPR/Cas9 gene editing. The American Journal of Pathology. PMID 32084371 DOI: 10.1016/j.ajpath.2020.01.009  0.36
2019 van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson SH, Stephan H, Boucher RC, Lazarowski ER. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 31800264 DOI: 10.1152/ajplung.00449.2019  0.36
2019 Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, ... ... Boucher RC, et al. IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis. The Journal of Clinical Investigation. PMID 31524632 DOI: 10.1172/JCI125669  0.6
2019 Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, ... ... Boucher RC, et al. XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia. American Journal of Respiratory and Critical Care Medicine. PMID 30973754 DOI: 10.1164/rccm.201810-1972OC  0.36
2019 Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC. Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum. Copd. 1-9. PMID 30712400 DOI: 10.1080/15412555.2019.1566892  0.36
2018 Christenson SA, van den Berge M, Faiz A, Imkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, et al. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. The Journal of Clinical Investigation. PMID 30383540 DOI: 10.1172/JCI121087  0.36
2018 Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, ... ... Boucher RC, et al. Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways. American Journal of Respiratory and Critical Care Medicine. PMID 30352166 DOI: 10.1164/rccm.201804-0734OC  0.36
2018 Ehre C, Rushton ZL, Wang B, Hothem LN, Morrison CB, Fontana NC, Markovetz MR, Delion MF, Kato T, Villalon D, Thelin WR, Esther CR, Hill DB, Grubb BR, Livraghi-Butrico A, ... ... Boucher RC, et al. An Improved Inhaled Mucolytic to Treat Airway Muco-Obstructive Diseases. American Journal of Respiratory and Critical Care Medicine. PMID 30212240 DOI: 10.1164/rccm.201802-0245OC  0.36
2018 Saini Y, Lewis BW, Yu D, Dang H, Livraghi-Butrico A, Del Piero F, O'Neal WK, Boucher RC. Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis. Physiological Reports. 6: e13677. PMID 29667749 DOI: 10.14814/phy2.13677  0.36
2018 Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, Livraghi-Butrico A, Boucher RC. Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naïve and Muco-obstructed Mice. American Journal of Respiratory Cell and Molecular Biology. PMID 29579396 DOI: 10.1165/rcmb.2017-0127OC  0.36
2018 Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, et al. Association between acute respiratory disease events and thepromoter polymorphism in smokers. Thorax. PMID 29440587 DOI: 10.1136/thoraxjnl-2017-211208  0.36
2017 Livraghi-Butrico A, Wilkinson KJ, Volmer AS, Gilmore RC, Rogers TD, Caldwell RA, Burns KA, Esther CR, Mall MA, Boucher RC, O'Neal WK, Grubb BR. Lung disease phenotypes caused by over-expression of combinations of alpha, beta, and gamma subunits of the epithelial sodium channel in mouse airways. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00382.2017. PMID 29074490 DOI: 10.1152/ajplung.00382.2017  0.36
2017 Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, ... ... Boucher RC, et al. Airway Mucin Concentration as a Marker of Chronic Bronchitis. The New England Journal of Medicine. 377: 911-922. PMID 28877023 DOI: 10.1056/NEJMoa1701632  0.36
2017 Donoghue LJ, Livraghi-Butrico A, McFadden KM, Thomas JM, Chen G, Grubb BR, O'Neal WK, Boucher RC, Kelada SNP. Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics. PMID 28851744 DOI: 10.1534/genetics.117.300211  0.36
2016 Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunology. PMID 27435107 DOI: 10.1038/mi.2016.63  0.36
2015 Lubamba BA, Jones LC, O'Neal WK, Boucher RC, Ribeiro CM. X-Box Binding Protein 1 Modulates Innate Immune Responses of Cystic Fibrosis Alveolar Macrophages. American Journal of Respiratory and Critical Care Medicine. PMID 26331676 DOI: 10.1164/rccm.201504-0657OC  0.6
2015 Saini Y, Wilkinson KJ, Terrell KA, Burns KA, Livraghi-Butrico A, Doerschuk CM, O'Neal WK, Boucher RC. Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses. American Journal of Respiratory Cell and Molecular Biology. PMID 26121027 DOI: 10.1165/rcmb.2014-0111OC  0.36
2015 Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, ... ... Boucher RC, et al. The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis. American Journal of Respiratory and Critical Care Medicine. 192: 182-90. PMID 25909230 DOI: 10.1164/rccm.201412-2230OC  0.4
2015 Esther CR, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC. Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis. Chest. PMID 25611918 DOI: 10.1378/chest.14-1800  0.4
2014 Saini Y, Dang H, Livraghi-Butrico A, Kelly EJ, Jones LC, O'Neal WK, Boucher RC. Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration. Bmc Genomics. 15: 726. PMID 25204199 DOI: 10.1186/1471-2164-15-726  0.4
2014 Schwab U, Abdullah LH, Perlmutt OS, Albert D, Davis CW, Arnold RR, Yankaskas JR, Gilligan P, Neubauer H, Randell SH, Boucher RC. Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus. Infection and Immunity. 82: 4729-45. PMID 25156735 DOI: 10.1128/IAI.01876-14  0.4
2014 Morgan KS, Donnelley M, Farrow N, Fouras A, Yagi N, Suzuki Y, Takeuchi A, Uesugi K, Boucher RC, Siu KKW, Parsons DW. In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis American Journal of Respiratory and Critical Care Medicine. 190: 469-471. PMID 25127306  0.4
2014 Cholon DM, Quinney NL, Fulcher ML, Esther CR, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis. Science Translational Medicine. 6: 246ra96. PMID 25101886 DOI: 10.1126/scitranslmed.3008680  0.4
2014 Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. The Journal of Clinical Investigation. 124: 3047-60. PMID 24892808 DOI: 10.1172/JCI73469  0.4
2014 Hill DB, Vasquez PA, Mellnik J, McKinley SA, Vose A, Mu F, Henderson AG, Donaldson SH, Alexis NE, Boucher RC, Forest MG. A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. Plos One. 9: e87681. PMID 24558372 DOI: 10.1371/journal.pone.0087681  0.4
2014 Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, ... ... Boucher RC, et al. Muc5b is required for airway defence. Nature. 505: 412-6. PMID 24317696 DOI: 10.1038/nature12807  0.4
2014 Bove PF, Dang H, Cheluvaraju C, Jones LC, Liu X, O'Neal WK, Randell SH, Schlegel R, Boucher RC. Breaking the in vitro alveolar type II cell proliferation barrier while retaining ion transport properties. American Journal of Respiratory Cell and Molecular Biology. 50: 767-76. PMID 24191670 DOI: 10.1165/rcmb.2013-0071OC  0.4
2014 Esther CR, Boucher RC, Johnson MR, Ansede JH, Donn KH, O'Riordan TG, Ghio AJ, Hirsh AJ. Airway drug pharmacokinetics via analysis of exhaled breath condensate. Pulmonary Pharmacology & Therapeutics. 27: 76-82. PMID 23932897 DOI: 10.1016/j.pupt.2013.07.009  0.4
2014 O'Riordan TG, Donn KH, Hodsman P, Ansede JH, Newcomb T, Lewis SA, Flitter WD, White VS, Johnson MR, Montgomery AB, Warnock DG, Boucher RC. Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 trial of GS-9411. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 27: 200-8. PMID 23905576 DOI: 10.1089/jamp.2013.1037  0.4
2013 Okada SF, Ribeiro CM, Sesma JI, Seminario-Vidal L, Abdullah LH, van Heusden C, Lazarowski ER, Boucher RC. Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways. American Journal of Respiratory Cell and Molecular Biology. 49: 814-20. PMID 23763446 DOI: 10.1165/rcmb.2012-0493OC  0.6
2013 Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC. Mechanosensitive ATP release maintains proper mucus hydration of airways. Science Signaling. 6: ra46. PMID 23757023 DOI: 10.1126/scisignal.2003755  0.4
2013 Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR. Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L469-80. PMID 23377346 DOI: 10.1152/ajplung.00150.2012  0.4
2013 Esther CR, Olsen BM, Lin FC, Fine J, Boucher RC. Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L504-9. PMID 23355385 DOI: 10.1152/ajplung.00344.2012  0.4
2013 Tunney MM, Einarsson GG, Wei L, Drain M, Klem ER, Cardwell C, Ennis M, Boucher RC, Wolfgang MC, Elborn JS. Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation. American Journal of Respiratory and Critical Care Medicine. 187: 1118-26. PMID 23348972 DOI: 10.1164/rccm.201210-1937OC  0.4
2012 Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu X, Yuan H, Cheluvaraju C, Clapp PW, Boucher RC, Kamonjoh CM, Randell SH, Schlegel R. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 20035-40. PMID 23169653 DOI: 10.1073/pnas.1213241109  0.4
2012 Fodor AA, Klem ER, Gilpin DF, Elborn JS, Boucher RC, Tunney MM, Wolfgang MC. The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations. Plos One. 7: e45001. PMID 23049765 DOI: 10.1371/journal.pone.0045001  0.4
2012 Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs Proceedings of the National Academy of Sciences of the United States of America. 109: 16528-16533. PMID 23012413 DOI: 10.1073/pnas.1206552109  0.4
2012 Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science (New York, N.Y.). 337: 937-41. PMID 22923574 DOI: 10.1126/science.1223012  0.4
2012 Yu D, Thelin WR, Randell SH, Boucher RC. Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland. Experimental Eye Research. 103: 22-32. PMID 22828047 DOI: 10.1016/j.exer.2012.07.005  0.4
2012 Yu D, Thelin WR, Rogers TD, Jackson Stutts M, Randell SH, Grubb BR, Boucher RC. Regional differences in rat conjunctival ion transport activities American Journal of Physiology - Cell Physiology. 303: C767-C780. PMID 22814399 DOI: 10.1152/ajpcell.00195.2012  0.4
2012 Livraghi-Butrico A, Grubb BR, Kelly EJ, Wilkinson KJ, Yang H, Geiser M, Randell SH, Boucher RC, O'Neal WK. Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction. Physiological Genomics. 44: 470-84. PMID 22395316 DOI: 10.1152/physiolgenomics.00185.2011  0.4
2012 Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ. Significance of the microbiome in obstructive lung disease. Thorax. 67: 456-63. PMID 22318161 DOI: 10.1136/thoraxjnl-2011-201183  0.4
2012 Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/rccm.201111-2068WS  0.4
2012 Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM. VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells. The Journal of Physiology. 590: 545-62. PMID 22144578 DOI: 10.1113/jphysiol.2011.222091  0.4
2012 Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 533-45. PMID 21990373 DOI: 10.1096/fj.11-192377  0.4
2011 Seminario-Vidal L, Okada SF, Sesma JI, Kreda SM, van Heusden CA, Zhu Y, Jones LC, O'Neal WK, Penuela S, Laird DW, Boucher RC, Lazarowski ER. Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. The Journal of Biological Chemistry. 286: 26277-86. PMID 21606493 DOI: 10.1074/jbc.M111.260562  0.36
2011 Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. Sub-Cellular Biochemistry. 55: 51-74. PMID 21560044 DOI: 10.1007/978-94-007-1217-1_3  0.4
2011 Clunes MT, Boucher RC. Introduction to section I: overview of approaches to study cystic fibrosis pathophysiology. Methods in Molecular Biology (Clifton, N.J.). 742: 3-14. PMID 21547723 DOI: 10.1007/978-1-61779-120-8_1  0.4
2011 Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC, Bruce KD. Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers. Journal of Clinical Microbiology. 49: 281-91. PMID 21068277 DOI: 10.1128/JCM.01650-10  0.4
2011 Okada SF, Zhang L, Kreda SM, Abdullah LH, Davis CW, Pickles RJ, Lazarowski ER, Boucher RC. Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium. American Journal of Respiratory Cell and Molecular Biology. 45: 253-60. PMID 20935191 DOI: 10.1165/rcmb.2010-0253OC  0.36
2010 Ribeiro CM, Boucher RC. Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses. Proceedings of the American Thoracic Society. 7: 387-94. PMID 21030518 DOI: 10.1513/pats.201001-017AW  0.6
2010 Bove PF, Grubb BR, Okada SF, Ribeiro CMP, Rogers TD, Randell SH, O'Neal WK, Boucher RC. Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling Journal of Biological Chemistry. 285: 34939-34949. PMID 20801871 DOI: 10.1074/jbc.M110.162933  0.4
2010 Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. The Journal of Biological Chemistry. 285: 26945-55. PMID 20566636 DOI: 10.1074/jbc.M110.151803  0.4
2010 Goralski JL, Boucher RC, Button B. Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Current Opinion in Pharmacology. 10: 294-9. PMID 20439165 DOI: 10.1016/j.coph.2010.04.003  0.4
2010 Kreda SM, Seminario-Vidal L, van Heusden CA, O'Neal W, Jones L, Boucher RC, Lazarowski ER. Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides. The Journal of Physiology. 588: 2255-67. PMID 20421285 DOI: 10.1113/jphysiol.2009.186643  0.36
2009 Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ. CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. Plos Biology. 7: e1000155. PMID 19621064 DOI: 10.1371/journal.pbio.1000155  0.4
2009 Ribeiro CM, Hurd H, Wu Y, Martino ME, Jones L, Brighton B, Boucher RC, O'Neal WK. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. Plos One. 4: e5806. PMID 19503797 DOI: 10.1371/journal.pone.0005806  0.4
2009 Rock JR, O'Neal WK, Gabriel SE, Randell SH, Harfe BD, Boucher RC, Grubb BR. Transmembrane protein 16A (TMEM16A) is a Ca2+ -regulated Cl- secretory channel in mouse airways Journal of Biological Chemistry. 284: 14875-14880. PMID 19363029 DOI: 10.1074/jbc.C109.000869  0.4
2009 Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH. Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment. Journal of Immunology (Baltimore, Md. : 1950). 182: 4357-67. PMID 19299736 DOI: 10.4049/jimmunol.0802557  0.4
2008 Esther CR, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC. Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Biochemistry. 47: 9269-78. PMID 18693752 DOI: 10.1021/bi800855k  0.4
2008 Zuo P, Picher M, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis. The Journal of Biological Chemistry. 283: 26805-19. PMID 18662982 DOI: 10.1074/jbc.M801516200  0.4
2008 Clunes MT, Boucher RC. Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis Current Opinion in Pharmacology. 8: 292-299. PMID 18468487 DOI: 10.1016/j.coph.2008.04.006  0.4
2008 Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. The Journal of Pharmacology and Experimental Therapeutics. 325: 77-88. PMID 18218832 DOI: 10.1124/jpet.107.130443  0.4
2008 Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, Boucher RC. Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice. American Journal of Respiratory and Critical Care Medicine. 177: 730-42. PMID 18079494 DOI: 10.1164/rccm.200708-1233OC  0.36
2008 Livraghi A, Mall M, Paradiso AM, Boucher RC, Ribeiro CM. Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment. American Journal of Respiratory Cell and Molecular Biology. 38: 423-34. PMID 17989361 DOI: 10.1165/rcmb.2007-0177OC  0.6
2007 Hirsh AJ, Stonebraker JR, van Heusden CA, Lazarowski ER, Boucher RC, Picher M. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. Biochemistry. 46: 10373-83. PMID 17696452 DOI: 10.1021/bi7009647  0.4
2007 Kreda SM, Okada SF, van Heusden CA, O'Neal W, Gabriel S, Abdullah L, Davis CW, Boucher RC, Lazarowski ER. Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells. The Journal of Physiology. 584: 245-59. PMID 17656429 DOI: 10.1113/jphysiol.2007.139840  0.36
2007 Thelin WR, Boucher RC. The epithelium as a target for therapy in cystic fibrosis. Current Opinion in Pharmacology. 7: 290-5. PMID 17475561 DOI: 10.1016/j.coph.2007.01.004  0.4
2007 Button B, Picher M, Boucher RC. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. The Journal of Physiology. 580: 577-92. PMID 17317749 DOI: 10.1113/jphysiol.2006.126086  0.4
2007 Winters SL, Davis CW, Boucher RC. Mechanosensitivity of mouse tracheal ciliary beat frequency: roles for Ca2+, purinergic signaling, tonicity, and viscosity. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L614-24. PMID 16963528 DOI: 10.1152/ajplung.00288.2005  0.4
2006 Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM, Superfine R, Rubinstein M, Iglewski BH, Boucher RC. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proceedings of the National Academy of Sciences of the United States of America. 103: 18131-6. PMID 17116883 DOI: 10.1073/pnas.0606428103  0.4
2006 Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC. Physiological regulation of ATP release at the apical surface of human airway epithelia. The Journal of Biological Chemistry. 281: 22992-3002. PMID 16754672 DOI: 10.1074/jbc.M603019200  0.4
2006 Douillet CD, Robinson WP, Milano PM, Boucher RC, Rich PB. Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathways. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L734-46. PMID 16632518 DOI: 10.1152/ajplung.00389.2005  0.4
2006 Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. The Journal of Clinical Investigation. 116: 436-46. PMID 16440061 DOI: 10.1172/JCI24684  0.4
2006 Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. The New England Journal of Medicine. 354: 241-50. PMID 16421365 DOI: 10.1056/NEJMoa043891  0.4
2006 Perez-Vilar J, Mabolo R, McVaugh CT, Bertozzi CR, Boucher RC. Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion. The Journal of Biological Chemistry. 281: 4844-55. PMID 16377632 DOI: 10.1074/jbc.M510520200  0.4
2006 Robinson WP, Douillet CD, Milano PM, Boucher RC, Patterson C, Rich PB. ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1988-96. PMID 16361361 DOI: 10.1152/ajpheart.00344.2005  0.4
2006 Grubb BR, Gabriel SE, Mengos A, Gentzsch M, Randell SH, Van Heeckeren AM, Knowles MR, Drumm ML, Riordan JR, Boucher RC. SERCA pump inhibitors do not correct biosynthetic arrest of ΔF508 CFTR in cystic fibrosis American Journal of Respiratory Cell and Molecular Biology. 34: 355-363. PMID 16284361 DOI: 10.1165/rcmb.2005-0286OC  0.4
2005 Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. The Journal of Biological Chemistry. 280: 35751-9. PMID 16087672 DOI: 10.1074/jbc.M505832200  0.6
2005 Matsui H, Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC. Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces Journal of Immunology. 175: 1090-1099. PMID 16002710  0.4
2005 Douillet CD, Suy S, Zarzaur BL, Robinson WP, Milano PM, Boucher RC, Rich PB. Measurement of free and bound fractions of extracellular ATP in biological solutions using bioluminescence. Luminescence : the Journal of Biological and Chemical Luminescence. 20: 435-41. PMID 15966056 DOI: 10.1002/bio.869  0.4
2005 Highsmith WE, Friedman KJ, Burch LH, Spock A, Silverman LM, Boucher RC, Knowles MR. A CFTR mutation (D1152H) in a family with mild lung disease and normal sweat chlorides. Clinical Genetics. 68: 88-90. PMID 15952991 DOI: 10.1111/j.1399-0004.2005.00459.x  0.4
2005 Perez-Vilar J, Ribeiro CM, Salmon WC, Mabolo R, Boucher RC. Mucin granules are in close contact with tubular elements of the endoplasmic reticulum. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1305-9. PMID 15923355 DOI: 10.1369/jhc.5B6713.2005  0.4
2005 Ribeiro CM, Paradiso AM, Schwab U, Perez-Vilar J, Jones L, O'neal W, Boucher RC. Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia. The Journal of Biological Chemistry. 280: 17798-806. PMID 15746099 DOI: 10.1074/jbc.M410618200  0.6
2005 Perez-Vilar J, Olsen JC, Chua M, Boucher RC. pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. The Journal of Biological Chemistry. 280: 16868-81. PMID 15718243 DOI: 10.1074/jbc.M413289200  0.4
2005 Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC. Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Molecular Biology of the Cell. 16: 2154-67. PMID 15716351 DOI: 10.1091/mbc.E04-11-1010  0.36
2005 Ribeiro CM, Paradiso AM, Carew MA, Shears SB, Boucher RC. Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia. The Journal of Biological Chemistry. 280: 10202-9. PMID 15647273 DOI: 10.1074/jbc.M410617200  0.6
2004 Picher M, Burch LH, Boucher RC. Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis. The Journal of Biological Chemistry. 279: 20234-41. PMID 14993227 DOI: 10.1074/jbc.M400305200  0.4
2003 Coakley RD, Grubb BR, Paradiso AM, Gatzy JT, Johnson LG, Kreda SM, O'Neal WK, Boucher RC. Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium. Proceedings of the National Academy of Sciences of the United States of America. 100: 16083-8. PMID 14668433 DOI: 10.1073/pnas.2634339100  0.4
2003 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG. Role of claudin interactions in airway tight junctional permeability. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L1166-78. PMID 12909588 DOI: 10.1152/ajplung.00182.2003  0.6
2003 Coyne CB, Ribeiro CM, Boucher RC, Johnson LG. Acute mechanism of medium chain fatty acid-induced enhancement of airway epithelial permeability. The Journal of Pharmacology and Experimental Therapeutics. 305: 440-50. PMID 12606647 DOI: 10.1124/jpet.102.047654  0.6
2003 Picher M, Burch LH, Hirsh AJ, Spychala J, Boucher RC. Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. The Journal of Biological Chemistry. 278: 13468-79. PMID 12560324 DOI: 10.1074/jbc.M300569200  0.4
2002 Coyne CB, Vanhook MK, Gambling TM, Carson JL, Boucher RC, Johnson LG. Regulation of airway tight junctions by proinflammatory cytokines. Molecular Biology of the Cell. 13: 3218-34. PMID 12221127 DOI: 10.1091/mbc.E02-03-0134  0.6
1997 Highsmith WE, Burch LH, Zhou Z, Olsen JC, Strong TV, Smith T, Friedman KJ, Silverman LM, Boucher RC, Collins FS, Knowles MR. Identification of a splice site mutation (2789 +5 G > A) associated with small amounts of normal CFTR mRNA and mild cystic fibrosis. Human Mutation. 9: 332-8. PMID 9101293 DOI: 10.1002/(SICI)1098-1004(1997)9:4<332::AID-HUMU5>3.0.CO;2-7  0.4
1995 Burch LH, Talbot CR, Knowles MR, Canessa CM, Rossier BC, Boucher RC. Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways. The American Journal of Physiology. 269: C511-8. PMID 7653534  0.4
1994 Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proceedings of the National Academy of Sciences of the United States of America. 91: 3275-9. PMID 8159738  0.4
1994 Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proceedings of the National Academy of Sciences of the United States of America. 91: 13067. PMID 7809171  0.4
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