Chad Cowan - Publications

Harvard University, Cambridge, MA, United States 
Diabetes, Coronary artery disease

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L, Soukas AA, ... ... Cowan CA, et al. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 179: 1276-1288.e14. PMID 31778654 DOI: 10.1016/J.Cell.2019.10.034  0.32
2019 Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA. Generation of hypoimmunogenic human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040209 DOI: 10.1073/Pnas.1902566116  0.64
2016 Pope BD, Warren CR, Parker KK, Cowan CA. Microenvironmental Control of Adipocyte Fate and Function. Trends in Cell Biology. PMID 27268909 DOI: 10.1016/J.Tcb.2016.05.005  0.64
2016 Friesen M, Hudak CS, Warren CR, Xia F, Cowan CA. Adipocyte insulin receptor activity maintains adipose tissue mass and prolongs lifespan. Biochemical and Biophysical Research Communications. PMID 27246738 DOI: 10.1016/j.bbrc.2016.05.151  0.64
2016 Peters DT, Henderson CA, Warren CR, Friesen M, Xia F, Becker CE, Musunuru K, Cowan CA. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells. Development (Cambridge, England). 143: 1475-81. PMID 27143754 DOI: 10.1242/dev.132209  0.64
2016 Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 27078102 DOI: 10.1073/Pnas.1602886113  0.64
2016 Yu H, Cowan CA. Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. Molecular Endocrinology (Baltimore, Md.). me20151290. PMID 27075706 DOI: 10.1210/me.2015-1290  0.64
2016 Hendriks WT, Warren CR, Cowan CA. Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Cell Stem Cell. 18: 53-65. PMID 26748756 DOI: 10.1016/j.stem.2015.12.002  0.64
2015 Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, ... ... Cowan CA, et al. A comparison of non-integrating reprogramming methods. Nature Biotechnology. 33: 58-63. PMID 25437882 DOI: 10.1038/nbt.3070  0.64
2014 Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, ... ... Cowan CA, et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 15: 643-52. PMID 25517468 DOI: 10.1016/J.Stem.2014.10.004  0.64
2014 Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA. Genome editing for human gene therapy. Methods in Enzymology. 546: 273-95. PMID 25398345 DOI: 10.1016/B978-0-12-801185-0.00013-1  0.64
2014 Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Research. 24: 1420-32. PMID 25367124 DOI: 10.1038/cr.2014.142  0.64
2014 Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circulation Research. 115: 488-92. PMID 24916110 DOI: 10.1161/CIRCRESAHA.115.304351  0.64
2014 Lee YK, Cowan CA. Differentiation of white and brown adipocytes from human pluripotent stem cells. Methods in Enzymology. 538: 35-47. PMID 24529432 DOI: 10.1016/B978-0-12-800280-3.00003-7  0.64
2014 Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, ... ... Cowan CA, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism. 19: 96-108. PMID 24411942 DOI: 10.1016/J.Cmet.2013.12.003  0.64
2013 Ding Q, Cowan CA. Liver in a dish. Cell Research. 23: 1242-3. PMID 23979015 DOI: 10.1038/cr.2013.117  0.64
2013 Lee YK, Cowan CA. White to brite adipocyte transition and back again. Nature Cell Biology. 15: 568-9. PMID 23728463 DOI: 10.1038/ncb2776  0.64
2013 Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs Cell Stem Cell. 12: 393-394. PMID 23561441 DOI: 10.1016/j.stem.2013.03.006  0.64
2013 Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nature Communications. 4: 1367. PMID 23340407 DOI: 10.1038/Ncomms2378  0.64
2013 Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, Durham T, Miri M, Deshpande V, De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R, ... Cowan CA, et al. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell. 152: 642-54. PMID 23333102 DOI: 10.1016/J.Cell.2012.12.033  0.64
2013 Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, ... ... Cowan CA, et al. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 12: 238-51. PMID 23246482 DOI: 10.1016/J.Stem.2012.11.011  0.64
2012 Lau FH, Xia F, Kaplan A, Cerrato F, Greene AK, Taghinia A, Cowan CA, Labow BI. Expression analysis of macrodactyly identifies pleiotrophin upregulation. Plos One. 7: e40423. PMID 22848377 DOI: 10.1371/journal.pone.0040423  0.64
2012 Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 10: 385-97. PMID 22482504 DOI: 10.1016/J.Stem.2012.01.018  0.64
2012 Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, ... ... Cowan CA, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biology. 14: 209-19. PMID 22246346 DOI: 10.1038/Ncb2411  0.64
2011 Schinzel RT, Ahfeldt T, Lau FH, Lee YK, Cowley A, Shen T, Peters D, Lum DH, Cowan CA. Efficient culturing and genetic manipulation of human pluripotent stem cells. Plos One. 6: e27495. PMID 22194785 DOI: 10.1371/journal.pone.0027495  0.64
2011 Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, et al. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470: 95-100. PMID 21270795 DOI: 10.1038/nature09669  0.64
2010 Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 7: 618-30. PMID 20888316 DOI: 10.1016/J.Stem.2010.08.012  0.64
2010 Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, ... ... Cowan CA, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 466: 714-9. PMID 20686566 DOI: 10.1038/Nature09266  0.64
2010 Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, et al. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. The Journal of Clinical Investigation. 120: 1125-39. PMID 20335662 DOI: 10.1172/JCI40120  0.64
2010 Xie D, Chen CC, Ptaszek LM, Xiao S, Cao X, Fang F, Ng HH, Lewin HA, Cowan C, Zhong S. Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species. Genome Research. 20: 804-15. PMID 20219939 DOI: 10.1101/gr.100594.109  0.64
2010 Tenzen T, Zembowicz F, Cowan CA. Genome modification in human embryonic stem cells Journal of Cellular Physiology. 222: 278-281. PMID 19877154 DOI: 10.1002/jcp.21948  0.64
2009 Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. The Journal of Cell Biology. 186: 665-73. PMID 19736317 DOI: 10.1083/jcb.200901040  0.64
2009 Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 4: 103-6. PMID 19200798 DOI: 10.1016/J.Stem.2008.12.001  0.64
2008 Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. Plos Genetics. 4: e1000242. PMID 18974828 DOI: 10.1371/Journal.Pgen.1000242  0.64
2008 Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell. 134: 877-86. PMID 18691744 DOI: 10.1016/j.cell.2008.07.041  0.64
2008 Fenno LE, Ptaszek LM, Cowan CA. Human embryonic stem cells: emerging technologies and practical applications Current Opinion in Genetics and Development. 18: 324-329. PMID 18625311 DOI: 10.1016/j.gde.2008.06.004  0.64
2008 Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/nbt1383  0.64
2007 Ptaszek LM, Cowan CA. New Tools for Genome Modification in Human Embryonic Stem Cells Cell Stem Cell. 1: 600-602. PMID 18371400 DOI: 10.1016/j.stem.2007.11.004  0.64
2006 Akutsu H, Cowan CA, Melton D. Human Embryonic Stem Cells Methods in Enzymology. 418: 78-92. PMID 17141030 DOI: 10.1016/S0076-6879(06)18005-2  0.64
2005 Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.). 309: 1369-73. PMID 16123299 DOI: 10.1126/Science.1116447  0.64
2005 Wang S, Cowan CA, Chipperfield H, Powers RD. Gene expression in the preimplantation embryo: in-vitro developmental changes. Reproductive Biomedicine Online. 10: 607-16. PMID 15949218  0.64
2004 Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Developmental Biology. 271: 263-71. PMID 15223333 DOI: 10.1016/J.Ydbio.2004.03.026  0.64
2004 Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. The Journal of Biological Chemistry. 279: 31590-8. PMID 15148312 DOI: 10.1074/jbc.M403547200  0.64
2004 Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. The New England Journal of Medicine. 350: 1353-6. PMID 14999088 DOI: 10.1056/Nejmsr040330  0.64
2002 Cowan CA, Henkemeyer M. Ephrins in reverse, park and drive. Trends in Cell Biology. 12: 339-46. PMID 12185851 DOI: 10.1016/S0962-8924(02)02317-6  0.64
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