Penny A. Jeggo, Ph.D. - Publications

Genome Damage and Stability Centre University of Sussex, Falmer, England, United Kingdom 
DNA Repair, Genomic Stability

186 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sato H, Jeggo PA, Shibata A. Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine. Cancer Science. PMID 31513320 DOI: 10.1111/cas.14197  0.64
2019 Löbrich M, Jeggo PA. Hazards of human spaceflight. Science (New York, N.Y.). 364: 127-128. PMID 30975876 DOI: 10.1126/science.aaw7086  0.64
2017 Jeggo PA, Löbrich M. DNA non-homologous end-joining enters the resection arena. Oncotarget. 8: 93317-93318. PMID 29212151 DOI: 10.18632/oncotarget.22075  0.64
2017 Jeggo PA, Löbrich M. DNA non-homologous end-joining enters the resection arena. Oncotarget. 8: 93317-93318. PMID 29212151 DOI: 10.18632/oncotarget.22075  0.64
2017 Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Molecular Cell. PMID 28132842 DOI: 10.1016/j.molcel.2016.12.016  0.64
2016 Barazzuol L, Jeggo PA. In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation. Journal of Radiation Research. PMID 27125639 DOI: 10.1093/jrr/rrw013  1
2016 Stiff T, Casar Tena T, O'Driscoll M, Jeggo PA, Philipp M. ATR promotes cilia signalling; links to developmental impacts. Human Molecular Genetics. PMID 26908596 DOI: 10.1093/hmg/ddw034  0.48
2015 Kakarougkas A, Downs JA, Jeggo PA. The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & Cellular Oncology. 2: e970072. PMID 27308404 DOI: 10.4161/23723548.2014.970072  0.32
2015 Jeggo PA, Pearl LH, Carr AM. DNA repair, genome stability and cancer: a historical perspective. Nature Reviews. Cancer. PMID 26667849 DOI: 10.1038/nrc.2015.4  1
2015 Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ, Pearl LH. ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX. Cell Reports. PMID 26628370 DOI: 10.1016/j.celrep.2015.10.074  1
2015 Jeggo PA, Löbrich M. How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability. The Biochemical Journal. 471: 1-11. PMID 26392571 DOI: 10.1042/BJ20150582  1
2015 Barazzuol L, Rickett N, Ju L, Jeggo PA. Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells. Journal of Cell Science. 128: 3597-606. PMID 26303202 DOI: 10.1242/jcs.171223  1
2015 Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, et al. XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. The Journal of Allergy and Clinical Immunology. PMID 26255102 DOI: 10.1016/j.jaci.2015.06.007  1
2015 Alagoz M, Katsuki Y, Ogiwara H, Ogi T, Shibata A, Kakarougkas A, Jeggo P. SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells. Nucleic Acids Research. 43: 7931-44. PMID 26206670 DOI: 10.1093/nar/gkv722  1
2015 Lobachevsky P, Woodbine L, Hsiao KC, Choo S, Fraser C, Gray P, Smith J, Best N, Munforte L, Korneeva E, Martin RF, Jeggo PA, Martin OA. Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity. The Journal of Molecular Diagnostics : Jmd. PMID 26151233 DOI: 10.1016/j.jmoldx.2015.05.004  1
2015 Woodbine L, Haines J, Coster M, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P. The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields International Journal of Radiation Biology. 91: 495-499. PMID 25786477 DOI: 10.3109/09553002.2015.1021963  1
2014 Jeggo PA, Downs JA. Roles of chromatin remodellers in DNA double strand break repair. Experimental Cell Research. 329: 69-77. PMID 25278484 DOI: 10.1016/j.yexcr.2014.09.023  1
2014 Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. The Journal of Cell Biology. 206: 877-94. PMID 25267294 DOI: 10.1083/jcb.201401146  1
2014 Saha S, Woodbine L, Haines J, Coster M, Ricket N, Barazzuol L, Ainsbury E, Sienkiewicz Z, Jeggo P. Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields. Journal of the Royal Society, Interface / the Royal Society. 11: 20140783. PMID 25209403 DOI: 10.1098/rsif.2014.0783  1
2014 Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA. Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell. 55: 723-32. PMID 25066234 DOI: 10.1016/j.molcel.2014.06.028  1
2014 Jeggo P, Gounari F. Robin Holliday 1932-2014 Nature Structural & Molecular Biology. 21: 501-502. PMID 24896809 DOI: 10.1038/nsmb.2835  1
2014 Woodbine L, Gennery AR, Jeggo PA. Reprint of "The clinical impact of deficiency in DNA non-homologous end-joining". Dna Repair. 17: 9-20. PMID 24780557 DOI: 10.1016/j.dnarep.2014.04.002  1
2014 Shibata A, Jeggo PA. DNA double-strand break repair in a cellular context. Clinical Oncology (Royal College of Radiologists (Great Britain)). 26: 243-9. PMID 24630811 DOI: 10.1016/j.clon.2014.02.004  1
2014 Woodbine L, Gennery AR, Jeggo PA. The clinical impact of deficiency in DNA non-homologous end-joining. Dna Repair. 16: 84-96. PMID 24629483 DOI: 10.1016/j.dnarep.2014.02.011  1
2014 Kakarougkas A, Jeggo PA. DNA DSB repair pathway choice: an orchestrated handover mechanism. The British Journal of Radiology. 87: 20130685. PMID 24363387 DOI: 10.1259/bjr.20130685  1
2014 Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, ... ... Jeggo PA, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Molecular Cell. 53: 7-18. PMID 24316220 DOI: 10.1016/j.molcel.2013.11.003  1
2013 Lee PP, Woodbine L, Gilmour KC, Bibi S, Cale CM, Amrolia PJ, Veys PA, Davies EG, Jeggo PA, Jones A. The many faces of Artemis-deficient combined immunodeficiency - Two patients with DCLRE1C mutations and a systematic literature review of genotype-phenotype correlation. Clinical Immunology (Orlando, Fla.). 149: 464-74. PMID 24230999 DOI: 10.1016/j.clim.2013.08.006  1
2013 Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. Dna Repair. 12: 936-46. PMID 24041488 DOI: 10.1016/j.dnarep.2013.08.009  1
2013 Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA. Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Research. 41: 10298-311. PMID 24013561 DOI: 10.1093/nar/gkt802  1
2013 Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA. Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Research. 41: 9719-31. PMID 23969417 DOI: 10.1093/nar/gkt729  1
2013 Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P, Shibata A. Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. Plos One. 8: e70107. PMID 23967070 DOI: 10.1371/journal.pone.0070107  1
2013 Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P. Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity. Dna Repair. 12: 844-55. PMID 23891250 DOI: 10.1016/j.dnarep.2013.07.002  1
2013 Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. Brief report: A human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors Stem Cells. 31: 2015-2023. PMID 23818183 DOI: 10.1002/stem.1456  1
2013 Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA. PRKDC mutations in a SCID patient with profound neurological abnormalities. The Journal of Clinical Investigation. 123: 2969-80. PMID 23722905 DOI: 10.1172/JCI67349  1
2013 Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, et al. A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors Cell Death and Differentiation. 20: 1089-1100. PMID 23722522 DOI: 10.1038/cdd.2013.44  1
2013 Goodarzi AA, Jeggo PA. The repair and signaling responses to DNA double-strand breaks. Advances in Genetics. 82: 1-45. PMID 23721719 DOI: 10.1016/B978-0-12-407676-1.00001-9  1
2013 Stiff T, Alagoz M, Alcantara D, Outwin E, Brunner HG, Bongers EM, O'Driscoll M, Jeggo PA. Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome. Plos Genetics. 9: e1003360. PMID 23516378 DOI: 10.1371/journal.pgen.1003360  1
2013 Zimmerman KM, Jones RM, Petermann E, Jeggo PA. Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress. Molecular Cancer Research : McR. 11: 370-80. PMID 23364533 DOI: 10.1158/1541-7786.MCR-12-0491  1
2013 Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P. A noncatalytic function of the ligation complex during nonhomologous end joining. The Journal of Cell Biology. 200: 173-86. PMID 23337116 DOI: 10.1083/jcb.201203128  1
2012 Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, ... ... Jeggo PA, et al. Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. Plos Genetics. 8: e1002945. PMID 23144622 DOI: 10.1371/journal.pgen.1002945  1
2012 Goodarzi AA, Jeggo PA. The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. International Journal of Molecular Sciences. 13: 11844-60. PMID 23109886 DOI: 10.3390/ijms130911844  1
2012 Pernot E, Hall J, Baatout S, Benotmane MA, Blanchardon E, Bouffler S, El Saghire H, Gomolka M, Guertler A, Harms-Ringdahl M, Jeggo P, Kreuzer M, Laurier D, Lindholm C, Mkacher R, et al. Ionizing radiation biomarkers for potential use in epidemiological studies. Mutation Research. 751: 258-86. PMID 22677531 DOI: 10.1016/j.mrrev.2012.05.003  1
2012 Lee DH, Goodarzi AA, Adelmant GO, Pan Y, Jeggo PA, Marto JA, Chowdhury D. Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. The Embo Journal. 31: 2403-15. PMID 22491012 DOI: 10.1038/emboj.2012.86  1
2012 Murray JM, Stiff T, Jeggo PA. DNA double-strand break repair within heterochromatic regions. Biochemical Society Transactions. 40: 173-8. PMID 22260685 DOI: 10.1042/BST20110631  1
2012 Goodarzi AA, Jeggo PA. Irradiation induced foci (IRIF) as a biomarker for radiosensitivity. Mutation Research. 736: 39-47. PMID 21651917 DOI: 10.1016/j.mrfmmm.2011.05.017  1
2011 Kato TA, Okayasu R, Jeggo PA, Fujimori A. ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy. International Journal of Radiation Biology. 87: 1189-95. PMID 21923303 DOI: 10.3109/09553002.2011.624152  1
2011 Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A. Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. Molecular and Cellular Biology. 31: 4022-35. PMID 21791604 DOI: 10.1128/MCB.05289-11  1
2011 Jeggo PA, Geuting V, Löbrich M. The role of homologous recombination in radiation-induced double-strand break repair. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 101: 7-12. PMID 21737170 DOI: 10.1016/j.radonc.2011.06.019  1
2011 Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ, Liu C, Jeggo PA. Requirement for DNA ligase IV during embryonic neuronal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10088-100. PMID 21734301 DOI: 10.1523/JNEUROSCI.1324-11.2011  1
2011 Goodarzi AA, Kurka T, Jeggo PA. KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nature Structural & Molecular Biology. 18: 831-9. PMID 21642969 DOI: 10.1038/nsmb.2077  1
2011 Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Research. 39: 6986-97. PMID 21596788 DOI: 10.1093/nar/gkr331  1
2011 Deckbar D, Jeggo PA, Löbrich M. Understanding the limitations of radiation-induced cell cycle checkpoints. Critical Reviews in Biochemistry and Molecular Biology. 46: 271-83. PMID 21524151 DOI: 10.3109/10409238.2011.575764  1
2011 Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O'Driscoll M, Jeggo PA. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genetics. 43: 350-5. PMID 21358633 DOI: 10.1038/ng.776  1
2011 Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA. Factors determining DNA double-strand break repair pathway choice in G2 phase. The Embo Journal. 30: 1079-92. PMID 21317870 DOI: 10.1038/emboj.2011.27  1
2011 Lobrich M, Goodarzi AA, Stiff T, Jeggo PA. Checkpoint control following radiation exposure Current Cancer Research. 19: 53-77. DOI: 10.1007/978-1-4419-8044-1_3  1
2010 Goodarzi AA, Jeggo P, Lobrich M. The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. Dna Repair. 9: 1273-82. PMID 21036673 DOI: 10.1016/j.dnarep.2010.09.013  1
2010 Jeggo PA. A break is not the End; insight into the damage response to DNA double strand breaks. Dna Repair. 9: 1217-8. PMID 20956092 DOI: 10.1016/j.dnarep.2010.09.021  1
2010 Jeggo P. The role of the DNA damage response mechanisms after low-dose radiation exposure and a consideration of potentially sensitive individuals Radiation Research. 174: 825-832. PMID 20738172 DOI: 10.1667/RR1844.1  1
2010 Woodbine L, Grigoriadou S, Goodarzi AA, Riballo E, Tape C, Oliver AW, van Zelm MC, Buckland MS, Davies EG, Pearl LH, Jeggo PA. An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. Dna Repair. 9: 1003-10. PMID 20674517 DOI: 10.1016/j.dnarep.2010.07.001  1
2010 Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Molecular Cancer Therapeutics. 9: 1775-87. PMID 20530711 DOI: 10.1158/1535-7163.MCT-09-1027  1
2010 Deckbar D, Stiff T, Koch B, Reis C, Löbrich M, Jeggo PA. The limitations of the G1-S checkpoint. Cancer Research. 70: 4412-21. PMID 20460507 DOI: 10.1158/0008-5472.CAN-09-3198  1
2010 Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA. Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Molecular and Cellular Biology. 30: 3371-83. PMID 20421415 DOI: 10.1128/MCB.01644-09  1
2010 Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (Georgetown, Tex.). 9: 662-9. PMID 20139725  1
2010 Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature Cell Biology. 12: 177-84. PMID 20081839 DOI: 10.1038/ncb2017  1
2010 Lee JH, Goodarzi AA, Jeggo PA, Paull TT. 53BP1 promotes ATM activity through direct interactions with the MRN complex. The Embo Journal. 29: 574-85. PMID 20010693 DOI: 10.1038/emboj.2009.372  1
2009 Goodarzi AA, Jeggo PA. 'A mover and a shaker': 53BP1 allows DNA doublestrand breaks a chance to dance and unite. F1000 Biology Reports. 1: 21. PMID 20948664 DOI: 10.3410/B1-21  1
2009 Jeggo P, Lavin MF. Cellular radiosensitivity: How much better do we understand it? International Journal of Radiation Biology. 85: 1061-1081. PMID 19995233 DOI: 10.3109/09553000903261263  1
2009 Jeggo PA. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health Physics. 97: 416-25. PMID 19820451 DOI: 10.1097/HP.0b013e3181aff9c8  1
2009 Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. The Embo Journal. 28: 3413-27. PMID 19779458 DOI: 10.1038/emboj.2009.276  1
2009 Covo S, de Villartay JP, Jeggo PA, Livneh Z. Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research. 37: 6737-45. PMID 19762482 DOI: 10.1093/nar/gkp703  1
2009 Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, Jones M, Turner GD, Jeggo PA, Goodnow CC, Cornall RJ. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. The Journal of Clinical Investigation. 119: 1696-705. PMID 19451691 DOI: 10.1172/JCI32743  1
2009 Goodarzi AA, Noon AT, Jeggo PA. The impact of heterochromatin on DSB repair. Biochemical Society Transactions. 37: 569-76. PMID 19442252 DOI: 10.1042/BST0370569  1
2009 Riballo E, Woodbine L, Stiff T, Walker SA, Goodarzi AA, Jeggo PA. XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research. 37: 482-92. PMID 19056826 DOI: 10.1093/nar/gkn957  1
2008 Stiff T, Cerosaletti K, Concannon P, O'Driscoll M, Jeggo PA. Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1. Human Molecular Genetics. 17: 3247-53. PMID 18664457 DOI: 10.1093/hmg/ddn220  1
2008 Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Molecular Cell. 31: 167-77. PMID 18657500 DOI: 10.1016/j.molcel.2008.05.017  1
2008 O'Driscoll M, Jeggo PA. The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders. Dna Repair. 7: 1039-50. PMID 18458003 DOI: 10.1016/j.dnarep.2008.03.018  1
2008 O'Driscoll M, Jeggo PA. CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair. Bone Marrow Transplantation. 41: 983-9. PMID 18278071 DOI: 10.1038/bmt.2008.18  1
2008 Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics. 40: 232-6. PMID 18157127 DOI: 10.1038/ng.2007.80  1
2008 Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA. The maintenance of ATM dependent G2/M checkpoint arrest following exposure to ionizing radiation Acta Medica Nagasakiensia. 53: 19-21.  1
2008 Goodarzi AA, Noon AT, Jeggo PA. Heterochromatic DNA double strand break repair Acta Medica Nagasakiensia. 53: 13-17.  1
2007 Jeggo PA, Löbrich M. DNA double-strand breaks: their cellular and clinical impact? Oncogene. 26: 7717-9. PMID 18066083 DOI: 10.1038/sj.onc.1210868  1
2007 Löbrich M, Jeggo PA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nature Reviews. Cancer. 7: 861-9. PMID 17943134 DOI: 10.1038/nrc2248  1
2007 Kegel P, Riballo E, Kühne M, Jeggo PA, Löbrich M. X-irradiation of cells on glass slides has a dose doubling impact. Dna Repair. 6: 1692-7. PMID 17644493 DOI: 10.1016/j.dnarep.2007.05.013  1
2007 Krempler A, Deckbar D, Jeggo PA, Löbrich M. An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (Georgetown, Tex.). 6: 1682-6. PMID 17637566  1
2007 O'Driscoll M, Dobyns WB, van Hagen JM, Jeggo PA. Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling. American Journal of Human Genetics. 81: 77-86. PMID 17564965 DOI: 10.1086/518696  1
2007 Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature. 447: 686-90. PMID 17554302 DOI: 10.1038/nature05875  1
2007 Deckbar D, Birraux J, Krempler A, Tchouandong L, Beucher A, Walker S, Stiff T, Jeggo P, Löbrich M. Chromosome breakage after G2 checkpoint release Journal of Cell Biology. 176: 749-755. PMID 17353355 DOI: 10.1083/jcb.200612047  1
2007 Costantini S, Woodbine L, Andreoli L, Jeggo PA, Vindigni A. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. Dna Repair. 6: 712-22. PMID 17241822 DOI: 10.1016/j.dnarep.2006.12.007  1
2006 Jeggo P, Löbrich M. Radiation-induced DNA damage responses Radiation Protection Dosimetry. 122: 124-127. PMID 17351270 DOI: 10.1093/rpd/ncl495  1
2006 Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. The Embo Journal. 25: 5775-82. PMID 17124492 DOI: 10.1038/sj.emboj.7601446  1
2006 O'Driscoll M, Jackson AP, Jeggo PA. Microcephalin: a causal link between impaired damage response signalling and microcephaly. Cell Cycle (Georgetown, Tex.). 5: 2339-44. PMID 17102619  1
2006 Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The Embo Journal. 25: 3880-9. PMID 16874298 DOI: 10.1038/sj.emboj.7601255  1
2006 Jeggo PA, Löbrich M. Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. Dna Repair. 5: 1192-8. PMID 16797253 DOI: 10.1016/j.dnarep.2006.05.011  1
2006 Alderton GK, Galbiati L, Griffith E, Surinya KH, Neitzel H, Jackson AP, Jeggo PA, O'Driscoll M. Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nature Cell Biology. 8: 725-33. PMID 16783362 DOI: 10.1038/ncb1431  1
2006 Marchetti C, Walker SA, Odreman F, Vindigni A, Doherty AJ, Jeggo P. Identification of a novel motif in DNA ligases exemplified by DNA ligase IV Dna Repair. 5: 788-798. PMID 16735143 DOI: 10.1016/j.dnarep.2006.03.011  1
2006 Evans PM, Woodbine L, Riballo E, Gennery AR, Hubank M, Jeggo PA. Radiation-induced delayed cell death in a hypomorphic Artemis cell line. Human Molecular Genetics. 15: 1303-11. PMID 16540517 DOI: 10.1093/hmg/ddl050  1
2006 O'Driscoll M, Jeggo PA. The role of double-strand break repair - insights from human genetics. Nature Reviews. Genetics. 7: 45-54. PMID 16369571 DOI: 10.1038/nrg1746  1
2005 Jeggo PA. Genomic instability in cancer development. Advances in Experimental Medicine and Biology. 570: 175-97. PMID 18727501 DOI: 10.1007/1-4020-3764-3_6  1
2005 Löbrich M, Jeggo PA. The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 112-8. PMID 16026874 DOI: 10.1016/j.radonc.2005.06.027  1
2005 Löbrich M, Jeggo PA. Harmonising the response to DSBs: a new string in the ATM bow. Dna Repair. 4: 749-59. PMID 15978533 DOI: 10.1016/j.dnarep.2004.12.008  1
2005 Cabuy E, Newton C, Joksic G, Woodbine L, Koller B, Jeggo PA, Slijepcevic P. Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiation Research. 164: 53-62. PMID 15966765 DOI: 10.1667/RR3376  1
2005 Gennery AR, Slatter MA, Bhattacharya A, Jeggo PA, Abinun M, Flood TJ, Cant AJ. Bone marrow transplantation for Nijmegan breakage syndrome. Journal of Pediatric Hematology/Oncology. 27: 239. PMID 15838402 DOI: 10.1097/01.mph.0000158257.45823.80  1
2005 Jeggo PA, Löbrich M. Artemis links ATM to double strand break rejoining. Cell Cycle (Georgetown, Tex.). 4: 359-62. PMID 15684609  1
2005 Kysela B, Chovanec M, Jeggo PA. Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proceedings of the National Academy of Sciences of the United States of America. 102: 1877-82. PMID 15671175 DOI: 10.1073/pnas.0401179102  1
2005 Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA. Nbs1 is required for ATR-dependent phosphorylation events. The Embo Journal. 24: 199-208. PMID 15616588 DOI: 10.1038/sj.emboj.7600504  1
2005 Collis SJ, DeWeese TL, Jeggo PA, Parker AR. The life and death of DNA-PK. Oncogene. 24: 949-61. PMID 15592499 DOI: 10.1038/sj.onc.1208332  1
2004 Riballo E, Kühne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Löbrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Molecular Cell. 16: 715-24. PMID 15574327 DOI: 10.1016/j.molcel.2004.10.029  1
2004 Alderton GK, Joenje H, Varon R, Børglum AD, Jeggo PA, O'Driscoll M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Human Molecular Genetics. 13: 3127-38. PMID 15496423 DOI: 10.1093/hmg/ddh335  1
2004 Gennery AR, Slatter MA, Bhattacharya A, Barge D, Haigh S, O'Driscoll M, Coleman R, Abinun M, Flood TJ, Cant AJ, Jeggo PA. The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia. Clinical Immunology (Orlando, Fla.). 113: 214-9. PMID 15451479 DOI: 10.1016/j.clim.2004.03.024  1
2004 Girard PM, Kysela B, Härer CJ, Doherty AJ, Jeggo PA. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics. 13: 2369-76. PMID 15333585 DOI: 10.1093/hmg/ddh274  1
2004 O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. Dna Repair. 3: 1227-35. PMID 15279811 DOI: 10.1016/j.dnarep.2004.03.025  1
2004 Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Research. 64: 2390-6. PMID 15059890 DOI: 10.1158/0008-5472.CAN-03-3207  1
2004 Izsvák Z, Stüwe EE, Fiedler D, Katzer A, Jeggo PA, Ivics Z. Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Molecular Cell. 13: 279-90. PMID 14759372 DOI: 10.1016/S1097-2765(03)00524-0  1
2004 Kühne M, Riballo E, Rief N, Rothkamm K, Jeggo PA, Löbrich M. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Research. 64: 500-8. PMID 14744762 DOI: 10.1158/0008-5472.CAN-03-2384  1
2003 Rünger TM, Kotas M, Poot M, Leverkus M, Epe B, Jeggo PA, Hellfritsch D. Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 24: 100-8. PMID 12853705 DOI: 10.1159/000071083  1
2003 Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, Cao Y, Hamada T, Imamura K, Jeggo PA, Date T, Doherty AJ. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. The Journal of Biological Chemistry. 278: 36487-95. PMID 12824158 DOI: 10.1074/jbc.M304066200  1
2003 O'Driscoll M, Jeggo PA. Clinical impact of ATR checkpoint signalling failure in humans. Cell Cycle (Georgetown, Tex.). 2: 194-5. PMID 12734423  1
2003 Kysela B, Doherty AJ, Chovanec M, Stiff T, Ameer-Beg SM, Vojnovic B, Girard PM, Jeggo PA. Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. The Journal of Biological Chemistry. 278: 22466-74. PMID 12682039 DOI: 10.1074/jbc.M303273200  1
2003 O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nature Genetics. 33: 497-501. PMID 12640452 DOI: 10.1038/ng1129  1
2003 Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA. Nonhomologous end joining and V(D)J recombination require an additional factor. Proceedings of the National Academy of Sciences of the United States of America. 100: 2462-7. PMID 12604777 DOI: 10.1073/pnas.0437964100  1
2002 Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. Journal of Medical Genetics. 39: 900-5. PMID 12471202  1
2002 Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ. Identification of a DNA nonhomologous end-joining complex in bacteria. Science (New York, N.Y.). 297: 1686-9. PMID 12215643 DOI: 10.1126/science.1074584  1
2002 Jeggo PA. The fidelity of repair of radiation damage. Radiation Protection Dosimetry. 99: 117-22. PMID 12194262  1
2002 Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology. 22: 6521-32. PMID 12192050 DOI: 10.1128/MCB.22.18.6521-6532.2002  1
2002 Girard PM, Riballo E, Begg AC, Waugh A, Jeggo PA. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene. 21: 4191-9. PMID 12082606 DOI: 10.1038/sj.onc.1205596  1
2001 Jeggo PA, Concannon P. Immune diversity and genomic stability: opposite goals but similar paths. Journal of Photochemistry and Photobiology. B, Biology. 65: 88-96. PMID 11809363 DOI: 10.1016/S1011-1344(01)00243-3  1
2001 O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Molecular Cell. 8: 1175-85. PMID 11779494 DOI: 10.1016/S1097-2765(01)00408-7  1
2001 Bryntesson F, Regan JC, Jeggo PA, Taccioli GE, Hubank M. Analysis of gene transcription in cells lacking DNA-PK activity. Radiation Research. 156: 167-76. PMID 11448237  1
2001 Marcou Y, D'Andrea A, Jeggo PA, Plowman PN. Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 60: 75-9. PMID 11410307 DOI: 10.1016/S0167-8140(01)00370-X  1
2001 Rothkamm K, Kühne M, Jeggo PA, Löbrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Research. 61: 3886-93. PMID 11358801  1
2001 Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. The Journal of Biological Chemistry. 276: 31124-32. PMID 11349135 DOI: 10.1074/jbc.M103866200  1
2001 Manolis KG, Nimmo ER, Hartsuiker E, Carr AM, Jeggo PA, Allshire RC. Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. The Embo Journal. 20: 210-21. PMID 11226171 DOI: 10.1093/emboj/20.1.210  1
2000 Girard PM, Foray N, Stumm M, Waugh A, Riballo E, Maser RS, Phillips WP, Petrini J, Arlett CF, Jeggo PA. Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects. Cancer Research. 60: 4881-8. PMID 10987302  1
2000 Gennery AR, Cant AJ, Jeggo PA. Immunodeficiency associated with DNA repair defects. Clinical and Experimental Immunology. 121: 1-7. PMID 10886231 DOI: 10.1046/j.1365-2249.2000.01257.x  1
2000 Beamish HJ, Jessberger R, Riballo E, Priestley A, Blunt T, Kysela B, Jeggo PA. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Research. 28: 1506-13. PMID 10710416  1
1999 Peake J, Waugh A, Le Deist F, Priestley A, Rieux-Laucat F, Foray N, Capulas E, Singleton BK, de Villartay JP, Cant A, Malaise EP, Fischer A, Hivroz C, Jeggo PA. Combined immunodeficiency associated with increased apoptosis of lymphocytes and radiosensitivity fibroblasts. Cancer Research. 59: 3454-60. PMID 10416610  1
1999 Woudstra EC, Konings AW, Jeggo PA, Kampinga HH. Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiation Research. 152: 214-8. PMID 10409332 DOI: 10.2307/3580096  1
1999 Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank M. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 400: 81-3. PMID 10403253 DOI: 10.1038/21913  1
1999 Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Current Biology : Cb. 9: 699-702. PMID 10395545 DOI: 10.1016/S0960-9822(99)80311-X  1
1999 Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Molecular and Cellular Biology. 19: 3267-77. PMID 10207052  1
1998 Jeggo PA. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiation Research. 150: S80-91. PMID 9806611  1
1998 Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 9: 355-66. PMID 9768755 DOI: 10.1016/S1074-7613(00)80618-4  1
1998 Jeggo PA, Carr AM, Lehmann AR. Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends in Genetics : Tig. 14: 312-6. PMID 9724963 DOI: 10.1016/S0168-9525(98)01511-X  1
1998 Escarceller M, Buchwald M, Singleton BK, Jeggo PA, Jackson SP, Moustacchi E, Papadopoulo D. Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining. Journal of Molecular Biology. 279: 375-85. PMID 9642044 DOI: 10.1006/jmbi.1998.1784  1
1998 Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, Smith GC, Blunt T, Schalkwyk LC, Bedford JS, Jackson SP, Jeggo PA, Taccioli GE. Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Research. 26: 1965-73. PMID 9518490 DOI: 10.1093/nar/26.8.1965  1
1998 Jeggo PA. DNA repair: PARP - another guardian angel? Current Biology : Cb. 8: R49-51. PMID 9427640  1
1998 Jeggo PA. 5 DNA Breakage and Repair Advances in Genetics. 38: 185-218. DOI: 10.1016/S0065-2660(08)60144-3  1
1997 Jeggo PA. DNA-PK: at the cross-roads of biochemistry and genetics. Mutation Research. 384: 1-14. PMID 9201268 DOI: 10.1016/S0921-8777(97)00009-8  1
1997 Singleton BK, Priestley A, Steingrimsdottir H, Gell D, Blunt T, Jackson SP, Lehmann AR, Jeggo PA. Molecular and biochemical characterization of xrs mutants defective in Ku80. Molecular and Cellular Biology. 17: 1264-73. PMID 9032253  1
1996 Blunt T, Gell D, Fox M, Taccioli GE, Lehmann AR, Jackson SP, Jeggo PA. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proceedings of the National Academy of Sciences of the United States of America. 93: 10285-90. PMID 8816792 DOI: 10.1073/pnas.93.19.10285  1
1996 Liang F, Romanienko PJ, Weaver DT, Jeggo PA, Jasin M. Chromosomal double-strand break repair in Ku80-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8929-33. PMID 8799130 DOI: 10.1073/pnas.93.17.8929  1
1996 Jeggo PA, Jackson SP, Taccioli GE. Identification of the catalytic subunit of DNA dependent protein kinase as the product of the mouse scid gene Current Topics in Microbiology and Immunology. 217: 79-89. PMID 8787619  1
1995 Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, Schurr E, Lehmann AR, Jeggo PA. A YAC Contig Encompassing the XRCC5 (Ku80) DNA Repair Gene and Complementation of Defective Cells by YAC Protoplast Fusion Genomics. 30: 320-328. PMID 8586433 DOI: 10.1006/geno.1995.9871  1
1995 Jackson SP, Jeggo PA. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK Trends in Biochemical Sciences. 20: 412-415. PMID 8533154 DOI: 10.1016/S0968-0004(00)89090-8  1
1995 Jeggo PA, Taccioli GE, Jackson SP. Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK Bioessays. 17: 949-957. PMID 8526889  1
1995 Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation Cell. 80: 813-823. PMID 7889575 DOI: 10.1016/0092-8674(95)90360-7  1
1995 Ross GM, Eady JJ, Mithal NP, Bush C, Steel GG, Jeggo PA, McMillan TJ. DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene Cancer Research. 55: 1235-1238. PMID 7882315  1
1995 Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP. DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair Proceedings of the National Academy of Sciences of the United States of America. 92: 320-324. PMID 7816841 DOI: 10.1073/pnas.92.1.320  1
1995 Zdzienicka MZ, Jongmans W, Oshimura M, Priestley A, Whitmore GF, Jeggo PA. Complementation analysis of the murine scid cell line Radiation Research. 143: 238-244. PMID 7652160 DOI: 10.2307/3579209  1
1995 Thompson LH, Jeggo PA. Nomenclature of human genes involved in ionizing radiation sensitivity Mutation Research-Dna Repair. 337: 131-134. PMID 7565861 DOI: 10.1016/0921-8777(95)00018-F  1
1994 Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA. Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination Science. 265: 1442-1445. PMID 8073286  1
1994 Jeggo PA, Carr AM, Lehmann AR. Cloning human DNA repair genes International Journal of Radiation Biology. 66: 573-577. PMID 7983449 DOI: 10.1080/09553009414551651  1
1994 Hafezparast M, Cole CG, Kaur GP, Athwal RS, Jeggo PA. An extended panel of hamster-human hybrids for chromosome 2q Somatic Cell and Molecular Genetics. 20: 541-548. PMID 7892651 DOI: 10.1007/BF02255844  1
1993 Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW. Impairment of V(D)J recombination in double-strand break repair mutants Science. 260: 207-210. PMID 8469973  1
1993 Jeggo PA, Hafezparast M, Thompson AF, Kaur GP, Sandhu AK, Athwal RS. A hamster-human subchromosomal hybrid cell panel for chromosome 2. Somatic Cell and Molecular Genetics. 19: 39-49. PMID 8460397 DOI: 10.1007/BF01233953  1
1993 Hafezparast M, Kaur GP, Zdzienicka M, Athwal RS, Lehmann AR, Jeggo PA. Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36 Somatic Cell and Molecular Genetics. 19: 413-421. PMID 8291019 DOI: 10.1007/BF01233246  1
1993 Harvey CB, Fox MF, Jeggo PA, Mantei N, Povey S, Swallow DM. Regional localization of the lactase-phlorizin hydrolase gene, LCT, to chromosome 2q21 Annals of Human Genetics. 57: 179-185. PMID 8257087  1
1993 Dahm-Daphi J, Dikomey E, Pyttlik C, Jeggo PA. Reparable and non-reparable DNA Strand breaks induced by x-irradiation in CHO k1 cells and the radiosensitive mutants xrs1 and xrs5 International Journal of Radiation Biology. 64: 19-26. PMID 8102167 DOI: 10.1080/09553009314551071  1
1992 Jeggo PA, Hafezparast M, Thompson AF, Broughton BC, Kaur GP, Zdzienicka MZ, Athwal RS. Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2 Proceedings of the National Academy of Sciences of the United States of America. 89: 6423-6427. PMID 1631138  1
1991 Jeggo PA, Tesmer J, Chen DJ. Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines Mutation Research-Dna Repair. 254: 125-133. PMID 2002809 DOI: 10.1016/0921-8777(91)90003-8  1
1990 Jeggo PA. Studies on mammalian mutants defective in rejoining double-strand breaks in DNA Mutation Research/Reviews in Genetic Toxicology. 239: 1-16. PMID 2195330 DOI: 10.1016/0165-1110(90)90028-A  1
1989 Jeggo PA, Smith-Ravin J. Decreased stable transfection frequencies of six X-ray-sensitive CHO strains, all members of the xrs complementation group Mutation Research-Dna Repair. 218: 75-86. PMID 2770766 DOI: 10.1016/0921-8777(89)90013-X  1
1989 Smith-Ravin J, Jeggo PA. Use of damaged plasmid to study DNA repair in x-ray sensitive (xrs) strains of chinese hamster ovary (CHO) cells International Journal of Radiation Biology. 56: 951-961. PMID 2574223 DOI: 10.1080/09553008914552411  1
1989 Jeggo PA, Caldecott K, Pidsley S, Banks GR. Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors. Cancer Research. 49: 7057-63. PMID 2479475  1
1987 Bryant PE, Birch DA, Jeggo PA. High chromosomal sensitivity of chinese hamster xrs 5 cells to restriction endonuclease induced DNA double-Strand breaks International Journal of Radiation Biology. 52: 537-554. PMID 2822587 DOI: 10.1080/09553008714552041  1
1987 Gounari F, Banks GR, Khazaie K, Jeggo PA, Holliday R. Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants. Genes & Development. 1: 899-912. PMID 2448188  1
1986 Kemp LM, Jeggo PA. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line Mutation Research Dna Repair Reports. 166: 255-263. PMID 3785270 DOI: 10.1016/0167-8817(86)90025-8  1
1986 Jeggo PA, Holliday R. Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells. Molecular and Cellular Biology. 6: 2944-9. PMID 2431295  1
1985 Jeggo PA. Genetic analysis of X-ray-sensitive mutants of the CHO cell line Mutation Research Dna Repair Reports. 146: 265-270. PMID 4058443 DOI: 10.1016/0167-8817(85)90067-7  1
1985 Jeggo PA. X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis Mutation Research Dna Repair Reports. 145: 171-176. PMID 4039031 DOI: 10.1016/0167-8817(85)90024-0  1
1985 Holliday R, Jeggo PA. Mechanisms for changing gene expression and their possible relationship to carcinogenesis. Cancer Surveys. 4: 557-81. PMID 3916656  1
1984 Kemp LM, Sedgwick SG, Jeggo PA. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining Mutation Research Dna Repair Reports. 132: 189-196. PMID 6513971 DOI: 10.1016/0167-8817(84)90037-3  1
1983 Jeggo PA, Kemp LM. X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents Mutation Research Dna Repair Reports. 112: 313-327. PMID 6197643 DOI: 10.1016/0167-8817(83)90026-3  1
1982 Jeggo PA, Kemp LM, Holliday R. The application of the microbial "tooth-pick" technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of Chinese hamster ovary cells. Biochimie. 64: 713-5. PMID 6814519 DOI: 10.1016/S0300-9084(82)80116-8  1
1975 Jeggo PA, Banks GR. DNA polymerase of Ustilago maydis: Partial characterization of the enzyme and a pol 1 mutation Mgg Molecular & General Genetics. 142: 209-224. PMID 1221304 DOI: 10.1007/BF00425646  1
1973 Jeggo PA, Unrau P, Banks GR, Holliday R. A temperature sensitive DNA polymerase mutant of Ustilago maydis. Nature: New Biology. 242: 14-6. PMID 4511837  1
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