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Markos Koutmos, Ph.D. - Publications

Affiliations: 
2005 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Design, Synthesis, Structures and Reactivities of Metal Clusters and Supramolecules
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20/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li Z, Mascarenhas R, Twahir UT, Kallon A, Deb A, Yaw M, Penner-Hahn JE, Koutmos M, Warncke K, Banerjee R. An interprotein Co-S coordination complex in the B12-trafficking pathway. Journal of the American Chemical Society. PMID 32871076 DOI: 10.1021/Jacs.0C06590  0.368
2017 Li Z, Shanmuganathan A, Ruetz M, Yamada K, Lesniak NA, Kraeutler B, Brunold TC, Koutmos M, Banerjee R. Coordination Chemistry Controls the Thiol Oxidase Activity of the B12 Trafficking Protein CblC. The Journal of Biological Chemistry. PMID 28442570 DOI: 10.1074/Jbc.M117.788554  0.306
2015 Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M. Nuclear Protein-only ribonuclease P 2 Structure and Biochemical Characterization Provide Insight Into the Conserved Properties of tRNA 5'-end Processing Enzymes. Journal of Molecular Biology. PMID 26655022 DOI: 10.1016/J.Jmb.2015.11.025  0.312
2015 Yamada K, Gherasim C, Banerjee R, Koutmos M. Structure of Human B12 trafficking protein CblD reveals molecular mimicry and identifies a new subfamily of Nitro-FMN reductases. The Journal of Biological Chemistry. PMID 26364851 DOI: 10.1074/Jbc.M115.682435  0.327
2014 Mládková J, Hladílková J, Diamond CE, Tryon K, Yamada K, Garrow TA, Jungwirth P, Koutmos M, Jiráček J. Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins. 82: 2552-64. PMID 24895213 DOI: 10.1002/Prot.24619  0.3
2010 Koutmos M, Kabil O, Smith JL, Banerjee R. Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 20958-63. PMID 21081698 DOI: 10.1073/Pnas.1011448107  0.318
2010 Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA. A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. Journal of Molecular Biology. 400: 38-51. PMID 20434461 DOI: 10.1016/J.Jmb.2010.04.050  0.326
2009 Koutmos M, Datta S, Pattridge KA, Smith JL, Matthews RG. Insights into the reactivation of cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the United States of America. 106: 18527-32. PMID 19846791 DOI: 10.1073/Pnas.0906132106  0.344
2008 Datta S, Koutmos M, Pattridge KA, Ludwig ML, Matthews RG. A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor. Proceedings of the National Academy of Sciences of the United States of America. 105: 4115-20. PMID 18332423 DOI: 10.1073/Pnas.0800329105  0.308
2008 Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proceedings of the National Academy of Sciences of the United States of America. 105: 3286-91. PMID 18296644 DOI: 10.1073/Pnas.0709960105  0.31
2008 Koutmos M, Georgakaki IP, Tsiolis P, Coucouvanis D. Synthesis and characterization of MoFe3S4 and Mo 2Fe2S4 single cubanes Zeitschrift Fur Anorganische Und Allgemeine Chemie. 634: 255-261. DOI: 10.1002/Zaac.200700419  0.623
2006 Xiao Y, Koutmos M, Case DA, Coucouvanis D, Wang H, Cramer SP. Dynamics of an [Fe4S4(SPh)4]2- cluster explored via IR, Raman, and nuclear resonance vibrational spectroscopy (NRVS)-analysis using 36S substitution, DFT calculations, and empirical force fields. Dalton Transactions (Cambridge, England : 2003). 2192-201. PMID 16673033 DOI: 10.1039/B513331A  0.657
2006 Koutmos M, Georgakaki IP, Coucouvanis D. Borohydride, azide, and chloride anions as terminal ligands on Fe/Mo/S clusters. Synthesis, structure and characterization of [(Cl4-cat)(PPr3) MoFe3S4(X)2]2(Bu4N)4 and [(Cl4-cat)(PPr3)MoFe3S4 (PPr3)(X)]2(Bu4N)2 (X = N3-, BH4-, Cl-) double-fused cubanes. NMR reactivity studies of [(Cl4-cat)(PPr3) MoFe3S4(BH4)2]2(Bu4N)4. Inorganic Chemistry. 45: 3648-56. PMID 16634597 DOI: 10.1021/Ic052156B  0.68
2006 Koutmos M, Coucouvanis D. Metal clusters as ligands. Substitution of fe ions in Fe/Mo/S clusters by thiophilic CuI ions. Inorganic Chemistry. 45: 1421-3. PMID 16471948 DOI: 10.1021/Ic051860P  0.694
2005 Smith MC, Xiao Y, Wang H, George SJ, Coucouvanis D, Koutmos M, Sturhahn W, Alp EE, Zhao J, Cramer SP. Normal-mode analysis of FeCl4- and Fe2S2Cl42- via vibrational mössbauer, resonance Raman, and FT-IR spectroscopies. Inorganic Chemistry. 44: 5562-70. PMID 16060605 DOI: 10.1021/Ic0482584  0.634
2005 Koutmos M, Kalyvas H, Sanakis Y, Simopoulos A, Coucouvanis D. Systematic synthesis of heterometallic Ni/Fe/S and Cu/Fe/S clusters with a pentlandite-like M8S6 core. Journal of the American Chemical Society. 127: 3706-7. PMID 15771499 DOI: 10.1021/Ja042938O  0.68
2005 Koutmos M, Coucouvanis D. Metal clusters as ligands: substitution of Fe ions in Fe/Mo/S clusters by thiophilic Cu(I) ions to give clusters with [Cu4Mo2Fe2S8]4+ and [Cu5Mo3Fe4S11]6+ cores. Angewandte Chemie (International Ed. in English). 44: 1971-4. PMID 15724256 DOI: 10.1002/Anie.200462596  0.678
2004 Koutmos M, Coucouvanis D. Borohydride anions as terminal ligands on a Fe/Mo/S cluster. Synthesis, structure, and characterization of the [(Cl4-cat)(PPr3)MoFe3S4(BH4)2]2(Bu4N)4 double-fused cubane. Inorganic Chemistry. 43: 6508-10. PMID 15476337 DOI: 10.1021/Ic049275W  0.705
2004 Koutmos M, Coucouvanis D. Superclusters: a host-guest complex with a cyclic array of three bridged MoFe3S4 clusters. Angewandte Chemie (International Ed. in English). 43: 5023-5. PMID 15384123 DOI: 10.1002/Anie.200460154  0.625
2001 Han J, Koutmos M, Ahmad SA, Coucouvanis D. Rational synthesis of high nuclearity Mo/Fe/S clusters: the reductive coupling approach in the convenient synthesis of (Cl(4)-cat)(2)Mo(2)Fe(6)S(8)(PR(3))(6) [R = Et, (n)Pr, (n)Bu] and the new [(Cl(4)-cat)(2)Mo(2)Fe(2)S(3)O(PEt(3))(3)Cl]-1/2(Fe(PEt(3))(2)(MeCN)(4)) and (Cl(4)-cat)(2)Mo(2)Fe(3)S(5)(PEt(3))(5) clusters. Inorganic Chemistry. 40: 5985-99. PMID 11681915 DOI: 10.1021/Ic0104914  0.705
Low-probability matches (unlikely to be authored by this person)
2008 Matthews RG, Koutmos M, Datta S. Cobalamin-dependent and cobamide-dependent methyltransferases. Current Opinion in Structural Biology. 18: 658-66. PMID 19059104 DOI: 10.1016/J.Sbi.2008.11.005  0.296
2013 Lofgren M, Koutmos M, Banerjee R. Autoinhibition and signaling by the switch II motif in the G-protein chaperone of a radical B12 enzyme. The Journal of Biological Chemistry. 288: 30980-9. PMID 23996001 DOI: 10.1074/Jbc.M113.499970  0.295
2012 Howard MJ, Lim WH, Fierke CA, Koutmos M. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing. Proceedings of the National Academy of Sciences of the United States of America. 109: 16149-54. PMID 22991464 DOI: 10.1073/Pnas.1209062109  0.292
2016 Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M. Differential substrate recognition by isozymes of plant protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 26966150 DOI: 10.1261/Rna.055541.115  0.291
2013 Lofgren M, Padovani D, Koutmos M, Banerjee R. A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone Nature Chemical Biology. 9: 535-541. PMID 23873214 DOI: 10.1038/Nchembio.1298  0.29
2013 Yadav PK, Yamada K, Chiku T, Koutmos M, Banerjee R. Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. The Journal of Biological Chemistry. 288: 20002-13. PMID 23698001 DOI: 10.1074/Jbc.M113.466177  0.287
2017 Ruetz M, Shanmuganathan A, Gherasim C, Karasik A, Salchner R, Kieninger C, Wurst K, Banerjee R, Koutmos M, Kräutler B. Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate. Angewandte Chemie (International Ed. in English). PMID 28544088 DOI: 10.1002/Anie.201701583  0.286
2017 Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJ, Jackson ND, Koutmos M, Fierke CA. Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 28874505 DOI: 10.1261/Rna.061457.117  0.286
2019 Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R. Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science (New York, N.Y.). 366: 589-593. PMID 31672889 DOI: 10.1126/Science.Aay0934  0.285
2011 Koutmos M, Gherasim C, Smith JL, Banerjee R. Structural basis of multifunctionality in a vitamin B12-processing enzyme. The Journal of Biological Chemistry. 286: 29780-7. PMID 21697092 DOI: 10.1074/Jbc.M111.261370  0.281
2013 Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR. RNase P enzymes: divergent scaffolds for a conserved biological reaction. Rna Biology. 10: 909-14. PMID 23595059 DOI: 10.4161/Rna.24513  0.28
2009 Vanek V, Budesínský M, Kabeleová P, Sanda M, Kozísek M, Hanclová I, Mládková J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jirácek J. Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry. 52: 3652-65. PMID 19534555 DOI: 10.1021/Jm8015798  0.279
2018 Yamada K, Koutmos M. The folate-binding module of Thermus thermophilus cobalamin-dependent methionine synthase displays a distinct variation of the classical TIM barrel: a TIM barrel with a `twist'. Acta Crystallographica. Section D, Structural Biology. 74: 41-51. PMID 29372898 DOI: 10.1107/S2059798317018290  0.273
2008 Szegedi SS, Castro CC, Koutmos M, Garrow TA. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. The Journal of Biological Chemistry. 283: 8939-45. PMID 18230605 DOI: 10.1074/Jbc.M710449200  0.257
2019 Karasik A, Fierke CA, Koutmos M. Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P. Rna (New York, N.Y.). PMID 31455609 DOI: 10.1261/Rna.069310.118  0.248
2011 Koutmos M, Kabil O, Smith JL, Banerjee R. Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 49 (20958-20963) DOI: 10.1073/pnas.1011448107) Proceedings of the National Academy of Sciences of the United States of America. 108: 4512. DOI: 10.1073/Pnas.1102185108  0.234
2013 Ganu R, Garrow T, Koutmos M, Rund L, Schook LB. Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism. Gene. 529: 228-37. PMID 23948084 DOI: 10.1016/J.Gene.2013.07.103  0.234
2015 Ganu RS, Ishida Y, Koutmos M, Kolokotronis SO, Roca AL, Garrow TA, Schook LB. Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes. Plos One. 10: e0134084. PMID 26213999 DOI: 10.1371/Journal.Pone.0134084  0.229
2016 Sen A, Karasik A, Shanmuganathan A, Mirkovic E, Koutmos M, Cox RT. Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila. Nucleic Acids Research. PMID 27131785 DOI: 10.1093/Nar/Gkw338  0.226
2017 Ruetz M, Shanmuganathan A, Gherasim C, Karasik A, Salchner R, Kieninger C, Wurst K, Banerjee R, Koutmos M, Kräutler B. Inhibierung des humanen B12-verarbeitenden Enzyms CblC durch Antivitamine B12- Kristallstruktur des inaktiven ternären Komplexes mit dem Kosubstrat Glutathion Angewandte Chemie. 129: 7493-7498. DOI: 10.1002/Ange.201701583  0.22
2020 Mascarenhas R, Ruetz M, McDevitt L, Koutmos M, Banerjee R. Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B. Proceedings of the National Academy of Sciences of the United States of America. PMID 33199623 DOI: 10.1073/pnas.2007332117  0.2
2022 Yamada K, Mendoza J, Koutmos M. 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity. The Journal of Biological Chemistry. 299: 102855. PMID 36592927 DOI: 10.1016/j.jbc.2022.102855  0.196
2022 Wu Meyers N, Karasik A, Kaitany K, Fierke CA, Koutmos M. Gambogic acid and juglone inhibit RNase P through distinct mechanisms. The Journal of Biological Chemistry. 102683. PMID 36370850 DOI: 10.1016/j.jbc.2022.102683  0.167
2023 Wilhelm CA, Mallik L, Kelly AL, Brotzman S, Mendoza J, Anders AG, Leskaj S, Castillo C, Ruotolo BT, Cianfrocco MA, Koutmos M. Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. The Journal of Biological Chemistry. 105327. PMID 37806495 DOI: 10.1016/j.jbc.2023.105327  0.162
2021 Gouda H, Mascarenhas R, Pillay S, Ruetz M, Koutmos M, Banerjee R. Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions. The Journal of Biological Chemistry. 101373. PMID 34757128 DOI: 10.1016/j.jbc.2021.101373  0.146
2020 Lukowski AL, Mallik L, Hinze ME, Carlson BM, Ellinwood DC, Pyser JB, Koutmos M, Narayan ARH. Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase. Acs Chemical Biology. PMID 32058687 DOI: 10.1021/acschembio.9b00964  0.144
2023 Mendoza J, Purchal M, Yamada K, Koutmos M. Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo. Nature Communications. 14: 6365. PMID 37821448 DOI: 10.1038/s41467-023-42037-4  0.14
2022 Purchal MK, Eyler DE, Tardu M, Franco MK, Korn MM, Khan T, McNassor R, Giles R, Lev K, Sharma H, Monroe J, Mallik L, Koutmos M, Koutmou KS. Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35058356 DOI: 10.1073/pnas.2109708119  0.127
2024 Wilhelm CA, Kaitany K, Kelly A, Yacoub M, Koutmos M. The protein-only RNase Ps, endonucleases that cleave pre-tRNA: Biological relevance, molecular architectures, substrate recognition and specificity, and protein interactomes. Wiley Interdisciplinary Reviews. Rna. 15: e1836. PMID 38453211 DOI: 10.1002/wrna.1836  0.12
2022 Ruetz M, Koutmos M, Kräutler B. Antivitamins B: Synthesis and application as inhibitory ligand of the B-tailoring enzyme CblC. Methods in Enzymology. 668: 157-178. PMID 35589193 DOI: 10.1016/bs.mie.2021.12.016  0.118
2020 Karasik A, Wilhelm CA, Fierke CA, Koutmos M. Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P. Rna (New York, N.Y.). PMID 33380464 DOI: 10.1261/rna.077198.120  0.105
2020 Miller NA, Kaneshiro AK, Konar A, Alonso-Mori R, Britz A, Deb A, Glownia JM, Koralek JD, Mallik L, Meadows JH, Michocki LB, van Driel TB, Koutmos M, Padmanabhan S, Elías-Arnanz M, et al. The Photoactive Excited State of the B-Based Photoreceptor CarH. The Journal of Physical Chemistry. B. PMID 33174757 DOI: 10.1021/acs.jpcb.0c09428  0.102
2024 Tidwell ED, Kilde IR, Leskaj S, Koutmos M. Fluorescent Ligand Equilibrium Displacement: A High-Throughput Method for Identification of FMN Riboswitch-Binding Small Molecules. International Journal of Molecular Sciences. 25. PMID 38255809 DOI: 10.3390/ijms25020735  0.095
2024 Anders AG, Tidwell ED, Gadkari VV, Koutmos M, Ruotolo BT. Collision-Induced Unfolding Reveals Disease-Associated Stability Shifts in Mitochondrial Transfer Ribonucleic Acids. Journal of the American Chemical Society. 146: 4412-4420. PMID 38329282 DOI: 10.1021/jacs.3c09230  0.093
2005 Demadis KD, Katarachia SD, Koutmos M. Crystal growth and characterization of zinc-(amino-tris- (methylenephosphonate)) organic-inorganic hybrid networks and their inhibiting effect on metallic corrosion Inorganic Chemistry Communications. 8: 254-258. DOI: 10.1016/j.inoche.2004.12.019  0.062
2023 DeAngelo SL, Győrffy B, Koutmos M, Shah YM. Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis. Trends in Cancer. PMID 37716885 DOI: 10.1016/j.trecan.2023.08.003  0.061
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