Todd Holyoak, Ph.D. - Publications

Biology University of Waterloo, Waterloo, ON, Canada 
 2000 University of Notre Dame, Notre Dame, IN, United States 
enzyme mechanisms, their regulation and structure and how they are interrelated

25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Johnson TA, Mcleod MJ, Holyoak T. Utilization of substrate intrinsic binding energy for conformational change and catalytic function in phosphoenolpyruvate carboxykinase. Biochemistry. PMID 26709450 DOI: 10.1021/acs.biochem.5b01215  1
2015 Balan MD, Mcleod MJ, Lotosky WR, Ghaly M, Holyoak T. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 54: 5878-87. PMID 26322521 DOI: 10.1021/acs.biochem.5b00822  1
2014 Adams DR, Yuan H, Holyoak T, Arajs KH, Hakimi P, Markello TC, Wolfe LA, Vilboux T, Burton BK, Fajardo KF, Grahame G, Holloman C, Sincan M, Smith AC, Wells GA, et al. Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Molecular Genetics and Metabolism. 113: 161-70. PMID 24863970 DOI: 10.1016/J.Ymgme.2014.04.001  1
2013 Holyoak T, Zhang B, Deng J, Tang Q, Prasannan CB, Fenton AW. Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase. Biochemistry. 52: 466-76. PMID 23270483 DOI: 10.1016/J.Bpj.2012.11.2115  1
2012 Johnson TA, Holyoak T. The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry. 51: 9547-59. PMID 23127136 DOI: 10.1021/bi301278t  1
2011 Park KT, Wu W, Battaile KP, Lovell S, Holyoak T, Lutkenhaus J. The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis. Cell. 146: 396-407. PMID 21816275 DOI: 10.1016/J.Cell.2011.06.042  1
2011 Wu W, Park KT, Holyoak T, Lutkenhaus J. Determination of the structure of the MinD-ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC. Molecular Microbiology. 79: 1515-28. PMID 21231967 DOI: 10.1111/J.1365-2958.2010.07536.X  1
2010 Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. Plos One. 5: e14169. PMID 21152065 DOI: 10.1371/Journal.Pone.0014169  1
2010 Fenton AW, Johnson TA, Holyoak T. The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Science : a Publication of the Protein Society. 19: 1796-800. PMID 20629175 DOI: 10.1002/Pro.450  1
2010 Johnson TA, Holyoak T. Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry. 49: 5176-87. PMID 20476774 DOI: 10.1021/bi100399e  1
2009 Carlson GM, Holyoak T. Structural insights into the mechanism of phosphoenolpyruvate carboxykinase catalysis. The Journal of Biological Chemistry. 284: 27037-41. PMID 19638345 DOI: 10.1074/jbc.R109.040568  1
2009 Johnson TA, Qiu J, Plaut AG, Holyoak T. Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of haemophilus influenzae immunoglobulin A1 protease. Journal of Molecular Biology. 389: 559-74. PMID 19393662 DOI: 10.1016/j.jmb.2009.04.041  1
2009 Katayama H, McGill M, Kearns A, Brzozowski M, Degner N, Harnett B, Kornilayev B, Matković-Calogović D, Holyoak T, Calvet JP, Gogol EP, Seed J, Fisher MT. Strategies for folding of affinity tagged proteins using GroEL and osmolytes. Journal of Structural and Functional Genomics. 10: 57-66. PMID 19082872 DOI: 10.1007/S10969-008-9053-8  1
2008 Sullivan SM, Holyoak T. Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proceedings of the National Academy of Sciences of the United States of America. 105: 13829-34. PMID 18772387 DOI: 10.1073/pnas.0805364105  1
2008 Stiffin RM, Sullivan SM, Carlson GM, Holyoak T. Differential inhibition of cytosolic PEPCK by substrate analogues. Kinetic and structural characterization of inhibitor recognition. Biochemistry. 47: 2099-109. PMID 18197707 DOI: 10.1021/bi7020662  1
2007 Sullivan SM, Holyoak T. Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry. 46: 10078-88. PMID 17685635 DOI: 10.1021/bi701038x  1
2007 Wheatley JL, Holyoak T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proceedings of the National Academy of Sciences of the United States of America. 104: 6626-31. PMID 17426142 DOI: 10.1073/pnas.0701983104  1
2006 Holyoak T, Sullivan SM, Nowak T. Structural insights into the mechanism of PEPCK catalysis. Biochemistry. 45: 8254-63. PMID 16819824 DOI: 10.1021/Bi060269G  1
2006 Williams R, Holyoak T, McDonald G, Gui C, Fenton AW. Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase. Biochemistry. 45: 5421-9. PMID 16634623 DOI: 10.1021/bi0524262  1
2005 Fenn TD, Holyoak T, Stamper GF, Ringe D. Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase. Biochemistry. 44: 5317-27. PMID 15807525 DOI: 10.1021/Bi047842L  1
2004 Holyoak T, Nowak T. pH Dependence of the reaction catalyzed by avian mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 43: 7054-65. PMID 15170343 DOI: 10.1021/Bi049707E  1
2004 Holyoak T, Kettner CA, Petsko GA, Fuller RS, Ringe D. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry. 43: 2412-21. PMID 14992578 DOI: 10.1021/Bi035849H  1
2003 Holyoak T, Fenn TD, Wilson MA, Moulin AG, Ringe D, Petsko GA. Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. Acta Crystallographica. Section D, Biological Crystallography. 59: 2356-8. PMID 14646118 DOI: 10.1107/S0907444903021784  1
2003 Holyoak T, Wilson MA, Fenn TD, Kettner CA, Petsko GA, Fuller RS, Ringe D. 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry. 42: 6709-18. PMID 12779325 DOI: 10.1021/Bi034434T  1
2001 Holyoak T, Nowak T. Structural investigation of the binding of nucleotide to phosphoenolpyruvate carboxykinase by NMR. Biochemistry. 40: 11037-47. PMID 11551200 DOI: 10.1021/Bi011374N  1
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