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Todd Holyoak, Ph.D. - Publications

Affiliations: 
Biology University of Waterloo, Waterloo, ON, Canada 
 2000 University of Notre Dame, Notre Dame, IN, United States 
Area:
enzyme mechanisms, their regulation and structure and how they are interrelated
Website:
https://uwaterloo.ca/biology/people-profiles/todd-holyoak
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 McLeod MJ, Holyoak T. Biochemical, structural, and kinetic characterization of PP -dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii. Proteins. PMID 37226637 DOI: 10.1002/prot.26513  0.346
2022 Redzic JS, Rahkola J, Tran N, Holyoak T, Lee E, Martín-Galiano AJ, Meyer N, Zheng H, Eisenmesser E. A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Communications Biology. 5: 1190. PMID 36336763 DOI: 10.1038/s42003-022-04173-3  0.31
2012 Johnson TA, Holyoak T. The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry. 51: 9547-59. PMID 23127136 DOI: 10.1021/bi301278t  0.306
2010 Johnson TA, Holyoak T. Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry. 49: 5176-87. PMID 20476774 DOI: 10.1021/bi100399e  0.348
2008 Sullivan SM, Holyoak T. Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proceedings of the National Academy of Sciences of the United States of America. 105: 13829-34. PMID 18772387 DOI: 10.1073/pnas.0805364105  0.316
2007 Sullivan SM, Holyoak T. Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry. 46: 10078-88. PMID 17685635 DOI: 10.1021/bi701038x  0.331
2007 Wheatley JL, Holyoak T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proceedings of the National Academy of Sciences of the United States of America. 104: 6626-31. PMID 17426142 DOI: 10.1073/pnas.0701983104  0.347
2006 Holyoak T, Sullivan SM, Nowak T. Structural insights into the mechanism of PEPCK catalysis. Biochemistry. 45: 8254-63. PMID 16819824 DOI: 10.1021/Bi060269G  0.627
2005 Fenn TD, Holyoak T, Stamper GF, Ringe D. Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase. Biochemistry. 44: 5317-27. PMID 15807525 DOI: 10.1021/Bi047842L  0.567
2004 Holyoak T, Nowak T. pH Dependence of the reaction catalyzed by avian mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 43: 7054-65. PMID 15170343 DOI: 10.1021/Bi049707E  0.563
2004 Holyoak T, Kettner CA, Petsko GA, Fuller RS, Ringe D. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry. 43: 2412-21. PMID 14992578 DOI: 10.1021/Bi035849H  0.659
2003 Holyoak T, Fenn TD, Wilson MA, Moulin AG, Ringe D, Petsko GA. Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. Acta Crystallographica. Section D, Biological Crystallography. 59: 2356-8. PMID 14646118 DOI: 10.1107/S0907444903021784  0.546
2003 Holyoak T, Wilson MA, Fenn TD, Kettner CA, Petsko GA, Fuller RS, Ringe D. 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry. 42: 6709-18. PMID 12779325 DOI: 10.1021/Bi034434T  0.696
2001 Holyoak T, Nowak T. Structural investigation of the binding of nucleotide to phosphoenolpyruvate carboxykinase by NMR. Biochemistry. 40: 11037-47. PMID 11551200 DOI: 10.1021/Bi011374N  0.623
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