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Christal D. Sohl, Ph.D. - Publications

Affiliations: 
2005-2010 Biochemistry Vanderbilt University, Nashville, TN 
 2010-2015 Pharmacology Yale University School of Medicine, New Haven, CT 
 2015- Biochemistry San Diego State University, San Diego, CA, United States 
Area:
Biochemistry
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26/41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sohl CD, Matteo DA, Wells G, Luna L, Upadhye V, Quichocho G, Chambers JM, Miller W, Scott D, Schiffer JM. The Catalytic Features of IDH1 Mutations Can Drive Neomorphic Activity, Phenotype Severity, and Inhibitor Binding The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01939  0.41
2019 Chambers J, Miller W, Quichocho G, Upadhye V, Matteo DA, Bobkov A, Sohl C, Schiffer JM. Water networks and correlated motions in mutant IDH1 are critical for allosteric inhibitor binding and activity. Biochemistry. PMID 31869219 DOI: 10.1021/Acs.Biochem.9B01023  0.428
2019 Kennedy MA, Xu Z, Wu Y, Sohl CD. A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity. Biochemical and Biophysical Research Communications. PMID 30638931 DOI: 10.1016/J.Bbrc.2019.01.020  0.386
2019 Weeks JL, Wells G, Alexander S, Metallo C, Sohl CD. Abstract 4381: Investigating the reversible MDH1 catalytic reaction in squamous non-small cell lung cancer Cancer Research. 79: 4381-4381. DOI: 10.1158/1538-7445.Am2019-4381  0.311
2018 Ryan MR, Sohl CD, Luo B, Anderson KS. The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT. Molecular Cancer Research : McR. PMID 30257990 DOI: 10.1158/1541-7786.Mcr-18-0429  0.559
2018 Matteo DA, Wells GA, Luna LA, Grunseth AJ, Zagnitko O, Scott DA, Hoang A, Luthra A, Swairjo MA, Schiffer JM, Sohl CD. Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. The Biochemical Journal. PMID 30249606 DOI: 10.1042/Bcj20180424  0.432
2017 Matteo DA, Grunseth AJ, Gonzalez ER, Anselmo SL, Kennedy MA, Moman P, Scott DA, Hoang A, Sohl CD. Molecular Mechanisms of Isocitrate Dehydrogenase 1 (IDH1) Mutations Identified in Tumors: The Role of Size and Hydrophobicity at Residue 132 on Catalytic Efficiency. The Journal of Biological Chemistry. PMID 28330869 DOI: 10.1074/Jbc.M117.776179  0.42
2015 Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW. Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proceedings of the National Academy of Sciences of the United States of America. 112: 8596-601. PMID 26124101 DOI: 10.1073/Pnas.1421733112  0.547
2015 Sohl CD, Ray S, Sweasy JB. Pools and Pols: Mechanism of a mutator phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: 5864-5. PMID 25931524 DOI: 10.1073/Pnas.1505169112  0.303
2015 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29. PMID 25686244 DOI: 10.1021/Acschembio.5B00014  0.7
2015 Sohl CD, Ryan M, Luo B, Frey K, Anderson KS. Abstract 2436: Understanding the molecular mechanism of targeted kinase inhibitor resistance mediated by the FGFR1 gatekeeper mutation Cancer Research. 75: 2436-2436. DOI: 10.1158/1538-7445.Am2015-2436  0.691
2015 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular ,mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: The Achilles' heel of targeted therapy Acs Chemical Biology. 10: 1319-1329. DOI: 10.1021/acschembio.5b00014  0.674
2014 Towle-Weicksel JB, Dalal S, Sohl CD, Doublie S, Anderson KS, Sweasy JB. Fluorescence resonance energy transfer studies of DNA polymerase β the critical role of fingers domain movements and a novel non-covalent step During nucleotide selection Journal of Biological Chemistry. 289: 16541-16550. PMID 24764311 DOI: 10.1074/Jbc.M114.561878  0.475
2014 Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS. Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics. Antiviral Research. 106: 1-4. PMID 24632447 DOI: 10.1016/J.Antiviral.2014.03.001  0.516
2013 Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS. Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Human Molecular Genetics. 22: 1074-85. PMID 23208208 DOI: 10.1093/Hmg/Dds509  0.506
2012 Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP. Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. The Journal of Biological Chemistry. 287: 29554-67. PMID 22773874 DOI: 10.1074/Jbc.M112.390047  0.479
2012 Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS. Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase. Molecular Pharmacology. 82: 125-33. PMID 22513406 DOI: 10.1124/Mol.112.078758  0.537
2012 Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity. Antimicrobial Agents and Chemotherapy. 56: 1630-4. PMID 22155823 DOI: 10.1128/Aac.05729-11  0.505
2011 Guengerich FP, Sohl CD, Chowdhury G. Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Archives of Biochemistry and Biophysics. 507: 126-34. PMID 20804723 DOI: 10.1016/J.Abb.2010.08.017  0.627
2010 Sohl CD, Guengerich FP. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. The Journal of Biological Chemistry. 285: 17734-43. PMID 20385561 DOI: 10.1074/Jbc.M110.123711  0.485
2009 Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nature Protocols. 4: 1258-61. PMID 19661996 DOI: 10.1038/Nprot.2009.123  0.475
2009 Sohl CD, Cheng Q, Guengerich FP. Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Nature Protocols. 4: 1252-7. PMID 19661995 DOI: 10.1038/Nprot.2009.122  0.47
2009 Guengerich FP, Martin MV, Sohl CD, Cheng Q. Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Nature Protocols. 4: 1245-51. PMID 19661994 DOI: 10.1038/Nprot.2009.121  0.446
2008 Isin EM, Sohl CD, Eoff RL, Guengerich FP. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Archives of Biochemistry and Biophysics. 473: 69-75. PMID 18328798 DOI: 10.1016/J.Abb.2008.02.033  0.463
2008 Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. The Journal of Biological Chemistry. 283: 7293-308. PMID 18187423 DOI: 10.1074/Jbc.M709783200  0.493
2006 Wu ZL, Sohl CD, Shimada T, Guengerich FP. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Molecular Pharmacology. 69: 2007-14. PMID 16551781 DOI: 10.1124/Mol.106.023648  0.477
Low-probability matches (unlikely to be authored by this person)
2020 Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. The Biochemical Journal. PMID 32729927 DOI: 10.1042/Bcj20200311  0.294
2018 Bernatchez JA, Yang Z, Coste M, Li J, Beck S, Liu Y, Clark AE, Zhu Z, Luna LA, Sohl CD, Purse BW, Li R, Siqueira-Neto JL. Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus. Antimicrobial Agents and Chemotherapy. PMID 30061280 DOI: 10.1128/Aac.00725-18  0.293
2019 Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL. Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells. Viruses. 11. PMID 31010044 DOI: 10.3390/V11040365  0.293
2024 Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, ... Sohl CD, et al. Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms. Biorxiv : the Preprint Server For Biology. PMID 38260668 DOI: 10.1101/2024.01.10.574970  0.286
2016 Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin Y. Erratum: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (8596-8601) DOI: 10.1073/pnas.1421733112) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 26787851 DOI: 10.1073/Pnas.1525460113  0.282
2020 Huynh NH, Hoang A, Sohl CD. Catalytic Characterization of Human Malate Dehydrogenase 1 (MDH1) The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04837  0.281
2024 Sohl C, Mealka M, Sierra N, Matteo D, Albekioni E, Khoury R, Mai T, Conley B, Coleman N, Sabo K, Komives E, Bobkov A, Cooksy A, Silletti S, Schiffer J, et al. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Research Square. PMID 38464189 DOI: 10.21203/rs.3.rs-3889456/v1  0.279
2022 Adam MAA, Sohl CD. Probing altered enzyme activity in the biochemical characterization of cancer. Bioscience Reports. 42. PMID 35048115 DOI: 10.1042/BSR20212002  0.258
2021 Weeks J, Strom AI, Widjaja V, Alexander S, Pucher DK, Sohl CD. Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. Biomolecules. 11. PMID 34065652 DOI: 10.3390/biom11050740  0.255
2004 Sohl CD, Lee J, Alguindigue SS, Khan MA, Richter-Addo GB. Synthesis and solid-state molecular structures of nitrosoalkane complexes of iron porphyrins containing methanol, pyridine, and 1-methylimidazole ligands. Journal of Inorganic Biochemistry. 98: 1238-46. PMID 15219991 DOI: 10.1016/J.Jinorgbio.2004.04.008  0.228
2020 Strom A, Widjaja V, Weeks J, Alexander S, Pucher D, Nguyen TD, Luna L, Matteo DA, Hoang A, Sohl CD. The effect of acetylation on isocitrate dehydrogenase 1 regulation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02372  0.226
2020 Alexander SA, Weeks J, Hoang A, Sohl C. Characterization of Amplified Malate Dehydrogenase 1 (MDH1) in the Context of Squamous Cell Lung Cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04648  0.223
2023 Herrera VE, Charles TP, Scott TG, Prather KY, Nguyen NT, Sohl CD, Thomas LM, Richter-Addo GB. Insights into Nitrosoalkane Binding to Myoglobin Provided by Crystallography of Wild-Type and Distal Pocket Mutant Derivatives. Biochemistry. PMID 37011611 DOI: 10.1021/acs.biochem.2c00725  0.162
2023 Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD. Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry. Biochemistry. PMID 36854124 DOI: 10.1021/acs.biochem.2c00636  0.159
2021 Gross S, Sohl CD. Readying students for careers in industry: A guided inquiry activity to prepare students for success in biotechnology and pharmaceutical industry positions. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. PMID 33569919 DOI: 10.1002/bmb.21491  0.032
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