A Berghuis - Publications

Affiliations: 
McMaster University, Hamilton, ON, Canada 
Area:
Biochemistry

91 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Baettig OM, Shi K, Yachnin BJ, Burk DL, Berghuis AM. Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme. The Febs Journal. PMID 27333541 DOI: 10.1111/Febs.13788  0.36
2016 Avila EE, Rodriguez OI, Marquez JA, Berghuis AM. An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu. Molecular and Biochemical Parasitology. PMID 27234208 DOI: 10.1016/j.molbiopara.2016.05.012  0.36
2016 Caldwell SJ, Huang Y, Berghuis AM. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia. Structure (London, England : 1993). PMID 27161980 DOI: 10.1016/J.Str.2016.04.002  0.36
2016 Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, Zeinieh M, Blanc R, Burk DL, Fahiminiya S, Bareke E, Schüller U, Monoranu CM, Sträter R, Kerl K, ... ... Berghuis AM, et al. Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors. Acta Neuropathologica. PMID 26920151 DOI: 10.1007/S00401-016-1549-X  0.36
2016 Bassenden AV, Rodionov D, Shi K, Berghuis AM. Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design. Acs Chemical Biology. PMID 26900880 DOI: 10.1021/acschembio.5b01070  0.36
2016 Bacot-Davis VR, Bassenden AV, Berghuis AM. Drug-target networks in aminoglycoside resistance: Hierarchy of priority in structural drug design Medchemcomm. 7: 103-113. DOI: 10.1039/c5md00384a  0.36
2015 Brannon JR, Burk DL, Leclerc JM, Thomassin JL, Portt A, Berghuis AM, Gruenheid S, Le Moual H. Inhibition of outer membrane proteases of the omptin family by aprotinin. Infection and Immunity. 83: 2300-11. PMID 25824836 DOI: 10.1128/Iai.00136-15  0.36
2015 Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters. 25: 1117-23. PMID 25630225 DOI: 10.1016/J.Bmcl.2014.12.089  0.36
2015 Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, Lavoie R, Li L, Auger A, Melnyk RA, Grobler JA, Miller MD, Hazuda DJ, Hecht SM, Götte M. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 290: 1474-84. PMID 25355312 DOI: 10.1074/Jbc.M114.614305  0.36
2014 Yachnin BJ, McEvoy MB, MacCuish RJ, Morley KL, Lau PC, Berghuis AM. Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis. Acs Chemical Biology. 9: 2843-51. PMID 25265531 DOI: 10.1021/cb500442e  0.36
2014 Freiburger L, Miletti T, Zhu S, Baettig O, Berghuis A, Auclair K, Mittermaier A. Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. Nature Chemical Biology. 10: 937-42. PMID 25218742 DOI: 10.1038/Nchembio.1626  0.36
2014 Gobeil SM, Clouthier CM, Park J, Gagné D, Berghuis AM, Doucet N, Pelletier JN. Maintenance of native-like protein dynamics may not be required for engineering functional proteins. Chemistry & Biology. 21: 1330-40. PMID 25200606 DOI: 10.1016/J.Chembiol.2014.07.016  0.36
2014 Salem S, Langlais D, Lefebvre F, Bourque G, Bigley V, Haniffa M, Casanova JL, Burk D, Berghuis A, Butler KM, Leahy TR, Hambleton S, Gros P. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation. Blood. 124: 1894-904. PMID 25122610 DOI: 10.1182/Blood-2014-04-570879  0.36
2014 De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. Journal of Medicinal Chemistry. 57: 5764-76. PMID 24911527 DOI: 10.1021/Jm500629E  0.36
2014 Park J, Lin YS, Tsantrizos YS, Berghuis AM. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica. Section F, Structural Biology Communications. 70: 299-304. PMID 24598914 DOI: 10.1107/S2053230X14002106  0.36
2014 Lee MJ, Gravelat FN, Cerone RP, Baptista SD, Campoli PV, Choe SI, Kravtsov I, Vinogradov E, Creuzenet C, Liu H, Berghuis AM, Latgé JP, Filler SG, Fontaine T, Sheppard DC. Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides. The Journal of Biological Chemistry. 289: 1243-56. PMID 24257745 DOI: 10.1074/jbc.M113.522516  0.36
2013 Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, Branton PE. Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication. Plos Pathogens. 9: e1003742. PMID 24244166 DOI: 10.1371/Journal.Ppat.1003742  0.36
2013 Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition. Journal of Medicinal Chemistry. 56: 7939-50. PMID 23998921 DOI: 10.1021/jm400946f  0.36
2013 Shi K, Caldwell SJ, Fong DH, Berghuis AM. Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance. Frontiers in Cellular and Infection Microbiology. 3: 22. PMID 23805415 DOI: 10.3389/Fcimb.2013.00022  0.36
2013 Cheung YH, Gayden T, Campeau PM, LeDuc CA, Russo D, Nguyen VH, Guo J, Qi M, Guan Y, Albrecht S, Moroz B, Eldin KW, Lu JT, Schwartzentruber J, Malkin D, ... Berghuis AM, et al. A recurrent PDGFRB mutation causes familial infantile myofibromatosis. American Journal of Human Genetics. 92: 996-1000. PMID 23731537 DOI: 10.1016/J.Ajhg.2013.04.026  0.36
2013 Mirza IA, Burk DL, Xiong B, Iwaki H, Hasegawa Y, Grosse S, Lau PC, Berghuis AM. Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A. Plos One. 8: e60072. PMID 23555888 DOI: 10.1371/Journal.Pone.0060072  0.36
2012 Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Structural Biology. 12: 32. PMID 23234314 DOI: 10.1186/1472-6807-12-32  0.36
2012 Yachnin BJ, Sprules T, McEvoy MB, Lau PC, Berghuis AM. The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation. Journal of the American Chemical Society. 134: 7788-95. PMID 22506764 DOI: 10.1021/ja211876p  0.36
2012 Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry. 55: 3201-15. PMID 22390415 DOI: 10.1021/Jm201657X  0.36
2012 Shi K, Berghuis AM. Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases. The Journal of Biological Chemistry. 287: 13094-102. PMID 22371504 DOI: 10.1074/jbc.M112.349670  0.36
2012 Caldwell SJ, Berghuis AM. Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure. Antimicrobial Agents and Chemotherapy. 56: 1899-906. PMID 22290965 DOI: 10.1128/Aac.06378-11  0.36
2011 Yachnin BJ, Colin DY, Volpato JP, Ebert M, Pelletier JN, Berghuis AM. Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67: 1316-1322. PMID 22102224 DOI: 10.1107/S1744309111030417  0.36
2011 Shi K, Houston DR, Berghuis AM. Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases. Biochemistry. 50: 6237-44. PMID 21678960 DOI: 10.1021/bi200747f  0.36
2011 Fong DH, Xiong B, Hwang J, Berghuis AM. Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. Plos One. 6: e19589. PMID 21573013 DOI: 10.1371/journal.pone.0019589  0.36
2011 Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, ... ... Berghuis A, et al. IRF8 mutations and human dendritic-cell immunodeficiency. The New England Journal of Medicine. 365: 127-38. PMID 21524210 DOI: 10.1056/Nejmoa1100066  0.36
2011 Freiburger LA, Baettig OM, Sprules T, Berghuis AM, Auclair K, Mittermaier AK. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme. Nature Structural & Molecular Biology. 18: 288-94. PMID 21278754 DOI: 10.1038/Nsmb.1978  0.36
2011 Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, Li S, Berghuis AM, Branton PE. Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein. Journal of Virology. 85: 286-95. PMID 21047956 DOI: 10.1128/Jvi.01381-10  0.36
2010 Gomez MA, Alisaraie L, Shio MT, Berghuis AM, Lebrun C, Gautier-Luneau I, Olivier M. Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate. The Journal of Biological Chemistry. 285: 24620-8. PMID 20519508 DOI: 10.1074/Jbc.M110.107037  0.36
2010 Fong DH, Lemke CT, Hwang J, Xiong B, Berghuis AM. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. The Journal of Biological Chemistry. 285: 9545-55. PMID 20089863 DOI: 10.1074/jbc.M109.038364  0.36
2010 Lau PCK, Leisch H, Yachnin BJ, Mirza IA, Berghuis AM, Iwaki H, Hasegawa Y. Sustained development in baeyer-villiger biooxidation technology Acs Symposium Series. 1043: 343-372. DOI: 10.1021/bk-2010-1043.ch024  0.36
2009 Matte A, Kozlov G, Trempe JF, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M. Preparation and characterization of bacterial protein complexes for structural analysis. Advances in Protein Chemistry and Structural Biology. 76: 1-42. PMID 20663477 DOI: 10.1016/S1876-1623(08)76001-2  0.36
2009 Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance Journal of Biological Chemistry. 284: 20079-20089. PMID 19478082 DOI: 10.1074/Jbc.M109.018010  0.36
2009 Fong DH, Berghuis AM. Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics. Antimicrobial Agents and Chemotherapy. 53: 3049-55. PMID 19433564 DOI: 10.1128/AAC.00062-09  0.36
2009 Mirza IA, Yachnin BJ, Wang S, Grosse S, Bergeron H, Imura A, Iwaki H, Hasegawa Y, Lau PC, Berghuis AM. Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor. Journal of the American Chemical Society. 131: 8848-54. PMID 19385644 DOI: 10.1021/ja9010578  0.36
2009 Rodionov D, Romero PA, Berghuis AM, Herscovics A. Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Protein Expression and Purification. 66: 1-6. PMID 19249370 DOI: 10.1016/J.Pep.2009.02.013  0.36
2008 Xiong B, Burk DL, Shen J, Luo X, Liu H, Shen J, Berghuis AM. The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation. Proteins. 71: 1984-94. PMID 18186484 DOI: 10.1002/Prot.21876  0.36
2008 Miller WL, Matewish MJ, McNally DJ, Ishiyama N, Anderson EM, Brewer D, Brisson JR, Berghuis AM, Lam JS. Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO. The Journal of Biological Chemistry. 283: 3507-18. PMID 18065759 DOI: 10.1074/Jbc.M708894200  0.36
2007 Burk DL, Hwang J, Kwok E, Marrone L, Goodfellow V, Dmitrienko GI, Berghuis AM. Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae. Journal of Molecular Biology. 373: 745-54. PMID 17854830 DOI: 10.1016/J.Jmb.2007.08.044  0.36
2007 Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K. Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Molecular Cell. 27: 474-85. PMID 17679095 DOI: 10.1016/J.Molcel.2007.06.023  0.36
2007 Korczynska M, Mukhtar TA, Wright GD, Berghuis AM. Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase. Proceedings of the National Academy of Sciences of the United States of America. 104: 10388-93. PMID 17563376 DOI: 10.1073/Pnas.0701809104  0.36
2006 Nascimento M, Zhang WW, Ghosh A, Houston DR, Berghuis AM, Olivier M, Matlashewski G. Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence Journal of Biological Chemistry. 281: 36257-36268. PMID 17005559 DOI: 10.1074/Jbc.M606256200  0.36
2006 Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, Wright GD, Auclair K. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. Journal of Medicinal Chemistry. 49: 5273-81. PMID 16913716 DOI: 10.1021/Jm060732N  0.36
2006 Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM. Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity. The Journal of Biological Chemistry. 281: 24489-95. PMID 16651261 DOI: 10.1074/Jbc.M602393200  0.36
2006 Fong DH, Yim VCN, D'Elia MA, Brown ED, Berghuis AM. Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism Biochimica Et Biophysica Acta - Proteins and Proteomics. 1764: 63-69. PMID 16344011 DOI: 10.1016/j.bbapap.2005.10.015  0.36
2005 Lemke CT, Hwang J, Xiong B, Cianciotto NP, Berghuis AM. Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 606-8. PMID 16511108 DOI: 10.1107/S1744309105016301  0.36
2005 Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM. Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of α/β-hydrolases Biochemistry. 44: 15768-15773. PMID 16313180 DOI: 10.1021/Bi051951Y  0.36
2005 Gao F, Yan X, Baettig OM, Berghuis AM, Auclair K. Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases. Angewandte Chemie (International Ed. in English). 44: 6859-62. PMID 16206301 DOI: 10.1002/Anie.200501399  0.36
2005 Burk DL, Xiong B, Breitbach C, Berghuis AM. Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses. Acta Crystallographica. Section D, Biological Crystallography. 61: 1273-9. PMID 16131761 DOI: 10.1107/S0907444905021487  0.36
2005 Christensen KE, Mirza IA, Berghuis AM, MacKenzie RE. Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase Journal of Biological Chemistry. 280: 34316-34323. PMID 16100107 DOI: 10.1074/Jbc.M505210200  0.36
2005 Demendi M, Ishiyama N, Lam JS, Berghuis AM, Creuzenet C. Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP Biochemical Journal. 389: 173-180. PMID 15752069 DOI: 10.1042/BJ20050263  0.36
2005 Bernatchez S, Szymanski CM, Ishiyama N, Li J, Jarrell HC, Lau PC, Berghuis AM, Young NM, Wakarchuk WW. A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni. The Journal of Biological Chemistry. 280: 4792-802. PMID 15509570 DOI: 10.1074/jbc.M407767200  0.36
2005 Fong DH, Burk DL, Berghuis AM. Aminoglycoside kinases and antibiotic resistance Handbook of Experimental Pharmacology. 167: 157-188. DOI: 10.1007/3-540-26670-4-7  0.36
2004 Fortg DH, Berghuis AM. Crystallization and preliminary crystallographic analysis of 3′-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7 Acta Crystallographica Section D: Biological Crystallography. 60: 1897-1899. PMID 15388945 DOI: 10.1107/S0907444904019390  0.36
2004 Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD. New phenolic inhibitors of yeast homoserine dehydrogenase. Bioorganic & Medicinal Chemistry. 12: 3825-30. PMID 15210149 DOI: 10.1016/J.Bmc.2004.05.009  0.36
2004 Ishiyama N, Creuzenet C, Lam JS, Berghuis AM. Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: Substrate specificity in UDP-hexose 4-epimerases Journal of Biological Chemistry. 279: 22635-22642. PMID 15016816 DOI: 10.1074/jbc.M401642200  0.36
2003 Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD. Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Chemistry & Biology. 10: 989-95. PMID 14583265 DOI: 10.1016/J.Chembiol.2003.09.015  0.36
2003 Burk DL, Ghuman N, Wybenga-Groot LE, Berghuis AM. X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members. Protein Science : a Publication of the Protein Society. 12: 426-37. PMID 12592013 DOI: 10.1110/Ps.0233503  0.36
2002 Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED. YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Biochemistry. 41: 11109-17. PMID 12220175 DOI: 10.1021/Bi020355Q  0.36
2002 Burk DL, Berghuis AM. Protein kinase inhibitors and antibiotic resistance. Pharmacology & Therapeutics. 93: 283-92. PMID 12191620 DOI: 10.1016/S0163-7258(02)00197-3  0.36
2002 Thompson PR, Boehr DD, Berghuis AM, Wright GD. Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry. 41: 7001-7. PMID 12033933 DOI: 10.1021/Bi0256680  0.36
2002 Fong DH, Berghuis AM. Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry Embo Journal. 21: 2323-2331. PMID 12006485 DOI: 10.1093/emboj/21.10.2323  0.36
2001 Burk DL, Hon WC, Leung AK, Berghuis AM. Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry. 40: 8756-64. PMID 11467935 DOI: 10.1021/bi010504p  0.36
2001 Yim VCN, Zolli M, Badurina DS, Rossi L, Brown ED, Berghuis AM. Crystallization and preliminary X-ray diffraction studies of glycerol 3-phosphate cytidylyltransferase from Staphylococcus aureus Acta Crystallographica Section D: Biological Crystallography. 57: 918-920. PMID 11375529 DOI: 10.1107/S0907444901005212  0.36
2001 Leung AK, Duewel HS, Honek JF, Berghuis AM. Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose. Biochemistry. 40: 5665-73. PMID 11341831 DOI: 10.1021/Bi0028035  0.36
2000 DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nature Structural Biology. 7: 238-44. PMID 10700284 DOI: 10.1038/73359  0.36
1999 Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD. The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance Journal of Biological Chemistry. 274: 30697-30706. PMID 10521458 DOI: 10.1074/Jbc.274.43.30697  0.36
1999 Wybenga-Groot LE, Draker Ka, Wright GD, Berghuis AM. Crystal structure of an aminoglycoside 6'-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold Structure. 7: 497-507. PMID 10378269 DOI: 10.1016/S0969-2126(99)80066-5  0.36
1998 Wright GD, Berghuis AM, Mobashery S. Aminoglycoside antibiotics: Structures, functions, and resistance Advances in Experimental Medicine and Biology. 456: 27-69. PMID 10549363  0.36
1998 DeLaBarre B, Jacques SL, Pratt CE, Ruth DA, Wright GD, Berghuis AM. Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. Acta Crystallographica. Section D, Biological Crystallography. 54: 413-5. PMID 9761913 DOI: 10.1107/S0907444997011967  0.36
1998 Hunt JF, Mixon MB, Berghuis AM. AUTO_XPL: A Unix shell-script system to sequence X-PLOR refinement runs Journal of Applied Crystallography. 31: 491-495.  0.36
1997 Hon WC, McKay GA, Thompson PR, Sweet RM, Yang DSC, Wright GD, Berghuis AM. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Cell. 89: 887-895. PMID 9200607 DOI: 10.1016/S0092-8674(00)80274-3  0.36
1996 Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR. Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Structure (London, England : 1993). 4: 1277-90. PMID 8939752 DOI: 10.1016/S0969-2126(96)00136-0  0.36
1996 Lett CM, Berghuis AM, Frey HE, Lepock JR, Guillemette JG. The role of a conserved water molecule in the redox-dependent thermal stability of iso-1-cytochrome c. The Journal of Biological Chemistry. 271: 29088-93. PMID 8910563 DOI: 10.1074/jbc.271.46.29088  0.36
1996 Rafferty SP, Guillemette JG, Berghuis AM, Smith M, Brayer GD, Mauk AG. Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity. Biochemistry. 35: 10784-92. PMID 8718869 DOI: 10.1021/bi960430v  0.36
1995 Sutton RB, Davletov BA, Berghuis AM, Südhof TC, Sprang SR. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell. 80: 929-38. PMID 7697723 DOI: 10.1016/0092-8674(95)90296-1  0.36
1995 Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR. Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (New York, N.Y.). 270: 954-60. PMID 7481799 DOI: 10.1126/Science.270.5238.954  0.36
1994 Berghuis AM, Guillemette JG, Smith M, Brayer GD. Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment. Journal of Molecular Biology. 235: 1326-41. PMID 8308895 DOI: 10.1006/Jmbi.1994.1086  0.36
1994 Coleman DE, Lee E, Mixon MB, Linder ME, Berghuis AM, Gilman AG, Sprang SR. Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants of Gi alpha 1 in the GTP and GDP-bound states. Journal of Molecular Biology. 238: 630-4. PMID 8176751 DOI: 10.1006/Jmbi.1994.1320  0.36
1994 Berghuis AM, Guillemette JG, McLendon G, Sherman F, Smith M, Brayer GD. The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrfome c Journal of Molecular Biology. 236: 786-799. PMID 8114094 DOI: 10.1006/Jmbi.1994.1189  0.36
1994 Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (New York, N.Y.). 265: 1405-12. PMID 8073283 DOI: 10.1126/Science.8073283  0.36
1994 Tong Hua, Berghuis AM, Chen Jie, Luo Yaoguang, Guss JM, Freeman HC, Brayer GD. ASIR: An automatic procedure for determining solvent structure in protein crystallography Journal of Applied Crystallography. 27: 421-426. DOI: 10.1107/S0021889893009926  0.36
1993 Burk D, Wang Y, Dombroski D, Berghuis AM, Evans SV, Luo Y, Withers SG, Brayer GD. Isolation, crystallization and preliminary diffraction analyses of human pancreatic alpha-amylase. Journal of Molecular Biology. 230: 1084-5. PMID 8478920 DOI: 10.1006/Jmbi.1993.1221  0.36
1992 Sixma TK, Pronk SE, Kalk KH, van Zanten BA, Berghuis AM, Hol WG. Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature. 355: 561-4. PMID 1741035 DOI: 10.1038/355561A0  0.36
1992 Langen R, Brayer GD, Berghuis AM, McLendon G, Sherman F, Warshel A. Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment. Journal of Molecular Biology. 224: 589-600. PMID 1314900 DOI: 10.1016/0022-2836(92)90546-V  0.36
1992 Berghuis AM, Brayer GD. Oxidation state-dependent conformational changes in cytochrome c Journal of Molecular Biology. 223: 959-976. PMID 1311391 DOI: 10.1016/0022-2836(92)90255-I  0.36
1991 Hickey DR, Berghuis AM, Lafond G, Jaeger JA, Cardillo TS, McLendon D, Das G, Sherman F, Brayer GD, McLendon G. Enhanced thermodynamic stabilities of yeast Iso-1-cytochromes C with amino acid replacements at positions 52 and 102 Journal of Biological Chemistry. 266: 11686-11694. PMID 1646814  0.36
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