| Year |
Citation |
Score |
| 2023 |
Morozova A, Chan SC, Bayle S, Sun L, Grassie D, Iermolaieva A, Kalaga MN, Frydman S, Sansil S, Schönbrunn E, Duckett D, Monastyrskyi A. Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. European Journal of Medicinal Chemistry. 266: 116101. PMID 38232465 DOI: 10.1016/j.ejmech.2023.116101 |
0.306 |
|
| 2023 |
Faber EB, Sun L, Tang J, Roberts E, Ganeshkumar S, Wang N, Rasmussen D, Majumdar A, Hirsch LE, John K, Yang A, Khalid H, Hawkinson JE, Levinson NM, Chennathukuzhi V, et al. Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nature Communications. 14: 3213. PMID 37270540 DOI: 10.1038/s41467-023-38732-x |
0.301 |
|
| 2021 |
Lee JC, Hong KH, Becker A, Tash JS, Schönbrunn E, Georg GI. Tetrahydroindazole inhibitors of CDK2/cyclin complexes. European Journal of Medicinal Chemistry. 214: 113232. PMID 33550184 DOI: 10.1016/j.ejmech.2021.113232 |
0.319 |
|
| 2020 |
Hanna CB, Mudaliar D, John K, Allen CL, Sun L, Hawkinson JE, Schönbrunn E, Georg GI, Jensen JT. Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†. Biology of Reproduction. PMID 32667031 DOI: 10.1093/Biolre/Ioaa097 |
0.391 |
|
| 2020 |
Ycas PD, Zahid H, Chan A, Olson NM, Johnson JA, Talluri SK, Schonbrunn E, Pomerantz WCK. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Organic & Biomolecular Chemistry. PMID 32588860 DOI: 10.1039/D0Ob00506A |
0.372 |
|
| 2020 |
Li Q, Karim RM, Cheng M, Das M, Chen L, Zhang C, Lawrence HR, Daughdrill GW, Schonbrunn E, Ji H, Chen J. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. PMID 32555331 DOI: 10.1038/S41388-020-1344-Y |
0.337 |
|
| 2020 |
Huang Q, Chen L, Schonbrunn E, Chen J. MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling. The Embo Journal. e104410. PMID 32511789 DOI: 10.15252/Embj.2020104410 |
0.351 |
|
| 2020 |
Olson N, Kroc S, Johnson J, Zahid H, Ycas PD, Chan A, Kimbrough J, Kalra P, Schönbrunn E, Pomerantz WCK. NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex. Biochemistry. PMID 32356653 DOI: 10.1021/Acs.Biochem.0C00159 |
0.314 |
|
| 2020 |
Durbin AD, Wimalasena V, Zimmerman MW, Deyao L, Frank ES, Park P, Morita K, Dharia NV, Ross KN, Schonbrunn E, Young RA, Abraham BJ, Stegmaier K, Look AT, Qi J. Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Pr11 |
0.317 |
|
| 2019 |
Liu X, Huang Q, Chen L, Zhang H, Schonbrunn E, Chen J. Tumor-derived CK1α mutations enhance MDMX inhibition of p53. Oncogene. PMID 31462704 DOI: 10.1038/S41388-019-0979-Z |
0.336 |
|
| 2019 |
Tauro M, Ayaz M, Lawrence HR, Lawrence NJ, Shain KH, Schonbrunn E, Lynch CC. Abstract 359: Dual BET/kinase inhibitors as a novel strategy for the treatment of multiple myeloma Cancer Research. 79: 359-359. DOI: 10.1158/1538-7445.Am2019-359 |
0.375 |
|
| 2018 |
Nerlakanti N, Yao J, Nguyen DT, Patel AK, Eroshkin AM, Lawrence HR, Ayaz M, Kuenzi BM, Agarwal N, Chen Y, Gunawan S, Karim RM, Berndt N, Puskas J, Magliocco AM, ... ... Schonbrunn E, et al. Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics. PMID 30242092 DOI: 10.1158/1535-7163.Mct-18-0602 |
0.336 |
|
| 2017 |
Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Schönbrunn E. Structural basis of ALDH1A2 inhibition by irreversible and reversible small molecule inhibitors. Acs Chemical Biology. PMID 29240402 DOI: 10.1021/Acschembio.7B00685 |
0.463 |
|
| 2017 |
Wright G, Golubeva V, Remsing Rix LL, Berndt N, Luo Y, Ward GA, Gray JE, Schönbrunn E, Lawrence HR, Monteiro ANA, Rix U. Dual targeting of WEE1 and PLK1 by AZD1775 elicits single agent cellular anticancer activity. Acs Chemical Biology. PMID 28557434 DOI: 10.1021/Acschembio.7B00147 |
0.362 |
|
| 2016 |
Mishra NK, Urick AK, Ember SW, Schönbrunn E, Pomerantz WC. Correction to Letter: Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain-Ligand Interactions. Acs Chemical Biology. PMID 26836633 DOI: 10.1021/Acschembio.6B00049 |
0.3 |
|
| 2015 |
Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Autoinhibition of MDMX by intramolecular p53 mimicry. Proceedings of the National Academy of Sciences of the United States of America. 112: 4624-9. PMID 25825738 DOI: 10.1073/Pnas.1420833112 |
0.313 |
|
| 2015 |
Lambert QT, Ember SW, Ayaz M, Lawrence HR, Berndt N, Gunawan S, Lawrence NJ, Schönbrunn E, Reuther GW. Single Molecule Dual JAK2-BET Inhibition As an MPN Therapeutic Blood. 126: 2826-2826. DOI: 10.1182/Blood.V126.23.2826.2826 |
0.384 |
|
| 2015 |
Lawrence HR, Luo Y, Gunawan S, Becker A, Ren Y, Schonbrunn E, Wu J, Lawrence NJ. Abstract 3697: Development of a focused non-hydrolyzable phosphopeptide library based on a high affinity SHP2 substrate Cancer Research. 75: 3697-3697. DOI: 10.1158/1538-7445.Am2015-3697 |
0.368 |
|
| 2015 |
Gunawan S, Muhammad A, Ember SWJ, Zhu J, Jacobsen RA, Berndt N, Lambert QT, Reuther GW, Lawrence HR, Schonbrunn E, Lawrence NJ. Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy Cancer Research. 75: 3643-3643. DOI: 10.1158/1538-7445.Am2015-3643 |
0.448 |
|
| 2014 |
Mishra NK, Urick AK, Ember SW, Schönbrunn E, Pomerantz WC. Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions. Acs Chemical Biology. 9: 2755-60. PMID 25290579 DOI: 10.1021/Cb5007344 |
0.334 |
|
| 2014 |
Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Dual aurora a and jak2 kinase blockade effectively suppresses malignant transformation Oncotarget. 5: 2947-2961. PMID 24930769 DOI: 10.18632/Oncotarget.1615 |
0.311 |
|
| 2014 |
Olesen SH, Ingles DJ, Yang Y, Schönbrunn E. Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin. Journal of Basic Microbiology. 54: 322-6. PMID 23686727 DOI: 10.1002/Jobm.201200617 |
0.398 |
|
| 2014 |
Sebti SM, Yang H, Lawrence H, Kazi A, Gervaria H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence N. Abstract 1750: Combined blockade of Aurora A and JAK2 kinase is highly effective at inhibiting malignant transformation Cancer Research. 74: 1750-1750. DOI: 10.1158/1538-7445.Am2014-1750 |
0.321 |
|
| 2013 |
Shigetomi K, Olesen SH, Yang Y, Mitsuhashi S, Schönbrunn E, Ubukata M. MurA as a primary target of tulipalin B and 6-tuliposide B. Bioscience, Biotechnology, and Biochemistry. 77: 2517-9. PMID 24317075 DOI: 10.1271/Bbb.130663 |
0.342 |
|
| 2013 |
Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, et al. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. Journal of Medicinal Chemistry. 56: 3768-82. PMID 23600925 DOI: 10.1021/Jm301234K |
0.675 |
|
| 2012 |
Wu S, Chen L, Becker A, Schonbrunn E, Chen J. Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Molecular and Cellular Biology. 32: 4821-32. PMID 23028042 DOI: 10.1128/Mcb.00851-12 |
0.34 |
|
| 2012 |
Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of Organic Chemistry. 77: 3082-98. PMID 22432895 DOI: 10.1021/Jo202054G |
0.356 |
|
| 2012 |
Zhu JY, Yang Y, Han H, Betzi S, Olesen SH, Marsilio F, Schönbrunn E. Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). The Journal of Biological Chemistry. 287: 12657-67. PMID 22378791 DOI: 10.1074/Jbc.M112.342725 |
0.725 |
|
| 2012 |
Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. The Journal of Biological Chemistry. 287: 10224-35. PMID 22311987 DOI: 10.1074/Jbc.M111.334532 |
0.396 |
|
| 2012 |
Gebhard AW, Nair RR, Emmons M, Jain PR, Becker A, Koomen J, Schonbrunn E, Sullivan DM, McLaughlin ML, Hazlehurst LA. Mti-101 (cyclized HYD1) Binds to CD44 and Induces Necrotic Cell Death in Multiple Myeloma Blood. 120: 4022-4022. DOI: 10.1182/Blood.V120.21.4022.4022 |
0.315 |
|
| 2012 |
Pireddu R, Forinash K, Sun NN, Martin MP, Sung S, Alexander B, Zhu J, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ. Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases Cancer Research. 72: 3904-3904. DOI: 10.1158/1538-7445.Am2012-3904 |
0.348 |
|
| 2012 |
Lawrence HR, Martin MP, Luo Y, Pireddu R, Gevariya H, Ozcan S, Zhu J, Rodriguez M, Elias R, Yang H, Sebti SM, Schonbrunn E, Lawrence NJ. Abstract 3902: Development of Aurora A inhibitors withortho-halophenyl substituted pyrimidines: Unusual potency, SAR and X-ray crystallography studies. Cancer Research. 72: 3902-3902. DOI: 10.1158/1538-7445.Am2012-3902 |
0.343 |
|
| 2012 |
Patel RA, Forinash KD, Pireddu R, Sun Y, Martin MP, Zhu J, Alexander BG, Schonbrunn E, Lawrence NJ, Sebti SM. Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer Cancer Research. 72: 2942-2942. DOI: 10.1158/1538-7445.Am2012-2942 |
0.324 |
|
| 2011 |
Pollegioni L, Schonbrunn E, Siehl D. Molecular basis of glyphosate resistance-different approaches through protein engineering. The Febs Journal. 278: 2753-66. PMID 21668647 DOI: 10.1111/J.1742-4658.2011.08214.X |
0.309 |
|
| 2011 |
Betzi S, Alam R, Martin M, Lubbers DJ, Han H, Jakkaraj SR, Georg GI, Schönbrunn E. Discovery of a potential allosteric ligand binding site in CDK2. Acs Chemical Biology. 6: 492-501. PMID 21291269 DOI: 10.1021/Cb100410M |
0.746 |
|
| 2011 |
Pireddu R, Lawrence HR, Martin MP, Betzi S, Yip R, Yang H, Sun NN, Cheng JQ, Schonbrunn E, Sebti SM, Lawrence NJ. Abstract 3253: Novel oxindole inhibitors of Aurora A kinase: Structure based hit-to-lead approach Cancer Research. 71: 3253-3253. DOI: 10.1158/1538-7445.Am2011-3253 |
0.348 |
|
| 2011 |
Luo Y, Martin M, Kendig R, Pireddu R, Yang H, Betzi S, Books W, Yu H, Schonbrunn E, Lawrence N, Cheng J, Sebti S, Lawrence H. Abstract 3252: Potent Aurora kinase inhibitors based on a pyrimidine scaffold: Synthesis, SAR and X-ray crystallography studies Cancer Research. 71: 3252-3252. DOI: 10.1158/1538-7445.Am2011-3252 |
0.37 |
|
| 2011 |
Alexander BG, Pireddu R, Sun NN, Yu H, Forinash KD, Martin MP, Schonbrunn E, Guida WC, Sebti SM, Lawrence NJ. Abstract 3243: Discovery of novel Rho kinase inhibitors: Hit generation and lead optimization Cancer Research. 71: 3243-3243. DOI: 10.1158/1538-7445.Am2011-3243 |
0.303 |
|
| 2010 |
Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schönbrunn E, Cheng JQ, Sebti SM. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. Cell Death & Differentiation. 17: 1795-1804. PMID 20489726 DOI: 10.1038/Cdd.2010.63 |
0.319 |
|
| 2010 |
Han H, Yang Y, Olesen SH, Becker A, Betzi S, Schönbrunn E. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) . Biochemistry. 49: 4276-82. PMID 20392080 DOI: 10.1021/Bi100365B |
0.769 |
|
| 2010 |
Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. The Journal of Biological Chemistry. 285: 2174-83. PMID 19910468 DOI: 10.1074/Jbc.M109.073056 |
0.412 |
|
| 2010 |
Berndt N, Yang H, Trinczek B, Zhang Z, Wu B, Lawrence NJ, Pellechia M, Schonbrunn E, Cheng JQ, Sebti SM. Abstract 3680: The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane Cancer Research. 70: 3680-3680. DOI: 10.1158/1538-7445.Am10-3680 |
0.352 |
|
| 2009 |
Funke T, Yang Y, Han H, Healy-Fried M, Olesen S, Becker A, Schönbrunn E. Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli. The Journal of Biological Chemistry. 284: 9854-60. PMID 19211556 DOI: 10.1074/Jbc.M809771200 |
0.799 |
|
| 2009 |
Alontaga AY, Rodriguez JC, Schönbrunn E, Becker A, Funke T, Yukl ET, Hayashi T, Stobaugh J, Moënne-Loccoz P, Rivera M. Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin. Biochemistry. 48: 96-109. PMID 19072037 DOI: 10.1021/Bi801860G |
0.766 |
|
| 2008 |
Wang A, Rodríguez JC, Han H, Schönbrunn E, Rivera M. X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa. Biochemistry. 47: 8080-93. PMID 18605699 DOI: 10.1021/Bi8007356 |
0.757 |
|
| 2007 |
Funke T, Healy-Fried ML, Han H, Alberg DG, Bartlett PA, Schönbrunn E. Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues. Biochemistry. 46: 13344-51. PMID 17958399 DOI: 10.1021/Bi701095U |
0.777 |
|
| 2007 |
Wang A, Zeng Y, Han H, Weeratunga S, Morgan BN, Moënne-Loccoz P, Schönbrunn E, Rivera M. Biochemical and structural characterization of Pseudomonas aeruginosa Bfd and FPR: ferredoxin NADP+ reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions. Biochemistry. 46: 12198-211. PMID 17915950 DOI: 10.1021/Bi7013135 |
0.69 |
|
| 2007 |
Healy-Fried ML, Funke T, Priestman MA, Han H, Schönbrunn E. Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase. The Journal of Biological Chemistry. 282: 32949-55. PMID 17855366 DOI: 10.1074/Jbc.M705624200 |
0.773 |
|
| 2006 |
Funke T, Han H, Healy-Fried ML, Fischer M, Schönbrunn E. Molecular basis for the herbicide resistance of Roundup Ready crops. Proceedings of the National Academy of Sciences of the United States of America. 103: 13010-5. PMID 16916934 DOI: 10.1073/Pnas.0603638103 |
0.793 |
|
| 2006 |
Li Q, Hanzlik RP, Weaver RF, Schönbrunn E. Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core. Biochemistry. 45: 701-8. PMID 16411745 DOI: 10.1021/Bi052077B |
0.53 |
|
| 2005 |
Priestman MA, Healy ML, Funke T, Becker A, Schönbrunn E. Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate. Febs Letters. 579: 5773-80. PMID 16225867 DOI: 10.1016/J.Febslet.2005.09.066 |
0.793 |
|
| 2005 |
Priestman MA, Healy ML, Becker A, Alberg DG, Bartlett PA, Lushington GH, Schönbrunn E. Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail. Biochemistry. 44: 3241-8. PMID 15736934 DOI: 10.1021/Bi048198D |
0.817 |
|
| 2005 |
Eschenburg S, Priestman MA, Abdul-Latif FA, Delachaume C, Fassy F, Schönbrunn E. A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). The Journal of Biological Chemistry. 280: 14070-5. PMID 15701635 DOI: 10.1074/Jbc.M414412200 |
0.809 |
|
| 2005 |
Priestman MA, Funke T, Singh IM, Crupper SS, Schönbrunn E. 5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate. Febs Letters. 579: 728-32. PMID 15670836 DOI: 10.1016/J.Febslet.2004.12.057 |
0.782 |
|
| 2005 |
Eschenburg S, Priestman M, Schönbrunn E. Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. The Journal of Biological Chemistry. 280: 3757-63. PMID 15531591 DOI: 10.1074/Jbc.M411325200 |
0.812 |
|
| 2003 |
Eschenburg S, Kabsch W, Healy ML, Schonbrunn E. A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states. The Journal of Biological Chemistry. 278: 49215-22. PMID 13129913 DOI: 10.1074/Jbc.M309741200 |
0.538 |
|
| 2002 |
Eschenburg S, Healy ML, Priestman MA, Lushington GH, Schönbrunn E. How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli. Planta. 216: 129-35. PMID 12430021 DOI: 10.1007/S00425-002-0908-0 |
0.835 |
|
| 2001 |
Schönbrunn E, Eschenburg S, Shuttleworth WA, Schloss JV, Amrhein N, Evans JN, Kabsch W. Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail. Proceedings of the National Academy of Sciences of the United States of America. 98: 1376-80. PMID 11171958 DOI: 10.1073/Pnas.98.4.1376 |
0.587 |
|
| 2000 |
Schönbrunn E, Eschenburg S, Luger K, Kabsch W, Amrhein N. Structural basis for the interaction of the fluorescence probe 8- anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA Proceedings of the National Academy of Sciences of the United States of America. 97: 6345-6349. PMID 10823915 DOI: 10.1073/Pnas.120120397 |
0.387 |
|
| Show low-probability matches. |