Ernst Schonbrunn - Publications

Affiliations: 
University of Kansas, Lawrence, KS, United States 
Area:
Biochemistry

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, ... ... Schonbrunn E, et al. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. The Journal of Biological Chemistry. PMID 29449372 DOI: 10.1074/Jbc.M117.816868  0.32
2015 Allen BK, Mehta S, Ember SW, Schonbrunn E, Ayad N, Schürer SC. Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4. Scientific Reports. 5: 16924. PMID 26596901 DOI: 10.1038/Srep16924  0.4
2015 Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Autoinhibition of MDMX by intramolecular p53 mimicry. Proceedings of the National Academy of Sciences of the United States of America. 112: 4624-9. PMID 25825738 DOI: 10.1073/Pnas.1420833112  0.4
2015 Lawrence HR, Luo Y, Gunawan S, Becker A, Ren Y, Schonbrunn E, Wu J, Lawrence NJ. Abstract 3697: Development of a focused non-hydrolyzable phosphopeptide library based on a high affinity SHP2 substrate Cancer Research. 75: 3697-3697. DOI: 10.1158/1538-7445.Am2015-3697  0.32
2014 Mishra NK, Urick AK, Ember SW, Schönbrunn E, Pomerantz WC. Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions. Acs Chemical Biology. 9: 2755-60. PMID 25290579 DOI: 10.1021/Cb5007344  0.4
2014 Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Dual aurora a and jak2 kinase blockade effectively suppresses malignant transformation Oncotarget. 5: 2947-2961. PMID 24930769 DOI: 10.18632/Oncotarget.1615  0.4
2013 Martin MP, Olesen SH, Georg GI, Schönbrunn E. Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. Acs Chemical Biology. 8: 2360-5. PMID 24007471 DOI: 10.1021/Cb4003283  0.4
2013 Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, et al. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. Journal of Medicinal Chemistry. 56: 3768-82. PMID 23600925 DOI: 10.1021/Jm301234K  0.4
2012 Wu S, Chen L, Becker A, Schonbrunn E, Chen J. Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Molecular and Cellular Biology. 32: 4821-32. PMID 23028042 DOI: 10.1128/Mcb.00851-12  0.32
2012 Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Research. 72: 5025-34. PMID 22846914 DOI: 10.1158/0008-5472.Can-12-0954  0.4
2012 Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ. Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. Journal of Medicinal Chemistry. 55: 7392-416. PMID 22803810 DOI: 10.1021/Jm300334D  0.4
2012 Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of Organic Chemistry. 77: 3082-98. PMID 22432895 DOI: 10.1021/Jo202054G  0.4
2012 Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. Journal of Medicinal Chemistry. 55: 2474-8. PMID 22272748 DOI: 10.1021/Jm201289R  0.4
2011 Pollegioni L, Schonbrunn E, Siehl D. Molecular basis of glyphosate resistance-different approaches through protein engineering. The Febs Journal. 278: 2753-66. PMID 21668647 DOI: 10.1111/J.1742-4658.2011.08214.X  0.4
2011 Betzi S, Alam R, Martin M, Lubbers DJ, Han H, Jakkaraj SR, Georg GI, Schönbrunn E. Discovery of a potential allosteric ligand binding site in CDK2. Acs Chemical Biology. 6: 492-501. PMID 21291269 DOI: 10.1021/Cb100410M  0.4
2010 Han H, Yang Y, Olesen SH, Becker A, Betzi S, Schönbrunn E. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) . Biochemistry. 49: 4276-82. PMID 20392080 DOI: 10.1021/Bi100365B  0.72
2010 Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. The Journal of Biological Chemistry. 285: 2174-83. PMID 19910468 DOI: 10.1074/Jbc.M109.073056  0.4
2009 Funke T, Yang Y, Han H, Healy-Fried M, Olesen S, Becker A, Schönbrunn E. Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli. The Journal of Biological Chemistry. 284: 9854-60. PMID 19211556 DOI: 10.1074/Jbc.M809771200  0.72
2009 Alontaga AY, Rodriguez JC, Schönbrunn E, Becker A, Funke T, Yukl ET, Hayashi T, Stobaugh J, Moënne-Loccoz P, Rivera M. Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin. Biochemistry. 48: 96-109. PMID 19072037 DOI: 10.1021/Bi801860G  0.4
2008 Wang A, Rodríguez JC, Han H, Schönbrunn E, Rivera M. X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa. Biochemistry. 47: 8080-93. PMID 18605699 DOI: 10.1021/Bi8007356  0.72
2007 Funke T, Healy-Fried ML, Han H, Alberg DG, Bartlett PA, Schönbrunn E. Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues. Biochemistry. 46: 13344-51. PMID 17958399 DOI: 10.1021/Bi701095U  0.4
2007 Wang A, Zeng Y, Han H, Weeratunga S, Morgan BN, Moënne-Loccoz P, Schönbrunn E, Rivera M. Biochemical and structural characterization of Pseudomonas aeruginosa Bfd and FPR: ferredoxin NADP+ reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions. Biochemistry. 46: 12198-211. PMID 17915950 DOI: 10.1021/Bi7013135  0.72
2007 Healy-Fried ML, Funke T, Priestman MA, Han H, Schönbrunn E. Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase. The Journal of Biological Chemistry. 282: 32949-55. PMID 17855366 DOI: 10.1074/Jbc.M705624200  0.72
2006 Funke T, Han H, Healy-Fried ML, Fischer M, Schönbrunn E. Molecular basis for the herbicide resistance of Roundup Ready crops. Proceedings of the National Academy of Sciences of the United States of America. 103: 13010-5. PMID 16916934 DOI: 10.1073/Pnas.0603638103  0.72
2006 Li Q, Hanzlik RP, Weaver RF, Schönbrunn E. Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core. Biochemistry. 45: 701-8. PMID 16411745 DOI: 10.1021/Bi052077B  0.4
2005 Priestman MA, Healy ML, Funke T, Becker A, Schönbrunn E. Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate. Febs Letters. 579: 5773-80. PMID 16225867 DOI: 10.1016/J.Febslet.2005.09.066  0.72
2005 Priestman MA, Healy ML, Becker A, Alberg DG, Bartlett PA, Lushington GH, Schönbrunn E. Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail. Biochemistry. 44: 3241-8. PMID 15736934 DOI: 10.1021/Bi048198D  0.4
2005 Eschenburg S, Priestman MA, Abdul-Latif FA, Delachaume C, Fassy F, Schönbrunn E. A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). The Journal of Biological Chemistry. 280: 14070-5. PMID 15701635 DOI: 10.1074/Jbc.M414412200  0.72
2005 Priestman MA, Funke T, Singh IM, Crupper SS, Schönbrunn E. 5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate. Febs Letters. 579: 728-32. PMID 15670836 DOI: 10.1016/J.Febslet.2004.12.057  0.72
2005 Eschenburg S, Priestman M, Schönbrunn E. Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. The Journal of Biological Chemistry. 280: 3757-63. PMID 15531591 DOI: 10.1074/Jbc.M411325200  0.48
2003 Eschenburg S, Kabsch W, Healy ML, Schonbrunn E. A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states. The Journal of Biological Chemistry. 278: 49215-22. PMID 13129913 DOI: 10.1074/Jbc.M309741200  0.48
2002 Eschenburg S, Healy ML, Priestman MA, Lushington GH, Schönbrunn E. How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli. Planta. 216: 129-35. PMID 12430021 DOI: 10.1007/S00425-002-0908-0  0.72
2001 Schönbrunn E, Eschenburg S, Shuttleworth WA, Schloss JV, Amrhein N, Evans JN, Kabsch W. Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail. Proceedings of the National Academy of Sciences of the United States of America. 98: 1376-80. PMID 11171958 DOI: 10.1073/Pnas.98.4.1376  0.48
2000 Schönbrunn E, Eschenburg S, Luger K, Kabsch W, Amrhein N. Structural basis for the interaction of the fluorescence probe 8- anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA Proceedings of the National Academy of Sciences of the United States of America. 97: 6345-6349. PMID 10823915 DOI: 10.1073/Pnas.120120397  0.4
1997 Kozielski F, Schönbrunn E, Sack S, Müller J, Brady ST, Mandelkow E. Crystallization and preliminary X-ray analysis of the single-headed and double-headed motor protein kinesin. Journal of Structural Biology. 119: 28-34. PMID 9216086 DOI: 10.1006/Jsbi.1997.3872  0.4
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