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Johan Paulsson - Publications

Affiliations: 
Engineering and Applied Sciences Harvard University, Cambridge, MA, United States 
Area:
Biomedical Engineering, Molecular Biology, Microbiology Biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bakshi S, Leoncini E, Baker C, Cañas-Duarte SJ, Okumus B, Paulsson J. Tracking bacterial lineages in complex and dynamic environments with applications for growth control and persistence. Nature Microbiology. 6: 783-791. PMID 34017106 DOI: 10.1038/s41564-021-00900-4  0.554
2021 Manuse S, Shan Y, Canas-Duarte SJ, Bakshi S, Sun WS, Mori H, Paulsson J, Lewis K. Bacterial persisters are a stochastically formed subpopulation of low-energy cells. Plos Biology. 19: e3001194. PMID 33872303 DOI: 10.1371/journal.pbio.3001194  0.544
2021 Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Author Correction: Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nature Communications. 12: 1818. PMID 33727556 DOI: 10.1038/s41467-021-22149-5  0.543
2020 Basan M, Honda T, Christodoulou D, Hörl M, Chang YF, Leoncini E, Mukherjee A, Okano H, Taylor BR, Silverman JM, Sanchez C, Williamson JR, Paulsson J, Hwa T, Sauer U. A universal trade-off between growth and lag in fluctuating environments. Nature. PMID 32669712 DOI: 10.1038/S41586-020-2505-4  0.335
2020 Kuo J, Yuan R, Sánchez C, Paulsson J, Silver PA. Toward a translationally independent RNA-based synthetic oscillator using deactivated CRISPR-Cas. Nucleic Acids Research. PMID 32609820 DOI: 10.1093/Nar/Gkaa557  0.301
2019 Luro S, Potvin-Trottier L, Okumus B, Paulsson J. Isolating live cells after high-throughput, long-term, time-lapse microscopy. Nature Methods. PMID 31768062 DOI: 10.1038/S41592-019-0620-7  0.392
2019 Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nature Communications. 10: 4665. PMID 31604953 DOI: 10.1038/S41467-019-12638-Z  0.582
2019 Lord ND, Norman TM, Yuan R, Bakshi S, Losick R, Paulsson J. Stochastic antagonism between two proteins governs a bacterial cell fate switch. Science (New York, N.Y.). 366: 116-120. PMID 31604312 DOI: 10.1126/Science.Aaw4506  0.629
2019 Lepore A, Taylor H, Landgraf D, Okumus B, Jaramillo-Riveri S, McLaren L, Bakshi S, Paulsson J, Karoui ME. Quantification of very low-abundant proteins in bacteria using the HaloTag and epi-fluorescence microscopy. Scientific Reports. 9: 7902. PMID 31133640 DOI: 10.1038/S41598-019-44278-0  0.731
2018 Potvin-Trottier L, Luro S, Paulsson J. Microfluidics and single-cell microscopy to study stochastic processes in bacteria. Current Opinion in Microbiology. 43: 186-192. PMID 29494845 DOI: 10.1016/J.Mib.2017.12.004  0.472
2018 Okumus B, Baker CJ, Arias-Castro JC, Lai GC, Leoncini E, Bakshi S, Luro S, Landgraf D, Paulsson J. Single-cell microscopy of suspension cultures using a microfluidics-assisted cell screening platform. Nature Protocols. 13: 170-194. PMID 29266097 DOI: 10.1038/Nprot.2017.127  0.74
2017 Russell JR, Cabeen MT, Wiggins PA, Paulsson J, Losick R. Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. The Embo Journal. PMID 28838935 DOI: 10.15252/Embj.201796988  0.323
2017 Cabeen MT, Russell JR, Paulsson J, Losick R. Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. Plos Genetics. 13: e1006901. PMID 28727759 DOI: 10.1371/Journal.Pgen.1006901  0.339
2017 Taheri-Araghi S, Bradde S, Sauls JT, Hill NS, Levin PA, Paulsson J, Vergassola M, Jun S. Cell-Size Control and Homeostasis in Bacteria. Current Biology : Cb. 27: 1392. PMID 28486111 DOI: 10.1016/J.Cub.2017.04.028  0.356
2016 Wayne G, Graves A, Hassabis D, Saha S, Weber CA, Hyman AA, Juelicher F, Stroud DA, Ryan MT, Potvin-Trottier L, Paulsson J, Geiler-Samerotte KA, Siegal ML, Uhlen M, Edfors F, et al. Principles of Systems Biology, No. 11 Cell Systems. 3: 406-410. PMID 27883884 DOI: 10.1016/J.Cels.2016.11.010  0.316
2016 Potvin-Trottier L, Lord ND, Vinnicombe G, Paulsson J. Synchronous long-term oscillations in a synthetic gene circuit. Nature. PMID 27732583 DOI: 10.1038/Nature19841  0.355
2016 Okumus B, Landgraf D, Lai GC, Bakshi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Corrigendum: Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nature Communications. 7: 12130. PMID 27338979 DOI: 10.1038/Ncomms12130  0.728
2016 Okumus B, Landgraf D, Lai GC, Bakhsi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nature Communications. 7: 11641. PMID 27189321 DOI: 10.1038/Ncomms11641  0.755
2016 Hilfinger A, Norman TM, Paulsson J. Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems. Cell Systems. 2: 251-9. PMID 27135537 DOI: 10.1016/J.Cels.2016.04.002  0.332
2016 Uphoff S, Lord ND, Okumus B, Potvin-Trottier L, Sherratt DJ, Paulsson J. Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation. Science (New York, N.Y.). 351: 1094-7. PMID 26941321 DOI: 10.1126/Science.Aac9786  0.401
2016 Hilfinger A, Norman TM, Vinnicombe G, Paulsson J. Constraints on Fluctuations in Sparsely Characterized Biological Systems. Physical Review Letters. 116: 058101. PMID 26894735 DOI: 10.1103/Physrevlett.116.058101  0.353
2016 Ke N, Landgraf D, Paulsson J, Berkmen M. Visualization of periplasmic and cytoplasmic proteins with a self-labeling protein tag. Journal of Bacteriology. PMID 26787765 DOI: 10.1128/Jb.00864-15  0.68
2016 Jajoo R, Jung Y, Huh D, Viana MP, Rafelski SM, Springer M, Paulsson J. Accurate concentration control of mitochondria and nucleoids. Science (New York, N.Y.). 351: 169-72. PMID 26744405 DOI: 10.1126/Science.Aaa8714  0.578
2015 Norman TM, Lord ND, Paulsson J, Losick R. Stochastic Switching of Cell Fate in Microbes. Annual Review of Microbiology. PMID 26332088 DOI: 10.1146/Annurev-Micro-091213-112852  0.379
2015 Hilfinger A, Paulsson J. Systems biology: Defiant daughters and coordinated cousins. Nature. 519: 422-3. PMID 25762142 DOI: 10.1038/Nature14210  0.372
2015 Taheri-Araghi S, Bradde S, Sauls JT, Hill NS, Levin PA, Paulsson J, Vergassola M, Jun S. Cell-size control and homeostasis in bacteria. Current Biology : Cb. 25: 385-91. PMID 25544609 DOI: 10.1016/J.Cub.2014.12.009  0.416
2013 Norman TM, Lord ND, Paulsson J, Losick R. Memory and modularity in cell-fate decision making. Nature. 503: 481-6. PMID 24256735 DOI: 10.1038/Nature12804  0.363
2013 Lau BT, Malkus P, Paulsson J. New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid. 70: 353-61. PMID 24042048 DOI: 10.1016/J.Plasmid.2013.07.007  0.341
2013 Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R. Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nature Protocols. 8: 555-67. PMID 23429717 DOI: 10.1038/Nprot.Nprot.2013.021  0.58
2012 Hilfinger A, Chen M, Paulsson J. Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Physical Review Letters. 109: 248104. PMID 23368387 DOI: 10.1103/Physrevlett.109.248104  0.316
2012 Landgraf D, Okumus B, Chien P, Baker TA, Paulsson J. Segregation of molecules at cell division reveals native protein localization. Nature Methods. 9: 480-2. PMID 22484850 DOI: 10.1038/Nmeth.1955  0.697
2012 Tal S, Paulsson J. Evaluating quantitative methods for measuring plasmid copy numbers in single cells Plasmid. 67: 167-173. PMID 22305922 DOI: 10.1016/J.Plasmid.2012.01.004  0.456
2011 Huh D, Paulsson J. Random partitioning of molecules at cell division. Proceedings of the National Academy of Sciences of the United States of America. 108: 15004-9. PMID 21873252 DOI: 10.1073/Pnas.1013171108  0.604
2011 Hilfinger A, Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proceedings of the National Academy of Sciences of the United States of America. 108: 12167-72. PMID 21730172 DOI: 10.1073/Pnas.1018832108  0.34
2011 Huh D, Paulsson J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nature Genetics. 43: 95-100. PMID 21186354 DOI: 10.1038/Ng.729  0.628
2010 Lestas I, Vinnicombe G, Paulsson J. Fundamental limits on the suppression of molecular fluctuations. Nature. 467: 174-8. PMID 20829788 DOI: 10.1038/Nature09333  0.389
2009 Tal S, Paulsson J. Cells' senses and sensibilities Nature Chemical Biology. 5: 705-706. DOI: 10.1038/Nchembio.229  0.387
2008 Pedraza JM, Paulsson J. Effects of molecular memory and bursting on fluctuations in gene expression. Science (New York, N.Y.). 319: 339-43. PMID 18202292 DOI: 10.1126/Science.1144331  0.396
2008 Lestas I, Paulsson J, Ross NE, Vinnicombe G. Noise in Gene Regulatory Networks Ieee Transactions On Automatic Control. 53: 189-200. DOI: 10.1109/Tac.2007.911347  0.316
2006 Rando OJ, Paulsson J. Noisy silencing of chromatin. Developmental Cell. 11: 134-6. PMID 16890152 DOI: 10.1016/J.Devcel.2006.07.012  0.378
2006 Paulsson J, Chattoraj DK. Origin inactivation in bacterial DNA replication control. Molecular Microbiology. 61: 9-15. PMID 16824091 DOI: 10.1111/J.1365-2958.2006.05229.X  0.36
2006 Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, Pilpel Y, Barkai N. Noise in protein expression scales with natural protein abundance. Nature Genetics. 38: 636-43. PMID 16715097 DOI: 10.1038/Ng1807  0.589
2005 Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell. 123: 1025-36. PMID 16360033 DOI: 10.1016/J.Cell.2005.09.031  0.45
2005 Paulsson J. Prime movers of noisy gene expression. Nature Genetics. 37: 925-6. PMID 16132049 DOI: 10.1038/Ng0905-925  0.325
2005 Das N, Valjavec-Gratian M, Basuray AN, Fekete RA, Papp PP, Paulsson J, Chattoraj DK. Multiple homeostatic mechanisms in the control of P1 plasmid replication. Proceedings of the National Academy of Sciences of the United States of America. 102: 2856-61. PMID 15708977 DOI: 10.1073/Pnas.0409790102  0.352
2005 Paulsson J. Models of stochastic gene expression Physics of Life Reviews. 2: 157-175. DOI: 10.1016/J.Plrev.2005.03.003  0.35
2004 Paulsson J. Summing up the noise in gene networks. Nature. 427: 415-8. PMID 14749823 DOI: 10.1038/Nature02257  0.368
2004 Olsson JA, Paulsson J, Nordström K. Effect of the CopB auxiliary replication control system on stability of maintenance of Par(+) plasmid R1. Journal of Bacteriology. 186: 207-11. PMID 14679240 DOI: 10.1128/Jb.186.1.207-211.2004  0.381
2002 Park K, Han E, Paulsson J, Chattoraj DK. Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number. The Embo Journal. 20: 7323-32. PMID 11743008 DOI: 10.1093/Emboj/20.24.7323  0.302
2001 Berg OG, Paulsson J, Ehrenberg M. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing. Biophysical Journal. 79: 2944-53. PMID 11106602 DOI: 10.1016/S0006-3495(00)76531-3  0.357
2000 Paulsson J, Ehrenberg M. Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. Physical Review Letters. 84: 5447-50. PMID 10990965 DOI: 10.1103/Physrevlett.84.5447  0.319
2000 Berg OG, Paulsson J, Ehrenberg M. Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated. Biophysical Journal. 79: 1228-36. PMID 10968987 DOI: 10.1016/S0006-3495(00)76377-6  0.41
2000 Paulsson J, Berg OG, Ehrenberg M. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proceedings of the National Academy of Sciences of the United States of America. 97: 7148-53. PMID 10852944 DOI: 10.1073/Pnas.110057697  0.339
2000 Paulsson J, Ehrenberg M. Molecular clocks reduce plasmid loss rates: the R1 case. Journal of Molecular Biology. 297: 179-92. PMID 10704315 DOI: 10.1006/Jmbi.2000.3526  0.388
1998 Paulsson J, Nordström K, Ehrenberg M. Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates. Plasmid. 39: 215-34. PMID 9571138 DOI: 10.1006/Plas.1998.1338  0.358
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