Sadanandan E. Velu - Publications

Affiliations: 
Chemistry University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Pharmaceutical Chemistry, Organic Chemistry

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aburjania Z, Whitt JD, Jang S, Nadkarni DH, Chen H, Rose JB, Velu SE, Jaskula-Sztul R. Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells. Molecules (Basel, Switzerland). 25. PMID 33114525 DOI: 10.3390/molecules25214940  0.48
2019 Cowan J, Shadab M, Nadkarni DH, Kc K, Velu SE, Yusuf N. A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells. Marine Drugs. 17. PMID 31357586 DOI: 10.3390/md17080443  0.48
2019 Wang W, Cheng J, Qin JJ, Hu B, Li X, Nijampatnam B, Velu SE, Fan J, Yang XR, Zhang R. MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53. Cancer Letters. 114429. PMID 31181320 DOI: 10.1016/j.canlet.2019.114429  0.32
2018 Wang W, Qin JJ, Voruganti S, Nijampatnam B, Velu SE, Ruan KH, Hu M, Zhou J, Zhang R. Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. Cancer Research. PMID 30217928 DOI: 10.1158/0008-5472.CAN-17-3939  0.32
2018 Nijampatnam B, Zhang H, Cai X, Michalek SM, Wu H, Velu SE. Inhibition of Biofilms by the Natural Stilbene Piceatannol Through the Inhibition of Glucosyltransferases. Acs Omega. 3: 8378-8385. PMID 30087944 DOI: 10.1021/acsomega.8b00367  0.32
2017 Zhang Q, Nijampatnam B, Hua Z, Nguyen T, Zou J, Cai X, Michalek SM, Velu SE, Wu H. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Scientific Reports. 7: 5974. PMID 28729722 DOI: 10.1038/s41598-017-06168-1  0.32
2017 Xue B, Wang W, Qin JJ, Nijampatnam B, Murugesan S, Kozlovskaya V, Zhang R, Velu SE, Kharlampieva E. Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes. Acta Biomaterialia. PMID 28583901 DOI: 10.1016/j.actbio.2017.06.004  0.48
2016 Nijampatnam B, Casals L, Zheng R, Wu H, Velu SE. Hydroxychalcone inhibitors of Streptococcus mutans glucosyl transferases and biofilms as potential anticaries agents. Bioorganic & Medicinal Chemistry Letters. PMID 27371109 DOI: 10.1016/j.bmcl.2016.06.033  0.48
2016 Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels. Redox Biology. 8: 136-148. PMID 26774751 DOI: 10.1016/j.redox.2016.01.002  0.32
2016 Xu S, Nijampatnam B, Dutta S, Velu SE. Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation. Marine Drugs. 14. PMID 26771620 DOI: 10.3390/md14010017  0.48
2016 Wang W, Nijampatnam B, Velu SE, Zhang R. Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy Frontiers of Chemical Science and Engineering. 10: 1-15. DOI: 10.1007/s11705-016-1562-6  0.48
2015 Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, et al. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. The Journal of Biological Chemistry. PMID 26627831 DOI: 10.1074/jbc.M115.704809  0.48
2015 Nijampatnam B, Dutta S, Velu SE. Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin. Chinese Journal of Natural Medicines. 13: 561-77. PMID 26253489 DOI: 10.1016/S1875-5364(15)30052-2  0.48
2015 Yu JX, Voruganti S, Li DD, Qin JJ, Nag S, Xu S, Velu SE, Wang W, Zhang R. Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats. Chinese Journal of Natural Medicines. 13: 554-60. PMID 26233847 DOI: 10.1016/S1875-5364(15)30051-0  0.48
2015 Zhang Q, Nguyen T, McMichael M, Velu SE, Zou J, Zhou X, Wu H. New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans. International Journal of Antimicrobial Agents. 46: 174-82. PMID 26022931 DOI: 10.1016/j.ijantimicag.2015.03.015  0.48
2015 Singh T, Gupta NA, Xu S, Prasad R, Velu SE, Katiyar SK. Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor. Oncotarget. PMID 26020804  0.48
2015 Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms. Plos One. 10: e0120460. PMID 25785718 DOI: 10.1371/journal.pone.0120460  0.48
2014 Nijampatnam B, Nadkarni DH, Wu H, Velu SE. Antibacterial and Antibiofilm Activities of Makaluvamine Analogs. Microorganisms. 2: 128-139. PMID 25767719 DOI: 10.3390/microorganisms2030128  0.48
2014 Xu S, Nguyen T, Pomilio I, Vitale MC, Velu SE. Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione. Tetrahedron. 70: 5928-5933. PMID 25663720 DOI: 10.1016/j.tet.2014.06.021  0.48
2013 Nguyen T, Nadkarni D, Dutta S, Xu S, Kim S, Murugesan S, Velu S. Synthesis of Pyrroloquinones via a CAN Mediated Oxidative Free Radical Reaction of 1,3-Dicarbonyl Compounds with Aminoquinones. Journal of Chemistry. 2013. PMID 25705550 DOI: 10.1155/2013/262580  0.48
2013 Nadkarni DH, Murugesan S, Velu SE. Total synthesis of zyzzyanones A-D. Tetrahedron. 69: 4105-4113. PMID 23956468 DOI: 10.1016/j.tet.2013.03.052  0.48
2013 Chen D, Wang W, Qin JJ, Wang MH, Murugesan S, Nadkarni DH, Velu SE, Wang H, Zhang R. Identification of the ZAK-MKK4-JNK-TGFβ signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ. Current Cancer Drug Targets. 13: 651-60. PMID 23607596 DOI: 10.2174/15680096113139990040  0.48
2013 Keeling KM, Wang D, Dai Y, Murugesan S, Chenna B, Clark J, Belakhov V, Kandasamy J, Velu SE, Baasov T, Bedwell DM. Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. Plos One. 8: e60478. PMID 23593225 DOI: 10.1371/journal.pone.0060478  0.48
2013 Jarboe JS, Dutta S, Velu SE, Willey CD. Mini-review: bmx kinase inhibitors for cancer therapy. Recent Patents On Anti-Cancer Drug Discovery. 8: 228-38. PMID 23198769 DOI: 10.2174/15748928113089990043  0.48
2012 Zhang X, Xu H, Zhang X, Voruganti S, Murugesan S, Nadkarni DH, Velu SE, Wang MH, Wang W, Zhang R. Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog. Marine Drugs. 10: 1138-55. PMID 22822362 DOI: 10.3390/md10051138  0.48
2012 Nag S, Nadkarni DH, Qin JJ, Voruganti S, Nguyen T, Xu S, Wang W, Wang H, Velu SE, Zhang R. Anticancer activity and molecular mechanisms of action of makaluvamines and analogues Molecular and Cellular Pharmacology. 4: 69-81. DOI: 10.4255/mcpharmacol.12.07  0.48
2011 Chen T, Xu Y, Guo H, Liu Y, Hu P, Yang X, Li X, Ge S, Velu SE, Nadkarni DH, Wang W, Zhang R, Wang H. Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action. Plos One. 6: e20729. PMID 21673964 DOI: 10.1371/journal.pone.0020729  0.48
2011 Anderson JT, Zeng M, Li Q, Stapley R, Moore DR, Chenna B, Fineberg N, Zmijewski J, Eltoum IE, Siegal GP, Gaggar A, Barnes S, Velu SE, Thannickal VJ, Abraham E, et al. Elevated levels of NO are localized to distal airways in asthma. Free Radical Biology & Medicine. 50: 1679-88. PMID 21419218 DOI: 10.1016/j.freeradbiomed.2011.03.015  0.48
2011 Li H, Ezell SJ, Zhang X, Wang W, Xu H, Rayburn ER, Zhang X, Gurpinar E, Yang X, Sommers CI, Velu SE, Zhang R. Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice. Biomedical Chromatography : Bmc. 25: 628-34. PMID 20845374 DOI: 10.1002/bmc.1498  0.48
2010 Ezell SJ, Li H, Xu H, Zhang X, Gurpinar E, Zhang X, Rayburn ER, Sommers CI, Yang X, Velu SE, Wang W, Zhang R. Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent. Marine Drugs. 8: 2129-41. PMID 20714427 DOI: 10.3390/md8072129  0.48
2010 Chenna BC, King JR, Shinkre BA, Glover AL, Lucius AL, Velu SE. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. European Journal of Medicinal Chemistry. 45: 3752-61. PMID 20541848 DOI: 10.1016/j.ejmech.2010.05.024  0.48
2010 Schormann N, Velu SE, Murugesan S, Senkovich O, Walker K, Chenna BC, Shinkre B, Desai A, Chattopadhyay D. Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorganic & Medicinal Chemistry. 18: 4056-66. PMID 20452776 DOI: 10.1016/j.bmc.2010.04.020  0.48
2010 Wang W, Rayburn ER, Velu SE, Chen D, Nadkarni DH, Murugesan S, Chen D, Zhang R. A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action. Breast Cancer Research and Treatment. 123: 321-31. PMID 19936915 DOI: 10.1007/s10549-009-0638-0  0.48
2010 Wang F, Ezell SJ, Zhang Y, Wang W, Rayburn ER, Nadkarni DH, Murugesan S, Velu SE, Zhang R. FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer. Investigational New Drugs. 28: 234-41. PMID 19274441 DOI: 10.1007/s10637-009-9232-x  0.48
2009 Murugesan S, Nadkarni DH, Velu SE. A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids. Tetrahedron Letters. 50: 3074-3076. PMID 25698845 DOI: 10.1016/j.tetlet.2009.04.021  0.48
2009 Wang W, Rayburn ER, Velu SE, Nadkarni DH, Murugesan S, Zhang R. In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3511-8. PMID 19451594 DOI: 10.1158/1078-0432.CCR-08-2689  0.48
2009 Nadkarni DH, Wang F, Wang W, Rayburn ER, Ezell SJ, Murugesan S, Velu SE, Zhang R. Synthesis and in vitro anti-lung cancer activity of novel 1, 3, 4, 8-tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogs. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 5: 227-36. PMID 19442212 DOI: 10.2174/157340609788185873  0.48
2009 Kang S, Mou L, Lanman J, Velu S, Brouillette WJ, Prevelige PE. Synthesis of biotin-tagged chemical cross-linkers and their applications for mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 23: 1719-26. PMID 19412923 DOI: 10.1002/rcm.4066  0.48
2009 Lee YJ, King JR, Chenna BC, Owens SB, Freeman JL, Gray GM, Velu SE. Synthesis and the crystal structure of (E)-2-(7-(3-(Thiophen-2-yl) acrylamido)-2,3-dihydro-5-oxobenzo[e][1,4]oxazepin-1(5H)-yl)ethyl acetate Journal of Chemical Crystallography. 39: 902-907. DOI: 10.1007/s10870-009-9588-y  0.48
2008 Shinkre BA, Raisch KP, Fan L, Velu SE. Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines. Bioorganic & Medicinal Chemistry. 16: 2541-9. PMID 18093835 DOI: 10.1016/j.bmc.2007.11.051  0.48
2008 Chenna BC, Shinkre BA, King JR, Lucius AL, Narayana SV, Velu SE. Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A. Bioorganic & Medicinal Chemistry Letters. 18: 380-5. PMID 18023345 DOI: 10.1016/j.bmcl.2007.10.051  0.48
2008 Patel SP, Nadkarni DH, Murugesan S, King JR, Velu SE. Azide-mediated detosylation of N-tosylpyrroloiminoquinones and N-tosylindole-4,7-quinones Synlett. 2864-2868. DOI: 10.1055/s-0028-1083570  0.48
2008 Shinkre BA, Nadkarni DH, Owens SB, Gray GM, Velu SE. Synthesis of E isomer and crystal structures of E and Z isomers of 3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile Journal of Chemical Crystallography. 38: 205-209. DOI: 10.1007/s10870-007-9290-x  0.48
2008 Chenna BC, Shinkre BA, Patel S, Owens SB, Gray GM, Velu SE. Synthesis, separation and crystal structures of E and Z isomers of 3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylic acid Journal of Chemical Crystallography. 38: 189-194. DOI: 10.1007/s10870-007-9288-4  0.48
2007 Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/jm061349l  0.48
2007 Shinkre BA, Raisch KP, Fan L, Velu SE. Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity. Bioorganic & Medicinal Chemistry Letters. 17: 2890-3. PMID 17368022 DOI: 10.1016/j.bmcl.2007.02.065  0.48
2007 Shinkre BA, Velu SE. Total synthesis of secobatzelline B Synthetic Communications. 37: 2399-2409. DOI: 10.1080/00397910701410954  0.48
2005 Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/cc050063j  0.48
2003 Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/jm030003x  0.48
2003 Brouillette WJ, Bajpai SN, Ali SM, Velu SE, Atigadda VR, Lommer BS, Finley JB, Luo M, Air GM. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents. Bioorganic & Medicinal Chemistry. 11: 2739-49. PMID 12788348 DOI: 10.1016/S0968-0896(03)00271-2  0.48
2000 Dieter RK, Lu K, Velu SE. Conjugate addition reactions of alpha-aminoalkylcuprates with alpha, beta-alkenyl-, alpha,beta-alkynyl-, alpha,beta-beta,gamma-allenyl-, and alpha,beta-gamma,delta-dienyl carboxylic acid derivatives, nitriles, and sulfoxides. The Journal of Organic Chemistry. 65: 8715-24. PMID 11112594 DOI: 10.1021/jo0056038  0.48
1997 Dieter RK, Velu SE. (α-Aminoalkyl)cuprates Prepared from Soluble Copper(I) Salts: Conjugate Additions to α,βUnsaturated Carboxylic Acid Derivatives Journal of Organic Chemistry. 62: 3798-3799.  0.48
1997 Dieter RK, Velu SE, Nice LE. Regioselective Control in the Reactions of α-Aminoalkylcuprates with Allylic Substrates Synlett. 1997: 1114-1116.  0.48
1996 Dieter RK, Nice LE, Velu SE. Oxidation of α,β-enones and alkenes with oxone and sodium halides: A convenient laboratory preparation of chlorine and bromine Tetrahedron Letters. 37: 2377-2380. DOI: 10.1016/0040-4039(96)00295-X  0.48
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