Rachel J. Perry, Ph.D. - Publications

Affiliations: 
2013 Yale University, New Haven, CT 
Area:
Physiology Biology, Endocrinology Biology, Biochemistry

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lyu K, Zhang D, Song JD, Li X, Perry RJ, Samuel VT, Shulman GI. Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation. Jci Insight. PMID 33411692 DOI: 10.1172/jci.insight.139946  0.8
2021 He F, Huang Y, Song Z, Zhou HJ, Zhang H, Perry RJ, Shulman GI, Min W. Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance. The Journal of Experimental Medicine. 218. PMID 33315085 DOI: 10.1084/jem.20201416  0.8
2020 Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G, Davis RJ. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes & Development. PMID 33334822 DOI: 10.1101/gad.344556.120  0.8
2020 Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, Perry RJ, Shulman GI. Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 33293421 DOI: 10.1073/pnas.1922169117  0.8
2020 Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, et al. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. PMID 33058756 DOI: 10.1016/j.cell.2020.09.017  0.8
2020 Song JD, Alves TC, Befroy DE, Perry RJ, Mason GF, Zhang XM, Munk A, Zhang Y, Zhang D, Cline GW, Rothman DL, Petersen KF, Shulman GI. Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference. Cell Metabolism. PMID 33035493 DOI: 10.1016/j.cmet.2020.09.008  0.8
2020 Perry RJ, Shulman GI. Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. The Journal of Biological Chemistry. PMID 32796035 DOI: 10.1074/jbc.REV120.008387  0.8
2020 Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, ... ... Perry RJ, et al. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601203 DOI: 10.1073/pnas.1916121117  0.8
2020 Nozaki Y, Petersen MC, Zhang D, Vatner DF, Perry RJ, Abulizi A, Haedersdal S, Zhang XM, Butrico GM, Samuel VT, Mason GF, Cline GW, Petersen KF, Rothman DL, Shulman GI. Metabolic control analysis of hepatic glycogen synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 32188779 DOI: 10.1073/pnas.1921694117  0.8
2020 Perry RJ, Lyu K, Rabin-Court A, Dong J, Li X, Yang Y, Qing H, Wang A, Yang X, Shulman GI. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk. The Journal of Clinical Investigation. PMID 32149734 DOI: 10.1172/JCI134699  0.8
2020 Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, et al. Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature. PMID 32132708 DOI: 10.1038/s41586-020-2074-6  0.8
2020 Perry RJ, Shulman GI. Mechanistic Links between Obesity, Insulin, and Cancer. Trends in Cancer. 6: 75-78. PMID 32061306 DOI: 10.1016/j.trecan.2019.12.003  0.8
2020 Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proceedings of the National Academy of Sciences of the United States of America. PMID 31980524 DOI: 10.1073/pnas.1920004117  0.8
2019 Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ. SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism. 7: 10. PMID 31867105 DOI: 10.1186/s40170-019-0203-1  0.4
2019 Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, et al. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature Medicine. PMID 31700183 DOI: 10.1038/s41591-019-0610-4  0.8
2019 Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI. Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Science Translational Medicine. 11. PMID 31578240 DOI: 10.1126/scitranslmed.aay0284  0.8
2019 Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proceedings of the National Academy of Sciences of the United States of America. PMID 31213533 DOI: 10.1073/pnas.1901795116  0.8
2019 Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ. Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. Plos One. 14: e0218126. PMID 31188872 DOI: 10.1371/journal.pone.0218126  0.48
2019 Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA. Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function. The Journal of Biological Chemistry. PMID 30975900 DOI: 10.1074/jbc.RA118.006790  0.8
2019 Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30733621 DOI: 10.1038/s41591-018-0220-6  0.8
2019 Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI. Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. Nature Communications. 10: 548. PMID 30710078 DOI: 10.1038/s41467-019-08466-w  0.8
2019 Goedeke L, Perry RJ, Shulman GI. Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. Annual Review of Pharmacology and Toxicology. 59: 65-87. PMID 30625285 DOI: 10.1146/annurev-pharmtox-010716-104727  0.8
2018 Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30038219 DOI: 10.1038/s41591-018-0125-4  0.8
2018 Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports. 24: 47-55. PMID 29972790 DOI: 10.1016/j.celrep.2018.06.008  0.8
2018 Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology (Baltimore, Md.). PMID 29790582 DOI: 10.1002/hep.30097  0.8
2018 Perry RJ, Shulman GI. The Role of Leptin in Maintaining Plasma Glucose During Starvation. Postdoc Journal : a Journal of Postdoctoral Research and Postdoctoral Affairs. 6: 3-19. PMID 29682594 DOI: 10.14304/surya.jpr.v6n3.2  0.8
2018 Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF. Studies on the Mechanism of Methylenecyclopropylacetic acid and Methylenecyclopropylglycine-Induced Hypoglycemia. The Biochemical Journal. PMID 29483297 DOI: 10.1042/BCJ20180063  0.8
2018 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 9: 498. PMID 29386503 DOI: 10.1038/s41467-018-03023-3  0.8
2017 Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. PMID 29307489 DOI: 10.1016/j.cell.2017.12.001  0.8
2017 Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. PMID 29203511 DOI: 10.2337/db17-0524  0.8
2017 Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI. Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell Metabolism. PMID 29129786 DOI: 10.1016/j.cmet.2017.10.004  0.8
2017 Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 114: E9172-E9180. PMID 29073114 DOI: 10.1073/pnas.1707797114  0.8
2017 Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Reports. 21: 1021-1035. PMID 29069585 DOI: 10.1016/j.celrep.2017.09.091  0.8
2017 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 8: 798. PMID 28986525 DOI: 10.1038/s41467-017-01143-w  0.8
2017 Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 169: 148-160.e15. PMID 28340340 DOI: 10.1016/j.cell.2017.03.001  0.8
2017 Abulizi A, Perry RJ, Camporez JP, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28330852 DOI: 10.1096/fj.201700001R  0.8
2017 Corbit KC, Camporez JP, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. Jci Insight. 2: e91001. PMID 28194444 DOI: 10.1172/jci.insight.91001  0.8
2017 Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI. Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis. The Journal of Clinical Investigation. PMID 28112679 DOI: 10.1172/JCI88477  0.8
2017 Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI. A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo. Cell Metabolism. PMID 28111213 DOI: 10.1016/j.cmet.2016.12.017  0.8
2017 Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096339 DOI: 10.1073/pnas.1620506114  0.8
2016 Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG. Imeglimin Lowers Glucose Primarily by Amplifying Glucose-Stimulated Insulin Secretion in High Fat Fed Rodents. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00009.2016. PMID 27406738 DOI: 10.1152/ajpendo.00009.2016  0.76
2016 Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 534: 213-7. PMID 27279214 DOI: 10.1038/nature18309  0.76
2016 Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI. Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. The Journal of Biological Chemistry. PMID 27002151 DOI: 10.1074/jbc.M116.720631  0.76
2016 Perry RJ, Petersen KF, Shulman GI. Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis. Diabetologia. 59: 933-7. PMID 26961503 DOI: 10.1007/s00125-016-3909-4  0.76
2015 Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging. PMID 26647160  0.76
2015 Vatner DF, Snikeris J, Popov V, Perry RJ, Rahimi Y, Samuel VT. 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. Plos One. 10: e0140837. PMID 26485433 DOI: 10.1371/journal.pone.0140837  0.76
2015 Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Communications. 6: 6980. PMID 25916467 DOI: 10.1038/ncomms7980  0.76
2015 Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science (New York, N.Y.). 347: 1253-6. PMID 25721504 DOI: 10.1126/science.aaa0672  0.76
2015 Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 160: 745-58. PMID 25662011 DOI: 10.1016/j.cell.2015.01.012  0.76
2015 Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI. Response to burgess. Nature Medicine. 21: 109-10. PMID 25654597 DOI: 10.1038/nm.3790  0.76
2015 Petersen MC, Rahimi Y, Camporez JP, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 112: E825. PMID 25617370 DOI: 10.1073/pnas.1423574112  0.76
2014 Rahimi Y, Camporez JP, Petersen MC, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 16508-13. PMID 25368185 DOI: 10.1073/pnas.1419104111  0.76
2014 Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, et al. Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. American Journal of Physiology. Endocrinology and Metabolism. 307: E773-83. PMID 25159329 DOI: 10.1152/ajpendo.00148.2014  0.76
2014 Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Medicine. 20: 759-63. PMID 24929951 DOI: 10.1038/nm.3579  0.76
2014 Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510: 84-91. PMID 24899308 DOI: 10.1038/nature13478  0.76
2014 Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Medicine. 20: 98-102. PMID 24317120 DOI: 10.1038/nm.3415  0.76
2014 Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, et al. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 63: 1048-57. PMID 24222346 DOI: 10.2337/db13-0749  0.76
2013 Perry RJ, Shulman GI. Treating fatty liver and insulin resistance. Aging. 5: 791-2. PMID 24304662  0.76
2013 Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metabolism. 18: 740-8. PMID 24206666 DOI: 10.1016/j.cmet.2013.10.004  0.76
2013 Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B, Shulman GI. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging. 5: 770-81. PMID 24150286  0.76
2013 Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 12780-5. PMID 23840067 DOI: 10.1073/pnas.1311176110  0.76
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