Florence F. Wagner, Ph.D. - Publications

Affiliations: 
2006 North Carolina State University, Raleigh, NC 
Area:
Organic Chemistry

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorganic & Medicinal Chemistry. PMID 27377864 DOI: 10.1016/j.bmc.2016.06.040  1
2016 Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, ... ... Wagner FF, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angewandte Chemie (International Ed. in English). PMID 27355874 DOI: 10.1002/anie.201603797  1
2016 Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weiwer M, An WF, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology. PMID 27128528 DOI: 10.1021/acschembio.6b00306  1
2015 Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. Acs Chemical Biology. PMID 26640968 DOI: 10.1021/acschembio.5b00640  1
2015 Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB. Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chemistry & Biology. 22: 439-45. PMID 25892200 DOI: 10.1016/j.chembiol.2015.03.014  1
2015 Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chemical Science (Royal Society of Chemistry : 2010). 6: 804-815. PMID 25642316 DOI: 10.1039/C4SC02130D  1
2015 Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR. Correction: Sleiman et al., hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of hdac inhibition Journal of Neuroscience. 35: 438. DOI: 10.1523/JNEUROSCI.4746-14.2015  1
2014 Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR. Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14328-37. PMID 25339746 DOI: 10.1523/JNEUROSCI.1010-14.2014  1
2014 Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. Journal of Medicinal Chemistry. 57: 7999-8009. PMID 25203558 DOI: 10.1021/jm500872p  1
2014 Barton KM, Archin NM, Keedy KS, Espeseth AS, Zhang YL, Gale J, Wagner FF, Holson EB, Margolis DM. Selective HDAC inhibition for the disruption of latent HIV-1 infection. Plos One. 9: e102684. PMID 25136952 DOI: 10.1371/journal.pone.0102684  1
2014 Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, et al. An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. Acs Chemical Biology. 9: 2210-6. PMID 25089360 DOI: 10.1021/cb500492r  1
2014 Cash BM, Prevost N, Wagner FF, Comins DL. Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments. The Journal of Organic Chemistry. 79: 5740-5. PMID 24841361 DOI: 10.1021/jo500878v  1
2013 Wagner FF, WeÑ—wer M, Lewis MC, Holson EB. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 589-604. PMID 24101253 DOI: 10.1007/s13311-013-0226-1  1
2013 Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Medicinal Chemistry. 5: 1491-508. PMID 24024943 DOI: 10.4155/fmc.13.141  1
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. Plos One. 8: e71323. PMID 23967191 DOI: 10.1371/journal.pone.0071323  1
2013 Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neuroscience Letters. 550: 119-24. PMID 23810801 DOI: 10.1016/j.neulet.2013.06.016  1
2013 Ferguson BS, Harrison BC, Jeong MY, Reid BG, Wempe MF, Wagner FF, Holson EB, McKinsey TA. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: 9806-11. PMID 23720316 DOI: 10.1073/pnas.1301509110  1
2013 Frumm SM, Fan ZP, Ross KN, Duvall JR, Gupta S, VerPlank L, Suh BC, Holson E, Wagner FF, Smith WB, Paranal RM, Bassil CF, Qi J, Roti G, Kung AL, et al. Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chemistry & Biology. 20: 713-25. PMID 23706636 DOI: 10.1016/j.chembiol.2013.03.020  1
2013 Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, Weïwer M, Zhang YL, Holson EB. Discovery of the first histone deacetylase 6/8 dual inhibitors. Journal of Medicinal Chemistry. 56: 4816-20. PMID 23672185 DOI: 10.1021/jm400390r  1
2013 Wagner FF, Olson DE, Gale JP, Kaya T, Weïwer M, Aidoud N, Thomas M, Davoine EL, Lemercier BC, Zhang YL, Holson EB. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. Journal of Medicinal Chemistry. 56: 1772-6. PMID 23368884 DOI: 10.1021/jm301355j  1
2012 Lowe JT, Lee MD, Akella LB, Davoine E, Donckele EJ, Durak L, Duvall JR, Gerard B, Holson EB, Joliton A, Kesavan S, Lemercier BC, Liu H, Marié JC, Mulrooney CA, ... ... Wagner FF, et al. Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. The Journal of Organic Chemistry. 77: 7187-211. PMID 22853001 DOI: 10.1021/jo300974j  1
2012 Chou DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, Wagner BK. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chemistry & Biology. 19: 669-73. PMID 22726680 DOI: 10.1016/j.chembiol.2012.05.010  1
2012 Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 5364-9. PMID 22434908 DOI: 10.1073/pnas.1201079109  1
2011 Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1397-411. PMID 21389981 DOI: 10.1038/npp.2011.24  1
2010 Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 18: 436-47. PMID 21075309 DOI: 10.1016/j.ccr.2010.10.022  1
2010 Coleman JJ, Okoli I, Tegos GP, Holson EB, Wagner FF, Hamblin MR, Mylonakis E. Characterization of plant-derived saponin natural products against Candida albicans. Acs Chemical Biology. 5: 321-32. PMID 20099897 DOI: 10.1021/cb900243b  1
2007 Wagner FF, Comins DL. Recent advances in the synthesis of nicotine and its derivatives Tetrahedron. 63: 8065-8082. DOI: 10.1016/j.tet.2007.04.100  1
2006 Wagner FF, Comins DL. Expedient five-step synthesis of SIB-1508Y from natural nicotine. The Journal of Organic Chemistry. 71: 8673-5. PMID 17064057 DOI: 10.1021/jo0616052  1
2006 Wagner FF, Comins DL. Six-step synthesis of (S)-brevicolline from (S)-nicotine. Organic Letters. 8: 3549-52. PMID 16869657 DOI: 10.1021/ol061334h  1
2006 Wagner FF, Comins DL. Regioselective 5-, 4-, and 2-substitution of (S)-6-chloronicotine and 4-substitution of (S)-5-chloronicotine European Journal of Organic Chemistry. 3562-3565. DOI: 10.1002/ejoc.200600415  1
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