Paul Andrew Clemons - Publications

Affiliations: 
2001 Harvard University, Cambridge, MA, United States 

106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, ... ... Clemons PA, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8. PMID 31461650 DOI: 10.1016/j.celrep.2019.07.021  0.84
2019 Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature Communications. 10: 3003. PMID 31266947 DOI: 10.1038/s41467-019-10892-9  0.72
2019 Gerry CJ, Wawer MJ, Clemons PA, Schreiber SL. DNA barcoding a complete matrix of stereoisomeric small molecules. Journal of the American Chemical Society. PMID 31184885 DOI: 10.1021/jacs.9b01203  0.84
2019 Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, ... Clemons PA, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/j.cell.2019.04.009  0.72
2019 Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature Communications. 10: 1937. PMID 31028261 DOI: 10.1038/s41467-019-09987-0  0.72
2019 Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, ... ... Clemons PA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications. 10: 1617. PMID 30962421 DOI: 10.1038/s41467-019-09277-9  0.84
2019 Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, ... ... Clemons PA, et al. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chemical Biology. PMID 30880155 DOI: 10.1016/j.chembiol.2019.02.009  0.64
2019 Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Clemons PA, et al. Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition. Elife. 8. PMID 30860482 DOI: 10.7554/eLife.44161  0.84
2019 Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Clemons PA, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/s41591-018-0312-3  0.84
2019 Rees MG, Seashore-Ludlow B, Clemons PA. Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines. Methods in Molecular Biology (Clifton, N.J.). 1888: 233-254. PMID 30519951 DOI: 10.1007/978-1-4939-8891-4_14  0.4
2018 Melillo B, Zoller J, Hua BK, Verho O, Borghs J, Nelson SD, Maetani M, Wawer MJ, Clemons PA, Schreiber SL. Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds. Journal of the American Chemical Society. PMID 30133283 DOI: 10.1021/jacs.8b07319  0.84
2018 Basu A, Mitra R, Liu H, Schreiber SL, Clemons PA. RWEN: Response-Weighted Elastic Net For Prediction of Chemosensitivity of Cancer Cell Lines. Bioinformatics (Oxford, England). PMID 29688307 DOI: 10.1093/bioinformatics/bty199  0.84
2017 Aksoy BA, Dancík V, Smith K, Mazerik JN, Ji Z, Gross B, Nikolova O, Jaber N, Califano A, Schreiber SL, Gerhard DS, Hermida LC, Jagu S, Sander C, Floratos A, ... Clemons PA, et al. CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network. Database : the Journal of Biological Databases and Curation. 2017. PMID 29220450 DOI: 10.1093/database/bax054  0.84
2017 Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, ... ... Clemons PA, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 171: 1437-1452.e17. PMID 29195078 DOI: 10.1016/j.cell.2017.10.049  0.84
2017 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Clemons PA, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/nature23007  0.84
2017 Bray MA, Gustafsdottir SM, Ljosa V, Singh S, Sokolnicki KL, Bittker JA, Bodycombe NE, Dancík V, Hasaka TP, Hon CS, Kemp MM, Li K, Walpita D, Wawer MJ, Golub TR, ... ... Clemons PA, et al. A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay. Gigascience. PMID 28327978 DOI: 10.1093/gigascience/giw014  0.84
2016 Speyer G, Mahendra D, Tran HJ, Kiefer J, Schreiber SL, Clemons PA, Dhruv H, Berens M, Kim S. DIFFERENTIAL PATHWAY DEPENDENCY DISCOVERY ASSOCIATED WITH DRUG RESPONSE ACROSS CANCER CELL LINES. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 497-508. PMID 27897001  0.84
2016 Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, ... ... Clemons PA, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. PMID 27641501 DOI: 10.1016/j.cell.2016.08.057  0.36
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Clemons PA, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/nature19804  0.84
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.MCR-16-0090  0.84
2016 Gerry CJ, Hua BK, Wawer MJ, Knowles JP, Nelson SD, Verho O, Dandapani S, Wagner BK, Clemons PA, Booker-Milburn KI, Boskovic ZV, Schreiber SL. Real-Time Biological Annotation of Synthetic Compounds. Journal of the American Chemical Society. PMID 27398798 DOI: 10.1021/jacs.6b04614  0.36
2016 Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, ... ... Clemons PA, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987. PMID 27329820 DOI: 10.1038/ncomms11987  0.36
2016 Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, Clemons PA, Shamji A, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nature Communications. 7: 11428. PMID 27109210 DOI: 10.1038/ncomms11428  0.36
2016 Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, et al. DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27012813 DOI: 10.1158/1078-0432.CCR-15-3011  0.36
2016 Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A stimulates human beta-cell proliferation. Diabetes. PMID 26953159 DOI: 10.2337/db15-1127  0.36
2015 Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, ... ... Clemons PA, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/nchembio.1986  0.36
2015 de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature Chemical Biology. PMID 26656089 DOI: 10.1038/nchembio.1984  0.36
2015 Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, ... ... Clemons PA, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discovery. 5: 1210-23. PMID 26482930 DOI: 10.1158/2159-8290.CD-15-0235  0.84
2015 Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dan?ík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26195741 DOI: 10.1073/pnas.1512289112  0.36
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  0.84
2015 Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, ... ... Clemons PA, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/jacs.5b04284  0.84
2015 Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, ... ... Clemons PA, et al. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Reports. PMID 25660025 DOI: 10.1016/j.celrep.2015.01.017  0.84
2015 Burns SM, Vetere A, Walpita D, Dan?ík V, Khodier C, Perez J, Clemons PA, Wagner BK, Altshuler D. High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function. Cell Metabolism. 21: 126-37. PMID 25565210 DOI: 10.1016/j.cmet.2014.12.010  0.84
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.CD-14-0552  0.84
2015 Johannessen CM, Clemons PA, Wagner BK. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery. Trends in Genetics : Tig. 31: 16-23. PMID 25498789 DOI: 10.1016/j.tig.2014.11.002  0.84
2015 Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Clemons PA, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/nar/gku1244  0.84
2014 Jerby-Arnon L, Pfetzer N, Waldman YY, McGarry L, James D, Shanks E, Seashore-Ludlow B, Weinstock A, Geiger T, Clemons PA, Gottlieb E, Ruppin E. Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell. 158: 1199-209. PMID 25171417 DOI: 10.1016/j.cell.2014.07.027  0.84
2014 Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, et al. Evolving BioAssay Ontology (BAO): modularization, integration and applications. Journal of Biomedical Semantics. 5: S5. PMID 25093074 DOI: 10.1186/2041-1480-5-S1-S5  0.36
2014 Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular target of STF-31-like small-molecule probes. Acs Chemical Biology. 9: 2247-54. PMID 25058389 DOI: 10.1021/cb500347p  0.84
2014 Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, ... ... Clemons PA, et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proceedings of the National Academy of Sciences of the United States of America. 111: 10911-6. PMID 25024206 DOI: 10.1073/pnas.1410933111  0.84
2014 Green DV, Clemons PA. Knowledge from Small-Molecule Screening and Profiling Data. Journal of Biomolecular Screening. 19: 611-613. PMID 24842910 DOI: 10.1177/1087057114531209  0.84
2014 Choudhary A, Hu He K, Mertins P, Udeshi ND, Dan?ík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. Plos One. 9: e95194. PMID 24759943 DOI: 10.1371/journal.pone.0095194  0.84
2014 Wawer MJ, Jaramillo DE, Dan?ík V, Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, Clemons PA. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. Journal of Biomolecular Screening. 19: 738-748. PMID 24710340 DOI: 10.1177/1087057114530783  0.84
2014 Dan?ík V, Carrel H, Bodycombe NE, Seiler KP, Fomina-Yadlin D, Kubicek ST, Hartwell K, Shamji AF, Wagner BK, Clemons PA. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. Journal of Biomolecular Screening. 19: 771-781. PMID 24464433 DOI: 10.1177/1087057113520226  0.84
2014 de Souza A, Bittker JA, Lahr DL, Brudz S, Chatwin S, Oprea TI, Waller A, Yang JJ, Southall N, Guha R, Schürer SC, Vempati UD, Southern MR, Dawson ES, Clemons PA, et al. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines. Journal of Biomolecular Screening. 19: 614-627. PMID 24441647 DOI: 10.1177/1087057113517139  0.84
2014 Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 156: 317-31. PMID 24439385 DOI: 10.1016/j.cell.2013.12.010  0.84
2014 Gutierrez A, Pan L, Groen RWJ, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, et al. Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia Journal of Clinical Investigation. 124: 644-655. PMID 24401270 DOI: 10.1172/JCI65093  0.84
2013 Gustafsdottir SM, Ljosa V, Sokolnicki KL, Anthony Wilson J, Walpita D, Kemp MM, Petri Seiler K, Carrel HA, Golub TR, Schreiber SL, Clemons PA, Carpenter AE, Shamji AF. Multiplex cytological profiling assay to measure diverse cellular states. Plos One. 8: e80999. PMID 24312513 DOI: 10.1371/journal.pone.0080999  0.84
2013 Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, ... ... Clemons PA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature Chemical Biology. 9: 840-8. PMID 24161946 DOI: 10.1038/nchembio.1367  0.84
2013 Ljosa V, Caie PD, Ter Horst R, Sokolnicki KL, Jenkins EL, Daya S, Roberts ME, Jones TR, Singh S, Genovesio A, Clemons PA, Carragher NO, Carpenter AE. Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. Journal of Biomolecular Screening. 18: 1321-9. PMID 24045582 DOI: 10.1177/1087057113503553  0.84
2013 Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, ... ... Clemons PA, et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154: 1151-61. PMID 23993102 DOI: 10.1016/j.cell.2013.08.003  0.84
2013 Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, ... ... Clemons PA, et al. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. Plos Genetics. 9: e1003487. PMID 23696745 DOI: 10.1371/journal.pgen.1003487  0.84
2013 Mulrooney CA, Lahr DL, Quintin MJ, Youngsaye W, Moccia D, Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P, Bittker JA, Clemons PA, Brudz S, Dandapani S, Duvall JR, et al. An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. Journal of Computer-Aided Molecular Design. 27: 455-68. PMID 23585218 DOI: 10.1007/s10822-013-9641-y  0.84
2013 Schenone M, Dan?ík V, Wagner BK, Clemons PA. Target identification and mechanism of action in chemical biology and drug discovery. Nature Chemical Biology. 9: 232-40. PMID 23508189 DOI: 10.1038/nchembio.1199  0.84
2013 Dančík V, Basu A, Clemons P. Properties of biological networks Systems Biology. 1: 129-178. DOI: 10.1007/978-94-007-6803-1_5  0.84
2012 Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, ... ... Clemons PA, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell. 150: 575-89. PMID 22863010 DOI: 10.1016/j.cell.2012.06.032  0.84
2012 Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 5364-9. PMID 22434908 DOI: 10.1073/pnas.1201079109  0.84
2012 Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. Journal of Biomolecular Screening. 17: 509-18. PMID 22156222 DOI: 10.1177/1087057111430253  0.84
2012 Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA. Utility-aware screening with clique-oriented prioritization. Journal of Chemical Information and Modeling. 52: 29-37. PMID 22117901 DOI: 10.1021/ci2003285  0.84
2011 Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. Acs Chemical Biology. 6: 900-4. PMID 21732624 DOI: 10.1021/cb200206w  0.84
2011 Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA. Enhancing the rate of scaffold discovery with diversity-oriented prioritization. Bioinformatics (Oxford, England). 27: 2271-8. PMID 21685049 DOI: 10.1093/bioinformatics/btr369  0.84
2011 Seiler KP, Bodycombe NE, Hawkins T, Shell R, Lemon A, de Souza A, Clemons PA. Master data management: getting your house in order. Combinatorial Chemistry & High Throughput Screening. 14: 749-56. PMID 21631416 DOI: 10.2174/138620711796957189  0.84
2011 Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, Young DW. Route to three-dimensional fragments using diversity-oriented synthesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 6799-804. PMID 21482811 DOI: 10.1073/pnas.1015271108  0.84
2011 Clemons PA, Wilson JA, Dan?ík V, Muller S, Carrinski HA, Wagner BK, Koehler AN, Schreiber SL. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. Proceedings of the National Academy of Sciences of the United States of America. 108: 6817-22. PMID 21482810 DOI: 10.1073/pnas.1015024108  0.84
2011 Bochner BR, Siri M, Huang RH, Noble S, Lei XH, Clemons PA, Wagner BK. Assay of the multiple energy-producing pathways of mammalian cells. Plos One. 6: e18147. PMID 21455318 DOI: 10.1371/journal.pone.0018147  0.84
2011 Kim YK, Lee JS, Bi X, Ha HH, Ng SH, Ahn YH, Lee JJ, Wagner BK, Clemons PA, Chang YT. The binding of fluorophores to proteins depends on the cellular environment. Angewandte Chemie (International Ed. in English). 50: 2761-3. PMID 21370369 DOI: 10.1002/anie.201007626  0.84
2011 Ha SJ, Galazka JM, Kim SR, Choi JH, Yang X, Seo JH, Glass NL, Cate JH, Jin YS. Engineered Saccharomyces cerevisiae capable of simultaneous cellobiose and xylose fermentation. Proceedings of the National Academy of Sciences of the United States of America. 108: 504-9. PMID 21187422 DOI: 10.1073/pnas.1010456108  0.84
2011 Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL. Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes. Proceedings of the National Academy of Sciences of the United States of America. 108: 492-7. PMID 21183721 DOI: 10.1073/pnas.1016789108  0.32
2010 Muncipinto G, Kaya T, Wilson JA, Kumagai N, Clemons PA, Schreiber SL. Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions. Organic Letters. 12: 5230-3. PMID 20977261 DOI: 10.1021/ol102266j  0.84
2010 Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proceedings of the National Academy of Sciences of the United States of America. 107: 18787-92. PMID 20956335 DOI: 10.1073/pnas.1012741107  0.84
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  0.84
2010 Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 15099-104. PMID 20696901 DOI: 10.1073/pnas.1010018107  0.84
2010 Dancík V, Seiler KP, Young DW, Schreiber SL, Clemons PA. Distinct biological network properties between the targets of natural products and disease genes. Journal of the American Chemical Society. 132: 9259-61. PMID 20565092 DOI: 10.1021/ja102798t  0.84
2010 Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. Acs Chemical Biology. 5: 729-34. PMID 20550176 DOI: 10.1021/cb100129d  0.84
2010 Swamidass SJ, Bittker JA, Bodycombe NE, Ryder SP, Clemons PA. An economic framework to prioritize confirmatory tests after a high-throughput screen. Journal of Biomolecular Screening. 15: 680-6. PMID 20547534 DOI: 10.1177/1087057110372803  0.84
2010 Pizzirani D, Kaya T, Clemons PA, Schreiber SL. Stereochemical and skeletal diversity arising from amino propargylic alcohols Organic Letters. 12: 2822-2825. PMID 20481457 DOI: 10.1021/ol100914b  0.84
2009 Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 311-7. PMID 20023731 DOI: 10.1039/b821775k  0.84
2009 Wagner BK, Clemons PA. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling. Current Opinion in Chemical Biology. 13: 539-48. PMID 19825513 DOI: 10.1016/j.cbpa.2009.09.018  0.84
2009 Wilson JA, Bender A, Kaya T, Clemons PA. Alpha shapes applied to molecular shape characterization exhibit novel properties compared to established shape descriptors. Journal of Chemical Information and Modeling. 49: 2231-41. PMID 19775113 DOI: 10.1021/ci900190z  0.84
2009 Tanikawa T, Fridman M, Zhu W, Faulk B, Joseph IC, Kahne D, Wagner BK, Clemons PA. Using biological performance similarity to inform disaccharide library design. Journal of the American Chemical Society. 131: 5075-83. PMID 19298063 DOI: 10.1021/ja806583y  0.84
2008 Petri Seiler K, Kuehn H, Pat Happ M, Decaprio D, Clemons PA. Using ChemBank to probe chemical biology. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit 14.5. PMID 18551413 DOI: 10.1002/0471250953.bi1405s22  0.84
2008 Wagner BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, Clemons PA. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Journal of the American Chemical Society. 130: 4208-9. PMID 18327938 DOI: 10.1021/ja077656d  0.84
2008 Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA. ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Research. 36: D351-9. PMID 17947324 DOI: 10.1093/nar/gkm843  0.84
2008 Clemons PA. Chemical Informatics: Chemical Informatics Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 723-759. DOI: 10.1002/9783527619375.ch13a  0.84
2007 Bender A, Young DW, Jenkins JL, Serrano M, Mikhailov D, Clemons PA, Davies JW. Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Combinatorial Chemistry & High Throughput Screening. 10: 719-31. PMID 18045083 DOI: 10.2174/138620707782507313  0.84
2007 Duffner JL, Clemons PA, Koehler AN. A pipeline for ligand discovery using small-molecule microarrays. Current Opinion in Chemical Biology. 11: 74-82. PMID 17169601 DOI: 10.1016/j.cbpa.2006.11.031  0.84
2006 Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, ... Clemons PA, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.). 313: 1929-35. PMID 17008526 DOI: 10.1126/science.1132939  0.84
2006 Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, Eliasof S. Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics. Cancer Research. 66: 8935-42. PMID 16982730 DOI: 10.1158/0008-5472.CAN-06-2552  0.84
2006 Kelly KA, Clemons PA, Yu AM, Weissleder R. High-throughput identification of phage-derived imaging agents. Molecular Imaging. 5: 24-30. PMID 16779967 DOI: 10.1080/14650040500524053  0.84
2005 Forman JJ, Clemons PA, Schreiber SL, Haggarty SJ. SpectralNET--an application for spectral graph analysis and visualization. Bmc Bioinformatics. 6: 260. PMID 16236170 DOI: 10.1186/1471-2105-6-260  0.84
2004 Haggarty SJ, Clemons PA, Wong JC, Schreiber SL. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76. PMID 15578929  0.84
2004 Kim YK, Arai MA, Arai T, Lamenzo JO, Dean EF, Patterson N, Clemons PA, Schreiber SL. Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. Journal of the American Chemical Society. 126: 14740-5. PMID 15535697 DOI: 10.1021/ja048170p  0.84
2004 Wagner BK, Haggarty SJ, Clemons PA. Chemical genomics: probing protein function using small molecules. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 4: 313-20. PMID 15462609 DOI: 10.2165/00129785-200404050-00004  0.84
2004 Clemons PA. Complex phenotypic assays in high-throughput screening. Current Opinion in Chemical Biology. 8: 334-8. PMID 15183333 DOI: 10.1016/j.cbpa.2004.04.002  0.84
2003 Haggarty SJ, Clemons PA, Schreiber SL. Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. Journal of the American Chemical Society. 125: 10543-5. PMID 12940736 DOI: 10.1021/ja035413p  0.84
2003 Wang B, Nguyen M, Breckenridge DG, Stojanovic M, Clemons PA, Kuppig S, Shore GC. Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. The Journal of Biological Chemistry. 278: 14461-8. PMID 12529377 DOI: 10.1074/jbc.M209684200  0.84
2003 Clemons PA. Cross-town traffic Scientific Computing and Instrumentation. 20: 36-40+42.  0.84
2002 Clemons PA, Gladstone BG, Seth A, Chao ED, Foley MA, Schreiber SL. Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. Chemistry & Biology. 9: 49-61. PMID 11841938 DOI: 10.1016/S1074-5521(02)00085-6  0.84
2002 Wagner BK, Clemons PA. Dual-purpose drug discovery Trends in Biotechnology. 20: 492-493. DOI: 10.1016/S0167-7799(02)02097-8  0.84
2002 Wagner BK, Clemons PA. An even-handed approach Trends in Biotechnology. 20: 53.  0.64
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  0.84
2001 Blackwell HE, Clemons PA, Schreiber SL. Exploiting site-site interactions on solid support to generate dimeric molecules. Organic Letters. 3: 1185-8. PMID 11348190 DOI: 10.1021/ol015647i  0.84
2001 Wagner BK, Clemons PA. Better signaling through chemistry Trends in Biotechnology. 19: 127. DOI: 10.1016/S0167-7799(01)01611-0  0.64
2001 Clemons PA, Wagner BK. Hay in a needlestack? Trends in Biotechnology. 19: 435-436.  0.64
2000 Clemons PA. Be still my beating heart. Trends in Biotechnology. 18: 407. PMID 10998505 DOI: 10.1016/S0167-7799(00)01490-6  0.84
1999 Clemons PA. Design and discovery of protein dimerizers. Current Opinion in Chemical Biology. 3: 112-5. PMID 10021413 DOI: 10.1016/S1367-5931(99)80020-9  0.84
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