Joshua A. Bittker, Ph.D. - Publications

2004 Harvard University, Cambridge, MA, United States 
The Chemistry of Molecular Evolution

25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, ... ... Bittker JA, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/nchembio.1986  0.88
2015 Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, ... ... Bittker JA, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discovery. 5: 1210-23. PMID 26482930 DOI: 10.1158/2159-8290.CD-15-0235  0.88
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  0.88
2015 Park SW, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D, Aldrich CC. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis. Chemistry & Biology. 22: 76-86. PMID 25556942 DOI: 10.1016/j.chembiol.2014.11.012  0.88
2015 Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Bittker JA, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/nar/gku1244  0.88
2014 Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, et al. Evolving BioAssay Ontology (BAO): modularization, integration and applications. Journal of Biomedical Semantics. 5: S5. PMID 25093074 DOI: 10.1186/2041-1480-5-S1-S5  0.88
2014 Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, ... Bittker JA, et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proceedings of the National Academy of Sciences of the United States of America. 111: 10911-6. PMID 25024206 DOI: 10.1073/pnas.1410933111  0.88
2014 de Souza A, Bittker JA, Lahr DL, Brudz S, Chatwin S, Oprea TI, Waller A, Yang JJ, Southall N, Guha R, Schürer SC, Vempati UD, Southern MR, Dawson ES, Clemons PA, et al. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines. Journal of Biomolecular Screening. 19: 614-627. PMID 24441647 DOI: 10.1177/1087057113517139  0.88
2013 Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, ... ... Bittker JA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature Chemical Biology. 9: 840-8. PMID 24161946 DOI: 10.1038/nchembio.1367  0.88
2013 Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, ... ... Bittker JA, et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154: 1151-61. PMID 23993102 DOI: 10.1016/j.cell.2013.08.003  0.88
2013 Youngsaye W, Hartland CL, Morgan BJ, Ting A, Nag PP, Vincent B, Mosher CA, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans. Beilstein Journal of Organic Chemistry. 9: 1501-7. PMID 23946849 DOI: 10.3762/bjoc.9.171  0.88
2013 Mulrooney CA, Lahr DL, Quintin MJ, Youngsaye W, Moccia D, Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P, Bittker JA, Clemons PA, Brudz S, Dandapani S, Duvall JR, et al. An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. Journal of Computer-Aided Molecular Design. 27: 455-68. PMID 23585218 DOI: 10.1007/s10822-013-9641-y  0.88
2012 Calhoun BT, Browning MR, Chen BR, Bittker JA, Swamidass SJ. Automatically detecting workflows in PubChem. Journal of Biomolecular Screening. 17: 1071-9. PMID 22693105 DOI: 10.1177/1087057112449054  0.88
2012 Youngsaye W, Dockendorff C, Vincent B, Hartland CL, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorganic & Medicinal Chemistry Letters. 22: 3362-5. PMID 22497765 DOI: 10.1016/j.bmcl.2012.02.035  0.88
2012 Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters. 22: 1822-6. PMID 22297109 DOI: 10.1016/j.bmcl.2011.09.047  0.88
2012 Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA. Utility-aware screening with clique-oriented prioritization. Journal of Chemical Information and Modeling. 52: 29-37. PMID 22117901 DOI: 10.1021/ci2003285  0.88
2011 Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorganic & Medicinal Chemistry Letters. 21: 7197-200. PMID 22018462 DOI: 10.1016/j.bmcl.2011.09.057  0.88
2011 Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorganic & Medicinal Chemistry Letters. 21: 5502-5. PMID 21802942 DOI: 10.1016/j.bmcl.2011.06.105  0.88
2011 Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA. Enhancing the rate of scaffold discovery with diversity-oriented prioritization. Bioinformatics (Oxford, England). 27: 2271-8. PMID 21685049 DOI: 10.1093/bioinformatics/btr369  0.88
2010 Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 15099-104. PMID 20696901 DOI: 10.1073/pnas.1010018107  0.88
2010 Swamidass SJ, Bittker JA, Bodycombe NE, Ryder SP, Clemons PA. An economic framework to prioritize confirmatory tests after a high-throughput screen. Journal of Biomolecular Screening. 15: 680-6. PMID 20547534 DOI: 10.1177/1087057110372803  0.88
2005 Liu JM, Bittker JA, Lonshteyn M, Liu DR. Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection. Chemistry & Biology. 12: 757-67. PMID 16039523 DOI: 10.1016/j.chembiol.2005.05.014  0.88
2004 Bittker JA, Le BV, Liu JM, Liu DR. Directed evolution of protein enzymes using nonhomologous random recombination. Proceedings of the National Academy of Sciences of the United States of America. 101: 7011-6. PMID 15118093 DOI: 10.1073/pnas.0402202101  0.88
2002 Bittker JA, Le BV, Liu DR. Nucleic acid evolution and minimization by nonhomologous random recombination. Nature Biotechnology. 20: 1024-9. PMID 12219078 DOI: 10.1038/nbt736  0.88
2002 Bittker JA, Phillips KJ, Liu DR. Recent advances in the in vitro evolution of nucleic acids. Current Opinion in Chemical Biology. 6: 367-74. PMID 12023118 DOI: 10.1016/S1367-5931(02)00321-6  0.88
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