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Danny Hung-Chieh Chou, Ph.D. - Publications

Affiliations: 
2007-2011 Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
 2011-2014 Chemical Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
 2014-2020 Biochemistry University of Utah, Salt Lake City, UT 
 2020- Pediatrics Stanford University, Palo Alto, CA 
Area:
Chemical biology
Website:
https://www.dannychoulab.com
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Li W, Jacobsen MT, Park C, Jung JU, Lin NP, Huang PS, Lal RA, Chou DH. A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets. Chemical Science. 15: 3214-3222. PMID 38425513 DOI: 10.1039/d3sc06032b  0.328
2024 Zhang YW, Lin NP, Guo X, Szabo-Fresnais N, Ortoleva PJ, Chou DH. Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering. Acs Chemical Biology. PMID 38266161 DOI: 10.1021/acschembio.3c00685  0.403
2023 Zhang YW, Zheng N, Chou DH. Serine-mediated hydrazone ligation displaying insulin-like peptides on M13 phage pIII. Organic & Biomolecular Chemistry. PMID 37905463 DOI: 10.1039/d3ob01487h  0.541
2023 Meudom R, Zhang Y, VandenBerg MA, Zou L, Zhang YW, Webber MJ, Chou DH. Supramolecular approaches for insulin stabilization without prolonged duration of action. Acta Pharmaceutica Sinica. B. 13: 2281-2290. PMID 37250160 DOI: 10.1016/j.apsb.2023.01.007  0.603
2023 Park C, Zhang Y, Jung JU, Buron LD, Lin NP, Hoeg-Jensen T, Chou DH. Antagonistic Insulin Derivative Suppresses Insulin-Induced Hypoglycemia. Journal of Medicinal Chemistry. PMID 37227951 DOI: 10.1021/acs.jmedchem.3c00280  0.379
2022 Clauss ZS, Meudom R, Su B, VandenBerg MA, Saini SS, Webber MJ, Chou DH, Kramer JR. Supramolecular Protein Stabilization with Zwitterionic Polypeptide-Cucurbit[7]uril Conjugates. Biomacromolecules. 24: 481-488. PMID 36512327 DOI: 10.1021/acs.biomac.2c01319  0.553
2022 Laugesen SH, Chou DH, Safavi-Hemami H. Unconventional insulins from predators and pathogens. Nature Chemical Biology. 18: 688-697. PMID 35761080 DOI: 10.1038/s41589-022-01068-6  0.352
2022 Lin NP, Zheng N, Purushottam L, Zhang YW, Chou DH. Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility. Frontiers in Chemistry. 10: 859133. PMID 35372263 DOI: 10.3389/fchem.2022.859133  0.71
2022 Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, ... ... Chou DH, et al. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nature Chemical Biology. PMID 35289328 DOI: 10.1038/s41589-022-00981-0  0.391
2021 Disotuar MM, Smith JA, Li J, Alam S, Lin NP, Chou DH. Facile synthesis of insulin fusion derivatives through sortase A ligation. Acta Pharmaceutica Sinica. B. 11: 2719-2725. PMID 34589392 DOI: 10.1016/j.apsb.2020.11.011  0.361
2021 Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain. Journal of Medicinal Chemistry. PMID 34161094 DOI: 10.1021/acs.jmedchem.1c00802  0.699
2020 Zheng N, Christensen S, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH. Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry. PMID 32597184 DOI: 10.1021/Acs.Jmedchem.0C00613  0.7
2020 Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, ... ... Chou DH, et al. Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nature Structural & Molecular Biology. PMID 32533129 DOI: 10.1038/s41594-020-0460-2  0.311
2020 Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, ... ... Chou DH, et al. A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nature Structural & Molecular Biology. PMID 32483339 DOI: 10.1038/S41594-020-0430-8  0.484
2020 Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Chou DH. Novel four-disulfide insulin analog with high aggregation stability and potency. Chemical Science. 11: 195-200. PMID 32110371 DOI: 10.1039/C9Sc04555D  0.64
2019 Zheng N, Karra P, VandenBerg M, Kim JH, Webber MJ, Holland W, Chou DH. Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analog with Enhanced Stability. Journal of Medicinal Chemistry. PMID 31804076 DOI: 10.1021/Acs.Jmedchem.9B01589  0.67
2019 Disotuar MM, Chen D, Lin NP, Chou DH. Glucose-Responsive Insulin Through Bioconjugation Approaches. Journal of Diabetes Science and Technology. 1932296819854105. PMID 31216874 DOI: 10.1177/1932296819854105  0.457
2018 Jeong MY, Rutter J, Chou DH. Display of single-chain insulin-like peptides on yeast surface. Biochemistry. PMID 30575376 DOI: 10.1021/Acs.Biochem.8B01094  0.385
2018 Disotuar MM, Petersen ME, Nogueira JM, Kay MS, Chou DH. Synthesis of hydrophobic insulin-based peptides using a helping hand strategy. Organic & Biomolecular Chemistry. PMID 29947407 DOI: 10.1039/C8Ob01212A  0.661
2018 Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Salcedo PF, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Chou DH, Safavi-Hemami H. Author response: Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor Elife. DOI: 10.7554/Elife.41574.034  0.374
2017 Chen D, Disotuar MM, Xiong X, Wang Y, Chou DH. Selective N-terminal functionalization of native peptides and proteins. Chemical Science. 8: 2717-2722. PMID 28553506 DOI: 10.1039/C6Sc04744K  0.342
2017 Menting JG, Chou DH, MacRaild CA, Smith NA, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC. Venom evolution provides inspiration for development of ultrafast-acting insulins Acta Crystallographica Section a Foundations and Advances. 73: C243-C243. DOI: 10.1107/S2053273317093305  0.326
2016 Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC. A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nature Structural & Molecular Biology. PMID 27617429 DOI: 10.1038/nsmb.3292  0.354
2015 Wang Y, Chou DH. A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization. Angewandte Chemie (International Ed. in English). PMID 26189498 DOI: 10.1002/Anie.201503975  0.337
2015 Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/Jacs.5B04284  0.673
2015 Chou DH, Webber MJ, Tang BC, Lin AB, Thapa LS, Deng D, Truong JV, Cortinas AB, Langer R, Anderson DG. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. Proceedings of the National Academy of Sciences of the United States of America. 112: 2401-6. PMID 25675515 DOI: 10.1073/Pnas.1424684112  0.728
2012 Chou DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, Wagner BK. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chemistry & Biology. 19: 669-73. PMID 22726680 DOI: 10.1016/J.Chembiol.2012.05.010  0.646
2011 Chou DH, Duvall JR, Gerard B, Liu H, Pandya BA, Suh BC, Forbeck EM, Faloon P, Wagner BK, Marcaurelle LA. Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. Acs Medicinal Chemistry Letters. 2: 698-702. PMID 21927648 DOI: 10.1021/Ml200120M  0.62
2010 Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. Acs Chemical Biology. 5: 729-34. PMID 20550176 DOI: 10.1021/Cb100129D  0.712
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