Johnathan R. Whetstine, Ph.D. - Publications

2002 Wayne State University, Detroit, MI, United States 
Molecular Biology, Pharmacology

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Van Rechem C, Ji F, Chakraborty D, Black JC, Sadreyev RI, Whetstine JR. Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell Reports. 37: 109799. PMID 34610305 DOI: 10.1016/j.celrep.2021.109799  1
2020 Van Rechem C, Ji F, Mishra S, Chakraborty D, Murphy SE, Dillingham ME, Sadreyev RI, Whetstine JR. The lysine demethylase KDM4A controls the cell-cycle expression of replicative canonical histone genes. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194624. PMID 32798738 DOI: 10.1016/J.Bbagrm.2020.194624  1
2019 Clarke TL, Tang R, Chakraborty D, Van Rechem C, Ji F, Mishra S, Ma A, Kaniskan HU, Jin J, Lawrence MS, Sadreyev RI, Whetstine JR. Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification. Cancer Discovery. PMID 31776131 DOI: 10.1158/2159-8290.Cd-19-0463  1
2019 Whetstine JR. PRC2 Plays Red Light, Green Light with MHC-I and CD8 T Cells. Cancer Cell. 36: 343-345. PMID 31614112 DOI: 10.1016/j.ccell.2019.09.010  0.01
2019 Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, ... ... Whetstine JR, et al. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Molecular Cell. PMID 31399344 DOI: 10.1016/J.Molcel.2019.06.034  1
2018 Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 175: 1716. PMID 30500540 DOI: 10.1016/j.cell.2018.11.018  1
2018 Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. PMID 30057114 DOI: 10.1016/J.Cell.2018.06.018  1
2018 Whetstine JR. Abstract CN07-02: Epigenetics: A gatekeeper to DNA amplification Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Cn07-02  0.01
2017 Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Developmental Cell. 43: 689-703.e5. PMID 29233476 DOI: 10.1016/J.Devcel.2017.11.008  1
2017 Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, ... Whetstine J, et al. Radiation resistance in KRAS-mutated lung cancer is enabled by stem-like properties mediated by an osteopontin-EGFR pathway. Cancer Research. PMID 28202526 DOI: 10.1158/0008-5472.Can-16-0808  1
2017 Rechem CV, Black JC, Greninger P, Zhao Y, Boukhali M, Donado C, Aryee MJ, Burrowes Pd, Ladd B, Gräslund S, Haas W, Christiani DC, Benes CH, Whetstine JR. Abstract NTOC-110: UNEXPECTED ROLES FOR KDM4A: PROTEIN SYNTHESIS AND MTOR INHIBITOR SENSITIVITY Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Ntoc-110  1
2017 Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, ... Whetstine JR, et al. Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance Cancer Research. 77: 4756-4756. DOI: 10.1158/1538-7445.Am2017-4756  1
2016 Black JC, Zhang H, Kim J, Getz G, Whetstine JR. Regulation of Transient Site-specific Copy Gain by microRNA. The Journal of Biological Chemistry. PMID 26755726 DOI: 10.1074/Jbc.M115.711648  1
2016 Mishra S, Whetstine JR. Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive. Molecular and Cellular Biology. PMID 26755558 DOI: 10.1128/Mcb.00652-15  1
2015 Black JC, Whetstine JR. RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma. Cancer Discovery. 5: 1241-3. PMID 26637658 DOI: 10.1158/2159-8290.Cd-15-1285  1
2015 Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, ... ... Whetstine J, et al. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nature Medicine. PMID 26501192 DOI: 10.1038/Nm.3980  1
2015 Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, ... Whetstine JR, et al. SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes. Nature Communications. 6: 8257. PMID 26394836 DOI: 10.1038/Ncomms9257  1
2015 Black JC, Whetstine JR. Too little O2 Too much gain. Cell Cycle (Georgetown, Tex.). 14: 2869-70. PMID 26221746 DOI: 10.1080/15384101.2015.1076659  1
2015 Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, ... ... Whetstine JR, et al. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes & Development. 29: 1018-31. PMID 25995187 DOI: 10.1101/Gad.259796.115  1
2015 Van Rechem C, Black JC, Greninger P, Zhao Y, Donado C, Burrowes PD, Ladd B, Christiani DC, Benes CH, Whetstine JR. A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors. Cancer Discovery. 5: 245-54. PMID 25564517 DOI: 10.1158/2159-8290.Cd-14-1159  1
2015 Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gräslund S, Haas W, Benes CH, Whetstine JR. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discovery. 5: 255-63. PMID 25564516 DOI: 10.1158/2159-8290.Cd-14-1326  1
2015 Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Keith Joung J, Iliopoulos O, Montagna C, ... ... Whetstine JR, et al. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression Genes and Development. 29: 1018-1031. DOI: 10.1101/gad.259796.115  1
2014 Whetstine JR. Methylation: a multifaceted modification - looking at transcription and beyond. Biochimica Et Biophysica Acta. 1839: 1351-2. PMID 25225044 DOI: 10.1016/J.Bbagrm.2014.09.005  1
2014 Van Rechem C, Whetstine JR. Examining the impact of gene variants on histone lysine methylation. Biochimica Et Biophysica Acta. 1839: 1463-76. PMID 24859469 DOI: 10.1016/J.Bbagrm.2014.05.014  1
2013 Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Reports. 5: 1679-89. PMID 24360956 DOI: 10.1016/J.Celrep.2013.11.034  1
2013 Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, ... ... Whetstine JR, et al. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Science Translational Medicine. 5: 212ra162. PMID 24259050 DOI: 10.1126/Scitranslmed.3006840  1
2013 Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, ... Whetstine JR, et al. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 154: 541-55. PMID 23871696 DOI: 10.1016/J.Cell.2013.06.051  1
2013 Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: 279-86. PMID 23399959 DOI: 10.1097/Jto.0B013E31827Ecf83  1
2013 Black JC, Whetstine JR. Tipping the lysine methylation balance in disease. Biopolymers. 99: 127-35. PMID 23175387 DOI: 10.1002/Bip.22136  1
2012 Black JC, Van Rechem C, Whetstine JR. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Molecular Cell. 48: 491-507. PMID 23200123 DOI: 10.1016/J.Molcel.2012.11.006  1
2012 Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ. RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Molecular and Cellular Biology. 32: 4375-87. PMID 22927638 DOI: 10.1128/Mcb.00536-12  1
2012 Black JC, Whetstine JR. LOX out, histones: a new enzyme is nipping at your tails. Molecular Cell. 46: 243-4. PMID 22578539 DOI: 10.1016/J.Molcel.2012.04.023  1
2011 Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. The Journal of Biological Chemistry. 286: 30462-70. PMID 21757720 DOI: 10.1074/Jbc.M111.273508  1
2011 Black JC, Whetstine JR. Chromatin landscape: methylation beyond transcription. Epigenetics. 6: 9-15. PMID 20855937 DOI: 10.4161/Epi.6.1.13331  1
2010 Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR. Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Molecular Cell. 40: 736-48. PMID 21145482 DOI: 10.1016/J.Molcel.2010.11.008  1
2010 Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, ... ... Whetstine JR, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes & Development. 24: 1403-17. PMID 20595232 DOI: 10.1101/Gad.1901210  1
2010 Whetstine JR. Histone methylation. chemically inert but chromatin dynamic Handbook of Cell Signaling, 2/E. 3: 2389-2397. DOI: 10.1016/B978-0-12-374145-5.00287-4  1
2009 Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nature Cell Biology. 11: 1376-82. PMID 19783983 DOI: 10.1038/Ncb1982  1
2009 Chen S, Whetstine JR, Ghosh S, Hanover JA, Gali RR, Grosu P, Shi Y. The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proceedings of the National Academy of Sciences of the United States of America. 106: 1496-501. PMID 19164523 DOI: 10.1073/Pnas.0802674106  1
2007 Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 449: 689-94. PMID 17851529 DOI: 10.1038/Nature06192  1
2007 Chen Z, Zang J, Kappler J, Hong X, Crawford F, Wang Q, Lan F, Jiang C, Whetstine J, Dai S, Hansen K, Shi Y, Zhang G. Structural basis of the recognition of a methylated histone tail by JMJD2A. Proceedings of the National Academy of Sciences of the United States of America. 104: 10818-23. PMID 17567753 DOI: 10.1073/Pnas.0704525104  1
2007 Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 128: 1077-88. PMID 17320160 DOI: 10.1016/J.Cell.2007.02.017  1
2007 Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Molecular Cell. 25: 1-14. PMID 17218267 DOI: 10.1016/J.Molcel.2006.12.010  1
2006 Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 125: 691-702. PMID 16677698 DOI: 10.1016/J.Cell.2006.04.024  1
2006 Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 125: 467-81. PMID 16603238 DOI: 10.1016/J.Cell.2006.03.028  1
2005 Whetstine JR, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Molecular Cell. 18: 483-90. PMID 15893731 DOI: 10.1016/J.Molcel.2005.04.006  1
2005 Payton SG, Whetstine JR, Ge Y, Matherly LH. Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor. Biochimica Et Biophysica Acta. 1727: 45-57. PMID 15652157 DOI: 10.1016/J.Bbaexp.2004.11.006  1
2004 Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 119: 941-53. PMID 15620353 DOI: 10.1016/j.cell.2004.12.012  1
2004 Liu M, Whetstine JR, Payton SG, Ge Y, Flatley RM, Matherly LH. Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. The Biochemical Journal. 383: 249-57. PMID 15214842 DOI: 10.1042/Bj20040414  1
2003 Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature. 422: 735-8. PMID 12700765 DOI: 10.1038/Nature01550  1
2002 Gifford AJ, Haber M, Witt TL, Whetstine JR, Taub JW, Matherly LH, Norris MD. Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia. 16: 2379-87. PMID 12454742 DOI: 10.1038/Sj.Leu.2402655  1
2002 Whetstine JR, Witt TL, Matherly LH. The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. The Journal of Biological Chemistry. 277: 43873-80. PMID 12228234 DOI: 10.1074/Jbc.M208296200  1
2002 Whetstine JR, Flatley RM, Matherly LH. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. The Biochemical Journal. 367: 629-40. PMID 12144527 DOI: 10.1042/Bj20020512  1
2001 Whetstine JR, Gifford AJ, Witt T, Liu XY, Flatley RM, Norris M, Haber M, Taub JW, Ravindranath Y, Matherly LH. Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 3416-22. PMID 11705857  1
2001 Ding BC, Whetstine JR, Witt TL, Schuetz JD, Matherly LH. Repression of human reduced folate carrier gene expression by wild type p53. The Journal of Biological Chemistry. 276: 8713-9. PMID 11106643 DOI: 10.1074/Jbc.M005248200  1
2001 Whetstine JR, Matherly LH. The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element: Basis for tissue-specific gene expression Journal of Biological Chemistry. 276: 6350-6358. PMID 11078737 DOI: 10.1074/Jbc.M008074200  1
2001 Jacobshagen S, Whetstine JR, Boling JM. Many but not all genes in Chlamydomonas reinhardtii are regulated by the circadian clock Plant Biology. 3: 592-597. DOI: 10.1055/s-2001-19370  1
2000 Whetstine JR, Yueh MF, Hopp KA, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN. Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: Detection of expressed protein in African-Americans Toxicology and Applied Pharmacology. 168: 216-224. PMID 11042094 DOI: 10.1006/Taap.2000.9050  1
1998 Green TK, Pesterfield LL, Radmard B, Whetstine JR. Methylation of tetrakis(fod) europate NMR shift reagent by S-methyldibenzothiophenium ion Magnetic Resonance in Chemistry. 36: 79-86.  1
1997 Green TK, Whetstine JR, Son EJR. Enantiomeric purity of alkylmethylphenylsulfonium ions with chiral NMR shift reagents: Racemization by pyramidal inversion as observed by 1H NMR spectroscopy Tetrahedron Asymmetry. 8: 3175-3181. DOI: 10.1016/S0957-4166(97)00383-2  1
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