245 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Vuilleumier N, Pagano S, Combescure C, Gencer B, Virzi J, Räber L, Carballo D, Carballo S, Nanchen D, Rodondi N, Windecker S, Hazen SL, Wang Z, Li XS, von Eckardstein A, et al. Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes. Journal of Clinical Medicine. 8. PMID 31324073 DOI: 10.3390/jcm8071002  0.52
2019 Winther SA, Øllgaard JC, Tofte N, Tarnow L, Wang Z, Ahluwalia TS, Jorsal A, Theilade S, Parving HH, Hansen TW, Hazen SL, Pedersen O, Rossing P. Utility of Plasma Concentration of Trimethylamine -Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes. Diabetes Care. PMID 31123156 DOI: 10.2337/dc19-0048  0.52
2019 Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, et al. Genetic Deficiency of Flavin-Containing Monooxygenase-3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312592. PMID 31070450 DOI: 10.1161/ATVBAHA.119.312592  0.52
2019 Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, ... ... Hazen SL, et al. Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease. Journal of the American Heart Association. 8: e011922. PMID 31070104 DOI: 10.1161/JAHA.119.011922  0.52
2019 Li XS, Obeid S, Wang Z, Hazen BJ, Li L, Wu Y, Hurd AG, Gu X, Pratt A, Levison BS, Chung YM, Nissen SE, Tang WHW, Mach F, Räber L, ... ... Hazen SL, et al. Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes. European Heart Journal. PMID 31049589 DOI: 10.1093/eurheartj/ehz259  0.72
2019 Erickson ML, Malin SK, Wang Z, Brown JM, Hazen SL, Kirwan JP. Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults. Nutrients. 11. PMID 30654453 DOI: 10.3390/nu11010179  0.52
2018 Wang Z, Bergeron N, Levison BS, Li XS, Chiu S, Jia X, Koeth RA, Li L, Wu Y, Tang WHW, Krauss RM, Hazen SL. Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. European Heart Journal. PMID 30535398 DOI: 10.1093/eurheartj/ehy799  0.72
2018 Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D, Cody DB, Dai HJ, Culley MK, Li XS, Fu X, Wu Y, Li L, ... ... Hazen SL, et al. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. The Journal of Clinical Investigation. PMID 30530985 DOI: 10.1172/JCI94601  1
2018 Comhair SAA, Bochenek G, Baicker-McKee S, Wang Z, Stachura T, Sanak M, Hammel JP, Hazen SL, Erzurum SC, Nizankowska-Mogilnicka E. The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease. Respiratory Research. 19: 210. PMID 30376852 DOI: 10.1186/s12931-018-0909-6  1
2018 Skye SM, Zhu W, Romano KA, Guo CJ, Wang Z, Jia X, Kirsop J, Haag B, Lang JM, DiDonato JA, Tang WHW, Lusis AJ, Rey FE, Fischbach MA, Hazen SL. Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential. Circulation Research. 123: 1164-1176. PMID 30359185 DOI: 10.1161/CIRCRESAHA.118.313142  1
2018 Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, et al. Loss of HDAC6 alters gut microbiota and worsens obesity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701586R. PMID 30102568 DOI: 10.1096/fj.201701586R  0.52
2018 Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, ... ... Hazen SL, et al. Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential. Nature Medicine. PMID 30082863 DOI: 10.1038/s41591-018-0128-1  1
2018 Vallance HD, Koochin A, Branov J, Rosen-Heath A, Bosdet T, Wang Z, Hazen SL, Horvath G. Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine. Molecular Genetics and Metabolism Reports. 15: 130-133. PMID 30023305 DOI: 10.1016/j.ymgmr.2018.04.005  0.52
2018 Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL. Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk. Journal of Thrombosis and Haemostasis : Jth. PMID 29981269 DOI: 10.1111/jth.14234  1
2018 Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, ... ... Hazen SL, et al. Gut Microbiota-Dependent Trimethylamine -Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29976769 DOI: 10.1161/ATVBAHA.118.311023  0.52
2018 Chandrasekharan UM, Wang Z, Wu Y, Wilson Tang WH, Hazen SL, Wang S, Elaine Husni M. Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis. Arthritis Research & Therapy. 20: 123. PMID 29884228 DOI: 10.1186/s13075-018-1616-x  0.52
2018 Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, ... ... Hazen SL, et al. Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase. Jci Insight. 3. PMID 29875311 DOI: 10.1172/jci.insight.97530  1
2018 Norheim F, Bjellaas T, Hui ST, Chella Krishnan K, Lee J, Gupta S, Pan C, Hasin-Brumshtein Y, Parks BW, Li D, Bui H, Mosier M, Wu Y, Huertas-Vazquez A, Hazen SW, et al. Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance. Journal of Lipid Research. PMID 29739864 DOI: 10.1194/jlr.M081398  0.72
2018 Halawani D, Gogonea V, DiDonato JA, Pipich V, Yao P, China A, Topbas C, Vasu K, Arif A, Hazen SL, Fox PL. Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains. The Journal of Biological Chemistry. PMID 29643180 DOI: 10.1074/jbc.M117.807503  1
2018 Smits LP, Kootte RS, Levin E, Prodan A, Fuentes S, Zoetendal EG, Wang Z, Levison BS, Cleophas MCP, Kemper EM, Dallinga-Thie GM, Groen AK, Joosten LAB, Netea MG, Stroes ESG, ... ... Hazen SL, et al. Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome. Journal of the American Heart Association. 7. PMID 29581220 DOI: 10.1161/JAHA.117.008342  0.72
2018 Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, ... ... Hazen SL, et al. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. Jci Insight. 3. PMID 29563342 DOI: 10.1172/jci.insight.99096  1
2017 Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Franke JD, Hartman CL, McHowat J, Ford DA. Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. Jci Insight. 2. PMID 29212955 DOI: 10.1172/jci.insight.96432  1
2017 Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL. Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget. 8: 71965-71980. PMID 29069761 DOI: 10.18632/oncotarget.18666  1
2017 Kim HW, Blomkalns AL, Ogbi M, Thomas M, Gavrila D, Neltner BS, Cassis LA, Thompson RW, Weiss RM, Lindower PD, Blanco VM, McCormick ML, Daugherty A, Fu X, Hazen SL, et al. Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00296.2017. PMID 28971841 DOI: 10.1152/ajpheart.00296.2017  0.52
2017 Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, ... ... Hazen SL, et al. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Reports. 20: 279. PMID 28683320 DOI: 10.1016/j.celrep.2017.06.053  0.52
2017 Zamanian-Daryoush M, Lindner DJ, DiDonato JA, Wagner M, Buffa J, Rayman P, Parks JS, Westerterp M, Tall AR, Hazen SL. Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget. PMID 28666268 DOI: 10.18632/oncotarget.18666  1
2017 Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, ... ... Hazen SL, et al. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Reports. 19: 2451-2461. PMID 28636934 DOI: 10.1016/j.celrep.2017.05.077  0.52
2017 Garcia E, Wolak-Dinsmore J, Wang Z, Li XS, Bennett DW, Connelly MA, Otvos JD, Hazen SL, Jeyarajah EJ. NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting. Clinical Biochemistry. PMID 28624482 DOI: 10.1016/j.clinbiochem.2017.06.003  0.52
2017 Janssen AW, Houben T, Katiraei S, Dijk W, Boutens L, van der Bolt N, Wang Z, Brown JM, Hazen SL, Mandard S, Shiri-Sverdlov R, Kuipers F, Willems van Dijk K, Vervoort J, Stienstra R, et al. Modulation of the gut microbiota impacts non-alcoholic fatty liver disease: a potential role for bile acids. Journal of Lipid Research. PMID 28533304 DOI: 10.1194/jlr.M075713  0.52
2017 Zhu W, Wang Z, Tang WHW, Hazen SL. Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects. Circulation. 135: 1671-1673. PMID 28438808 DOI: 10.1161/CIRCULATIONAHA.116.025338  0.52
2017 Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang Z, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biology. 18: 70. PMID 28407784 DOI: 10.1186/s13059-017-1194-2  0.52
2017 Li XS, Obeid S, Klingenberg R, Gencer B, Mach F, Räber L, Windecker S, Rodondi N, Nanchen D, Muller O, Miranda MX, Matter CM, Wu Y, Li L, Wang Z, ... ... Hazen SL, et al. Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European Heart Journal. PMID 28077467 DOI: 10.1093/eurheartj/ehw582  0.72
2017 Guertin KA, Li XS, Graubard BI, Albanes D, Weinstein SJ, Goedert JJ, Wang Z, Hazen SL, Sinha R. Serum Trimethylamine N-oxide, Carnitine, Choline and Betaine in Relation to Colorectal Cancer Risk in the Alpha Tocopherol and Beta Carotene Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 28077427 DOI: 10.1158/1055-9965.EPI-16-0948  0.52
2017 Lin H, Levison BS, Buffa JA, Huang Y, Fu X, Wang Z, Gogonea V, DiDonato JA, Hazen SL. Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo. Free Radical Biology & Medicine. PMID 28069522 DOI: 10.1016/j.freeradbiomed.2017.01.006  1
2016 Bergeron N, Williams PT, Lamendella R, Faghihnia N, Grube A, Li X, Wang Z, Knight R, Jansson JK, Hazen SL, Krauss RM. Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk. The British Journal of Nutrition. 1-10. PMID 27993177 DOI: 10.1017/S0007114516004165  0.52
2016 Skye SM, Hazen SL. Microbial Modulation of a Uremic Toxin. Cell Host & Microbe. 20: 691-692. PMID 27978427 DOI: 10.1016/j.chom.2016.11.005  0.32
2016 Tang WH, Wang Z, Li XS, Fan Y, Li DS, Wu Y, Hazen SL. Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus. Clinical Chemistry. PMID 27864387 DOI: 10.1373/clinchem.2016.263640  0.52
2016 Senthong V, Wang Z, Fan Y, Wu Y, Hazen SL, Tang WH. Trimethylamine N-Oxide and Mortality Risk in Patients With Peripheral Artery Disease. Journal of the American Heart Association. 5. PMID 27792653 DOI: 10.1161/JAHA.116.004237  0.52
2016 Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen LP, Nelson CP, Nikpay M, ... ... Hazen SL, et al. No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Scientific Reports. 6: 35278. PMID 27731410 DOI: 10.1038/srep35278  1
2016 Wang Z, DiDonato JA, Buffa JA, Comhair SA, Aronica MA, Dweik R, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL. Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. The Journal of Biological Chemistry. PMID 27587397 DOI: 10.1074/jbc.M116.750034  1
2016 Iqbal AJ, Barr TJ, Taylor L, McNeill E, Manmadhan A, Recio C, Carmineri A, Brodermann MH, White GE, Cooper D, DiDonato JA, Hazen SL, Channon KM, Greaves DR, Fisher EA. Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo. Elife. 5. PMID 27572261 DOI: 10.7554/eLife.15190  1
2016 Gulshan K, Brubaker GD, Conger H, Wang S, Zhang R, Hazen SL, Smith JD. PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where it Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly. Circulation Research. PMID 27514935 DOI: 10.1161/CIRCRESAHA.116.308856  1
2016 Tang WH, Hazen SL. Microbiome, trimethylamine N-oxide, and cardiometabolic disease. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27490453 DOI: 10.1016/j.trsl.2016.07.007  1
2016 Senthong V, Wang Z, Li XS, Fan Y, Wu Y, Wilson Tang WH, Hazen SL. Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort. Journal of the American Heart Association. 5. PMID 27287696 DOI: 10.1161/JAHA.115.002816  1
2016 Senthong V, Li XS, Hudec T, Coughlin J, Wu Y, Levison B, Wang Z, Hazen SL, Tang WH. Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden. Journal of the American College of Cardiology. 67: 2620-8. PMID 27256833 DOI: 10.1016/j.jacc.2016.03.546  1
2016 Paz Y Mar HL, Hazen SL, Tracy RP, Strohl KP, Auckley D, Bena J, Wang L, Walia HK, Patel SR, Mehra R. Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: the Sleep Apnea Stress Randomized Controlled Trial. Chest. PMID 26997243 DOI: 10.1016/j.chest.2016.03.002  1
2016 Tang WW, Hazen SL. Dietary metabolism, gut microbiota and acute heart failure. Heart (British Cardiac Society). PMID 26980719 DOI: 10.1136/heartjnl-2016-309268  1
2016 Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WH, DiDonato JA, ... ... Hazen SL, et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. PMID 26972052 DOI: 10.1016/j.cell.2016.02.011  1
2016 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, et al. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 12: e1005913. PMID 26934746 DOI: 10.1371/journal.pgen.1005913  0.52
2016 Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. Journal of the American Heart Association. 5. PMID 26903003 DOI: 10.1161/JAHA.115.002767  0.52
2016 Hammadah M, Brennan ML, Wu Y, Hazen SL, Tang WH. Usefulness of Relative Hypochromia in Risk Stratification for Nonanemic Patients With Chronic Heart Failure. The American Journal of Cardiology. PMID 26897638 DOI: 10.1016/j.amjcard.2016.01.023  0.44
2016 Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ, Budoff M, Jacobson LP, Post WS, Sears CL. Intestinal Microbiota-Produced Trimethylamine-N-oxide and its Association with Coronary Stenosis and HIV Serostatus. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 26825179 DOI: 10.1097/QAI.0000000000000937  1
2016 Hartiala JA, Tang WH, Wang Z, Crow AL, Stewart AF, Roberts R, McPherson R, Erdmann J, Willenborg C, Hazen SL, Allayee H. Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nature Communications. 7: 10558. PMID 26822151 DOI: 10.1038/ncomms10558  1
2016 Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL. A systematic investigation of structure/function requirements for the apolipoprotein A-I - lecithin cholesterol acyltransferase interaction loop of HDL. The Journal of Biological Chemistry. PMID 26797122 DOI: 10.1074/jbc.M115.696088  1
2016 Serban MC, Sahebkar A, Mikhailidis DP, Toth PP, Jones SR, Muntner P, Blaha MJ, Andrica F, Martin SS, Borza C, Lip GY, Ray KK, Rysz J, Hazen SL, Banach M. Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials. Scientific Reports. 6: 19188. PMID 26754058 DOI: 10.1038/srep19188  0.44
2016 Organ CL, Otsuka H, Bhushan S, Wang Z, Bradley J, Trivedi R, Polhemus DJ, Tang WH, Wu Y, Hazen SL, Lefer DJ. Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. Circulation. Heart Failure. 9: e002314. PMID 26699388 DOI: 10.1161/CIRCHEARTFAILURE.115.002314  0.44
2016 DeMartino T, Ghoul RE, Wang L, Bena J, Hazen SL, Tracy R, Patel SR, Auckley D, Mehra R. Oxidative stress and inflammation differentially elevated in objective versus habitual subjective reduced sleep duration in obstructive sleep apnea Sleep. 39: 1361-1369. DOI: 10.5665/sleep.5964  1
2015 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, et al. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 11: e1005711. PMID 26694027 DOI: 10.1371/journal.pgen.1005711  1
2015 Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, ... ... Hazen SL, et al. Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell. 163: 1585-95. PMID 26687352 DOI: 10.1016/j.cell.2015.11.055  0.44
2015 Levi L, Wang Z, Doud MK, Hazen SL, Noy N. Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5. Nature Communications. 6: 8794. PMID 26592976 DOI: 10.1038/ncomms9794  1
2015 Gu X, Huang Y, Levison BS, Gerstenecker G, DiDonato AJ, Hazen LB, Lee J, Gogonea V, DiDonato JA, Hazen SL. Identification of critical paraoxonase 1 residues involved in high density lipoprotein interaction. The Journal of Biological Chemistry. PMID 26567339 DOI: 10.1074/jbc.M115.678334  1
2015 Dheer R, Patterson J, Dudash M, Stachler EN, Bibby KJ, Stolz DB, Shiva S, Wang Z, Hazen SL, Barchowsky A, Stolz JF. Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism. Toxicology and Applied Pharmacology. PMID 26529668 DOI: 10.1016/j.taap.2015.10.020  1
2015 Tang WH, Hazen SL. Probiotic therapy to attenuate weight gain and trimethylamine-N-Oxide generation: A cautionary tale. Obesity (Silver Spring, Md.). PMID 26466332 DOI: 10.1002/oby.21250  1
2015 Allayee H, Hazen SL. Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circulation Research. 117: 750-4. PMID 26450886 DOI: 10.1161/CIRCRESAHA.115.307409  1
2015 Tang WH, Hazen SL. Reply: Trimethylamine-N-Oxide and Heart Failure. Journal of the American College of Cardiology. 66: 96-7. PMID 26139067 DOI: 10.1016/j.jacc.2014.12.080  1
2015 Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: Implications for Enzyme Maturation. The Journal of Biological Chemistry. PMID 26134567 DOI: 10.1074/jbc.M115.645515  1
2015 Verbrugge FH, Tang WH, Hazen SL. Protein carbamylation and cardiovascular disease. Kidney International. PMID 26061545 DOI: 10.1038/ki.2015.166  1
2015 Comhair SA, Grandon D, Khan A, Zhang R, Hazen SL, Erzurum SC. Coenzyme Q in asthma. American Journal of Respiratory and Critical Care Medicine. 191: 1336-8. PMID 26029840 DOI: 10.1164/rccm.201412-2259LE  1
2015 Ghosh S, Vivar J, Nelson CP, Willenborg C, Segrè AV, Mäkinen VP, Nikpay M, Erdmann J, Blankenberg S, O'Donnell C, März W, Laaksonen R, Stewart AF, Epstein SE, Shah SH, ... ... Hazen SL, et al. Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1712-22. PMID 25977570 DOI: 10.1161/ATVBAHA.115.305513  1
2015 Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, et al. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 4. PMID 25846707 DOI: 10.7554/eLife.06184  1
2015 Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Science Translational Medicine. 7: 276ra27. PMID 25717100 DOI: 10.1126/scitranslmed.3010525  1
2015 Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, ... ... Hazen SL, et al. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Reports. PMID 25600868 DOI: 10.1016/j.celrep.2014.12.036  1
2015 Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circulation Research. 116: 448-55. PMID 25599331 DOI: 10.1161/CIRCRESAHA.116.305360  1
2015 Brown JM, Hazen SL. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annual Review of Medicine. 66: 343-59. PMID 25587655 DOI: 10.1146/annurev-med-060513-093205  1
2015 Berisha SZ, Brubaker G, Kasumov T, Hung KT, DiBello PM, Huang Y, Li L, Willard B, Pollard KA, Nagy LE, Hazen SL, Smith JD. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function. Journal of Lipid Research. 56: 653-64. PMID 25561462 DOI: 10.1194/jlr.M056754  1
2015 Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Transmission of atherosclerosis susceptibility with gut microbial transplantation. The Journal of Biological Chemistry. 290: 5647-60. PMID 25550161 DOI: 10.1074/jbc.M114.618249  1
2015 Cowan DC, Taylor DR, Peterson LE, Cowan JO, Palmay R, Williamson A, Hammel J, Erzurum SC, Hazen SL, Comhair SA. Biomarker-based asthma phenotypes of corticosteroid response. The Journal of Allergy and Clinical Immunology. 135: 877-83.e1. PMID 25488689 DOI: 10.1016/j.jaci.2014.10.026  1
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Hazen SL, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/nature13917  1
2015 Tang WH, Wang Z, Shrestha K, Borowski AG, Wu Y, Troughton RW, Klein AL, Hazen SL. Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. Journal of Cardiac Failure. 21: 91-6. PMID 25459686 DOI: 10.1016/j.cardfail.2014.11.006  1
2015 Grodin JL, Neale S, Wu Y, Hazen SL, Tang WH. Prognostic comparison of different sensitivity cardiac troponin assays in stable heart failure. The American Journal of Medicine. 128: 276-82. PMID 25447612 DOI: 10.1016/j.amjmed.2014.09.029  1
2015 Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. Journal of Lipid Research. 56: 22-37. PMID 25378658 DOI: 10.1194/jlr.M051680  1
2015 Grodin JL, Hammadah M, Fan Y, Hazen SL, Tang WH. Prognostic value of estimating functional capacity with the use of the duke activity status index in stable patients with chronic heart failure. Journal of Cardiac Failure. 21: 44-50. PMID 25175697 DOI: 10.1016/j.cardfail.2014.08.013  1
2015 Alkhouri N, Eng K, Cikach F, Patel N, Yan C, Brindle A, Rome E, Hanouneh I, Grove D, Lopez R, Hazen SL, Dweik RA. Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls. Pediatric Obesity. 10: 23-9. PMID 24677760 DOI: 10.1111/j.2047-6310.2014.221.x  1
2015 Mani P, Uno K, St. John J, Kupfer S, Perez A, Tuzcu EM, Hazen SL, Nissen SE, Nicholls SJ. Favorable Impact on LDL Particle Size in Response to Treatment with Pioglitazone is Associated with Less Progression of Coronary Atherosclerosis in Patients with Type 2 Diabetes Journal of the American College of Cardiology. 66: 328-329. DOI: 10.1016/j.jacc.2015.05.023  1
2014 Tang WH, Wang Z, Fan Y, Levison B, Hazen JE, Donahue LM, Wu Y, Hazen SL. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. Journal of the American College of Cardiology. 64: 1908-14. PMID 25444145 DOI: 10.1016/j.jacc.2014.02.617  1
2014 Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metabolism. 20: 799-812. PMID 25440057 DOI: 10.1016/j.cmet.2014.10.006  1
2014 Jia J, Arif A, Terenzi F, Willard B, Plow EF, Hazen SL, Fox PL. Target-selective protein S-nitrosylation by sequence motif recognition. Cell. 159: 623-34. PMID 25417112 DOI: 10.1016/j.cell.2014.09.032  1
2014 Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, ... ... Hazen SL, et al. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. The Journal of Clinical Investigation. 124: 5159-74. PMID 25401476 DOI: 10.1172/JCI77484  1
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Hazen SL, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/NEJMoa1405386  1
2014 Tang WH, Topol EJ, Fan Y, Wu Y, Cho L, Stevenson C, Ellis SG, Hazen SL. Prognostic value of estimated functional capacity incremental to cardiac biomarkers in stable cardiac patients. Journal of the American Heart Association. 3: e000960. PMID 25332177 DOI: 10.1161/JAHA.114.000960  1
2014 Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovascular disease. The Journal of Clinical Investigation. 124: 4204-11. PMID 25271725 DOI: 10.1172/JCI72331  1
2014 Soloviev DA, Hazen SL, Szpak D, Bledzka KM, Ballantyne CM, Plow EF, Pluskota E. Dual role of the leukocyte integrin αMβ2 in angiogenesis. Journal of Immunology (Baltimore, Md. : 1950). 193: 4712-21. PMID 25261488 DOI: 10.4049/jimmunol.1400202  1
2014 Hammadah M, Fan Y, Wu Y, Hazen SL, Tang WH. Prognostic value of elevated serum ceruloplasmin levels in patients with heart failure. Journal of Cardiac Failure. 20: 946-52. PMID 25128745 DOI: 10.1016/j.cardfail.2014.08.001  1
2014 Hazen SL, Brown JM. Eggs as a dietary source for gut microbial production of trimethylamine-N-oxide. The American Journal of Clinical Nutrition. 100: 741-3. PMID 25080455 DOI: 10.3945/ajcn.114.094458  1
2014 Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, ... ... Hazen SL, et al. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. Plos Genetics. 10: e1004502. PMID 25033284 DOI: 10.1371/journal.pgen.1004502  1
2014 Shao Z, Zhang R, Shrestha K, Borowski AG, Schuster A, Thakur A, Hazen SL, Tang WH. Usefulness of elevated urine neopterin levels in assessing cardiac dysfunction and exercise ventilation inefficiency in patients with chronic systolic heart failure. The American Journal of Cardiology. 113: 1839-43. PMID 24837262 DOI: 10.1016/j.amjcard.2014.03.016  1
2014 Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, et al. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. The Journal of Experimental Medicine. 211: 887-907. PMID 24752299 DOI: 10.1084/jem.20131314  1
2014 Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, ... ... Hazen SL, et al. Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression. Stem Cells (Dayton, Ohio). 32: 1746-58. PMID 24737733 DOI: 10.1002/stem.1716  1
2014 Wang Z, Levison BS, Hazen JE, Donahue L, Li XM, Hazen SL. Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Analytical Biochemistry. 455: 35-40. PMID 24704102 DOI: 10.1016/j.ab.2014.03.016  1
2014 Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R, Lusis AJ, Hazen SL, Allayee H. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1307-13. PMID 24675659 DOI: 10.1161/ATVBAHA.114.303252  1
2014 Brown JM, Hazen SL. Seeking a unique lipid signature predicting cardiovascular disease risk. Circulation. 129: 1799-803. PMID 24622383 DOI: 10.1161/CIRCULATIONAHA.114.009224  1
2014 DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL. Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. The Journal of Biological Chemistry. 289: 10276-92. PMID 24558038 DOI: 10.1074/jbc.M114.556506  1
2014 Wang Z, Tang WH, Buffa JA, Fu X, Britt EB, Koeth RA, Levison BS, Fan Y, Wu Y, Hazen SL. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. European Heart Journal. 35: 904-10. PMID 24497336 DOI: 10.1093/eurheartj/ehu002  1
2014 Kataoka Y, Shao M, Wolski K, Uno K, Puri R, Murat Tuzcu E, Hazen SL, Nissen SE, Nicholls SJ. Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: Insights from intravascular ultrasound Atherosclerosis. 232: 377-383. PMID 24468151 DOI: 10.1016/j.atherosclerosis.2013.11.075  1
2014 Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL. OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease. Digestive Diseases and Sciences. 59: 1617-24. PMID 24464211 DOI: 10.1007/s10620-014-3031-8  1
2014 Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, ... ... Hazen SL, et al. An abundant dysfunctional apolipoprotein A1 in human atheroma. Nature Medicine. 20: 193-203. PMID 24464187 DOI: 10.1038/nm.3459  1
2014 Hewing B, Parathath S, Barrett T, Chung WK, Astudillo YM, Hamada T, Ramkhelawon B, Tallant TC, Yusufishaq MS, Didonato JA, Huang Y, Buffa J, Berisha SZ, Smith JD, Hazen SL, et al. Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 779-89. PMID 24407029 DOI: 10.1161/ATVBAHA.113.303044  1
2014 Raymond C, Cho L, Rocco M, Hazen SL. New cholesterol guidelines: worth the wait? Cleveland Clinic Journal of Medicine. 81: 11-9. PMID 24391101 DOI: 10.3949/ccjm.81a.13161  1
2014 Feig JE, Hewing B, Smith JD, Hazen SL, Fisher EA. High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies. Circulation Research. 114: 205-13. PMID 24385513 DOI: 10.1161/CIRCRESAHA.114.300760  1
2014 Brown JM, Hazen SL. Metaorganismal nutrient metabolism as a basis of cardiovascular disease. Current Opinion in Lipidology. 25: 48-53. PMID 24362355 DOI: 10.1097/MOL.0000000000000036  1
2014 Christian AJ, Lin H, Alferiev IS, Connolly JM, Ferrari G, Hazen SL, Ischiropoulos H, Levy RJ. The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials. 35: 2097-102. PMID 24360721 DOI: 10.1016/j.biomaterials.2013.11.045  1
2014 Fabbrini E, Serafini M, Colic Baric I, Hazen SL, Klein S. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes. 63: 976-81. PMID 24353177 DOI: 10.2337/db13-1396  1
2014 Kennedy DJ, Fan Y, Wu Y, Pepoy M, Hazen SL, Tang WH. Plasma ceruloplasmin, a regulator of nitric oxide activity, and incident cardiovascular risk in patients with CKD. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 462-7. PMID 24311705 DOI: 10.2215/CJN.07720713  1
2014 Vinjé S, Stroes E, Nieuwdorp M, Hazen SL. The gut microbiome as novel cardio-metabolic target: The time has come! European Heart Journal. 35: 883-887. PMID 24216389 DOI: 10.1093/eurheartj/eht467  1
2014 Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, et al. Correction to MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases [J. Exp. Med., 211, 5, (2014) 887-907] Journal of Experimental Medicine. 211: 1003. DOI: 10.1084/jem.2013131404222014c  1
2013 Gulshan K, Brubaker G, Wang S, Hazen SL, Smith JD. Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux. The Journal of Biological Chemistry. 288: 37166-79. PMID 24220029 DOI: 10.1074/jbc.M113.512244  1
2013 Mampuya WM, Frid D, Rocco M, Huang J, Brennan DM, Hazen SL, Cho L. Treatment strategies in patients with statin intolerance: the Cleveland Clinic experience. American Heart Journal. 166: 597-603. PMID 24016512 DOI: 10.1016/j.ahj.2013.06.004  1
2013 DiDonato JA, Huang Y, Aulak KS, Even-Or O, Gerstenecker G, Gogonea V, Wu Y, Fox PL, Tang WH, Plow EF, Smith JD, Fisher EA, Hazen SL. Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma. Circulation. 128: 1644-55. PMID 23969698 DOI: 10.1161/CIRCULATIONAHA.113.002624  1
2013 Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, ... ... Hazen SL, et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. The Journal of Clinical Investigation. 123: 3815-28. PMID 23908111 DOI: 10.1172/JCI67478  1
2013 Pluskota E, Ma Y, Bledzka KM, Bialkowska K, Soloviev DA, Szpak D, Podrez EA, Fox PL, Hazen SL, Dowling JJ, Ma YQ, Plow EF. Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism. Blood. 122: 2491-9. PMID 23896409 DOI: 10.1182/blood-2013-04-497669  1
2013 Dadu RT, Dodge R, Nambi V, Virani SS, Hoogeveen RC, Smith NL, Chen F, Pankow JS, Guild C, Tang WH, Boerwinkle E, Hazen SL, Ballantyne CM. Ceruloplasmin and heart failure in the Atherosclerosis Risk in Communities study. Circulation. Heart Failure. 6: 936-43. PMID 23861484 DOI: 10.1161/CIRCHEARTFAILURE.113.000270  1
2013 Kasumov T, Willard B, Li L, Li M, Conger H, Buffa JA, Previs S, McCullough A, Hazen SL, Smith JD. 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1994-2003. PMID 23766259 DOI: 10.1161/ATVBAHA.113.301700  1
2013 Fan M, Dandona S, McPherson R, Allayee H, Hazen SL, Wells GA, Roberts R, Stewart AF. Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circulation. Cardiovascular Genetics. 6: 372-80. PMID 23729007 DOI: 10.1161/CIRCGENETICS.113.000104  1
2013 Zamanian-Daryoush M, Lindner D, Tallant TC, Wang Z, Buffa J, Klipfell E, Parker Y, Hatala D, Parsons-Wingerter P, Rayman P, Yusufishaq MS, Fisher EA, Smith JD, Finke J, DiDonato JA, ... Hazen SL, et al. The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. The Journal of Biological Chemistry. 288: 21237-52. PMID 23720750 DOI: 10.1074/jbc.M113.468967  1
2013 Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, ... ... Hazen SL, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Human Molecular Genetics. 22: 3381-93. PMID 23620142 DOI: 10.1093/hmg/ddt189  1
2013 Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. The New England Journal of Medicine. 368: 1575-84. PMID 23614584 DOI: 10.1056/NEJMoa1109400  1
2013 Tang WH, Shrestha K, Wang Z, Borowski AG, Troughton RW, Klein AL, Hazen SL. Protein carbamylation in chronic systolic heart failure: relationship with renal impairment and adverse long-term outcomes. Journal of Cardiac Failure. 19: 219-24. PMID 23582087 DOI: 10.1016/j.cardfail.2013.02.001  1
2013 Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, ... ... Hazen SL, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. 19: 576-85. PMID 23563705 DOI: 10.1038/nm.3145  1
2013 Wang S, Gulshan K, Brubaker G, Hazen SL, Smith JD. ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1197-205. PMID 23559627 DOI: 10.1161/ATVBAHA.112.301195  1
2013 Kennedy DJ, Tang WH, Fan Y, Wu Y, Mann S, Pepoy M, Hazen SL. Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease. Journal of the American Heart Association. 2: e000104. PMID 23557751 DOI: 10.1161/JAHA.112.000104  1
2013 Li XM, Tang WH, Mosior MK, Huang Y, Wu Y, Matter W, Gao V, Schmitt D, Didonato JA, Fisher EA, Smith JD, Hazen SL. Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1696-705. PMID 23520163 DOI: 10.1161/ATVBAHA.113.301373  1
2013 Zhou G, Marathe GK, Hartiala J, Hazen SL, Allayee H, Tang WH, McIntyre TM. Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2). The Journal of Biological Chemistry. 288: 11940-8. PMID 23508960 DOI: 10.1074/jbc.M112.427674  1
2013 Levison BS, Zhang R, Wang Z, Fu X, DiDonato JA, Hazen SL. Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry. Free Radical Biology & Medicine. 59: 2-13. PMID 23499838 DOI: 10.1016/j.freeradbiomed.2013.03.001  1
2013 Tang WH, Shrestha K, Tong W, Wang Z, Troughton RW, Borowski AG, Klein AL, Hazen SL. Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction. Translational Research : the Journal of Laboratory and Clinical Medicine. 162: 26-33. PMID 23499315 DOI: 10.1016/j.trsl.2013.02.005  1
2013 Koeth RA, Kalantar-Zadeh K, Wang Z, Fu X, Tang WH, Hazen SL. Protein carbamylation predicts mortality in ESRD. Journal of the American Society of Nephrology : Jasn. 24: 853-61. PMID 23431074 DOI: 10.1681/ASN.2012030254  1
2013 Tang WH, Wu Y, Britt EB, Iqbal N, Hazen SL. Detectable subclinical myocardial necrosis is associated with cardiovascular risk in stable patients with diabetes. Diabetes Care. 36: 1126-31. PMID 23393213 DOI: 10.2337/dc11-1969  1
2013 Tang WH, Shrestha K, Wang Z, Troughton RW, Klein AL, Hazen SL. Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure. Journal of Cardiac Failure. 19: 87-93. PMID 23384633 DOI: 10.1016/j.cardfail.2013.01.001  1
2013 Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, ... ... Hazen SL, et al. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. Journal of the American College of Cardiology. 61: 957-70. PMID 23352782 DOI: 10.1016/j.jacc.2012.10.051  1
2013 Gogonea V, Gerstenecker GS, Wu Z, Lee X, Topbas C, Wagner MA, Tallant TC, Smith JD, Callow P, Pipich V, Malet H, Schoehn G, DiDonato JA, Hazen SL. The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion. Journal of Lipid Research. 54: 966-83. PMID 23349207 DOI: 10.1194/jlr.M032763  1
2013 Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metabolism. 17: 49-60. PMID 23312283 DOI: 10.1016/j.cmet.2012.12.011  1
2013 Tang WH, Iqbal N, Wu Y, Hazen SL. Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status. The American Journal of Cardiology. 111: 465-70. PMID 23219176 DOI: 10.1016/j.amjcard.2012.10.027  1
2013 Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, et al. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. American Journal of Respiratory and Critical Care Medicine. 187: 153-9. PMID 23204252 DOI: 10.1164/rccm.201207-1270OC  1
2013 Bakhautdin B, Febbraio M, Goksoy E, de la Motte CA, Gulen MF, Childers EP, Hazen SL, Li X, Fox PL. Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease. Gut. 62: 209-19. PMID 22345661 DOI: 10.1136/gutjnl-2011-300694  1
2012 Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD. High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2813-20. PMID 23152494 DOI: 10.1161/ATVBAHA.112.300133  1
2012 Thomson L, Tenopoulou M, Lightfoot R, Tsika E, Parastatidis I, Martinez M, Greco TM, Doulias PT, Wu Y, Tang WH, Hazen SL, Ischiropoulos H. Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease. Circulation. 126: 2392-401. PMID 23081989 DOI: 10.1161/CIRCULATIONAHA.112.103796  1
2012 Hazen SL, Smith JD. An antiatherosclerotic signaling cascade involving intestinal microbiota, microRNA-10b, and ABCA1/ABCG1-mediated reverse cholesterol transport. Circulation Research. 111: 948-50. PMID 23023503 DOI: 10.1161/CIRCRESAHA.112.277277  1
2012 Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 3066-75. PMID 23023370 DOI: 10.1161/ATVBAHA.112.255711  1
2012 Tang WH, Hartiala J, Fan Y, Wu Y, Stewart AF, Erdmann J, Kathiresan S, Roberts R, McPherson R, Allayee H, Hazen SL. Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2803-12. PMID 22982463 DOI: 10.1161/ATVBAHA.112.253930  1
2012 Dupont M, Wu Y, Hazen SL, Tang WH. Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events. Circulation. Heart Failure. 5: 602-9. PMID 22899766 DOI: 10.1161/CIRCHEARTFAILURE.112.966960  1
2012 Qiu J, Tsien C, Thapalaya S, Narayanan A, Weihl CC, Ching JK, Eghtesad B, Singh K, Fu X, Dubyak G, McDonald C, Almasan A, Hazen SL, Naga Prasad SV, Dasarathy S. Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. American Journal of Physiology. Endocrinology and Metabolism. 303: E983-93. PMID 22895779 DOI: 10.1152/ajpendo.00183.2012  1
2012 Senn T, Hazen SL, Tang WHW. Translating Metabolomics to Cardiovascular Biomarkers Progress in Cardiovascular Diseases. 55: 70-76. PMID 22824112 DOI: 10.1016/j.pcad.2012.06.004  1
2012 Jia J, Arif A, Willard B, Smith JD, Stuehr DJ, Hazen SL, Fox PL. Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Molecular Cell. 47: 656-63. PMID 22771119 DOI: 10.1016/j.molcel.2012.06.006  1
2012 Patel RS, Sun YV, Hartiala J, Veledar E, Su S, Sher S, Liu YX, Rahman A, Patel R, Rab ST, Vaccarino V, Zafari AM, Samady H, Tang WH, Allayee H, ... Hazen SL, et al. Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circulation. Cardiovascular Genetics. 5: 441-9. PMID 22767652 DOI: 10.1161/CIRCGENETICS.111.960229  1
2012 Hazen SL. New lipid and lipoprotein targets for the treatment of cardiometabolic diseases Journal of Lipid Research. 53: 1719-1721. PMID 22766886 DOI: 10.1194/jlr.E030205  1
2012 Asosingh K, Farha S, Lichtin A, Graham B, George D, Aldred M, Hazen SL, Loyd J, Tuder R, Erzurum SC. Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension. Blood. 120: 1218-27. PMID 22745307 DOI: 10.1182/blood-2012-03-419275  1
2012 Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergräber OH. Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain. Acta Crystallographica. Section D, Biological Crystallography. 68: 686-94. PMID 22683791 DOI: 10.1107/S0907444912008372  1
2012 Martinez M, Cuker A, Mills A, Lightfoot R, Fan Y, Tang WH, Hazen SL, Ischiropoulos H. Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radical Biology & Medicine. 53: 230-6. PMID 22580301 DOI: 10.1016/j.freeradbiomed.2012.05.004  1
2012 Zein CO, Lopez R, Fu X, Kirwan JP, Yerian LM, McCullough AJ, Hazen SL, Feldstein AE. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology (Baltimore, Md.). 56: 1291-9. PMID 22505276 DOI: 10.1002/hep.25778  1
2012 Ellis SG, Dushman-Ellis S, Luke MM, Murugesan G, Kottke-Marchant K, Ellis GM, Griffin B, Tuzcu EM, Hazen S. Pilot candidate gene analysis of patients ≥ 60 years old with aortic stenosis involving a tricuspid aortic valve. The American Journal of Cardiology. 110: 88-92. PMID 22483387 DOI: 10.1016/j.amjcard.2012.02.053  1
2012 Shao Z, Wang Z, Shrestha K, Thakur A, Borowski AG, Sweet W, Thomas JD, Moravec CS, Hazen SL, Tang WH. Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1. Journal of the American College of Cardiology. 59: 1150-8. PMID 22440215 DOI: 10.1016/j.jacc.2011.12.022  1
2012 Suzuki M, Tsujikawa M, Itabe H, Du ZJ, Xie P, Matsumura N, Fu X, Zhang R, Sonoda KH, Egashira K, Hazen SL, Kamei M. Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration. Journal of Cell Science. 125: 2407-15. PMID 22357958 DOI: 10.1242/jcs.097683  1
2012 Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, König IR, ... ... Hazen SL, et al. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circulation. Cardiovascular Genetics. 5: 217-25. PMID 22319020 DOI: 10.1161/CIRCGENETICS.111.961243  1
2012 Tang WH, Wu Y, Hartiala J, Fan Y, Stewart AF, Roberts R, McPherson R, Fox PL, Allayee H, Hazen SL. Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 516-22. PMID 22075249 DOI: 10.1161/ATVBAHA.111.237040  1
2012 Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, Khuseyinova N, Schnabel RB, Rice KM, Rivadeneira F, Hoogeveen RC, ... ... Hazen SL, et al. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. European Heart Journal. 33: 238-51. PMID 22003152 DOI: 10.1093/eurheartj/ehr372  1
2012 Heresi GA, Tang WH, Aytekin M, Hammel J, Hazen SL, Dweik RA. Sensitive cardiac troponin I predicts poor outcomes in pulmonary arterial hypertension. The European Respiratory Journal. 39: 939-44. PMID 21885398 DOI: 10.1183/09031936.00067011  1
2011 Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, März W, Winkelmann BR, Boehm BO, et al. Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. Bmc Medical Genetics. 12: 127. PMID 21957892 DOI: 10.1186/1471-2350-12-127  1
2011 Nicholls SJ, Tang WH, Brennan D, Brennan ML, Mann S, Nissen SE, Hazen SL. Risk prediction with serial myeloperoxidase monitoring in patients with acute chest pain. Clinical Chemistry. 57: 1762-70. PMID 21940659 DOI: 10.1373/clinchem.2011.166827  1
2011 Appachi S, Kelly KR, Schauer PR, Kirwan JP, Hazen S, Gupta M, Kashyap SR. Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy". Obesity Surgery. 21: 1928-36. PMID 21625910 DOI: 10.1007/s11695-011-0447-5  1
2011 Comhair SA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Teague WG, Meyers D, Ampleford EJ, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, ... ... Hazen SL, et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. Plos One. 6: e18574. PMID 21572527 DOI: 10.1371/journal.pone.0018574  1
2011 Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, ... ... Hazen SL, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472: 57-63. PMID 21475195 DOI: 10.1038/nature09922  1
2011 Wedes SH, Wu W, Comhair SA, McDowell KM, DiDonato JA, Erzurum SC, Hazen SL. Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. The Journal of Pediatrics. 159: 248-55.e1. PMID 21392781 DOI: 10.1016/j.jpeds.2011.01.029  1
2011 Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, ... ... Hazen SL, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43: 333-8. PMID 21378990 DOI: 10.1038/ng.784  1
2011 Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, ... ... Hazen SL, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. Plos Genetics. 7: e1001300. PMID 21347282 DOI: 10.1371/journal.pgen.1001300  1
2011 Hartiala J, Li D, Conti DV, Vikman S, Patel Y, Tang WH, Brennan ML, Newman JW, Stephensen CB, Armstrong P, Hazen SL, Allayee H. Genetic contribution of the leukotriene pathway to coronary artery disease. Human Genetics. 129: 617-27. PMID 21293878 DOI: 10.1007/s00439-011-0963-3  1
2011 Wu Z, Gogonea V, Lee X, May RP, Pipich V, Wagner MA, Undurti A, Tallant TC, Baleanu-Gogonea C, Charlton F, Ioffe A, DiDonato JA, Rye KA, Hazen SL. The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering. The Journal of Biological Chemistry. 286: 12495-508. PMID 21292766 DOI: 10.1074/jbc.M110.209130  1
2011 Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, ... ... Hazen SL, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 377: 383-92. PMID 21239051 DOI: 10.1016/S0140-6736(10)61996-4  1
2011 Becker RC, Mahaffey KW, Yang H, Marian AJ, Furman MI, Michael Lincoff A, Hazen SL, Petersen JL, Reist CJ, Kleiman NS. Heparin-associated anti-Xa activity and platelet-derived prothrombotic and proinflammatory biomarkers in moderate to high-risk patients with acute coronary syndrome. Journal of Thrombosis and Thrombolysis. 31: 146-53. PMID 21086021 DOI: 10.1007/s11239-010-0532-y  1
2011 Tang WH, Wu Y, Mann S, Pepoy M, Shrestha K, Borowski AG, Hazen SL. Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure. Circulation. Heart Failure. 4: 59-64. PMID 21062973 DOI: 10.1161/CIRCHEARTFAILURE.110.958348  1
2011 Tang WH, Wu Y, Nicholls SJ, Hazen SL. Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease. Clinical Chemistry. 57: 33-9. PMID 21059827 DOI: 10.1373/clinchem.2010.152827  1
2010 McIntyre TM, Hazen SL. Lipid oxidation and cardiovascular disease: introduction to a review series. Circulation Research. 107: 1167-9. PMID 21071714 DOI: 10.1161/CIRCRESAHA.110.224618  1
2010 Hazen SL. Neutrophils, hypercholesterolemia, and atherogenesis Circulation. 122: 1786-1788. PMID 20956213 DOI: 10.1161/CIRCULATIONAHA.110.984062  1
2010 Davies RW, Dandona S, Stewart AFR, Chen L, Ellis SG, Tang WHW, Hazen SL, Roberts R, McPherson R, Wells GA. Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies Circulation: Cardiovascular Genetics. 3: 468-474. PMID 20729558 DOI: 10.1161/CIRCGENETICS.110.946269  1
2010 Robinet P, Wang Z, Hazen SL, Smith JD. A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells Journal of Lipid Research. 51: 3364-3369. PMID 20688754 DOI: 10.1194/jlr.D007336  1
2010 Gogonea V, Wu Z, Lee X, Pipich V, Li XM, Ioffe AI, Didonato JA, Hazen SL. Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double-super helix model of nascent high-density lipoprotein. Biochemistry. 49: 7323-43. PMID 20687589 DOI: 10.1021/bi100588a  1
2010 Feldstein AE, Lopez R, Tamimi TA, Yerian L, Chung YM, Berk M, Zhang R, McIntyre TM, Hazen SL. Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Journal of Lipid Research. 51: 3046-54. PMID 20631297 DOI: 10.1194/jlr.M007096  1
2010 Nicholls SJ, Tang WH, Scoffone H, Brennan DM, Hartiala J, Allayee H, Hazen SL. Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. Journal of Lipid Research. 51: 3055-61. PMID 20601648 DOI: 10.1194/jlr.M008961  1
2010 Brennan ML, Reddy A, Tang WH, Wu Y, Brennan DM, Hsu A, Mann SA, Hammer PL, Hazen SL. Comprehensive peroxidase-based hematologic profiling for the prediction of 1-year myocardial infarction and death. Circulation. 122: 70-9. PMID 20566956 DOI: 10.1161/CIRCULATIONAHA.109.881581  1
2010 Nasca MM, Zhang R, Super DM, Hazen SL, Hall HR. Increased oxidative stress in healthy children following an exercise program: a pilot study. Journal of Developmental and Behavioral Pediatrics : Jdbp. 31: 386-92. PMID 20495476 DOI: 10.1097/DBP.0b013e3181dea44f  1
2010 Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, Bokarewa M. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. Journal of Immunology (Baltimore, Md. : 1950). 184: 6882-90. PMID 20488785 DOI: 10.4049/jimmunol.1000075  1
2010 Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, Von Leitner EC, Szoecs K, ... ... Hazen SL, et al. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation Nature Medicine. 16: 470-474. PMID 20305660 DOI: 10.1038/nm.2124  1
2010 Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, ... ... Hazen SL, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nature Genetics. 42: 240-4. PMID 20173747 DOI: 10.1038/ng.537  1
2010 Vogel JP, Garvin DF, Mockler TC, Schmutz J, Rokhsar D, Bevan MW, Barry K, Lucas S, Harmon-Smith M, Lail K, Tice H, Grimwood J, McKenzie N, Huo N, Gu YQ, ... ... Hazen SP, et al. Genome sequencing and analysis of the model grass Brachypodium distachyon Nature. 463: 763-768. PMID 20148030 DOI: 10.1038/nature08747  1
2010 Hazen S. HDL structure, function, therapeutics, and imaging Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 138. PMID 20089949 DOI: 10.1161/ATVBAHA.109.201897  1
2010 Thomas CP, Morgan LT, Maskrey BH, Murphy RC, Kühn H, Hazen SL, Goodall AH, Hamali HA, Collins PW, O'Donnell VB. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. The Journal of Biological Chemistry. 285: 6891-903. PMID 20061396 DOI: 10.1074/jbc.M109.078428  1
2010 Tang WH, Wu Y, Nicholls SJ, Brennan DM, Pepoy M, Mann S, Pratt A, Van Lente F, Hazen SL. Subclinical myocardial necrosis and cardiovascular risk in stable patients undergoing elective cardiac evaluation. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 634-40. PMID 20032289 DOI: 10.1161/ATVBAHA.109.201210  1
2010 Provencio JJ, Fu X, Siu A, Rasmussen PA, Hazen SL, Ransohoff RM. CSF neutrophils are implicated in the development of vasospasm in subarachnoid hemorrhage Neurocritical Care. 12: 244-251. PMID 19967568 DOI: 10.1007/s12028-009-9308-7  1
2010 Dandona S, Chen L, Fan M, Alam MA, Assogba O, Belanger M, Williams K, Wells GA, Tang WHW, Ellis SG, Hazen SL, McPherson R, Roberts R, Stewart AFR. The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa heart genomics and Cleveland clinic genebank studies Human Genetics. 127: 101-105. PMID 19885677 DOI: 10.1007/s00439-009-0761-3  1
2009 Wedes SH, Khatri SB, Zhang R, Wu W, Comhair SA, Wenzel S, Teague WG, Israel E, Erzurum SC, Hazen SL. Noninvasive markers of airway inflammation in asthma. Clinical and Translational Science. 2: 112-7. PMID 20234847 DOI: 10.1111/j.1752-8062.2009.00095.x  1
2009 Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL. Double superhelix model of high density lipoprotein. The Journal of Biological Chemistry. 284: 36605-19. PMID 19812036 DOI: 10.1074/jbc.M109.039537  1
2009 Undurti A, Huang Y, Lupica JA, Smith JD, DiDonato JA, Hazen SL. Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. The Journal of Biological Chemistry. 284: 30825-35. PMID 19726691 DOI: 10.1074/jbc.M109.047605  1
2009 Wang Z, Tang WHW, Cho L, Brennan DM, Hazen SL. Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: Potential mechanisms beyond nitric oxide synthase inhibition Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1383-1391. PMID 19542023 DOI: 10.1161/ATVBAHA.109.185645  1
2009 Tang WHW, Wang Z, Cho L, Brennan DM, Hazen SL. Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk Journal of the American College of Cardiology. 53: 2061-2067. PMID 19477356 DOI: 10.1016/j.jacc.2009.02.036  1
2009 Tang WH, Katz R, Brennan ML, Aviles RJ, Tracy RP, Psaty BM, Hazen SL. Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure. The American Journal of Cardiology. 103: 1269-74. PMID 19406270 DOI: 10.1016/j.amjcard.2009.01.026  1
2009 Kashyap SR, Diab DL, Baker AR, Yerian L, Bajaj H, Gray-McGuire C, Schauer PR, Gupta M, Feldstein AE, Hazen SL, Stein CM. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring, Md.). 17: 1696-701. PMID 19360015 DOI: 10.1038/oby.2009.89  1
2009 Kato GJ, Wang Z, MacHado RF, Blackwelder WC, Taylor VI JG, Hazen SL. Endogenous nitric oxide synthase inhibitors in sickle cell disease: Abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death British Journal of Haematology. 145: 506-513. PMID 19344390 DOI: 10.1111/j.1365-2141.2009.07658.x  1
2009 Zhou X, Wang H, Wang J, Wang Y, Hoehn G, Azok J, Brennan ML, Hazen SL, Li K, Chang SF, Wong ST. Identification of biomarkers for risk stratification of cardiovascular events using genetic algorithm with recursive local floating search. Proteomics. 9: 2286-94. PMID 19337989 DOI: 10.1002/pmic.200700867  1
2009 Shishehbor MH, Hazen SL. JUPITER to earth: A statin helps people with normal LDL-C and high hs-CRP, but what does it mean? Cleveland Clinic Journal of Medicine. 76: 37-44. PMID 19122109 DOI: 10.3949/ccjm.75a.08105  1
2009 Nicholls SJ, Hazen SL. Myeloperoxidase, modified lipoproteins, and atherogenesis Journal of Lipid Research. 50. PMID 19091698 DOI: 10.1194/jlr.R800086-JLR200  1
2008 Tang WH, Tong W, Shrestha K, Wang Z, Levison BS, Delfraino B, Hu B, Troughton RW, Klein AL, Hazen SL. Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure. European Heart Journal. 29: 2506-13. PMID 18687662 DOI: 10.1093/eurheartj/ehn360  0.72
2008 El-Bejjani D, Hazen SL, Mackay W, Glass NE, Hulgan T, Tungsiripat M, McComsey GA. Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults. Hiv Clinical Trials. 9: 207-11. PMID 18547908 DOI: 10.1310/hct0903-207  1
2008 Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. Jama. 299: 1265-76. PMID 18349088 DOI: 10.1001/jama.299.11.1265  1
2008 Morrow DA, Sabatine MS, Brennan ML, de Lemos JA, Murphy SA, Ruff CT, Rifai N, Cannon CP, Hazen SL. Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18. European Heart Journal. 29: 1096-102. PMID 18339606 DOI: 10.1093/eurheartj/ehn071  1
2007 Nicholls SJ, Wang Z, Koeth R, Levison B, Delfraino B, Dzavik V, Griffith OW, Hathaway D, Panza JA, Nissen SE, Hochman JS, Hazen SL. Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction Circulation. 116: 2315-2324. PMID 17967979 DOI: 10.1161/CIRCULATIONAHA.107.693986  1
2007 Shen GQ, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y, Olivieri O, Marchant K, Barnard J, Corrocher R, Elston R, ... ... Hazen SL, et al. An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. American Journal of Human Genetics. 81: 780-91. PMID 17847002 DOI: 10.1086/521581  1
2007 Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature Medicine. 13: 1176-84. PMID 17828273 DOI: 10.1038/nm1637  1
2007 Bhatt DL, Chew DP, Grines C, Mukherjee D, Leesar M, Gilchrist IC, Corbelli JC, Blankenship JC, Eres A, Steinhubl S, Tan WA, Resar JR, AlMahameed A, Abdel-Latif A, Tang HW, ... ... Hazen SL, et al. Peroxisome proliferator-activated receptor γ agonists for the Prevention of Adverse events following percutaneous coronary Revascularization-results of the PPAR Study American Heart Journal. 154: 137-143. PMID 17584566 DOI: 10.1016/j.ahj.2007.03.029  1
2007 Dzavík V, Cotter G, Reynolds HR, Alexander JH, Ramanathan K, Stebbins AL, Hathaway D, Farkouh ME, Ohman EM, Baran DA, Prondzinsky R, Panza JA, Cantor WJ, Vered Z, Buller CE, ... ... Hazen SL, et al. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. European Heart Journal. 28: 1109-16. PMID 17459901 DOI: 10.1093/eurheartj/ehm075  1
2007 Blum S, Asaf R, Guetta J, Miller-Lotan R, Asleh R, Kremer R, Levy NS, Berger FG, Aronson D, Fu X, Zhang R, Hazen SL, Levy AP. Haptoglobin genotype determines myocardial infarct size in diabetic mice. Journal of the American College of Cardiology. 49: 82-7. PMID 17207726 DOI: 10.1016/j.jacc.2006.08.044  1
2006 Lockwood SF, Penn MS, Hazen SL, Bikádi Z, Zsila F. The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sciences. 79: 162-74. PMID 16466747 DOI: 10.1016/j.lfs.2005.12.052  1
2005 Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 112: 2812-20. PMID 16267254 DOI: 10.1161/CIRCULATIONAHA.105.542340  1
2003 Brennan ML, Penn MS, Van Lente F, Nambi V, Shishehbor MH, Aviles RJ, Goormastic M, Pepoy ML, McErlean ES, Topol EJ, Nissen SE, Hazen SL. Prognostic value of myeloperoxidase in patients with chest pain. The New England Journal of Medicine. 349: 1595-604. PMID 14573731 DOI: 10.1056/NEJMoa035003  1
2003 Brennan ML, Hazen SL. Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment. Current Opinion in Lipidology. 14: 353-9. PMID 12865732 DOI: 10.1097/01.mol.0000083762.66245.51  1
2003 Askari AT, Brennan ML, Zhou X, Drinko J, Morehead A, Thomas JD, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. The Journal of Experimental Medicine. 197: 615-24. PMID 12615902 DOI: 10.1084/jem.20021426  1
2002 Brennan ML, Wu W, Fu X, Shen Z, Song W, Frost H, Vadseth C, Narine L, Lenkiewicz E, Borchers MT, Lusis AJ, Lee JJ, Lee NA, Abu-Soud HM, Ischiropoulos H, ... Hazen SL, et al. A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. The Journal of Biological Chemistry. 277: 17415-27. PMID 11877405 DOI: 10.1074/jbc.M112400200  1
2001 Denzler KL, Borchers MT, Crosby JR, Cieslewicz G, Hines EM, Justice JP, Cormier SA, Lindenberger KA, Song W, Wu W, Hazen SL, Gleich GJ, Lee JJ, Lee NA. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. Journal of Immunology (Baltimore, Md. : 1950). 167: 1672-82. PMID 11466391  1
2001 Shen Z, Mitra SN, Wu W, Chen Y, Yang Y, Qin J, Hazen SL. Eosinophil peroxidase catalyzes bromination of free nucleosides and double-stranded DNA. Biochemistry. 40: 2041-51. PMID 11329271  1
2000 Shen Z, Wu W, Hazen SL. Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical. Biochemistry. 39: 5474-82. PMID 10820020  1
2000 Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, Kavuru MS, Erzurum SC, Hazen SL. Eosinophils generate brominating oxidants in allergen-induced asthma. The Journal of Clinical Investigation. 105: 1455-63. PMID 10811853 DOI: 10.1172/JCI9702  1
1999 Schmitt D, Shen Z, Zhang R, Colles SM, Wu W, Salomon RG, Chen Y, Chisolm GM, Hazen SL. Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum. Biochemistry. 38: 16904-15. PMID 10606525 DOI: 10.1021/bi991623w  1
1999 Hazen SL, Zhang R, Shen Z, Wu W, Podrez EA, MacPherson JC, Schmitt D, Mitra SN, Mukhopadhyay C, Chen Y, Cohen PA, Hoff HF, Abu-Soud HM. Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo. Circulation Research. 85: 950-8. PMID 10559142  1
1999 Wu W, Chen Y, Hazen SL. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders. The Journal of Biological Chemistry. 274: 25933-44. PMID 10464338  1
1999 Wu W, Chen Y, d'Avignon A, Hazen SL. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry. 38: 3538-48. PMID 10090740 DOI: 10.1021/bi982401l  1
1994 Hazen SL, Wolf MJ, Ford DA, Gross RW. The rapid and reversible association of phosphofructokinase with myocardial membranes during myocardial ischemia Febs Letters. 339: 213-216. PMID 8112458 DOI: 10.1016/0014-5793(94)80418-4  1
1993 Hazen SL, Hall CR, Ford DA, Gross RW. Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates. The Journal of Clinical Investigation. 91: 2513-22. PMID 8514863 DOI: 10.1172/JCI116487  1
1993 Hazen SL, Gross RW. The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis. The Journal of Biological Chemistry. 268: 9892-900. PMID 8486669  1
1993 Zupan LA, Weiss RH, Hazen SL, Parnas BL, Aston KW, Lennon PJ, Getman DP, Gross RW. Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2. Journal of Medicinal Chemistry. 36: 95-100. PMID 8421294  1
1992 Hazen SL, Gross RW. Identification and characterization of human myocardial phospholipase A2 from transplant recipients suffering from end-stage ischemic heart disease. Circulation Research. 70: 486-95. PMID 1537086  1
1992 Han XL, Zupan LA, Hazen SL, Gross RW. Semisynthesis and purification of homogeneous plasmenylcholine molecular species. Analytical Biochemistry. 200: 119-24. PMID 1317681  1
1991 Ford DA, Hazen SL, Saffitz JE, Gross RW. The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia Journal of Clinical Investigation. 88: 331-335. PMID 2056126  1
1991 Hazen SL, Loeb LA, Gross RW. Purification and characterization of cytosolic phospholipase A2 activities from canine myocardium and sheep platelets. Methods in Enzymology. 197: 400-11. PMID 2051936  1
1991 Hazen SL, Zupan LA, Weiss RH, Getman DP, Gross RW. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2. The Journal of Biological Chemistry. 266: 7227-32. PMID 2016324  1
1991 Hazen SL, Ford DA, Gross RW. Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate Journal of Biological Chemistry. 266: 5629-5633. PMID 2005103  1
1991 Hazen SL, Gross RW. ATP-dependent regulation of rabbit myocardial cytosolic calcium-independent phospholipase A2. The Journal of Biological Chemistry. 266: 14526-34. PMID 1860859  1
1991 Hazen SL, Gross RW. Human myocardial cytosolic Ca(2+)-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition. The Biochemical Journal. 280: 581-7. PMID 1764021  1
1990 Hazen SL, Stuppy RJ, Gross RW. Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids. The Journal of Biological Chemistry. 265: 10622-30. PMID 2355013  1
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