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John Hampton Griffin - Publications

Affiliations: 
Numerate, Inc 
Area:
organic and biological chemistry
Website:
http://www.numerate.com/company/leadership/john_griffin.php
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365 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Deguchi H, Morla S, Griffin JH. Novel Blood Coagulation Molecules: Skeletal Muscle Myosin and Cardiac Myosin. Journal of Thrombosis and Haemostasis : Jth. PMID 32920971 DOI: 10.1111/Jth.15097  0.366
2020 von Drygalski A, Bhat V, Gale AJ, Averell PM, Cramer TJ, Elias DJ, Griffin JH, Mosnier LO. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms. Blood Advances. 4: 3716-3727. PMID 32777068 DOI: 10.1182/Bloodadvances.2020001699  0.417
2020 Mukherjee P, Lyden P, Fernández JA, Davis TP, Pryor KE, Zlokovic BV, Griffin JH. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase. Stroke. 51: 2236-2239. PMID 32568648 DOI: 10.1161/Strokeaha.120.028793  0.382
2020 Kant R, Halder SK, Fernández JA, Griffin JH, Milner R. Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation. Frontiers in Neuroscience. 14: 333. PMID 32351356 DOI: 10.3389/Fnins.2020.00333  0.364
2020 Calzavarini S, Prince Eladnani R, Saller F, Bologna LL, Burnier L, Brisset AC, Quarroz C, Reina Caro MD, Ermolayev V, Matsumura Y, Fernández JA, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus. Blood. PMID 32276277 DOI: 10.1182/Blood.2019003630  0.389
2020 Kondreddy V, Pendurthi UR, Xu X, Griffin JH, Rao LVM. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signal in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 Site. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314244. PMID 32212848 DOI: 10.1161/Atvbaha.120.314244  0.365
2020 Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120313990. PMID 32102568 DOI: 10.1161/Atvbaha.120.313990  0.347
2020 Yamashita A, Zhang Y, Sanner MF, Griffin JH, Mosnier LO. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities. Journal of Thrombosis and Haemostasis : Jth. PMID 32017367 DOI: 10.1111/Jth.14756  0.451
2019 Heeb MJ, Fernández JA, Yamashita A, McDowell OR, Guo Z, Mosnier LO, Deguchi H, Griffin JH. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin. Haematologica. PMID 31857364 DOI: 10.3324/Haematol.2019.242982  0.359
2019 Deguchi H, Guo Z, Hayat M, Pflimlin E, Lear S, Shen W, Griffin JH. Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation. The Journal of Biological Chemistry. PMID 31481465 DOI: 10.1074/Jbc.Ac119.010236  0.342
2019 Müller-Calleja N, Hollerbach A, Ritter S, Pedrosa DG, Strand D, Graf C, Reinhardt C, Strand S, Poncelet P, Griffin JH, Lackner KJ, Ruf W. Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis. Blood. PMID 31434703 DOI: 10.1182/Blood.2019001530  0.374
2019 Sinha RK, Flynn R, Zaiken M, Paz K, Gavin AL, Nemazee D, Fernández JA, Xu X, Griffin JH, Blazar BR. Activated Protein C Ameliorates Chronic Graft-Versus-Host Disease by PAR1-dependent Biased Cell Signaling on T-cells. Blood. PMID 31243040 DOI: 10.1182/Blood.2019001259  0.37
2019 Rajput PS, Lamb JA, Fernández JÁ, Bai J, Pereira BR, Lei IF, Leung J, Griffin JH, Lyden PD. Neuroprotection and Vasculoprotection using Genetically Targeted Protease-Ligands. Brain Research. PMID 30880117 DOI: 10.1016/J.Brainres.2019.03.010  0.316
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. The Journal of Experimental Medicine. PMID 30647119 DOI: 10.1084/Jem.20181035  0.352
2019 Zilberman-Rudenko J, Deguchi H, Hayat M, Shukla M, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Griffin JH. Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo Blood. 134: 3632-3632. DOI: 10.1182/Blood-2019-129312  0.378
2019 Deguchi H, Guo Z, Hayat M, Pflimlin E, Shen W, Griffin JH. Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation Blood. 134: 3622-3622. DOI: 10.1182/Blood-2019-129161  0.352
2019 Kondreddy VKR, Pendurthi UR, Xu X, Griffin JH, Rao LVM. Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site Blood. 134: 481-481. DOI: 10.1182/Blood-2019-124976  0.363
2019 Wang Y, Huuskonen MT, Montagne A, Zhao Z, Griffin JH, Zlokovic BV. Abstract WP139: MRI Evaluation and Functional Assessment of Brain Injury Improvement After 3K3A-Activated Protein C Treatment for Murine White Matter Stroke Stroke. 50. DOI: 10.1161/Str.50.Suppl_1.Wp139  0.318
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Vassar RJ, Griffin JH, Zlokovic BV. P2-057: 3K3A-Activated Protein C Blocks Amyloidogenic Bace1 Pathway And Improves Functional Outcome In Mice Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2464  0.348
2018 Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, ... ... Griffin JH, et al. Final Results of the RHAPSODY trial: A multi-center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke. Annals of Neurology. PMID 30450637 DOI: 10.1002/Ana.25383  0.361
2018 Mukherjee P, Leman LJ, Griffin JH, Ghadiri MR. Design of a DNA-programmed plasminogen activator. Journal of the American Chemical Society. PMID 30347143 DOI: 10.1021/Jacs.8B10166  0.324
2018 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1 and neuroprotection. Blood. PMID 29866816 DOI: 10.1182/Blood-2018-02-769026  0.407
2018 Healy LD, Rigg RA, Griffin JH, McCarty OJT. Regulation of immune cell signaling by activated protein C. Journal of Leukocyte Biology. PMID 29601101 DOI: 10.1002/Jlb.3Mir0817-338R  0.371
2018 Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. The Journal of Antimicrobial Chemotherapy. PMID 29514266 DOI: 10.1093/Jac/Dky033  0.327
2018 Martos L, Ramón LA, Oto J, Fernández-Pardo Á, Bonanad S, Cid AR, Gruber A, Griffin JH, España F, Navarro S, Medina P. α2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:α2M Levels Are Associated with Venous Thromboembolism. Thrombosis and Haemostasis. PMID 29448296 DOI: 10.1055/S-0038-1629902  0.4
2018 Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernandez JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke. Blood. PMID 29343482 DOI: 10.1182/Blood-2017-10-810895  0.334
2018 Prince R, Bologna L, Manetti M, Melchiorre D, Rosa I, Dewarrat N, Suardi S, Amini P, Fernández JA, Burnier L, Quarroz C, Reina Caro MD, Matsumura Y, Kremer Hovinga JA, Griffin JH, et al. Targeting anticoagulant protein S to improve hemostasis in hemophilia. Blood. PMID 29317453 DOI: 10.1182/Blood-2017-09-800326  0.398
2018 Heeb MJ, McDowell O, Yamashita A, Fernandez JA, Mosnier LO, Deguchi H, Griffin JH. Abstract 520: Skeletal Muscle Myosin Supports the Anticoagulant Functions of Activated Protein C and Protein S but not Protein C Activation by Thrombin:Thrombomodulin Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.520  0.398
2018 Zilberman-Rudenko J, Deguchi H, Orje J, Wyseure T, Mosnier LO, McCarty OJ, Ruggeri ZM, Griffin JH. Abstract 148: Cardiac Myosin Promotes Thrombin Generation and Attenuates Tissue Plasminogen Activator-induced Plasma Clot Lysis Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.148  0.33
2017 Fernández JA, Xu X, Sinha RK, Mosnier LO, Sanner MF, Griffin JH. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S. Blood Advances. 1: 1423-1426. PMID 29296783 DOI: 10.1182/Bloodadvances.2017007005  0.373
2017 Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. PMID 28923278 DOI: 10.1016/J.Neuropharm.2017.09.021  0.32
2017 Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, et al. Cytoprotective activated protein C averts Nlrp3 inflammasome induced ischemia reperfusion injury via mTORC1 inhibition. Blood. PMID 28882883 DOI: 10.1182/Blood-2017-05-782102  0.373
2017 Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJ. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. The Journal of Biological Chemistry. PMID 28408624 DOI: 10.1074/Jbc.M116.768309  0.42
2016 Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27758767 DOI: 10.1161/Atvbaha.116.308038  0.376
2016 Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nature Medicine. PMID 27548576 DOI: 10.1038/Nm.4154  0.369
2016 Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJ, Cohen MJ, Griffin JH. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood. PMID 27421960 DOI: 10.1182/Blood-2016-03-707679  0.376
2016 Burnier L, Boroujerdi A, Fernández JA, Welser-Alves JV, Griffin JH, Milner R. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C. Experimental Neurology. PMID 27412766 DOI: 10.1016/J.Expneurol.2016.07.004  0.364
2016 Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thrombosis Research. 141: S62-S64. PMID 27207428 DOI: 10.1016/S0049-3848(16)30368-1  0.409
2016 Alsultan A, Gale AJ, Kurban K, Khalifah M, Albadr FB, Griffin JH. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis. Thrombosis Research. 143: 17-21. PMID 27172833 DOI: 10.1016/J.Thromres.2016.04.011  0.317
2016 Sinha RK, Yang XV, Fernández JA, Xu X, Mosnier LO, Griffin JH. Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26800564 DOI: 10.1161/Atvbaha.115.306795  0.348
2016 Sinha RK, Flynn RP, Fernandez JA, Xu X, Martin G, Kupriyanov S, Griffin JH, Blazar BR. Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells Blood. 128: 808-808. DOI: 10.1182/Blood.V128.22.808.808  0.355
2016 Sinha RK, Wang Y, Zhao Z, Fernandez JA, Gupta N, Xu X, Martin G, Kupriyanov S, Mosnier LO, Zlokovic B, Griffin JH. Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke Blood. 128: 13-13. DOI: 10.1182/Blood.V128.22.13.13  0.339
2015 Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. Thrombosis and Haemostasis. 115. PMID 26466980 DOI: 10.1160/Th15-07-0525  0.348
2015 Amar AP, Griffin JH, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Frontiers in Cellular Neuroscience. 9: 344. PMID 26388732 DOI: 10.3389/Fncel.2015.00344  0.315
2015 Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood. PMID 26341257 DOI: 10.1182/Blood-2015-05-644401  0.407
2015 Yegneswaran S, Banerjee Y, Fernández JA, Deguchi H, Griffin JH. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex. Plos One. 10: e0135025. PMID 26263376 DOI: 10.1371/Journal.Pone.0135025  0.384
2015 Banno F, Kita T, Fernández JA, Yanamoto H, Tashima Y, Kokame K, Griffin JH, Miyata T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 126: 2247-53. PMID 26251307 DOI: 10.1182/Blood-2015-06-653162  0.351
2015 Deguchi H, Wolfbauer G, Cheung MC, Banerjee Y, Elias DJ, Fernández JA, Albers JJ, Griffin JH. Inhibition of thrombin generation in human plasma by phospholipid transfer protein. Thrombosis Journal. 13: 24. PMID 26185485 DOI: 10.1186/S12959-015-0054-0  0.406
2015 Deguchi H, Banerjee Y, Trauger S, Siuzdak G, Kalisiak E, Fernández JA, Hoang L, Tran M, Yegneswaran S, Elias DJ, Griffin JH. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data. Blood. 126: 1595-600. PMID 26175037 DOI: 10.1182/Blood-2015-03-636761  0.368
2015 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 125: 2898-907. PMID 25824691 DOI: 10.1182/Blood-2015-02-355974  0.419
2015 Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 125: 2845-54. PMID 25733582 DOI: 10.1182/Blood-2014-11-610717  0.341
2015 Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin JH. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 570-2. PMID 25550205 DOI: 10.1161/Atvbaha.114.304938  0.381
2015 Yegneswaran S, Banerjee Y, Fernández JA, Deguchi H, Griffin JH. Inhibitory activity of lyso-SF. Plos One. DOI: 10.1371/Journal.Pone.0135025.G002  0.328
2015 Deguchi H, Sinha RK, Elias DJ, Griffin JH. Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors Blood. 126: 763-763. DOI: 10.1182/Blood.V126.23.763.763  0.339
2015 Griffin JH, Fernandez JA, Sinha RK, Elias DJ, Deguchi H. Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients Blood. 126: 3486-3486. DOI: 10.1182/Blood.V126.23.3486.3486  0.407
2015 Prince R, Angelillo-Scherrer A, Griffin JH, Calzavarini S, Matsumura Y, Saller F. Role of Protein S and Gas6 in the Development of Purpura Fulminans Blood. 126: 1042-1042. DOI: 10.1182/Blood.V126.23.1042.1042  0.301
2014 Mosnier LO, Zlokovic BV, Griffin JH. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thrombosis and Haemostasis. 112: 883-92. PMID 25230930 DOI: 10.1160/Th14-05-0448  0.336
2014 von Drygalski A, Bhat V, Gale AJ, Burnier L, Cramer TJ, Griffin JH, Mosnier LO. An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C. Plos One. 9: e104304. PMID 25127130 DOI: 10.1371/Journal.Pone.0104304  0.422
2014 von Drygalski A, Cramer TJ, Bhat V, Griffin JH, Gale AJ, Mosnier LO. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant. Journal of Thrombosis and Haemostasis : Jth. 12: 363-72. PMID 24818532 DOI: 10.1111/Jth.12489  0.35
2014 Deguchi H, Elias DJ, Trauger S, Zhang HM, Kalisiak E, Siuzdak G, Griffin JH. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids. British Journal of Haematology. 165: 409-12. PMID 24450944 DOI: 10.1111/Bjh.12720  0.345
2014 Deguchi H, Elias DJ, Griffin JH. Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution. Journal of Thrombosis and Haemostasis : Jth. 12: 90-2. PMID 24406066 DOI: 10.1111/Jth.12446  0.369
2014 Sinha RK, Burnier L, Gupta N, Xu X, Kupriyanov S, Martin G, Mosnier LO, Griffin JH. Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC) Blood. 124: 99-99. DOI: 10.1182/Blood.V124.21.99.99  0.338
2014 Bhat V, Gale AJ, Griffin JH, Mosnier LO, von Drygalski A. Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered superfactor Va Blood. 124: 695-695. DOI: 10.1182/Blood.V124.21.695.695  0.357
2014 Bhat V, von Drygalski A, Gale AJ, Griffin JH, Mosnier LO. Synergistic Effect in Bleed Reduction By superfva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors Blood. 124: 692-692. DOI: 10.1182/Blood.V124.21.692.692  0.364
2014 Deguchi H, Banerjee Y, Siuzdak G, Trauger S, Kalisiak E, Fernandez JA, Hoang L, Tran M, Yegneswaran S, Elias DJ, Griffin JH. Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics Blood. 124: 2797-2797. DOI: 10.1182/Blood.V124.21.2797.2797  0.373
2014 Martos L, Medina P, Deguchi H, Bonet E, Ramón L, Ferrando F, Mira Y, Vayá A, Bonanad S, Aznar JA, Griffin J, España F, Navarro Rosales S. C0136: A Modification of Calibrated Automated Thrombin Generation Assay to Explore New Cofactors of Activated Protein C in Plasma Thrombosis Research. 133: S71. DOI: 10.1016/S0049-3848(14)50233-2  0.416
2014 Fernandez J, Sinja R, Mosnier L, Xu X, Cramer T, Griffin J. C0047: Cytoprotective Selective Human 3K3A-Activated Protein C Variant Detoxifies Histone H1 and Stabilizes Endothelium from Pro-Inflammatory Cytokines Thrombosis Research. 133: S9-S10. DOI: 10.1016/S0049-3848(14)50058-8  0.344
2013 Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Current Pharmaceutical Design. 19: 7479-85. PMID 24372304 DOI: 10.2174/1381612819666131230131454  0.311
2013 Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. Journal of Thrombosis and Haemostasis : Jth. 11: 2059-62. PMID 24034518 DOI: 10.1111/Jth.12400  0.405
2013 Heeb MJ, Mesters RM, Fernández JA, Hackeng TM, Nakasone RK, Griffin JH. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation. Thrombosis and Haemostasis. 110: 275-82. PMID 23892573 DOI: 10.1160/Th12-12-0953  0.398
2013 Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6181-90. PMID 23554499 DOI: 10.1523/Jneurosci.4491-12.2013  0.361
2013 Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells, Molecules & Diseases. 51: 104-8. PMID 23541526 DOI: 10.1016/J.Bcmd.2013.02.009  0.349
2013 Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Research. 1507: 97-104. PMID 23438513 DOI: 10.1016/J.Brainres.2013.02.023  0.329
2013 von Drygalski A, Furlan-Freguia C, Ruf W, Griffin JH, Mosnier LO. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 769-76. PMID 23393392 DOI: 10.1161/Atvbaha.112.301082  0.33
2013 Burnier L, Fernández JA, Griffin JH. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. Blood Cells, Molecules & Diseases. 50: 252-8. PMID 23385154 DOI: 10.1016/J.Bcmd.2013.01.002  0.415
2013 Alsultan A, Gale AJ, Kurban K, Khalifah M, Albadr FB, Griffin JH. Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage Blood. 122: 3587-3587. DOI: 10.1182/Blood.V122.21.3587.3587  0.423
2013 Von Drygalski A, Gale AJ, Burnier L, Cramer TJ, Griffin JH, Mosnier LO. An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C Blood. 122: 203-203. DOI: 10.1182/Blood.V122.21.203.203  0.375
2012 Mosnier LO, Sinha RK, Burnier L, Bouwens EA, Griffin JH. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood. 120: 5237-46. PMID 23149848 DOI: 10.1182/Blood-2012-08-452169  0.386
2012 Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. Journal of the American Chemical Society. 134: 19318-21. PMID 23066897 DOI: 10.1021/Ja306993T  0.306
2012 Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke; a Journal of Cerebral Circulation. 43: 2444-9. PMID 22811462 DOI: 10.1161/Strokeaha.112.658997  0.305
2012 Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernández JÁ, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, ... ... Griffin JH, et al. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nature Medicine. 18: 1123-9. PMID 22729286 DOI: 10.1038/Nm.2813  0.328
2012 Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Current Pharmaceutical Design. 18: 4215-22. PMID 22632606 DOI: 10.2174/138161212802430413  0.364
2012 Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. International Journal of Hematology. 95: 333-45. PMID 22477541 DOI: 10.1007/S12185-012-1059-0  0.456
2012 Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, et al. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood. 119: 874-83. PMID 22117049 DOI: 10.1182/Blood-2011-07-365973  0.372
2012 Hansen JB, Fernández JA, Borch KH, Griffin JH, Brox JH, Braekkan SK. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism. Thrombosis Research. 129: 502-7. PMID 21777953 DOI: 10.1016/J.Thromres.2011.06.026  0.419
2012 Weiler H, Griffin JH. Activated Protein C, Sepsis, and the Innate Immune Response to Infection Blood. 120. DOI: 10.1182/Blood.V120.21.Sci-43.Sci-43  0.322
2012 Burnier L, Sinha RK, Bouwens EA, Griffin JH, Mosnier LO. Protection Against Vascular Leakage in Vivo by a Peptide Mimetic of the Novel Tethered Ligand Generated by Non-Canonical Cleavage of Protease Activated Receptor 1 by Activated Protein C Blood. 120: 497-497. DOI: 10.1182/Blood.V120.21.497.497  0.359
2012 Burnier L, Fernandez JA, Griffin JH. In Vitro and in Vivo Neutralization of Murine Activated Protein C Blood. 120: 3364-3364. DOI: 10.1182/Blood.V120.21.3364.3364  0.477
2012 Kerschen EJ, Liang HH, Fernandez JA, Toso R, Ruf W, Camire RM, Griffin JH, Weiler H. Factor V Inhibits PAR2-Mediated Lethal Inflammation Blood. 120: 3360-3360. DOI: 10.1182/Blood.V120.21.3360.3360  0.411
2012 Von Drygalski A, Cramer TJ, Griffin JH, Gale AJ, Mosnier LO. Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice Blood. 120: 17-17. DOI: 10.1182/Blood.V120.21.17.17  0.348
2012 Sinha RK, Yang X, Mosnier LO, Griffin JH. Activated Protein C Cytoprotective Signaling in Endothelial Cells Involves apoER2 and Disabled-1 Blood. 120: 1102-1102. DOI: 10.1182/Blood.V120.21.1102.1102  0.323
2011 Raife TJ, Dwyre DM, Stevens JW, Erger RA, Leo L, Wilson KM, Fernández JA, Wilder J, Kim HS, Griffin JH, Maeda N, Lentz SR. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2509-17. PMID 21885846 DOI: 10.1161/Atvbaha.111.236828  0.311
2011 Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends in Neurosciences. 34: 198-209. PMID 21353711 DOI: 10.1016/J.Tins.2011.01.005  0.34
2011 Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Molecular Neurodegeneration. 6: 13. PMID 21291561 DOI: 10.1186/1750-1326-6-13  0.303
2011 Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernández JA, Griffin JH, Pittet JF. Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. American Journal of Respiratory Cell and Molecular Biology. 45: 632-41. PMID 21257925 DOI: 10.1165/Rcmb.2010-0397Oc  0.374
2011 Griffin JH, Mosnier LO. Activated Protein C Cellular Pathways Regulating Thrombosis Blood. 118: SCI-44-SCI-44. DOI: 10.1182/Blood.V118.21.Sci-44.Sci-44  0.391
2011 Mosnier LO, Griffin JH. Non-Canonical Cleavage of Protease Activated Receptor 1 (PAR1) by Activated Protein C Provides Novel Insights Into the Repertoire of Cytoprotective and Proinflammatory PAR1 Signaling Blood. 118: 534-534. DOI: 10.1182/Blood.V118.21.534.534  0.365
2011 Calzavarini S, Saller F, Fernandez JA, Kadi L, Brisset AC, Burnier L, Azevedo M, Ternon B, Griffin JH, Angelillo-Scherrer A. Insight in Protein S Deficiency From Mouse Models Blood. 118: 529-529. DOI: 10.1182/Blood.V118.21.529.529  0.336
2011 Fernandez JA, Deguchi H, Pecheniuk NM, Yegneswaran S, Banka CL, Griffin JH. Plasma High Density Lipoprotein and Anticoagulant Response to Activated Protein C (APC) and Protein S Blood. 118: 2249-2249. DOI: 10.1182/Blood.V118.21.2249.2249  0.361
2011 Deguchi H, Trauger S, Kalisiak E, Zhang H, Siuzdak G, Griffin JH, Elias DJ. Warfarin Untargeted Metabolomics Study Identifies Novel Procoagulant Ethanolamide Lipids Blood. 118: 1200-1200. DOI: 10.1182/Blood.V118.21.1200.1200  0.337
2010 Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. The Journal of Clinical Investigation. 120: 3167-78. PMID 20714108 DOI: 10.1172/Jci42629  0.323
2010 Cramer TJ, Griffin JH, Gale AJ. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va. Pathophysiology of Haemostasis and Thrombosis. 37: 17-23. PMID 20501981 DOI: 10.1159/000315141  0.458
2010 Von Drygalski A, Furlan-Freguia C, Mosnier LO, Ruf W, Griffin JH. Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation Blood. 116: 653-653. DOI: 10.1182/Blood.V116.21.653.653  0.311
2010 Deguchi H, Elias DJ, Navarro S, Espana F, Griffin JH. Plasma Serum Amyloid A Levels Are Increased In Venous Thrombosis Patients and Are Correlated with Blood Coagulability Blood. 116: 155-155. DOI: 10.1182/Blood.V116.21.155.155  0.393
2010 Yegneswaran S, Banerjee Y, Fernandez JA, Deguchi H, Griffin JH. Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation. Blood. 116: 1130-1130. DOI: 10.1182/Blood.V116.21.1130.1130  0.343
2009 Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of Clinical Investigation. 119: 3437-49. PMID 19841542 DOI: 10.1172/Jci38476  0.351
2009 Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 94: 1721-31. PMID 19815836 DOI: 10.3324/Haematol.2009.009233  0.365
2009 Saller F, Brisset AC, Tchaikovski SN, Azevedo M, Chrast R, Fernández JA, Schapira M, Hackeng TM, Griffin JH, Angelillo-Scherrer A. Generation and phenotypic analysis of protein S-deficient mice. Blood. 114: 2307-14. PMID 19567881 DOI: 10.1182/Blood-2009-03-209031  0.346
2009 Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thrombosis and Haemostasis. 101: 724-33. PMID 19350118 DOI: 10.1160/Th08-10-0632  0.357
2009 Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. The European Journal of Neuroscience. 29: 1119-30. PMID 19302148 DOI: 10.1111/J.1460-9568.2009.06664.X  0.403
2009 Heeb MJ, Prashun D, Griffin JH, Bouma BN. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2244-53. PMID 19244162 DOI: 10.1096/Fj.08-123174  0.413
2009 Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernández JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood. 113: 5970-8. PMID 19244160 DOI: 10.1182/Blood-2008-10-183327  0.434
2009 Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. Journal of Neurochemistry. 109: 116-24. PMID 19166505 DOI: 10.1111/J.1471-4159.2009.05921.X  0.354
2009 Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 113: 2859-66. PMID 19141861 DOI: 10.1182/Blood-2008-12-192385  0.32
2009 Yegneswaran S, Nguyen PM, Gale AJ, Griffin JH. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thrombosis and Haemostasis. 101: 55-61. PMID 19132189 DOI: 10.1160/Th08-07-0491  0.439
2009 Yang XV, Banerjee Y, Fernández JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 274-9. PMID 19116273 DOI: 10.1073/Pnas.0807594106  0.39
2008 Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12788-97. PMID 19036971 DOI: 10.1523/Jneurosci.3485-08.2008  0.368
2008 Yegneswaran S, Hackeng TM, Dawson PE, Griffin JH. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. The Journal of Biological Chemistry. 283: 33046-52. PMID 18784085 DOI: 10.1074/Jbc.M806527200  0.354
2008 Pecheniuk NM, Elias DJ, Deguchi H, Averell PM, Griffin JH. Elevated plasma fibronectin levels associated with venous thromboembolism. Thrombosis and Haemostasis. 100: 224-8. PMID 18690341 DOI: 10.1160/Th08-02-0078  0.301
2008 White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernández JA, Griffin JH, Gruber A, McCarty OJ. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. Journal of Thrombosis and Haemostasis : Jth. 6: 995-1002. PMID 18489431 DOI: 10.1111/J.1538-7836.2008.02979.X  0.42
2008 Heeb MJ, Gandrille S, Fernandez JA, Griffin JH, Fedullo PF. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. Journal of Thrombosis and Haemostasis : Jth. 6: 1235-7. PMID 18433462 DOI: 10.1111/J.1538-7836.2008.02994.X  0.392
2008 Yang XV, Banerjee Y, Fernandez JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, deGroot PG, White TC, McCarty OJT, Griffin JH. Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2) Blood. 112: 695-695. DOI: 10.1182/Blood.V112.11.695.695  0.378
2008 Cramer TJ, Griffin JH, Gale AJ. Factor V as Anticoagulant Cofactor for Activated Protein C in Factor Va Inactivation Blood. 112: 3075-3075. DOI: 10.1182/Blood.V112.11.3075.3075  0.464
2007 Deguchi H, Fernández JA, Griffin JH. Plasma cholesteryl ester transfer protein and blood coagulability. Thrombosis and Haemostasis. 98: 1160-4. PMID 18064308 DOI: 10.1160/Th07-07-0451  0.38
2007 Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. The Journal of Experimental Medicine. 204: 2439-48. PMID 17893198 DOI: 10.1084/Jem.20070404  0.413
2007 Mosnier LO, Yang XV, Griffin JH. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. The Journal of Biological Chemistry. 282: 33022-33. PMID 17872949 DOI: 10.1074/Jbc.M705824200  0.44
2007 Yegneswaran S, Kojima Y, Nguyen PM, Gale AJ, Heeb MJ, Griffin JH. Factor Va residues 311-325 represent an activated protein C binding region. The Journal of Biological Chemistry. 282: 28353-61. PMID 17646160 DOI: 10.1074/Jbc.M704316200  0.356
2007 Griffin JH, Fernández JA, Gale AJ, Mosnier LO. Activated protein C. Journal of Thrombosis and Haemostasis : Jth. 5: 73-80. PMID 17635713 DOI: 10.1111/J.1538-7836.2007.02491.X  0.443
2007 Gale AJ, Yegneswaran S, Xu X, Pellequer JL, Griffin JH. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. The Journal of Biological Chemistry. 282: 21848-55. PMID 17553804 DOI: 10.1074/Jbc.M702192200  0.362
2007 Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood. 109: 3733-40. PMID 17227834 DOI: 10.1182/Blood-2006-07-035147  0.432
2007 Raivio P, Fernández JA, Kuitunen A, Griffin JH, Lassila R, Petäjä J. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery. The Journal of Thoracic and Cardiovascular Surgery. 133: 44-51. PMID 17198779 DOI: 10.1016/J.Jtcvs.2006.10.003  0.388
2007 Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 109: 3161-72. PMID 17110453 DOI: 10.1182/Blood-2006-09-003004  0.444
2007 Radtke KP, Griffin JH, Riceberg J, Gale AJ. Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays. Journal of Thrombosis and Haemostasis : Jth. 5: 102-8. PMID 17059431 DOI: 10.1111/J.1538-7836.2006.02283.X  0.345
2007 Mosnier LO, Fernandez JA, Zampolli A, Yang XV, Ruggeri ZM, Griffin JH. In Vivo Anti-Thrombotic Potency of Engineered Activated Protein C Variants. Blood. 110: 2704-2704. DOI: 10.1182/Blood.V110.11.2704.2704  0.455
2007 Mosnier LO, Yang XV, Griffin JH. Preservation of Beneficial TAFI Functions by an Activated Protein C Variant with Normal Cytoprotective Functions but Minimal Anticoagulant Activity. Blood. 110: 268-268. DOI: 10.1182/Blood.V110.11.268.268  0.395
2006 Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine. 12: 1278-85. PMID 17072311 DOI: 10.1038/Nm1498  0.368
2006 Pecheniuk NM, Deguchi H, Elias DJ, Xu X, Griffin JH. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males. Journal of Thrombosis and Haemostasis : Jth. 4: 2080-2. PMID 16961620 DOI: 10.1111/J.1538-7836.2006.02099.X  0.306
2006 Fernández JA, Lentz SR, Dwyre DM, Griffin JH. A novel ELISA for mouse activated protein C in plasma. Journal of Immunological Methods. 314: 174-81. PMID 16828789 DOI: 10.1016/J.Jim.2006.05.004  0.41
2006 Mineo C, Deguchi H, Griffin JH, Shaul PW. Endothelial and antithrombotic actions of HDL. Circulation Research. 98: 1352-64. PMID 16763172 DOI: 10.1161/01.Res.0000225982.01988.93  0.323
2006 Fernández JA, Vento AE, Jormalainen M, Griffin JH, Pesonen E, Syrjälä M, Repo H, Jansson SE, Rämö OJ, Petäjä J. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 20: 113-21. PMID 16761191 DOI: 10.1007/S10557-006-7448-Y  0.351
2006 Mosnier LO, Griffin JH. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities. Frontiers in Bioscience : a Journal and Virtual Library. 11: 2381-99. PMID 16720321 DOI: 10.2741/1977  0.449
2006 Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin JH, Riewald M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. The Journal of Biological Chemistry. 281: 20077-84. PMID 16709569 DOI: 10.1074/Jbc.M600506200  0.412
2006 Gale AJ, Radtke KP, Cunningham MA, Chamberlain D, Pellequer JL, Griffin JH. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants. Journal of Thrombosis and Haemostasis : Jth. 4: 1315-22. PMID 16706977 DOI: 10.1111/J.1538-7836.2006.01951.X  0.333
2006 Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells, Molecules & Diseases. 36: 211-6. PMID 16464623 DOI: 10.1016/J.Bcmd.2005.12.023  0.413
2006 Ilmakunnas M, Pesonen EJ, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Repo H, Siitonen S, Petäjä J. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation. Critical Care Medicine. 34: 426-32. PMID 16424724 DOI: 10.1097/01.Ccm.0000198108.38349.28  0.362
2006 Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis. Critical Care (London, England). 10: R16. PMID 16420659 DOI: 10.1186/Cc3966  0.329
2006 Gruber A, Fernández JA, Bush L, Marzec U, Griffin JH, Hanson SR, DI Cera E. Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates. Journal of Thrombosis and Haemostasis : Jth. 4: 392-7. PMID 16420571 DOI: 10.1111/J.1538-7836.2006.01760.X  0.398
2006 Tanaka KA, Fernández JA, Marzec UM, Kelly AB, Mohri M, Griffin JH, Hanson SR, Gruber A. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates. British Journal of Haematology. 132: 197-203. PMID 16398653 DOI: 10.1111/J.1365-2141.2005.05855.X  0.428
2006 Yang XV, Griffin JH, Mosnier LO. Anti-Inflammatory and Anti-Apoptotic Activities of Activated Protein C Are Independent of Anticoagulant Activity. Blood. 108: 65-65. DOI: 10.1182/Blood.V108.11.65.65  0.405
2006 Eichinger S, Pecheniuk NM, Hron G, Deguchi H, Kyrle PA, Griffin JH. Risk of Recurrent Venous Thromboembolism Reduced by High Density Lipoproteins. Blood. 108: 271-271. DOI: 10.1182/Blood.V108.11.271.271  0.342
2006 Mosnier LO, Ochoa RL, Griffin JH. Platelet Factor 4 (PF4) Modulation of Endothelial Protein C Receptor and Thrombomodulin Enhancements of Protein C Activation and TAFI Activation by Thrombin. Blood. 108: 1791-1791. DOI: 10.1182/Blood.V108.11.1791.1791  0.402
2006 Kerschen EJ, Cooley BC, Castellino FJ, Coughlin SR, Fernandez JA, Griffin JH, Weiler H. Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis. Blood. 108: 1-1. DOI: 10.1182/Blood.V108.11.1.1  0.38
2006 Fernandez J, Lentz S, Dwyre D, Griffin J. ID: 068 A Novel ELISA for Mouse Activated Protein C in Plasma Based on Interspecies Inhibition by Human Protein C Inhibitor Journal of Thrombosis and Haemostasis. 4: 196-196. DOI: 10.1111/J.1538-7836.2006.00068.X  0.432
2005 Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Annals of Neurology. 58: 474-7. PMID 16130108 DOI: 10.1002/Ana.20602  0.363
2005 Turunen AJ, Fernández JA, Lindgren L, Salmela KT, Kyllönen LE, Mäkisalo H, Griffin JH, Siitonen SM, Petäjä J, Pesonen EJ. Activated protein C reduces graft neutrophil activation in clinical renal transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 5: 2204-12. PMID 16095499 DOI: 10.1111/J.1600-6143.2005.00994.X  0.313
2005 Deguchi H, Bouma BN, Middeldorp S, Lee YM, Griffin JH. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide. Journal of Thrombosis and Haemostasis : Jth. 3: 935-8. PMID 15869587 DOI: 10.1111/J.1538-7836.2005.01335.X  0.355
2005 Pecheniuk NM, Deguchi H, Griffin JH. Cholesterol enhances phospholipid-dependent activated protein C anticoagulant activity. Journal of Thrombosis and Haemostasis : Jth. 3: 340-5. PMID 15670041 DOI: 10.1111/J.1538-7836.2005.01112.X  0.364
2005 Mosnier LO, Griffin JH. Activated Protein C Light Chain Mutations Distinguish Exosite Residue Requirements for Anticoagulant Versus Cytoprotective Activities. Blood. 106: 29-29. DOI: 10.1182/Blood.V106.11.29.29  0.441
2005 Feistritzer C, Mosnier LO, Di Cera E, Griffin JH, Riewald M. Efficient Barrier Protective Signaling by Activated Protein C Is Mechanistically Linked to Protein C Activation on Endothelial Cells. Blood. 106: 28-28. DOI: 10.1182/Blood.V106.11.28.28  0.385
2005 Kerschen EJ, Cooley BC, Castellino FJ, Griffin JH, Weiler H. Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action. Blood. 106: 26-26. DOI: 10.1182/Blood.V106.11.26.26  0.398
2004 Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine. 10: 1379-83. PMID 15516929 DOI: 10.1038/Nm1122  0.344
2004 Contreras JL, Eckstein C, Smyth CA, Bilbao G, Vilatoba M, Ringland SE, Young C, Thompson JA, Fernández JA, Griffin JH, Eckhoff DE. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes. 53: 2804-14. PMID 15504960 DOI: 10.2337/Diabetes.53.11.2804  0.339
2004 Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livneh A, Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Annals of the Rheumatic Diseases. 63: 1445-9. PMID 15479893 DOI: 10.1136/Ard.2003.014241  0.356
2004 Yegneswaran S, Mesters RM, Fernández JA, Griffin JH. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex. The Journal of Biological Chemistry. 279: 49019-25. PMID 15331602 DOI: 10.1074/Jbc.M406645200  0.311
2004 Mosnier LO, Gale AJ, Yegneswaran S, Griffin JH. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood. 104: 1740-4. PMID 15178575 DOI: 10.1182/blood-2004-01-0110  0.34
2004 Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Critical Care Medicine. 32: S247-53. PMID 15118526 DOI: 10.1097/01.Ccm.0000126127.87484.2B  0.365
2004 Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 41: 563-72. PMID 14980205 DOI: 10.1016/S0896-6273(04)00019-4  0.359
2004 Gale AJ, Griffin JH. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va. Proteins. 54: 433-41. PMID 14747992 DOI: 10.1002/Prot.10627  0.429
2004 Deguchi H, Yegneswaran S, Griffin JH. Sphingolipids as bioactive regulators of thrombin generation. The Journal of Biological Chemistry. 279: 12036-42. PMID 14722105 DOI: 10.1074/Jbc.M302531200  0.371
2004 Gruber A, Fernandez JA, Marzec UM, Bush L, Griffin JH, Hanson SR, Di Cera E. Sustained Pharmacological Activation of Protein C (PC) in Baboons. Blood. 104: 3499-3499. DOI: 10.1182/Blood.V104.11.3499.3499  0.348
2004 Raife TJ, Erger RA, Wilson KM, Fernandez JA, Alternburg J, Kim H, Griffin JH, Maeda N, Lentz SR. Targeted Replacement of the Murine Thrombomodulin Gene with Human Thrombomodulin Coding Sequence Results in Decreased Protein C Activation and Enhanced Thrombotic Response to Photochemical Injury. Blood. 104: 2980-2980. DOI: 10.1182/Blood.V104.11.2980.2980  0.329
2004 Radtke K, Chamberlain D, Griffin JH, Gale AJ. Whole Blood Thromboelastogram Assays Demonstrate Prolonged Factor VIIIa Potency for Recombinant Disulfide Bond-Stabilized Factor VIII Variants. Blood. 104: 2976-2976. DOI: 10.1182/Blood.V104.11.2976.2976  0.314
2004 Gale AJ, Griffin JH. Factor Xa Binding Sites on Factor Va in the Prothrombinase Complex. Blood. 104: 1713-1713. DOI: 10.1182/Blood.V104.11.1713.1713  0.365
2004 Ilmakunnas M, Pesonen EJ, Höckerstedt K, Mäkisalo H, Repo H, Fernandez JA, Griffin JH, Petäjä J. INTRAHEPATIC PROTEIN C ACTIVATION DURING REPERFUSION IN HUMAN LIVER TRANSPLANTATION REDUCES PHAGOCYTE ACTIVATION Transplantation. 78: 210. DOI: 10.1097/00007890-200407271-00549  0.351
2003 Yegneswaran S, Mesters RM, Griffin JH. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. The Journal of Biological Chemistry. 278: 33312-8. PMID 12805370 DOI: 10.1074/Jbc.M305906200  0.333
2003 Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells, Molecules & Diseases. 30: 271-6. PMID 12737945 DOI: 10.1016/S1079-9796(03)00034-2  0.403
2003 Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. The Biochemical Journal. 373: 65-70. PMID 12683950 DOI: 10.1042/Bj20030341  0.415
2003 Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 107: 1791-6. PMID 12665496 DOI: 10.1161/01.Cir.0000058460.34453.5A  0.339
2003 Slungaard A, Fernandez JA, Griffin JH, Key NS, Long JR, Piegors DJ, Lentz SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood. 102: 146-51. PMID 12609838 DOI: 10.1182/Blood-2002-11-3529  0.388
2003 Ilmakunnas M, Petäjä J, Höckerstedt K, Mäkisalo H, Fernandez JA, Griffin JH, Jansson SE, Repo H, Pesonen EJ. Activation of protein C during reperfusion in clinical liver transplantation. Transplantation. 75: 467-72. PMID 12605111 DOI: 10.1097/01.Tp.0000046529.83650.8A  0.353
2003 Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 101: 4797-801. PMID 12586611 DOI: 10.1182/Blood-2002-12-3680  0.334
2003 Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine. 9: 338-42. PMID 12563316 DOI: 10.1038/Nm826  0.394
2003 Yegneswaran S, Deguchi H, Griffin JH. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles. The Journal of Biological Chemistry. 278: 14614-21. PMID 12560338 DOI: 10.1074/Jbc.M206746200  0.351
2002 Heeb MJ, Griffin JH. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements. Blood Cells, Molecules & Diseases. 29: 190-9. PMID 12490286 DOI: 10.1006/Bcmd.2002.0558  0.439
2002 Heeb MJ, Paganini-Hill A, Griffin JH, Fisher M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender Blood Cells, Molecules & Diseases. 29: 139-144. PMID 12490280 DOI: 10.1006/Bcmd.2002.0549  0.332
2002 Fernández JA, Gruber A, Heeb MJ, Griffin JH. Protein C pathway impairment in nonsymptomatic cigarette smokers Blood Cells, Molecules & Diseases. 29: 73-82. PMID 12482406 DOI: 10.1006/Bcmd.2002.0542  0.365
2002 Simmelink MJA, De Groot PG, Derksen RHWM, Fernández JA, Griffin JH. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors Blood. 100: 4232-4233. PMID 12393585 DOI: 10.1182/Blood-2002-01-0329  0.433
2002 Lentz SR, Piegors DJ, Fernández JA, Erger RA, Arning E, René Malinow M, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD. Effect of hyperhomocysteinemia on protein C activation and activity Blood. 100: 2108-2112. PMID 12200374 DOI: 10.1182/Blood-2002-03-0727  0.375
2002 Kottke-Marchant K, Bahit MC, Granger CB, Zoldhelyi P, Ardissino D, Brooks L, Griffin JH, Potthoff RF, Van De Werf F, Califf RM, Topol EJ. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes: The GUSTO-IIb haemostasis substudy European Heart Journal. 23: 1202-1212. PMID 12127922 DOI: 10.1053/Euhj.2001.3074  0.386
2002 Griffin JH, Zlokovic B, Fernández JA. Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke Seminars in Hematology. 39: 197-205. PMID 12124682 DOI: 10.1053/Shem.2002.34093  0.437
2002 Gale AJ, Tsavaler A, Griffin JH. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Journal of Biological Chemistry. 277: 28836-28840. PMID 12063259 DOI: 10.1074/Jbc.M204363200  0.39
2002 Simmelink MJA, Fernández JA, Derksen RHWM, Griffin JH, De Groot PG. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II British Journal of Haematology. 117: 676-684. PMID 12028041 DOI: 10.1046/J.1365-2141.2002.03447.X  0.405
2002 Yegneswaran S, Fernández JA, Griffin JH, Dawson PE. Factor Va increases the affinity of factor Xa for prothrombin: A binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry and Biology. 9: 485-494. PMID 11983337 DOI: 10.1016/S1074-5521(02)00132-1  0.342
2002 Deguchi H, Fernández JA, Griffin JH. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S Journal of Biological Chemistry. 277: 8861-8865. PMID 11741960 DOI: 10.1074/Jbc.M110252200  0.428
2001 Griffin JH, Fernández JA, Deguchi H. Plasma lipoproteins, hemostasis and thrombosis Thrombosis and Haemostasis. 86: 386-394. PMID 11487028 DOI: 10.1055/S-0037-1616236  0.346
2001 Petäjä J, Pesonen E, Fernández JA, Griffin JH, Repo H, Jansson SE, Vento AE, Juhani Rämö O. Activated protein C and inflammation in human myocardium after heart surgery American Journal of Hematology. 67: 210-212. PMID 11391722 DOI: 10.1002/Ajh.1110  0.396
2001 Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation. 103: 1799-1805. PMID 11282913 DOI: 10.1161/01.Cir.103.13.1799  0.372
2001 Deguchi H, Fernández JA, Pabinger I, Heit JA, Griffin JH. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway Blood. 97: 1907-1914. PMID 11264150 DOI: 10.1182/Blood.V97.7.1907  0.443
2001 Rintelen C, Yegneswaran S, Griffin JH. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation Thrombosis and Haemostasis. 85: 274-279. PMID 11246547 DOI: 10.1055/S-0037-1615694  0.437
2000 Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. Three-dimensional model of coagulation factor Va bound to activated protein C. Thrombosis and Haemostasis. 84: 849-57. PMID 11127867 DOI: 10.1055/S-0037-1614127  0.333
2000 Hackeng TM, Fernández JA, Dawson PE, Kent SB, Griffin JH. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America. 97: 14074-8. PMID 11106381 DOI: 10.1073/Pnas.260239797  0.408
2000 Mesters RM, Helterbrand J, Yan SB, Utterback BG, Chao YB, Fernandez JA, Griffin JH, Hartman DL. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Critical Care Medicine. 28: 2209-2216. PMID 10921542 DOI: 10.1097/00003246-200007000-00005  0.369
2000 Hackeng TM, Yegneswaran S, Johnson AE, Griffin JH. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal. 349: 757-764. PMID 10903136 DOI: 10.1042/Bj3490757  0.427
2000 Marx PF, Hackeng TM, Dawson PE, Griffin JH, Meijers JCM, Bouma BN. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry. 275: 12410-12415. PMID 10777524 DOI: 10.1074/Jbc.275.17.12410  0.354
2000 Fernández JA, Kojima K, Petäjä J, Hackeng TM, Griffin JH. Cardiolipin enhances protein C pathway anticoagulant activity. Blood Cells, Molecules & Diseases. 26: 115-23. PMID 10753602 DOI: 10.1006/Bcmd.2000.0285  0.465
2000 Deguchi H, Fernandez JA, Hackeng TM, Banka CL, Griffin JH. Cardiolipin is a normal component of human plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 97: 1743-8. PMID 10677528 DOI: 10.1073/Pnas.97.4.1743  0.367
2000 Gale AJ, Pellequer JL, Getzoff ED, Griffin JH. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII. Thrombosis and Haemostasis. 83: 78-85. PMID 10669159 DOI: 10.1055/S-0037-1613761  0.319
2000 Gale AJ, Heeb MJ, Griffin JH. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Blood. 96: 585-593. DOI: 10.1182/Blood.V96.2.585.014K30_585_593  0.349
1999 Heeb MJ, Kojima Y, Rosing J, Tans G, Griffin JH. C-terminal residues 621-635 of protein S are essential for binding to factor Va Journal of Biological Chemistry. 274: 36187-36192. PMID 10593904 DOI: 10.1074/Jbc.274.51.36187  0.427
1999 Petaja J, Pesonen E, Fernandez JA, Vento AE, Ramo OJ, Griffin JH, Schmidt AM, Rose EA, Stern DM. Cardiopulmonary bypass and activation of antithrombotic plasma protein C Journal of Thoracic and Cardiovascular Surgery. 118: 422-431. PMID 10469954 DOI: 10.1016/S0022-5223(99)70178-9  0.42
1999 Hackeng TM, Griffin JH, Dawson PE. Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America. 96: 10068-10073. PMID 10468563 DOI: 10.1073/Pnas.96.18.10068  0.324
1999 Lentz SR, Fernández JA, Griffin JH, Piegors DJ, Erger RA, Malinow MR, Heistad DD. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1744-50. PMID 10397693 DOI: 10.1161/01.Atv.19.7.1744  0.307
1999 Macko RF, Killewich LA, Fernández JA, Cox DK, Gruber A, Griffin JH. Brain-specific protein C activation during carotid artery occlusion in humans. Stroke. 30: 542-5. PMID 10066849 DOI: 10.1161/01.Str.30.3.542  0.407
1999 Griffin JH, Kojima K, Banka CL, Curtiss LK, Fernández JA. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C. The Journal of Clinical Investigation. 103: 219-27. PMID 9916134 DOI: 10.1172/Jci5006  0.415
1999 Petäjä J, Hakala L, Rasi V, Griffin JH. Circulating activated protein C in subjects with heterozygous Gln506-factor V. Haemostasis. 28: 31-6. PMID 9885368 DOI: 10.1159/000022381  0.438
1999 Petäjä J, Fernández JA, Fellman V, Griffin JH. Upregulation of the antithrombotic protein C pathway at birth. Pediatric Hematology and Oncology. 15: 489-99. PMID 9842642 DOI: 10.3109/08880019809018310  0.387
1999 Zivelin A, Gitel S, Griffin JH, Xu X, Fernandez JA, Martinowitz U, Cohen Y, Halkin H, Seligsohn U, Inbal A. Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C Blood. 94: 895-901. DOI: 10.1182/Blood.V94.3.895.415K01_895_901  0.432
1999 Mosnier L, Meijers J, Griffin J, Bouma B. Factor XI Dependent and Independent Activation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in Plasma Associated with Clot Formation Thrombosis and Haemostasis. 82: 1703-1708. DOI: 10.1055/S-0037-1614902  0.41
1999 Fernández J, Petäjä J, Griffin J. Dermatan Sulfate and LMW Heparin Enhance the Anticoagulant Action of Activated Protein C Thrombosis and Haemostasis. 82: 1462-1468. DOI: 10.1055/S-0037-1614856  0.41
1998 Mounier CM, Hackeng TM, Schaeffer F, Faure G, Bon C, Griffin JH. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa. The Journal of Biological Chemistry. 273: 23764-72. PMID 9726985 DOI: 10.1074/Jbc.273.37.23764  0.387
1998 Hackeng TM, Dawson PE, Kent SB, Griffin JH. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers. 46: 53-63. PMID 9664841 DOI: 10.1002/(Sici)1097-0282(199808)46:2<53::Aid-Bip1>3.0.Co;2-W  0.38
1998 Fernández JA, Griffin JH, Chang GTG, Stam J, Reitsma PH, Bertina RM, Bouma BN. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein Blood Cells, Molecules and Diseases. 24: 101-113. PMID 9628846 DOI: 10.1006/Bcmd.1998.0175  0.357
1998 Kojima Y, Heeb MJ, Gale AJ, Hackeng TM, Griffin JH. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va. The Journal of Biological Chemistry. 273: 14900-5. PMID 9614093 DOI: 10.1074/Jbc.273.24.14900  0.367
1997 Petäjä JM, Griffin JH. Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled? Annals of Medicine. 29: 469-472. PMID 9562511 DOI: 10.3109/07853899709007469  0.388
1997 Wang L, Zoppè M, Hackeng TM, Griffin JH, Lee KF, Verma IM. A factor IX-deficient mouse model for hemophilia B gene therapy. Proceedings of the National Academy of Sciences of the United States of America. 94: 11563-6. PMID 9326649 DOI: 10.1073/Pnas.94.21.11563  0.335
1997 Smiley ST, Boyer SN, Heeb MJ, Griffin JH, Grusby MJ. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 11484-9. PMID 9326636 DOI: 10.1073/Pnas.94.21.11484  0.333
1997 Fernández JA, Petäjä J, Gruber A, Griffin JH. Activated protein C correlates inversely with thrombin levels in resting healthy individuals. American Journal of Hematology. 56: 29-31. PMID 9298864 DOI: 10.1002/(Sici)1096-8652(199709)56:1<29::Aid-Ajh6>3.0.Co;2-4  0.419
1997 Hackeng TM, Mounier CM, Bon C, Dawson PE, Griffin JH, Kent SB. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2. Proceedings of the National Academy of Sciences of the United States of America. 94: 7845-50. PMID 9223275 DOI: 10.1073/Pnas.94.15.7845  0.339
1997 Petäjä J, Fernández JA, Gruber A, Griffin JH. Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C. The Journal of Clinical Investigation. 99: 2655-63. PMID 9169495 DOI: 10.1172/Jci119454  0.448
1997 Fernández JA, Heeb MJ, Radtke KP, Griffin JH. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor. Biology of Reproduction. 56: 757-63. PMID 9047022 DOI: 10.1095/Biolreprod56.3.757  0.332
1997 Gale AJ, Sun X, Heeb MJ, Griffin JH. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Science : a Publication of the Protein Society. 6: 132-40. PMID 9007985 DOI: 10.1002/Pro.5560060115  0.488
1997 Heeb MJ, Kojima Y, Hackeng TM, Griffin JH. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. Protein Science : a Publication of the Protein Society. 5: 1883-9. PMID 8880912 DOI: 10.1002/Pro.5560050914  0.435
1997 Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B, Eldor A, Seligsohn U. A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis Blood. 89: 397-402. DOI: 10.1182/Blood.V89.2.397  0.319
1997 Fernández JA, Hackeng TM, Kojima K, Griffin JH. The Carbohydrate Moiety of Factor V Modulates Inactivation by Activated Protein C Blood. 89: 4348-4354. DOI: 10.1182/Blood.V89.12.4348  0.356
1997 Schwartz EJ, Goldberg J, Clayberger C, Krensky AM, Griffin JH. Structure-activity studies of CTL inhibitory peptides derived from HLA class I molecules Bioorganic and Medicinal Chemistry Letters. 7: 37-40. DOI: 10.1016/S0960-894X(96)00576-8  0.319
1996 Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R, Quismorio FP, Weiner JM, Fisher M. Impairments of the protein C system and fibrinolysis in infection-associated stroke. Stroke; a Journal of Cerebral Circulation. 27: 2005-11. PMID 8898806 DOI: 10.1161/01.Str.27.11.2005  0.327
1996 Petäjä J, Lundström U, Sairanen H, Marttinen E, Griffin JH. Central venous thrombosis after cardiac operations in children. The Journal of Thoracic and Cardiovascular Surgery. 112: 883-9. PMID 8873713 DOI: 10.1016/S0022-5223(96)70087-9  0.312
1996 Villoutreix BO, Fernández JA, Teleman O, Griffin JH. Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S. Protein Engineering. 8: 1253-8. PMID 8869637 DOI: 10.1093/Protein/8.12.1253  0.32
1996 Sifontes MT, Nuss R, Jacobson LJ, Griffin JH, Manco-Johnson MJ. Thrombosis in otherwise well children with the factor V Leiden mutation Journal of Pediatrics. 128: 324-328. PMID 8774498 DOI: 10.1016/S0022-3476(96)70275-5  0.333
1996 Gillespie DL, Carrington LR, Griffin JH, Alving BM. Resistance to Activated Protein C: A Common Inherited Cause of Venous Thrombosis Annals of Vascular Surgery. 10: 174-177. PMID 8733870 DOI: 10.1007/Bf02000762  0.403
1996 Fisher M, Fernandez JA, Ameriso SF, Xie D, Gruber A, Paganini-Hill A, Griffin JH. Activated protein C resistance in ischemic stroke not due to factor V arginine506-->glutamine mutation. Stroke. 27: 1163-6. PMID 8685921 DOI: 10.1161/01.Str.27.7.1163  0.343
1996 Greengard JS, Xu X, Gandrille S, Griffin JH. Alternative PCR method for diagnosis of mutation causing activated protein C resistant Gln506-factor V. Thrombosis Research. 80: 441-3. PMID 8588206 DOI: 10.1016/0049-3848(95)00197-Y  0.357
1996 Calkins T, Greengard J, Griffin JH, Bylund D. Anticoagulant response to activated protein C: method validation and assay comparison. Journal of Clinical Laboratory Analysis. 9: 418-23. PMID 8587012 DOI: 10.1002/Jcla.1860090614  0.328
1996 Radtke K, Greengard JS, Fernández JA, Villoutreix BO, Griffin JH. A Two-Allele Polymorphism in Protein C Inhibitor with Varying Frequencies in Different Ethnic Populations Thrombosis and Haemostasis. 75: 062-069. DOI: 10.1055/S-0038-1650222  0.343
1995 Greengard JS, Fernandez JA, Radtke KP, Griffin JH. Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C. The Biochemical Journal. 397-403. PMID 7832752 DOI: 10.1042/Bj3050397  0.418
1995 Fernández JA, Villoutreix BO, Hackeng TM, Griffin JH, Bouma BN. Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies. Biochemistry. 33: 11073-8. PMID 7727359 DOI: 10.1021/Bi00203A003  0.325
1995 Gandrille S, Greengard J, Alhenc-Gelas M, Juhan-Vague I, Abgrall J, Jude B, Griffin J, Aiach M. Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM Blood. 86: 219-224. DOI: 10.1182/Blood.V86.1.219.Bloodjournal861219  0.392
1995 Le D, Griffin J, Greengard J, Mujumdar V, Rapaport S. Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant Blood. 85: 1704-1711. DOI: 10.1182/Blood.V85.7.1704.Bloodjournal8571704  0.389
1995 Heeb M, Kojima Y, Greengard J, Griffin J. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V Blood. 85: 3405-3411. DOI: 10.1182/Blood.V85.12.3405.Bloodjournal85123405  0.392
1995 Radtke K, Fernández JA, Villoutreix BO, Greengard JS, Griffin JH. Characterization of a cDNA for Rhesus Monkey Protein C Inhibitor – Evidence for N-Terminal Involvement in Heparin Stimulation Thrombosis and Haemostasis. 74: 1079-1087. DOI: 10.1055/S-0038-1649885  0.408
1995 Griffin JH, Heeb MJ, Kojima Y, Fernández JA, Kojima K, Hackeng TM, Greengard JS. Activated Protein C Resistance: Molecular Mechanisms Thrombosis and Haemostasis. 74: 444-448. DOI: 10.1055/S-0038-1642719  0.371
1994 Mesters RM, Heeb MJ, Griffin JH. A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. Biochemistry. 32: 12656-63. PMID 8251484 DOI: 10.1021/Bi00210A014  0.38
1994 Greengard JS, Fisher CL, Villoutreix B, Griffin JH. Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain. Proteins. 18: 367-80. PMID 8208728 DOI: 10.1002/Prot.340180407  0.364
1994 Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa Proceedings of the National Academy of Sciences of the United States of America. 91: 2728-2732. PMID 8146182 DOI: 10.1073/Pnas.91.7.2728  0.403
1994 Tsay W, Greengard JS, Griffin JH. Exonic polymorphisms in the protein C gene: interethnic comparison between Caucasians and Asians Human Genetics. 94: 177-178. PMID 8045564 DOI: 10.1007/Bf00202865  0.324
1994 Fisher CL, Greengard JS, Griffin JH. Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. Protein Science : a Publication of the Protein Society. 3: 588-99. PMID 8003977 DOI: 10.1002/Pro.5560030407  0.404
1994 Greengard JS, Eichinger S, Griffin JH, Bauer KA. Brief report: Variability of thrombosis among homozygous siblings with resistance to activated protein C due to an Arg→Gln mutation in the gene for factor V New England Journal of Medicine. 331: 1559-1562. PMID 7969326 DOI: 10.1056/Nejm199412083312305  0.45
1994 Greengard J, Sun X, Xu X, Fernandez J, Griffin J, Evatt B. Activated protein C resistance caused by Arg506Gln mutation in factor Va The Lancet. 343: 1361-1362. PMID 7910348 DOI: 10.1016/S0140-6736(94)92497-X  0.373
1994 Gruber A, Mori E, del Zoppo G, Waxman L, Griffin J. Alteration of fibrin network by activated protein C Blood. 83: 2541-2548. DOI: 10.1182/Blood.V83.9.2541.2541  0.397
1994 Sun X, Evatt B, Griffin J. Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia Blood. 83: 3120-3125. DOI: 10.1182/Blood.V83.11.3120.Bloodjournal83113120  0.365
1994 Greengard JS, Griffin JH, Fisher CL. Possible Structural Implications of 20 Mutations in the Protein C Protease Domain Thrombosis and Haemostasis. 72: 869-873. DOI: 10.1055/S-0038-1648976  0.32
1993 Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates Journal of Clinical Investigation. 92: 2003-2012. PMID 8408654 DOI: 10.1172/Jci116795  0.426
1993 Mesters RM, Heeb MJ, Griffin JH. Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. Protein Science : a Publication of the Protein Society. 2: 1482-9. PMID 8401232 DOI: 10.1002/Pro.5560020912  0.376
1993 Gruber A, Pál A, Kiss RG, Sas G, Griffin JH. Generation of activated protein C during thrombolysis. Lancet (London, England). 342: 1275-6. PMID 7901587 DOI: 10.1016/0140-6736(93)92364-Y  0.403
1993 Griffin J, Evatt B, Wideman C, Fernandez J. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood. 82: 1989-1993. DOI: 10.1182/Blood.V82.7.1989.Bloodjournal8271989  0.421
1993 Griffin J, Evatt B, Wideman C, Fernandez J. Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments] Blood. 82: 1989-1993. DOI: 10.1182/blood.v82.7.1989.1989  0.308
1993 Conard J, Bauer K, Gruber A, Griffin J, Schwarz H, Horellou M, Samama M, Rosenberg R. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency Blood. 82: 1159-1164. DOI: 10.1182/Blood.V82.4.1159.Bloodjournal8241159  0.455
1993 Conard J, Bauer K, Gruber A, Griffin J, Schwarz H, Horellou M, Samama M, Rosenberg R. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency Blood. 82: 1159-1164. DOI: 10.1182/BLOOD.V82.4.1159.BLOODJOURNAL8241159  0.349
1993 Tsay W, Greengard JS, Montgomery RR, McPherson RA, Fucci JC, Koerper MA, Coughlin J, Griffin JH. Genetic mutations in ten unrelated American patients with symptomatic Type 1 protein C deficiency Blood Coagulation & Fibrinolysis. 4: 791-796. DOI: 10.1097/00001721-199304050-00017  0.323
1993 España F, Estellés A, Fernández PJ, Gilabert J, Sánchez-Cuenca J, Griffin JH. Evidence for the Regulation of Urokinase and Tissue Type Plasminogen Activators by the Serpin, Protein C Inhibitor, in Semen and Blood Plasma Thrombosis and Haemostasis. 70: 0989-0994. DOI: 10.1055/S-0038-1649712  0.366
1992 Bakker HM, Tans G, Janssen-Claessen T, Thomassen MCLGD, Hemker HC, Griffin JH, Rosing J. The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C European Journal of Biochemistry. 208: 171-178. PMID 1387359 DOI: 10.1111/J.1432-1033.1992.Tb17171.X  0.371
1992 Gruber A, Griffin J. Direct detection of activated protein C in blood from human subjects Blood. 79: 2340-2348. DOI: 10.1182/Blood.V79.9.2340.Bloodjournal7992340  0.371
1992 Griffin J, Gruber A, Fernandez J. Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin Blood. 79: 3203-3211. DOI: 10.1182/Blood.V79.12.3203.Bloodjournal79123203  0.35
1992 Gruber A, Harker L, Griffin J, Esmond C, Hanson S. Induced anticoagulant therapy by endogenous activated protein C (APC) Thrombosis Research. 65: S126. DOI: 10.1016/0049-3848(92)90565-R  0.391
1991 España F, Gilabert J, Aznar J, Estellés A, Kobayashi T, Griffin JH. Complexes of activated protein C with α1-antitrypsin in normal pregnancy and in severe preeclampsia American Journal of Obstetrics and Gynecology. 164: 1310-1316. PMID 1852102 DOI: 10.1016/0002-9378(91)90706-W  0.402
1991 Gruber A, Harker LA, Hanson SR, Kelly AB, Griffin JH. Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates Circulation. 84: 2454-2462. PMID 1835678 DOI: 10.1161/01.Cir.84.6.2454  0.388
1991 Vicente V, Espana F, Tabernero D, Estelles A, Aznar J, Hendl S, Griffin J. Evidence of activation of the protein C pathway during acute vascular damage induced by Mediterranean spotted fever Blood. 78: 416-422. DOI: 10.1182/Blood.V78.2.416.416  0.42
1991 Vicente V, Espana F, Tabernero D, Estelles A, Aznar J, Hendl S, Griffin J. Evidence of activation of the protein C pathway during acute vascular damage induced by Mediterranean spotted fever Blood. 78: 416-422. DOI: 10.1182/BLOOD.V78.2.416.416  0.307
1991 Espana F, Gruber A, Heeb M, Hanson S, Harker L, Griffin J. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons Blood. 77: 1754-1760. DOI: 10.1182/Blood.V77.8.1754.Bloodjournal7781754  0.328
1991 Tans G, Rosing J, Thomassen M, Heeb M, Zwaal R, Griffin J. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles Blood. 77: 2641-2648. DOI: 10.1182/Blood.V77.12.2641.Bloodjournal77122641  0.344
1991 España F, Estelles A, Griffin JH, Aznar J. Interaction of Plasma Kallikrein with Protein C Inhibitor in Purified Mixtures and in Plasma Thrombosis and Haemostasis. 65: 046-051. DOI: 10.1055/S-0038-1647452  0.372
1990 Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis Circulation. 82: 578-585. PMID 2372904 DOI: 10.1161/01.Cir.82.2.578  0.366
1990 Mack DP, Sluka JP, Shin JA, Griffin JH, Simon MI, Dervan PB. Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. Biochemistry. 29: 6561-7. PMID 2204416 DOI: 10.1021/Bi00480A003  0.463
1990 España F, Vicente V, Tabernero D, Scharrer I, Griffin JH. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis Research. 59: 593-608. PMID 2173167 DOI: 10.1016/0049-3848(90)90418-C  0.358
1990 Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, España F, Tainer JA. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor Proceedings of the National Academy of Sciences of the United States of America. 87: 8506-8510. PMID 2172989 DOI: 10.1073/Pnas.87.21.8506  0.372
1990 Sluka JP, Griffin JH, Mack DP, Dervan PB. Reagents and methods for the solid-phase synthesis of protein-EDTA for use in affinity cleaving Journal of the American Chemical Society. 112: 6369-6374. DOI: 10.1021/Ja00173A027  0.496
1990 España F, Glabert J, Aznar J, Estellés A, Kobayashi T, Griffin J. Increased levels of complexes of activated protein C with in normal pregnancy and in preeclampsia Fibrinolysis. 4: 15. DOI: 10.1016/0268-9499(90)90064-Q  0.348
1989 Heeb MJ, Schwarz HP, White T, Lämmle B, Berrettini M, Griffin JH. Immunoblotting studies of the molecular forms of protein C in plasma. Thrombosis Research. 52: 33-43. PMID 3201394 DOI: 10.1016/0049-3848(88)90038-2  0.386
1989 Gladson CL, Schleef RR, Binder BR, Loskutoff DJ, Griffin JH. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood. 74: 173-81. PMID 2787675 DOI: 10.1182/Blood.V74.1.173.Bloodjournal741173  0.448
1989 España F, Griffin JH. Determination of functional and antigenic protein C inhibitor and its complexes with activated protein C in plasma by ELISA's. Thrombosis Research. 55: 671-82. PMID 2551066 DOI: 10.1016/0049-3848(89)90298-3  0.398
1989 España F, Berrettini M, Griffin JH. Purification and characterization of plasma protein C inhibitor. Thrombosis Research. 55: 369-84. PMID 2551064 DOI: 10.1016/0049-3848(89)90069-8  0.347
1989 Espana F, Estelles A, Griffin JH, Aznar J, Gilabert J. Aprotinin (Trasylol) is a competitive inhibitor of activated protein C Thrombosis Research. 56: 751-756. PMID 2483763 DOI: 10.1016/0049-3848(89)90292-2  0.411
1989 Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin J, Binder B. Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo Blood. 74: 722-728. DOI: 10.1182/Blood.V74.2.722.Bloodjournal742722  0.373
1989 Schwarz H, Heeb M, Lottenberg R, Roberts H, Griffin J. Familial protein S deficiency with a variant protein S molecule in plasma and platelets Blood. 74: 213-221. DOI: 10.1182/Blood.V74.1.213.Bloodjournal741213  0.388
1989 Gruber A, Griffin J, Harker L, Hanson S. Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model Blood. 73: 639-642. DOI: 10.1182/Blood.V73.3.639.639  0.383
1989 Heeb M, Mosher D, Griffin J. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation Blood. 73: 455-461. DOI: 10.1182/Blood.V73.2.455.Bloodjournal732455  0.444
1989 Heeb M, Mosher D, Griffin J. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation Blood. 73: 455-461. DOI: 10.1182/BLOOD.V73.2.455.BLOODJOURNAL732455  0.335
1989 Heeb M, Espana F, Griffin J. Inhibition and complexation of activated protein C by two major inhibitors in plasma Blood. 73: 446-454. DOI: 10.1182/Blood.V73.2.446.Bloodjournal732446  0.394
1989 Geiger M, White TM, Griffin JH. Functional Assays for Protein C Activity and Protein C Inhibitor Activity in Plasma Thrombosis and Haemostasis. 61: 086-092. DOI: 10.1055/S-0038-1646532  0.421
1988 Tans G, Verkleij AJ, Yu J, Griffin JH. Sulfatide bilayers as a surface for contact activation in human plasma. Biochemical and Biophysical Research Communications. 149: 1002-7. PMID 3426605 DOI: 10.1016/0006-291X(87)90508-0  0.34
1988 Geiger M, Heeb MJ, Binder BR, Griffin JH. Competition of activated protein C and urokinase for a heparin-dependent inhibitor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2263-7. PMID 3350241 DOI: 10.1096/Fasebj.2.7.3350241  0.404
1988 Alter SC, Lämmle B, Griffin JH, Schwartz LB. Tryptase from human mast cells does not activate purified human Hageman Factor Clinical & Experimental Allergy. 18: 151-156. PMID 3284668 DOI: 10.1111/J.1365-2222.1988.Tb02854.X  0.337
1988 Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thrombosis and Haemostasis. 59: 18-22. PMID 2966450 DOI: 10.1055/S-0038-1642558  0.396
1988 Schwarz H, Muntean W, Watzke H, Richter B, Griffin J. Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates Blood. 71: 562-565. DOI: 10.1182/Blood.V71.3.562.Bloodjournal713562  0.421
1988 Schwarz H, Muntean W, Watzke H, Richter B, Griffin J. Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates Blood. 71: 562-565. DOI: 10.1182/BLOOD.V71.3.562.BLOODJOURNAL713562  0.307
1988 Lämmle B, Zuraw BL, Heeb MJ, Schwarz HP, Berrettini M, Curd JG, Griffin JH. Detection and Quantitation of Cleaved and Uncleaved High Molecular Weight Kininogen in Plasma by Ligand Blotting with Radiolabeled Plasma Prekallikrein or Factor XI Thrombosis and Haemostasis. 59: 151-161. DOI: 10.1055/S-0038-1642745  0.351
1988 Geiger M, Griffin J, Binder B. 127 Plasminogen activator inhibitor 3 (PAI-3, protein C inhibitor): Purification, characterization and specificity Fibrinolysis. 2: 56. DOI: 10.1016/0268-9499(88)90474-2  0.39
1988 Geiger M, Huber K, Wojta J, Stingl L, Espana F, Griffin J, Binder B. 126 Complex formation between urokinase (uPA) and plasma protein C inhibitor (PCI) in vivo Fibrinolysis. 2: 56. DOI: 10.1016/0268-9499(88)90473-0  0.391
1988 Sakata Y, Griffin J, Loskutoff D. Effect of activated protein c on the fibrinolytic components released by cultured bovine aortic endothelial cells Fibrinolysis. 2: 7-15. DOI: 10.1016/0268-9499(88)90059-8  0.364
1988 GRIFFIN JH, DERVAN PB. ChemInform Abstract: Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA. Cheminform. 19. DOI: 10.1002/chin.198808340  0.381
1987 Tans G, Janssen-Claessen T, Rosing J, Griffin JH. Studies on the effect of serine protease inhibitors on activated contact factors. Application in amidolytic assays for factor XIIa, plasma kallikrein and factor XIa. European Journal of Biochemistry. 164: 637-42. PMID 3552674 DOI: 10.1111/J.1432-1033.1987.Tb11174.X  0.344
1987 Lämmle B, Berrettini M, Griffin JH. Immunoblotting studies of coagulation factor XII, plasma prekallikrein, and high molecular weight kininogen. Seminars in Thrombosis and Hemostasis. 13: 106-14. PMID 3494310 DOI: 10.1055/S-2007-1003480  0.348
1987 Gladson CL, Groncy P, Griffin JH. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency. Archives of Dermatology. 123: 1701a-1706a. PMID 2961308 DOI: 10.1001/Archderm.1987.01660360157029  0.375
1987 Griffin JH, Dervan PB. Metalloregulation in the sequence specific binding of synthetic molecules to DNA Journal of the American Chemical Society. 109: 6840-6842. DOI: 10.1021/Ja00256A043  0.464
1986 Cembrowski GS, Griffin JH, Mosher DF. Diagnostic Efficacy of Six Plasma Proteins in Evaluating Consumptive Coagulopathies: Use of Receiver Operating Characteristic Curves to Compare Antithrombin III, Plasminogen, α2-Plasmin Inhibitor, Fibronectin, Prothrombin, and Protein C Archives of Internal Medicine. 146: 1997-2002. PMID 3767544 DOI: 10.1001/Archinte.1986.00360220159027  0.362
1986 Lämmle B, Berrettini M, Griffin JH. Enhanced specificity of immunoblotting using radiolabeled antigen overlay: studies of blood coagulation factor XII and prekallikrein in plasma. Analytical Biochemistry. 156: 118-25. PMID 3638135 DOI: 10.1016/0003-2697(86)90162-4  0.335
1986 Bouma BN, Kerbiriou DM, Baker J, Griffin JH. Characterization of a variant prekallikrein, prekallikrein Long Beach, from a family with mixed cross-reacting material-positive and cross-reacting material-negative prekallikrein deficiency. The Journal of Clinical Investigation. 78: 170-6. PMID 3487556 DOI: 10.1172/Jci112547  0.335
1986 Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood. 68: 1218-23. PMID 3096399 DOI: 10.1182/Blood.V68.6.1218.1218  0.459
1986 Greengard JS, Heeb MJ, Ersdal E, Walsh PN, Griffin JH. Binding of coagulation factor XI to washed human platelets. Biochemistry. 25: 3884-90. PMID 3017409 DOI: 10.1021/Bi00361A022  0.3
1986 Bezeaud A, Drouet L, Leverger G, Griffin JH, Guillin MC. Effect of L-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors. The Journal of Pediatrics. 108: 698-701. PMID 2939229 DOI: 10.1016/S0022-3476(86)81044-7  0.343
1986 Berrettini M, Lammle B, White T, Heeb M, Schwarz H, Zuraw B, Curd J, Griffin J. Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies Blood. 68: 455-462. DOI: 10.1182/Blood.V68.2.455.455  0.334
1986 Griffin JH, Dervan PB. Specific sequence-specific recognition of right-handed double-helical DNA by (2S,3S)- and (2R,3R)-dihydroxybis(netropsin)succinamide Journal of the American Chemical Society. 108: 5008-5009. DOI: 10.1021/Ja00276A052  0.454
1986 Bouma BN, Griffin JH. Chapter 5A Initiation mechanisms: The contact activation system in plasma New Comprehensive Biochemistry. 13: 103-128. DOI: 10.1016/S0167-7306(08)60050-2  0.419
1986 GRIFFIN JH, DERVAN PB. ChemInform Abstract: Sequence-Specific Chiral Recognition of Right-Handed Double-Helical DNA by (2S,3S)- (Ia) and (2R,3R)-Dihydroxybis(netropsin)succinamide (Ib). Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198650085  0.364
1985 Gardiner JE, Griffin JH. Studies on human protein C inhibitor in normal and Factor V/VIII deficient plasmas. Thrombosis Research. 36: 197-203. PMID 6549082 DOI: 10.1016/0049-3848(84)90219-6  0.436
1985 Griffin JH, Bezeaud A, Evatt B, Mosher D. Studies of protein C in thromboembolic disease. La Ricerca in Clinica E in Laboratorio. 14: 469-73. PMID 6395293 DOI: 10.1007/Bf02904873  0.338
1985 Schwartz LB, Bradford T, Griffin JH. The effect of tryptase from human mast cells on human prekallikrein. Biochemical and Biophysical Research Communications. 129: 76-81. PMID 3890857 DOI: 10.1016/0006-291X(85)91405-6  0.343
1985 Rosing J, Tans G, Griffin JH. Surface-dependent activation of human factor XII (Hageman factor) by kallikrein and its light chain. European Journal of Biochemistry. 151: 531-8. PMID 3875484 DOI: 10.1111/J.1432-1033.1985.Tb09135.X  0.318
1985 Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proceedings of the National Academy of Sciences of the United States of America. 82: 1121-5. PMID 3871946 DOI: 10.1073/Pnas.82.4.1121  0.39
1985 Schwarz H, Heeb M, Wencel-Drake J, Griffin J. Identification and quantitation of protein S in human platelets Blood. 66: 1452-1455. DOI: 10.1182/Blood.V66.6.1452.1452  0.377
1984 Griffin JH. Clinical studies of protein C. Seminars in Thrombosis and Hemostasis. 10: 162-6. PMID 6377499 DOI: 10.1055/S-2007-1004419  0.418
1984 Schwarz H, Fischer M, Hopmeier P, Batard M, Griffin J. Plasma protein S deficiency in familial thrombotic disease Blood. 64: 1297-1300. DOI: 10.1182/Blood.V64.6.1297.Bloodjournal6461297  0.395
1984 Fulcher C, Gardiner J, Griffin J, Zimmerman T. Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V Blood. 63: 486-489. DOI: 10.1182/Blood.V63.2.486.Bloodjournal632486  0.421
1983 van der Graaf F, Koedam JA, Griffin JH, Bouma BN. Interaction of human plasma kallikrein and its light chain with C1 inhibitor. Biochemistry. 22: 4860-6. PMID 6556071 DOI: 10.1021/Bi00289A037  0.312
1983 Miles LA, Greengard JS, Griffin JH. A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Thrombosis Research. 29: 407-17. PMID 6344314 DOI: 10.1016/0049-3848(83)90244-X  0.353
1983 Branson HE, Marble R, Katz J, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant The Lancet. 322: 1165-1168. PMID 6139528 DOI: 10.1016/S0140-6736(83)91216-3  0.377
1983 Bouma B, Vlooswijk R, Griffin J. Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen Blood. 62: 1123-1131. DOI: 10.1182/Blood.V62.5.1123.1123  0.343
1982 Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation Blood. 60: 261-264. PMID 6896290  0.324
1982 Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. The Journal of Clinical Investigation. 68: 1370-3. PMID 6895379 DOI: 10.1172/Jci110385  0.389
1982 Cochrane CG, Griffin JH. The biochemistry and pathophysiology of the contact system of plasma. Advances in Immunology. 33: 241-306. PMID 6182767 DOI: 10.1016/S0065-2776(08)60837-8  0.396
1982 Marlar R, Kleiss A, Griffin J. An alternative extrinsic pathway of human blood coagulation Blood. 60: 1353-1358. DOI: 10.1182/Blood.V60.6.1353.Bloodjournal6061353  0.365
1982 Griffin J, Mosher D, Zimmerman T, Kleiss A. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation Blood. 60: 261-264. DOI: 10.1182/Blood.V60.1.261.261  0.435
1982 Marlar R, Kleiss A, Griffin J. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme Blood. 59: 1067-1072. DOI: 10.1182/Blood.V59.5.1067.Bloodjournal5951067  0.393
1982 Tans G, Griffin J. Properties of sulfatides in factor-XII-dependent contact activation Blood. 59: 69-75. DOI: 10.1182/Blood.V59.1.69.Bloodjournal59169  0.4
1981 Walsh PN, Griffin JH. Platelet-coagulant protein interactions in contact activation. Annals of the New York Academy of Sciences. 370: 241-52. PMID 7023319 DOI: 10.1111/J.1749-6632.1981.Tb29737.X  0.362
1981 Marlar RA, Griffin JH. Alternative pathways of thromboplastin-dependent activation of human factor X in plasma. Annals of the New York Academy of Sciences. 370: 325-35. PMID 6943963 DOI: 10.1111/J.1749-6632.1981.Tb29745.X  0.364
1981 Marlar RA, Kleiss AJ, Griffin JH. Human protein C: inactivation of factors V and VIII in plasma by the activated molecule. Annals of the New York Academy of Sciences. 370: 303-10. PMID 6791548 DOI: 10.1111/J.1749-6632.1981.Tb29743.X  0.42
1981 Marlar RA, Griffin JH. Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease. The Journal of Clinical Investigation. 66: 1186-9. PMID 6253526 DOI: 10.1172/Jci109952  0.44
1981 Miles L, Burnier J, Verlander M, Goodman M, Kleiss A, Griffin J. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents Blood. 57: 1015-1024. DOI: 10.1182/Blood.V57.6.1015.1015  0.327
1981 Walsh P, Griffin J. Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI Blood. 57: 106-118. DOI: 10.1182/Blood.V57.1.106.Bloodjournal571106  0.332
1980 Bouma BN, Miles LA, Beretta G, Griffin JH. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry. 19: 1151-60. PMID 6768384 DOI: 10.1021/Bi00547A018  0.392
1980 Wiggins RC, Loskutoff DJ, Cochrane CG, Griffin JH, Edgington TS. Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells. The Journal of Clinical Investigation. 65: 197-206. PMID 6444222 DOI: 10.1172/Jci109651  0.351
1979 Seligsohn U, Osterud B, Griffin JH, Rapaport SI. Evidence for the participation of both activated factor XII and activated factor IX in cold-promoted activation of factor VII. Thrombosis Research. 13: 1049-56. PMID 749262 DOI: 10.1016/0049-3848(78)90233-5  0.377
1979 Wiggins RC, Cochrane CG, Griffin JH. Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII). Thrombosis Research. 15: 487-95. PMID 494157 DOI: 10.1016/0049-3848(79)90154-3  0.377
1979 Wiggins RC, Cochrane CG, Griffin JH. Rabbit blood coagulation factor XI. Purification and properties. Thrombosis Research. 15: 475-86. PMID 494156 DOI: 10.1016/0049-3848(79)90153-1  0.338
1979 Seligsohn U, Osterud B, Brown SF, Griffin JH, Rapaport SI. Activation of human factor VII in plasma and in purified systems: roles of activated factor IX, kallikrein, and activated factor XII. The Journal of Clinical Investigation. 64: 1056-65. PMID 479368 DOI: 10.1172/Jci109543  0.383
1979 Cochrane CG, Griffin JH. Molecular assembly in the contact phase of the Hageman factor system. The American Journal of Medicine. 67: 657-64. PMID 386794 DOI: 10.1016/0002-9343(79)90253-5  0.342
1978 Davis S, Furie BC, Griffin JH, Furie B. Circulating inhibitors of blood coagulation associated with procainamide‐induced lupus erythematosus American Journal of Hematology. 4: 401-407. PMID 717399 DOI: 10.1002/Ajh.2830040411  0.367
1978 Revak SD, Cochrane CG, Bouma BN, Griffin JH. Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma. The Journal of Experimental Medicine. 147: 719-29. PMID 632748 DOI: 10.1084/Jem.147.3.719  0.343
1978 Griffin JH. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proceedings of the National Academy of Sciences of the United States of America. 75: 1998-2002. PMID 273926 DOI: 10.1073/Pnas.75.4.1998  0.374
1978 Wiggins RC, Bouma BN, Cochrane CG, Griffin JH. Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein. Proceedings of the National Academy of Sciences of the United States of America. 74: 4636-40. PMID 270705 DOI: 10.1073/Pnas.74.10.4636  0.361
1977 Revak SD, Cochrane CG, Griffin JH. The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen. The Journal of Clinical Investigation. 59: 1167-75. PMID 864009 DOI: 10.1172/Jci108741  0.37
1977 Griffin JH, DiBello C, Alazard R, Nicolas P, Cohen P. Carbon-13 nuclear magnetic resonance studies of the binding of selectively 13C-enriched oxytocins to the neurophypophyseal protein, bovine neurophysin II. Biochemistry. 16: 4194-8. PMID 561612 DOI: 10.1021/Bi00638A010  0.34
1976 Griffin JH, Cochrane CG. Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor. Proceedings of the National Academy of Sciences of the United States of America. 73: 2554-8. PMID 1066663 DOI: 10.1073/Pnas.73.8.2554  0.364
1976 Griffin JH, Cochrane CG. [7] Human factor XII (Hageman factor) Methods in Enzymology. 45: 56-65. PMID 1012017 DOI: 10.1016/S0076-6879(76)45009-7  0.358
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