| Year |
Citation |
Score |
| 2020 |
Huppé CA, Blais-Lecours P, Bernatchez E, Lauzon-Joset JF, Duchaine C, Rosen H, Dion G, McNagny KM, Blanchet MR, Morissette MC, Marsolais D. S1P Contributes to Endotoxin-enhanced B Cell Functions Involved in Hypersensitivity Pneumonitis. American Journal of Respiratory Cell and Molecular Biology. PMID 32289229 DOI: 10.1165/Rcmb.2019-0339Oc |
0.413 |
|
| 2019 |
Page S, Mavrikaki M, Lintz T, Puttick D, Roberts E, Rosen H, Carroll FI, Carlezon WA, Chartoff EH. Behavioral pharmacology of novel kappa opioid receptor antagonists in rats. The International Journal of Neuropsychopharmacology. PMID 31613314 DOI: 10.1093/Ijnp/Pyz054 |
0.328 |
|
| 2019 |
Guerrero M, Urbano M, Kim EK, Gamo Albero AM, Riley S, Abgaryan L, Leaf N, Van Orden LJ, Brown SJ, Xie J, Porreca F, Cameron MD, Rosen H, Roberts E. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). Journal of Medicinal Chemistry. PMID 30707578 DOI: 10.1021/Acs.Jmedchem.8B01679 |
0.347 |
|
| 2018 |
Ogasawara D, Ichu TA, Vartabedian VF, Benthuysen J, Jing H, Reed A, Ulanovskaya OA, Hulce JJ, Roberts A, Brown S, Rosen H, Teijaro JR, Cravatt BF. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nature Chemical Biology. PMID 30420694 DOI: 10.1038/S41589-018-0155-8 |
0.33 |
|
| 2018 |
Huppé CA, Lecours PB, Lechasseur A, Gendron DR, Lemay AM, Bissonnette EY, Blanchet MR, Duchaine C, Morissette MC, Rosen H, Marsolais D. A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung. Mucosal Immunology. 11: 112-119. PMID 28422187 DOI: 10.1038/Mi.2017.37 |
0.411 |
|
| 2017 |
Song J, Dagan A, Yakhtin Z, Gatt S, Riley S, Rosen H, Or R, Almogi-Hazan O. The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes. Oncotarget. 8: 53563-53580. PMID 28881832 DOI: 10.18632/Oncotarget.18626 |
0.368 |
|
| 2017 |
Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. Journal of Neuroinflammation. 14: 111. PMID 28577576 DOI: 10.1186/S12974-017-0882-X |
0.418 |
|
| 2017 |
Tran JQ, Hartung JP, Peach RJ, Boehm MF, Rosen H, Smith H, Brooks JL, Timony GA, Olson AD, Gujrathi S, Frohna PA. Results From the First-in-Human Study With Ozanimod, a Novel, Selective Sphingosine-1-Phosphate Receptor Modulator. Journal of Clinical Pharmacology. PMID 28398597 DOI: 10.1002/Jcph.887 |
0.307 |
|
| 2017 |
Marro BS, Ware BC, Zak J, de la Torre JC, Rosen H, Oldstone MB. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 28325871 DOI: 10.1073/Pnas.1700878114 |
0.3 |
|
| 2017 |
Taylor K, Steinberg M, Peach R, Rosen H, Opiteck G, Stokes M, Clemons B, Scott F. 79 Effects of an oral selective sphingosine 1-phosphate receptor modulator in a mouse model of sle Lupus Science & Medicine. 4. DOI: 10.1136/Lupus-2017-000215.79 |
0.371 |
|
| 2016 |
Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell N, Brown JH, Miyamoto S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. Journal of Molecular and Cellular Cardiology. PMID 28017639 DOI: 10.1016/J.Yjmcc.2016.12.008 |
0.422 |
|
| 2016 |
Hur W, Rosen H, Gray NS. A benzo[b]thiophene-based selective type 4 S1P receptor agonist. Bioorganic & Medicinal Chemistry Letters. PMID 27894870 DOI: 10.1016/J.Bmcl.2016.11.050 |
0.435 |
|
| 2016 |
Skerry C, Scanlon K, Ardanuy J, Roberts D, Zhang L, Rosen H, Carbonetti NH. Therapeutic treatment with sphingosine-1-phosphate receptor 1 ligands reduces pertussis inflammatory pathology by a pertussis toxin-insensitive mechanism. The Journal of Infectious Diseases. PMID 27815382 DOI: 10.1093/Infdis/Jiw536 |
0.423 |
|
| 2016 |
Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD. Identification of Nexinhibs, small-molecule inhibitors of neutrophil exocytosis and inflammation. Druggability of the small GTPase Rab27a. The Journal of Biological Chemistry. PMID 27702998 DOI: 10.1074/Jbc.M116.741884 |
0.345 |
|
| 2016 |
Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. Journal of the American Chemical Society. PMID 27689866 DOI: 10.1021/Jacs.6B07830 |
0.301 |
|
| 2016 |
Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J. Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. Mucosal Immunology. PMID 27049060 DOI: 10.1038/Mi.2016.35 |
0.411 |
|
| 2016 |
Scott FL, Clemons B, Brooks J, Brahmachary E, Powell R, Dedman H, Desale HG, Timony GA, Martinborough E, Rosen H, Roberts E, Boehm MF, Peach RJ. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. British Journal of Pharmacology. 173: 1778-92. PMID 26990079 DOI: 10.1111/Bph.13476 |
0.453 |
|
| 2016 |
Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787880 DOI: 10.1073/Pnas.1525356113 |
0.414 |
|
| 2015 |
Sanna MG, Vincent KP, Repetto E, Nhan N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Heller Brown J, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. Bitopic S1P3 Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Molecular Pharmacology. PMID 26494861 DOI: 10.1124/Mol.115.100222 |
0.366 |
|
| 2015 |
Blanc CA, Grist JJ, Rosen H, Sears-Kraxberger I, Steward O, Lane TE. Sphingosine-1-Phosphate Receptor Antagonism Enhances Proliferation and Migration of Engrafted Neural Progenitor Cells in a Model of Viral-Induced Demyelination. The American Journal of Pathology. 185: 2819-32. PMID 26435414 DOI: 10.1016/J.Ajpath.2015.06.009 |
0.401 |
|
| 2015 |
Niphakis MJ, Lum KM, Cognetta AB, Correia BE, Ichu TA, Olucha J, Brown SJ, Kundu S, Piscitelli F, Rosen H, Cravatt BF. A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 161: 1668-80. PMID 26091042 DOI: 10.1016/J.Cell.2015.05.045 |
0.308 |
|
| 2015 |
Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/Cb500893Q |
0.304 |
|
| 2015 |
Skerry C, Scanlon K, Rosen H, Carbonetti NH. Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology. The Journal of Infectious Diseases. 211: 1883-6. PMID 25538274 DOI: 10.1093/Infdis/Jiu823 |
0.375 |
|
| 2014 |
Gonzalez-Cabrera PJ, Brown S, Studer SM, Rosen H. S1P signaling: new therapies and opportunities. F1000prime Reports. 6: 109. PMID 25580263 DOI: 10.12703/P6-109 |
0.42 |
|
| 2014 |
Chang MR, Rosen H, Griffin PR. RORs in autoimmune disease. Current Topics in Microbiology and Immunology. 378: 171-82. PMID 24728598 DOI: 10.1007/978-3-319-05879-5_8 |
0.383 |
|
| 2014 |
Oldstone MB, Rosen H. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. Current Topics in Microbiology and Immunology. 378: 129-47. PMID 24728596 DOI: 10.1007/978-3-319-05879-5_6 |
0.308 |
|
| 2014 |
Rosen H, Germana Sanna M, Gonzalez-Cabrera PJ, Roberts E. The organization of the sphingosine 1-phosphate signaling system. Current Topics in Microbiology and Immunology. 378: 1-21. PMID 24728591 DOI: 10.1007/978-3-319-05879-5_1 |
0.421 |
|
| 2014 |
Walsh KB, Teijaro JR, Brock LG, Fremgen DM, Collins PL, Rosen H, Oldstone MB. Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. Journal of Virology. 88: 6281-93. PMID 24672024 DOI: 10.1128/Jvi.00464-14 |
0.355 |
|
| 2014 |
Teijaro JR, Walsh KB, Rice S, Rosen H, Oldstone MB. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America. 111: 3799-804. PMID 24572573 DOI: 10.1073/Pnas.1400593111 |
0.325 |
|
| 2014 |
Ohotski J, Rosen H, Bittman R, Pyne S, Pyne NJ. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. Cellular Signalling. 26: 1040-7. PMID 24486401 DOI: 10.1016/J.Cellsig.2014.01.023 |
0.405 |
|
| 2013 |
Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E. Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorganic & Medicinal Chemistry Letters. 23: 6346-9. PMID 24135724 DOI: 10.1016/J.Bmcl.2013.09.075 |
0.413 |
|
| 2013 |
Urbano M, Guerrero M, Rosen H, Roberts E. Modulators of the Sphingosine 1-phosphate receptor 1. Bioorganic & Medicinal Chemistry Letters. 23: 6377-89. PMID 24125884 DOI: 10.1016/J.Bmcl.2013.09.058 |
0.364 |
|
| 2013 |
Satsu H, Schaeffer MT, Guerrero M, Saldana A, Eberhart C, Hodder P, Cayanan C, Schürer S, Bhhatarai B, Roberts E, Rosen H, Brown SJ. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorganic & Medicinal Chemistry. 21: 5373-82. PMID 23849205 DOI: 10.1016/J.Bmc.2013.06.012 |
0.433 |
|
| 2013 |
Roberts E, Guerrero M, Urbano M, Rosen H. Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012). Expert Opinion On Therapeutic Patents. 23: 817-41. PMID 23541049 DOI: 10.1517/13543776.2013.783022 |
0.402 |
|
| 2013 |
Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. Plos One. 8: e58033. PMID 23533579 DOI: 10.1371/Journal.Pone.0058033 |
0.311 |
|
| 2013 |
Rosen H, Stevens RC, Hanson M, Roberts E, Oldstone MB. Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annual Review of Biochemistry. 82: 637-62. PMID 23527695 DOI: 10.1146/Annurev-Biochem-062411-130916 |
0.434 |
|
| 2013 |
Guerrero M, Urbano M, Schaeffer MT, Brown S, Rosen H, Roberts E. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 614-9. PMID 23287738 DOI: 10.1016/J.Bmcl.2012.12.030 |
0.305 |
|
| 2013 |
Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wüthrich K. The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nature Reviews. Drug Discovery. 12: 25-34. PMID 23237917 DOI: 10.1038/Nrd3859 |
0.315 |
|
| 2013 |
Hulleman JD, Brown SJ, Rosen H, Kelly JW. A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of Biomolecular Screening. 18: 647-58. PMID 23230284 DOI: 10.1177/1087057112469405 |
0.315 |
|
| 2013 |
Oldstone MB, Teijaro JR, Walsh KB, Rosen H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection. Virology. 435: 92-101. PMID 23217619 DOI: 10.1016/J.Virol.2012.09.039 |
0.373 |
|
| 2013 |
Cahalan SM, Gonzalez-Cabrera PJ, Nguyen N, Guerrero M, Cisar EA, Leaf NB, Brown SJ, Roberts E, Rosen H. Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist. Molecular Pharmacology. 83: 316-21. PMID 23204443 DOI: 10.1124/Mol.112.082958 |
0.416 |
|
| 2013 |
Olson A, Timony G, Hartung JP, Smith H, Peach RJ, Rosen H, Pan C, Brooks J, Boehm M, Gujrathi S. Sa1222 Results of a Safety and Tolerability Study of Rpc1063, a Novel Orally Administered Sphingosine-1-Phosphate Receptor 1 (S1p1r) Agonist, in Healthy Adult Volunteers Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)60828-8 |
0.322 |
|
| 2013 |
Brooks J, Peach RJ, Boehm M, Brahmachary E, Clemons B, Dedman H, Desale H, Gujrathi S, Huang L, Hartung JP, Martinborough E, Moorjani M, Powell R, Reinhart G, Scott FL, ... ... Rosen H, et al. Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers Gastroenterology. 144: S-234. DOI: 10.1016/S0016-5085(13)60827-6 |
0.359 |
|
| 2012 |
Urbano M, Guerrero M, Zhao J, Velaparthi S, Saldanha SA, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorganic & Medicinal Chemistry Letters. 22: 7135-41. PMID 23079522 DOI: 10.1016/J.Bmcl.2012.09.074 |
0.343 |
|
| 2012 |
Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Schürer SC, Rosen H. Novel selective allosteric and bitopic ligands for the S1P(3) receptor. Acs Chemical Biology. 7: 1975-83. PMID 22971058 DOI: 10.1021/Cb300392Z |
0.426 |
|
| 2012 |
Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/Ja303400U |
0.309 |
|
| 2012 |
Dillon MB, Bachovchin DA, Brown SJ, Finn MG, Rosen H, Cravatt BF, Mowen KA. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. Acs Chemical Biology. 7: 1198-204. PMID 22506763 DOI: 10.1021/Cb300024C |
0.32 |
|
| 2012 |
Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC. Crystal structure of a lipid G protein-coupled receptor. Science (New York, N.Y.). 335: 851-5. PMID 22344443 DOI: 10.1126/Science.1215904 |
0.422 |
|
| 2012 |
Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1Pâ‚„-R) agonists. Bioorganic & Medicinal Chemistry Letters. 22: 537-42. PMID 22119461 DOI: 10.1016/J.Bmcl.2011.10.096 |
0.399 |
|
| 2012 |
Gonzalez-Cabrera PJ, Cahalan SM, Nguyen N, Sarkisyan G, Leaf NB, Cameron MD, Kago T, Rosen H. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Molecular Pharmacology. 81: 166-74. PMID 22031473 DOI: 10.1124/Mol.111.076109 |
0.384 |
|
| 2012 |
Gonzalez-Cabrera PJ, Cahalan SM, Ferguson J, Rosen H. S1P Receptor Modulators in Cell Trafficking and Therapeutics Current Immunology Reviews. 8: 170-180. DOI: 10.2174/157339512800099710 |
0.433 |
|
| 2011 |
Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorganic & Medicinal Chemistry Letters. 21: 6739-45. PMID 21982495 DOI: 10.1016/J.Bmcl.2011.09.049 |
0.404 |
|
| 2011 |
Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell. 146: 980-91. PMID 21925319 DOI: 10.1016/J.Cell.2011.08.015 |
0.403 |
|
| 2011 |
Walsh KB, Teijaro JR, Rosen H, Oldstone MB. Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm. Immunologic Research. 51: 15-25. PMID 21901448 DOI: 10.1007/S12026-011-8240-Z |
0.312 |
|
| 2011 |
Urbano M, Guerrero M, Zhao J, Velaparthi S, Schaeffer MT, Brown S, Rosen H, Roberts E. SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1Pâ‚„) receptor. Bioorganic & Medicinal Chemistry Letters. 21: 5470-4. PMID 21783362 DOI: 10.1016/J.Bmcl.2011.06.132 |
0.45 |
|
| 2011 |
Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/Ja2036095 |
0.338 |
|
| 2011 |
Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Journal of Medicinal Chemistry. 54: 5229-36. PMID 21639134 DOI: 10.1021/Jm200502U |
0.326 |
|
| 2011 |
Guerrero M, Urbano M, Velaparthi S, Zhao J, Schaeffer MT, Brown S, Rosen H, Roberts E. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 3632-6. PMID 21570287 DOI: 10.1016/J.Bmcl.2011.04.097 |
0.426 |
|
| 2011 |
Cahalan SM, Gonzalez-Cabrera PJ, Sarkisyan G, Nguyen N, Schaeffer MT, Huang L, Yeager A, Clemons B, Scott F, Rosen H. Actions of a picomolar short-acting S1Pâ‚ agonist in S1Pâ‚-eGFP knock-in mice. Nature Chemical Biology. 7: 254-6. PMID 21445057 DOI: 10.1038/Nchembio.547 |
0.432 |
|
| 2011 |
Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/Pnas.1015248108 |
0.303 |
|
| 2011 |
Marsolais D, Yagi S, Kago T, Leaf N, Rosen H. Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs. Molecular Pharmacology. 79: 61-8. PMID 20935081 DOI: 10.1124/Mol.110.066811 |
0.42 |
|
| 2011 |
Urbano M, Guerrero M, Zhao J, Velaparthi S, Schaeffer M, Brown S, Rosen H, Roberts E. ChemInform Abstract: SAR Analysis of Innovative Selective Small Molecule Antagonists of Sphingosine-1-phosphate 4 (S1P4) Receptor. Cheminform. 43: no-no. DOI: 10.1002/CHIN.201203198 |
0.305 |
|
| 2010 |
Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chemical Communications (Cambridge, England). 46: 7175-7. PMID 20740228 DOI: 10.1039/C0Cc02634D |
0.309 |
|
| 2010 |
Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. Acs Chemical Biology. 5: 981-93. PMID 20715845 DOI: 10.1021/Cb100219N |
0.343 |
|
| 2010 |
Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). Bioorganic & Medicinal Chemistry Letters. 20: 2254-8. PMID 20207142 DOI: 10.1016/J.Bmcl.2010.02.011 |
0.311 |
|
| 2010 |
Walsh KB, Marsolais D, Welch MJ, Rosen H, Oldstone MB. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. Virology. 397: 260-9. PMID 19962171 DOI: 10.1016/J.Virol.2009.08.043 |
0.305 |
|
| 2009 |
Cahalan S, Rosen H. S1P1 signaling just keeps going and going and going... Nature Chemical Biology. 5: 377-8. PMID 19448604 DOI: 10.1038/Nchembio0609-377 |
0.398 |
|
| 2009 |
Marsolais D, Rosen H. Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. Nature Reviews. Drug Discovery. 8: 297-307. PMID 19300460 DOI: 10.1038/Nrd2356 |
0.38 |
|
| 2009 |
Fazilleau N, McHeyzer-Williams LJ, Rosen H, McHeyzer-Williams MG. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nature Immunology. 10: 375-84. PMID 19252493 DOI: 10.1038/Ni.1704 |
0.308 |
|
| 2009 |
Rosen H, Gonzalez-Cabrera PJ, Sanna MG, Brown S. Sphingosine 1-phosphate receptor signaling. Annual Review of Biochemistry. 78: 743-68. PMID 19231986 DOI: 10.1146/Annurev.Biochem.78.072407.103733 |
0.375 |
|
| 2009 |
Marsolais D, Hahm B, Walsh KB, Edelmann KH, McGavern D, Hatta Y, Kawaoka Y, Rosen H, Oldstone MB. A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America. 106: 1560-5. PMID 19164548 DOI: 10.1073/Pnas.0812689106 |
0.312 |
|
| 2009 |
Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 113: 2859-66. PMID 19141861 DOI: 10.1182/Blood-2008-12-192385 |
0.42 |
|
| 2009 |
Goldsmith M, Avni D, Levy-Rimler G, Mashiach R, Ernst O, Levi M, Webb B, Meijler MM, Gray NS, Rosen H, Zor T. A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages. Immunology. 127: 103-15. PMID 18793216 DOI: 10.1111/J.1365-2567.2008.02928.X |
0.312 |
|
| 2008 |
Gonzalez-Cabrera PJ, Jo E, Sanna MG, Brown S, Leaf N, Marsolais D, Schaeffer MT, Chapman J, Cameron M, Guerrero M, Roberts E, Rosen H. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Molecular Pharmacology. 74: 1308-18. PMID 18708635 DOI: 10.1124/Mol.108.049783 |
0.431 |
|
| 2008 |
Rosen H, Gonzalez-Cabrera P, Marsolais D, Cahalan S, Don AS, Sanna MG. Modulating tone: the overture of S1P receptor immunotherapeutics. Immunological Reviews. 223: 221-35. PMID 18613839 DOI: 10.1111/J.1600-065X.2008.00645.X |
0.437 |
|
| 2008 |
Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer M, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H. Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening. Acs Chemical Biology. 3: 486-498. PMID 18590333 DOI: 10.1021/Cb800051M |
0.458 |
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| 2008 |
Marsolais D, Hahm B, Edelmann KH, Walsh KB, Guerrero M, Hatta Y, Kawaoka Y, Roberts E, Oldstone MB, Rosen H. Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Molecular Pharmacology. 74: 896-903. PMID 18577684 DOI: 10.1124/Mol.108.048769 |
0.391 |
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| 2008 |
Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature. 452: 654-8. PMID 18305483 DOI: 10.1038/Nature06663 |
0.411 |
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| 2007 |
Tsukada YT, Sanna MG, Rosen H, Gottlieb RA. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. Journal of Cardiovascular Pharmacology. 50: 660-9. PMID 18091583 DOI: 10.1097/Fjc.0B013E318157A5Fe |
0.342 |
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| 2007 |
Lee H, Brown SJ, Rosen H, Tobias PS. Application of β-Lactamase Enzyme Complementation to the High-Throughput Screening of Toll-Like Receptor Signaling Inhibitors Molecular Pharmacology. 72: 868-875. PMID 17615244 DOI: 10.1124/Mol.107.038349 |
0.332 |
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| 2007 |
Rosen H, Sanna MG, Cahalan SM, Gonzalez-Cabrera PJ. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends in Immunology. 28: 102-107. PMID 17276731 DOI: 10.1016/J.It.2007.01.007 |
0.442 |
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| 2007 |
Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. The Journal of Biological Chemistry. 282: 7254-64. PMID 17218309 DOI: 10.1074/Jbc.M610581200 |
0.441 |
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| 2006 |
Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature Chemical Biology. 2: 434-41. PMID 16829954 DOI: 10.1038/Nchembio804 |
0.427 |
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| 2006 |
Chun J, Rosen H. Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Current Pharmaceutical Design. 12: 161-71. PMID 16454733 DOI: 10.2174/138161206775193109 |
0.435 |
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| 2006 |
Alfonso C, McHeyzer-Williams MG, Rosen H. CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors. European Journal of Immunology. 36: 149-59. PMID 16342326 DOI: 10.1002/Eji.200535127 |
0.405 |
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| 2005 |
Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nature Immunology. 6: 1228-35. PMID 16273098 DOI: 10.1038/Ni1269 |
0.429 |
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| 2005 |
Li Z, Chen W, Hale JJ, Lynch CL, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Parent SA, Bergstrom J, Card D, Forrest M, ... ... Rosen H, et al. Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. Journal of Medicinal Chemistry. 48: 6169-73. PMID 16190743 DOI: 10.1021/jm0503244 |
0.314 |
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| 2005 |
Rosen H. Chemical approaches to the lysophospholipid receptors. Prostaglandins & Other Lipid Mediators. 77: 179-184. PMID 16099402 DOI: 10.1016/J.Prostaglandins.2004.09.011 |
0.37 |
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| 2005 |
Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network Nature Reviews Immunology. 5: 560-570. PMID 15999095 DOI: 10.1038/Nri1650 |
0.451 |
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| 2005 |
Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL, Rosen H. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chemistry & Biology. 12: 703-15. PMID 15975516 DOI: 10.1016/J.Chembiol.2005.04.019 |
0.434 |
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| 2005 |
Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H. S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF Proceedings of the National Academy of Sciences of the United States of America. 102: 9270-9275. PMID 15968000 DOI: 10.1073/Pnas.0501997102 |
0.378 |
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| 2005 |
Gong Q, Ou Q, Ye S, Lee WP, Cornelius J, Diehl L, Lin WY, Hu Z, Lu Y, Chen Y, Wu Y, Meng YG, Gribling P, Lin Z, Nguyen K, ... ... Rosen H, et al. Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. Journal of Immunology (Baltimore, Md. : 1950). 174: 817-26. PMID 15634903 DOI: 10.4049/Jimmunol.174.2.817 |
0.307 |
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| 2004 |
Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, ... ... Rosen H, et al. A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. Journal of Medicinal Chemistry. 47: 6662-5. PMID 15615513 DOI: 10.1021/Jm0492507 |
0.426 |
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| 2004 |
Goetzl EJ, Rosen H. Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. Journal of Clinical Investigation. 114: 1531-1537. PMID 15578083 DOI: 10.1172/Jci23704 |
0.386 |
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| 2004 |
Yan L, Hale JJ, Lynch CL, Budhu R, Gentry A, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Rosen H, et al. Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorganic & Medicinal Chemistry Letters. 14: 4861-6. PMID 15341940 DOI: 10.1016/J.Bmcl.2004.07.049 |
0.396 |
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| 2004 |
Hale JJ, Doherty G, Toth L, Mills SG, Hajdu R, Keohane CA, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Forrest M, Sun SY, West S, ... ... Rosen H, et al. Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 3501-5. PMID 15177461 DOI: 10.1016/J.Bmcl.2004.04.070 |
0.403 |
|
| 2004 |
Hale JJ, Doherty G, Toth L, Li Z, Mills SG, Hajdu R, Ann Keohane C, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Rosen H, Mandala S. The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 3495-9. PMID 15177460 DOI: 10.1016/J.Bmcl.2004.04.069 |
0.389 |
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| 2004 |
Hale JJ, Neway W, Mills SG, Hajdu R, Ann Keohane C, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Koo GC, Koprak SL, Jackson JJ, Rosen H, et al. Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorganic & Medicinal Chemistry Letters. 14: 3351-5. PMID 15149705 DOI: 10.1016/J.Bmcl.2004.02.106 |
0.445 |
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| 2004 |
Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J, Mills S, Nomura N, Rosen H, Rosenbach M, Shei GJ, et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 309: 758-68. PMID 14747617 DOI: 10.1124/Jpet.103.062828 |
0.459 |
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| 2004 |
Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. The Journal of Biological Chemistry. 279: 13839-48. PMID 14732717 DOI: 10.1074/Jbc.M311743200 |
0.643 |
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| 2003 |
Ferrer M, Kolodin GD, Zuck P, Peltier R, Berry K, Mandala SM, Rosen H, Ota H, Ozaki S, Inglese J, Strulovici B. A fully automated [35S]GTPgammaS scintillation proximity assay for the high-throughput screening of Gi-linked G protein-coupled receptors. Assay and Drug Development Technologies. 1: 261-73. PMID 15090191 DOI: 10.1089/15406580360545071 |
0.335 |
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| 2003 |
Rosen H, Sanna G, Alfonso C. Egress: a receptor-regulated step in lymphocyte trafficking. Immunological Reviews. 195: 160-177. PMID 12969317 DOI: 10.1034/J.1600-065X.2003.00068.X |
0.39 |
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| 2003 |
Rosen H, Alfonso C, Surh CD, McHeyzer-Williams MG. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proceedings of the National Academy of Sciences of the United States of America. 100: 10907-12. PMID 12954982 DOI: 10.1073/Pnas.1832725100 |
0.382 |
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| 2003 |
Rosen H, Liao J. Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Current Opinion in Chemical Biology. 7: 461-8. PMID 12941420 DOI: 10.1016/S1367-5931(03)00085-1 |
0.616 |
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| 2003 |
Xie JH, Nomura N, Koprak SL, Quackenbush EJ, Forrest MJ, Rosen H. Sphingosine-1-phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells Journal of Immunology. 170: 3662-3670. PMID 12646631 DOI: 10.4049/Jimmunol.170.7.3662 |
0.357 |
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| 2002 |
Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, ... Rosen H, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (New York, N.Y.). 296: 346-9. PMID 11923495 DOI: 10.1126/Science.1070238 |
0.437 |
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| 1995 |
Gordon EJ, Myers KJ, Dougherty JP, Rosen H, Ron Y. Bothanti-CD11a(LFA-l) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis Journal of Neuroimmunology. 62: 153-160. PMID 7499503 DOI: 10.1016/0165-5728(95)00120-2 |
0.313 |
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| 1994 |
Siciliano SJ, Rollins TE, DeMartino J, Konteatis Z, Malkowitz L, Van Riper G, Bondy S, Rosen H, Springer MS. Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 1214-8. PMID 8108389 DOI: 10.1073/Pnas.91.4.1214 |
0.362 |
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| 1993 |
Cervia JS, Rosen H, Murray HW. Effector role of blood monocytes in experimental visceral leishmaniasis. Infection and Immunity. 61: 1330-1333. PMID 8454335 DOI: 10.1128/Iai.61.4.1330-1333.1993 |
0.309 |
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| 1993 |
Riper GV, Siciliano S, Fischer PA, Meurer R, Springer MS, Rosen H. Characterization and species distribution of high affinity GTP-coupled receptors for human rantes and monocyte chemoattractant protein 1. Journal of Experimental Medicine. 177: 851-856. PMID 7679712 DOI: 10.1084/Jem.177.3.851 |
0.389 |
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| 1993 |
Meurer R, Van Riper G, Feeney W, Cunningham P, Hora D, Springer MS, MacIntyre DE, Rosen H. Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8. The Journal of Experimental Medicine. 178: 1913-21. PMID 7504053 DOI: 10.1084/Jem.178.6.1913 |
0.309 |
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| 1991 |
Grau GE, Pointaire P, Piguet PF, Vesin C, Rosen H, Stamenkovic I, Takei F, Vassalli P. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. European Journal of Immunology. 21: 2265-7. PMID 1679717 DOI: 10.1002/Eji.1830210939 |
0.318 |
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| 1990 |
Rosen H, Gordon S. Adoptive transfer of fluorescence-labeled cells shows that resident peritonealmacrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse European Journal of Immunology. 20: 1251-1258. PMID 2369918 DOI: 10.1002/Eji.1830200609 |
0.31 |
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| 1990 |
Hutchings P, Rosen H, O'Reilly L, Simpson E, Gordon S, Cooke A. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Nature. 348: 639-642. PMID 2250718 DOI: 10.1038/348639A0 |
0.326 |
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| 1990 |
Rosen H, Gordon S. The role of the type 3 complement receptor in the induced recruitment of myelomonocytic cells to inflammatory sites in the mouse. American Journal of Respiratory Cell and Molecular Biology. 3: 3-10. PMID 2141991 DOI: 10.1165/Ajrcmb/3.1.3 |
0.368 |
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| 1990 |
Rosen H, Law SKA. The leukocyte cell surface receptor(s) for the iC3b product of complement. Current Topics in Microbiology and Immunology. 153: 99-122. PMID 2137074 DOI: 10.1007/978-3-642-74977-3_6 |
0.333 |
|
| 1989 |
Rosen H, Milon G, Gordon S. Antibody to the murine type 3 complement receptor inhibits T lymphocyte-dependent recruitment of myelomonocytic cells in vivo. Journal of Experimental Medicine. 169: 535-548. PMID 2521356 DOI: 10.1084/Jem.169.2.535 |
0.342 |
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| 1989 |
Rosen H, Gordon S, North RJ. Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells. Journal of Experimental Medicine. 170: 27-37. PMID 2501445 DOI: 10.1084/Jem.170.1.27 |
0.31 |
|
| 1987 |
Rosen H, Gordon S. Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. Journal of Experimental Medicine. 166: 1685-1701. PMID 2445894 DOI: 10.1084/Jem.166.6.1685 |
0.341 |
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