William Clemons, Ph.D. - Publications

Affiliations: 
Chemistry and Chemical Engineering California Institute of Technology, Pasadena, CA 
Area:
X-ray crystallography
Website:
https://www.cce.caltech.edu/content/william-m-clemons

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Mitachi K, Mingle D, Effah W, Sánchez-Ruiz A, Hevener KE, Narayanan R, Clemons WM, Sarabia F, Kurosu M. Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor. Angewandte Chemie (International Ed. in English). e202203225. PMID 35594368 DOI: 10.1002/anie.202203225  0.472
2021 Fry MY, Saladi SM, Cunha A, Clemons WM. Sequence-based features that are determinant for tail-anchored membrane protein sorting in eukaryotes. Traffic (Copenhagen, Denmark). PMID 34288289 DOI: 10.1111/tra.12809  0.818
2021 Fry MY, Saladi SM, Clemons WM. The STI1-domain is a flexible alpha-helical fold with a hydrophobic groove. Protein Science : a Publication of the Protein Society. PMID 33620121 DOI: 10.1002/pro.4049  0.795
2021 Lin KF, Fry MY, Saladi SM, Clemons WM. Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2. The Journal of Biological Chemistry. 100441. PMID 33610544 DOI: 10.1016/j.jbc.2021.100441  0.824
2020 Mitachi K, Kansal RG, Hevener KE, Gillman CD, Hussain SM, Yun HG, Miranda-Carboni GA, Glazer ES, Clemons WM, Kurosu M. DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors. Journal of Medicinal Chemistry. PMID 32886511 DOI: 10.1021/Acs.Jmedchem.0C00545  0.481
2019 Mitachi K, Yun HG, Gillman CD, Skorupinska-Tudek K, Swiezewska E, Clemons WM, Kurosu M. Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays. Acs Infectious Diseases. PMID 31769280 DOI: 10.1021/Acsinfecdis.9B00242  0.527
2019 Mitachi K, Kurosu SM, Gillman CD, Yun HG, Clemons WM, Kurosu M. A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies. Methodsx. 6: 2305-2321. PMID 31667130 DOI: 10.1016/J.Mex.2019.09.031  0.522
2019 Mitachi K, Kurosu SM, Eslamimehr S, Lemieux MR, Ishizaki Y, Clemons WM, Kurosu M. Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate. Organic Letters. 21: 876-879. PMID 30698984 DOI: 10.1021/Acs.Orglett.8B03716  0.49
2018 Mitachi K, Yun HG, Kurosu SM, Eslamimehr S, Lemieux MR, Klaić L, Clemons WM, Kurosu M. Novel FR-900493 Analogues That Inhibit the Outgrowth ofSpores. Acs Omega. 3: 1726-1739. PMID 29503973 DOI: 10.1021/acsomega.7b01740  0.748
2018 Saladi SM, Javed N, Müller A, Clemons WM. A statistical model for improved membrane protein expression using sequence-derived features. The Journal of Biological Chemistry. PMID 29378850 DOI: 10.1074/Jbc.Ra117.001052  0.802
2018 Fry MY, Clemons WM. Complexity in targeting membrane proteins. Science (New York, N.Y.). 359: 390-391. PMID 29371455 DOI: 10.1126/Science.Aar5992  0.834
2017 Mock JY, Xu Y, Ye Y, Clemons WM. Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042515 DOI: 10.1073/Pnas.1702940114  0.743
2017 Niesen MJM, Marshall SS, Miller TF, Clemons WM. Improving membrane protein expression by optimizing integration efficiency. The Journal of Biological Chemistry. PMID 28918393 DOI: 10.1074/Jbc.M117.813469  0.599
2017 Saladi S, Chu AE, Clemons WM. Statistical Models Robustly Predict Membrane Protein Expression in E. Coli Biophysical Journal. 112: 356a. DOI: 10.1016/J.Bpj.2016.11.1929  0.796
2017 Schulte SJ, Saladi S, Clemons WM. Predicting Membrane Protein Expression in Yeast from Sequence-Derived Features Biophysical Journal. 112: 355a-356a. DOI: 10.1016/J.Bpj.2016.11.1928  0.792
2017 Chu AE, Saladi SM, Bradbury N, Clemons WM. Towards a Universal Characterization of the Membrane Protein Expression Landscape Biophysical Journal. 112: 188a. DOI: 10.1016/J.Bpj.2016.11.1046  0.79
2016 Marshall SS, Niesen MJ, Müller A, Tiemann K, Saladi SM, Galimidi RP, Zhang B, Clemons WM, Miller TF. A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency. Cell Reports. PMID 27524616 DOI: 10.1016/J.Celrep.2016.07.042  0.795
2016 Lin K, Clemons WM. Promiscuous Binding of Membrane Proteins on Flexible Co-Chaperones, Yeast Sgt2 and Human SGTA Biophysical Journal. 110: 560a. DOI: 10.1016/J.Bpj.2015.11.2994  0.832
2016 Saladi SM, Javed N, Müller A, Clemons WM. A Machine Learning Approach to Heterologous Membrane Protein Overexpression Biophysical Journal. 110: 39a. DOI: 10.1016/J.Bpj.2015.11.278  0.817
2015 Gristick HB, Rome ME, Chartron JW, Rao M, Hess S, Shan SO, Clemons WM. Mechanism of assembly of a substrate-transfer complex during tail-anchored protein targeting. The Journal of Biological Chemistry. PMID 26451041 DOI: 10.1074/Jbc.M115.677328  0.827
2015 Mitachi K, Siricilla S, Klaic L, Clemons WM, Kurosu M. Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes. Tetrahedron Letters. 56: 3441-3446. PMID 26190869 DOI: 10.1016/J.Tetlet.2015.01.044  0.77
2015 Mock JY, Clemons WM. Capturing the signal. Elife. 4. PMID 26158505 DOI: 10.7554/Elife.09315  0.664
2015 Jang KS, Nani RR, Kalli A, Levin S, Müller A, Hess S, Reisman SE, Clemons WM. A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides. Analytical and Bioanalytical Chemistry. PMID 26100547 DOI: 10.1007/S00216-015-8798-8  0.731
2015 Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 106-11. PMID 25535373 DOI: 10.1073/Pnas.1402745112  0.823
2015 Mitachi K, Siricilla S, Klai? L, Clemons WM, Kurosu M. Chemoenzymatic syntheses of water-soluble lipid i fluorescent probes This Letter is dedicated to the memory of Professor Harry H. Wasserman, an inspirational scientist Tetrahedron Letters. 56: 3441-3446. DOI: 10.1016/j.tetlet.2015.01.044  0.464
2014 Müller A, Beeby M, McDowall AW, Chow J, Jensen GJ, Clemons WM. Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni. Microbiologyopen. 3: 702-10. PMID 25065852 DOI: 10.1002/mbo3.200  0.508
2014 Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM. Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4. Nature Structural & Molecular Biology. 21: 437-42. PMID 24727835 DOI: 10.1038/Nsmb.2813  0.832
2014 Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM, Ye Y. USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. Elife. 3: e01369. PMID 24424410 DOI: 10.7554/eLife.01369  0.491
2014 Jang KS, Sweredoski MJ, Graham RL, Hess S, Clemons WM. Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni. Journal of Proteomics. 98: 90-8. PMID 24382552 DOI: 10.1016/j.jprot.2013.12.014  0.706
2014 Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM, Ye Y. USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation Elife. 2014. DOI: 10.7554/eLife.01369.001  0.374
2013 Rome ME, Rao M, Clemons WM, Shan SO. Precise timing of ATPase activation drives targeting of tail-anchored proteins Proceedings of the National Academy of Sciences of the United States of America. 110: 7666-7671. PMID 23610396 DOI: 10.1073/Pnas.1222054110  0.428
2013 Ramasamy S, Abrol R, Suloway CJ, Clemons WM. The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. Structure (London, England : 1993). 21: 777-88. PMID 23583035 DOI: 10.1016/J.Str.2013.03.004  0.829
2012 Chartron JW, VanderVelde DG, Clemons WM. Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. Cell Reports. 2: 1620-32. PMID 23142665 DOI: 10.1016/j.celrep.2012.10.010  0.824
2012 Tanaka S, Clemons WM. Minimal requirements for inhibition of MraY by lysis protein E from bacteriophage ΦX174 Molecular Microbiology. 85: 975-985. PMID 22742425 DOI: 10.1111/J.1365-2958.2012.08153.X  0.572
2012 Chartron JW, Clemons WM, Suloway CJ. The complex process of GETting tail-anchored membrane proteins to the ER. Current Opinion in Structural Biology. 22: 217-24. PMID 22444563 DOI: 10.1016/j.sbi.2012.03.001  0.848
2012 Chartron JW, VanderVelde DG, Rao M, Clemons WM. Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex. The Journal of Biological Chemistry. 287: 8310-7. PMID 22262836 DOI: 10.1074/Jbc.M111.333252  0.803
2012 Suloway CJ, Rome ME, Clemons WM. Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue. The Embo Journal. 31: 707-19. PMID 22124326 DOI: 10.1038/Emboj.2011.433  0.827
2011 Chartron JW, Gonzalez GM, Clemons WM. A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex. The Journal of Biological Chemistry. 286: 34325-34. PMID 21832041 DOI: 10.1074/jbc.M111.277798  0.805
2010 Chartron JW, Suloway CJ, Zaslaver M, Clemons WM. Structural characterization of the Get4/Get5 complex and its interaction with Get3. Proceedings of the National Academy of Sciences of the United States of America. 107: 12127-32. PMID 20554915 DOI: 10.1073/pnas.1006036107  0.822
2009 Suloway CJ, Chartron JW, Zaslaver M, Clemons WM. Model for eukaryotic tail-anchored protein binding based on the structure of Get3. Proceedings of the National Academy of Sciences of the United States of America. 106: 14849-54. PMID 19706470 DOI: 10.1073/pnas.0907522106  0.836
2009 Ramasamy SK, Clemons WM. Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65: 746-750. PMID 19652330 DOI: 10.1107/S1744309109023811  0.727
2007 Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Molecular Cell. 28: 1083-92. PMID 18158904 DOI: 10.1016/J.Molcel.2007.10.034  0.773
2005 Smith MA, Clemons WM, DeMars CJ, Flower AM. Modeling the effects of prl mutations on the Escherichia coli SecY complex Journal of Bacteriology. 187: 6454-6465. PMID 16159779 DOI: 10.1128/JB.187.18.6454-6465.2005  0.334
2005 Cannon KS, Or E, Clemons WM, Shibata Y, Rapoport TA. Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. The Journal of Cell Biology. 169: 219-25. PMID 15851514 DOI: 10.1083/Jcb.200412019  0.672
2004 Clemons WM, Ménétret JF, Akey CW, Rapoport TA. Structural insight into the protein translocation channel. Current Opinion in Structural Biology. 14: 390-6. PMID 15313231 DOI: 10.1016/J.Sbi.2004.07.006  0.621
2004 Osborne AR, Clemons WM, Rapoport TA. A large conformational change of the translocation ATPase SecA. Proceedings of the National Academy of Sciences of the United States of America. 101: 10937-42. PMID 15256599 DOI: 10.1073/Pnas.0401742101  0.732
2004 van den Berg B, Black PN, Clemons WM, Rapoport TA. Crystal structure of the long-chain fatty acid transporter FadL. Science (New York, N.Y.). 304: 1506-9. PMID 15178802 DOI: 10.1126/Science.1097524  0.503
2004 Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA. X-ray structure of a protein-conducting channel. Nature. 427: 36-44. PMID 14661030 DOI: 10.1038/Nature02218  0.766
2003 Brodersen DE, Clemons WM, Carter AP, Wimberly BT, Ramakrishnan V. Phasing the 30S ribosomal subunit structure. Acta Crystallographica. Section D, Biological Crystallography. 59: 2044-50. PMID 14573961 DOI: 10.1107/S0907444903017669  0.507
2002 Brodersen DE, Clemons WM, Carter AP, Wimberly BT, Ramakrishnan V. Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. Journal of Molecular Biology. 316: 725-68. PMID 11866529 DOI: 10.1006/jmbi.2001.5359  0.548
2001 Brodersen DE, Carter AP, Clemons WM, Morgan-Warren RJ, Murphy FV, Ogle JM, Tarry MJ, Wimberly BT, Ramakrishnan V. Atomic structures of the 30S subunit and its complexes with ligands and antibiotics. Cold Spring Harbor Symposia On Quantitative Biology. 66: 17-32. PMID 12762005  0.463
2001 Clemons WM, Brodersen DE, McCutcheon JP, May JL, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination. Journal of Molecular Biology. 310: 827-43. PMID 11453691 DOI: 10.1006/jmbi.2001.4778  0.495
2001 Ogle JM, Brodersen DE, Clemons WM, Tarry MJ, Carter AP, Ramakrishnan V. Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science (New York, N.Y.). 292: 897-902. PMID 11340196 DOI: 10.1126/science.1060612  0.473
2001 Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V. Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science (New York, N.Y.). 291: 498-501. PMID 11228145 DOI: 10.1126/science.1057766  0.542
2000 Brodersen DE, Clemons WM, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 103: 1143-54. PMID 11163189 DOI: 10.1016/S0092-8674(00)00216-6  0.507
2000 Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 407: 340-8. PMID 11014183 DOI: 10.1038/35030019  0.521
2000 Wimberly BT, Brodersen DE, Clemons WM, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V. Structure of the 30S ribosomal subunit. Nature. 407: 327-39. PMID 11014182 DOI: 10.1038/35030006  0.602
2000 Allard P, Rak AV, Wimberly BT, Clemons WM, Kalinin A, Helgstrand M, Garber MB, Ramakrishnan V, Härd T. Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit. Structure (London, England : 1993). 8: 875-82. PMID 10997906 DOI: 10.1016/S0969-2126(00)00177-5  0.529
1999 Clemons WM, Gowda K, Black SD, Zwieb C, Ramakrishnan V. Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding. Journal of Molecular Biology. 292: 697-705. PMID 10497032 DOI: 10.1006/jmbi.1999.3090  0.612
1999 Clemons WM, May JL, Wimberly BT, McCutcheon JP, Capel MS, Ramakrishnan V. Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution. Nature. 400: 833-40. PMID 10476960 DOI: 10.1038/23631  0.517
1999 Gowda K, Clemons WM, Zwieb C, Black SD. Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein Protein Science. 8: 1144-1151. PMID 10338025  0.383
1999 McCutcheon JP, Agrawal RK, Philips SM, Grassucci RA, Gerchman SE, Clemons WM, Ramakrishnan V, Frank J. Location of translational initiation factor IF3 on the small ribosomal subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 4301-6. PMID 10200257 DOI: 10.1073/Pnas.96.8.4301  0.516
1998 Clemons WM, Davies C, White SW, Ramakrishnan V. Conformational variability of the N-terminal helix in the structure of ribosomal protein S15. Structure (London, England : 1993). 6: 429-38. PMID 9562554  0.563
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