Laurent K. Verkoczy, Ph.D. - Publications

Affiliations: 
2000 University of Toronto, Toronto, ON, Canada 
Area:
Immunology, Molecular Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Caniels TG, Medina-Ramírez M, Zhang J, Sarkar A, Kumar S, LaBranche A, Derking R, Allen JD, Snitselaar JL, Capella-Pujol J, Sánchez IDM, Yasmeen A, Diaz M, Aldon Y, Bijl TPL, ... ... Verkoczy L, et al. Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell Reports. Medicine. 101003. PMID 37044090 DOI: 10.1016/j.xcrm.2023.101003  0.381
2023 Bibollet-Ruche F, Russell RM, Ding W, Liu W, Li Y, Wagh K, Wrapp D, Habib R, Skelly AN, Roark RS, Sherrill-Mix S, Wang S, Rando J, Lindemuth E, Cruickshank K, ... ... Verkoczy L, et al. A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies. Mbio. e0337022. PMID 36629414 DOI: 10.1128/mbio.03370-22  0.404
2022 Li X, Liao D, Li Z, Li J, Diaz M, Verkoczy L, Gao F. Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies. Frontiers in Immunology. 13: 977630. PMID 36479128 DOI: 10.3389/fimmu.2022.977630  0.319
2022 Hossain MA, Anasti K, Watts B, Cronin K, Derking R, Groschel B, Kane AP, Edwards RJ, Easterhoff D, Zhang J, Rountree W, Ortiz Y, Saunders K, Schief WR, Sanders RW, ... Verkoczy L, et al. B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates. Cell Reports. 39: 111021. PMID 35767950 DOI: 10.1016/j.celrep.2022.111021  0.397
2021 Crooks ET, Almanza F, D'Addabbo A, Duggan E, Zhang J, Wagh K, Mou H, Allen JD, Thomas A, Osawa K, Korber BT, Tsybovsky Y, Cale E, Nolan J, Crispin M, ... Verkoczy LK, et al. Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens. Plos Pathogens. 17: e1009807. PMID 34679128 DOI: 10.1371/journal.ppat.1009807  0.324
2020 Bradley T, Kuraoka M, Yeh CH, Tian M, Chen H, Cain DW, Chen X, Cheng C, Ellebedy AH, Parks R, Barr M, Sutherland LL, Scearce RM, Bowman CM, Bouton-Verville H, ... ... Verkoczy L, et al. Immune checkpoint modulation enhances HIV-1 antibody induction. Nature Communications. 11: 948. PMID 32075963 DOI: 10.1038/S41467-020-14670-W  0.526
2019 Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, ... ... Verkoczy L, et al. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science (New York, N.Y.). 366. PMID 31806786 DOI: 10.1126/Science.Aay7199  0.466
2019 Finney J, Yang G, Kuraoka M, Song S, Nojima T, Verkoczy L, Kitamura D, Haynes BF, Kelsoe G. Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5. Journal of Immunology (Baltimore, Md. : 1950). PMID 31732530 DOI: 10.4049/Jimmunol.1900069  0.533
2019 Andrabi R, Pallesen J, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, ... ... Verkoczy L, et al. The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell Reports. 27: 2426-2441.e6. PMID 31116986 DOI: 10.1016/J.Celrep.2019.04.082  0.461
2017 Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, et al. Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models. Cell Reports. 21: 3681-3690. PMID 29281818 DOI: 10.1016/J.Celrep.2017.12.028  0.48
2017 Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, ... ... Verkoczy L, et al. Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nature Communications. 8: 1732. PMID 29170366 DOI: 10.1038/S41467-017-01336-3  0.513
2017 Verkoczy L. Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem. Advances in Immunology. 134: 235-352. PMID 28413022 DOI: 10.1016/Bs.Ai.2017.01.004  0.454
2017 Kuraoka M, Snowden PB, Nojima T, Verkoczy L, Haynes BF, Kitamura D, Kelsoe G. BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. Cell Reports. 18: 1627-1635. PMID 28199836 DOI: 10.1016/J.Celrep.2017.01.050  0.446
2017 Verkoczy L, Alt FW, Tian M. Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. Immunological Reviews. 275: 89-107. PMID 28133799 DOI: 10.1111/Imr.12505  0.453
2016 Moody MA, Pedroza-Pacheco I, Vandergrift NA, Chui C, Lloyd KE, Parks R, Soderberg KA, Ogbe AT, Cohen MS, Liao HX, Gao F, McMichael AJ, Montefiori DC, Verkoczy L, Kelsoe G, et al. Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies. Science Immunology. 1: aag0851. PMID 28783677 DOI: 10.1126/Sciimmunol.Aag0851  0.441
2016 Wiehe K, Nicely NI, Lockwood B, Kuraoka M, Anasti K, Arora S, Bowman CM, Stolarchuk C, Parks R, Lloyd KE, Xia SM, Duffy R, Shen X, Kyratsous CA, Macdonald LE, ... ... Verkoczy L, et al. Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 28011932 DOI: 10.4049/Jimmunol.1601640  0.438
2016 Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, ... ... Verkoczy L, et al. HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. Journal of Immunology (Baltimore, Md. : 1950). PMID 27849170 DOI: 10.4049/Jimmunol.1601484  0.428
2016 Zhang R, Verkoczy L, Wiehe K, Munir Alam S, Nicely NI, Santra S, Bradley T, Pemble CW, Zhang J, Gao F, Montefiori DC, Bouton-Verville H, Kelsoe G, Larimore K, Greenberg PD, et al. Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Science Translational Medicine. 8: 336ra62. PMID 27122615 DOI: 10.1126/Scitranslmed.Aaf0618  0.496
2015 Wang Y, Kapoor P, Parks R, Silva-Sanchez A, Alam SM, Verkoczy L, Liao HX, Zhuang Y, Burrows P, Levinson M, Elgavish A, Cui X, Haynes BF, Schroeder H. HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. Immunogenetics. PMID 26687685 DOI: 10.1007/S00251-015-0890-X  0.443
2014 Haynes BF, Moody MA, Alam M, Bonsignori M, Verkoczy L, Ferrari G, Gao F, Tomaras GD, Liao HX, Kelsoe G. Progress in HIV-1 vaccine development. The Journal of Allergy and Clinical Immunology. 134: 3-10; quiz 11. PMID 25117798 DOI: 10.1016/J.Jaci.2014.04.025  0.44
2014 Kelsoe G, Verkoczy L, Haynes BF. Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines. 2: 1-14. PMID 24932410 DOI: 10.3390/Vaccines2010001  0.476
2014 Haynes BF, Verkoczy L, Kelsoe G. Redemption of autoreactive B cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 9022-3. PMID 24920593 DOI: 10.1073/Pnas.1407877111  0.492
2014 Verkoczy L, Kelsoe G, Haynes BF. HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development. Plos Pathogens. 10: e1004073. PMID 24853821 DOI: 10.1371/Journal.Ppat.1004073  0.461
2014 Haynes BF, Verkoczy L. AIDS/HIV. Host controls of HIV neutralizing antibodies. Science (New York, N.Y.). 344: 588-9. PMID 24812389 DOI: 10.1126/Science.1254990  0.536
2014 Verkoczy L, Diaz M. Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination. Current Opinion in Hiv and Aids. 9: 224-34. PMID 24714565 DOI: 10.1097/Coh.0000000000000049  0.432
2014 Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, ... ... Verkoczy L, et al. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. The Journal of Clinical Investigation. 124: 1835-43. PMID 24614107 DOI: 10.1172/Jci73441  0.464
2014 Holl TM, Yang G, Kuraoka M, Verkoczy L, Alam SM, Moody MA, Haynes BF, Kelsoe G. Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 192: 3269-79. PMID 24591365 DOI: 10.4049/Jimmunol.1302829  0.512
2014 Zhang J, Alam SM, Bouton-Verville H, Chen Y, Newman A, Stewart S, Jaeger FH, Montefiori DC, Dennison SM, Haynes BF, Verkoczy L. Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. Journal of Immunology (Baltimore, Md. : 1950). 192: 1693-706. PMID 24465011 DOI: 10.4049/Jimmunol.1302511  0.479
2013 Verkoczy L, Chen Y, Zhang J, Bouton-Verville H, Newman A, Lockwood B, Scearce RM, Montefiori DC, Dennison SM, Xia SM, Hwang KK, Liao HX, Alam SM, Haynes BF. Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. Journal of Immunology (Baltimore, Md. : 1950). 191: 2538-50. PMID 23918977 DOI: 10.4049/Jimmunol.1300971  0.496
2013 Chen Y, Zhang J, Hwang KK, Bouton-Verville H, Xia SM, Newman A, Ouyang YB, Haynes BF, Verkoczy L. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. Journal of Immunology (Baltimore, Md. : 1950). 191: 1260-75. PMID 23825311 DOI: 10.4049/Jimmunol.1300770  0.492
2013 Haynes BF, Kepler TB, Alam SM, Harrison S, Bonsignori M, Moody MA, Kelsoe G, Verkoczy L, Liao H. E108 Analysis of Broad Neutralizing B Cell Lineages to Guide HIV-1 Immunogen Design Jaids Journal of Acquired Immune Deficiency Syndromes. 62: S54. DOI: 10.1097/01.Qai.0000429246.24534.32  0.459
2012 Bonsignori M, Alam SM, Liao HX, Verkoczy L, Tomaras GD, Haynes BF, Moody MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends in Microbiology. 20: 532-9. PMID 22981828 DOI: 10.1016/J.Tim.2012.08.011  0.426
2011 Alam SM, Liao HX, Dennison SM, Jaeger F, Parks R, Anasti K, Foulger A, Donathan M, Lucas J, Verkoczy L, Nicely N, Tomaras GD, Kelsoe G, Chen B, Kepler TB, et al. Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation. Journal of Virology. 85: 11725-31. PMID 21917975 DOI: 10.1128/Jvi.05680-11  0.435
2011 Verkoczy L, Chen Y, Bouton-Verville H, Zhang J, Diaz M, Hutchinson J, Ouyang YB, Alam SM, Holl TM, Hwang KK, Kelsoe G, Haynes BF. Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. Journal of Immunology (Baltimore, Md. : 1950). 187: 3785-97. PMID 21908739 DOI: 10.4049/Jimmunol.1101633  0.464
2011 Verkoczy L, Kelsoe G, Moody MA, Haynes BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Current Opinion in Immunology. 23: 383-90. PMID 21524897 DOI: 10.1016/J.Coi.2011.04.003  0.459
2010 Haynes BF, Moody MA, Liao HX, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends in Molecular Medicine. 17: 108-16. PMID 21112250 DOI: 10.1016/J.Molmed.2010.10.008  0.499
2010 Shen X, Dennison SM, Liu P, Gao F, Jaeger F, Montefiori DC, Verkoczy L, Haynes BF, Alam SM, Tomaras GD. Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. Proceedings of the National Academy of Sciences of the United States of America. 107: 5972-7. PMID 20231447 DOI: 10.1073/Pnas.0912381107  0.376
2010 Verkoczy L, Diaz M, Holl TM, Ouyang YB, Bouton-Verville H, Alam SM, Liao HX, Kelsoe G, Haynes BF. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proceedings of the National Academy of Sciences of the United States of America. 107: 181-6. PMID 20018688 DOI: 10.1073/Pnas.0912914107  0.484
2009 Verkoczy L, Moody MA, Holl TM, Bouton-Verville H, Scearce RM, Hutchinson J, Alam SM, Kelsoe G, Haynes BF. Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. Plos One. 4: e7215. PMID 19806186 DOI: 10.1371/Journal.Pone.0007215  0.477
2009 Richter K, Brar S, Ray M, Pisitkun P, Bolland S, Verkoczy L, Diaz M. Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. The Journal of Biological Chemistry. 284: 30652-61. PMID 19734146 DOI: 10.1074/Jbc.M109.014506  0.424
2009 Holl T, Kuraoka M, Liao D, Verkoczy L, Moody M, Alam M, Liao H, Haynes B, Kelsoe G. P04-44. Generation of antibody responses to HIV-1 membrane proximal external region (MPER) antigen Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P72  0.32
2009 Holl TM, Kuraoka M, Liao D, Verkoczy L, Moody MA, Alam M, Liao H, Haynes BF, Kelsoe GH. P04-44. Generation of antibody responses to HIV-1 membrane proximal external region (MPER) antigen Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P72  0.421
2009 Verkoczy L, Diaz M, Holl TM, Ouyang Y, Bouton-Verville H, Alam SM, Liao H, Kelsoe G, Haynes BF. P04-26. Immunological tolerance prevents the expression of a broadly reactive neutralizing HIV-1 antibody Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P54  0.482
2009 Shen X, Dennison M, Gao F, Montefiori D, Verkoczy L, Haynes B, Alam M, Tomaras G. OA021-04. HIV-1 gp41 envelope MPER mutation altered epitope conformation in lipid and increased sensitivity to 2F5 and 4E10 neutralizing antibodies Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-O16  0.439
2009 Schroeder H, Kapoor P, Shaw G, Parks R, Alam S, Verkoczy L, Haynes B. T.59. The Composition of the Primary Immunoglobulin Repertoire Influences HIV gp140 Epitope Selection Clinical Immunology. 131: S66-S67. DOI: 10.1016/J.Clim.2009.03.194  0.38
2007 Verkoczy L, Duong B, Skog P, Aït-Azzouzene D, Puri K, Vela JL, Nemazee D. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. Journal of Immunology (Baltimore, Md. : 1950). 178: 6332-41. PMID 17475862 DOI: 10.4049/Jimmunol.178.10.6332  0.445
2006 Aït-Azzouzene D, Verkoczy L, Duong B, Skog P, Gavin AL, Nemazee D. Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand. Journal of Immunology (Baltimore, Md. : 1950). 176: 939-48. PMID 16393979 DOI: 10.4049/Jimmunol.176.2.939  0.445
2005 Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Human Antibodies. 14: 59-67. PMID 16720975 DOI: 10.3233/Hab-2005-143-402  0.492
2005 Verkoczy L, Aït-Azzouzene D, Skog P, Märtensson A, Lang J, Duong B, Nemazee D. A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity. 22: 519-31. PMID 15845455 DOI: 10.1016/J.Immuni.2005.03.006  0.454
2005 Ait-Azzouzene D, Verkoczy L, Peters J, Gavin A, Skog P, Vela JL, Nemazee D. An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. The Journal of Experimental Medicine. 201: 817-28. PMID 15738053 DOI: 10.1084/Jem.20041854  0.45
2004 Verkoczy LK, Mårtensson AS, Nemazee D. The scope of receptor editing and its association with autoimmunity. Current Opinion in Immunology. 16: 808-14. PMID 15511677 DOI: 10.1016/J.Coi.2004.09.017  0.425
2004 Gavin A, Aït-Azzouzene D, MÃ¥rtensson A, Duong B, Verkoczy L, Vela JL, Skog JL, Skog P, Nemazee D. Peripheral B lymphocyte tolerance. The Keio Journal of Medicine. 53: 151-8. PMID 15477728 DOI: 10.2302/Kjm.53.151  0.472
2004 Aït-Azzouzene D, Skog P, Retter M, Kouskoff V, Hertz M, Lang J, Kench J, Chumley M, Melamed D, Sudaria J, Gavin A, Martensson A, Verkoczy L, Duong B, Vela J, et al. Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. Immunological Reviews. 197: 219-30. PMID 14962198 DOI: 10.1111/J.0105-2896.2004.0106.X  0.459
2003 Diaz M, Ray M, Wheeler LJ, Verkoczy LK, Mathews CK. Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool. Molecular Immunology. 40: 261-8. PMID 12943798 DOI: 10.1016/S0161-5890(03)00113-5  0.36
2002 Nemazee D, Mårtensson A, Verkoczy L. Haplotype exclusion and receptor editing: irreconcilable differences? Seminars in Immunology. 14: 191-8; discussion 22. PMID 12160646 DOI: 10.1016/S1044-5323(02)00042-8  0.391
2001 Diaz M, Verkoczy LK, Flajnik MF, Klinman NR. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ1 Journal of Immunology. 167: 327-335. PMID 11418667 DOI: 10.4049/Jimmunol.167.1.327  0.366
2000 Verkoczy LK, Guinn Ba, Berinstein NL. Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. The Journal of Biological Chemistry. 275: 20967-79. PMID 10749872 DOI: 10.1074/Jbc.M001866200  0.641
1998 Verkoczy LK, Marsden PA, Berinstein NL. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). European Journal of Immunology. 28: 2839-53. PMID 9754571 DOI: 10.1002/(Sici)1521-4141(199809)28:09<2839::Aid-Immu2839>3.0.Co;2-6  0.619
1998 Verkoczy LK, Berinstein NL. Isolation of genes negatively or positively co-expressed with human recombination activating gene 1 (RAG1) by differential display PCR (DD RT-PCR). Nucleic Acids Research. 26: 4497-507. PMID 9742255 DOI: 10.1093/Nar/26.19.4497  0.571
1995 Stiernholm NB, Verkoczy LK, Berinstein NL. Rearrangement and expression of the human psi C lambda 6 gene segment results in a surface Ig receptor with a truncated light chain constant region. Journal of Immunology (Baltimore, Md. : 1950). 154: 4583-91. PMID 7722311  0.546
1995 Verkoczy LK, Stiernhdm BJ, Berinstein NL. Up-regulation of recombination activating gene expression by signal transduction through the surface Ig receptor. Journal of Immunology (Baltimore, Md. : 1950). 154: 5136-43. PMID 7537300  0.616
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