| Year |
Citation |
Score |
| 2024 |
Azaria RD, Correia AB, Schache KJ, Zapata M, Pathmasiri KC, Mohanty V, Nannapaneni DT, Ashfeld BL, Helquist P, Wiest O, Ohgane K, Li Q, Fredenburg RA, Blagg BS, Cologna SM, et al. Mutant induced neurons and humanized mice enable identification of Niemann-Pick C1 proteostatic therapies. Jci Insight. PMID 39207850 DOI: 10.1172/jci.insight.179525 |
0.695 |
|
| 2024 |
Wiest O, Bauer C, Helquist P, Norrby PO, Genheden S. Finding Relevant Retrosynthetic Disconnections for Stereocontrolled Reactions. Journal of Chemical Information and Modeling. PMID 38995078 DOI: 10.1021/acs.jcim.4c00370 |
0.728 |
|
| 2024 |
Purohit V, Steussy CN, Rosales AR, Critchelow CJ, Schmidt T, Helquist P, Wiest O, Mesecar A, Cohen AE, Stauffacher CV. pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophysical Journal. PMID 38327055 DOI: 10.1016/j.bpj.2024.02.003 |
0.778 |
|
| 2023 |
Patel HN, Haines BE, Stauffacher CV, Helquist P, Wiest O. Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in HMG-CoA Reductase. The Journal of Physical Chemistry. B. PMID 37219997 DOI: 10.1021/acs.jpcb.2c08969 |
0.664 |
|
| 2023 |
Maloney MP, Coley CW, Genheden S, Carson N, Helquist P, Norrby PO, Wiest O. Negative Data in Data Sets for Machine Learning Training. Organic Letters. 25: 2945-2947. PMID 37126483 DOI: 10.1021/acs.orglett.3c01282 |
0.744 |
|
| 2023 |
Maloney MP, Coley CW, Genheden S, Carson N, Helquist P, Norrby PO, Wiest O. Negative Data in Data Sets for Machine Learning Training. The Journal of Organic Chemistry. 88: 5239-5241. PMID 37126471 DOI: 10.1021/acs.joc.3c00844 |
0.744 |
|
| 2022 |
Wahlers J, Rosales AR, Berkel N, Forbes A, Helquist P, Norrby PO, Wiest O. A Quantum-Guided Molecular Mechanics Force Field for the Ferrocene Scaffold. The Journal of Organic Chemistry. 87: 12334-12341. PMID 36066498 DOI: 10.1021/acs.joc.2c01553 |
0.775 |
|
| 2022 |
Quinn TR, Patel HN, Koh KH, Haines BE, Norrby PO, Helquist P, Wiest O. Automated fitting of transition state force fields for biomolecular simulations. Plos One. 17: e0264960. PMID 35271647 DOI: 10.1371/journal.pone.0264960 |
0.72 |
|
| 2021 |
Wahlers J, Margalef J, Hansen E, Bayesteh A, Helquist P, Diéguez M, Pàmies O, Wiest O, Norrby PO. Proofreading experimentally assigned stereochemistry through Q2MM predictions in Pd-catalyzed allylic aminations. Nature Communications. 12: 6719. PMID 34795274 DOI: 10.1038/s41467-021-27065-2 |
0.753 |
|
| 2021 |
Pipalia NH, Saad SZ, Subramanian K, Cross A, Al-Motawa A, Garg K, Blagg BSJ, Neckers L, Helquist P, Wiest O, Ory DS, Maxfield FR. HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts. Journal of Lipid Research. 100114. PMID 34481829 DOI: 10.1016/j.jlr.2021.100114 |
0.696 |
|
| 2021 |
Cruz DL, Pipalia N, Mao S, Gadi D, Liu G, Grigalunas M, O'Neill M, Quinn TR, Kipper A, Ekebergh A, Dimmling A, Gartner C, Melancon BJ, Wagner FF, Holson E, ... Helquist P, et al. Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts. Acs Pharmacology & Translational Science. 4: 1136-1148. PMID 34151204 DOI: 10.1021/acsptsci.1c00033 |
0.615 |
|
| 2021 |
Quinn TR, Steussy CN, Haines BE, Lei J, Wang W, Sheong FK, Stauffacher CV, Huang X, Norrby PO, Helquist P, Wiest O. Microsecond timescale MD simulations at the transition state of HMGR predict remote allosteric residues. Chemical Science. 12: 6413-6418. PMID 34084441 DOI: 10.1039/d1sc00102g |
0.706 |
|
| 2021 |
Wahlers J, Maloney M, Salahi F, Rosales AR, Helquist P, Norrby PO, Wiest O. Stereoselectivity Predictions for the Pd-Catalyzed 1,4-Conjugate Addition Using Quantum-Guided Molecular Mechanics. The Journal of Organic Chemistry. PMID 33769065 DOI: 10.1021/acs.joc.1c00136 |
0.781 |
|
| 2020 |
Work EM, Ferraudi G, Kiefer L, Liu G, Grigalunas M, Bhardwaj A, Kaur R, Dempsey JM, Wüstner D, Helquist P, Wiest O. Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic. The Journal of Organic Chemistry. PMID 33369429 DOI: 10.1021/acs.joc.0c02460 |
0.63 |
|
| 2020 |
Rosales A, Ross SP, Helquist P, Norrby PO, Sigman MS, Wiest O. Transition State Force Field for the Asymmetric Redox Relay Heck Reaction. Journal of the American Chemical Society. PMID 32249569 DOI: 10.1021/Jacs.0C01979 |
0.791 |
|
| 2020 |
Purohit V, Rosales T, Critchelow C, Steussy C, Schmidt T, Wiest O, Helquist P, Stauffacher CV. Developing a pH-Jump Chemical Triggering Method for Time-Resolved Diffraction in Bacterial HMG-CoA Reductase Biophysical Journal. 118: 137a. DOI: 10.1016/J.Bpj.2019.11.875 |
0.627 |
|
| 2019 |
Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, et al. 2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31051283 DOI: 10.1016/J.Bbalip.2019.04.011 |
0.763 |
|
| 2018 |
Rosales AR, Quinn TR, Wahlers J, Tomberg A, Zhang X, Helquist P, Wiest O, Norrby PO. Application of Q2MM to predictions in stereoselective synthesis. Chemical Communications (Cambridge, England). PMID 29971313 DOI: 10.1039/C8Cc03695K |
0.8 |
|
| 2018 |
Salahi F, Purohit V, Ferraudi G, Stauffacher C, Wiest O, Helquist P. pHP-Tethered N-Acyl Carbamate: A Photocage for Nicotinamide. Organic Letters. 20: 2547-2550. PMID 29652162 DOI: 10.1021/Acs.Orglett.8B00697 |
0.774 |
|
| 2018 |
Rosales AR, Wahlers J, Limé E, Meadows RE, Leslie KW, Savin R, Bell F, Hansen E, Helquist P, Munday RH, Wiest O, Norrby P. Rapid virtual screening of enantioselective catalysts using CatVS Nature Catalysis. 2: 41-45. DOI: 10.1038/s41929-018-0193-3 |
0.763 |
|
| 2018 |
Zhang X, Tutkowski B, Oliver A, Helquist P, Wiest O. Mechanistic Study of the Nickel-Catalyzed α,β-Coupling of Saturated Ketones Acs Catalysis. 8: 1740-1747. DOI: 10.1021/Acscatal.7B04105 |
0.672 |
|
| 2017 |
Tutkowski B, Kerdphon S, Limé E, Helquist P, Andersson PG, Wiest O, Norrby P. Revisiting the Stereodetermining Step in Enantioselective Iridium-Catalyzed Imine Hydrogenation Acs Catalysis. 8: 615-623. DOI: 10.1021/Acscatal.7B02386 |
0.736 |
|
| 2016 |
Grigalunas M, Wiest O, Helquist P. Single-Flask Multicomponent Synthesis of Highly Substituted α-Pyrones via a Sequential Enolate Arylation and Alkenylation Strategy. Organic Letters. 18: 5724-5727. PMID 27768319 DOI: 10.1021/Acs.Orglett.6B02969 |
0.665 |
|
| 2016 |
Lee JM, Zhang X, Norrby PO, Helquist P, Wiest O. Stereoselectivity in (Acyloxy)borane-Catalyzed Mukaiyama Aldol Reactions. The Journal of Organic Chemistry. PMID 27247023 DOI: 10.1021/Acs.Joc.6B00594 |
0.785 |
|
| 2016 |
Purohit V, Salahi F, Steussy N, Helquist P, Weist O, Stauffacher C. Synthesizing Caged-NAD Molecules to Conduct Laue Time-Resolved Crystallography Measurements on HMGCoA Reductase Biophysical Journal. 110: 550a. DOI: 10.1016/J.Bpj.2015.11.2943 |
0.771 |
|
| 2015 |
Grigalunas M, Norrby PO, Wiest O, Helquist P. Single-Flask Multicomponent Palladium-Catalyzed α,γ-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds. Angewandte Chemie (International Ed. in English). 54: 11822-5. PMID 26276904 DOI: 10.1002/Anie.201505895 |
0.738 |
|
| 2015 |
Grigalunas M, Ankner T, Norrby PO, Wiest O, Helquist P. Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization. Journal of the American Chemical Society. 137: 7019-22. PMID 26024472 DOI: 10.1021/Jacs.5B02945 |
0.735 |
|
| 2015 |
Byrd KM, Arieno MD, Kennelly ME, Estiu G, Wiest O, Helquist P. Design and synthesis of a crosslinker for studying intracellular steroid trafficking pathways. Bioorganic & Medicinal Chemistry. 23: 3843-51. PMID 25890696 DOI: 10.1016/J.Bmc.2015.03.053 |
0.709 |
|
| 2015 |
Tutkowski BM, Grigalunas M, Wiest O, Helquist P. A nickel-catalyzed α,β-coupling of saturated ketones Tetrahedron Letters. 56: 3468-3472. DOI: 10.1016/J.Tetlet.2015.02.061 |
0.67 |
|
| 2015 |
Tutkowski BM, Grigalunas M, Wiest O, Helquist P. ChemInform Abstract: A Nickel-Catalyzed α,β-Coupling of Saturated Ketones. Cheminform. 46: no-no. DOI: 10.1002/chin.201538102 |
0.626 |
|
| 2014 |
Limé E, Lundholm MD, Forbes A, Wiest O, Helquist P, Norrby PO. Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation. Journal of Chemical Theory and Computation. 10: 2427-35. PMID 26580763 DOI: 10.1021/Ct500178W |
0.753 |
|
| 2014 |
Grigalunas M, Ankner T, Norrby PO, Wiest O, Helquist P. Palladium-catalyzed alkenylation of ketone enolates under mild conditions. Organic Letters. 16: 3970-3. PMID 25032503 DOI: 10.1021/Ol5017965 |
0.745 |
|
| 2014 |
Pearson GL, Mellett N, Chu KY, Cantley J, Davenport A, Bourbon P, Cosner CC, Helquist P, Meikle PJ, Biden TJ. Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells. Diabetologia. 57: 129-39. PMID 24149836 DOI: 10.1007/S00125-013-3083-X |
0.669 |
|
| 2014 |
Limé E, Lundholm MD, Forbes A, Wiest O, Helquist P, Norrby PO. Stereoselectivity in asymmetric catalysis: The case of ruthenium-catalyzed ketone hydrogenation Journal of Chemical Theory and Computation. 10: 2427-2435. DOI: 10.1021/ct500178w |
0.72 |
|
| 2014 |
Forbes A, Verdolino V, Helquist P, Wiest O. Transition metal-catalyzed hydrogenations Computational Organometallic Chemistry. 61-112. DOI: 10.1007/978-3-642-25258-7_4 |
0.608 |
|
| 2013 |
Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide. Bioorganic & Medicinal Chemistry Letters. 23: 6321-4. PMID 24125882 DOI: 10.1016/J.Bmcl.2013.09.067 |
0.756 |
|
| 2013 |
Helquist P, Maxfield FR, Wiech NL, Wiest O. Treatment of Niemann--pick type C disease by histone deacetylase inhibitors. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 688-97. PMID 24048860 DOI: 10.1007/S13311-013-0217-2 |
0.609 |
|
| 2013 |
Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Synthesis and photochemical behavior of coumarin-caged cholesterol. Bioorganic & Medicinal Chemistry Letters. 23: 2162-5. PMID 23434228 DOI: 10.1016/J.Bmcl.2013.01.095 |
0.736 |
|
| 2013 |
Ankner T, Cosner CC, Helquist P. Palladium- and nickel-catalyzed alkenylation of enolates Chemistry - a European Journal. 19: 1858-1871. PMID 23325616 DOI: 10.1002/chem.201202798 |
0.655 |
|
| 2013 |
Cosner CC, Bhaskara Reddy Iska V, Chatterjee A, Markiewicz JT, Corden SJ, Löfstedt J, Ankner T, Richer J, Hulett T, Schauer DJ, Wiest O, Helquist P. Evolution of concise and flexible synthetic strategies for trichostatic acid and the potent histone deacetylase inhibitor trichostatin A European Journal of Organic Chemistry. 162-172. DOI: 10.1002/Ejoc.201201233 |
0.79 |
|
| 2012 |
Wehrmann ZT, Hulett TW, Huegel KL, Vaughan KT, Wiest O, Helquist P, Goodson H. Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts. Plos One. 7: e48561. PMID 23144769 DOI: 10.1371/Journal.Pone.0048561 |
0.617 |
|
| 2012 |
Lee JM, Helquist P, Wiest O. Diastereoselectivity in Lewis-acid-catalyzed Mukaiyama aldol reactions: a DFT study. Journal of the American Chemical Society. 134: 14973-81. PMID 22891640 DOI: 10.1021/Ja3052975 |
0.754 |
|
| 2012 |
Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives. The Journal of Organic Chemistry. 77: 2756-62. PMID 22360284 DOI: 10.1021/Jo2025527 |
0.751 |
|
| 2011 |
Wiest O, Helquist P. Chemistry. Striking a balance to control stereochemistry. Science (New York, N.Y.). 333: 1831-2. PMID 21960616 DOI: 10.1126/science.1211195 |
0.599 |
|
| 2011 |
Cosner CC, Helquist P. Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. Organic Letters. 13: 3564-7. PMID 21688856 DOI: 10.1021/Ol200964M |
0.673 |
|
| 2011 |
Chen Q, Schweitzer D, Kane J, Davisson VJ, Helquist P. Total synthesis of iejimalide B. The Journal of Organic Chemistry. 76: 5157-69. PMID 21488673 DOI: 10.1021/Jo200514M |
0.635 |
|
| 2011 |
Pipalia NH, Cosner CC, Huang A, Chatterjee A, Bourbon P, Farley N, Helquist P, Wiest O, Maxfield FR. Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 108: 5620-5. PMID 21436030 DOI: 10.1073/Pnas.1014890108 |
0.768 |
|
| 2011 |
Cosner CC, Cabrera PJ, Byrd KM, Thomas AM, Helquist P. Selective oxidation of benzylic and allylic alcohols using Mn(OAc)3/catalytic 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Organic Letters. 13: 2071-3. PMID 21395252 DOI: 10.1021/Ol200441G |
0.699 |
|
| 2011 |
Wiest O, Helquist P. Chemistry: Striking a balance to control stereochemistry Science. 333: 1831-1832. DOI: 10.1126/Science.1211195 |
0.679 |
|
| 2010 |
Markiewicz JT, Wiest O, Helquist P. Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide. The Journal of Organic Chemistry. 75: 4887-90. PMID 20568788 DOI: 10.1021/Jo101002P |
0.809 |
|
| 2010 |
Rosenbaum AI, Cosner CC, Mariani CJ, Maxfield FR, Wiest O, Helquist P. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 53: 5281-9. PMID 20557099 DOI: 10.1021/Jm100499S |
0.774 |
|
| 2010 |
Homan KT, Balasubramaniam D, Zabell APR, Wiest O, Helquist P, Stauffacher CV. Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening Bioorganic and Medicinal Chemistry. 18: 5449-5456. PMID 20538467 DOI: 10.1016/J.Bmc.2010.04.050 |
0.625 |
|
| 2010 |
Markiewicz JT, Schauer DJ, Löfstedt J, Corden SJ, Wiest O, Helquist P. Synthesis of 4-methyldienoates using a vinylogous Horner-Wadsworth-Emmons reagent. Application to the synthesis of trichostatic acid. The Journal of Organic Chemistry. 75: 2061-4. PMID 20158219 DOI: 10.1021/Jo902422Y |
0.794 |
|
| 2010 |
Chatterjee A, Richer J, Hulett T, Iska VBR, Wiest O, Helquist P. An efficient synthesis of (±)-trichostatic acid and analogues: A new route to (±)-trichostatin A Organic Letters. 12: 832-834. PMID 20104892 DOI: 10.1021/Ol9029116 |
0.695 |
|
| 2010 |
Iska VBR, Verdolino V, Wiest O, Helquist P. Mild and efficient desymmetrization of diynes via hydroamination: Application to the synthesis of (±)-monomorine I Journal of Organic Chemistry. 75: 1325-1328. PMID 20088529 DOI: 10.1021/Jo902674J |
0.698 |
|
| 2010 |
Verdolino V, Forbes A, Helquist P, Norrby PO, Wiest O. On the mechanism of the rhodium catalyzed acrylamide hydrogenation Journal of Molecular Catalysis a: Chemical. 324: 9-14. DOI: 10.1016/J.Molcata.2010.02.026 |
0.741 |
|
| 2009 |
Cosner CC, Markiewicz JT, Bourbon P, Mariani CJ, Wiest O, Rujoi M, Rosenbaum AI, Huang AY, Maxfield FR, Helquist P. Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. Journal of Medicinal Chemistry. 52: 6494-8. PMID 19772346 DOI: 10.1021/Jm900707N |
0.776 |
|
| 2009 |
Wiech NL, Fisher JF, Helquist P, Wiest O. Inhibition of histone deacetylases: A pharmacological approach to the treatment of non-cancer disorders Current Topics in Medicinal Chemistry. 9: 257-271. PMID 19355990 DOI: 10.2174/156802609788085241 |
0.642 |
|
| 2009 |
Donoghue PJ, Helquist P, Norrby PO, Wiest O. Prediction of enantioselectivity in rhodium catalyzed hydrogenations. Journal of the American Chemical Society. 131: 410-1. PMID 19140780 DOI: 10.1021/Ja806246H |
0.733 |
|
| 2009 |
Helquist P, Wiest O. Current status of drug therapy development for Niemann-Pick type C disease Drugs of the Future. 34: 315-331. DOI: 10.1358/Dof.2009.034.04.1352412 |
0.593 |
|
| 2008 |
Donoghue PJ, Helquist P, Norrby PO, Wiest O. Development of a Q2MM Force Field for the Asymmetric Rhodium Catalyzed Hydrogenation of Enamides. Journal of Chemical Theory and Computation. 4: 1313-23. PMID 26631706 DOI: 10.1021/Ct800132A |
0.74 |
|
| 2008 |
Carney JM, Donoghue PJ, Wuest WM, Wiest O, Helquist P. Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts. Organic Letters. 10: 3903-6. PMID 18662005 DOI: 10.1021/Ol801458G |
0.794 |
|
| 2008 |
Plummer JM, Weitgenant JA, Noll BC, Lauher JW, Wiest O, Helquist P. Synthesis, structure, and metal complexation behavior of a new type of functionalized chiral phenanthroline derivative. The Journal of Organic Chemistry. 73: 3911-4. PMID 18399656 DOI: 10.1021/Jo702566M |
0.764 |
|
| 2008 |
Plummer JM, Weitgenant JA, Noll BC, Lauher JW, Wiest O, Helquist P. Synthesis, structure, and metal complexation behavior of a new type of functionalized chiral phenanthroline derivative (Journal of Organic Chemistry (2008) 73, (3914)) Journal of Organic Chemistry. 73: 7856. DOI: 10.1021/jo801857y |
0.595 |
|
| 2008 |
Donoghue PJ, Helquist P, Norrby PO, Wiest O. Development of a Q2MM force field for the asymmetric rhodium catalyzed hydrogenation of enamides Journal of Chemical Theory and Computation. 4: 1313-1323. DOI: 10.1021/ct800132a |
0.707 |
|
| 2007 |
Schweitzer D, Kane JJ, Strand D, McHenry P, Tenniswood M, Helquist P. Total synthesis of iejimalide B. An application of the Shiina macrolactonization. Organic Letters. 9: 4619-22. PMID 17915890 DOI: 10.1021/Ol702129W |
0.685 |
|
| 2007 |
Wang D, Helquist P, Wiest O. Zinc binding in HDAC inhibitors: A DFT study Journal of Organic Chemistry. 72: 5446-5449. PMID 17579460 DOI: 10.1021/Jo070739S |
0.656 |
|
| 2007 |
Donoghue PJ, Helquist P, Wiest O. Ligand and substrate effects on the mechanism of rhodium-catalyzed hydrogenation of enamides. The Journal of Organic Chemistry. 72: 839-47. PMID 17253803 DOI: 10.1021/Jo0619276 |
0.67 |
|
| 2007 |
Donoghue PJ, Kieken E, Helquist P, Wiest O. Development of a Q2MM force field for the silver(I)-catalyzed hydroamination of alkynes Advanced Synthesis and Catalysis. 349: 2647-2654. DOI: 10.1002/Adsc.200700374 |
0.662 |
|
| 2006 |
Weitgenant JA, Katsuyama I, Bigi MA, Corden SJ, Markiewicz JT, Zabell APR, Homan KT, Wiest O, Stauffacher CV, Helquist P. Synthesis of a 5-azaindole phosphonic acid as a computationally designed inhibitor of the low molecular weight phosphatase HCPTP Heterocycles. 70: 599-607. DOI: 10.3987/Com-06-S(W)38 |
0.783 |
|
| 2006 |
Schauer DJ, Helquist P. Mild zinc-promoted Horner-Wadsworth-Emmons reactions of diprotic phosphonate reagents Synthesis. 3654-3660. DOI: 10.1055/S-2006-950292 |
0.8 |
|
| 2005 |
Wang DF, Helquist P, Wiech NL, Wiest O. Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases. Journal of Medicinal Chemistry. 48: 6936-47. PMID 16250652 DOI: 10.1021/Jm0505011 |
0.644 |
|
| 2005 |
Weitgenant JA, Mortison JD, Helquist P. Samarium-promoted coupling of pyridine-based heteroaryl analogues of benzylic acetates with carbonyl compounds. Organic Letters. 7: 3609-12. PMID 16092831 DOI: 10.1021/Ol050944Z |
0.397 |
|
| 2005 |
Kieken E, Wiest O, Helquist P, Cucciolito ME, Flores G, Vitagliano A, Norrby PO. Chiral diamine-silver (I)-alkene complexes: A quantum chemical and NMR study Organometallics. 24: 3737-3745. DOI: 10.1021/Om050275T |
0.746 |
|
| 2004 |
Slough GA, Krchnák V, Helquist P, Canham SM. Synthesis of readily cleavable immobilized 1,10-phenanthroline resins. Organic Letters. 6: 2909-12. PMID 15330645 DOI: 10.1021/Ol049101I |
0.412 |
|
| 2004 |
Wang DF, Wiest O, Helquist P, Lan-Hargest HY, Wiech NL. On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors. Journal of Medicinal Chemistry. 47: 3409-17. PMID 15189037 DOI: 10.1021/Jm0498497 |
0.649 |
|
| 2004 |
Ding P, Miller MJ, Chen Y, Helquist P, Oliver AJ, Wiest O. Syntheses of conformationally constricted molecules as potential NAALADase/PSMA inhibitors. Organic Letters. 6: 1805-8. PMID 15151419 DOI: 10.1021/Ol049473R |
0.675 |
|
| 2004 |
Weitgenant JA, Mortison JD, O'Neill DJ, Mowery B, Puranen A, Helquist P. Samarium-promoted coupling of 1,10-phenanthroline with carbonyl compounds for synthesis of new ligands. The Journal of Organic Chemistry. 69: 2809-15. PMID 15074932 DOI: 10.1021/Jo0303416 |
0.394 |
|
| 2004 |
Zabell APR, Corden S, Helquist P, Stauffacher CV, Wiest O. Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase Bioorganic and Medicinal Chemistry. 12: 1867-1880. PMID 15051056 DOI: 10.1016/J.Bmc.2004.01.042 |
0.627 |
|
| 2004 |
Wang DF, Wiest O, Helquist P, Lan-Hargest HY, Wiech NL. QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. Bioorganic & Medicinal Chemistry Letters. 14: 707-11. PMID 14741273 DOI: 10.1016/J.Bmcl.2003.11.062 |
0.622 |
|
| 2003 |
Oliver AJ, Wiest O, Helquist P, Miller MJ, Tenniswood M. Conformational and SAR analysis of NAALADase and PSMA inhibitors. Bioorganic & Medicinal Chemistry. 11: 4455-61. PMID 13129582 DOI: 10.1016/S0968-0896(03)00427-9 |
0.623 |
|
| 2002 |
Stauffacher CV, Zabell APR, Katsuyama I, Helquist P, Wiest O. Computationally designed inhibitors of the low molecular weight phosphatase HCPTP Acta Crystallographica Section a Foundations of Crystallography. 58: c62-c62. DOI: 10.1107/S0108767302087561 |
0.595 |
|
| 2001 |
Pedersen TM, Hansen EL, Kane J, Rein T, Helquist P, Norrby PO, Tanner D. Enantioconvergent synthesis by sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed allylic substitution reactions. Journal of the American Chemical Society. 123: 9738-42. PMID 11583534 DOI: 10.1021/Ja005809Q |
0.726 |
|
| 2001 |
Ishii S, Zhao S, Mehta G, Knors CJ, Helquist P. Intramolecular C-H insertion reactions of (η5-Cyclopentadienyl)dicarbonyliron carbene complexes: Scope of the reactions and application to the synthesis of (±)-sterpurene and (±)-pentalenene Journal of Organic Chemistry. 66: 3449-3458. PMID 11348129 DOI: 10.1021/Jo001792I |
0.383 |
|
| 2000 |
Ishii S, Zhao S, Helquist P. Stereochemical probes of intramolecular C-H insertion reactions of iron- carbene complexes [11] Journal of the American Chemical Society. 122: 5897-5898. DOI: 10.1021/Ja000239F |
0.307 |
|
| 1999 |
Tullis JS, Helquist P, Rein T. Synthetic applications of asymmetric Horner-Wadsworth-Emmons condensations: Approaches to marine natural products Phosphorus, Sulfur and Silicon and Related Elements. 144: 165-168. DOI: 10.1080/10426509908546208 |
0.794 |
|
| 1999 |
Palmgren A, Larsson ALE, Bäckvall JE, Helquist P. Palladium(II)-catalyzed 1,4-oxidation of 2-aryl-1,3-cyclohexadienes. Application to the synthesis of (±)-epibatidine and analogues Journal of Organic Chemistry. 64: 836-842. DOI: 10.1021/Jo981668N |
0.358 |
|
| 1997 |
Oslob JD, Åkermark B, Helquist P, Norrby PO. Steric influences on the selectivity in palladium-catalyzed allylation Organometallics. 16: 3015-3021. DOI: 10.1021/Om9700371 |
0.535 |
|
| 1997 |
Tullis JS, Helquist P. Rhodium-catalyzed heterocycloaddition of a diazomalonate and a nitrile: Synthesis of 4-carbomethoxy-5-methoxy-2-phenyl-1,3-oxazole (4-Oxazolecarboxylic acid, 5-methoxy-2-phenyl-, methyl ester) Organic Syntheses. 74: 229-239. |
0.8 |
|
| 1996 |
Peña-Cabrera E, Norrby PO, Sjögren M, Vitagliano A, De Felice V, Oslob J, Ishii S, O'Neill D, Åkermark B, Helquist P. Molecular mechanics predictions and experimental testing of asymmetric palladium-catalyzed allylation reactions using new chiral phenanthroline ligands Journal of the American Chemical Society. 118: 4299-4313. DOI: 10.1021/ja950860t |
0.547 |
|
| 1992 |
Gangloff AR, Akermark B, Helquist P. Generation and use of a zinc derivative of a functionalized 1,3-oxazole. Solution of the virginiamycin/madumycin oxazole problem Journal of Organic Chemistry. 57: 4797-4799. DOI: 10.1021/Jo00044A009 |
0.338 |
|
| 1991 |
Sellén M, Bäckvall JE, Helquist P. Synthesis of substituted cyclic 1,3-dienes via selective 1,4-elimination of benzenesulfinic acid from allylic phenyl sulfones Journal of Organic Chemistry. 56: 835-839. DOI: 10.1021/Jo00002A061 |
0.388 |
|
| 1989 |
Nyström JE, Helquist P. Short intramolecular Diels-Alder approach to spirovetivanes. Total synthesis of dl-hinesol Journal of Organic Chemistry. 54: 4695-4698. DOI: 10.1021/Jo00280A047 |
0.334 |
|
| 1989 |
Zhao SK, Knors C, Helquist P. Intramolecular carbon-hydrogen insertion reactions of (cyclopentadienyl)dicarbonyl iron carbene complexes Journal of the American Chemical Society. 111: 8527-8528. DOI: 10.1021/Ja00204A040 |
0.308 |
|
| 1988 |
Zhang WY, Jakiela DJ, Maul A, Knors C, Lauher JW, Helquist P, Enders D. Highly diastereofacial selective chelation of a phosphite-containing .alpha.,.beta.-unsaturated ketone system to the Fe(CO)2 group Journal of the American Chemical Society. 110: 4652-4660. DOI: 10.1021/Ja00222A026 |
0.407 |
|
| 1986 |
Iyer R, Kuo G, Helquist P. Additions and Corrections - Stereochemistry of Intramolecular Cyclopropanation of an Organoiron Reagent. The Journal of Organic Chemistry. 51: 2156-2156. DOI: 10.1021/Jo00361A606 |
0.359 |
|
| 1986 |
Carey JT, Knors C, Helquist P. Direct formation of a tricyclic cycloheptanone-containing system by enolate condensation with a cyclopropanone derivative Journal of the American Chemical Society. 108: 8313-8314. DOI: 10.1021/Ja00286A058 |
0.322 |
|
| 1986 |
BUTERA J, RINI J, HELQUIST P. ChemInform Abstract: Synthesis of α-Carbalkoxy Enethiols: A Class of Tautomeric Thiopyruvate Derivatives. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198612280 |
0.305 |
|
| 1985 |
Iyer RS, Kuo GH, Helquist P. Stereochemistry of intramolecular cyclopropanation of an organoiron reagent The Journal of Organic Chemistry. 50: 5898-5900. DOI: 10.1002/Chin.198630107 |
0.41 |
|
| 1985 |
Hwang DR, Helquist P, Shekhani MS. Total synthesis of (+)-sparsomycin. Approaches using cysteine and serine inversion The Journal of Organic Chemistry. 50: 1264-1271. DOI: 10.1002/Chin.198535344 |
0.309 |
|
| 1984 |
Nikaido M, Aslanian R, Scavo F, Helquist P, Aakermark B, Baeckvall JE. Direct preparation of 5-amino-1,3-pentadienes through use of palladium-promoted reactions The Journal of Organic Chemistry. 49: 4738-4740. DOI: 10.1021/Jo00198A036 |
0.306 |
|
| 1983 |
BAL SA, MARFAT A, HELQUIST P. ChemInform Abstract: CYCLOPENTENE AND CYCLOHEXENE ANNULATION VIA COPPER-CATALYZED CONJUGATE ADDITION OF ACETAL-CONTAINING GRIGNARD REAGENTS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198322121 |
0.752 |
|
| 1982 |
Bal SA, Marfat A, Helquist P. Cyclopentene and cyclohexene annulation via copper-catalyzed conjugate addition of acetal-containing Grignard reagents The Journal of Organic Chemistry. 47: 5045-5050. DOI: 10.1021/Jo00147A001 |
0.764 |
|
| 1982 |
SEMMELHACK MF, HELQUIST P, JONES LD, KELLER L, MENDELSON L, RYONO LS, GORZYNSKI SMITH J, STAUFFER RD. ChemInform Abstract: REACTION OF ARYL AND VINYL HALIDES WITH ZEROVALENT NICKEL - PREPARATIVE ASPECTS AND THE SYNTHESIS OF ALNUSONE Chemischer Informationsdienst. 13. DOI: 10.1002/chin.198205160 |
0.315 |
|
| 1981 |
Yu L, Helquist P. .beta.-Amino ester enolate as an acrylate anion equivalent for the synthesis of .alpha.-methylene esters, acids, and lactones The Journal of Organic Chemistry. 46: 4536-4541. DOI: 10.1021/Jo00335A043 |
0.302 |
|
| 1981 |
Ponton J, Helquist P, Conrad PC, Fuchs PL. Six-membered-ring annulation via a conjugate addition-alkylation sequence using functionalized aryllithium reagents and vinyl sulfones The Journal of Organic Chemistry. 46: 118-122. DOI: 10.1021/Jo00314A026 |
0.51 |
|
| 1981 |
Bornack WK, Bhagwat SS, Ponton J, Helquist P. Preparation of lactone systems. Total synthesis of (.+-.)-quadrone Journal of the American Chemical Society. 103: 4647-4648. DOI: 10.1021/Ja00405A091 |
0.309 |
|
| 1981 |
Semmelhack MF, Helquist P, Jones LD, Keller L, Mendelson L, Ryono LS, Smith JG, Stauffer RD. Reaction of aryl and vinyl halides with zerovalent nickel-preparative aspects and the synthesis of alnusone Journal of the American Chemical Society. 103: 6460-6471. DOI: 10.1002/Chin.198205160 |
0.801 |
|
| 1980 |
MARFAT A, MCGUIRK PR, HELQUIST P. ChemInform Abstract: HIGHLY STEREOSELECTIVE SYNTHESIS OF TRISUBSTITUTED OLEFINS VIA ADDITION OF ALKYLCOPPER COMPLEXES TO ACETYLENES Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198018136 |
0.762 |
|
| 1979 |
Marfat A, McGuirk PR, Helquist P. Highly stereoselective synthesis of trisubstituted olefins via addition of alkylcopper complexes to acetylenes The Journal of Organic Chemistry. 44: 3888-3901. DOI: 10.1021/Jo01336A029 |
0.773 |
|
| 1979 |
Marfat A, McGuirk PR, Helquist P. Iterative construction of trisubstituted olefin units. Short, stereoselective synthesis of the codling moth constituent, (2Z,6Z)-7-methyl-3-propyl-2,6-decadien-1-ol The Journal of Organic Chemistry. 44: 1345-1347. DOI: 10.1021/Jo01322A034 |
0.746 |
|
| 1979 |
Helquist P, Saleh Shekhani M. Total synthesis of (RC)-sparsomycin Journal of the American Chemical Society. 101: 1057-1059. DOI: 10.1021/Ja00498A058 |
0.346 |
|
| 1979 |
Brandt S, Marfat A, Helquist P. A short, efficient, synthetic pathway to the 6,7,8,9-tetrahydro-5h-dibenz[d,f]azonine system Tetrahedron Letters. 20: 2193-2194. DOI: 10.1016/S0040-4039(01)93673-1 |
0.693 |
|
| 1979 |
BRANDT S, MARFAT A, HELQUIST P. ChemInform Abstract: A SHORT, EFFICIENT, SYNTHETIC PATH TO THE 6,7,8,9-TETRAHYDRO-5H-DIBENZ(D,F)>AZONINE SYSTEM Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197939188 |
0.695 |
|
| 1979 |
MARFAT A, HELQUIST P. ChemInform Abstract: COPPER-CATALYZED CONJUGATE ADDITION OF AN ACETAL-CONTAINING GRIGNARD REAGENT. A METHOD FOR CYCLOPENTENE ANNULATION Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197909141 |
0.748 |
|
| 1978 |
Zask A, Helquist P. Palladium hydrides in organic synthesis. Reduction of aryl halides by sodium methoxide catalyzed by tetrakis(triphenylphosphine)palladium The Journal of Organic Chemistry. 43: 1619-1620. DOI: 10.1021/Jo00402A042 |
0.654 |
|
| 1978 |
Marfat A, Helquist P. Copper-catalyzed conjugate addition of an acetal-containing grignard reagent. A method for cyclopentene annulation. Tetrahedron Letters. 19: 4217-4220. DOI: 10.1016/S0040-4039(01)95185-8 |
0.746 |
|
| 1978 |
McGuirk PR, Marfat A, Helquist P. Determination of the configurations of trisubstituted olefins obtained from addition of alkylcopper complexes to acetylenes. Use of a lanthanide nmr shift reagent Tetrahedron Letters. 19: 2973-2976. DOI: 10.1016/S0040-4039(01)94915-9 |
0.729 |
|
| 1978 |
McGuirk PR, Marfat A, Helquist P. Stereoselective synthesis of homoallylic alcohols containingtrisubstituted olefinic double bonds Tetrahedron Letters. 19: 2465-2468. DOI: 10.1016/S0040-4039(01)94801-4 |
0.718 |
|
| 1978 |
Helquist P. Palladium hydrides in organic synthesis. Reduction of aryl bromides by sodium formate catalyzed by tetrakis(triphenylphosphine)palladium Tetrahedron Letters. 19: 1913-1914. DOI: 10.1016/S0040-4039(01)94707-0 |
0.405 |
|
| 1978 |
Marfat A, McGuirk PR, Helquist P. Addition of a methylcopper complex to acetylenes. Synthesis of trisubstituted olefins Tetrahedron Letters. 19: 1363-1366. DOI: 10.1016/S0040-4039(01)94546-0 |
0.751 |
|
| 1978 |
MCGUIRK PR, MARFAT A, HELQUIST P. ChemInform Abstract: DETERMINATION OF THE CONFIGURATIONS OF TRISUBSTITUTED OLEFINS OBTAINED FROM ADDITION OF ALKYLCOPPER COMPLEXES TO ACETYLENES. USE OF A LANTHANIDE NMR SHIFT REAGENT Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197847156 |
0.733 |
|
| 1978 |
MCGUIRK PR, MARFAT A, HELQUIST P. ChemInform Abstract: STEREOSELECTIVE SYNTHESIS OF HOMOALLYLIC ALCOHOLS CONTAINING TRISUBSTITUTED OLEFINIC DOUBLE BONDS Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197842094 |
0.724 |
|
| 1978 |
MARFAT A, MCGUIRK PR, HELQUIST P. ChemInform Abstract: ADDITION OF A METHYLCOPPER COMPLEX TO ACETYLENES. SYNTHESIS OF TRISUBSTITUTED OLEFINS Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197828124 |
0.754 |
|
| 1977 |
Marfat A, McGuirk PR, Kramer R, Helquist P. Conjugate addition of vinylcopper complexes derived from addition of alkylcopper complexes to acetylenes. A stereospecific synthesis of trisubstituted olefins Journal of the American Chemical Society. 99: 253-255. DOI: 10.1021/Ja00443A050 |
0.757 |
|
| 1977 |
Brewer PD, Tagat J, Hergrueter CA, Helquist P. Functionalized aryllithium intermediates. A synthesis of benzocyclobutenes Tetrahedron Letters. 18: 4573-4574. DOI: 10.1016/S0040-4039(01)83571-1 |
0.339 |
|
| 1975 |
Corey E, Helquist P. The synthesis of large-ring methylenecycloalkanes by the cyclization of allylic dibromides with nickel carbonyl Tetrahedron Letters. 16: 4091-4094. DOI: 10.1016/S0040-4039(00)91183-3 |
0.52 |
|
| 1973 |
SEMMELHACK MF, HELQUIST PM, GORZYNSKI JD. ChemInform Abstract: SYNTH. MIT NULLWERTIGEM NICKEL, KUPPLUNG VON ALKENYLHALOGENIDEN MIT BIS-(CYCLOOCTADIEN-(1,5))-NICKEL(0) Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197310236 |
0.656 |
|
| 1972 |
Semmelhack MF, Helquist PM, Gorzynski JD. Synthesis with zerovalent nickel. Coupling of alkenyl halides with bis(1,5-cyclooctadiene)nickel(0) [11] Journal of the American Chemical Society. 94: 9234-9236. DOI: 10.1021/Ja00781A048 |
0.685 |
|
| 1972 |
SEMMELHACK MF, HELQUIST PM, JONES LD. ChemInform Abstract: SYNTH. MIT NICKEL(0), KUPPLUNG VON ARYLHALOGENIDEN MIT BIS-(CYCLOOCTADIEN-(1,5))-NICKEL(0) Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197203225 |
0.656 |
|
| 1971 |
Semmelhack MF, Helquist PM, Jones LD. Synthesis with zerovalent nickel. Coupling of aryl halides with bis(1,5-cyclooctadiene)nickel(0) [10] Journal of the American Chemical Society. 93: 5908-5910. |
0.667 |
|
| 1969 |
Carlson RM, Helquist PM. A novel synthesis of 2-lithio derivatives of 2-substituted-1,3-dithianes. The addition of organolithium reagents to trimethylenedithio-carbene and to 2-methylene-1,3-dithiane Tetrahedron Letters. 10: 173-176. DOI: 10.1016/S0040-4039(01)87501-8 |
0.413 |
|
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