Steven R. Childers, Ph.D. - Publications

Affiliations: 
Physiology and Pharmacology Wake Forest University School of Medicine, Winston-Salem, NC, United States 
Area:
Signal Transduction
Website:
http://www.wakehealth.edu/PhysPharm/Faculty/Steven-R-Childers-PhD.htm

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pasternak GW, Childers SR, Pan YX. Emerging Insights into Mu Opioid Pharmacology. Handbook of Experimental Pharmacology. PMID 31598835 DOI: 10.1007/164_2019_270  0.429
2018 Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin T, Childers SR. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neuroscience Letters. PMID 29454035 DOI: 10.1016/J.Neulet.2018.02.026  0.424
2015 Martin TJ, Sexton T, Kim SA, Severino AL, Peters CM, Young LJ, Childers SR. Regional Differences in Mu and Kappa Opioid Receptor G-protein Activation in Brain in Male and Female Prairie Voles. Neuroscience. PMID 26523979 DOI: 10.1016/J.Neuroscience.2015.10.047  0.454
2015 McIntosh S, Sexton T, Pattison LP, Childers SR, Hemby SE. Increased Sensitivity to Cocaine Self-Administration in HIV-1 Transgenic Rats is Associated with Changes in Striatal Dopamine Transporter Binding. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 25749646 DOI: 10.1007/S11481-015-9594-0  0.719
2015 Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC. Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Neuropharmacology. 95: 492-502. PMID 25724082 DOI: 10.1016/J.Neuropharm.2015.02.021  0.461
2014 Pattison LP, McIntosh S, Sexton T, Childers SR, Hemby SE. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse (New York, N.Y.). 68: 437-44. PMID 24916769 DOI: 10.1002/Syn.21755  0.731
2013 Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, Bornmann WG, Eshleman AJ, Janowsky A, Simon ER, Reith ME, Alper K. Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation. Plos One. 8: e77262. PMID 24204784 DOI: 10.1371/Journal.Pone.0077262  0.428
2013 Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC. Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems. Journal of Neurochemistry. 124: 808-20. PMID 23286559 DOI: 10.1111/Jnc.12139  0.375
2012 Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behavioural Brain Research. 227: 258-64. PMID 22085876 DOI: 10.1016/J.Bbr.2011.10.048  0.369
2011 Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. British Journal of Pharmacology. 163: 1329-43. PMID 21545414 DOI: 10.1111/J.1476-5381.2011.01364.X  0.416
2011 Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR. Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury Anesthesiology. 114: 633-642. PMID 21293255 DOI: 10.1097/Aln.0B013E318209Aba7  0.442
2009 Manning JR, Sexton T, Childers SR, Davies HM. 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 58-61. PMID 19038547 DOI: 10.1016/J.Bmcl.2008.11.022  0.383
2009 Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DC, Bonin KD, Budygin EA. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1174-84. PMID 18923398 DOI: 10.1038/Npp.2008.186  0.408
2008 Murthy V, Martin TJ, Kim S, Davies HM, Childers SR. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 326: 587-95. PMID 18492949 DOI: 10.1124/Jpet.108.138842  0.703
2008 Childers SR. Activation of g-proteins in brain by endogenous and exogenous cannabinoids Drug Addiction: From Basic Research to Therapy. 719-729. DOI: 10.1208/Aapsj080113  0.508
2007 Murthy V, Davies HM, Hedley SJ, Childers SR. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical Pharmacology. 74: 336-44. PMID 17540345 DOI: 10.1016/J.Bcp.2007.04.019  0.682
2007 Clayton BA, Hayashida KI, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism Anesthesiology. 106: 1019-1025. PMID 17457135 DOI: 10.1097/01.Anes.0000265163.22007.6D  0.384
2007 Martin TJ, Kahn WR, Xiao R, Childers SR. Differential regional effects of methadone maintenance compared to heroin dependence on μ-opioid receptor desensitization in rat brain Synapse. 61: 176-184. PMID 17152089 DOI: 10.1002/Syn.20355  0.505
2006 Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity Neuroreport. 17: 1619-1622. PMID 17001280 DOI: 10.1097/01.Wnr.0000239949.37825.E9  0.33
2005 Lapa GB, Byrd GD, Lapa AA, Budygin EA, Childers SR, Jones SR, Harp JJ. The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines. Bioorganic & Medicinal Chemistry Letters. 15: 4915-8. PMID 16165350 DOI: 10.1016/J.Bmcl.2005.08.028  0.35
2005 Maher CE, Martin TJ, Childers SR. Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration Life Sciences. 77: 1140-1154. PMID 15890372 DOI: 10.1016/J.Lfs.2005.03.004  0.801
2005 Childers SR, Li X, Xiao R, Eisenach JC. Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain Journal of Neurochemistry. 93: 715-723. PMID 15836630 DOI: 10.1111/J.1471-4159.2005.03044.X  0.435
2005 Bantel C, Eisenach JC, Duflo F, Tobin JR, Childers SR. Spinal nerve ligation increases α2-adrenergic receptor G-protein coupling in the spinal cord Brain Research. 1038: 76-82. PMID 15748875 DOI: 10.1016/J.Brainres.2005.01.016  0.444
2005 O'Connor KA, Porrino LJ, Davies HM, Childers SR. Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade. The Journal of Pharmacology and Experimental Therapeutics. 313: 510-7. PMID 15644432 DOI: 10.1124/Jpet.104.078451  0.549
2005 O'Connor KA, Gregg TC, Davies HM, Childers SR. Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain. Neuropharmacology. 48: 62-71. PMID 15617728 DOI: 10.1016/J.Neuropharm.2004.08.014  0.547
2004 Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 47: 345-58. PMID 15464149 DOI: 10.1016/J.Neuropharm.2004.07.030  0.408
2004 Breivogel CS, Walker JM, Huang SM, Roy MB, Childers SR. Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. Neuropharmacology. 47: 81-91. PMID 15165836 DOI: 10.1016/J.Neuropharm.2004.02.017  0.411
2004 Li X, Bantel C, Conklin D, Childers SR, Eisenach JC. Repeated Dosing with Oral Allosteric Modulator of Adenosine A1 Receptor Produces Tolerance in Rats with Neuropathic Pain Anesthesiology. 100: 956-961. PMID 15087633 DOI: 10.1097/00000542-200404000-00028  0.366
2004 Davies HM, Hopper DW, Hansen T, Liu Q, Childers SR. Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites. Bioorganic & Medicinal Chemistry Letters. 14: 1799-802. PMID 15026075 DOI: 10.1016/J.Bmcl.2003.12.097  0.418
2003 Sim-Selley LJ, Vogt LJ, Childers SR, Vogt BA. Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex. Neuropharmacology. 45: 220-30. PMID 12842128 DOI: 10.1016/S0028-3908(03)00155-2  0.477
2002 Sim-Selley LJ, Vogt LJ, Vogt BA, Childers SR. Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex. Life Sciences. 71: 2217-26. PMID 12215369 DOI: 10.1016/S0024-3205(02)02017-9  0.496
2002 Bantel C, Childers SR, Eisenach JC. Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury Anesthesiology. 96: 1443-1449. PMID 12170058 DOI: 10.1097/00000542-200206000-00025  0.387
2002 Davies HM, Ren P, Kong NX, Sexton T, Childers SR. Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. Bioorganic & Medicinal Chemistry Letters. 12: 845-7. PMID 11958976 DOI: 10.1016/S0960-894X(02)00048-3  0.354
2002 Bantel C, Tobin JR, Li X, Childers SR, Chen SR, Eisenach JC. Intrathecal adenosine following spinal nerve ligation in rat: Short residence time in cerebrospinal fluid and no change in A 1 receptor binding Anesthesiology. 96: 103-108. PMID 11753009 DOI: 10.1097/00000542-200201000-00022  0.344
2001 Sim-Selley LJ, Childers SR. Neuroanatomical localization of receptor-activated G proteins in brain Methods in Enzymology. 344: 42-58. PMID 11771400 DOI: 10.1016/S0076-6879(02)44704-0  0.38
2001 Vogt LJ, Sim-Selley LJ, Childers SR, Wiley RG, Vogt BA. Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex. The Journal of Pharmacology and Experimental Therapeutics. 299: 840-8. PMID 11714867  0.404
2001 Selley DE, Cao CC, Sexton T, Schwegel JA, Martin TJ, Childers SR. mu Opioid receptor-mediated G-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine. Biochemical Pharmacology. 62: 447-55. PMID 11448454 DOI: 10.1016/S0006-2952(01)00689-X  0.478
2001 Davies HM, Gilliatt V, Kuhn LA, Saikali E, Ren P, Hammond PS, Sexton T, Childers SR. Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites. Journal of Medicinal Chemistry. 44: 1509-15. PMID 11334561 DOI: 10.1021/Jm000363+  0.399
2001 Daunais JB, Letchworth SR, Sim-Selley LJ, Smith HR, Childers SR, Porrino LJ. Functional and anatomical localization of mu opioid receptors in the striatum, amygdala, and extended amygdala of the nonhuman primate. The Journal of Comparative Neurology. 433: 471-85. PMID 11304712 DOI: 10.1002/Cne.1154  0.517
2001 Maher CE, Eisenach JC, Pan HL, Xiao R, Childers SR. Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord. Brain Research. 895: 1-8. PMID 11259753 DOI: 10.1016/S0006-8993(00)03093-6  0.766
2001 Davies HM, Ren P, Kong N, Sexton T, Childers SR. Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl. Bioorganic & Medicinal Chemistry Letters. 11: 487-9. PMID 11229754 DOI: 10.1016/S0960-894X(00)00701-0  0.368
2000 Breivogel CS, Childers SR. Cannabinoid agonist signal transduction in rat brain: Comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition Journal of Pharmacology and Experimental Therapeutics. 295: 328-336. PMID 10991998  0.487
2000 Selley DE, Cao CC, Liu Q, Childers SR. Effects of sodium on agonist efficacy for G-protein activation in μ-opioid receptor-transfected CHO cells and rat thalamus British Journal of Pharmacology. 130: 987-996. PMID 10882382 DOI: 10.1038/Sj.Bjp.0703382  0.549
2000 Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, Davies HM. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). 37: 109-17. PMID 10881032 DOI: 10.1002/1098-2396(200008)37:2<109::Aid-Syn5>3.0.Co;2-3  0.364
2000 Sim-Selley LJ, Selley DE, Vogt LJ, Childers SR, Martin TJ. Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4555-62. PMID 10844025 DOI: 10.1523/Jneurosci.20-12-04555.2000  0.562
2000 Letchworth SR, Smith HR, Porrino LJ, Bennett BA, Davies HM, Sexton T, Childers SR. Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 293: 686-96. PMID 10773045  0.361
2000 Maher CE, Selley DE, Childers SR. Relationship of mu opioid receptor binding to activation of G-proteins in specific rat brain regions Biochemical Pharmacology. 59: 1395-1401. PMID 10751548 DOI: 10.1016/S0006-2952(00)00272-0  0.802
2000 Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumours British Journal of Cancer. 82: 1223-1232. PMID 10735510 DOI: 10.1054/Bjoc.1999.1067  0.305
2000 Sim-Selley LJ, Vogt LJ, Xiao R, Childers SR, Selley DE. Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone. European Journal of Pharmacology. 389: 147-53. PMID 10688978 DOI: 10.1016/S0014-2999(99)00875-4  0.415
2000 Moore RJ, Xiao R, Sim-Selley LJ, Childers SR. Agonist-stimulated [35S]GTPγS binding in brain - Modulation by endogenous adenosine Neuropharmacology. 39: 282-289. PMID 10670423 DOI: 10.1016/S0028-3908(99)00112-4  0.535
2000 Sim-Selley LJ, Xiao R, Childers SR. Anatomical distribution of sodium-dependent [3H]naloxone binding sites in rat brain Synapse. 35: 256-264. PMID 10657035 DOI: 10.1002/(Sici)1098-2396(20000315)35:4<256::Aid-Syn3>3.0.Co;2-7  0.524
1999 Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Vogt LJ, Sim-Selley LJ. Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain. Journal of Neurochemistry. 73: 2447-59. PMID 10582605 DOI: 10.1046/J.1471-4159.1999.0732447.X  0.563
1999 Sim-Selley LJ, Daunais JB, Porrino LJ, Childers SR. Mu and kappa1 opioid-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in cynomolgus monkey brain. Neuroscience. 94: 651-62. PMID 10579225 DOI: 10.1016/S0306-4522(99)00344-9  0.573
1999 Al-Nabulsi I, Mach RH, Wang LM, Wallen CA, Keng PC, Sten K, Childers SR, Wheeler KT. Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells British Journal of Cancer. 81: 925-933. PMID 10576647 DOI: 10.1038/Sj.Bjc.6690789  0.322
1999 Letchworth SR, Sexton T, Childers SR, Vrana KE, Vaughan RA, Davies HM, Porrino LJ. Regulation of rat dopamine transporter mRNA and protein by chronic cocaine administration. Journal of Neurochemistry. 73: 1982-9. PMID 10537056  0.376
1999 Roberts DC, Phelan R, Hodges LM, Hodges MM, Bennett B, Childers S, Davies H. Self-administration of cocaine analogs by rats. Psychopharmacology. 144: 389-97. PMID 10435412 DOI: 10.1007/S002130051022  0.304
1999 Mach RH, Wu L, West T, Whirrett BR, Childers SR. The analgesic tropane analogue (±)-SM 21 has a high affinity for σ2 receptors Life Sciences. 64: PL131-PL137. PMID 10096443 DOI: 10.1016/S0024-3205(99)00014-4  0.411
1998 Breivogel CS, Childers SR. The functional neuroanatomy of brain Cannabinoid receptors Neurobiology of Disease. 5: 417-431. PMID 9974175 DOI: 10.1006/Nbdi.1998.0229  0.399
1998 Zhuang S, Kittler J, Grigorenko EV, Kirby MT, Sim LJ, Hampson RE, Childers SR, Deadwyler SA. Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions. Brain Research. Molecular Brain Research. 62: 141-9. PMID 9813289 DOI: 10.1016/S0169-328X(98)00232-0  0.35
1998 Childers SR, Breivogel CS. Cannabis and endogenous cannabinoid systems Drug and Alcohol Dependence. 51: 173-187. PMID 9716939 DOI: 10.1016/S0376-8716(98)00075-1  0.428
1998 Childers SR, Xiao R, Vogt L, Sim LJ. Lack of evidence of κ2-selective activation of G-proteins. kappa; opioid receptor stimulation of [35S] GTPγS binding in guinea pig brain Biochemical Pharmacology. 56: 113-120. PMID 9698095 DOI: 10.1016/S0006-2952(98)00123-3  0.568
1998 Bennett BA, Hollingsworth CK, Martin RS, Childers SR, Ehrenkaufer RE, Porrino LJ, Davies HM. Prolonged dopamine and serotonin transporter inhibition after exposure to tropanes. Neuropharmacology. 37: 123-30. PMID 9680265 DOI: 10.1016/S0028-3908(97)00194-9  0.426
1998 Breivogel CS, Selley DE, Childers SR. Cannabinoid receptor agonist efficacy for stimulating [35S]GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity Journal of Biological Chemistry. 273: 16865-16873. PMID 9642247 DOI: 10.1074/Jbc.273.27.16865  0.526
1998 Huang Y, Hammond PS, Whirrett BR, Kuhner RJ, Wu L, Childers SR, Mach RH. Synthesis and quantitative structure-activity relationships of N-(1- benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective σ1 receptor ligands Journal of Medicinal Chemistry. 41: 2361-2370. PMID 9632369 DOI: 10.1021/Jm980032L  0.435
1998 Daunais JB, Hart SL, Smith HR, Letchworth SR, Davies HM, Sexton T, Bennett BA, Childers SR, Porrino LJ. Long-acting blockade of biogenic amine transporters in rat brain by administration of the potent novel tropane 2beta-propanoyl-3beta-(2-Naphthyl)-tropane. The Journal of Pharmacology and Experimental Therapeutics. 285: 1246-54. PMID 9618429  0.411
1998 Selley DE, Liu Q, Childers SR. Signal transduction correlates of Mu opioid agonist intrinsic efficacy: Receptor-stimulated [35S]GTPγS binding in mMOR-CHO cells and rat thalamus Journal of Pharmacology and Experimental Therapeutics. 285: 496-505. PMID 9580589  0.481
1998 Sim LJ, Liu Q, Childers SR, Selley DE. Endomorphin-stimulated [35S]GTPγs binding in rat brain: Evidence for partial agonist activity at μ-opioid receptors Journal of Neurochemistry. 70: 1567-1576. PMID 9523574 DOI: 10.1046/J.1471-4159.1998.70041567.X  0.574
1998 Selley DE, Breivogel CS, Childers SR. Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin- related NG108-15 cells Journal of Receptor and Signal Transduction Research. 18: 25-50. PMID 9493566 DOI: 10.3109/10799899809039163  0.469
1998 Stark S, Pacheco MA, Childers SR. Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells. Cellular and Molecular Neurobiology. 17: 483-93. PMID 9353590 DOI: 10.1023/A:1026306804802  0.378
1997 Childers SR. Opioid receptors: Pinning down the opiate targets Current Biology. 7: R695-R697. PMID 9382783 DOI: 10.1016/S0960-9822(06)00358-7  0.404
1997 Sim LJ, Childers SR. Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5,-O-(γ-thio)-triphosphate binding in guinea pig brain Journal of Comparative Neurology. 386: 562-572. PMID 9378852 DOI: 10.1002/(Sici)1096-9861(19971006)386:4<562::Aid-Cne4>3.0.Co;2-0  0.555
1997 Martin TJ, Sim LJ, Selley DE, DeMontis MG, Childers SR. Effects of intracerebroventricular administration of β-funaltrexamine on DAMGO-stimulated [35S]GTP-γ-S binding in rat brain sections Synapse. 27: 177-182. PMID 9329153 DOI: 10.1002/(Sici)1098-2396(199711)27:3<177::Aid-Syn3>3.0.Co;2-A  0.394
1997 Breivogel CS, Sim LJ, Childers SR. Regional differences in cannabinoid receptor/G-protein coupling in rat brain Journal of Pharmacology and Experimental Therapeutics. 282: 1632-1642. PMID 9316881  0.447
1997 Sim LJ, Xiao R, Childers SR. In vitro autoradiographic localization of 5-HT(1A) receptor-activated G- proteins in the rat brain Brain Research Bulletin. 44: 39-45. PMID 9288830 DOI: 10.1016/S0361-9230(97)00061-0  0.509
1997 Sim LJ, Selley DE, Childers SR. Autoradiographic visualization in brain of receptor-G protein coupling using [35S]GTP gamma S binding. Methods in Molecular Biology (Clifton, N.J.). 83: 117-132. PMID 9210141 DOI: 10.1385/0-89603-495-X:117  0.429
1997 Breivogel CS, Selley DE, Childers SR. Acute and chronic effects of opioids on δ and μ receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes Journal of Neurochemistry. 68: 1462-1472. PMID 9084416 DOI: 10.1046/J.1471-4159.1997.68041462.X  0.546
1997 Selley DE, Nestler EJ, Breivogel CS, Childers SR. Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: Decrease in activity after chronic morphine treatment Brain Research. 746: 10-18. PMID 9037478 DOI: 10.1016/S0006-8993(96)01125-0  0.492
1997 Selley DE, Sim LJ, Xiao R, Liu Q, Childers SR. μ-Opioid receptor-stimulated guanosine-5'-O-(γ-thio)-triphosphate binding in rat thalamus and cultured cell lines: Signal transduction mechanisms underlying agonist efficacy Molecular Pharmacology. 51: 87-96. PMID 9016350 DOI: 10.1124/Mol.51.1.87  0.532
1996 Sim LJ, Hampson RE, Deadwyler SA, Childers SR. Effects of chronic treatment with delta9-tetrahydrocannabinol on cannabinoid-stimulated [35S]GTPgammaS autoradiography in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 8057-66. PMID 8987831  0.434
1996 Sim LJ, Selley DE, Xiao R, Childers SR. Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum European Journal of Pharmacology. 307: 97-105. PMID 8831110 DOI: 10.1016/0014-2999(96)00211-7  0.572
1996 Sim LJ, Selley DE, Dworkin SI, Childers SR. Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2684-92. PMID 8786444 DOI: 10.1523/Jneurosci.16-08-02684.1996  0.506
1996 Childers SR, Deadwyler SA. Role of cyclic AMP in the actions of cannabinoid receptors. Biochemical Pharmacology. 52: 819-27. PMID 8781498 DOI: 10.1016/0006-2952(96)00419-4  0.401
1996 Selley DE, Stark S, Sim LJ, Childers SR. Cannabinoid receptor stimulation of guanosine-5'-O-(3- [35S]thio)triphosphate binding in rat brain membranes Life Sciences. 59: 659-668. PMID 8761016 DOI: 10.1016/0024-3205(96)00347-5  0.532
1996 Sim LJ, Xiao R, Childers SR. Identification of opioid receptor-like (ORL1) peptide-stimulated [35S]GTPγS binding in rat brain Neuroreport. 7: 729-733. PMID 8733732 DOI: 10.1097/00001756-199602290-00012  0.486
1996 Davies HM, Kuhn LA, Thornley C, Matasi JJ, Sexton T, Childers SR. Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site. Journal of Medicinal Chemistry. 39: 2554-8. PMID 8691453 DOI: 10.1021/Jm9600508  0.354
1996 Sim LJ, Hampson RE, Deadwyler SA, Childers SR. Effects of Chronic Treatment with Δ9-Tetrahydrocannabinol on Cannabinoid-Stimulated [35S]GTPγS Autoradiography in Rat Brain The Journal of Neuroscience. 16: 8057-8066. DOI: 10.1523/Jneurosci.16-24-08057.1996  0.512
1995 Bennett BA, Wichems CH, Hollingsworth CK, Davies HM, Thornley C, Sexton T, Childers SR. Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 272: 1176-86. PMID 7891330  0.311
1995 Hampson RE, Evans GJ, Mu J, Zhuang SY, King VC, Childers SR, Deadwyler SA. Role of cyclic AMP dependent protein kinase in cannabinoid receptor modulation of potassium "A-current" in cultured rat hippocampal neurons. Life Sciences. 56: 2081-8. PMID 7776835 DOI: 10.1016/0024-3205(95)00192-9  0.335
1995 Efange SMN, Mach RH, Smith CR, Khare AB, Foulon C, Akella SK, Childers SR, Parsons SM. Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor Biochemical Pharmacology. 49: 791-797. PMID 7702637 DOI: 10.1016/0006-2952(94)00541-S  0.392
1995 Sim LJ, Selley DE, Childers SR. In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[γ-[35S]thio]-triphosphate binding Proceedings of the National Academy of Sciences of the United States of America. 92: 7242-7246. PMID 7638174 DOI: 10.1073/Pnas.92.16.7242  0.568
1995 Mach RH, Smith CR, Childers SR. Ibogaine possesses a selective affinity for σ2 receptors Life Sciences. 57: PL57-PL62. PMID 7603301 DOI: 10.1016/0024-3205(95)00301-L  0.455
1995 Kluttz BW, Vrana KE, Dworkin SI, Childers SR. Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain. Brain Research. Molecular Brain Research. 32: 313-20. PMID 7500843 DOI: 10.1016/0169-328X(95)00100-7  0.422
1995 Sim LJ, Xiao R, Childers SR. IN VITRO AUTORADIOGRAPHY OF OPIOID RECEPTOR-ACTIVATED G-PROTEINS USING [35S]GTPγS BINDING Analgesia. 1: 738-741. DOI: 10.3727/107156995819563203  0.426
1995 Selley DE, Breivogel CS, Childers SR. MECHANISMS OF LOW pH PRETREATMENT-INDUCED INCREASE IN OPIOID AGONIST EFFICACY: [35S]GTPγS BINDING STUDIES Analgesia. 1: 715-718. DOI: 10.3727/107156995819563113  0.32
1994 Porrino LJ, Migliarese K, Davies HM, Saikali E, Childers SR. Behavioral effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-toluyl)-tropane (PTT). Life Sciences. 54: PL511-7. PMID 8208059 DOI: 10.1016/0024-3205(94)00725-X  0.445
1994 Davies HM, Saikali E, Huby NJ, Gilliatt VJ, Matasi JJ, Sexton T, Childers SR. Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex. Journal of Medicinal Chemistry. 37: 1262-8. PMID 8176704 DOI: 10.1021/Jm00035A005  0.383
1994 Pacheco MA, Ward SJ, Childers SR. Differential requirements of sodium for coupling of cannabinoid receptors to adenylyl cyclase in rat brain membranes. Journal of Neurochemistry. 62: 1773-82. PMID 8158127 DOI: 10.1046/J.1471-4159.1994.62051773.X  0.502
1994 Childers SR, Sexton T, Roy MB. Effects of anandamide on cannabinoid receptors in rat brain membranes. Biochemical Pharmacology. 47: 711-5. PMID 8129747 DOI: 10.1016/0006-2952(94)90134-1  0.505
1994 Uhl GR, Childers S, Pasternak G. An opiate-receptor gene family reunion. Trends in Neurosciences. 17: 89-93. PMID 7515530 DOI: 10.1016/0166-2236(94)90110-4  0.3
1994 Sim LJ, Porrino L, Childers SR. Novel distribution of sodium-dependent [3H]naloxone binding sites in rat brain Regulatory Peptides. 54: 275-276. DOI: 10.1016/0167-0115(94)90496-0  0.477
1994 Selley DE, Breivogel CS, Childers SR. Opioid inhibition of adenylyl cyclase remaining after pertussis toxin treatment of NG108-15 cells: Possible involvement of tightly bound GTP. Regulatory Peptides. 54: 265-266. DOI: 10.1016/0167-0115(94)90491-X  0.447
1994 Childers SR, Kluttz B. Molecular mechanisms of opioid tolerance Regulatory Peptides. 54: 61-62. DOI: 10.1016/0167-0115(94)90389-1  0.316
1993 Davies HM, Saikali E, Sexton T, Childers SR. Novel 2-substituted cocaine analogs: binding properties at dopamine transport sites in rat striatum. European Journal of Pharmacology. 244: 93-7. PMID 8420793 DOI: 10.1016/0922-4106(93)90063-F  0.469
1993 Pacheco MA, Ward SJ, Childers SR. Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. Brain Research. 603: 102-10. PMID 8384043 DOI: 10.1016/0006-8993(93)91304-B  0.443
1993 Konkoy CS, Childers SR. Relationship between kappa1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes Biochemical Pharmacology. 45: 207-216. PMID 8381004 DOI: 10.1016/0006-2952(93)90394-C  0.527
1993 Childers SR, Fleming LM, Selley DE, McNutt RW, Chang KJ. BW373U86: A nonpeptidic δ-opioid agonist with novel receptor-G protein- mediated actions in rat brain membranes and neuroblastoma cells Molecular Pharmacology. 44: 827-834. PMID 8232233  0.433
1993 Selley DE, Breivogel CS, Childers SR. Modification of G protein-coupled functions by low-pH pretreatment of membranes from NG108-15 cells: Increase in opioid agonist efficacy by decreased inactivation of G proteins Molecular Pharmacology. 44: 731-741. PMID 8232223  0.348
1993 Childers SR, Pacheco MA, Bennett BA, Edwards TA, Hampson RE, Mu J, Deadwyler SA. Cannabinoid receptors: G-protein-mediated signal transduction mechanisms. Biochemical Society Symposium. 59: 27-50. PMID 8192687  0.311
1992 Nijssen PC, Sexton T, Childers SR. Opioid-inhibited adenylyl cyclase in rat brain membranes: lack of correlation with high-affinity opioid receptor binding sites. Journal of Neurochemistry. 59: 2251-62. PMID 1331327 DOI: 10.1111/J.1471-4159.1992.Tb10118.X  0.531
1992 Childers SR, Fleming L, Konkoy C, Marckel D, Pacheco M, Sexton T, Ward S. Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain. Annals of the New York Academy of Sciences. 654: 33-51. PMID 1321574 DOI: 10.1111/J.1749-6632.1992.Tb25954.X  0.489
1992 Fleming LM, Ponjee G, Childers SR. Inhibition of protein phosphorylation by opioid-inhibited adenylyl cyclase in rat brain membranes Journal of Pharmacology and Experimental Therapeutics. 260: 1416-1424. PMID 1312171  0.316
1991 Pacheco M, Childers SR, Arnold R, Casiano F, Ward SJ. Aminoalkylindoles: actions on specific G-protein-linked receptors. The Journal of Pharmacology and Experimental Therapeutics. 257: 170-83. PMID 1902257  0.336
1991 Childers SR. Opioid receptor-coupled second messenger systems Life Sciences. 48: 1991-2003. PMID 1851914 DOI: 10.1016/0024-3205(91)90154-4  0.473
1989 Konkoy CS, Childers SR. Dynorphin-selective inhibition of adenylyl cyclase in guinea pig cerebellum membranes Molecular Pharmacology. 36: 627-633. PMID 2572962  0.378
1988 Childers SR. Opiate-inhibited adenylate cyclase in rat brain membranes depleted of G(s)-stimulated adenylate cyclase Journal of Neurochemistry. 50: 543-553. PMID 2826699  0.394
1987 Nijssen PCG, Childers SR. Characteristics of sodium-induced increase in opiate antagonist binding sites in rat brain membranes European Journal of Pharmacology. 135: 355-364. PMID 3034634 DOI: 10.1016/0014-2999(87)90685-6  0.402
1985 Lewis RE, Childers SR, Phillips MI. [125I]Tyr-bradykinin binding in primary rat brain cultures. Brain Research. 346: 263-72. PMID 4052779 DOI: 10.1016/0006-8993(85)90859-5  0.359
1984 Childers SR, LaRiviere G. Modification of guanine nucleotide-regulatory components in brain membranes. II. Relationship of guanosine 5'-triphosphate effects on opiate receptor binding and coupling receptors with adenylate cyclase Journal of Neuroscience. 4: 2764-2771. PMID 6094742  0.356
1984 Lambert SM, Childers SR. Modification of guanine nucleotide-regulatory components in brain membranes. I. Changes in guanosine 5'-triphosphate regulation of opiate receptor-binding sites Journal of Neuroscience. 4: 2755-2763. PMID 6094741  0.391
1984 Childers SR. Interaction of opiate receptor binding sites and guanine nucleotide regulatory sites: Selective protection from N-ethylmaleimide Journal of Pharmacology and Experimental Therapeutics. 230: 684-691. PMID 6088761  0.413
1984 Childers SR, Jackson JL. pH selectivity of N-ethylmaleimide reactions with opiate receptor complexes in rat brain membranes. Journal of Neurochemistry. 43: 1163-70. PMID 6088695  0.321
1983 Childers SR, Lambert SM, La Riviere G. Selective alterations in guanine nucleotide regulation of opiate receptor binding and coupling with adenylate cyclase Life Sciences. 33: 215-218. PMID 6319864 DOI: 10.1016/0024-3205(83)90481-2  0.358
1982 Childers SR, Pasternak GW. Naloxazone, a novel opiate antagonist: Irreversible blockade of rat brain opiate receptors in vitro Cellular and Molecular Neurobiology. 2: 93-103. DOI: 10.1007/Bf00711075  0.459
1981 Dunn AJ, Childers SR, Kramarcy NR, Villiger JW. ACTH-induced grooming involves high-affinity opiate receptors Behavioral and Neural Biology. 31: 105-109. PMID 6272677 DOI: 10.1016/S0163-1047(81)91178-X  0.356
1980 Childers SR, Snyder SH. Characterization of [3H]guanine nucleotide binding sites in brain membranes Journal of Neurochemistry. 35: 183-192. PMID 6256476 DOI: 10.1111/J.1471-4159.1980.Tb12505.X  0.348
1980 Pasternak GW, Childers SR, Snyder SH. Opiate analgesia: Evidence for mediation by a subpopulation of opiate receptors Science. 208: 514-516. PMID 6245448 DOI: 10.1097/00132586-198108000-00009  0.457
1980 Childers SR, Synder SH. Differential regulation by guanine nucleotides of opiate agonist and antagonist receptor interactions Journal of Neurochemistry. 34: 583-593. PMID 6243694 DOI: 10.1111/J.1471-4159.1980.Tb11184.X  0.415
1980 Pasternak GW, Childers SR, Snyder SH. Naloxazone, a long-acting opiate antagonist: Effects on analgesia in intact animals and on opiate receptor binding in vitro Journal of Pharmacology and Experimental Therapeutics. 214: 455-462. PMID 6105201  0.414
1979 Childers SR, Creese I, Snowman AM, Synder SH. Opiate receptor binding affected differentially by opiates and opioid peptides. European Journal of Pharmacology. 55: 11-8. PMID 220062 DOI: 10.1016/0014-2999(79)90142-0  0.392
1978 Childers SR, Snyder SH. Guanine nucleotides differentiate agonist and antagonist interactions with opiate receptors Life Sciences. 23: 759-761. PMID 211364 DOI: 10.1016/0024-3205(78)90077-2  0.406
1978 Simantov R, Childers SR, Snyder SH. The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptide European Journal of Pharmacology. 47: 319-331. PMID 204498 DOI: 10.1016/0014-2999(78)90240-6  0.338
1977 Childers SR, Simantov R, Snyder SH. Enkephalin: Radioimmunoassay and radioreceptor assay in morphine dependent rats European Journal of Pharmacology. 46: 289-293. PMID 563332 DOI: 10.1016/0014-2999(77)90346-6  0.316
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