Andrew Bennet, Ph.D. - Publications

Affiliations: 
Chemistry Simon Fraser University, Burnaby, British Columbia, Canada 
Area:
Bioorganic chemistry, carbohydrate chemistry, physical organic chemistry
Website:
https://www.sfu.ca/chemistry/people/profiles/bennet.html

31/65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ren W, Farren-Dai M, Sannikova N, Świderek K, Wang Y, Akintola O, Britton R, Moliner V, Bennet AJ. Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design. Chemical Science. 11: 10488-10495. PMID 34094307 DOI: 10.1039/d0sc04401f  0.315
2020 Nejatie A, Akintola O, Steves E, Shamsi Kazem Abadi S, Moore MM, Bennet AJ. Structurally homologous sialidases exhibit a commonality in reactivity: Glycoside hydrolase-catalyzed hydrolysis of Kdn-thioglycosides. Bioorganic Chemistry. 104484. PMID 33268005 DOI: 10.1016/j.bioorg.2020.104484  0.394
2020 Sobala LF, Speciale G, Zhu S, Raich L, Sannikova N, Thompson AJ, Hakki Z, Lu D, Shamsi Kazem Abadi S, Lewis AR, Rojas-Cervellera V, Bernardo-Seisdedos G, Zhang Y, Millet O, Jiménez-Barbero J, ... Bennet AJ, et al. An Epoxide Intermediate in Glycosidase Catalysis. Acs Central Science. 6: 760-770. PMID 32490192 DOI: 10.1021/Acscentsci.0C00111  0.414
2020 Adabala PJP, Shamsi Kazem Abadi S, Akintola O, Bhosale S, Bennet AJ. Conformationally Controlled Reactivity of Carbasugars Uncovers the Choreography of Glycoside Hydrolase Catalysis. The Journal of Organic Chemistry. 85: 3336-3348. PMID 31994882 DOI: 10.1021/acs.joc.9b03152  0.363
2019 Abadi SSK, Deen MC, Watson JN, Shidmoossavee FS, Bennet AJ. Directed Evolution of a Remarkably Efficient Kdnase from a Bacterial Neuraminidase. Glycobiology. PMID 31804700 DOI: 10.1093/glycob/cwz099  0.319
2018 Sannikova N, Gerak CAN, Shidmoossavee FS, King DT, Shamsi Kazem Abadi S, Lewis AR, Bennet AJ. Both Chemical and Non-Chemical Steps Limit the Catalytic Efficiency of Family 4 Glycoside Hydrolases. Biochemistry. PMID 29630821 DOI: 10.1021/acs.biochem.8b00117  0.43
2016 Speciale G, Farren-Dai M, Shidmoossavee FS, Williams SJ, Bennet AJ. C2-Oxyanion neighboring group participation: Transition state structure for the hydroxide-promoted hydrolysis of 4-nitrophenyl α-D-mannopyranoside. Journal of the American Chemical Society. PMID 27723312 DOI: 10.1021/Jacs.6B07935  0.42
2014 Chan J, Sannikova N, Tang A, Bennet AJ. Transition-state structure for the quintessential SN2 reaction of a carbohydrate: reaction of α-glucopyranosyl fluoride with azide ion in water. Journal of the American Chemical Society. 136: 12225-8. PMID 25121958 DOI: 10.1021/ja506092h  0.52
2014 Cheng LL, Shidmoossavee FS, Bennet AJ. Neuraminidase substrate promiscuity permits a mutant Micromonospora viridifaciens enzyme to synthesize artificial carbohydrates. Biochemistry. 53: 3982-89. PMID 24870444 DOI: 10.1021/bi500203p  0.351
2013 Yeung JH, Telford JC, Shidmoossavee FS, Bennet AJ, Taylor GL, Moore MM. Kinetic and structural evaluation of selected active site mutants of the Aspergillus fumigatus KDNase (sialidase). Biochemistry. 52: 9177-86. PMID 24295366 DOI: 10.1021/Bi401166F  0.327
2012 Bennet AJ. Kinetic isotope effects for studying post-translational modifying enzymes. Current Opinion in Chemical Biology. 16: 472-8. PMID 23146439 DOI: 10.1016/j.cbpa.2012.10.024  0.346
2012 Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase. The Journal of Biological Chemistry. 287: 28882-97. PMID 22692202 DOI: 10.1074/Jbc.M112.363721  0.403
2012 Chan J, Lewis AR, Indurugalla D, Schur M, Wakarchuk W, Bennet AJ. Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues. Journal of the American Chemical Society. 134: 3748-57. PMID 22296330 DOI: 10.1021/Ja208564Y  0.563
2012 Chan J, Tang A, Bennet AJ. A stepwise solvent-promoted SNi reaction of α-D-glucopyranosyl fluoride: mechanistic implications for retaining glycosyltransferases. Journal of the American Chemical Society. 134: 1212-20. PMID 22148388 DOI: 10.1021/Ja209339J  0.546
2012 Chan J, Watson JN, Lu A, Cerda VC, Borgford TJ, Bennet AJ. Bacterial and viral sialidases: contribution of the conserved active site glutamate to catalysis. Biochemistry. 51: 433-41. PMID 22133027 DOI: 10.1021/Bi201019N  0.488
2011 Chan J, Sandhu G, Bennet AJ. A mechanistic study of sialic acid mutarotation: implications for mutarotase enzymes. Organic & Biomolecular Chemistry. 9: 4818-22. PMID 21584336 DOI: 10.1039/c1ob05079f  0.541
2011 Chakladar S, Cheng L, Choi M, Liu J, Bennet AJ. Mechanistic evaluation of MelA α-galactosidase from Citrobacter freundii: a family 4 glycosyl hydrolase in which oxidation is rate-limiting. Biochemistry. 50: 4298-308. PMID 21495656 DOI: 10.1021/bi101808h  0.453
2011 Chan J, Lu A, Bennet AJ. Turnover is rate-limited by deglycosylation for Micromonospora viridifaciens sialidase-catalyzed hydrolyses: conformational implications for the Michaelis complex. Journal of the American Chemical Society. 133: 2989-97. PMID 21322554 DOI: 10.1021/ja109199p  0.552
2011 Telford JC, Yeung JH, Xu G, Kiefel MJ, Watts AG, Hader S, Chan J, Bennet AJ, Moore MM, Taylor GL. The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase (KDNase): structural and mechanistic insights. The Journal of Biological Chemistry. 286: 10783-92. PMID 21247893 DOI: 10.1074/Jbc.M110.207043  0.481
2010 Shidmoossavee FS, Cheng L, Watson JN, Bennet AJ. Brønsted analysis of an enzyme-catalyzed pseudo-deglycosylation reaction: mechanism of desialylation in sialidases. Biochemistry. 49: 6473-84. PMID 20575524 DOI: 10.1021/bi100513u  0.401
2010 Chan J, Lewis AR, Gilbert M, Karwaski MF, Bennet AJ. A direct NMR method for the measurement of competitive kinetic isotope effects. Nature Chemical Biology. 6: 405-7. PMID 20418878 DOI: 10.1038/Nchembio.352  0.523
2006 Narine AA, Watson JN, Bennet AJ. Mechanistic requirements for the efficient enzyme-catalyzed hydrolysis of thiosialosides. Biochemistry. 45: 9319-26. PMID 16866378 DOI: 10.1021/bi0607507  0.369
2006 Lewis BE, Choytun N, Schramm VL, Bennet AJ. Transition states for glucopyranose interconversion Journal of the American Chemical Society. 128: 5049-5058. PMID 16608339 DOI: 10.1021/Ja0573054  0.309
2005 Watson JN, Newstead S, Narine AA, Taylor G, Bennet AJ. Two nucleophilic mutants of the Micromonospora viridifaciens sialidase operate with retention of configuration by two different mechanisms. Chembiochem : a European Journal of Chemical Biology. 6: 1999-2004. PMID 16206228 DOI: 10.1002/Cbic.200500114  0.319
2005 Newstead S, Watson JN, Knoll TL, Bennet AJ, Taylor G. Structure and mechanism of action of an inverting mutant sialidase. Biochemistry. 44: 9117-22. PMID 15966735 DOI: 10.1021/Bi050517T  0.401
2005 Dookhun V, Bennet AJ. Unexpected stability of aryl beta-N-acetylneuraminides in neutral solution: biological implications for sialyl transfer reactions. Journal of the American Chemical Society. 127: 7458-65. PMID 15898795 DOI: 10.1021/ja042280e  0.307
2005 Watson JN, Knoll TL, Chen JH, Chou DT, Borgford TJ, Bennet AJ. Use of conformationally restricted pyridinium alpha-D-N-acetylneuraminides to probe specificity in bacterial and viral sialidases. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 83: 115-22. PMID 15864320 DOI: 10.1139/O04-126  0.307
2004 Watson JN, Newstead S, Dookhun V, Taylor G, Bennet AJ. Contribution of the active site aspartic acid to catalysis in the bacterial neuraminidase from Micromonospora viridifaciens. Febs Letters. 577: 265-9. PMID 15527797 DOI: 10.1016/J.Febslet.2004.10.016  0.326
2003 Watson JN, Dookhun V, Borgford TJ, Bennet AJ. Mutagenesis of the conserved active-site tyrosine changes a retaining sialidase into an inverting sialidase. Biochemistry. 42: 12682-90. PMID 14580216 DOI: 10.1021/Bi035396G  0.35
2000 Leblanc L, Bennet A, Borgford T. Calcium affinity of regulatory sites in skeletal troponin-C is attenuated by N-cap mutations of helix C. Archives of Biochemistry and Biophysics. 384: 296-304. PMID 11368316 DOI: 10.1006/Abbi.2000.2103  0.369
1998 Chou DT, Huang X, Batchelor RJ, Einstein FW, Bennet AJ. Rearrangement of a Homoallylic Alcohol via an Acid-Catalyzed 1,4-Hydride Shift Yields a Saturated Ketone. The Journal of Organic Chemistry. 63: 575-581. PMID 11672047 DOI: 10.1021/jo971465j  0.304
Low-probability matches (unlikely to be authored by this person)
2021 Nejatie A, Steves E, Gauthier N, Baker J, Nesbitt J, McMahon SA, Oehler V, Thornton NJ, Noyovitz B, Khazaei K, Byers BW, Zandberg WF, Gloster TM, Moore MM, Bennet AJ. Kinetic and Structural Characterization of Sialidases (Kdnases) from Ascomycete Fungal Pathogens. Acs Chemical Biology. PMID 34724608 DOI: 10.1021/acschembio.1c00666  0.294
2014 Chakladar S, Wang Y, Clark T, Cheng L, Ko S, Vocadlo DJ, Bennet AJ. A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation. Nature Communications. 5: 5590. PMID 25475952 DOI: 10.1038/Ncomms6590  0.28
2019 Colombo C, Bennet AJ. The physical organic chemistry of glycopyranosyl transfer reactions in solution and enzyme-catalyzed. Current Opinion in Chemical Biology. 53: 145-157. PMID 31689605 DOI: 10.1016/J.Cbpa.2019.08.003  0.272
2018 Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nature Communications. 9: 3243. PMID 30104598 DOI: 10.1038/S41467-018-05702-7  0.271
2024 Bhosale S, Kandalkar S, Gilormini PA, Akintola O, Rowland R, Adabala PJP, King D, Deen MC, Chen X, Davies GJ, Vocadlo DJ, Bennet AJ. Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates. Acs Catalysis. 14: 14769-14779. PMID 39386917 DOI: 10.1021/acscatal.4c04549  0.266
2006 Watson JN, Indurugalla D, Cheng LL, Narine AA, Bennet AJ. The hydrolase and transferase activity of an inverting mutant sialidase using non-natural beta-sialoside substrates. Biochemistry. 45: 13264-75. PMID 17073447 DOI: 10.1021/bi061489x  0.257
2006 Hemeon I, Bennet AJ. Synthesis of 4-deoxy-4-nitrosialic acid. Organic & Biomolecular Chemistry. 4: 2986-92. PMID 16855749 DOI: 10.1039/b605218e  0.25
2024 Akintola O, Bhosale S, Bennet AJ. Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases. Molecules (Basel, Switzerland). 29. PMID 39459237 DOI: 10.3390/molecules29204870  0.247
2010 Warwas ML, Yeung JH, Indurugalla D, Mooers AO, Bennet AJ, Moore MM. Cloning and characterization of a sialidase from the filamentous fungus, Aspergillus fumigatus. Glycoconjugate Journal. 27: 533-48. PMID 20652740 DOI: 10.1007/s10719-010-9299-9  0.246
2016 Adamson C, Pengelly RJ, Shamsi Kazem Abadi S, Chakladar S, Draper J, Britton R, Gloster TM, Bennet AJ. Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars. Angewandte Chemie (International Ed. in English). PMID 27783466 DOI: 10.1002/Anie.201607431  0.243
2017 Shamsi Kazem Abadi S, Tran M, Yadav A, Adabala PJP, Chakladar S, Bennet AJ. A New Class of Glycoside Hydrolase Mechanism-Based Covalent Inhibitors: Glycosylation Transition State Conformations. Journal of the American Chemical Society. PMID 28723089 DOI: 10.1021/jacs.7b05065  0.242
2023 Bhosale S, Deen MC, Proceviat C, Hettle A, Winter DK, Brockerman J, Levene M, Bennet AJ, Spino C, Boraston AB, Vocadlo DJ. A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from . Acs Chemical Biology. 18: 1730-1737. PMID 37531094 DOI: 10.1021/acschembio.3c00053  0.238
2017 Farren-Dai M, Thompson JR, Bernardi A, Colombo C, Bennet AJ. Observation of a tricyclic[4.1.0.02,4]heptane during a Michael addition-ring closure reaction and a computational study on its mechanism of formation. The Journal of Organic Chemistry. PMID 29083180 DOI: 10.1021/Acs.Joc.7B02218  0.233
2016 Colombo C, Pinto BM, Bernardi A, Bennet AJ. Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold. Organic & Biomolecular Chemistry. 14: 6539-53. PMID 27305457 DOI: 10.1039/C6Ob00999A  0.218
2018 Colombo C, Podlipnik Č, Lo Presti L, Niikura M, Bennet AJ, Bernardi A. Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase. Plos One. 13: e0193623. PMID 29489903 DOI: 10.1371/Journal.Pone.0193623  0.211
2006 Indurugalla D, Watson JN, Bennet AJ. Natural sialoside analogues for the determination of enzymatic rate constants. Organic & Biomolecular Chemistry. 4: 4453-9. PMID 17268638 DOI: 10.1039/b613909d  0.21
2017 Sannikova N, Lewis AR, Bennet AJ. Measurement of Kinetic Isotope Effects by Continuously Monitoring Isotopologue Ratios Using NMR Spectroscopy. Methods in Enzymology. 596: 547-571. PMID 28911784 DOI: 10.1016/bs.mie.2017.06.034  0.21
2005 Newstead SL, Watson JN, Bennet AJ, Taylor G. Galactose recognition by the carbohydrate-binding module of a bacterial sialidase. Acta Crystallographica. Section D, Biological Crystallography. 61: 1483-91. PMID 16239725 DOI: 10.1107/S0907444905026132  0.202
2007 Wang Y, Bennet AJ. A potent bicyclic inhibitor of a family 27 alpha-galactosidase. Organic & Biomolecular Chemistry. 5: 1731-8. PMID 17520141 DOI: 10.1039/b704509c  0.194
2004 Joe K, Borgford TJ, Bennet AJ. Generation of a thermostable and denaturant-resistant peptide ligase. Biochemistry. 43: 7672-7. PMID 15196009 DOI: 10.1021/Bi0496337  0.19
2007 Warwas ML, Watson JN, Bennet AJ, Moore MM. Structure and role of sialic acids on the surface of Aspergillus fumigatus conidiospores. Glycobiology. 17: 401-10. PMID 17223648 DOI: 10.1093/glycob/cwl085  0.186
2017 Carroll CS, Grieve CL, Murugathasan I, Bennet AJ, Czekster CM, Lui H, Naismith J, Moore MM. The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family. The International Journal of Biochemistry & Cell Biology. PMID 28610916 DOI: 10.1016/J.Biocel.2017.06.005  0.186
2011 Poon LC, Methot SP, Morabi-Pazooki W, Pio F, Bennet AJ, Sen D. Guanine-rich RNAs and DNAs that bind heme robustly catalyze oxygen transfer reactions. Journal of the American Chemical Society. 133: 1877-84. PMID 21265562 DOI: 10.1021/Ja108571A  0.18
2006 Feldman AR, Leung EK, Bennet AJ, Sen D. The RNA-cleaving bipartite DNAzyme is a distinctive metalloenzyme. Chembiochem : a European Journal of Chemical Biology. 7: 98-105. PMID 16345112 DOI: 10.1002/Cbic.200500264  0.176
2021 Shumayrikh NM, Warren JJ, Bennet AJ, Sen D. A heme•DNAzyme activated by hydrogen peroxide catalytically oxidizes thioethers by direct oxygen atom transfer rather than by a Compound I-like intermediate. Nucleic Acids Research. PMID 33476369 DOI: 10.1093/nar/gkab007  0.165
2019 Ganga-Sah Y, Leznoff DB, Bennet AJ. Synthesis of Sterically Congested 2,2'-Bi(Adamantyl)-based Alcohol and Amines. The Journal of Organic Chemistry. PMID 31682451 DOI: 10.1021/Acs.Joc.9B02293  0.151
2017 Nesbitt JR, Steves EY, Schonhofer CR, Cait A, Manku SS, Yeung JHF, Bennet AJ, McNagny KM, Choy JC, Hughes MR, Moore MM. The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice. Frontiers in Microbiology. 8: 2706. PMID 29403452 DOI: 10.3389/fmicb.2017.02706  0.1
2016 Barlev A, Sekhon GS, Bennet AJ, Sen D. DNA repair by DNA: The UV1C DNAzyme catalyzes photoreactivation of cyclobutane thymine dimers in DNA more effectively than their de novo formation. Biochemistry. PMID 27726378 DOI: 10.1021/Acs.Biochem.6B00951  0.1
2007 Das AK, Moatazedi Z, Mund G, Bennet AJ, Batchelor RJ, Leznoff DB. Chelating or bridging? Halide-controlled binding mode of diamido donor ligands in iron(III) complexes. Inorganic Chemistry. 46: 366-8. PMID 17279810 DOI: 10.1021/Ic061832M  0.096
2024 Radford CL, Saatkamp T, Bennet AJ, Holdcroft S. An organic proton cage that is ultra-resistant to hydroxide-promoted degradation. Nature Communications. 15: 3395. PMID 38649343 DOI: 10.1038/s41467-024-47809-0  0.095
2018 Ren W, Pengelly R, Farren-Dai M, Abadi SSK, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nature Communications. 9: 3700. PMID 30194298 DOI: 10.1038/S41467-018-06264-4  0.073
2024 Nejatie A, Proceviat C, Gros C, Steves E, Moore MM, Vocadlo DJ, Bennet AJ. A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases. Glycobiology. PMID 39569748 DOI: 10.1093/glycob/cwae094  0.071
2013 Shidmoossavee FS, Watson JN, Bennet AJ. Chemical insight into the emergence of influenza virus strains that are resistant to Relenza. Journal of the American Chemical Society. 135: 13254-7. PMID 24001125 DOI: 10.1021/ja405916q  0.036
2006 Bennet A. Trading on ambiguity. Nursing New Zealand (Wellington, N.Z. : 1995). 12: 5; author reply 5. PMID 16767864  0.01
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