Bernhard K. Keppler - Publications

Affiliations: 
University of Vienna, Wien, Wien, Austria 

460 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Getreuer P, Marretta L, Toyoglu E, Dömötör O, Hejl M, Prado-Roller A, Cseh K, Legin AA, Jakupec MA, Barone G, Terenzi A, Keppler BK, Kandioller W. Investigating the anticancer potential of 4-phenylthiazole derived Ru(II) and Os(II) metalacycles. Dalton Transactions (Cambridge, England : 2003). 53: 5567-5579. PMID 38426897 DOI: 10.1039/d4dt00245h  0.334
2023 Maier T, Wutschitz J, Gajic N, Hejl M, Cseh K, Mai S, Jakupec MA, Galanski MS, Keppler BK. Not the usual suspect - an unexpected organometallic product during the synthesis of cytotoxic platinum(II) complexes. Dalton Transactions (Cambridge, England : 2003). PMID 37855721 DOI: 10.1039/d3dt01736b  0.38
2023 Kastner A, Schueffl H, Yassemipour PA, Keppler BK, Heffeter P, Kowol CR. Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie (International Ed. in English). 62: e202311468. PMID 37703130 DOI: 10.1002/anie.202311468  0.339
2023 Cseh K, Berasaluce I, Fuchs V, Banc A, Schweikert A, Prado-Roller A, Hejl M, Wernitznig D, Koellensperger G, Jakupec MA, Kandioller W, Malarek MS, Keppler BK. Anticancer Tungstenocenes with a Diverse Set of (-), (,-) and (,-) Chelates-A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models. Pharmaceutics. 15. PMID 37514061 DOI: 10.3390/pharmaceutics15071875  0.32
2023 Kastner A, Mendrina T, Bachmann F, Berger W, Keppler BK, Heffeter P, Kowol CR. Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs. Inorganic Chemistry Frontiers. 10: 4126-4138. PMID 37440920 DOI: 10.1039/d3qi00968h  0.314
2023 Lerchbammer-Kreith Y, Hejl M, Vician P, Jakupec MA, Berger W, Galanski MS, Keppler BK. Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes-A More Selective Anticancer Treatment? Pharmaceutics. 15. PMID 37242758 DOI: 10.3390/pharmaceutics15051515  0.318
2023 Mészáros JP, Kandioller W, Spengler G, Prado-Roller A, Keppler BK, Enyedy ÉA. Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation. Pharmaceutics. 15. PMID 36839678 DOI: 10.3390/pharmaceutics15020356  0.317
2022 Liu X, Wenisch D, Barth MC, Cseh K, Kowol CR, Jakupec MA, Gibson D, Keppler BK, Weigand W. Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions (Cambridge, England : 2003). PMID 36189643 DOI: 10.1039/d2dt02217f  0.345
2022 Liu X, Barth MC, Cseh K, Kowol CR, Jakupec MA, Keppler BK, Gibson D, Weigand W. Oxoplatin-based Pt(IV) lipoate complexes and their biological activity. Chemistry & Biodiversity. PMID 36026613 DOI: 10.1002/cbdv.202200695  0.325
2022 Pósa V, Hajdu B, Tóth G, Dömötör O, Kowol CR, Keppler BK, Spengler G, Gyurcsik B, Enyedy ÉA. The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry. 231: 111786. PMID 35287037 DOI: 10.1016/j.jinorgbio.2022.111786  0.317
2022 Foteeva LS, Nosova YN, Nazarov AA, Keppler BK, Timerbaev AR. Versatile analytical methodology for evaluation of drug-like properties of potentially multi-targeting anticancer metallodrugs. Analytical Sciences : the International Journal of the Japan Society For Analytical Chemistry. PMID 35286638 DOI: 10.1007/s44211-022-00076-9  0.352
2022 Geisler H, Harringer S, Wenisch D, Urban R, Jakupec MA, Kandioller W, Keppler BK. Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines. Chemistryopen. e202200019. PMID 35212190 DOI: 10.1002/open.202200019  0.307
2021 Riedl CA, Rosner A, Harringer S, Salomon P, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics. Journal of Inorganic Biochemistry. 225: 111618. PMID 34607124 DOI: 10.1016/j.jinorgbio.2021.111618  0.33
2021 Petrasheuskaya TV, Wernitznig D, Kiss MA, May NV, Wenisch D, Keppler BK, Frank É, Enyedy ÉA. Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 34453218 DOI: 10.1007/s00775-021-01891-7  0.322
2021 Enyedy ÉA, Petrasheuskaya TV, Kiss MA, Wernitznig D, Wenisch D, Keppler BK, Spengler G, May NV, Frank É, Dömötör O. Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity. Journal of Inorganic Biochemistry. 220: 111468. PMID 33951554 DOI: 10.1016/j.jinorgbio.2021.111468  0.303
2020 Mathuber M, Schueffl H, Dömötör O, Karnthaler C, Enyedy ÉA, Heffeter P, Keppler BK, Kowol CR. Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs. Inorganic Chemistry. 59: 17794-17810. PMID 33222438 DOI: 10.1021/acs.inorgchem.0c03083  0.32
2020 Harringer S, Wernitznig D, Gajic N, Diridl A, Wenisch D, Hejl M, Jakupec MA, Theiner S, Koellensperger G, Kandioller W, Keppler BK. Introducing -, -, and -donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes. Dalton Transactions (Cambridge, England : 2003). 49: 15693-15711. PMID 33135027 DOI: 10.1039/d0dt03165h  0.316
2020 Hager S, Pape VFS, Pósa V, Montsch B, Uhlik L, Szakács G, Tóth S, Jabronka N, Keppler BK, Kowol CR, Enyedy EA, Heffeter P. High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction and impact on drug-resistant cells of anticancer thiosemicarbazones. Antioxidants & Redox Signaling. PMID 32336116 DOI: 10.1089/Ars.2019.7854  0.366
2020 Mokesch S, Cseh K, Geisler H, Hejl M, Klose MHM, Roller A, Meier-Menches SM, Jakupec MA, Kandioller W, Keppler BK. Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles. Frontiers in Chemistry. 8: 209. PMID 32318543 DOI: 10.3389/Fchem.2020.00209  0.453
2020 Foteeva LS, Kuznetsova OV, Keppler BK. How versatile is the use of ultrafiltration to study biointeractions of therapeutic metallodrugs? Analytical Biochemistry. 598: 113697. PMID 32224145 DOI: 10.1016/J.Ab.2020.113697  0.316
2020 Legina MS, Nogueira JJ, Kandioller W, Jakupec MA, González L, Keppler BK. Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 32193613 DOI: 10.1007/S00775-020-01775-2  0.386
2020 Bielec B, Poetsch I, Ahmed E, Heffeter P, Keppler BK, Kowol CR. Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib. Molecules (Basel, Switzerland). 25. PMID 32143435 DOI: 10.3390/Molecules25051149  0.327
2020 Ma T, Yang P, Dammann I, Lin Z, Mougharbel AS, Li MX, Adǎscǎliţei F, Mitea R, Silvestru C, Thorstenson C, Ullrich MS, Cseh K, Jakupec MA, Keppler BK, Donalisio M, et al. Tetra-(-tolyl)antimony(III)-Containing Heteropolytungstates, [{(-tolyl)Sb}(-α-XWO)] (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. Inorganic Chemistry. PMID 32037809 DOI: 10.1021/Acs.Inorgchem.9B03322  0.354
2020 Harringer S, Happl B, Ozenil M, Kast C, Hejl M, Wernitznig D, Legin AA, Schweikert A, Gajic N, Roller A, Koellensperger G, Jakupec MA, Kandioller W, Keppler BK. Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior. Chemistry (Weinheim An Der Bergstrasse, Germany). 26: 5419-5433. PMID 31958176 DOI: 10.1002/Chem.201905546  0.399
2020 Geisler H, Wernitznig D, Hejl M, Gajic N, Jakupec MA, Kandioller W, Keppler BK. Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour. Dalton Transactions (Cambridge, England : 2003). 49: 1393-1397. PMID 31950944 DOI: 10.1039/C9Dt04462K  0.338
2020 Hager S, Pape VF, Pósa V, Montsch B, Uhlik L, Szakàcs G, Tóth S, Jabronka N, Keppler BK, Berger W, Kowol CR, Enyedy ÉA, Heffeter P. Abstract 1939: Improved activity and paraptosis-induction of anticancer thiosemicarbazones requires high copper(II) complex stability and slow reduction kinetics Cancer Research. 80: 1939-1939. DOI: 10.1158/1538-7445.Am2020-1939  0.441
2020 Afanasenko AM, Chulkova TG, Boyarskaya IA, Islamova RM, Legin AA, Keppler BK, Selivanov SI, Vereshchagin AN, Elinson MN, Haukka M. C,N-chelated diaminocarbene platinum(II) complexes derived from 3,4-diaryl-1H-pyrrol-2,5-diimines and cis-dichlorobis(isonitrile)platinum(II): Synthesis, cytotoxicity, and catalytic activity in hydrosilylation reactions Journal of Organometallic Chemistry. 923: 121435. DOI: 10.1016/J.Jorganchem.2020.121435  0.425
2020 Mészáros JP, Geisler H, Poljarević JM, Roller A, Legina MS, Hejl M, Jakupec MA, Keppler BK, Kandioller W, Enyedy ÉA. Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations Journal of Organometallic Chemistry. 907: 121070. DOI: 10.1016/J.Jorganchem.2019.121070  0.431
2020 Harringer S, Matzinger M, Gajic N, Hejl M, Jakupec MA, Kandioller W, Keppler BK. First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations Inorganica Chimica Acta. 513: 119919. DOI: 10.1016/J.Ica.2020.119919  0.464
2019 Rusz M, Rampler E, Keppler BK, Jakupec MA, Koellensperger G. Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids. Metabolites. 9. PMID 31847430 DOI: 10.3390/Metabo9120304  0.335
2019 Berasaluce I, Cseh K, Roller A, Hejl M, Heffeter P, Berger W, Jakupec MA, Kandioller W, Malarek MS, Keppler BK. The first anticancer tris(pyrazolyl)borate molybdenum(IV) complexes: tested in vitro and in vivo - a comparison of O,O-, S,O-, and N,N-chelate effects. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31560142 DOI: 10.1002/Chem.201903605  0.382
2019 Galvez L, Rusz M, Schwaiger-Haber M, El Abiead Y, Hermann G, Jungwirth U, Berger W, Keppler BK, Jakupec MA, Koellensperger G. Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics. Metallomics : Integrated Biometal Science. PMID 31497817 DOI: 10.1039/C9Mt00141G  0.32
2019 Hager LA, Mokesch S, Kieler C, Alonso-de Castro S, Baier D, Roller A, Kandioller W, Keppler BK, Berger W, Salassa L, Terenzi A. Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition. Dalton Transactions (Cambridge, England : 2003). PMID 31292575 DOI: 10.1039/C9Dt02078K  0.421
2019 Mokesch S, Schwarz D, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK. Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group. Molecules (Basel, Switzerland). 24. PMID 31252521 DOI: 10.3390/Molecules24132373  0.417
2019 Domarco O, Kieler C, Pirker C, Dinhof C, Englinger B, Reisecker JM, Timelthaler G, García MD, Peinador C, Keppler BK, Berger W, Terenzi A. Subcellular duplex DNA and G-quadruplex interaction profiling of a hexagonal Pt(II) metallacycle. Angewandte Chemie (International Ed. in English). PMID 31002438 DOI: 10.1002/Anie.201900934  0.322
2019 Wernitznig D, Kiakos K, Del Favero G, Harrer N, Machat H, Osswald A, Jakupec MA, Wernitznig A, Sommergruber W, Keppler BK. First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro. Metallomics : Integrated Biometal Science. 11: 1044-1048. PMID 30942231 DOI: 10.1039/C9Mt00051H  0.364
2019 Kastner A, Poetsch I, Mayr J, Burda JV, Roller A, Heffeter P, Keppler BK, Kowol CR. A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt Complexes under Physiological Conditions. Angewandte Chemie (International Ed. in English). 58: 7464-7469. PMID 30870571 DOI: 10.1002/Anie.201900682  0.403
2019 Heffeter P, Pape VFS, Enyedy ÉA, Keppler BK, Szakacs G, Kowol CR. Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development. Antioxidants & Redox Signaling. 30: 1062-1082. PMID 29334758 DOI: 10.1089/Ars.2017.7487  0.305
2019 Hizal S, Hejl M, Jakupec MA, Galanski M, Keppler BK. Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes Inorganica Chimica Acta. 491: 76-83. DOI: 10.1016/J.Ica.2019.03.036  0.442
2019 Höfer D, Cseh K, Hejl M, Roller A, Jakupec MA, Galanski M, Keppler BK. Synthesis, characterization, cytotoxic activity, and 19F NMR spectroscopic investigations of (OC-6-33)-diacetato(ethane-1,2-diamine)bis(3,3,3-trifluoropropanoato)platinum(IV) and its platinum(II) counterpart Inorganica Chimica Acta. 490: 190-199. DOI: 10.1016/J.Ica.2019.02.017  0.472
2018 Alonso-de Castro S, Terenzi A, Hager S, Englinger B, Faraone A, Martínez JC, Galanski M, Keppler BK, Berger W, Salassa L. Biological activity of Pt prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis. Scientific Reports. 8: 17198. PMID 30464209 DOI: 10.1038/S41598-018-35655-2  0.317
2018 Carboni S, Zucca A, Stoccoro S, Maiore L, Arca M, Ortu F, Artner C, Keppler BK, Meier-Menches SM, Casini A, Cinellu MA. New Variations on the Theme of Gold(III) CNN Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization. Inorganic Chemistry. PMID 30457328 DOI: 10.1021/Acs.Inorgchem.8B02604  0.468
2018 Kallus S, Uhlik L, van Schoonhoven S, Pelivan K, Berger W, Enyedy ÉA, Hofmann T, Heffeter P, Kowol CR, Keppler BK. Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes. Journal of Inorganic Biochemistry. 190: 85-97. PMID 30384010 DOI: 10.1016/J.Jinorgbio.2018.10.006  0.461
2018 Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakács G, Keppler BK, Berger W, et al. The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition. Cell Death & Disease. 9: 1052. PMID 30323190 DOI: 10.1038/S41419-018-1102-Z  0.344
2018 Klose MHM, Schöberl A, Heffeter P, Berger W, Hartinger CG, Koellensperger G, Meier-Menches SM, Keppler BK. Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS. Monatshefte Fur Chemie. 149: 1719-1726. PMID 30237619 DOI: 10.1007/S00706-018-2280-1  0.367
2018 Galvez L, Theiner S, Grabarics M, Kowol CR, Keppler BK, Hann S, Koellensperger G. Critical assessment of different methods for quantitative measurement of metallodrug-protein associations. Analytical and Bioanalytical Chemistry. PMID 30155703 DOI: 10.1007/S00216-018-1328-8  0.315
2018 Kallus S, Englinger B, Senkiv J, Laemmerer A, Heffeter P, Berger W, Kowol CR, Keppler BK. Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30121385 DOI: 10.1016/J.Nano.2018.08.001  0.302
2018 Nazarov AA, Mendoza-Ferri MG, Hanif M, Keppler BK, Dyson PJ, Hartinger CG. Understanding the interactions of diruthenium anticancer agents with amino acids. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 30046902 DOI: 10.1007/S00775-018-1597-X  0.405
2018 Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I. Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction. European Journal of Medicinal Chemistry. 156: 148-161. PMID 30006161 DOI: 10.1016/J.Ejmech.2018.06.056  0.393
2018 Frensemeier LM, Mayr J, Koellensperger G, Keppler BK, Kowol CR, Karst U. Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS) Analyst. 143: 1997-2001. PMID 29629473 DOI: 10.1039/C8An00258D  0.342
2018 Theiner S, Grabarics M, Galvez L, Varbanov HP, Sommerfeld NS, Galanski M, Keppler BK, Koellensperger G. The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs - an HPLC-ICP-MS study. Dalton Transactions (Cambridge, England : 2003). PMID 29560976 DOI: 10.1039/C7Dt04537A  0.419
2018 Riedl CA, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK. N- and S-donor leaving groups in triazole-based ruthena(ii)cycles: potent anticancer activity, selective activation, and mode of action studies. Dalton Transactions (Cambridge, England : 2003). 47: 4625-4638. PMID 29520401 DOI: 10.1039/C8Dt00449H  0.426
2018 Pelivan K, Frensemeier LM, Karst U, Koellensperger G, Heffeter P, Keppler BK, Kowol CR. Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones. Analytical and Bioanalytical Chemistry. 410: 2343-2361. PMID 29476231 DOI: 10.1007/S00216-018-0889-X  0.308
2018 Babak MV, Pfaffeneder-Kmen M, Meier-Menches SM, Legina MS, Theiner S, Licona C, Orvain C, Hejl M, Hanif M, Jakupec MA, Keppler BK, Gaiddon C, Hartinger CG. Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry. 57: 2851-2864. PMID 29442506 DOI: 10.1021/Acs.Inorgchem.7B03210  0.432
2018 Meier-Menches SM, Gerner C, Berger W, Hartinger CG, Keppler BK. Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development. Chemical Society Reviews. 47: 909-928. PMID 29170783 DOI: 10.1039/C7Cs00332C  0.332
2018 Pashkunova-Martic I, Losantos BC, Kandler N, Keppler B. Studies of KP46 and KP1019 and the hydrolysis product of KP1019 in lipiodol emulsions: preparation and initial characterizations as potential theragnostic agents. Current Drug Delivery. 15: 134-142. PMID 28000552 DOI: 10.2174/1567201813666161220153702  0.398
2018 Wernitznig D, Favero GD, Kiakos K, Harrer N, Machat H, Marko D, Jakupec M, Sommergruber W, Keppler BK. Abstract 4395: KP-1339 (IT-139) induces the hallmarks of immunogenic cell death in a colon cancer 3D model in vitro Cancer Research. 78: 4395-4395. DOI: 10.1158/1538-7445.Am2018-4395  0.323
2018 Mészáros JP, Dömötör O, Hackl CM, Roller A, Keppler BK, Kandioller W, Enyedy EAA. Structural and solution equilibrium studies on half-sandwich organorhodium complexes of (N,N) donor bidentate ligands New Journal of Chemistry. 42: 11174-11184. DOI: 10.1039/C8Nj01681J  0.408
2018 Kandioller W, Reikersdorfer M, Theiner S, Roller A, Hejl M, Jakupec MA, Malarek MS, Keppler BK. The Impact of Leaving Group Variation on the Anticancer Activity of Molybdenocenes Organometallics. 37: 3909-3916. DOI: 10.1021/Acs.Organomet.8B00582  0.341
2018 Streciwilk W, Terenzi A, Lo Nardo F, Prochnow P, Bandow JE, Keppler BK, Ott I. Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands European Journal of Inorganic Chemistry. 2018: 3104-3112. DOI: 10.1002/Ejic.201800384  0.387
2017 Hanif M, Meier SM, Adhireksan Z, Henke H, Martic S, Movassaghi S, Labib M, Kandioller W, Jamieson SMF, Hejl M, Jakupec MA, Kraatz HB, Davey CA, Keppler BK, Hartinger CG. Functionalization of Ruthenium(II)(η -p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies. Chempluschem. 82: 841-847. PMID 31961568 DOI: 10.1002/Cplu.201700050  0.438
2017 Bonsignore R, Russo F, Terenzi A, Spinello A, Lauria A, Gennaro G, Almerico AM, Keppler BK, Barone G. The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA. Journal of Inorganic Biochemistry. 178: 106-114. PMID 29128495 DOI: 10.1016/J.Jinorgbio.2017.10.010  0.385
2017 Theiner S, Van Malderen SJM, Van Acker T, Legin A, Keppler BK, Vanhaecke F, Koellensperger G. Fast High-Resolution Laser Ablation-Inductively Coupled Plasma Mass Spectrometry Imaging of the Distribution of Platinum-Based Anticancer Compounds in Multicellular Tumor Spheroids. Analytical Chemistry. 89: 12641-12645. PMID 29105484 DOI: 10.1021/Acs.Analchem.7B02681  0.32
2017 Hackl CM, Schoenhacker-Alte B, Klose MHM, Henke H, Legina MS, Jakupec MA, Berger W, Keppler BK, Brüggemann O, Teasdale I, Heffeter P, Kandioller W. Synthesis and in vivo anticancer evaluation of poly(organo)phosphazene-based metallodrug conjugates. Dalton Transactions (Cambridge, England : 2003). PMID 28862707 DOI: 10.1039/C7Dt01767G  0.413
2017 Nosova YN, Zenin IV, Maximova VP, Zhidkova EM, Kirsanov KI, Lesovaya EA, Lobas AA, Gorshkov MV, Kovaleva ON, Milaeva ER, Galanski M, Keppler BK, Nazarov AA. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorganic Chemistry and Applications. 2017: 4736321. PMID 28804273 DOI: 10.1155/2017/4736321  0.422
2017 Pelivan K, Frensemeier L, Karst U, Koellensperger G, Bielec B, Hager S, Heffeter P, Keppler BK, Kowol CR. Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS. The Analyst. 142: 3165-3176. PMID 28745337 DOI: 10.1039/C7An00902J  0.312
2017 Platzer S, Leyma R, Wolske S, Kandioller W, Heid E, Schröder C, Schagerl M, Krachler R, Jirsa F, Keppler BK. Thioglycolate-based task-specific ionic liquids: Metal extraction abilities vs acute algal toxicity. Journal of Hazardous Materials. 340: 113-119. PMID 28711828 DOI: 10.1016/J.Jhazmat.2017.06.053  0.306
2017 Höfer D, Varbanov HP, Hejl M, Jakupec MA, Roller A, Galanski M, Keppler BK. Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes. Journal of Inorganic Biochemistry. 174: 119-129. PMID 28666155 DOI: 10.1016/J.Jinorgbio.2017.06.005  0.468
2017 Varbanov HP, Ortiz D, Höfer D, Menin L, Galanski M, Keppler BK, Dyson PJ. Oxaliplatin reacts with DMSO only in the presence of water. Dalton Transactions (Cambridge, England : 2003). PMID 28654098 DOI: 10.1039/C7Dt01628J  0.306
2017 Klose MHM, Hejl M, Heffeter P, Jakupec MA, Meier-Menches SM, Berger W, Keppler BK. Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue. The Analyst. PMID 28585637 DOI: 10.1039/C7An00350A  0.309
2017 Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, Bileck A, Alte B, Mader JC, Jana S, Chatterjee A, Bhattacharyya A, Hejl M, Jakupec MA, Heffeter P, ... ... Keppler BK, et al. An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin. Angewandte Chemie (International Ed. in English). PMID 28547791 DOI: 10.1002/Anie.201702242  0.3
2017 Mayr J, Heffeter P, Groza D, Galvez L, Koellensperger G, Roller A, Alte B, Haider M, Berger W, Kowol CR, Keppler BK. An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo. Chemical Science. 8: 2241-2250. PMID 28507680 DOI: 10.1039/C6Sc03862J  0.412
2017 Mayr J, Hager S, Koblmüller B, Klose MH, Holste K, Fischer B, Pelivan K, Berger W, Heffeter P, Kowol CR, Keppler BK. EGFR-targeting peptide-coupled platinum(IV) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 28405842 DOI: 10.1007/S00775-017-1450-7  0.322
2017 Tamasi G, Merlino A, Scaletti F, Heffeter P, Legin AA, Jakupec MA, Berger W, Messori L, Keppler BK, Cini R. {Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo. Dalton Transactions (Cambridge, England : 2003). PMID 28207024 DOI: 10.1039/C6Dt04295C  0.43
2017 Göschl S, Schreiber-Brynzak E, Pichler V, Cseh K, Heffeter P, Jungwirth U, Jakupec MA, Berger W, Keppler BK. Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models. Metallomics : Integrated Biometal Science. PMID 28205649 DOI: 10.1039/C6Mt00226A  0.432
2017 Blazevic A, Hummer AA, Heffeter P, Berger W, Filipits M, Cibin G, Keppler BK, Rompel A. Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse. Scientific Reports. 7: 40966. PMID 28112202 DOI: 10.1038/Srep40966  0.411
2017 Riedl CA, Flocke LS, Hejl M, Roller A, Klose MH, Jakupec MA, Kandioller W, Keppler BK. Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates. Inorganic Chemistry. 56: 528-541. PMID 27996251 DOI: 10.1021/Acs.Inorgchem.6B02430  0.432
2017 Orlowska E, Roller A, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. Synthetic iron complexes as models for natural iron-humic compounds: Synthesis, characterization and algal growth experiments. The Science of the Total Environment. 577: 94-104. PMID 27810305 DOI: 10.1016/J.Scitotenv.2016.10.109  0.36
2017 Orlowska E, Enyedy ÉA, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. β-O-4 type dilignol compounds and their iron complexes for modeling of iron binding to humic acids: synthesis, characterization, electrochemical studies and algal growth experiments New Journal of Chemistry. 41: 11546-11555. DOI: 10.1039/C7Nj02328F  0.386
2017 Bolotin DS, Demakova MY, Legin AA, Suslonov VV, Nazarov AA, Jakupec MA, Keppler BK, Kukushkin VY. Amidoxime platinum( ii ) complexes: pH-dependent highly selective generation and cytotoxic activity New Journal of Chemistry. 41: 6840-6848. DOI: 10.1039/C7Nj00982H  0.444
2017 Dömötör O, Hackl CM, Bali K, Roller A, Hejl M, Jakupec MA, Keppler BK, Kandioller W, Enyedy ÉA. Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O,N) donor bidentate ligands Journal of Organometallic Chemistry. 846: 287-295. DOI: 10.1016/J.Jorganchem.2017.06.027  0.421
2017 Jakusch T, Kozma K, Enyedy ÉA, May NV, Roller A, Kowol CR, Keppler BK, Kiss T. Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure Inorganica Chimica Acta. 472: 243-253. DOI: 10.1016/J.Ica.2017.08.018  0.359
2017 Dömötör O, May NV, Pelivan K, Kiss T, Keppler BK, Kowol CR, Enyedy ÉA. A comparative study of α-N-pyridyl thiosemicarbazones: Spectroscopic properties, solution stability and copper(II) complexation Inorganica Chimica Acta. 472: 264-275. DOI: 10.1016/J.Ica.2017.07.001  0.376
2017 Sommerfeld NS, Strohhofer D, Cseh K, Theiner S, Jakupec MA, Koellensperger G, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands – Synthesis, Characterization, and Cytotoxicity European Journal of Inorganic Chemistry. 2017: 4049-4054. DOI: 10.1002/Ejic.201700753  0.437
2017 Sommerfeld NS, Gülzow J, Roller A, Cseh K, Jakupec MA, Grohmann A, Galanski M, Keppler BK. Antiproliferative Copper(II) and Platinum(II) Complexes with Bidentate N,N‐Donor Ligands European Journal of Inorganic Chemistry. 2017: 3115-3124. DOI: 10.1002/Ejic.201700416  0.388
2017 Höfer D, Galanski M, Keppler BK. Synthesis, Characterization, and Time‐Dependent NMR Spectroscopy Studies of (SP‐4‐2)‐[(trans‐1R,2R/1S,2S‐15N2)‐Cyclohexane‐1,2‐diamine][(13C2)oxalato]platinum(II) European Journal of Inorganic Chemistry. 2017: 2347-2354. DOI: 10.1002/Ejic.201601503  0.315
2017 Nosova YN, Foteeva LS, Zenin IV, Fetisov TI, Kirsanov KI, Yakubovskaya MG, Antonenko TA, Tafeenko VA, Aslanov LA, Lobas AA, Gorshkov MV, Galanski M, Keppler BK, Timerbaev AR, Milaeva ER, et al. Enhancing the cytotoxic activity of anticancer Pt(IV) complexes by introduction of lonidamine as an axial ligand European Journal of Inorganic Chemistry. 2017: 1785-1791. DOI: 10.1002/Ejic.201600857  0.431
2017 Hanif M, Meier SM, Adhireksan Z, Henke H, Martic S, Movassaghi S, Labib M, Kandioller W, Jamieson SMF, Hejl M, Jakupec MA, Kraatz H, Davey CA, Keppler BK, Hartinger CG. Back Cover: Functionalization of Ruthenium(II)(η6 -p -cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies (ChemPlusChem 6/2017) Chempluschem. 82. DOI: 10.1002/Cplu.201700176  0.374
2016 Legin AA, Theiner S, Schintlmeister A, Reipert S, Heffeter P, Jakupec MA, Mayr J, Varbanov HP, Kowol CR, Galanski M, Berger W, Wagner M, Keppler BK. Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney. Chemical Science. 7: 3052-3061. PMID 29997796 DOI: 10.1039/C5Sc04383B  0.305
2016 Streciwilk W, Terenzi A, Misgeld R, Frias C, Jones PG, Prokop A, Keppler B, Ott I. Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents. Chemmedchem. PMID 27997743 DOI: 10.1002/Cmdc.201600557  0.392
2016 Platzer S, Kar M, Leyma R, Chib S, Roller A, Jirsa F, Krachler R, MacFarlane DR, Kandioller W, Keppler BK. Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties. Journal of Hazardous Materials. PMID 27856054 DOI: 10.1016/J.Jhazmat.2016.10.054  0.311
2016 Hackl CM, Legina MS, Pichler V, Schmidlehner M, Roller A, Dömötör O, Enyedy EA, Jakupec MA, Kandioller W, Keppler BK. Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 17269-17281. PMID 27759173 DOI: 10.1002/Chem.201603206  0.421
2016 Karnthaler-Benbakka C, Groza D, Koblmüller B, Terenzi A, Holste K, Haider M, Baier D, Berger W, Heffeter P, Kowol CR, Keppler BK. Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs. Chemmedchem. PMID 27706901 DOI: 10.1002/Cmdc.201600417  0.305
2016 Terenzi A, Pirker C, Keppler BK, Berger W. Anticancer metal drugs and immunogenic cell death. Journal of Inorganic Biochemistry. PMID 27350082 DOI: 10.1016/J.Jinorgbio.2016.06.021  0.344
2016 Kowol CR, Miklos W, Pfaff S, Hager S, Kallus S, Pelivan K, Kubanik M, Enyedy EA, Berger W, Heffeter P, Keppler BK. Impact of stepwise NH2-methylation of Triapine on the physico-chemical properties, anticancer activity and resistance circumvention. Journal of Medicinal Chemistry. PMID 27336684 DOI: 10.1021/Acs.Jmedchem.6B00342  0.352
2016 Bonsignore R, Terenzi A, Spinello A, Martorana A, Lauria A, Almerico AM, Keppler BK, Barone G. G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes. Journal of Inorganic Biochemistry. PMID 27230387 DOI: 10.1016/J.Jinorgbio.2016.05.010  0.367
2016 Kubanik M, Kandioller W, Kim K, Anderson RF, Klapproth E, Jakupec MA, Roller A, Söhnel T, Keppler BK, Hartinger CG. Towards targeting anticancer drugs: ruthenium(ii)-arene complexes with biologically active naphthoquinone-derived ligand systems. Dalton Transactions (Cambridge, England : 2003). PMID 27214822 DOI: 10.1039/C6Dt01110A  0.476
2016 Bijelic A, Theiner S, Keppler BK, Rompel A. X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism. Journal of Medicinal Chemistry. 59: 5894-903. PMID 27196130 DOI: 10.1021/Acs.Jmedchem.6B00600  0.388
2016 Henke H, Kryeziu K, Banfić J, Theiner S, Körner W, Brüggemann O, Berger W, Keppler BK, Heffeter P, Teasdale I. Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes. Macromolecular Bioscience. 16: 1239-1249. PMID 27169668 DOI: 10.1002/Mabi.201600035  0.373
2016 Göschl S, Varbanov HP, Theiner S, Jakupec MA, Galanski M, Keppler BK. The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs. Journal of Inorganic Biochemistry. 160: 264-74. PMID 27055943 DOI: 10.1016/J.Jinorgbio.2016.03.005  0.424
2016 Terenzi A, Lötsch D, van Schoonhoven S, Roller A, Kowol CR, Berger W, Keppler BK, Barone G. Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes. Dalton Transactions (Cambridge, England : 2003). 45: 7758-67. PMID 27054617 DOI: 10.1039/C6Dt00648E  0.392
2016 Bytzek AK, Koellensperger G, Keppler BK, G Hartinger C. Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action. Journal of Inorganic Biochemistry. 160: 250-5. PMID 26993078 DOI: 10.1016/J.Jinorgbio.2016.02.037  0.344
2016 Flocke LS, Trondl R, Jakupec MA, Keppler BK. Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines. Investigational New Drugs. 34: 261-8. PMID 26988975 DOI: 10.1007/S10637-016-0337-8  0.321
2016 Novak MS, Büchel GE, Keppler BK, Jakupec MA. Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 26961253 DOI: 10.1007/S00775-016-1345-Z  0.422
2016 Meier SM, Gerner C, Keppler BK, Cinellu MA, Casini A. Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects. Inorganic Chemistry. 55: 4248-59. PMID 26866307 DOI: 10.1021/Acs.Inorgchem.5B03000  0.397
2016 Schreiber-Brynzak E, Pichler V, Heffeter P, Hanson B, Theiner S, Lichtscheidl-Schultz I, Kornauth C, Bamonti L, Dhery V, Groza D, Berry D, Berger W, Galanski M, Jakupec MA, Keppler BK. Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation. Metallomics : Integrated Biometal Science. 8: 422-33. PMID 26860208 DOI: 10.1039/C5Mt00312A  0.403
2016 Theiner S, Schreiber-Brynzak E, Jakupec MA, Galanski M, Koellensperger G, Keppler BK. LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics : Integrated Biometal Science. 8: 398-402. PMID 26806253 DOI: 10.1039/C5Mt00276A  0.345
2016 Schmidlehner M, Flocke LS, Roller A, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics. Dalton Transactions (Cambridge, England : 2003). 45: 724-33. PMID 26630201 DOI: 10.1039/C5Dt02722E  0.464
2016 Pichler V, Göschl S, Schreiber-Brynzak E, Jakupec MA, Galanski M, Keppler BK. Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines. Metallomics : Integrated Biometal Science. 7: 1078-90. PMID 26073554 DOI: 10.1039/C5Mt00116A  0.409
2016 Fischer B, Kryeziu K, Kallus S, Heffeter P, Berger W, Kowol CR, Keppler BK. Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity Rsc Advances. 6: 55848-55859. DOI: 10.1039/C6Ra07659A  0.317
2016 Koellensperger G, Galanski M, Keppler BK, Hann S. Turbulent flow chromatography in combination with HPLC-ICP-MS for high-throughput analysis of free, intact metal based drugs in biomedical samples Journal of Analytical Atomic Spectrometry. 31: 1811-1817. DOI: 10.1039/C6Ja00108D  0.326
2016 Orlowska E, Roller A, Wiesinger H, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. Benzoic hydroxamate-based iron complexes as model compounds for humic substances: synthesis, characterization and algal growth experiments Rsc Advances. 6: 40238-40249. DOI: 10.1039/C5Ra25256C  0.388
2016 Galanski M, Sommerfeld N, Hejl M, Klose M, Schreiber-Brynzak E, Bileck A, Meier S, Gerner C, Jakupec M, Keppler B. Low generation PAMAM dendrimers as drug carriers for Pt(IV) complexes European Journal of Inorganic Chemistry. DOI: 10.1002/Ejic.201601205  0.351
2016 Kurzwernhart A, Mokesch S, Klapproth E, Adib‐Ravazi MS, Jakupec MA, Hartinger CG, Kandioller W, Keppler BK. Flavonoid‐Based Organometallics with Different Metal Centers – Investigations of the Effects on Reactivity and Cytotoxicity European Journal of Inorganic Chemistry. 2016: 240-246. DOI: 10.1002/Ejic.201501020  0.422
2015 Babak MV, Meier SM, Huber KVM, Reynisson J, Legin AA, Jakupec MA, Roller A, Stukalov A, Gridling M, Bennett KL, Colinge J, Berger W, Dyson PJ, Superti-Furga G, Keppler BK, et al. Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action. Chemical Science. 6: 2449-2456. PMID 29308157 DOI: 10.1039/C4Sc03905J  0.34
2015 Oehninger L, Spreckelmeyer S, Holenya P, Meier SM, Can S, Alborzinia H, Schur J, Keppler BK, Wölfl S, Ott I. Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling. Journal of Medicinal Chemistry. 58: 9591-9600. PMID 26595649 DOI: 10.1021/Acs.Jmedchem.5B01159  0.428
2015 Pelivan K, Miklos W, van Schoonhoven S, Koellensperger G, Gille L, Berger W, Heffeter P, Kowol CR, Keppler BK. Differences in protein binding and excretion of Triapine and its Fe(III) complex. Journal of Inorganic Biochemistry. PMID 26507768 DOI: 10.1016/J.Jinorgbio.2015.10.006  0.355
2015 Höfer D, Varbanov HP, Legin A, Jakupec MA, Roller A, Galanski M, Keppler BK. Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy. Journal of Inorganic Biochemistry. 153: 259-271. PMID 26365319 DOI: 10.1016/J.Jinorgbio.2015.08.018  0.482
2015 Enyedy ÉA, Mészáros JP, Dömötör O, Hackl CM, Roller A, Keppler BK, Kandioller W. Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin. Journal of Inorganic Biochemistry. 152: 93-103. PMID 26364131 DOI: 10.1016/J.Jinorgbio.2015.08.025  0.439
2015 Kowol CR, Nagy NV, Jakusch T, Roller A, Heffeter P, Keppler BK, Enyedy ÉA. Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity. Journal of Inorganic Biochemistry. 152: 62-73. PMID 26349014 DOI: 10.1016/J.Jinorgbio.2015.08.023  0.432
2015 Schreiber-Brynzak E, Klapproth E, Unger C, Lichtscheidl-Schultz I, Göschl S, Schweighofer S, Trondl R, Dolznig H, Jakupec MA, Keppler BK. Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs. Investigational New Drugs. 33: 835-47. PMID 26091914 DOI: 10.1007/S10637-015-0260-4  0.309
2015 Habala L, Bartel C, Giester G, Jakupec MA, Keppler BK, Rompel A. Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex. Journal of Inorganic Biochemistry. 147: 147-52. PMID 25920686 DOI: 10.1016/J.Jinorgbio.2015.04.004  0.455
2015 Hoffmeister BR, Hejl M, Adib-Razavi MS, Jakupec MA, Galanski M, Keppler BK. Bis- and Tetrakis(carboxylato)platinum(IV) complexes with mixed axial ligands - synthesis, characterization, and cytotoxicity. Chemistry & Biodiversity. 12: 559-574. PMID 25879501 DOI: 10.1002/Cbdv.201400291  0.443
2015 Theiner S, Kornauth C, Varbanov HP, Galanski M, Van Schoonhoven S, Heffeter P, Berger W, Egger AE, Keppler BK. Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents. Metallomics : Integrated Biometal Science. 7: 1256-64. PMID 25856224 DOI: 10.1039/C5Mt00028A  0.309
2015 Babak MV, Plażuk D, Meier SM, Arabshahi HJ, Reynisson J, Rychlik B, Błauż A, Szulc K, Hanif M, Strobl S, Roller A, Keppler BK, Hartinger CG. Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 5110-7. PMID 25676245 DOI: 10.1002/Chem.201403974  0.445
2015 Theiner S, Varbanov HP, Galanski M, Egger AE, Berger W, Heffeter P, Keppler BK. Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 20: 89-99. PMID 25413442 DOI: 10.1007/S00775-014-1214-6  0.396
2015 Enyedy ÉA, Dömötör O, Bali K, Hetényi A, Tuccinardi T, Keppler BK. Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins. Journal of Biological Inorganic Chemistry. 20: 77-88. PMID 25398250 DOI: 10.1007/S00775-014-1211-9  0.402
2015 Kuhn PS, Pichler V, Roller A, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential. Dalton Transactions (Cambridge, England : 2003). 44: 659-68. PMID 25385191 DOI: 10.1039/C4Dt01645A  0.416
2015 Kubanik M, Tu JKY, Söhnel T, Hejl M, Jakupec MA, Kandioller W, Keppler BK, Hartinger CG. Expanding on the Structural Diversity of Flavone- Derived RutheniumII(ƞ6-arene) Anticancer Agents Metallodrugs. 1. DOI: 10.1515/MEDR-2015-0001  0.367
2015 Miklos W, Pelivan K, Kowol C, Dornetshuber-Fleiss R, Spitzwieser M, Cichna-Markl M, Köllensperger G, Keppler B, Berger W, Heffeter P. Abstract 5461: Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance Cancer Research. 75: 5461-5461. DOI: 10.1158/1538-7445.Am2015-5461  0.306
2015 Heffeter P, Karnthaler-Benbakka C, Groza D, Kryeziu K, Berger W, Keppler BK, Kowol CR. Abstract 4397: Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design Cancer Research. 75: 4397-4397. DOI: 10.1158/1538-7445.Am2015-4397  0.335
2015 Alte B, Pirker C, Mohr T, Kryeziu K, Keppler BK, Heffeter P, Berger W. Abstract 2573: Investigation of factors involved in the hypersensitivity to KP1339-treatment Cancer Research. 75: 2573-2573. DOI: 10.1158/1538-7445.Am2015-2573  0.337
2015 Enyedy ÉA, Dömötör O, Hackl CM, Roller A, Novak MS, Jakupec MA, Keppler BK, Kandioller W. Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone Journal of Coordination Chemistry. DOI: 10.1080/00958972.2015.1023195  0.408
2015 Mokesch S, Novak MS, Roller A, Jakupec MA, Kandioller W, Keppler BK. 1,3-dioxoindan-2-carboxamides as bioactive ligand scaffolds for the development of novel organometallic anticancer drugs Organometallics. 34: 848-857. DOI: 10.1021/Om501032S  0.452
2015 Legin A, Theiner S, Schintlmeister A, Reipert S, Heffeter P, Jakupec M, Kowol C, Galanski M, Berger W, Wagner M, Keppler B. 702 Multiscale distribution of anticancer platinum(IV) complexes in murine samples revealed by combination of NanoSIMS, LA-ICP-MS and TEM imaging European Journal of Cancer. 51. DOI: 10.1016/S0959-8049(16)30372-0  0.307
2015 Novak M, Hackl C, Kandioller W, Jakupec M, Keppler B. 356 Targeting DNA topoisomerase IIa activity with thiomaltol-based organometallic complexes European Journal of Cancer. 51. DOI: 10.1016/S0959-8049(16)30219-2  0.325
2015 Kandioller W, Kubanik M, Bytzek AK, Jakupec MA, Roller A, Keppler BK, Hartinger CG. The rearrangement of tosylated flavones to 1′-(alkylamino)aurones with primary amines Tetrahedron. 71: 8953-8959. DOI: 10.1016/J.Tet.2015.09.062  0.321
2015 Schmidlehner M, Pichler V, Roller A, Jakupec MA, Kandioller W, Keppler BK. Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations Journal of Organometallic Chemistry. 782: 69-76. DOI: 10.1016/J.Jorganchem.2014.10.044  0.439
2015 Hoffmeister BR, Hejl M, Jakupec MA, Galanski M, Keppler BK. Bis- and Tris(carboxylato)platinum(IV) Complexes with Mixed Am(m)ine Ligands in the trans Position Exhibiting Exceptionally High Cytotoxicity European Journal of Inorganic Chemistry. 2015: 1700-1708. DOI: 10.1002/Ejic.201403226  0.393
2014 Martinčič A, Milačič R, Vidmar J, Turel I, Keppler BK, Sčančar J. New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks. Journal of Chromatography. A. 1371: 168-76. PMID 25456595 DOI: 10.1016/J.Chroma.2014.10.054  0.377
2014 Jungwirth U, Gojo J, Tuder T, Walko G, Holcmann M, Schöfl T, Nowikovsky K, Wilfinger N, Schoonhoven S, Kowol CR, Lemmens-Gruber R, Heffeter P, Keppler BK, Berger W. Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46. Molecular Cancer Therapeutics. 13: 2436-49. PMID 25082959 DOI: 10.1158/1535-7163.Mct-14-0087  0.343
2014 Varbanov HP, Göschl S, Heffeter P, Theiner S, Roller A, Jensen F, Jakupec MA, Berger W, Galanski M, Keppler BK. A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs. Journal of Medicinal Chemistry. 57: 6751-64. PMID 25032896 DOI: 10.1021/Jm500791C  0.452
2014 Hudej R, Miklavcic D, Cemazar M, Todorovic V, Sersa G, Bergamo A, Sava G, Martincic A, Scancar J, Keppler BK, Turel I. Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo. The Journal of Membrane Biology. 247: 1239-51. PMID 24957014 DOI: 10.1007/S00232-014-9696-2  0.372
2014 Hanif M, Nawaz MA, Babak MV, Iqbal J, Roller A, Keppler BK, Hartinger CG. RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition. Molecules (Basel, Switzerland). 19: 8080-92. PMID 24936709 DOI: 10.3390/Molecules19068080  0.443
2014 Meier SM, Novak MS, Kandioller W, Jakupec MA, Roller A, Keppler BK, Hartinger CG. Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent. Dalton Transactions (Cambridge, England : 2003). 43: 9851-5. PMID 24872129 DOI: 10.1039/C4Dt00569D  0.356
2014 Egger AE, Theiner S, Kornauth C, Heffeter P, Berger W, Keppler BK, Hartinger CG. Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice. Metallomics : Integrated Biometal Science. 6: 1616-25. PMID 24823867 DOI: 10.1039/C4Mt00072B  0.301
2014 Ossipov K, Scaffidi-Domianello YY, Seregina IF, Galanski M, Keppler BK, Timerbaev AR, Bolshov MA. Inductively coupled plasma mass spectrometry for metallodrug development: albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes. Journal of Inorganic Biochemistry. 137: 40-45. PMID 24803025 DOI: 10.1016/J.Jinorgbio.2014.04.008  0.389
2014 Meier SM, Babak MV, Keppler BK, Hartinger CG. Efficiently detecting metallodrug-protein adducts: ion trap versus time-of-flight mass analyzers. Chemmedchem. 9: 1351-5. PMID 24643974 DOI: 10.1002/Cmdc.201400020  0.319
2014 Dömötör O, Aicher S, Schmidlehner M, Novak MS, Roller A, Jakupec MA, Kandioller W, Hartinger CG, Keppler BK, Enyedy ÉA. Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity. Journal of Inorganic Biochemistry. 134: 57-65. PMID 24556426 DOI: 10.1016/J.Jinorgbio.2014.01.020  0.429
2014 Legin AA, Jakupec MA, Bokach NA, Tyan MR, Kukushkin VY, Keppler BK. Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions. Journal of Inorganic Biochemistry. 133: 33-9. PMID 24444821 DOI: 10.1016/J.Jinorgbio.2013.12.007  0.396
2014 Fischer B, Heffeter P, Kryeziu K, Gille L, Meier SM, Berger W, Kowol CR, Keppler BK. Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation. Dalton Transactions (Cambridge, England : 2003). 43: 1096-104. PMID 24165902 DOI: 10.1039/C3Dt52388H  0.345
2014 Legin AA, Schintlmeister A, Jakupec MA, Galanski M, Lichtscheidl I, Wagner M, Keppler BK. NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs Chemical Science. 5: 3135-3143. DOI: 10.1039/C3Sc53426J  0.315
2014 Trondl R, Heffeter P, Kowol CR, Jakupec MA, Berger W, Keppler BK. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application Chemical Science. 5: 2925-2932. DOI: 10.1039/C3Sc53243G  0.377
2014 Brynzak E, Heffeter P, Pichler V, Jakupec M, Keppler B. 156 Behaviour of platinum(IV) complexes with prodrug function in different models of hypoxia European Journal of Cancer. 50: 53. DOI: 10.1016/S0959-8049(14)70282-5  0.305
2014 Göschl S, Pichler V, Brynzak E, Heffeter P, Jungwirth U, Jakupec M, Berger W, Galanski M, Keppler B. 52 Platinum(IV) derivatives of oxaliplatin: Cellular effects and in vivo potency European Journal of Cancer. 50: 22. DOI: 10.1016/S0959-8049(14)70178-9  0.344
2014 Tamasi G, Carpini A, Valensin D, Messori L, Pratesi A, Scaletti F, Jakupec M, Keppler B, Cini R. {Ru(CO)x}-core complexes with selected azoles: Synthesis, X-ray structure, spectroscopy, DFT analysis and evaluation of cytotoxic activity against human cancer cells Polyhedron. 81: 227-237. DOI: 10.1016/J.Poly.2014.05.067  0.402
2014 Sija E, Hartinger CG, Keppler BK, Kiss T, Enyedy EA. Solution equilibrium studies of anticancer ruthenium(II)-η6- p-cymene complexes of pyridinecarboxylic acids Polyhedron. 67: 51-58. DOI: 10.1016/J.Poly.2013.08.057  0.37
2014 Schmidlehner M, Kuhn PS, Hackl CM, Roller A, Kandioller W, Keppler BK. Microwave-assisted synthesis of N-heterocycle-based organometallics Journal of Organometallic Chemistry. 772: 93-99. DOI: 10.1016/J.Jorganchem.2014.08.013  0.367
2014 Banfić J, Legin AA, Jakupec MA, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands – Synthesis, Characterization, and Cytotoxicity European Journal of Inorganic Chemistry. 2014: 484-492. DOI: 10.1002/Ejic.201301282  0.425
2013 Hanif M, Meier SM, Nazarov AA, Risse J, Legin A, Casini A, Jakupec MA, Keppler BK, Hartinger CG. Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. Frontiers in Chemistry. 1: 27. PMID 24790955 DOI: 10.3389/Fchem.2013.00027  0.45
2013 Heffeter P, Atil B, Kryeziu K, Groza D, Koellensperger G, Körner W, Jungwirth U, Mohr T, Keppler BK, Berger W. The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. European Journal of Cancer (Oxford, England : 1990). 49: 3366-75. PMID 23790465 DOI: 10.1016/J.Ejca.2013.05.018  0.352
2013 Pichler V, Göschl S, Meier SM, Roller A, Jakupec MA, Galanski M, Keppler BK. Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes. Inorganic Chemistry. 52: 8151-62. PMID 23790208 DOI: 10.1021/Ic400816G  0.417
2013 Enyedy EA, Sija E, Jakusch T, Hartinger CG, Kandioller W, Keppler BK, Kiss T. Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity. Journal of Inorganic Biochemistry. 127: 161-8. PMID 23721887 DOI: 10.1016/J.Jinorgbio.2013.05.002  0.438
2013 Meier SM, Novak M, Kandioller W, Jakupec MA, Arion VB, Metzler-Nolte N, Keppler BK, Hartinger CG. Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate Chemistry - a European Journal. 19: 9297-9307. PMID 23712572 DOI: 10.1002/Chem.201300889  0.367
2013 Grabmann G, Keppler BK, Hartinger CG. A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP). Analytical and Bioanalytical Chemistry. 405: 6417-24. PMID 23620371 DOI: 10.1007/S00216-013-6937-7  0.365
2013 Kupcewicz B, Sobiesiak K, Malinowska K, Koprowska K, Czyz M, Keppler B, Budzisz E. Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 22: 2395-2402. PMID 23542890 DOI: 10.1007/S00044-012-0233-5  0.363
2013 Kandioller W, Balsano E, Meier SM, Jungwirth U, Göschl S, Roller A, Jakupec MA, Berger W, Keppler BK, Hartinger CG. Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chemical Communications (Cambridge, England). 49: 3348-50. PMID 23505633 DOI: 10.1039/C3Cc40432C  0.411
2013 Filak LK, Göschl S, Heffeter P, Samper KG, Egger AE, Jakupec MA, Keppler BK, Berger W, Arion VB. Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation. Organometallics. 32: 903-914. PMID 23431223 DOI: 10.1021/Om3012272  0.449
2013 Pichler V, Mayr J, Heffeter P, Dömötör O, Enyedy ÉA, Hermann G, Groza D, Köllensperger G, Galanksi M, Berger W, Keppler BK, Kowol CR. Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery. Chemical Communications (Cambridge, England). 49: 2249-2251. PMID 23396381 DOI: 10.1039/C3Cc39258A  0.367
2013 Valiahdi SM, Egger AE, Miklos W, Jungwirth U, Meelich K, Nock P, Berger W, Hartinger CG, Galanski M, Jakupec MA, Keppler BK. Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 18: 249-60. PMID 23354303 DOI: 10.1007/S00775-012-0970-4  0.37
2013 Babak MV, Meier SM, Legin AA, Adib Razavi MS, Roller A, Jakupec MA, Keppler BK, Hartinger CG. Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 4308-18. PMID 23341078 DOI: 10.1002/Chem.201202657  0.47
2013 Hummer AA, Heffeter P, Berger W, Filipits M, Batchelor D, Büchel GE, Jakupec MA, Keppler BK, Rompel A. X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019). Journal of Medicinal Chemistry. 56: 1182-96. PMID 23282017 DOI: 10.1021/Jm301648F  0.358
2013 Varbanov HP, Jakupec MA, Roller A, Jensen F, Galanski M, Keppler BK. Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes. Journal of Medicinal Chemistry. 56: 330-44. PMID 23214999 DOI: 10.1021/Jm3016427  0.401
2013 Kurzwernhart A, Kandioller W, Enyedy ÉA, Novak M, Jakupec MA, Keppler BK, Hartinger CG. 3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands. Dalton Transactions (Cambridge, England : 2003). 42: 6193-202. PMID 23168616 DOI: 10.1039/C2Dt32206D  0.465
2013 Dömötör O, Hartinger CG, Bytzek AK, Kiss T, Keppler BK, Enyedy EA. Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 18: 9-17. PMID 23076343 DOI: 10.1007/S00775-012-0944-6  0.346
2013 Meier SM, Hanif M, Adhireksan Z, Pichler V, Novak M, Jirkovsky E, Jakupec MA, Arion VB, Davey CA, Keppler BK, Hartinger CG. Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents Chemical Science. 4: 1837. DOI: 10.1039/C3Sc22294B  0.449
2013 Ivanović I, Gligorijević N, Aranđelović S, Radulović S, Roller A, Keppler BK, Tešić ŽL, Grgurić-Šipka S. New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3- and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity Polyhedron. 61: 112-118. DOI: 10.1016/J.Poly.2013.05.050  0.452
2013 Schwarz MB, Kurzwernhart A, Roller A, Kandioller W, Keppler BK, Hartinger CG. Rhodium(Cp*) Compounds with Flavone‐derived Ligand Systems: Synthesis and Characterization Zeitschrift FüR Anorganische Und Allgemeine Chemie. 639: 1648-1654. DOI: 10.1002/Zaac.201300145  0.444
2013 Banfic J, Adib-Razavi MS, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring Axial (1, 4–13C2)Succinato Ligands – Synthesis, Characterization, and Preliminary ­Investigations in Cancer Cell Lysates Zeitschrift FüR Anorganische Und Allgemeine Chemie. 639: 1613-1620. DOI: 10.1002/Zaac.201300058  0.441
2012 Pichler V, Heffeter P, Valiahdi SM, Kowol CR, Egger A, Berger W, Jakupec MA, Galanski M, Keppler BK. Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity. Journal of Medicinal Chemistry. 55: 11052-61. PMID 23194425 DOI: 10.1021/Jm301645G  0.407
2012 Kurzwernhart A, Kandioller W, Bächler S, Bartel C, Martic S, Buczkowska M, Mühlgassner G, Jakupec MA, Kraatz HB, Bednarski PJ, Arion VB, Marko D, Keppler BK, Hartinger CG. Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands. Journal of Medicinal Chemistry. 55: 10512-22. PMID 23134291 DOI: 10.1021/Jm301376A  0.453
2012 Enyedy ÉA, Dömötör O, Varga E, Kiss T, Trondl R, Hartinger CG, Keppler BK. Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands. Journal of Inorganic Biochemistry. 117: 189-97. PMID 23089600 DOI: 10.1016/J.Jinorgbio.2012.08.005  0.395
2012 Ginzinger W, Egger A, Mühlgassner G, Arion VB, Jakupec MA, Galanski M, Berger W, Keppler BK. Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis. Chemistry & Biodiversity. 9: 2175-2185. PMID 23081917 DOI: 10.1002/Cbdv.201200147  0.362
2012 Mühlgassner G, Bartel C, Schmid WF, Jakupec MA, Arion VB, Keppler BK. Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells. Journal of Inorganic Biochemistry. 116: 180-7. PMID 23037896 DOI: 10.1016/J.Jinorgbio.2012.06.003  0.408
2012 Hoffmeister BR, Adib-Razavi MS, Jakupec MA, Galanski M, Keppler BK. Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity. Chemistry & Biodiversity. 9: 1840-1848. PMID 22976974 DOI: 10.1002/Cbdv.201200019  0.408
2012 Henke H, Kandioller W, Hanif M, Keppler BK, Hartinger CG. Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents. Chemistry & Biodiversity. 9: 1718-27. PMID 22976964 DOI: 10.1002/Cbdv.201200005  0.426
2012 Grabmann G, Meier SM, Scaffidi-Domianello YY, Galanski M, Keppler BK, Hartinger CG. Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions. Journal of Chromatography. A. 1267: 156-61. PMID 22897861 DOI: 10.1016/J.Chroma.2012.07.062  0.4
2012 Milunovic MN, Enyedy É, Nagy NV, Kiss T, Trondl R, Jakupec MA, Keppler BK, Krachler R, Novitchi G, Arion VB. L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity. Inorganic Chemistry. 51: 9309-21. PMID 22889304 DOI: 10.1021/Ic300967J  0.391
2012 Varbanov HP, Valiahdi SM, Kowol CR, Jakupec MA, Galanski M, Keppler BK. Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs Dalton Transactions. 41: 14404-14415. PMID 22886297 DOI: 10.1039/C2Dt31366A  0.476
2012 Arion VB, Dobrov A, Göschl S, Jakupec MA, Keppler BK, Rapta P. Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs. Chemical Communications. 48: 8559-8561. PMID 22797078 DOI: 10.1039/C2Cc33786J  0.404
2012 Scaffidi-Domianello YY, Legin AA, Jakupec MA, Roller A, Kukushkin VY, Galanski M, Keppler BK. Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies. Inorganic Chemistry. 51: 7153-63. PMID 22691006 DOI: 10.1021/Ic300148E  0.358
2012 Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Keppler BK, Heffeter P, Berger W, Arion VB. Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity. Journal of Inorganic Biochemistry. 113: 47-54. PMID 22687494 DOI: 10.1016/J.Jinorgbio.2012.04.001  0.355
2012 Hummer AA, Bartel C, Arion VB, Jakupec MA, Meyer-Klaucke W, Geraki T, Quinn PD, Mijovilovich A, Keppler BK, Rompel A. X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue. Journal of Medicinal Chemistry. 55: 5601-13. PMID 22621452 DOI: 10.1021/Jm3005459  0.343
2012 Kurzwernhart A, Kandioller W, Bartel C, Bächler S, Trondl R, Mühlgassner G, Jakupec MA, Arion VB, Marko D, Keppler BK, Hartinger CG. Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder. Chemical Communications (Cambridge, England). 48: 4839-41. PMID 22498692 DOI: 10.1039/C2Cc31040F  0.346
2012 Buß I, Kalayda GV, Lindauer A, Reithofer MR, Galanski M, Keppler BK, Jaehde U. Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 699-708. PMID 22456982 DOI: 10.1007/S00775-012-0889-9  0.377
2012 Heffeter P, Pirker C, Kowol CR, Herrman G, Dornetshuber R, Miklos W, Jungwirth U, Koellensperger G, Keppler BK, Berger W. Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones Biochemical Pharmacology. 83: 1623-1633. PMID 22426010 DOI: 10.1016/J.Bcp.2012.03.004  0.335
2012 Meier SM, Hanif M, Kandioller W, Keppler BK, Hartinger CG. Biomolecule binding vs. anticancer activity: reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins. Journal of Inorganic Biochemistry. 108: 91-5. PMID 22420927 DOI: 10.1016/J.Jinorgbio.2011.08.011  0.422
2012 Ginzinger W, Mühlgassner G, Arion VB, Jakupec MA, Roller A, Galanski M, Reithofer M, Berger W, Keppler BK. A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines Journal of Medicinal Chemistry. 55: 3398-3413. PMID 22417128 DOI: 10.1021/Jm3000906  0.475
2012 Jungwirth U, Xanthos DN, Gojo J, Bytzek AK, Körner W, Heffeter P, Abramkin SA, Jakupec MA, Hartinger CG, Windberger U, Galanski M, Keppler BK, Berger W. Anticancer activity of methyl-substituted oxaliplatin analogs. Molecular Pharmacology. 81: 719-28. PMID 22331606 DOI: 10.1124/Mol.111.077321  0.339
2012 Abramkin S, Valiahdi SM, Jakupec MA, Galanski M, Metzler-Nolte N, Keppler BK. Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates Dalton Transactions. 41: 3001-3005. PMID 22281694 DOI: 10.1039/C2Dt12024K  0.325
2012 Bartel C, Bytzek AK, Scaffidi-Domianello YY, Grabmann G, Jakupec MA, Hartinger CG, Galanski M, Keppler BK. Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 465-74. PMID 22227950 DOI: 10.1007/S00775-011-0869-5  0.415
2012 Kowol CR, Heffeter P, Miklos W, Gille L, Trondl R, Cappellacci L, Berger W, Keppler BK. Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds. Journal of Biological Inorganic Chemistry. 17: 409-423. PMID 22189939 DOI: 10.1007/S00775-011-0864-X  0.377
2012 Hanif M, Nazarov AA, Legin A, Groessl M, Arion VB, Jakupec MA, Tsybin YO, Dyson PJ, Keppler BK, Hartinger CG. Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules. Chemical Communications (Cambridge, England). 48: 1475-7. PMID 22003496 DOI: 10.1039/C1Cc14713G  0.365
2012 Trondl R, Heffeter P, Jakupec MA, Berger W, Keppler BK. NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer Bmc Clinical Pharmacology. 13: 1-1. DOI: 10.1186/2050-6511-13-S1-A82  0.352
2012 Hudej R, Kljun J, Kandioller W, Repnik U, Turk B, Hartinger CG, Keppler BK, Miklavčič D, Turel I. Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex Organometallics. 31: 5867-5874. DOI: 10.1021/Om300424W  0.435
2012 Gavrish SP, Lampeka YD, Lightfoot P, Arion VB, Keppler BK, Woźniak K. Solid State Structural Variations in Copper(II) Complexes of Open-Chain and Macrocyclic Malonamide-Derived Ligands Crystal Growth & Design. 12: 4388-4396. DOI: 10.1021/Cg300554R  0.401
2012 Novak M, Büchel G, Gavriluta A, Tommasino J, Luneau D, Jakupec M, Arion V, Keppler B. 523 Biological Effects of Ruthenium and Osmium Nitrosyl Complexes with Azole Heterocycles European Journal of Cancer. 48: 161. DOI: 10.1016/S0959-8049(12)72320-1  0.382
2012 Göschl S, Filak LK, Egger A, Jakupec MA, Keppler BK, Arion VB. 271 In Vitro Studies of Novel Ruthenium(II) and Osmium(II) Indoloquinoline Complexes European Journal of Cancer. 48: 83-84. DOI: 10.1016/S0959-8049(12)72069-5  0.371
2012 Enyedy EA, Zsigõ E, Nagy NV, Kowol CR, Roller A, Keppler BK, Kiss T. Complex-formation ability of salicylaldehyde thiosemicarbazone towards Zn II, Cu II, Fe II, Fe III and Ga III ions European Journal of Inorganic Chemistry. 4036-4047. DOI: 10.1002/Ejic.201200360  0.428
2011 Stepanenko IN, Casini A, Edafe F, Novak MS, Arion VB, Dyson PJ, Jakupec MA, Keppler BK. Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells. Inorganic Chemistry. 50: 12669-79. PMID 22111668 DOI: 10.1021/Ic201801E  0.388
2011 Scaffidi-Domianello YY, Legin AA, Jakupec MA, Arion VB, Kukushkin VY, Galanski M, Keppler BK. Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands. Inorganic Chemistry. 50: 10673-81. PMID 21951170 DOI: 10.1021/Ic2010612  0.411
2011 Varbanov H, Valiahdi SM, Legin AA, Jakupec MA, Roller A, Galanski M, Keppler BK. Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin European Journal of Medicinal Chemistry. 46: 5456-5464. PMID 21940073 DOI: 10.1016/J.Ejmech.2011.09.006  0.454
2011 Bytzek AK, Boeck K, Hermann G, Hann S, Keppler BK, Hartinger CG, Koellensperger G. LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma. Metallomics : Integrated Biometal Science. 3: 1049-55. PMID 21935553 DOI: 10.1039/C1Mt00055A  0.33
2011 Pichler V, Valiahdi SM, Jakupec MA, Arion VB, Galanski M, Keppler BK. Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity. Dalton Transactions (Cambridge, England : 2003). 40: 8187-92. PMID 21743934 DOI: 10.1039/C1Dt10301F  0.439
2011 Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Keppler BK, Arion VB. En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]. Inorganic Chemistry. 50: 7690-7. PMID 21739939 DOI: 10.1021/Ic200728B  0.417
2011 Bartel C, Egger AE, Jakupec MA, Heffeter P, Galanski M, Berger W, Keppler BK. Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. Journal of Biological Inorganic Chemistry. 16: 1205-1215. PMID 21706338 DOI: 10.1007/S00775-011-0809-4  0.382
2011 Enyedy EA, Horváth L, Hetényi A, Tuccinardi T, Hartinger CG, Keppler BK, Kiss T. Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies. Bioorganic & Medicinal Chemistry. 19: 4202-10. PMID 21696966 DOI: 10.1016/J.Bmc.2011.05.063  0.356
2011 Kljun J, Bytzek AK, Kandioller W, Bartel C, Jakupec MA, Hartinger CG, Keppler BK, Turel I. Physicochemical Studies and Anticancer Potency of Ruthenium η-p-Cymene Complexes Containing Antibacterial Quinolones. Organometallics. 30: 2506-2512. PMID 21552495 DOI: 10.1021/Om101180C  0.428
2011 Enyedy ÉA, Primik MF, Kowol CR, Arion VB, Kiss T, Keppler BK. Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. Dalton Transactions (Cambridge, England : 2003). 40: 5895-905. PMID 21523301 DOI: 10.1039/C0Dt01835J  0.398
2011 Buss I, Garmann D, Galanski M, Weber G, Kalayda GV, Keppler BK, Jaehde U. Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes? Journal of Inorganic Biochemistry. 105: 709-17. PMID 21450275 DOI: 10.1016/J.Jinorgbio.2011.02.005  0.348
2011 Foteeva LS, Trofimov DA, Kuznetsova OV, Kowol CR, Arion VB, Keppler BK, Timerbaev AR. A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography Journal of Pharmaceutical and Biomedical Analysis. 55: 409-413. PMID 21382684 DOI: 10.1016/J.Jpba.2011.02.011  0.359
2011 Jungwirth U, Kowol CR, Keppler BK, Hartinger CG, Berger W, Heffeter P. Anticancer activity of metal complexes: involvement of redox processes. Antioxidants & Redox Signaling. 15: 1085-127. PMID 21275772 DOI: 10.1089/Ars.2010.3663  0.349
2011 Filak LK, Mühlgassner G, Bacher F, Roller A, Galanski M, Jakupec MA, Keppler BK, Arion VB. Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity. Organometallics. 30: 273-283. PMID 21253447 DOI: 10.1021/Om101004Z  0.373
2011 Hanif M, Meier SM, Kandioller W, Bytzek A, Hejl M, Hartinger CG, Nazarov AA, Arion VB, Jakupec MA, Dyson PJ, Keppler BK. From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands. Journal of Inorganic Biochemistry. 105: 224-31. PMID 21194622 DOI: 10.1016/J.Jinorgbio.2010.10.004  0.462
2011 Reithofer MR, Bytzek AK, Valiahdi SM, Kowol CR, Groessl M, Hartinger CG, Jakupec MA, Galanski M, Keppler BK. Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes. Journal of Inorganic Biochemistry. 105: 46-51. PMID 21134601 DOI: 10.1016/J.Jinorgbio.2010.09.006  0.419
2011 Bippus P, Skocic M, Jakupec MA, Keppler BK, Mohr F. Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates. Journal of Inorganic Biochemistry. 105: 462-6. PMID 20864176 DOI: 10.1016/J.Jinorgbio.2010.08.010  0.372
2011 Pashkunova-Martic I, Kremser C, Galanski M, Schluga P, Arion V, Debbage P, Jaschke W, Keppler B. Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers. Molecular Imaging and Biology. 13: 432-442. PMID 20574850 DOI: 10.1007/S11307-010-0358-1  0.331
2011 Kratz F, Keppler BK, Messori L, Smith C, Baker EN. Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin. Metal-Based Drugs. 1: 169-73. PMID 18476228 DOI: 10.1155/Mbd.1994.169  0.427
2011 Pieper T, Peti W, Keppler BK. Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III). Metal-Based Drugs. 7: 225-32. PMID 18475949 DOI: 10.1155/Mbd.2000.225  0.432
2011 Ivanovic I, Grguric-Sipka S, Gligorijevic N, Radulovic SS, Roller A, Tesic ZL, Keppler B. X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex Journal of the Serbian Chemical Society. 76: 53-61. DOI: 10.2298/Jsc100517017I  0.437
2011 Heffeter P, Atil B, Kryeziu K, Jungwirth U, Gal E, Keppler BK, Berger W. Abstract 3541: Combination of the ruthenium compound KP1339 with the tyrosine kinase inhibitor sorafenib: A promising approach for the treatment of human hepatoma Cancer Research. 71: 3541-3541. DOI: 10.1158/1538-7445.Am2011-3541  0.323
2011 Trondl R, Jungwirth U, Heffeter P, Kowol CR, Arion VB, Jakupec MA, Keppler BK. Abstract 2637: Terminal dimethyl substitution of Triapine leads to activation of CHOP and induction of apoptosis via ER stress in human colon cancer cells Cancer Research. 71: 2637-2637. DOI: 10.1158/1538-7445.Am2011-2637  0.321
2011 Kandioller W, Kurzwernhart A, Hanif M, Meier SM, Henke H, Keppler BK, Hartinger CG. Pyrone derivatives and metals: From natural products to metal-based drugs Journal of Organometallic Chemistry. 696: 999-1010. DOI: 10.1016/J.Jorganchem.2010.11.010  0.3
2011 Apfel U, Kowol CR, Kloss F, Görls H, Keppler BK, Weigand W. Hydroxy and ether functionalized dithiolanes: Models for the active site of the [FeFe] hydrogenase Journal of Organometallic Chemistry. 696: 1084-1088. DOI: 10.1016/J.Jorganchem.2010.09.048  0.315
2010 Primik MF, Göschl S, Jakupec MA, Roller A, Keppler BK, Arion VB. Structure−Activity Relationships of Highly Cytotoxic Copper(II) Complexes with Modified Indolo[3,2-c]quinoline Ligands Inorganic Chemistry. 49: 11084-11095. PMID 20979395 DOI: 10.1021/Ic101633Z  0.345
2010 Abramkin SA, Jungwirth U, Valiahdi SM, Dworak C, Habala L, Meelich K, Berger W, Jakupec MA, Hartinger CG, Nazarov AA, Galanski M, Keppler BK. {(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo. Journal of Medicinal Chemistry. 53: 7356-64. PMID 20886814 DOI: 10.1021/Jm100953C  0.344
2010 Hanif M, Henke H, Meier SM, Martic S, Labib M, Kandioller W, Jakupec MA, Arion VB, Kraatz HB, Keppler BK, Hartinger CG. Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter? Inorganic Chemistry. 49: 7953-63. PMID 20704358 DOI: 10.1021/Ic1009785  0.462
2010 Hanif M, Nazarov AA, Hartinger CG, Kandioller W, Jakupec MA, Arion VB, Dyson PJ, Keppler BK. Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences. Dalton Transactions (Cambridge, England : 2003). 39: 7345-52. PMID 20601976 DOI: 10.1039/C003085F  0.437
2010 Scaffidi-Domianello YY, Meelich K, Jakupec MA, Arion VB, Kukushkin VY, Galanski M, Keppler BK. Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity. Inorganic Chemistry. 49: 5669-78. PMID 20459062 DOI: 10.1021/Ic100584B  0.427
2010 Tamasi G, Casolaro M, Magnani A, Sega A, Chiasserini L, Messori L, Gabbiani C, Valiahdi SM, Jakupec MA, Keppler BK, Hursthouse MB, Cini R. New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro. Journal of Inorganic Biochemistry. 104: 799-814. PMID 20447694 DOI: 10.1016/J.Jinorgbio.2010.03.010  0.393
2010 Filak LK, Mühlgassner G, Jakupec MA, Heffeter P, Berger W, Arion VB, Keppler BK. Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. Journal of Biological Inorganic Chemistry. 15: 903-918. PMID 20369265 DOI: 10.1007/S00775-010-0653-Y  0.368
2010 Djinovic VM, Galanski M, Arion VB, Keppler BK. Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes. Dalton Transactions. 39: 3633-3643. PMID 20354616 DOI: 10.1039/B926133H  0.367
2010 Bytzek AK, Reithofer MR, Galanski M, Groessl M, Keppler BK, Hartinger CG. The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes. Electrophoresis. 31: 1144-50. PMID 20349510 DOI: 10.1002/Elps.200900522  0.361
2010 Heffeter P, Böck K, Atil B, Reza Hoda MA, Körner W, Bartel C, Jungwirth U, Keppler BK, Micksche M, Berger W, Koellensperger G. Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 737-48. PMID 20221888 DOI: 10.1007/S00775-010-0642-1  0.358
2010 Groessl M, Tsybin YO, Hartinger CG, Keppler BK, Dyson PJ. Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 677-88. PMID 20213306 DOI: 10.1007/S00775-010-0635-0  0.307
2010 Kowol CR, Trondl R, Arion VB, Jakupec MA, Lichtscheidl I, Keppler BK. Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex. Dalton Transactions. 39: 704-706. PMID 20066211 DOI: 10.1039/B919119B  0.318
2010 Grgurić-Šipka S, Ivanović I, Rakić G, Todorović N, Gligorijević N, Radulović S, Arion VB, Keppler BK, Tešić ŽL. Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity European Journal of Medicinal Chemistry. 45: 1051-1058. PMID 20053483 DOI: 10.1016/J.Ejmech.2009.11.055  0.42
2010 Primik MF, Mühlgassner G, Jakupec MA, Zava O, Dyson PJ, Arion VB, Keppler BK. Highly cytotoxic copper(II) complexes with modified paullone ligands. Inorganic Chemistry. 49: 302-11. PMID 19968251 DOI: 10.1021/Ic902042A  0.402
2010 Trondl R, Kowol CR, Arion VB, Jakupec MA, Keppler BK. α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation Bmc Pharmacology. 10: 1-1. DOI: 10.1186/1471-2210-10-S1-A20  0.335
2010 Hanif M, Schaaf P, Kandioller W, Hejl M, Jakupec MA, Roller A, Keppler BK, Hartinger CG. Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)–(η6-Arene) Complexes Australian Journal of Chemistry. 63: 1521-1528. DOI: 10.1071/Ch10232  0.46
2010 Jungwirth U, Heffeter P, Gojo J, Abramkin S, Meelich K, Körner W, Micksche M, Galanski M, Keppler BK, Berger W. 447 Stereoisomerism significantly impacts on the anticancer activity of novel oxaliplatin analogues in vitro and in vivo Ejc Supplements. 8: 141. DOI: 10.1016/S1359-6349(10)72154-6  0.3
2010 Kasser JH, Kandioller W, Hartinger CG, Nazarov AA, Arion VB, Dyson PJ, Keppler BK. Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability Journal of Organometallic Chemistry. 695: 875-881. DOI: 10.1016/J.Jorganchem.2010.01.007  0.439
2010 Apfel U, Kowol CR, Morera E, Görls H, Lucente G, Keppler BK, Weigand W. Synthetic and Electrochemical Studies of [2Fe2S] Complexes Containing a 4-Amino-1,2-dithiolane-4-carboxylic Acid Moiety European Journal of Inorganic Chemistry. 2010: 5079-5086. DOI: 10.1002/Ejic.201000619  0.362
2010 Enyedy ÉA, Nagy NV, Zsigó É, Kowol CR, Arion VB, Keppler BK, Kiss T. Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3‐Aminopyridine‐2‐carbaldehyde Thiosemicarbazone) and Related Ligands European Journal of Inorganic Chemistry. 2010: 1717-1728. DOI: 10.1002/Ejic.200901174  0.4
2009 Egger AE, Rappel C, Jakupec MA, Hartinger CG, Heffeter P, Keppler BK. Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells. Journal of Analytical Atomic Spectrometry. 24: 51-61. PMID 22723721 DOI: 10.1039/B810481F  0.345
2009 Schuh E, Valiahdi SM, Jakupec MA, Keppler BK, Chiba P, Mohr F. Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes. Dalton Transactions (Cambridge, England : 2003). 10841-5. PMID 20023914 DOI: 10.1039/B911234K  0.391
2009 Biba F, Groessl M, Egger A, Jakupec MA, Keppler BK. A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity Chemistry & Biodiversity. 6: 2153-2165. PMID 20020447 DOI: 10.1002/Cbdv.200900011  0.423
2009 Bytzek AK, Enyedy EA, Kiss T, Keppler BK, Hartinger CG. Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS. Electrophoresis. 30: 4075-82. PMID 19960475 DOI: 10.1002/Elps.200900212  0.362
2009 Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Arion VB, Keppler BK. [Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity. Inorganic Chemistry. 48: 10737-47. PMID 19842663 DOI: 10.1021/Ic901671J  0.432
2009 Kandioller W, Hartinger CG, Nazarov AA, Bartel C, Skocic M, Jakupec MA, Arion VB, Keppler BK. Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 12283-91. PMID 19821465 DOI: 10.1002/Chem.200901939  0.471
2009 Bergamo A, Masi A, Jakupec MA, Keppler BK, Sava G. Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion Metal-Based Drugs. 2009: 681270-681270. PMID 19789639 DOI: 10.1155/2009/681270  0.347
2009 Apfel UP, Kowol CR, Halpin Y, Kloss F, Kübel J, Görls H, Vos JG, Keppler BK, Morera E, Lucente G, Weigand W. Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects. Journal of Inorganic Biochemistry. 103: 1236-44. PMID 19664823 DOI: 10.1016/J.Jinorgbio.2009.07.005  0.313
2009 Kowol CR, Trondl R, Heffeter P, Arion VB, Jakupec MA, Roller A, Galanski M, Berger W, Keppler BK. Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation. Journal of Medicinal Chemistry. 52: 5032-5043. PMID 19637923 DOI: 10.1021/Jm900528D  0.466
2009 Valiahdi SM, Heffeter P, Jakupec MA, Marculescu R, Berger W, Rappersberger K, Keppler BK. The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines Melanoma Research. 19: 283-293. PMID 19584767 DOI: 10.1097/Cmr.0B013E32832B272D  0.34
2009 Heffeter P, Popovic-Bijelic A, Saiko P, Dornetshuber R, Jungwirth U, Voevodskaya N, Biglino D, Jakupec MA, Elbling L, Micksche M, Szekeres T, Keppler BK, Gräslund A, Berger W. Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772). Current Cancer Drug Targets. 9: 595-607. PMID 19508176 DOI: 10.2174/156800909789056962  0.328
2009 Grguric-Sipka S, Stepanenko IN, Lazic JM, Bartel C, Jakupec MA, Arion VB, Keppler BK. Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. Dalton Transactions. 3334-9. PMID 19421637 DOI: 10.1039/B822725J  0.423
2009 Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK. Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. Journal of Medicinal Chemistry. 52: 916-25. PMID 19170599 DOI: 10.1021/Jm8013234  0.447
2009 Nováková O, Nazarov AA, Hartinger CG, Keppler BK, Brabec V. DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media Biochemical Pharmacology. 77: 364-374. PMID 19014908 DOI: 10.1016/J.Bcp.2008.10.021  0.405
2009 Jungwirth U, Heffeter P, Gojo J, Abramkin S, Meelich K, Galanski M, Körner W, Micksche MM, Keppler BK, Berger W. Abstract C93: Novel monosubstituted oxaliplatin analogs with improved characteristics Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C93  0.352
2009 Heffeter P, Atil B, Jungwirth U, Koerner W, Micksche M, Keppler BK, Berger W. Abstract C103: In vitro and in vivo anticancer activity of the new ruthenium compound KP1339 against human liver cancer models Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C103  0.34
2009 Trondl R, Kowol CR, Arion VB, Jakupec MA, Lichtscheidl I, Keppler BK. Abstract C101: Subcellular distribution study by means of the inherent fluorescence of the investigational drug Triapine and its zinc(II) complex Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C101  0.401
2009 Fleischer A, Roller A, Arion VB, Keppler BK, Mohr F. Synthesis and structures of palladium(II) and platinum(II) complexes containing heterocyclic thiolate ligands formed by cycloaddition reactions of coordinated azides Canadian Journal of Chemistry. 87: 146-150. DOI: 10.1139/V08-115  0.36
2009 Mendoza-Ferri MG, Hartinger CG, Nazarov AA, Eichinger RE, Jakupec MA, Severin K, Keppler BK. Influence of the arene ligand, the number and type of metal centers, and the leaving group on the in vitro antitumor activity of polynuclear organometallic compounds Organometallics. 28: 6260-6265. DOI: 10.1021/Om900715J  0.424
2009 Kandioller W, Hartinger CG, Nazarov AA, Kuznetsov ML, John RO, Bartel C, Jakupec MA, Arion VB, Keppler BK. From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro Organometallics. 28: 4249-4251. DOI: 10.1021/Om900483T  0.375
2009 Renfrew AK, Phillips AD, Egger AE, Hartinger CG, Bosquain SS, Nazarov AA, Keppler BK, Gonsalvi L, Peruzzini M, Dyson PJ. Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta Organometallics. 28: 1165-1172. DOI: 10.1021/Om800899E  0.402
2009 Kandioller W, Hartinger CG, Nazarov AA, Kasser J, John R, Jakupec MA, Arion VB, Dyson PJ, Keppler BK. Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety Journal of Organometallic Chemistry. 694: 922-929. DOI: 10.1016/J.Jorganchem.2008.10.016  0.446
2009 Biba F, Groessl M, Egger A, Roller A, Hartinger CG, Keppler BK. New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10-phenanthroline)tris(thiocyanato-κN)lanthanum(III) (KP772) and Its Interaction with Biomolecules European Journal of Inorganic Chemistry. 2009: 4282-4287. DOI: 10.1002/Ejic.200900038  0.44
2008 Kowol CR, Reisner E, Chiorescu I, Arion VB, Galanski M, Deubel DV, Keppler BK. An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent α-N-heterocyclic chalcogensemicarbazones Inorganic Chemistry. 47: 11032-11047. PMID 18973290 DOI: 10.1021/Ic8013249  0.61
2008 Reithofer MR, Valiahdi SM, Galanski M, Jakupec MA, Arion VB, Keppler BK. Novel Endothall‐Containing Platinum(IV) Complexes: Synthesis, Characterization, and Cytotoxic Activity Chemistry & Biodiversity. 5: 2160-2170. PMID 18972539 DOI: 10.1002/Cbdv.200890197  0.414
2008 Ashraf SM, Kandioller W, Mendoza-Ferri M, Nazarov AA, Hartinger CG, Keppler BK. The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru II - and Os II -Arene Complexes Chemistry & Biodiversity. 5: 2060-2066. PMID 18972538 DOI: 10.1002/Cbdv.200890188  0.407
2008 Hartinger CG, Jakupec MA, Zorbas-Seifried S, Groessl M, Egger A, Berger W, Zorbas H, Dyson PJ, Keppler BK. KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients. Chemistry & Biodiversity. 5: 2140-55. PMID 18972504 DOI: 10.1002/Cbdv.200890195  0.331
2008 Hartinger CG, Nazarov AA, Ashraf SM, Dyson PJ, Keppler BK. Carbohydrate-metal complexes and their potential as anticancer agents. Current Medicinal Chemistry. 15: 2574-91. PMID 18855680 DOI: 10.2174/092986708785908978  0.425
2008 Reithofer MR, Schwarzinger A, Valiahdi SM, Galanski M, Jakupec MA, Keppler BK. Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity. Journal of Inorganic Biochemistry. 102: 2072-2077. PMID 18755512 DOI: 10.1016/J.Jinorgbio.2008.07.006  0.41
2008 Ashraf SM, Berger I, Nazarov AA, Hartinger CG, Koroteev MP, Nifant'ev EE, Keppler BK. Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles. short communication. Chemistry & Biodiversity. 5: 1640-1644. PMID 18729099 DOI: 10.1002/Cbdv.200890151  0.378
2008 Egger A, Cebrián‐Losantos B, Stepanenko IN, Krokhin AA, Eichinger R, Jakupec MA, Arion VB, Keppler BK. Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication. Chemistry & Biodiversity. 5: 1588-1593. PMID 18729098 DOI: 10.1002/Cbdv.200890146  0.44
2008 Groessl M, Hartinger CG, Połeć-Pawlak K, Jarosz M, Dyson PJ, Keppler BK. Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication. Chemistry & Biodiversity. 5: 1609-14. PMID 18729095 DOI: 10.1002/Cbdv.200890148  0.392
2008 Dolfen D, Schottler K, Valiahdi SM, Jakupec MA, Keppler BK, Tiekink ER, Mohr F. Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters. Journal of Inorganic Biochemistry. 102: 2067-71. PMID 18707761 DOI: 10.1016/J.Jinorgbio.2008.07.002  0.447
2008 Berger I, Hanif M, Nazarov AA, Hartinger CG, John RO, Kuznetsov ML, Groessl M, Schmitt F, Zava O, Biba F, Arion VB, Galanski M, Jakupec MA, Juillerat-Jeanneret L, Dyson PJ, ... Keppler BK, et al. In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 9046-57. PMID 18688905 DOI: 10.1002/Chem.200801032  0.423
2008 Scolaro C, Hartinger CG, Allardyce CS, Keppler BK, Dyson PJ. Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)]. Journal of Inorganic Biochemistry. 102: 1743-8. PMID 18582946 DOI: 10.1016/J.Jinorgbio.2008.05.004  0.35
2008 Cebrián-Losantos B, Reisner E, Kowol CR, Roller A, Shova S, Arion VB, Keppler BK. Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-. Inorganic Chemistry. 47: 6513-23. PMID 18553904 DOI: 10.1021/Ic800506G  0.629
2008 Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK. Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma Electrophoresis. 29: 2224-2232. PMID 18512673 DOI: 10.1002/Elps.200780790  0.342
2008 Połeć-Pawlak K, Abramski JK, Ferenc J, Foteeva LS, Timerbaev AR, Keppler BK, Jarosz M. Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins. Journal of Chromatography A. 1192: 323-326. PMID 18433763 DOI: 10.1016/J.Chroma.2008.04.009  0.349
2008 Heffeter P, Jungwirth U, Jakupec M, Hartinger C, Galanski M, Elbling L, Micksche M, Keppler B, Berger W. Resistance against novel anticancer metal compounds: Differences and similarities Drug Resistance Updates. 11: 1-16. PMID 18394950 DOI: 10.1016/J.Drup.2008.02.002  0.327
2008 Reithofer MR, Galanski M, Arion VB, Keppler BK. Unprecedented twofold intramolecular hydroamination in diam(m)ine-dicarboxylatodichloridoplatinum(IV) complexes - ethane-1,2-diamine vs. ammine ligands. Chemical Communications. 1091-3. PMID 18292900 DOI: 10.1039/B715680D  0.365
2008 Jakupec MA, Galanski M, Arion VB, Hartinger CG, Keppler BK. Antitumour metal compounds: more than theme and variations. Dalton Transactions. 183-94. PMID 18097483 DOI: 10.1039/B712656P  0.411
2008 Dorcier A, Hartinger CG, Scopelliti R, Fish RH, Keppler BK, Dyson PJ. Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds Journal of Inorganic Biochemistry. 102: 1066-1076. PMID 18086499 DOI: 10.1016/J.Jinorgbio.2007.10.016  0.392
2008 Ginzinger W, Arion VB, Giester G, Galanski M, Keppler BK. Synthesis and structural peculiarities of gallium Complexes with novel paullone derivatives Central European Journal of Chemistry. 6: 340-346. DOI: 10.2478/S11532-008-0048-X  0.401
2008 Schuecker R, John RO, Jakupec MA, Arion VB, Keppler BK. Water-Soluble Mixed-Ligand Ruthenium(II) and Osmium(II) Arene Complexes with High Antiproliferative Activity Organometallics. 27: 6587-6595. DOI: 10.1021/Om800774T  0.392
2008 Mendoza-Ferri MG, Hartinger CG, Eichinger RE, Stolyarova N, Severin K, Jakupec MA, Nazarov AA, Keppler BK. Influence of the spacer length on the in vitro anticancer activity of dinuclear ruthenium arene compounds Organometallics. 27: 2405-2407. DOI: 10.1021/Om800207T  0.378
2008 Chiorescu I, Deubel DV, Ariotn VB, Keppler BK. Computational electrochemistry of ruthenium anticancer agents. Unprecedented benchmarking of implicit solvation methods Journal of Chemical Theory and Computation. 4: 499-506. DOI: 10.1021/Ct700247G  0.373
2008 Habala L, Dworak C, Nazarov AA, Hartinger CG, Abramkin SA, Arion VB, Lindner W, Galanski M, Keppler BK. Methyl-substituted trans-1,2-cyclohexanediamines as new ligands for oxaliplatin-type complexes Tetrahedron. 64: 137-146. DOI: 10.1016/J.Tet.2007.10.069  0.37
2008 Reisner E, Arion VB, Keppler BK, Pombeiro AJ. Electron-transfer activated metal-based anticancer drugs Inorganica Chimica Acta. 361: 1569-1583. DOI: 10.1016/J.Ica.2006.12.005  0.588
2008 Dobrov A, Arion VB, Shova S, Roller A, Rentschler E, Keppler BK. Spontaneous resolution of a triple-stranded dinickel(II) helicate generated via intermolecular transamination reaction of S-methylisothiocarbohydrazide in the presence of Ni2+ European Journal of Inorganic Chemistry. 4140-4145. DOI: 10.1002/Ejic.200800605  0.327
2008 Mendoza-Ferri MG, Hartinger CG, Nazarov AA, Kandioller W, Severin K, Keppler BK. Modifying the structure of dinuclear ruthenium complexes with antitumor activity Applied Organometallic Chemistry. 22: 326-332. DOI: 10.1002/Aoc.1394  0.451
2007 Groessl M, Hartinger CG, Dyson PJ, Keppler BK. CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP. Journal of Inorganic Biochemistry. 102: 1060-5. PMID 18222004 DOI: 10.1016/J.Jinorgbio.2007.11.018  0.353
2007 Reithofer MR, Valiahdi SM, Jakupec MA, Arion VB, Egger A, Galanski M, Keppler BK. Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination Journal of Medicinal Chemistry. 50: 6692-6699. PMID 18031001 DOI: 10.1021/Jm070897B  0.441
2007 Schmid WF, John RO, Mühlgassner G, Heffeter P, Jakupec MA, Galanski M, Berger W, Arion VB, Keppler BK. Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy. Journal of Medicinal Chemistry. 50: 6343-55. PMID 17997519 DOI: 10.1021/Jm701042W  0.428
2007 Scolaro C, Chaplin AB, Hartinger CG, Bergamo A, Cocchietto M, Keppler BK, Sava G, Dyson PJ. Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy. Dalton Transactions (Cambridge, England : 2003). 5065-72. PMID 17992291 DOI: 10.1039/B705449A  0.377
2007 Hartinger CG, Keppler BK. CE in anticancer metallodrug research--an update. Electrophoresis. 28: 3436-3446. PMID 17847132 DOI: 10.1002/Elps.200700114  0.36
2007 Kowol CR, Eichinger R, Jakupec MA, Galanski M, Arion VB, Keppler BK. Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones. Journal of Inorganic Biochemistry. 101: 1946-1957. PMID 17825917 DOI: 10.1016/J.Jinorgbio.2007.07.026  0.358
2007 Gelmboldt VO, Ganin EV, Fonari MS, Simonov YA, Koroeva LV, Ennan AA, Basok SS, Shova S, Kählig H, Arion VB, Keppler BK. Two new “onium” fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties Dalton Transactions. 2007: 2915-2924. PMID 17607406 DOI: 10.1039/B703645K  0.306
2007 Timerbaev AR, Foteeva LS, Rudnev AV, Abramski JK, Połeć‐Pawlak K, Hartinger CG, Jarosz M, Keppler BK. Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE. Electrophoresis. 28: 2235-2240. PMID 17557359 DOI: 10.1002/Elps.200600707  0.357
2007 Cebrian-Losantos B, Krokhin AA, Stepanenko IN, Eichinger R, Jakupec MA, Arion VB, Keppler BK. Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties. Inorganic Chemistry. 46: 5023-5033. PMID 17497853 DOI: 10.1021/Ic700405Y  0.425
2007 Scaffidi-Domianello YY, Nazarov AA, Haukka M, Galanski M, Keppler BK, Schneider J, Du P, Eisenberg R, Kukushkin VY. First example of the solid-state thermal cyclometalation of ligated benzophenone imine giving novel luminescent platinum(II) species. Inorganic Chemistry. 46: 4469-82. PMID 17451237 DOI: 10.1021/Ic062414K  0.396
2007 Heffeter P, Jakupec MA, Körner W, Chiba P, Pirker C, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK, Berger W. Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24). Biochemical Pharmacology. 73: 1873-1886. PMID 17445775 DOI: 10.1016/J.Bcp.2007.03.002  0.315
2007 Schmid WF, Zorbas-Seifried S, John RO, Arion VB, Jakupec MA, Roller A, Galanski M, Chiorescu I, Zorbas H, Keppler BK. The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro. Inorganic Chemistry. 46: 3645-56. PMID 17402728 DOI: 10.1021/Ic070098J  0.309
2007 Groessl M, Reisner E, Hartinger CG, Eichinger R, Semenova O, Timerbaev AR, Jakupec MA, Arion VB, Keppler BK. Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity. Journal of Medicinal Chemistry. 50: 2185-93. PMID 17402720 DOI: 10.1021/Jm061081Y  0.641
2007 Timerbaev AR, Vasylenko OO, Foteeva LS, Rudnev AV, Semenova O, Keppler BK. Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance. Ieee Journal of Solid-State Circuits. 30: 399-406. PMID 17396599 DOI: 10.1002/Jssc.200600305  0.392
2007 Berger I, Nazarov AA, Hartinger CG, Groessl M, Valiahdi S, Jakupec MA, Keppler BK. A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin? Chemmedchem. 2: 505-514. PMID 17340670 DOI: 10.1002/Cmdc.200600279  0.462
2007 Kowol CR, Berger R, Eichinger R, Roller A, Jakupec MA, Schmidt PP, Arion VB, Keppler BK. Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide Reductase Journal of Medicinal Chemistry. 50: 1254-1265. PMID 17315858 DOI: 10.1021/Jm0612618  0.367
2007 Galanski M, Keppler BK. Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue. Anti-Cancer Agents in Medicinal Chemistry. 7: 55-73. PMID 17266505 DOI: 10.2174/187152007779314017  0.347
2007 Aleksenko SS, Hartinger CG, Semenova O, Meelich K, Timerbaev AR, Keppler BK. Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis. Journal of Chromatography A. 1155: 218-221. PMID 17240384 DOI: 10.1016/J.Chroma.2007.01.017  0.415
2007 Zorbas-Seifried S, Jakupec MA, Kukushkin NV, Groessl M, Hartinger CG, Semenova O, Zorbas H, Kukushkin VY, Keppler BK. Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands. Molecular Pharmacology. 71: 357-65. PMID 17050805 DOI: 10.1124/Mol.106.030726  0.416
2007 Hartinger CG, Ang WH, Casini A, Messori L, Keppler BK, Dyson PJ. Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI Journal of Analytical Atomic Spectrometry. 22: 960-967. DOI: 10.1039/B703350H  0.345
2007 Schmid WF, John RO, Arion VB, Jakupec MA, Keppler BK. Highly Antiproliferative Ruthenium(II) and Osmium(II) Arene Complexes with Paullone-Derived Ligands Organometallics. 26: 6643-6652. DOI: 10.1021/Om700813C  0.452
2007 Budzisz E, Malecka M, Keppler BK, Arion VB, Andrijewski G, Krajewska U, Rozalski M. Synthesis, Structure, Protolytic Properties, Alkylating and Cytotoxic Activity of Novel Platinum(II) and Palladium(II) Complexes with Pyrazole-Derived Ligands European Journal of Inorganic Chemistry. 2007: 3728-3735. DOI: 10.1002/Ejic.200700139  0.455
2007 Grguric-Sipka S, Kowol CR, Valiahdi S, Eichinger R, Jakupec MA, Roller A, Shova S, Arion VB, Keppler BK. Ruthenium(II) Complexes of Thiosemicarbazones: The First Water-Soluble Complex with pH-Dependent Antiproliferative Activity European Journal of Inorganic Chemistry. 2007: 2870-2878. DOI: 10.1002/Ejic.200601196  0.422
2007 Stepanenko IN, Cebrián‐Losantos B, Arion VB, Krokhin AA, Nazarov AA, Keppler BK. The Complexes [OsCl2(azole)2(dmso)2] and [OsCl2(azole)(dmso)3]: Synthesis, Structure, Spectroscopic Properties and Catalytic Hydration of Chloronitriles European Journal of Inorganic Chemistry. 2007: 400-411. DOI: 10.1002/Ejic.200600859  0.428
2007 Berger I, Nazarov AA, Hartinger CG, Groessl M, Valiahdi S, Jakupec MA, Keppler BK. Cover Picture: A glucose derivative as natural alternative to the cyclohexane‐1,2‐diamine ligand in the anticancer drug oxaliplatin? (ChemMedChem 4/2007) Chemmedchem. 2: 385-385. DOI: 10.1002/Cmdc.200790008  0.303
2006 Zorbas-Seifried S, Hartinger CG, Meelich K, Galanski M, Keppler BK, Zorbas H. DNA interactions of pH-sensitive, antitumor bis(aminoalcohol) dichloroplatinum(II) complexes Biochemistry. 45: 14817-14825. PMID 17144675 DOI: 10.1021/Bi061063I  0.353
2006 Rudnev AV, Foteeva LS, Kowol C, Berger R, Jakupec MA, Arion VB, Timerbaev AR, Keppler BK. Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins. Journal of Inorganic Biochemistry. 100: 1819-1826. PMID 16938349 DOI: 10.1016/J.Jinorgbio.2006.07.003  0.44
2006 Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK. From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A) Journal of Inorganic Biochemistry. 100: 891-904. PMID 16603249 DOI: 10.1016/J.Jinorgbio.2006.02.013  0.351
2006 Schluga P, Hartinger CG, Egger A, Reisner E, Galanski M, Jakupec MA, Keppler BK. Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP. Dalton Transactions (Cambridge, England : 2003). 1796-802. PMID 16568190 DOI: 10.1039/B511792E  0.606
2006 Dobrov A, Arion VB, Kandler N, Ginzinger W, Jakupec MA, Rufinska A, Keyserlingk NGV, Galanski M, Kowol C, Keppler BK. The first metal-based paullone derivative with high antiproliferative activity in vitro. Inorganic Chemistry. 45: 1945-1950. PMID 16499355 DOI: 10.1021/Ic0511120  0.393
2006 Polec‐Pawlak K, Abramski JK, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK, Jarosz M. Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins. Electrophoresis. 27: 1128-1135. PMID 16440400 DOI: 10.1002/Elps.200500694  0.347
2006 Heffeter P, Jakupec MA, Körner W, Wild S, Keyserlingk NGv, Elbling L, Zorbas H, Korynevska A, Knasmüller S, Sutterlüty H, Micksche M, Keppler BK, Berger W. Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24). Biochemical Pharmacology. 71: 426-440. PMID 16343446 DOI: 10.1016/J.Bcp.2005.11.009  0.367
2006 Huang Z, Timerbaev AR, Keppler BK, Hirokawa T. Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques. Journal of Chromatography. A. 1106: 75-9. PMID 16203005 DOI: 10.1016/J.Chroma.2005.09.042  0.316
2006 Reisner E, Arion VB, Eichinger A, Kandler N, Giester G, Pombeiro AJ, Keppler BK. Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes. Inorganic Chemistry. 44: 6704-16. PMID 16156629 DOI: 10.1021/Ic0503737  0.626
2006 Heffeter P, Jakupec MA, Körner W, Chiba P, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK, Berger W. 180 POSTER Enhanced anticancer activity of [Tris(1,10-phenanthroline)-lanthanum(III)]-trithiocyanate (KP772; FFC24) against ABC-transporter-overexpressing cells Ejc Supplements. 4: 57. DOI: 10.1016/S1359-6349(06)70185-9  0.305
2006 Hartinger CG, Ferri-Mendoza MG, Nazarov AA, Keppler BK. Electrospray ionization mass spectrometric study on the coordination behavior of dacarbazine towards transition metal ions Polyhedron. 25: 1971-1978. DOI: 10.1016/J.Poly.2005.12.022  0.442
2006 Rothenburger C, Galanski M, Arion VB, Görls H, Weigand W, Keppler BK. Synthesis and Characterization of [(1R,2R)-trans-Diaminocyclohexane]platinum(II) Coordinated to Sulfur and Selenium Amino Acids European Journal of Inorganic Chemistry. 2006: 3746-3752. DOI: 10.1002/Ejic.200600453  0.329
2006 Meelich K, Galanski M, Arion VB, Keppler BK. Bis(2-amino alcohol-κN)dicarboxylatoplatinum(II) Complexes – Elegant Synthesis via Ring-Opening of Bis(2-amino alcoholato-κ2N,O)platinum(II) Species with Dicarboxylic Acids European Journal of Inorganic Chemistry. 2006: 2476-2483. DOI: 10.1002/Ejic.200600193  0.402
2006 Reithofer M, Galanski M, Roller A, Keppler BK. An Entry to Novel Platinum Complexes: Carboxylation of Dihydroxoplatinum(IV) Complexes with Succinic Anhydride and Subsequent Derivatization European Journal of Inorganic Chemistry. 2006: 2612-2617. DOI: 10.1002/Ejic.200600108  0.418
2005 Galanski M, Slaby S, Jakupec MA, Keppler BK. Synthesis and in vitro Antitumor Potency of(Cyclohexane-1,2-Diamine)Platinum(II) Complexeswith Aminotris(Methylenephosphonic Acid) as Bone-Seeking Ligand Bioinorganic Chemistry and Applications. 3: 179-190. PMID 18365098 DOI: 10.1155/Bca.2005.179  0.43
2005 Schluga P, Hartinger CG, Galanski M, Meelich K, Timerbaev AR, Keppler BK. Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands : biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry Analyst. 130: 1383-1389. PMID 16172663 DOI: 10.1039/B506490B  0.407
2005 Galanski M, Jakupec MA, Keppler BK. Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches. Current Medicinal Chemistry. 12: 2075-2094. PMID 16101495 DOI: 10.2174/0929867054637626  0.389
2005 Habala L, Galanski M, Yasemi A, Nazarov AA, Keyserlingk NGv, Keppler BK. Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives European Journal of Medicinal Chemistry. 40: 1149-1155. PMID 16040163 DOI: 10.1016/J.Ejmech.2005.06.003  0.392
2005 Kapitza S, Jakupec MA, Uhl M, Keppler BK, Marian B. The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells Cancer Letters. 226: 115-121. PMID 16039951 DOI: 10.1016/J.Canlet.2005.01.002  0.302
2005 Reisner E, Arion VB, Rufi?ska A, Chiorescu I, Schmid WF, Keppler BK. Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole. Dalton Transactions (Cambridge, England : 2003). 2355-64. PMID 15995743 DOI: 10.1039/B503650J  0.614
2005 Timerbaev AR, Rudnev AV, Semenova O, Hartinger CG, Keppler BK. Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis. Analytical Biochemistry. 341: 326-333. PMID 15907879 DOI: 10.1016/J.Ab.2005.03.020  0.378
2005 Jakupec MA, Reisner E, Eichinger A, Pongratz M, Arion VB, Galanski M, Hartinger CG, Keppler BK. Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential. Journal of Medicinal Chemistry. 48: 2831-7. PMID 15828821 DOI: 10.1021/Jm0490742  0.63
2005 Rudnev AV, Aleksenko SS, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK. Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel‐Dreyer method Ieee Journal of Solid-State Circuits. 28: 121-127. PMID 15754818 DOI: 10.1002/Jssc.200401930  0.312
2005 Rappel C, Galanski M, Yasemi A, Habala L, Keppler BK. Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients. Electrophoresis. 26: 878-884. PMID 15714548 DOI: 10.1002/Elps.200410053  0.337
2005 Egger A, Arion VB, Reisner E, Cebrián-Losantos B, Shova S, Trettenhahn G, Keppler BK. Reactions of potent antitumor complex trans-[Ru(III)Cl4(indazole)2]- with a DNA-relevant nucleobase and thioethers: insight into biological action. Inorganic Chemistry. 44: 122-32. PMID 15627368 DOI: 10.1021/Ic048967H  0.617
2005 Kapitza S, Pongratz M, Jakupec MA, Heffeter P, Berger W, Lackinger L, Keppler BK, Marian B. Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells Journal of Cancer Research and Clinical Oncology. 131: 101-110. PMID 15503135 DOI: 10.1007/S00432-004-0617-0  0.378
2005 Heffeter P, Pongratz M, Steiner E, Chiba P, Jakupec MA, Elbling L, Marian B, Körner W, Sevelda F, Micksche M, Keppler BK, Berger W. Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A). Journal of Pharmacology and Experimental Therapeutics. 312: 281-289. PMID 15331656 DOI: 10.1124/Jpet.104.073395  0.301
2005 Dittrich C, Hochhaus A, Schaad S, Salama C, Jaehde U, Jakupec MA, Hauses M, Gneist M, Keppler BK. Phase I and pharmacokinetic study of the oral tris-(8-quinolinolato)gallium(III) complex (FFC11, KP46) in patients with solid tumors - a study of the CESAR Central European Society for Anticancer Drug Research - EWIV Journal of Clinical Oncology. 23: 3205-3205. DOI: 10.1200/Jco.2005.23.16_Suppl.3205  0.303
2005 Sulyok M, Hann S, Hartinger CG, Keppler BK, Stingeder G, Koellensperger G. Two dimensional separation schemes for investigation of the interaction of an anticancer ruthenium(III) compound with plasma proteins Journal of Analytical Atomic Spectrometry. 20: 856-863. DOI: 10.1039/B508060F  0.327
2005 Nazarov AA, Koroteev MP, Hartinger CG, Keppler BK, Nifant'ev EE. Bis- and tris-bicyclophosphites of d-glucofuranoside. Unexpected catalysis of P(III/V)-oxidation by triethylamine Tetrahedron. 61: 10943-10950. DOI: 10.1016/J.Tet.2005.08.102  0.305
2005 Galanski M, Yasemi A, Jakupec MA, Keyserlingk NGv, Keppler BK. Synthesis, Cytotoxicity, and Structure-Activity Relationships of New Oxaliplatin Derivatives Monatshefte Fur Chemie. 136: 693-700. DOI: 10.1007/S00706-004-0241-3  0.398
2005 Nazarov AA, Koroteev MP, Hartinger CG, Keppler BK, Nifant’ev EE. On the Coordination Properties of New Bicyclophosphite-Carbohydrates Monatshefte Fur Chemie. 136: 137-146. DOI: 10.1007/S00706-004-0238-Y  0.361
2005 Hartinger CG, Nazarov AA, Arion VB, Giester G, Kuznetsov ML, Galanski M, Keppler BK. 1,1'‐Bis(oxazolin‐2‐yl)ferrocenes: An Investigation of Their Complexation Behavior toward [Pd(η3‐allyl)Cl]2 European Journal of Inorganic Chemistry. 2005: 1589-1600. DOI: 10.1002/Ejic.200400737  0.344
2004 Kynast B, Graf V Keyserlingk N, Hauses M, Heffeter P, Jakupec M, Unfried P, Berger W, Keppler BK. Novel tumor-inhibiting metal complexes: Preclinical efficacy and toxicity of the lanthanum(III) complex [tris(1,10-phenantroline)lanthanum]trithiocyanate FFC24. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3166. PMID 28014953 DOI: 10.1200/Jco.2004.22.14_Suppl.3166  0.438
2004 Jakupec MA, Keppler BK. Gallium in cancer treatment. Current Topics in Medicinal Chemistry. 4: 1575-1583. PMID 15579097 DOI: 10.2174/1568026043387449  0.366
2004 Warnke U, Rappel C, Meier H, Kloft C, Galanski M, Hartinger CG, Keppler BK, Jaehde U. Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation. Chembiochem : a European Journal of Chemical Biology. 5: 1543-9. PMID 15515088 DOI: 10.1002/Cbic.200400015  0.312
2004 Reisner E, Arion VB, Guedes da Silva MF, Lichtenecker R, Eichinger A, Keppler BK, Kukushkin VY, Pombeiro AJ. Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole. Inorganic Chemistry. 43: 7083-93. PMID 15500346 DOI: 10.1021/Ic049479C  0.607
2004 Galanski M, Yasemi A, Slaby S, Jakupec MA, Arion VB, Rausch M, Nazarov AA, Keppler BK. Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible. European Journal of Medicinal Chemistry. 39: 707-714. PMID 15276304 DOI: 10.1016/J.Ejmech.2004.04.003  0.356
2004 Timerbaev AR, Aleksenko SS, Polec-Pawlak K, Ruzik R, Semenova O, Hartinger CG, Oszwaldowski S, Galanski M, Jarosz M, Keppler BK. Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin. Electrophoresis. 25: 1988-1995. PMID 15237398 DOI: 10.1002/Elps.200305984  0.385
2004 Pongratz M, Schluga P, Jakupec MA, Arion VB, Hartinger CG, Allmaier G, Keppler BK. Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy Journal of Analytical Atomic Spectrometry. 19: 46-51. DOI: 10.1039/B309160K  0.36
2004 Heffeter P, Jakupec MA, Micksche M, Hauses M, Keyserlingk NGv, Keppler BK, Berger W. 424 In vivo and in vitro anticancer activity of the lanthanum compound KP772 (FFC24) Ejc Supplements. 2: 127. DOI: 10.1016/S1359-6349(04)80432-4  0.319
2004 Galanski M, Baumgartner C, Meelich K, Arion VB, Fremuth M, Jakupec MA, Schluga P, Hartinger CG, Keyserlingk NGv, Keppler BK. Synthesis, crystal structure and pH dependent cytotoxicity of (SP-4-2)-bis(2-aminoethanolato-κ2N, O)platinum(II): a representative of novel pH sensitive anticancer platinum complexes Inorganica Chimica Acta. 357: 3237-3244. DOI: 10.1016/J.Ica.2004.04.003  0.314
2004 Budzisz E, Keppler BK, Giester G, Wozniczka M, Kufelnicki A, Nawrot B. Synthesis, Crystal Structure and Biological Characterization of a Novel Palladium(II) Complex with a Coumarin‐Derived Ligand European Journal of Inorganic Chemistry. 2004: 4412-4419. DOI: 10.1002/Ejic.200400483  0.424
2003 Galanski M, Slaby S, Jakupec MA, Keppler BK. Synthesis, Characterization, and in Vitro Antitumor Activity of Osteotropic Diam(m)ineplatinum(II) Complexes Bearing a N,N-Bis(phosphonomethyl)glycine Ligand† Journal of Medicinal Chemistry. 46: 4946-4951. PMID 14584945 DOI: 10.1021/Jm0308040  0.429
2003 Galanski M, Arion VB, Jakupec MA, Keppler BK. Recent Developments in the Field of Tumor-Inhibiting Metal Complexes Current Pharmaceutical Design. 9: 2078-2089. PMID 14529417 DOI: 10.2174/1381612033454180  0.4
2003 Arion VB, Reisner E, Fremuth M, Jakupec MA, Keppler BK, Kukushkin VY, Pombeiro AJ. Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes. Inorganic Chemistry. 42: 6024-31. PMID 12971773 DOI: 10.1021/Ic034605I  0.601
2003 Hartinger CG, Schluga P, Galanski M, Baumgartner C, Timerbaev AR, Keppler BK. Tumor‐inhibiting platinum(II) complexes with aminoalcohol ligands: Comparison of the mode of action by capillary electrophoresis and electrospray ionization‐mass spectrometry Electrophoresis. 24: 2038-2044. PMID 12858373 DOI: 10.1002/Elps.200305463  0.388
2003 Hartinger CG, Timerbaev AR, Keppler BK. Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges. Electrophoresis. 24: 2023-2037. PMID 12858372 DOI: 10.1002/Elps.200305452  0.323
2003 Jakupec MA, Galanski M, Keppler BK. Tumour-inhibiting platinum complexes--state of the art and future perspectives. Reviews of Physiology Biochemistry and Pharmacology. 146: 1-53. PMID 12605304 DOI: 10.1007/S10254-002-0001-X  0.326
2003 Hartinger CG, Nazarov AA, Chevchenko V, Arion VB, Galanski M, Keppler BK. Synthesis, crystal structures, and electrospray ionisation mass spectrometry investigations of ether- and thioether-substituted ferrocenes Dalton Transactions. 3098-3102. DOI: 10.1039/B304115H  0.343
2003 Unfried P, Reisner E, Fremuth M, Jakupec MA, Lichtenecker R, Arion VB, Keppler BK. Two novel trans-tetrachloro(dimethyl sulfoxide)azoleruthenate(III) complexes, their antiproliferative activity and the coordination mode of triazole in H2trz[RuCl4(dmso)(Htrz)] Journal of Inorganic Biochemistry. 96: 243. DOI: 10.1016/S0162-0134(03)80793-6  0.594
2003 Arion VB, Reisner E, Fremuth M, Jakupec MA, Keppler BK, Kukushkin VY, Pombeiro AJ. Synthesis, structure, spectroscopic and in vitro anti-tumor properties of triazolium salts of cis- and trans-tetrachlorobis(triazole)ruthenate(III) Journal of Inorganic Biochemistry. 96: 95. DOI: 10.1016/S0162-0134(03)80556-1  0.546
2003 Arion VB, Galanski M, Zimmermann W, Berger M, Baumgartner C, Keppler BK. Carboxylation of 2-hydroxyethyl substituted tetrachloro(ethane-1,2-diamine)platinum(IV) complexes. A new synthetic approach to anticancer platinum compounds Journal of Inorganic Biochemistry. 96: 94. DOI: 10.1016/S0162-0134(03)80555-X  0.408
2003 Arion VB, Galanski M, Baumgartner C, Meelich K, Fremuth M, Jakupec MA, Keppler BK. Bis(aminoalcohol)dichloroplatinum(II) complexes and their mono and double ring-closed alcoholato species. Novel prodrugs for platinum based antitumor chemotherapy Journal of Inorganic Biochemistry. 96: 93. DOI: 10.1016/S0162-0134(03)80554-8  0.375
2003 Galanski M, Baumgartner C, Arion V, Keppler BK. Bis(2-aminobutanol)dichloroplatinum(II) Complexes and Their Singly and Doubly Ring-Closed Butanolato Species − Novel Prodrugs for Platinum-Based Antitumour Chemotherapy? European Journal of Inorganic Chemistry. 2003: 2619-2625. DOI: 10.1002/Ejic.200300050  0.409
2002 Arion VB, Jakupec MA, Galanski M, Unfried P, Keppler BK. Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine 4N-dimethylthiosemicarbazone Journal of Inorganic Biochemistry. 91: 298-305. PMID 12121788 DOI: 10.1016/S0162-0134(02)00419-1  0.435
2002 Timerbaev AR, Küng A, Keppler BK. Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies. Journal of Chromatography A. 945: 25-44. PMID 11860140 DOI: 10.1016/S0021-9673(01)01489-3  0.325
2002 Makarycheva-Mikhailova AV, Haukka M, Bokach NA, Garnovskii DA, Galanski M, Keppler BK, Pombeiro AJL, Kukushkin VY. Platinum(IV)-mediated coupling of dione monoximes and nitriles: a novel reactivity pattern of the classic oxime-based chelating ligands New Journal of Chemistry. 26: 1085-1091. DOI: 10.1039/B202947B  0.367
2002 Nazarov AA, Hartinger CG, Arion VB, Giester G, Keppler BK. Synthesis of ferrocenylglucose phosphonite and bisphosphinite: Pd(II) and Pt(II) complexes, Pd-catalyzed allylic alkylation Tetrahedron. 58: 8489-8492. DOI: 10.1016/S0040-4020(02)01027-X  0.338
2002 Küng A, Galanski M, Baumgartner C, Keppler BK. Reaction of (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) with 5′-GMP under simulated physiological conditions, a CZE-ESI-MS study Inorganica Chimica Acta. 339: 9-13. DOI: 10.1016/S0020-1693(02)00915-5  0.4
2002 Galanski M, Zimmermann W, Berger M, Baumgartner C, Giester G, Keppler BK. Carboxylation of 2-Hydroxyethyl-Substituted Tetrachloro(ethane-1,2-diamine)platinum(IV) Complexes — A New Synthetic Approach to Anticancer Platinum Compounds European Journal of Inorganic Chemistry. 2002: 417-421. DOI: 10.1002/1099-0682(20022)2002:2<417::Aid-Ejic417>3.0.Co;2-4  0.447
2001 Küng A, Strickmann DB, Galanski M, Keppler BK. Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry. Journal of Inorganic Biochemistry. 86: 691-698. PMID 11583787 DOI: 10.1016/S0162-0134(01)00225-2  0.369
2001 Küng A, Pieper T, Keppler BK. Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis Journal of Chromatography B: Biomedical Sciences and Applications. 759: 81-89. PMID 11499632 DOI: 10.1016/S0378-4347(01)00205-5  0.408
2001 Hann S, Zenker A, Galanski M, Bereuter T, Stingeder G, Keppler BK. HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate. Fresenius Journal of Analytical Chemistry. 370: 581-586. PMID 11496990 DOI: 10.1007/S002160100740  0.331
2001 Zöllner P, Zenker A, Galanski M, Keppler BK, Lindner W. Reaction monitoring of platinum(II) complex--5'-guanosine monophosphate adduct formation by ion exchange liquid chromatography/electrospray ionization mass spectrometry. Journal of Mass Spectrometry : Jms. 36: 742-53. PMID 11473397 DOI: 10.1002/Jms.178  0.419
2001 Malina J, Novakova O, Keppler BK, Alessio E, Brabec V. Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 6: 435-45. PMID 11372202 DOI: 10.1007/S007750100223  0.339
2001 Küng A, Pieper T, Wissiack R, Rosenberg E, Keppler BK. Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS Journal of Biological Inorganic Chemistry. 6: 292-299. PMID 11315565 DOI: 10.1007/S007750000203  0.407
2001 Küng A, Zenker A, Galanski M, Keppler BK. Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides Journal of Inorganic Biochemistry. 83: 181-186. PMID 11237257 DOI: 10.1016/S0162-0134(00)00182-3  0.403
2001 Pieper T, Sommer M, Galanski M, Keppler BK, Giester G. [RuCl3ind3] and [RuCl2ind4]: Two New Ruthenium Complexes derived from the Tumor-inhibiting RuIII Compound HInd (OC-6-11)-[RuCl4ind2] (ind = indazole) Zeitschrift FüR Anorganische Und Allgemeine Chemie. 627: 261-265. DOI: 10.1002/1521-3749(200102)627:2<261::Aid-Zaac261>3.0.Co;2-K  0.378
2001 Galanski M, Zimmermann W, Baumgartner C, Keppler BK. The Intramolecular Ligand-Exchange Reaction of (SP-4-2)-Dichlorobis(2-hydroxyethylamine)platinum(II) and (OC-6-22)-Tetrachlorobis(2-hydroxyethylamine)platinum(IV), a1H and15N,1H-HMQC NMR Study European Journal of Inorganic Chemistry. 2001: 1145-1149. DOI: 10.1002/1099-0682(200105)2001:5<1145::Aid-Ejic1145>3.0.Co;2-E  0.4
2000 Galanski M, Berger M, Keppler BK. Synthesis of (N,N'-Bis(2-Hydroxyethyl)Ethane-1,2-Diamine)Malonatoplatinum(II) and X-Ray Crystal Structure of the Cis-R,S-Isomer. Metal-Based Drugs. 7: 349-355. PMID 18475967 DOI: 10.1155/Mbd.2000.349  0.394
2000 Messori L, Vilchez FG, Vilaplana R, Piccioli F, Alessio E, Keppler BK. Binding of Antitumor Ruthenium(III) Complexes to Plasma Proteins. Metal-Based Drugs. 7: 335-342. PMID 18475965 DOI: 10.1155/Mbd.2000.335  0.378
2000 Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis. Journal of Chromatography B: Biomedical Sciences and Applications. 745: 211-219. PMID 10997716 DOI: 10.1016/S0378-4347(00)00096-7  0.314
2000 Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Time-dependent interactions of platinum(II) complexes with 5'-GMP under simulated physiological conditions studies by capillary electrophoresis. Journal of Biological Inorganic Chemistry. 5: 498-504. PMID 10968621 DOI: 10.1007/S007750050010  0.409
2000 Galanski M, Keppler BK. Is reduction required for antitumour activity of platinum(IV) compounds? Characterisation of a platinum(IV)–nucleotide adduct [enPt(OCOCH3)3(5′-GMP)] by NMR spectroscopy and ESI-MS Inorganica Chimica Acta. 300: 783-789. DOI: 10.1016/S0020-1693(99)00613-1  0.452
1999 Trynda-Lemiesz L, Kozłowski H, Keppler BK. Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin. Journal of Inorganic Biochemistry. 77: 141-146. PMID 10643655 DOI: 10.1016/S0162-0134(99)00183-X  0.398
1999 Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides Journal of Chromatography A. 852: 337-346. PMID 10480259 DOI: 10.1016/S0021-9673(99)00467-7  0.347
1999 Trynda-Lemiesz L, Keppler BK, KozłLowski H. Studies on the interactions between human serum albumin and imidazolium [trans-tetrachlorobis(imidazol)ruthenate(III)]. Journal of Inorganic Biochemistry. 73: 123-128. PMID 10331241 DOI: 10.1016/S0162-0134(99)00004-5  0.304
1999 Zimmermann W, Galanski M, Keppler BK, Giester G. Synthesis and structures of ( SP -4-2)-diiodobis(2-hydroxyethylamine)platinum(II), ( SP -4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) and ( OC -6-22)-bis(2-hydroxyethylamine)tetrachloroplatinum(IV) in the crystal Inorganica Chimica Acta. 292: 127-130. DOI: 10.1016/S0020-1693(99)00175-9  0.376
1999 Szpunar J, Makarov A, Pieper T, Keppler BK, Łobiński R. Investigation of metallodrug–protein interactions by size-exclusion chromatography coupled with inductively coupled plasma mass spectrometry (ICP-MS) Analytica Chimica Acta. 387: 135-144. DOI: 10.1016/S0003-2670(99)00074-4  0.331
1999 Peti W, Pieper T, Sommer M, Keppler BK, Giester G. Synthesis of Tumor‐Inhibiting Complex Salts Containing the Anion trans‐Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt European Journal of Inorganic Chemistry. 1999: 1551-1555. DOI: 10.1002/(Sici)1099-0682(199909)1999:9<1551::Aid-Ejic1551>3.0.Co;2-7  0.388
1998 Kersten L, Bräunlich H, Keppler BK, Gliesing C, Wendelin M, Westphal J. Comparative nephrotoxicity of some antitumour-active platinum and ruthenium complexes in rats. Journal of Applied Toxicology. 18: 93-101. PMID 9570691 DOI: 10.1002/(Sici)1099-1263(199803/04)18:2<93::Aid-Jat472>3.0.Co;2-W  0.36
1998 Pieper T, Keppler BK. Tumor-inhibiting ruthenium complexes -formulation and analytical characterization Analusis. 26: 84-90. DOI: 10.1051/Analusis:199826060084  0.346
1998 Hartmann M, Lipponer K, Keppler BK. Imidazole release from the antitumor-active ruthenium complex imidazolium trans-tetrachlorobis(imidazole) ruthenate(III) by biologically occurring nucleophiles Inorganica Chimica Acta. 267: 137-141. DOI: 10.1016/S0020-1693(97)05556-4  0.42
1997 Depenbrock H, Schmelcher S, Peter R, Keppler BK, Weirich G, Block T, Rastetter J, Hanauske A-. Preclinical Activity of Trans-indazolium (Tetrachlorobisindazoleruthenate(III)) (NSC 666158; IndCR; KP 1019) Against Tumour Colony-forming Units and Haematopoietic Progenitor Cells European Journal of Cancer. 33: 2404-2410. PMID 9616290 DOI: 10.1016/S0959-8049(97)00277-3  0.34
1997 Galanski M, Keppler BK. Carboxylation of dihydroxoplatinum(IV) complexes with acyl chlorides. Crystal structures of the trans-R,R- and trans-S,S-isomer of (OC-6-33)-bis(1-adamantanecarboxylato)-(cyclohexane-1,2-diamine)dichloroplatinum(IV) Inorganica Chimica Acta. 265: 271-274. DOI: 10.1016/S0020-1693(97)05639-9  0.372
1997 Einhäuser T, Galanski M, Vogel E, Keppler B. The influence of calcium ions on the DNA binding behaviour of a new platinum(II) compound linked to an amino phosphonic acid Inorganica Chimica Acta. 257: 265-268. DOI: 10.1016/S0020-1693(96)05477-1  0.335
1997 Dittes U, Vogel E, Keppler BK. Overview on bismuth(III) and bismuth(V) complexes with activity against Helicobacter pylori Coordination Chemistry Reviews. 163: 345-364. DOI: 10.1016/S0010-8545(97)00042-8  0.379
1997 Hartmann M, Robert A, Duarte V, Keppler BK, Meunier B. Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents Journal of Biological Inorganic Chemistry. 2: 427-432. DOI: 10.1007/S007750050153  0.415
1996 Lipponer K, Vogel E, Keppler BK. Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliumtetrachlorobis-(1-Methylindazole)Ruthenate(III) and its Hydrolysis Product trans-Monoaquatrichlorobis-(1-Methylindazole)-Ruthenate(III). Metal-Based Drugs. 3: 243-260. PMID 18472901 DOI: 10.1155/Mbd.1996.243  0.418
1996 Kratz F, Keppler BK, Hartmann M, Messori L, Berger MR. Comparison of the Antiproliferative Activity of Two Antitumour Ruthenium(III) Complexes With Their Apotransferrin and Transferrin-Bound Forms in a Human Colon Cancer Cell Line. Metal-Based Drugs. 3: 15-23. PMID 18472789 DOI: 10.1155/Mbd.1996.15  0.414
1996 Galanski M, Keppler BK. Carboxylation of Dihydroxoplatinum(IV) Complexes via a New Synthetic Pathway. Inorganic Chemistry. 35: 1709-1711. PMID 11666395 DOI: 10.1021/Ic9509490  0.381
1996 Winckler W, Pieper T, Keppler BK. Preparation Of Octaethyl-3-Amino-Pentane-1,1,5,5-Tetrakisphosphonate By Catalytic Hydrogenation Of The Corresponding 3-Nitro-Compound Phosphorus Sulfur and Silicon and the Related Elements. 112: 137-141. DOI: 10.1080/10426509608046357  0.316
1996 Einhäuser TJ, Galanski M, Keppler BK. Determination of platinum in protein-bound CDDP and DBP by inductively coupled plasma optical emission spectrometry and electrothermal atomic absorption spectrometry Journal of Analytical Atomic Spectrometry. 11: 747-750. DOI: 10.1039/Ja9961100747  0.31
1996 Hartmann M, Einhäuser TJ, Keppler BK. Two antitumour ruthenium(III) complexes showing selectivity in their binding towards poly(dG)·poly(dC) and poly(dA)·poly(dT) Chemical Communications. 1741-1742. DOI: 10.1039/Cc9960001741  0.342
1996 Dittes U, Keppler BK, Nuber B. Synthesis and Structure of Seven‐Coordinate Bismuth(V) Complexes with Benzenoid and Non‐Benzenoid Arene Ligands: Tri(aryl)tropolonatobismuth(V) Complexes Angewandte Chemie. 35: 67-68. DOI: 10.1002/Anie.199600671  0.37
1995 Diemer R, Dittes U, Nuber B, Seifried V, Opferkuch W, Keppler BK. Synthesis, Characterization and Molecular Structures of some Bismuth(III) Complexes with Thiosemicarbazones and Dithiocarbazonic Acid Methylester Derivatives with Activity against Helicobacter Pylori. Metal-Based Drugs. 2: 271-292. PMID 18472778 DOI: 10.1155/Mbd.1995.271  0.343
1995 Galanski M, Keppler BK. Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands. Metal-Based Drugs. 2: 57-63. PMID 18472746 DOI: 10.1155/Mbd.1995.57  0.441
1995 Leperre A, Millart H, Prévost A, Trenque T, Kantelip J, Keppler B. Compared effects of ruthenium red and cis [Ru(NH3)4Cl2]Cl on the isolated ischaemic-reperfused rat heart Fundamental & Clinical Pharmacology. 9: 545-553. PMID 8808175 DOI: 10.1111/J.1472-8206.1995.Tb00532.X  0.312
1995 Hartmann M, Keppler BK. Inorganic Anticancer Agents: Their Chemistry and Antitumor Properties Comments On Inorganic Chemistry. 16: 339-372. DOI: 10.1080/02603599508035776  0.415
1995 Gund A, Keppler BK, Nuber B. Five-Coordinate Platinum Olefin Complexes: Synthesis, 1H NMR Investigations, and Crystal Structure of a Platinum .eta.2-Ethylene Crown Ether Complex Inorganic Chemistry. 34: 2788-2790. DOI: 10.1021/Ic00114A043  0.386
1995 Roulette V, Depenbrock H, Peter R, Keppler BK, Block T, Fellbaum C, Schweighart S, Rastetter J, Hanauske A-. 118 Effects of KP 1220, a new platinum compound, on colony forming units from freshly explanted human tumors in vitro European Journal of Cancer. 31. DOI: 10.1016/0959-8049(95)95373-E  0.314
1995 Bauer RP, Depenbrock H, Peter R, Keppler BK, Fellbaum CH, Block T, Rastetter J, Hanauske A-. 117 Effects of KP 735, a new platinum-based antitumor agent on clonogenic growth of freshly explanted human tumors in vitro European Journal of Cancer. 31. DOI: 10.1016/0959-8049(95)95372-D  0.323
1995 Dittes U, Diemer R, Lenz O, Keppler BK. New bismuth(III) complexes with derivatives of tropolones and thiosemicarbazones against the gastritis-causing bacteria helicobacter pylori Journal of Inorganic Biochemistry. 59: 215. DOI: 10.1016/0162-0134(95)97321-G  0.349
1995 Galanski M, Keppler BK, Klenner T. Antitumor platinum compounds linked to amino phosphonic acids: Drug targeting with osteotropic platinum compounds against bone malignancies Journal of Inorganic Biochemistry. 59: 212. DOI: 10.1016/0162-0134(95)97318-K  0.306
1995 Marx MBL, Pritzkow H, Keppler BK. Synthesis and characterization of 9,10-diethyl-2,4,6,8-tetraoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane (I) and S-9,10-dimethyl-2,4,6,8-tetraoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane (II), two compounds analogous to As(III)oxide Journal of Inorganic Biochemistry. 59: 210. DOI: 10.1016/0162-0134(95)97316-I  0.34
1995 Chatlas J, Eldik Rv, Keppler BK. Spontaneous aquation reactions of a promising tumor inhibitor trans-imidazolium-tetrachlorobis(imidazole)ruthenium(III), trans-HIm[RuCl4(Im)2] Inorganica Chimica Acta. 233: 59-63. DOI: 10.1016/0020-1693(94)04447-4  0.315
1995 Galanski M, Keppler BK. Synthesis and characterization of new diam(M)ine platinum(IV) complexes containing lipophilic carboxylate ligands Journal of Cancer Research and Clinical Oncology. 121. DOI: 10.1007/Bf02572163  0.452
1995 Dittes U, Diemer R, Keppler BK. New tumor-inhibiting bismuth(III) complexes with derivatives of tropolones and thiosemicarbazones Journal of Cancer Research and Clinical Oncology. 121. DOI: 10.1007/Bf02572162  0.37
1995 Diemer R, Keppler BK, Dittes U, Nuber B, Seifried V, Opferkuch W. Preparation and Characterization of Biologically Active Bismuth(III) Tropolonato Complexes Chemische Berichte. 128: 335-342. DOI: 10.1002/Cber.19951280404  0.415
1995 Galanski M, Keppler BK, Nuber B. First Isolation of an Enol of a Carboxylic Acid by Complexation to an (Ethane‐1,2‐diamine)‐platinum(II) Fragment Angewandte Chemie. 34: 1103-1104. DOI: 10.1002/Anie.199511031  0.354
1995 Galanski M, Keppler BK, Nuber B. Erstmalige Isolierung des Enols einer Carbonsäure durch Komplexierung an eine (Ethan-1,2-diamin)platin(II)-Einheit† Angewandte Chemie. 107: 1220-1221. DOI: 10.1002/Ange.19951071021  0.3
1994 Keppler BK, Hartmann M. New tumor-inhibiting metal complexes. Chemistry and antitumor properties. Metal-Based Drugs. 1: 145-149. PMID 18476225 DOI: 10.1155/Mbd.1994.145  0.34
1994 Dhubhghaill OMN, Hagen WR, Keppler BK, Lipponer K, Sadler PJ. Aquation of the anticancer complex trans-[RuCl4(Him)2]–(Him = imidazole) Journal of the Chemical Society-Dalton Transactions. 3305-3310. DOI: 10.1039/Dt9940003305  0.333
1994 Comba P, Jakob H, Nuber B, Keppler BK. Solution Structures and Isomer Distributions of Bis(.beta.-diketonato) Complexes of Titanium(IV) and Cobalt(III) Inorganic Chemistry. 33: 3396-3400. DOI: 10.1021/Ic00093A031  0.323
1994 Bloemink MJ, Keppler BK, Zahn H, Dorenbos JP, Heetebrij RJ, Reedijk J. New Antitumor Platinum Compounds Linked to Amino Phosphonic Acids Which Lose the Phosphonate and Tertiary Amine Ligand upon Binding to Nucleic Acids Inorganic Chemistry. 33: 1127-1132. DOI: 10.1021/Ic00084A026  0.424
1994 Gund A, Keppler BK. Structure of an Antineoplastic Platinum Complex with a Bipyridyl–Crown Ether Angewandte Chemie. 33: 186-188. DOI: 10.1002/Anie.199401861  0.36
1993 Lopez-Garzon R, Gutierrez-Valero MD, Godino-Salido ML, Keppler BK, Nuber B. SPECTROSCOPIC STUDIES OF METAL-PYRIMIDINE COMPLEXES. CRYSTAL STRUCTURES OF 4,6-DIMETHYL-2-THIOPYRIMIDINE COMPLEXES WITH Zn(II) AND Cd(II) Journal of Coordination Chemistry. 30: 111-123. DOI: 10.1080/00958979308024663  0.333
1993 Kratz F, Messori L, Keppler BK. Interaction of the antitumour ruthenium(III) complex trans-indazolium[tetrachlorobisindazoleruthenate(III)] with apotransferrin Journal of Inorganic Biochemistry. 51: 435. DOI: 10.1016/0162-0134(93)85464-J  0.378
1993 Einhäuser TJ, Keppler BK. ICP-AES measurement of DNA metal binding of new tumor-inhibiting titanium and ruthenium compounds Journal of Inorganic Biochemistry. 51: 434. DOI: 10.1016/0162-0134(93)85463-I  0.316
1993 Bloemink MJ, Dorenbos JP, Keppler BK, Reedijk J, Zahn H. Understanding the molecular mechanism of platinum antitumor complexes containing aminophosphonic ligands. Journal of Inorganic Biochemistry. 51: 419. DOI: 10.1016/0162-0134(93)85448-H  0.383
1992 Galeano A, Berger MR, Keppler BK. Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines. Cancer Chemotherapy and Pharmacology. 30: 131-138. PMID 1600593 DOI: 10.1007/Bf00686405  0.347
1992 Seelig MH, Berger MR, Keppler BK. Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats. Journal of Cancer Research and Clinical Oncology. 118: 195-200. PMID 1548284 DOI: 10.1007/Bf01410134  0.3
1992 Kratz F, Nuber B, Weiß J, Keppler BK. Synthesis and characterization of potential antitumour and antiviral gallium(III) complexes of N-heterocycles Polyhedron. 11: 487-498. DOI: 10.1016/S0277-5387(00)83206-4  0.412
1991 Zeller WJ, Frühauf S, Chen G, Keppler BK, Frei E, Kaufmann M. Chemoresistance in rat ovarian tumours. European Journal of Cancer and Clinical Oncology. 27: 62-67. PMID 1826445 DOI: 10.1016/0277-5379(91)90063-J  0.334
1990 Keppler BK, Berger MR, Heim ME. New tumor-inhibiting metal complexes. Cancer Treatment Reviews. 17: 261-277. PMID 2272042 DOI: 10.1016/0305-7372(90)90057-M  0.328
1990 Klenner T, Valenzuela-Paz P, Keppler BK, Scherf HR. Sensitivity of rodent osteosarcoma clones to platinum-containing phosphonic acid complexes in vitro. Journal of Cancer Research and Clinical Oncology. 116: 453-458. PMID 2229134 DOI: 10.1007/Bf01612993  0.371
1990 Keppler BK, Berger MR, Klenner T, Heim ME. Metal Complexes as Antitumour Agents Advances in Drug Research. 19: 243-310. DOI: 10.1016/B978-0-12-013319-2.50008-5  0.326
1987 Bischoff H, Berger MR, Keppler BK, Schmähl D. Efficacy of β-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats Journal of Cancer Research and Clinical Oncology. 113: 446-450. PMID 3624300 DOI: 10.1007/Bf00390038  0.327
1986 Keppler BK, Rupp W. Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). A representative of a new class of inorganic antitumor agents. Journal of Cancer Research and Clinical Oncology. 111: 166-168. PMID 3700462 DOI: 10.1007/Bf00400758  0.32
1983 Keller HJ, Keppler B, Schmähl D. Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium (IV) compounds. A new class of antineoplastic agents. Journal of Cancer Research and Clinical Oncology. 105: 109-110. PMID 6682104 DOI: 10.1007/Bf00391842  0.338
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