| Year |
Citation |
Score |
| 2014 |
Hüttel W, Spencer JB, Leadlay PF. Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8. PMID 24605157 DOI: 10.3762/Bjoc.10.34 |
0.316 |
|
| 2010 |
Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/Jbc.M110.107177 |
0.353 |
|
| 2010 |
Tosin M, Betancor L, Stephens E, Li WM, Spencer JB, Leadlay PF. Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46. PMID 20135665 DOI: 10.1002/Cbic.200900772 |
0.3 |
|
| 2010 |
Gaunt MJ, Yu J, Spencer JB. ChemInform Abstract: Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation. Cheminform. 33: no-no. DOI: 10.1002/chin.200202107 |
0.476 |
|
| 2010 |
Yu J, Spencer JB. ChemInform Abstract: New Insight into the Mechanism of Catalytic Hydrogenation Allows the Structure of the Key Intermediate in Asymmetric Hydrogenation to be Predicted. Cheminform. 30: no-no. DOI: 10.1002/chin.199917062 |
0.466 |
|
| 2010 |
YU J, SPENCER JB. ChemInform Abstract: Stereoselective Deoxygenation of myo-Inositol Monotosylates with Lithium Triethylborohydride. Cheminform. 27: no-no. DOI: 10.1002/chin.199637286 |
0.418 |
|
| 2009 |
Wu HC, Hamid SA, Yu JQ, Spencer JB. Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation. Journal of the American Chemical Society. 131: 9604-5. PMID 19555064 DOI: 10.1021/Ja903089F |
0.494 |
|
| 2009 |
Tosin M, Spiteller D, Spencer JB. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 1714-23. PMID 19507202 DOI: 10.1002/Cbic.200900093 |
0.35 |
|
| 2008 |
Smith L, Hong H, Spencer JB, Leadlay PF. Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75. PMID 19025863 DOI: 10.1002/Cbic.200800585 |
0.343 |
|
| 2008 |
Fan Q, Huang F, Leadlay PF, Spencer JB. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14. PMID 18802637 DOI: 10.1039/B808734B |
0.323 |
|
| 2008 |
Llewellyn NM, Spencer JB. Chemoenzymatic acylation of aminoglycoside antibiotics. Chemical Communications (Cambridge, England). 3786-8. PMID 18685777 DOI: 10.1039/B802248H |
0.326 |
|
| 2008 |
Truman AW, Fan Q, Röttgen M, Stegmann E, Leadlay PF, Spencer JB. The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function. Chemistry & Biology. 15: 476-84. PMID 18482700 DOI: 10.1016/J.Chembiol.2008.03.019 |
0.301 |
|
| 2008 |
Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45. PMID 18404760 DOI: 10.1002/Cbic.200700715 |
0.308 |
|
| 2008 |
Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF. Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem : a European Journal of Chemical Biology. 9: 150-6. PMID 18046685 DOI: 10.1002/Cbic.200700492 |
0.329 |
|
| 2008 |
Nudelman I, Chen L, Llewellyn NM, Sahraoui EH, Cherniavsky M, Spencer JB, Baasova T. Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain Advanced Synthesis and Catalysis. 350: 1682-1688. DOI: 10.1002/Adsc.200800229 |
0.318 |
|
| 2007 |
Llewellyn NM, Li Y, Spencer JB. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chemistry & Biology. 14: 379-86. PMID 17462573 DOI: 10.1016/J.Chembiol.2007.02.005 |
0.321 |
|
| 2007 |
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem : a European Journal of Chemical Biology. 8: 283-8. PMID 17206729 DOI: 10.1002/Cbic.200600371 |
0.339 |
|
| 2006 |
Neidig ML, Brown CD, Kavana M, Choroba OW, Spencer JB, Moran GR, Solomon EI. Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. Journal of Inorganic Biochemistry. 100: 2108-16. PMID 17070917 DOI: 10.1016/J.Jinorgbio.2006.08.021 |
0.332 |
|
| 2006 |
Neidig ML, Decker A, Choroba OW, Huang F, Kavana M, Moran GR, Spencer JB, Solomon EI. Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12966-73. PMID 16920789 DOI: 10.1073/Pnas.0605067103 |
0.351 |
|
| 2006 |
Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42. PMID 16897798 DOI: 10.1002/Cbic.200500474 |
0.344 |
|
| 2006 |
Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB. Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins. 65: 220-30. PMID 16894611 DOI: 10.1002/Prot.21076 |
0.329 |
|
| 2006 |
O'Hare HM, Huang F, Holding A, Choroba OW, Spencer JB. Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. Febs Letters. 580: 3445-50. PMID 16730004 DOI: 10.1016/J.Febslet.2006.05.018 |
0.338 |
|
| 2006 |
Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chemistry & Biology. 13: 475-84. PMID 16720268 DOI: 10.1016/J.Chembiol.2006.02.014 |
0.34 |
|
| 2006 |
O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 287-96. PMID 16638534 DOI: 10.1016/J.Chembiol.2006.01.003 |
0.321 |
|
| 2006 |
Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB. Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60. PMID 16632258 DOI: 10.1016/J.Chembiol.2006.01.013 |
0.37 |
|
| 2006 |
Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB. The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie (International Ed. in English). 45: 759-62. PMID 16370017 DOI: 10.1002/Anie.200503582 |
0.36 |
|
| 2006 |
Wright JA, Gaunt MJ, Spencer JB. Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 949-55. PMID 16144020 DOI: 10.1002/Chem.200400644 |
0.527 |
|
| 2005 |
Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53. PMID 16242657 DOI: 10.1016/J.Chembiol.2005.08.017 |
0.32 |
|
| 2005 |
Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chemistry & Biology. 12: 665-75. PMID 15975512 DOI: 10.1016/J.Chembiol.2005.04.010 |
0.576 |
|
| 2005 |
Tan YP, Khatua S, Jenkins SJ, Yu JQ, Spencer JB, King DA. Catalyst-induced changes in a substituted aromatic: A combined approach via experiment and theory Surface Science. 589: 173-183. DOI: 10.1016/J.Susc.2005.05.056 |
0.492 |
|
| 2004 |
Wu HC, Yu JQ, Spencer JB. Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor. Organic Letters. 6: 4675-8. PMID 15575658 DOI: 10.1021/Ol048227C |
0.502 |
|
| 2004 |
Li TL, Huang F, Haydock SF, Mironenko T, Leadlay PF, Spencer JB. Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chemistry & Biology. 11: 107-19. PMID 15113000 DOI: 10.1016/J.Chembiol.2004.01.001 |
0.303 |
|
| 2004 |
Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 427: 561-5. PMID 14765200 DOI: 10.1038/Nature02280 |
0.343 |
|
| 2004 |
Wabnitz TC, Yu JQ, Spencer JB. Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 484-93. PMID 14735517 DOI: 10.1002/Chem.200305407 |
0.549 |
|
| 2003 |
Wabnitz TC, Spencer JB. A general, Brønsted acid-catalyzed hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles. Organic Letters. 5: 2141-4. PMID 12790549 DOI: 10.1021/Ol034596H |
0.352 |
|
| 2003 |
Yu JQ, Wu HC, Ramarao C, Spencer JB, Ley SV. Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones. Chemical Communications (Cambridge, England). 678-9. PMID 12703769 DOI: 10.1039/B300074P |
0.522 |
|
| 2003 |
Wabnitz TC, Yu J, Spencer JB. A General, Polymer-Supported Acid Catalyzed Hetero-Michael Addition. Cheminform. 34. DOI: 10.1055/S-2003-39292 |
0.519 |
|
| 2002 |
Huang F, Li Y, Yu J, Spencer JB. Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine. Chemical Communications (Cambridge, England). 2860-1. PMID 12478783 DOI: 10.1039/B209799K |
0.485 |
|
| 2002 |
Yu J, Gaunt MJ, Spencer JB. Convenient preparation of trans-arylalkenes via palladium(II)-catalyzed isomerization of cis-arylalkenes. The Journal of Organic Chemistry. 67: 4627-9. PMID 12076172 DOI: 10.1021/Jo015880U |
0.611 |
|
| 2002 |
Wabnitz TC, Spencer JB. Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction Tetrahedron Letters. 43: 3891-3894. DOI: 10.1016/S0040-4039(02)00654-8 |
0.326 |
|
| 2001 |
Gaunt MJ, Yu J, Spencer JB. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation. Chemical Communications (Cambridge, England). 1844-5. PMID 12240343 DOI: 10.1039/B103066N |
0.626 |
|
| 2001 |
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB. Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics. Chemical Communications (Cambridge, England). 1752-3. PMID 12240298 DOI: 10.1039/B103548G |
0.327 |
|
| 2001 |
Li TL, Choroba OW, Hong H, Williams DH, Spencer JB. Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine. Chemical Communications (Cambridge, England). 2156-7. PMID 12240210 DOI: 10.1039/B106638B |
0.333 |
|
| 2001 |
Gaunt MJ, Spencer JB. Derailing the Wacker oxidation: development of a palladium-catalyzed amidation reaction. Organic Letters. 3: 25-8. PMID 11429862 DOI: 10.1021/Ol0066882 |
0.555 |
|
| 2001 |
Yu J, Spencer JB. Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: Two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics Tetrahedron Letters. 42: 4219-4221. DOI: 10.1016/S0040-4039(01)00612-8 |
0.531 |
|
| 2001 |
Wright JA, Yu J, Spencer JB. Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ Tetrahedron Letters. 42: 4033-4036. DOI: 10.1016/S0040-4039(01)00563-9 |
0.509 |
|
| 2000 |
Papageorgiou EA, Gaunt MJ, Yu JQ, Spencer JB. Selective hydrogenolysis of novel benzyl carbamate protecting groups Organic Letters. 2: 1049-51. PMID 10804551 DOI: 10.1021/Ol005589L |
0.612 |
|
| 2000 |
Kirkpatrick PN, Scaife W, Hallis TM, Liu HW, Spencer JB, Williams DH. Characterisation of a sugar epimerase enzyme involved in the biosynthesis of a vancomycin-group antibiotic Chemical Communications. 1565-1566. DOI: 10.1039/B004463F |
0.332 |
|
| 1999 |
Yu J, Whitney PS, Spencer JB. Direct comparison between the mechanism of hydrometalation and β- elimination in heterogeneous and homogeneous hydrogenation Journal of Molecular Catalysis a: Chemical. 146: 199-210. DOI: 10.1016/S1381-1169(99)00102-8 |
0.443 |
|
| 1999 |
Gaunt MJ, Boschetti CE, Yu J, Spencer JB. Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids Tetrahedron Letters. 40: 1803-1806. DOI: 10.1016/S0040-4039(99)00014-3 |
0.64 |
|
| 1999 |
Yu J, Spencer JB. Evidence for Direct Hydride Delivery from Formic Acid in Transfer Hydrogenation Chemistry - a European Journal. 5: 2237-2240. DOI: 10.1002/(Sici)1521-3765(19990802)5:8<2237::Aid-Chem2237>3.0.Co;2-O |
0.512 |
|
| 1998 |
Yu J, Spencer JB. Heterogeneous transfer hydrogenation involves pairwise hydrogen transfer from the same position of two molecules of formic acid Chemical Communications. 1935-1936. DOI: 10.1039/A803809K |
0.523 |
|
| 1998 |
Gaunt MJ, Yu J, Spencer JB. Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis The Journal of Organic Chemistry. 63: 4172-4173. DOI: 10.1021/Jo980823V |
0.649 |
|
| 1998 |
Yu J, Spencer JB. New insight into the mechanism of catalytic hydrogenation allows the structure of the key intermediate in asymmetric hydrogenation to be predicted Tetrahedron. 54: 15821-15832. DOI: 10.1016/S0040-4020(98)00992-2 |
0.538 |
|
| 1998 |
Gaunt MJ, Yu J, Spencer JB. Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis Journal of Organic Chemistry. 63: 4172-4173. |
0.465 |
|
| 1997 |
Yu J, Spencer JB. First Evidence That the Mechanism of Catalytic Hydrogenation with Homogeneous Palladium and Rhodium Catalysts Is Strongly Influenced by Substrate Polarity Journal of the American Chemical Society. 119: 5257-5258. DOI: 10.1021/Ja964179I |
0.511 |
|
| 1996 |
Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM. Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. Biochemistry. 35: 12267-74. PMID 8823160 DOI: 10.1021/Bi960422E |
0.635 |
|
| 1996 |
Yu J, Spencer JB. Stereoselective deoxygenation of myo-inositol monotosylates with lithium triethylborohydride Journal of Organic Chemistry. 61: 3234-3235. DOI: 10.1021/Jo960413B |
0.472 |
|
| 1996 |
Stolowich NJ, Wang J, Spencer JB, Santander PJ, Roessner CA, Scott IA. Absolute stereochemistry of precorrin-3x and its relevance to the dichotomy of ring contraction mechanism in vitamin B12 biosynthesis Journal of the American Chemical Society. 118: 1657-1662. DOI: 10.1021/Ja952739S |
0.35 |
|
| 1995 |
Roessner CA, Spencer JB, Ozaki S, Min C, Atshaves BP, Nayar P, Anousis N, Stolowich NJ, Holderman MT, Scott AI. Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes. Protein Expression and Purification. 6: 155-63. PMID 7606163 DOI: 10.1006/prep.1995.1019 |
0.435 |
|
| 1994 |
Roessner CA, Spencer JB, Stolowich NJ, Wang J, Nayar GP, Santander PJ, Pichon C, Min C, Holderman MT, Scott AI. Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12. Chemistry & Biology. 1: 119-24. PMID 9383380 |
0.488 |
|
| 1994 |
Warren MJ, Bolt EL, Roessner CA, Scott AI, Spencer JB, Woodcock SC. Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein. The Biochemical Journal. 302: 837-44. PMID 7945210 |
0.409 |
|
| 1994 |
Spencer JB, Stolowich NJ, Santander PJ, Pichon C, Kajiwara M, Tokiwa S, Takatori K, Scott AI. Mechanism of the Ring Contraction Step in Vitamin B12 Biosynthesis: The Origin and Subsequent Fate of the Oxygen Functionalities in Precorrin-3x Journal of the American Chemical Society. 116: 4991-4992. DOI: 10.1021/ja00090a056 |
0.399 |
|
| 1993 |
Scott AI, Roessner CA, Stolowich NJ, Spencer JB, Min C, Ozaki SI. Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group. Febs Letters. 331: 105-8. PMID 8405386 DOI: 10.1016/0014-5793(93)80306-F |
0.459 |
|
| 1993 |
Spencer JB, Stolowich NJ, Roessner CA, Scott AI. The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase. Febs Letters. 335: 57-60. PMID 8243665 DOI: 10.1016/0014-5793(93)80438-Z |
0.414 |
|
| 1993 |
Spencer JB, Stolowich NJ, Roessner CA, Min C, Scott AI. Biosynthesis of vitamin B12: ring contraction is preceded by incorporation of molecular oxygen into precorrin-3 Journal of the American Chemical Society. 115: 11610-11611. DOI: 10.1021/ja00077a075 |
0.391 |
|
| 1993 |
Min C, Atshaves BP, Roessner CA, Stolowich NJ, Spencer JB, Scott AI. Isolation, structure, and genetically engineered synthesis of precorrin- 5, the pentamethylated intermediate of vitamin B12 biosynthesis Journal of the American Chemical Society. 115: 10380-10381. DOI: 10.1021/Ja00075A072 |
0.457 |
|
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