Jonathan B. Spencer, Ph.D. - Publications

Affiliations: 
1994-2008 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
Area:
biosynthesis of antibiotics

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Hüttel W, Spencer JB, Leadlay PF. Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8. PMID 24605157 DOI: 10.3762/bjoc.10.34  1
2010 Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/jbc.M110.107177  1
2010 Tosin M, Betancor L, Stephens E, Li WM, Spencer JB, Leadlay PF. Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46. PMID 20135665 DOI: 10.1002/cbic.200900772  1
2010 Sandercock AM, Charles EH, Scaife W, Kirkpatrick PN, O'Brien SW, Papageorgiou EA, Spencer JB, Williams DH. ChemInform Abstract: Biosynthesis of the Di-meta-hydroxyphenylglycine Constituent of the Vancomycin-Group Antibiotic Chloroeremomycin. Cheminform. 32: no-no. DOI: 10.1002/chin.200143231  0.44
2009 Wu HC, Hamid SA, Yu JQ, Spencer JB. Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation. Journal of the American Chemical Society. 131: 9604-5. PMID 19555064 DOI: 10.1021/ja903089f  1
2009 Truman AW, Dias MV, Wu S, Blundell TL, Huang F, Spencer JB. Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chemistry & Biology. 16: 676-85. PMID 19549605 DOI: 10.1016/j.chembiol.2009.04.013  1
2009 Tosin M, Spiteller D, Spencer JB. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 1714-23. PMID 19507202 DOI: 10.1002/cbic.200900093  1
2009 Li TL, Spiteller D, Spencer JB. Identification of a pentaketide stilbene produced by a type III polyketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 896-901. PMID 19266535 DOI: 10.1002/cbic.200800840  1
2008 Smith L, Hong H, Spencer JB, Leadlay PF. Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75. PMID 19025863 DOI: 10.1002/cbic.200800585  1
2008 Fan Q, Huang F, Leadlay PF, Spencer JB. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14. PMID 18802637 DOI: 10.1039/b808734b  1
2008 Llewellyn NM, Spencer JB. Chemoenzymatic acylation of aminoglycoside antibiotics. Chemical Communications (Cambridge, England). 3786-8. PMID 18685777 DOI: 10.1039/b802248h  1
2008 Holding AN, Spencer JB. Investigation into the mechanism of phenolic couplings during the biosynthesis of glycopeptide antibiotics. Chembiochem : a European Journal of Chemical Biology. 9: 2209-14. PMID 18677741 DOI: 10.1002/cbic.200800303  1
2008 Hong H, Spiteller D, Spencer JB. Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization. Angewandte Chemie (International Ed. in English). 47: 6028-32. PMID 18613185 DOI: 10.1002/anie.200801100  1
2008 Truman AW, Fan Q, Röttgen M, Stegmann E, Leadlay PF, Spencer JB. The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function. Chemistry & Biology. 15: 476-84. PMID 18482700 DOI: 10.1016/j.chembiol.2008.03.019  1
2008 Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45. PMID 18404760 DOI: 10.1002/cbic.200700715  1
2008 Tran L, Tosin M, Spencer JB, Leadlay PF, Weissman KJ. Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 9: 905-15. PMID 18348128 DOI: 10.1002/cbic.200700738  1
2008 Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF. Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem : a European Journal of Chemical Biology. 9: 150-6. PMID 18046685 DOI: 10.1002/cbic.200700492  1
2008 Deng H, Huang FL, Naismith JH, O'Hagan D, Spencer JB, Zhu X. Biological Fluorination in Streptomyces cattleya: The Fluorinase Fluorine and Health. 761-777. DOI: 10.1016/B978-0-444-53086-8.00018-7  1
2008 Nudelman I, Chen L, Llewellyn NM, Sahraoui EH, Cherniavsky M, Spencer JB, Baasova T. Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain Advanced Synthesis and Catalysis. 350: 1682-1688. DOI: 10.1002/adsc.200800229  1
2007 Llewellyn NM, Spencer JB. Biological chemistry: enzymes line up for assembly. Nature. 448: 755-6. PMID 17700681 DOI: 10.1038/448755a  1
2007 Llewellyn NM, Li Y, Spencer JB. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chemistry & Biology. 14: 379-86. PMID 17462573 DOI: 10.1016/j.chembiol.2007.02.005  1
2007 Truman AW, Huang F, Llewellyn NM, Spencer JB. Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin. Angewandte Chemie (International Ed. in English). 46: 1462-4. PMID 17226887 DOI: 10.1002/anie.200604194  1
2007 Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem : a European Journal of Chemical Biology. 8: 283-8. PMID 17206729 DOI: 10.1002/cbic.200600371  1
2006 Llewellyn NM, Spencer JB. Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. Natural Product Reports. 23: 864-74. PMID 17119636 DOI: 10.1039/b604709m  1
2006 Neidig ML, Brown CD, Kavana M, Choroba OW, Spencer JB, Moran GR, Solomon EI. Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. Journal of Inorganic Biochemistry. 100: 2108-16. PMID 17070917 DOI: 10.1016/j.jinorgbio.2006.08.021  1
2006 Truman AW, Robinson L, Spencer JB. Identification of a deacetylase involved in the maturation of teicoplanin. Chembiochem : a European Journal of Chemical Biology. 7: 1670-5. PMID 17009278 DOI: 10.1002/cbic.200600308  1
2006 Neidig ML, Decker A, Choroba OW, Huang F, Kavana M, Moran GR, Spencer JB, Solomon EI. Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12966-73. PMID 16920789 DOI: 10.1073/pnas.0605067103  1
2006 Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42. PMID 16897798 DOI: 10.1002/cbic.200500474  1
2006 Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB. Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins. 65: 220-30. PMID 16894611 DOI: 10.1002/prot.21076  1
2006 Gallimore AR, Spencer JB. Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin. Angewandte Chemie (International Ed. in English). 45: 4406-13. PMID 16767782 DOI: 10.1002/anie.200504284  1
2006 O'Hare HM, Huang F, Holding A, Choroba OW, Spencer JB. Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. Febs Letters. 580: 3445-50. PMID 16730004 DOI: 10.1016/j.febslet.2006.05.018  1
2006 Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chemistry & Biology. 13: 475-84. PMID 16720268 DOI: 10.1016/j.chembiol.2006.02.014  1
2006 O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 287-96. PMID 16638534 DOI: 10.1016/j.chembiol.2006.01.003  1
2006 Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 277-85. PMID 16638533 DOI: 10.1016/j.chembiol.2006.01.004  1
2006 Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB. Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60. PMID 16632258 DOI: 10.1016/j.chembiol.2006.01.013  1
2006 Wright JA, Gaunt MJ, Spencer JB. Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 949-55. PMID 16144020 DOI: 10.1002/chem.200400644  1
2005 Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53. PMID 16242657 DOI: 10.1016/j.chembiol.2005.08.017  1
2005 Bhatt A, Stark CB, Harvey BM, Gallimore AR, Demydchuk YA, Spencer JB, Staunton J, Leadlay PF. Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angewandte Chemie (International Ed. in English). 44: 7075-8. PMID 16217816 DOI: 10.1002/anie.200501757  1
2005 Spiteller D, Waterman CL, Spencer JB. A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue. Angewandte Chemie (International Ed. in English). 44: 7079-82. PMID 16208728 DOI: 10.1002/anie.200501670  1
2005 Hong H, Stinear T, Skelton P, Spencer JB, Leadlay PF. Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. Chemical Communications (Cambridge, England). 4306-8. PMID 16113730 DOI: 10.1039/b506835e  1
2005 Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chemistry & Biology. 12: 665-75. PMID 15975512 DOI: 10.1016/j.chembiol.2005.04.010  1
2005 Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. Organic & Biomolecular Chemistry. 3: 1410-8. PMID 15827636 DOI: 10.1039/b501199j  1
2005 Hong H, Spencer JB, Porter JL, Leadlay PF, Stinear T. A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 6: 643-8. PMID 15750996 DOI: 10.1002/cbic.200400339  1
2005 Tan YP, Khatua S, Jenkins SJ, Yu JQ, Spencer JB, King DA. Catalyst-induced changes in a substituted aromatic: A combined approach via experiment and theory Surface Science. 589: 173-183. DOI: 10.1016/j.susc.2005.05.056  0.64
2004 Wu HC, Yu JQ, Spencer JB. Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor. Organic Letters. 6: 4675-8. PMID 15575658 DOI: 10.1021/ol048227c  1
2004 Li TL, Huang F, Haydock SF, Mironenko T, Leadlay PF, Spencer JB. Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chemistry & Biology. 11: 107-19. PMID 15113000 DOI: 10.1016/j.chembiol.2004.01.001  1
2004 Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 427: 561-5. PMID 14765200 DOI: 10.1038/nature02280  1
2004 Wabnitz TC, Yu JQ, Spencer JB. Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 484-93. PMID 14735517 DOI: 10.1002/chem.200305407  1
2003 Hong H, Gates PJ, Staunton J, Stinear T, Cole ST, Leadlay PF, Spencer JB. Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. Chemical Communications (Cambridge, England). 2822-3. PMID 14651122  1
2003 Wabnitz TC, Spencer JB. A general, Brønsted acid-catalyzed hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles. Organic Letters. 5: 2141-4. PMID 12790549 DOI: 10.1021/ol034596h  1
2003 Yu JQ, Wu HC, Ramarao C, Spencer JB, Ley SV. Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones. Chemical Communications (Cambridge, England). 678-9. PMID 12703769  1
2003 Paz FAA, Gates PJ, Fowler S, Gallimore A, Harvey B, Lopes NP, Stark CBW, Staunton J, Klinowski J, Spencer JB. Sodium monensin dihydrate Acta Crystallographica Section E: Structure Reports Online. 59: m1050-m1052. DOI: 10.1107/S1600536803022980  1
2003 Wabnitz TC, Yu JQ, Spencer JB. A general, polymer-supported acid catalyzed hetero-Michael addition Synlett. 1070-1072.  1
2002 Huang F, Li Y, Yu J, Spencer JB. Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine. Chemical Communications (Cambridge, England). 2860-1. PMID 12478783  1
2002 Yu J, Gaunt MJ, Spencer JB. Convenient preparation of trans-arylalkenes via palladium(II)-catalyzed isomerization of cis-arylalkenes. The Journal of Organic Chemistry. 67: 4627-9. PMID 12076172 DOI: 10.1021/jo015880u  1
2002 Wabnitz TC, Spencer JB. Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction Tetrahedron Letters. 43: 3891-3894. DOI: 10.1016/S0040-4039(02)00654-8  1
2001 Gaunt MJ, Yu J, Spencer JB. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation. Chemical Communications (Cambridge, England). 1844-5. PMID 12240343  1
2001 Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB. Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics. Chemical Communications (Cambridge, England). 1752-3. PMID 12240298 DOI: 10.1039/b103548g  1
2001 Li TL, Choroba OW, Hong H, Williams DH, Spencer JB. Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine. Chemical Communications (Cambridge, England). 2156-7. PMID 12240210 DOI: 10.1039/B106638B  1
2001 Gaunt MJ, Spencer JB. Derailing the Wacker oxidation: development of a palladium-catalyzed amidation reaction. Organic Letters. 3: 25-8. PMID 11429862 DOI: 10.1021/ol0066882  1
2001 Yu J, Spencer JB. Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: Two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics Tetrahedron Letters. 42: 4219-4221. DOI: 10.1016/S0040-4039(01)00612-8  1
2001 Wright JA, Yu J, Spencer JB. Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ Tetrahedron Letters. 42: 4033-4036. DOI: 10.1016/S0040-4039(01)00563-9  1
2001 Sandercock AM, Charles EH, Scaife W, Kirkpatrick PN, O'Brien SW, Papageorgiou EA, Spencer JB, Williams DH. Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin Chemical Communications. 1252-1253.  1
2000 Papageorgiou EA, Gaunt MJ, Yu JQ, Spencer JB. Selective hydrogenolysis of novel benzyl carbamate protecting groups Organic Letters. 2: 1049-51. PMID 10804551 DOI: 10.1021/ol005589l  1
2000 O'Brien DP, Kirkpatrick PN, O'Brien SW, Staroske T, Richardson TI, Evans DA, Hopkinson A, Spencer JB, Williams DH. Expression and assay of an N-methyltransferase involved in the biosynthesis of a vancomycin group antibiotic Chemical Communications. 103-104. DOI: 10.1039/A907953J  1
2000 Choroba OW, Williams DH, Spencer JB. Biosynthesis of the vancomycin group of antibiotics: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine [2] Journal of the American Chemical Society. 122: 5389-5390. DOI: 10.1021/ja000076v  1
2000 Kirkpatrick PN, Scaife W, Hallis TM, Liu HW, Spencer JB, Williams DH. Characterisation of a sugar epimerase enzyme involved in the biosynthesis of a vancomycin-group antibiotic Chemical Communications. 1565-1566.  1
1999 Yu J, Whitney PS, Spencer JB. Direct comparison between the mechanism of hydrometalation and β- elimination in heterogeneous and homogeneous hydrogenation Journal of Molecular Catalysis a: Chemical. 146: 199-210. DOI: 10.1016/S1381-1169(99)00102-8  1
1999 Gaunt MJ, Boschetti CE, Yu J, Spencer JB. Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids Tetrahedron Letters. 40: 1803-1806. DOI: 10.1016/S0040-4039(99)00014-3  1
1999 Yu J, Spencer JB. Evidence for direct hydride delivery from formic acid in transfer hydrogenation Chemistry - a European Journal. 5: 2237-2240.  1
1998 Yu J, Spencer JB. New insight into the mechanism of catalytic hydrogenation allows the structure of the key intermediate in asymmetric hydrogenation to be predicted Tetrahedron. 54: 15821-15832.  1
1998 Jinquan Y, Spencer JB. Heterogeneous transfer hydrogenation involves pairwise hydrogen transfer from the same position of two molecules of formic acid Chemical Communications. 1935-1936.  1
1998 Gaunt MJ, Yu J, Spencer JB. Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis Journal of Organic Chemistry. 63: 4172-4173.  1
1998 Yu J, Spencer JB. Discovery that quinoline and triphenylphosphine alter the electronic properties of hydrogenation catalysts Chemical Communications. 1103-1104.  1
1996 Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM. Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. Biochemistry. 35: 12267-74. PMID 8823160 DOI: 10.1021/bi960422e  0.32
1996 Yu J, Spencer JB. Stereoselective deoxygenation of myo-inositol monotosylates with lithium triethylborohydride Journal of Organic Chemistry. 61: 3234-3235. DOI: 10.1021/jo960413b  1
1996 Stolowich NJ, Wang J, Spencer JB, Santander PJ, Roessner CA, Scott IA. Absolute stereochemistry of precorrin-3x and its relevance to the dichotomy of ring contraction mechanism in vitamin B12 biosynthesis Journal of the American Chemical Society. 118: 1657-1662. DOI: 10.1021/ja952739s  0.76
1995 Roessner CA, Spencer JB, Ozaki S, Min C, Atshaves BP, Nayar P, Anousis N, Stolowich NJ, Holderman MT, Scott AI. Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes. Protein Expression and Purification. 6: 155-63. PMID 7606163 DOI: 10.1006/prep.1995.1019  0.76
1994 Roessner CA, Spencer JB, Stolowich NJ, Wang J, Nayar GP, Santander PJ, Pichon C, Min C, Holderman MT, Scott AI. Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12. Chemistry & Biology. 1: 119-24. PMID 9383380  0.76
1994 Warren MJ, Bolt EL, Roessner CA, Scott AI, Spencer JB, Woodcock SC. Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein. The Biochemical Journal. 302: 837-44. PMID 7945210  0.76
1994 Spencer JB, Stolowich NJ, Santander PJ, Pichon C, Kajiwara M, Tokiwa S, Takatori K, Scott AI. Mechanism of the ring contraction step in vitamin B12 biosynthesis: The origin and subsequent fate of the oxygen functionalities in precorrin-3x Journal of the American Chemical Society. 116: 4991-4992.  0.76
1993 Jordan PM, Spencer JB. The biosynthesis of tetraketides: enzymology, mechanism and molecular programming. Biochemical Society Transactions. 21: 222-8. PMID 8449301  0.32
1993 Scott AI, Roessner CA, Stolowich NJ, Spencer JB, Min C, Ozaki SI. Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group. Febs Letters. 331: 105-8. PMID 8405386 DOI: 10.1016/0014-5793(93)80306-F  0.76
1993 Spencer JB, Stolowich NJ, Roessner CA, Scott AI. The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase. Febs Letters. 335: 57-60. PMID 8243665 DOI: 10.1016/0014-5793(93)80438-Z  0.76
1993 Min C, Atshaves BP, Roessner CA, Stolowich NJ, Spencer JB, Scott AI. Isolation, structure, and genetically engineered synthesis of precorrin- 5, the pentamethylated intermediate of vitamin B12 biosynthesis Journal of the American Chemical Society. 115: 10380-10381. DOI: 10.1021/ja00075a072  0.76
1993 Min C, Atshaves BP, Roessner CA, Stolowich NJ, Spencer JB, Ian Scott A. Isolation, structure, and genetically engineered synthesis of precorrin-5, the pentamethylated intermediate of vitamin B12 biosynthesis Journal of the American Chemical Society. 115: 10378-10379.  0.76
1993 Spencer JB, Stolowich NJ, Roessner CA, Min C, Ian Scott A. Biosynthesis of vitamin B12: Ring contraction is preceded by incorporation of molecular oxygen into preconin-3 Journal of the American Chemical Society. 115: 11610-11611.  0.76
1992 Spencer JB, Jordan PM. Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum. The Biochemical Journal. 288: 839-46. PMID 1471999  0.32
1992 Spencer JB, Jordan PM. Investigation of the mechanism and steric course of the reaction catalyzed by 6-methylsalicylic acid synthase from Penicillium patulum using (R)-[1-13C;2-2H]- and (S)-[1-13C;2-2H]malonates. Biochemistry. 31: 9107-16. PMID 1390697  0.32
1992 Spencer JB, Jordan PM. Stereospecific elimination of hydrogen atoms with opposite absolute orientations during the biosynthesis of orsellinic acid from chiral malonates in Penicillium cyclopium Journal of the Chemical Society, Chemical Communications. 646-648. DOI: 10.1039/C39920000646  0.32
1991 Jordan PM, Spencer JB. Mechanistic and stereochemical investigation of fatty acid and polyketide biosynthesis using chiral malonates Tetrahedron. 47: 6015-6028. DOI: 10.1016/S0040-4020(01)86493-0  0.32
1990 Spencer JB, Jordan PM. Use of chiral malonates to determine the absolute configuration of the hydrogen atoms eliminated during the formation of 6-methylsalicylic acid by 6-methylsalicylic acid synthase from Penicillium patulum Journal of the Chemical Society, Chemical Communications. 1704-1706. DOI: 10.1039/C39900001704  0.32
1990 Jordan PM, Spencer JB. Stereospecific manipulation of hydrogen atoms with opposite absolute orientations during the biosynthesis of the polyketide 6-methylsalicylic acid from chiral malonates in Penicillium patulum Journal of the Chemical Society, Chemical Communications. 238-242. DOI: 10.1039/C39900000238  0.32
1986 Jordan PM, Spencer JB, Corina DL. The synthesis of chiral malonates and the determination of their chirality using fatty acid synthase and mass spectrometry Journal of the Chemical Society, Chemical Communications. 911-913. DOI: 10.1039/C39860000911  0.32
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