Jonathan B. Spencer, Ph.D. - Publications

1994-2008 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
biosynthesis of antibiotics

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Hüttel W, Spencer JB, Leadlay PF. Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8. PMID 24605157 DOI: 10.3762/Bjoc.10.34  0.316
2010 Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/Jbc.M110.107177  0.353
2010 Tosin M, Betancor L, Stephens E, Li WM, Spencer JB, Leadlay PF. Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46. PMID 20135665 DOI: 10.1002/Cbic.200900772  0.3
2010 Gaunt MJ, Yu J, Spencer JB. ChemInform Abstract: Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation. Cheminform. 33: no-no. DOI: 10.1002/chin.200202107  0.478
2010 Yu J, Spencer JB. ChemInform Abstract: New Insight into the Mechanism of Catalytic Hydrogenation Allows the Structure of the Key Intermediate in Asymmetric Hydrogenation to be Predicted. Cheminform. 30: no-no. DOI: 10.1002/chin.199917062  0.468
2010 YU J, SPENCER JB. ChemInform Abstract: Stereoselective Deoxygenation of myo-Inositol Monotosylates with Lithium Triethylborohydride. Cheminform. 27: no-no. DOI: 10.1002/chin.199637286  0.42
2009 Wu HC, Hamid SA, Yu JQ, Spencer JB. Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation. Journal of the American Chemical Society. 131: 9604-5. PMID 19555064 DOI: 10.1021/Ja903089F  0.496
2009 Tosin M, Spiteller D, Spencer JB. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 1714-23. PMID 19507202 DOI: 10.1002/Cbic.200900093  0.35
2008 Smith L, Hong H, Spencer JB, Leadlay PF. Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75. PMID 19025863 DOI: 10.1002/Cbic.200800585  0.342
2008 Fan Q, Huang F, Leadlay PF, Spencer JB. The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14. PMID 18802637 DOI: 10.1039/B808734B  0.323
2008 Llewellyn NM, Spencer JB. Chemoenzymatic acylation of aminoglycoside antibiotics. Chemical Communications (Cambridge, England). 3786-8. PMID 18685777 DOI: 10.1039/B802248H  0.326
2008 Truman AW, Fan Q, Röttgen M, Stegmann E, Leadlay PF, Spencer JB. The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function. Chemistry & Biology. 15: 476-84. PMID 18482700 DOI: 10.1016/J.Chembiol.2008.03.019  0.301
2008 Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45. PMID 18404760 DOI: 10.1002/Cbic.200700715  0.308
2008 Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF. Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem : a European Journal of Chemical Biology. 9: 150-6. PMID 18046685 DOI: 10.1002/Cbic.200700492  0.328
2008 Nudelman I, Chen L, Llewellyn NM, Sahraoui EH, Cherniavsky M, Spencer JB, Baasova T. Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain Advanced Synthesis and Catalysis. 350: 1682-1688. DOI: 10.1002/Adsc.200800229  0.317
2007 Llewellyn NM, Li Y, Spencer JB. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chemistry & Biology. 14: 379-86. PMID 17462573 DOI: 10.1016/J.Chembiol.2007.02.005  0.321
2007 Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. Chembiochem : a European Journal of Chemical Biology. 8: 283-8. PMID 17206729 DOI: 10.1002/Cbic.200600371  0.339
2006 Neidig ML, Brown CD, Kavana M, Choroba OW, Spencer JB, Moran GR, Solomon EI. Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. Journal of Inorganic Biochemistry. 100: 2108-16. PMID 17070917 DOI: 10.1016/J.Jinorgbio.2006.08.021  0.332
2006 Neidig ML, Decker A, Choroba OW, Huang F, Kavana M, Moran GR, Spencer JB, Solomon EI. Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12966-73. PMID 16920789 DOI: 10.1073/Pnas.0605067103  0.351
2006 Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42. PMID 16897798 DOI: 10.1002/Cbic.200500474  0.344
2006 Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB. Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins. 65: 220-30. PMID 16894611 DOI: 10.1002/Prot.21076  0.329
2006 O'Hare HM, Huang F, Holding A, Choroba OW, Spencer JB. Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. Febs Letters. 580: 3445-50. PMID 16730004 DOI: 10.1016/J.Febslet.2006.05.018  0.337
2006 Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chemistry & Biology. 13: 475-84. PMID 16720268 DOI: 10.1016/J.Chembiol.2006.02.014  0.339
2006 O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chemistry & Biology. 13: 287-96. PMID 16638534 DOI: 10.1016/J.Chembiol.2006.01.003  0.321
2006 Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB. Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60. PMID 16632258 DOI: 10.1016/J.Chembiol.2006.01.013  0.37
2006 Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB. The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie (International Ed. in English). 45: 759-62. PMID 16370017 DOI: 10.1002/Anie.200503582  0.36
2006 Wright JA, Gaunt MJ, Spencer JB. Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 949-55. PMID 16144020 DOI: 10.1002/Chem.200400644  0.528
2005 Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53. PMID 16242657 DOI: 10.1016/J.Chembiol.2005.08.017  0.32
2005 Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chemistry & Biology. 12: 665-75. PMID 15975512 DOI: 10.1016/J.Chembiol.2005.04.010  0.578
2005 Tan YP, Khatua S, Jenkins SJ, Yu JQ, Spencer JB, King DA. Catalyst-induced changes in a substituted aromatic: A combined approach via experiment and theory Surface Science. 589: 173-183. DOI: 10.1016/J.Susc.2005.05.056  0.494
2004 Wu HC, Yu JQ, Spencer JB. Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor. Organic Letters. 6: 4675-8. PMID 15575658 DOI: 10.1021/Ol048227C  0.504
2004 Li TL, Huang F, Haydock SF, Mironenko T, Leadlay PF, Spencer JB. Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chemistry & Biology. 11: 107-19. PMID 15113000 DOI: 10.1016/J.Chembiol.2004.01.001  0.303
2004 Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 427: 561-5. PMID 14765200 DOI: 10.1038/Nature02280  0.343
2004 Wabnitz TC, Yu JQ, Spencer JB. Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 484-93. PMID 14735517 DOI: 10.1002/Chem.200305407  0.551
2003 Wabnitz TC, Spencer JB. A general, Brønsted acid-catalyzed hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles. Organic Letters. 5: 2141-4. PMID 12790549 DOI: 10.1021/Ol034596H  0.352
2003 Yu JQ, Wu HC, Ramarao C, Spencer JB, Ley SV. Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones. Chemical Communications (Cambridge, England). 678-9. PMID 12703769 DOI: 10.1039/B300074P  0.524
2003 Wabnitz TC, Yu J, Spencer JB. A General, Polymer-Supported Acid Catalyzed Hetero-Michael Addition. Cheminform. 34. DOI: 10.1055/S-2003-39292  0.521
2002 Huang F, Li Y, Yu J, Spencer JB. Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine. Chemical Communications (Cambridge, England). 2860-1. PMID 12478783 DOI: 10.1039/B209799K  0.487
2002 Yu J, Gaunt MJ, Spencer JB. Convenient preparation of trans-arylalkenes via palladium(II)-catalyzed isomerization of cis-arylalkenes. The Journal of Organic Chemistry. 67: 4627-9. PMID 12076172 DOI: 10.1021/Jo015880U  0.613
2002 Wabnitz TC, Spencer JB. Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction Tetrahedron Letters. 43: 3891-3894. DOI: 10.1016/S0040-4039(02)00654-8  0.327
2001 Gaunt MJ, Yu J, Spencer JB. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation. Chemical Communications (Cambridge, England). 1844-5. PMID 12240343 DOI: 10.1039/B103066N  0.628
2001 Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB. Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics. Chemical Communications (Cambridge, England). 1752-3. PMID 12240298 DOI: 10.1039/B103548G  0.327
2001 Li TL, Choroba OW, Hong H, Williams DH, Spencer JB. Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine. Chemical Communications (Cambridge, England). 2156-7. PMID 12240210 DOI: 10.1039/B106638B  0.333
2001 Gaunt MJ, Spencer JB. Derailing the Wacker oxidation: development of a palladium-catalyzed amidation reaction. Organic Letters. 3: 25-8. PMID 11429862 DOI: 10.1021/Ol0066882  0.556
2001 Yu J, Spencer JB. Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: Two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics Tetrahedron Letters. 42: 4219-4221. DOI: 10.1016/S0040-4039(01)00612-8  0.532
2001 Wright JA, Yu J, Spencer JB. Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ Tetrahedron Letters. 42: 4033-4036. DOI: 10.1016/S0040-4039(01)00563-9  0.511
2000 Papageorgiou EA, Gaunt MJ, Yu JQ, Spencer JB. Selective hydrogenolysis of novel benzyl carbamate protecting groups Organic Letters. 2: 1049-51. PMID 10804551 DOI: 10.1021/Ol005589L  0.613
2000 Kirkpatrick PN, Scaife W, Hallis TM, Liu HW, Spencer JB, Williams DH. Characterisation of a sugar epimerase enzyme involved in the biosynthesis of a vancomycin-group antibiotic Chemical Communications. 1565-1566. DOI: 10.1039/B004463F  0.332
1999 Yu J, Whitney PS, Spencer JB. Direct comparison between the mechanism of hydrometalation and β- elimination in heterogeneous and homogeneous hydrogenation Journal of Molecular Catalysis a: Chemical. 146: 199-210. DOI: 10.1016/S1381-1169(99)00102-8  0.446
1999 Gaunt MJ, Boschetti CE, Yu J, Spencer JB. Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids Tetrahedron Letters. 40: 1803-1806. DOI: 10.1016/S0040-4039(99)00014-3  0.642
1999 Yu J, Spencer JB. Evidence for Direct Hydride Delivery from Formic Acid in Transfer Hydrogenation Chemistry - a European Journal. 5: 2237-2240. DOI: 10.1002/(Sici)1521-3765(19990802)5:8<2237::Aid-Chem2237>3.0.Co;2-O  0.514
1998 Yu J, Spencer JB. Heterogeneous transfer hydrogenation involves pairwise hydrogen transfer from the same position of two molecules of formic acid Chemical Communications. 1935-1936. DOI: 10.1039/A803809K  0.525
1998 Gaunt MJ, Yu J, Spencer JB. Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis The Journal of Organic Chemistry. 63: 4172-4173. DOI: 10.1021/Jo980823V  0.65
1998 Yu J, Spencer JB. New insight into the mechanism of catalytic hydrogenation allows the structure of the key intermediate in asymmetric hydrogenation to be predicted Tetrahedron. 54: 15821-15832. DOI: 10.1016/S0040-4020(98)00992-2  0.54
1998 Gaunt MJ, Yu J, Spencer JB. Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis Journal of Organic Chemistry. 63: 4172-4173.  0.467
1997 Yu J, Spencer JB. First Evidence That the Mechanism of Catalytic Hydrogenation with Homogeneous Palladium and Rhodium Catalysts Is Strongly Influenced by Substrate Polarity Journal of the American Chemical Society. 119: 5257-5258. DOI: 10.1021/Ja964179I  0.513
1996 Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM. Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. Biochemistry. 35: 12267-74. PMID 8823160 DOI: 10.1021/Bi960422E  0.635
1996 Yu J, Spencer JB. Stereoselective deoxygenation of myo-inositol monotosylates with lithium triethylborohydride Journal of Organic Chemistry. 61: 3234-3235. DOI: 10.1021/Jo960413B  0.474
1996 Stolowich NJ, Wang J, Spencer JB, Santander PJ, Roessner CA, Scott IA. Absolute stereochemistry of precorrin-3x and its relevance to the dichotomy of ring contraction mechanism in vitamin B12 biosynthesis Journal of the American Chemical Society. 118: 1657-1662. DOI: 10.1021/Ja952739S  0.35
1995 Roessner CA, Spencer JB, Ozaki S, Min C, Atshaves BP, Nayar P, Anousis N, Stolowich NJ, Holderman MT, Scott AI. Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes. Protein Expression and Purification. 6: 155-63. PMID 7606163 DOI: 10.1006/prep.1995.1019  0.435
1994 Roessner CA, Spencer JB, Stolowich NJ, Wang J, Nayar GP, Santander PJ, Pichon C, Min C, Holderman MT, Scott AI. Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12. Chemistry & Biology. 1: 119-24. PMID 9383380  0.488
1994 Warren MJ, Bolt EL, Roessner CA, Scott AI, Spencer JB, Woodcock SC. Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein. The Biochemical Journal. 302: 837-44. PMID 7945210  0.409
1994 Spencer JB, Stolowich NJ, Santander PJ, Pichon C, Kajiwara M, Tokiwa S, Takatori K, Scott AI. Mechanism of the Ring Contraction Step in Vitamin B12 Biosynthesis: The Origin and Subsequent Fate of the Oxygen Functionalities in Precorrin-3x Journal of the American Chemical Society. 116: 4991-4992. DOI: 10.1021/ja00090a056  0.399
1993 Scott AI, Roessner CA, Stolowich NJ, Spencer JB, Min C, Ozaki SI. Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group. Febs Letters. 331: 105-8. PMID 8405386 DOI: 10.1016/0014-5793(93)80306-F  0.458
1993 Spencer JB, Stolowich NJ, Roessner CA, Scott AI. The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase. Febs Letters. 335: 57-60. PMID 8243665 DOI: 10.1016/0014-5793(93)80438-Z  0.414
1993 Spencer JB, Stolowich NJ, Roessner CA, Min C, Scott AI. Biosynthesis of vitamin B12: ring contraction is preceded by incorporation of molecular oxygen into precorrin-3 Journal of the American Chemical Society. 115: 11610-11611. DOI: 10.1021/ja00077a075  0.391
1993 Min C, Atshaves BP, Roessner CA, Stolowich NJ, Spencer JB, Scott AI. Isolation, structure, and genetically engineered synthesis of precorrin- 5, the pentamethylated intermediate of vitamin B12 biosynthesis Journal of the American Chemical Society. 115: 10380-10381. DOI: 10.1021/Ja00075A072  0.457
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