Steven Victor Ley, Ph.D. - Publications

Affiliations: 
Chemsitry University of Cambridge, Cambridge, England, United Kingdom 
Area:
Organic Chemistry, Total Synthesis, Flow Chemistry
Website:
http://www.leygroup.ch.cam.ac.uk

288 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lesieur M, Battilocchio C, Labes R, Jacq J, Genicot C, Ley SV, Pasau P. Direct Oxidation of Csp -H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30485562 DOI: 10.1002/chem.201805657  1
2018 Chen Y, Leonardi M, Dingwall P, Labes R, Pasau P, Blakemore DC, Ley SV. Photochemical homologation for the preparation of aliphatic aldehydes in flow. The Journal of Organic Chemistry. PMID 30444967 DOI: 10.1021/acs.joc.8b02721  1
2018 Fitzpatrick DE, Maujean T, Evans A, Ley SV. Across-the-world automated optimization and continuous flow synthesis of pharmaceutical agents operating through a cloud-based server. Angewandte Chemie (International Ed. in English). PMID 30272384 DOI: 10.1002/anie.201809080  1
2018 Chen Y, Blakemore DC, Pasau P, Ley SV. Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor. Organic Letters. PMID 30270627 DOI: 10.1021/acs.orglett.8b02907  1
2018 Dingwall P, Greb A, Crespin LNS, Labes R, Musio B, Poh JS, Pasau P, Blakemore DC, Ley SV. C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow. Chemical Communications (Cambridge, England). PMID 30203830 DOI: 10.1039/c8cc06202a  1
2018 Ou X, Labes R, Battilocchio C, Ley SV. Preparation of homoallylic amines via a three-component coupling process. Organic & Biomolecular Chemistry. PMID 30183047 DOI: 10.1039/c8ob01831f  1
2018 Lima F, Grunenberg L, Rahman HBA, Labes R, Sedelmeier J, Ley SV. Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications (Cambridge, England). PMID 29767201 DOI: 10.1039/c8cc02169d  1
2018 Ritson DJ, Battilocchio C, Ley SV, Sutherland JD. Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry. Nature Communications. 9: 1821. PMID 29739945 DOI: 10.1038/s41467-018-04147-2  1
2017 Bomio C, Kabeshov MA, Lit AR, Lau SH, Ehlert J, Battilocchio C, Ley SV. Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids. Chemical Science. 8: 6071-6075. PMID 29619197 DOI: 10.1039/c7sc02264f  1
2017 Crespin LNS, Greb A, Blakemore DC, Ley SV. Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives. The Journal of Organic Chemistry. PMID 29121471 DOI: 10.1021/acs.joc.7b02146  1
2017 Greb A, Poh JS, Greed S, Battilocchio C, Pasau P, Blakemore DC, Ley SV. A New Versatile Route to Unstable Diazo Compounds via Oxadiazolines and Use In Aryl-Alkyl Cross-Coupling Reactions. Angewandte Chemie (International Ed. in English). PMID 29088512 DOI: 10.1002/anie.201710445  1
2017 Lima F, Sharma UK, Grunenberg L, Saha D, Johannsen S, Sedelmeier J, Van der Eycken EV, Ley SV. A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters. Angewandte Chemie (International Ed. in English). PMID 29024307 DOI: 10.1002/anie.201709690  1
2017 Crespin L, Biancalana L, Morack T, Blakemore DC, Ley SV. One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines. Organic Letters. PMID 28199120 DOI: 10.1021/acs.orglett.7b00101  1
2017 Poh JS, Makai S, von Keutz T, Tran DN, Battilocchio C, Pasau P, Ley SV. Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines. Angewandte Chemie (International Ed. in English). PMID 28075518 DOI: 10.1002/anie.201611067  1
2016 Poh JS, Lau SH, Dykes IG, Tran DN, Battilocchio C, Ley SV. A multicomponent approach for the preparation of homoallylic alcohols. Chemical Science. 7: 6803-6807. PMID 28042466 DOI: 10.1039/c6sc02581a  1
2016 Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, et al. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Science Advances. 2: e1600760. PMID 27757418 DOI: 10.1126/sciadv.1600760  1
2016 Lima F, Kabeshov MA, Tran DN, Battilocchio C, Sedelmeier J, Sedelmeier G, Schenkel B, Ley SV. Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow. Angewandte Chemie (International Ed. in English). PMID 27709749 DOI: 10.1002/anie.201605548  1
2016 Fenner S, Wilson ZE, Ley SV. The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27619732 DOI: 10.1002/chem.201603157  0.32
2016 Movsisyan M, Delbeke EI, Berton JK, Battilocchio C, Ley SV, Stevens CV. Taming hazardous chemistry by continuous flow technology. Chemical Society Reviews. PMID 27453961 DOI: 10.1039/c5cs00902b  1
2016 Poh JS, Browne DL, Ley SV. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry & Engineering. 1: 101-105. PMID 27398231 DOI: 10.1039/c5re00082c  1
2016 Poh JS, García-Ruiz C, Zúñiga A, Meroni F, Blakemore DC, Browne DL, Ley SV. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation. Organic & Biomolecular Chemistry. PMID 27225313 DOI: 10.1039/c6ob00970k  1
2016 Fitzpatrick DE, Battilocchio C, Ley SV. Enabling Technologies for the Future of Chemical Synthesis. Acs Central Science. 2: 131-8. PMID 27163040 DOI: 10.1021/acscentsci.6b00015  1
2016 Sutherell CL, Tallant C, Monteiro OP, Yapp C, Fuchs JE, Fedorov O, Siejka P, Müller S, Knapp S, Brenton JD, Brennan PE, Ley SV. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex. Journal of Medicinal Chemistry. PMID 27119626 DOI: 10.1021/acs.jmedchem.5b01997  1
2016 Battilocchio C, Feist F, Hafner A, Simon M, Tran DN, Allwood DM, Blakemore DC, Ley SV. Iterative reactions of transient boronic acids enable sequential C-C bond formation. Nature Chemistry. 8: 360-7. PMID 27001732 DOI: 10.1038/nchem.2439  1
2016 Lücke D, Dalton T, Ley SV, Wilson ZE. Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26844421 DOI: 10.1002/chem.201504457  0.32
2016 Brahma A, Musio B, Ismayilova U, Nikbin N, Kamptmann SB, Siegert P, Jeromin GE, Ley SV, Pohl M. An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins Synlett. 27: 262-266. DOI: 10.1055/s-0035-1560644  1
2015 Tran DN, Battilocchio C, Lou SB, Hawkins JM, Ley SV. Flow chemistry as a discovery tool to access sp-spcross-coupling reactionsdiazo compounds. Chemical Science. 6: 1120-1125. PMID 29560199 DOI: 10.1039/c4sc03072a  1
2015 Lau SH, Bourne SL, Martin B, Schenkel B, Penn G, Ley SV. Synthesis of a Precursor to Sacubitril Using Enabling Technologies. Organic Letters. 17: 5436-9. PMID 26509957 DOI: 10.1021/acs.orglett.5b02806  1
2015 Briggs ME, Slater AG, Lunt N, Jiang S, Little MA, Greenaway RL, Hasell T, Battilocchio C, Ley SV, Cooper AI. Dynamic flow synthesis of porous organic cages. Chemical Communications (Cambridge, England). PMID 26463103 DOI: 10.1039/c5cc07447a  1
2015 Schotten C, Plaza D, Manzini S, Nolan SP, Ley SV, Browne DL, Lapkin A. Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride. Acs Sustainable Chemistry & Engineering. 3: 1453-1459. PMID 26322250 DOI: 10.1021/acssuschemeng.5b00397  1
2015 Frost JR, Pearson CM, Snaddon TN, Booth RA, Turner RM, Gold J, Shaw DM, Gaunt MJ, Ley SV. Callipeltosides A, B and C: Total Syntheses and Structural Confirmation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 13261-77. PMID 26230615 DOI: 10.1002/chem.201501877  0.6
2015 De Lucia D, Lucio OM, Musio B, Bender A, Listing M, Dennhardt S, Koeberle A, Garscha U, Rizzo R, Manfredini S, Werz O, Ley SV. Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors. European Journal of Medicinal Chemistry. 101: 573-83. PMID 26197161 DOI: 10.1016/j.ejmech.2015.07.011  1
2015 Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ. Machine-Assisted Organic Synthesis. Angewandte Chemie (International Ed. in English). 54: 10122-36. PMID 26193360 DOI: 10.1002/anie.201501618  1
2015 Lau SH, Galván A, Merchant RR, Battilocchio C, Souto JA, Berry MB, Ley SV. Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439. Organic Letters. 17: 3218-21. PMID 26079282 DOI: 10.1021/acs.orglett.5b01307  1
2015 Poh JS, Tran DN, Battilocchio C, Hawkins JM, Ley SV. A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds. Angewandte Chemie (International Ed. in English). 54: 7920-3. PMID 26013774 DOI: 10.1002/anie.201501538  1
2015 Alves LC, Desiderá AL, de Oliveira KT, Newton S, Ley SV, Brocksom TJ. A practical deca-gram scale ring expansion of (R)-(-)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1. Organic & Biomolecular Chemistry. PMID 25997609 DOI: 10.1039/c5ob00525f  1
2015 Rouquet G, Moore DE, Spain M, Allwood DM, Battilocchio C, Blakemore DC, Fish PV, Jenkinson S, Jessiman AS, Ley SV, McMurray G, Storer RI. Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists. Acs Medicinal Chemistry Letters. 6: 329-33. PMID 25815155 DOI: 10.1021/ml500507v  1
2015 Kabeshov MA, Sliwiński É, Fitzpatrick DE, Musio B, Newby JA, Blaylock WD, Ley SV. Development of a web-based platform for studying lithiation reactions in silico. Chemical Communications (Cambridge, England). 51: 7172-5. PMID 25811168 DOI: 10.1039/c5cc00782h  0.48
2015 Souto JA, Stockman RA, Ley SV. Development of a flow method for the hydroboration/oxidation of olefins. Organic & Biomolecular Chemistry. 13: 3871-7. PMID 25714697 DOI: 10.1039/c5ob00170f  1
2015 Brzozowski M, O'Brien M, Ley SV, Polyzos A. Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor. Accounts of Chemical Research. 48: 349-62. PMID 25611216 DOI: 10.1021/ar500359m  1
2015 Roda NM, Tran DN, Battilocchio C, Labes R, Ingham RJ, Hawkins JM, Ley SV. Cyclopropanation using flow-generated diazo compounds. Organic & Biomolecular Chemistry. 13: 2550-4. PMID 25600950 DOI: 10.1039/c5ob00019j  1
2015 Ley SV, Fitzpatrick DE, Ingham RJ, Myers RM. Organic synthesis: march of the machines. Angewandte Chemie (International Ed. in English). 54: 3449-64. PMID 25586940 DOI: 10.1002/anie.201410744  1
2015 Wilson ZE, Fenner S, Ley SV. Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B. Angewandte Chemie (International Ed. in English). 54: 1284-8. PMID 25424526 DOI: 10.1002/anie.201410063  1
2015 Ingham RJ, Battilocchio C, Fitzpatrick DE, Sliwinski E, Hawkins JM, Ley SV. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences. Angewandte Chemie (International Ed. in English). 54: 144-8. PMID 25377747 DOI: 10.1002/anie.201409356  1
2015 Glöckner S, Tran DN, Ingham RJ, Fenner S, Wilson ZE, Battilocchio C, Ley SV. The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions. Organic & Biomolecular Chemistry. 13: 207-14. PMID 25370905 DOI: 10.1039/c4ob02105c  1
2015 Kamptmann SB, Ley SV. Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods Australian Journal of Chemistry. 68: 693-696. DOI: 10.1071/CH14530  1
2015 Hafner A, Ley SV. Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation Synlett. 26: 1470-1474. DOI: 10.1055/s-0034-1380679  0.48
2015 Tran DN, Battilocchio C, Lou SB, Hawkins JM, Ley SV. Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds Chemical Science. 6: 1120-1125. DOI: 10.1039/c4sc03072a  1
2015 Schotten C, Plaza D, Manzini S, Nolan SP, Ley SV, Browne DL, Lapkin A. Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride Acs Sustainable Chemistry and Engineering. 3: 1453-1459. DOI: 10.1021/acssuschemeng.5b00397  1
2015 Frost JR, Pearson CM, Snaddon TN, Booth RA, Turner RM, Gold J, Shaw DM, Gaunt MJ, Ley SV. Callipeltosides A, B and C: Total Syntheses and Structural Confirmation Chemistry - a European Journal. DOI: 10.1002/chem.201501877  1
2015 Deadman BJ, Browne DL, Baxendale IR, Ley SV. Back pressure regulation of slurry-forming reactions in continuous flow Chemical Engineering and Technology. 38: 259-264. DOI: 10.1002/ceat.201400445  1
2014 Myers RM, Fitzpatrick DE, Turner RM, Ley SV. Flow chemistry meets advanced functional materials. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 12348-66. PMID 25156609 DOI: 10.1002/chem.201402801  1
2014 Merchant RR, Allwood DM, Blakemore DC, Ley SV. Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles. The Journal of Organic Chemistry. 79: 8800-11. PMID 25148419 DOI: 10.1021/jo501624t  1
2014 Kabeshov MA, Musio B, Murray PR, Browne DL, Ley SV. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology. Organic Letters. 16: 4618-21. PMID 25147957 DOI: 10.1021/ol502201d  1
2014 Baumann M, Baxendale IR, Hornung CH, Ley SV, Rojo MV, Roper KA. Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations. Molecules (Basel, Switzerland). 19: 9736-59. PMID 25006783 DOI: 10.3390/molecules19079736  1
2014 Rouquet G, Blakemore DC, Ley SV. Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium. Chemical Communications (Cambridge, England). 50: 8908-11. PMID 24969811 DOI: 10.1039/c4cc03766a  1
2014 Allwood DM, Blakemore DC, Ley SV. Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion. Organic Letters. 16: 3064-7. PMID 24819872 DOI: 10.1021/ol5011714  1
2014 Ingham RJ, Battilocchio C, Hawkins JM, Ley SV. Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide. Beilstein Journal of Organic Chemistry. 10: 641-52. PMID 24778715 DOI: 10.3762/bjoc.10.56  1
2014 Hartwig J, Metternich JB, Nikbin N, Kirschning A, Ley SV. Continuous flow chemistry: a discovery tool for new chemical reactivity patterns. Organic & Biomolecular Chemistry. 12: 3611-5. PMID 24763674 DOI: 10.1039/c4ob00662c  1
2014 Newton S, Carter CF, Pearson CM, de C Alves L, Lange H, Thansandote P, Ley SV. Accelerating spirocyclic polyketide synthesis using flow chemistry. Angewandte Chemie (International Ed. in English). 53: 4915-20. PMID 24729438 DOI: 10.1002/anie.201402056  1
2014 Battilocchio C, Hawkins JM, Ley SV. Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide. Organic Letters. 16: 1060-3. PMID 24495110 DOI: 10.1021/ol403591c  1
2014 Newby JA, Huck L, Blaylock DW, Witt PM, Ley SV, Browne DL. Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 263-71. PMID 24339222 DOI: 10.1002/chem.201303736  1
2014 Allwood DM, Blakemore DC, Brown AD, Ley SV. Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids. The Journal of Organic Chemistry. 79: 328-38. PMID 24304206 DOI: 10.1021/jo402526z  1
2014 Knudsen KR, Ladlow M, Bandpey Z, Ley SV. Fully automated sequence-specific synthesis of α-peptides using flow chemistry Journal of Flow Chemistry. 4: 18-21. DOI: 10.1556/JFC-D-13-00033  1
2014 Guetzoyan L, Ingham RJ, Nikbin N, Rossignol J, Wolling M, Baumert M, Burgess-Brown NA, Strain-Damerell CM, Shrestha L, Brennan PE, Fedorov O, Knapp S, Ley SV. Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography Medchemcomm. 5: 540-546. DOI: 10.1039/c4md00007b  1
2014 Newby JA, Blaylock DW, Witt PM, Turner RM, Heider PL, Harji BH, Browne DL, Ley SV. Reconfiguration of a continuous flow platform for extended operation: Application to a cryogenic fluorine-directed ortho-lithiation reaction Organic Process Research and Development. 18: 1221-1228. DOI: 10.1021/op500221s  1
2014 Newby JA, Blaylock DW, Witt PM, Pastre JC, Zacharova MK, Ley SV, Browne DL. Design and application of a low-temperature continuous flow chemistry platform Organic Process Research and Development. 18: 1211-1220. DOI: 10.1021/op500213j  1
2014 Ouchi T, Battilocchio C, Hawkins JM, Ley SV. Process intensification for the continuous flow hydrogenation of ethyl nicotinate Organic Process Research and Development. 18: 1560-1566. DOI: 10.1021/op500208j  1
2014 Witt PM, Somasi S, Khan I, Blaylock DW, Newby JA, Ley SV. Modeling mesoscale reactors for the production of fine chemicals Chemical Engineering Journal. DOI: 10.1016/j.cej.2014.12.030  0.48
2014 Battilocchio C, Bhawal BN, Chorghade R, Deadman BJ, Hawkins JM, Ley SV. Flow-based, cerium oxide enhanced, low-level palladium sonogashira and heck coupling reactions by perovskite catalysts Israel Journal of Chemistry. 54: 371-380. DOI: 10.1002/ijch.201300049  1
2014 Gross U, Koos P, O'Brien M, Polyzos A, Ley SV. A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors European Journal of Organic Chemistry. 2014: 6418-6430. DOI: 10.1002/ejoc.201402804  1
2013 Battilocchio C, Guetzoyan L, Cervetto C, Di Cesare Mannelli L, Frattaroli D, Baxendale IR, Maura G, Rossi A, Sautebin L, Biava M, Ghelardini C, Marcoli M, Ley SV. Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release. Acs Medicinal Chemistry Letters. 4: 704-9. PMID 24900736 DOI: 10.1021/ml400079h  1
2013 Watts CA, Richards FM, Bender A, Bond PJ, Korb O, Kern O, Riddick M, Owen P, Myers RM, Raff J, Gergely F, Jodrell DI, Ley SV. Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes. Chemistry & Biology. 20: 1399-410. PMID 24210220 DOI: 10.1016/j.chembiol.2013.09.012  1
2013 Chorghade R, Battilocchio C, Hawkins JM, Ley SV. Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst. Organic Letters. 15: 5698-701. PMID 24161124 DOI: 10.1021/ol4027107  1
2013 Roper KA, Berry MB, Ley SV. The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow. Beilstein Journal of Organic Chemistry. 9: 1781-90. PMID 24062843 DOI: 10.3762/bjoc.9.207  1
2013 Pastre JC, Browne DL, Ley SV. Flow chemistry syntheses of natural products. Chemical Society Reviews. 42: 8849-69. PMID 23999700 DOI: 10.1039/c3cs60246j  1
2013 Morley AD, Pugliese A, Birchall K, Bower J, Brennan P, Brown N, Chapman T, Drysdale M, Gilbert IH, Hoelder S, Jordan A, Ley SV, Merritt A, Miller D, Swarbrick ME, et al. Fragment-based hit identification: thinking in 3D. Drug Discovery Today. 18: 1221-7. PMID 23906694 DOI: 10.1016/j.drudis.2013.07.011  1
2013 Ley SV, Ingham RJ, O'Brien M, Browne DL. Camera-enabled techniques for organic synthesis. Beilstein Journal of Organic Chemistry. 9: 1051-72. PMID 23766820 DOI: 10.3762/bjoc.9.118  1
2013 Baxendale IR, Cheung S, Kitching MO, Ley SV, Shearman JW. The synthesis of neurotensin antagonist SR 48692 for prostate cancer research. Bioorganic & Medicinal Chemistry. 21: 4378-87. PMID 23721919 DOI: 10.1016/j.bmc.2013.04.075  1
2013 Battilocchio C, Deadman BJ, Nikbin N, Kitching MO, Baxendale IR, Ley SV. A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 7917-30. PMID 23592596 DOI: 10.1002/chem.201300696  1
2013 Battilocchio C, Hawkins JM, Ley SV. A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia. Organic Letters. 15: 2278-81. PMID 23590578 DOI: 10.1021/ol400856g  1
2013 Deadman BJ, Hopkin MD, Baxendale IR, Ley SV. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib. Organic & Biomolecular Chemistry. 11: 1766-800. PMID 23247657 DOI: 10.1039/c2ob27003j  1
2013 Hopkin MD, Baxendale IR, Ley SV. An expeditious synthesis of imatinib and analogues utilising flow chemistry methods. Organic & Biomolecular Chemistry. 11: 1822-39. PMID 23247615 DOI: 10.1039/c2ob27002a  1
2013 Baxendale IR, Hornung C, Ley SV, De Mata Muñoz Molina J, Wikström A. Flow microwave technology and microreactors in synthesis Australian Journal of Chemistry. 66: 131-144. DOI: 10.1071/CH12365  1
2013 Nakayama K, Browne DL, Baxendale IR, Ley SV. Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor Synlett. 24: 1298-1302. DOI: 10.1055/s-0033-1338455  1
2013 Fernández A, Levine ZG, Baumann M, Sulzer-Mossé S, Sparr C, Schläger S, Metzger A, Baxendale IR, Ley SV. Synthesis of (-)-hennoxazole A: Integrating batch and flow chemistry methods Synlett. 24: 514-518. DOI: 10.1055/s-0032-1318109  1
2013 Kraus H, Français A, O'Brien M, Frost J, Diéguez-Vázquez A, Polara A, Baricordi N, Horan R, Hsu DS, Tsunoda T, Ley SV. Synthesis of spongistatin 2 employing a new route to the EF fragment Chemical Science. 4: 1989-1994. DOI: 10.1039/c3sc50304f  1
2013 Deadman BJ, Battilocchio C, Sliwinski E, Ley SV. A prototype device for evaporation in batch and flow chemical processes Green Chemistry. 15: 2050-2055. DOI: 10.1039/c3gc40967h  1
2013 Guetzoyan L, Nikbin N, Baxendale IR, Ley SV. Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography Chemical Science. 4: 764-769. DOI: 10.1039/c2sc21850j  1
2013 Murray PRD, Browne DL, Pastre JC, Butters C, Guthrie D, Ley SV. Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen Organic Process Research and Development. 17: 1192-1208. DOI: 10.1021/op4001548  1
2013 Pastre JC, Browne DL, O'Brien M, Ley SV. Scaling up of continuous flow processes with gases using a tube-in-tube reactor: Inline titrations and fanetizole synthesis with ammonia Organic Process Research and Development. 17: 1183-1191. DOI: 10.1021/op400152r  1
2013 Browne DL, Harji BH, Ley SV. Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes Chemical Engineering and Technology. 36: 959-967. DOI: 10.1002/ceat.201200581  1
2013 Bourne SL, O'Brien M, Kasinathan S, Koos P, Tolstoy P, Hu DX, Bates RW, Martin B, Schenkel B, Ley SV. Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes Chemcatchem. 5: 159-172. DOI: 10.1002/cctc.201200778  1
2013 Bourne SL, Ley SV. A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidation Advanced Synthesis and Catalysis. 355: 1905-1910. DOI: 10.1002/adsc.201300278  1
2012 Beale TM, Allwood DM, Bender A, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM, Shearman JW, Temple J, Unger J, Watts CA, Xian J. A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles. Acs Medicinal Chemistry Letters. 3: 177-81. PMID 24900453 DOI: 10.1021/ml200149g  1
2012 Tran G, Meier R, Harris L, Browne DL, Ley SV. Synthesis and use of a trifluoromethylated azomethine ylide precursor. The Journal of Organic Chemistry. 77: 11071-8. PMID 23176732 DOI: 10.1021/jo302052m  1
2012 Tolstoy P, Lee SX, Sparr C, Ley SV. Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides. Organic Letters. 14: 4810-3. PMID 22946713 DOI: 10.1021/ol302119j  1
2012 Frost JR, Pearson CM, Snaddon TN, Booth RA, Ley SV. Convergent total syntheses of callipeltosides A, B, and C. Angewandte Chemie (International Ed. in English). 51: 9366-71. PMID 22915468 DOI: 10.1002/anie.201204868  1
2012 Hu DX, O'Brien M, Ley SV. Continuous multiple liquid-liquid separation: diazotization of amino acids in flow. Organic Letters. 14: 4246-9. PMID 22866828 DOI: 10.1021/ol301930h  1
2012 O'Brien M, Koos P, Browne DL, Ley SV. A prototype continuous-flow liquid-liquid extraction system using open-source technology. Organic & Biomolecular Chemistry. 10: 7031-6. PMID 22858870 DOI: 10.1039/c2ob25912e  1
2012 Browne DL, Wright S, Deadman BJ, Dunnage S, Baxendale IR, Turner RM, Ley SV. Continuous flow reaction monitoring using an on-line miniature mass spectrometer. Rapid Communications in Mass Spectrometry : Rcm. 26: 1999-2010. PMID 22847699 DOI: 10.1002/rcm.6312  1
2012 Ingham RJ, Riva E, Nikbin N, Baxendale IR, Ley SV. A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the Imatinib base. Organic Letters. 14: 3920-3. PMID 22812401 DOI: 10.1021/ol301673q  1
2012 Ley SV. On being green: can flow chemistry help? Chemical Record (New York, N.Y.). 12: 378-90. PMID 22711555 DOI: 10.1002/tcr.201100041  1
2012 Hu DX, Grice P, Ley SV. Rotamers or diastereomers? An overlooked NMR solution. The Journal of Organic Chemistry. 77: 5198-202. PMID 22594462 DOI: 10.1021/jo300734r  1
2012 Cranwell PB, O'Brien M, Browne DL, Koos P, Polyzos A, Peña-López M, Ley SV. Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration. Organic & Biomolecular Chemistry. 10: 5774-9. PMID 22532036 DOI: 10.1039/c2ob25407g  1
2012 Beale TM, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM. Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1. Bioorganic & Medicinal Chemistry. 20: 1749-59. PMID 22304851 DOI: 10.1016/j.bmc.2012.01.010  1
2012 Wegner J, Ley SV, Kirschning A, Hansen AL, Garcia JM, Baxendale IR. A total synthesis of millingtonine A. Organic Letters. 14: 696-9. PMID 22260734 DOI: 10.1021/ol203158p  1
2012 Petersen TP, Polyzos A, O'Brien M, Ulven T, Baxendale IR, Ley SV. The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: using Teflon AF-2400 to effect gas/liquid contact. Chemsuschem. 5: 274-7. PMID 21948655 DOI: 10.1002/cssc.201100339  1
2012 Koos P, Browne DL, Ley SV. Continuous stream processing: A prototype magnetic field induced flow mixer Green Processing and Synthesis. 1: 11-18. DOI: 10.1515/greenps-2011-0501  1
2012 Browne D, O'Brien M, Koos P, Cranwell PB, Polyzos A, Ley SV. Continuous-flow processing of gaseous ammonia using a Teflon AF-2400 tube-in-tube reactor: Synthesis of thioureas and in-line titrations Synlett. 23: 1402-1406. DOI: 10.1055/s-0031-1290963  1
2012 Battilocchio C, Baumann M, Baxendale IR, Biava M, Kitching MO, Ley SV, Martin RE, Ohnmacht SA, Tappin NDC. Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands Synthesis. 44: 635-647. DOI: 10.1055/s-0031-1289676  1
2012 Battilocchio C, Baxendale IR, Biava M, Kitching MO, Ley SV. A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid Organic Process Research and Development. 16: 798-810. DOI: 10.1021/op300084z  1
2012 Brodmann T, Koos P, Metzger A, Knochel P, Ley SV. Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring Organic Process Research and Development. 16: 1102-1113. DOI: 10.1021/op200275d  1
2012 Hu DX, Bielitza M, Koos P, Ley SV. A total synthesis of the ammonium ionophore, (-)-enniatin B Tetrahedron Letters. 53: 4077-4079. DOI: 10.1016/j.tetlet.2012.05.110  1
2012 Newton S, Ley SV, Arcé EC, Grainger DM. Asymmetric homogeneous hydrogenation in flow using a tube-in-tube reactor Advanced Synthesis and Catalysis. 354: 1805-1812. DOI: 10.1002/adsc.201200073  1
2012 Myers RM, Roper KA, Baxendale IR, Ley SV. The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds Modern Tools For the Synthesis of Complex Bioactive Molecules. 359-393. DOI: 10.1002/9781118342886.ch11  1
2012 Hopkin MD, Baxendale IR, Ley SV. The Lab of the Future. the importance of remote monitoring and control Chimica Oggi/Chemistry Today. 30: 24-26.  1
2011 Roper KA, Lange H, Polyzos A, Berry MB, Baxendale IR, Ley SV. The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors. Beilstein Journal of Organic Chemistry. 7: 1648-55. PMID 22238543 DOI: 10.3762/bjoc.7.194  1
2011 Koos P, Gross U, Polyzos A, O'Brien M, Baxendale I, Ley SV. Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration. Organic & Biomolecular Chemistry. 9: 6903-8. PMID 21874192 DOI: 10.1039/c1ob06017a  1
2011 Ley SV. Concepts and strategies for oligosaccharide synthesis. Foreword. Topics in Current Chemistry. 301: ix. PMID 21755617  1
2011 Oelke AJ, France DJ, Hofmann T, Wuitschik G, Ley SV. Piperazic acid-containing natural products: isolation, biological relevance and total synthesis. Natural Product Reports. 28: 1445-71. PMID 21731941 DOI: 10.1039/c1np00041a  1
2011 Baumann M, Baxendale IR, Ley SV, Nikbin N. An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals. Beilstein Journal of Organic Chemistry. 7: 442-95. PMID 21647262 DOI: 10.3762/bjoc.7.57  1
2011 Browne DL, Baumann M, Harji BH, Baxendale IR, Ley SV. A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures. Organic Letters. 13: 3312-5. PMID 21615126 DOI: 10.1021/ol2010006  1
2011 Merritt AT, Pouwer RH, Williams DJ, Williams CM, Ley SV. The clerodane ring system: investigating the viability of a direct Diels-Alder approach. Organic & Biomolecular Chemistry. 9: 4745-7. PMID 21597622 DOI: 10.1039/c1ob05422h  1
2011 Lupo G, Gestri G, O'Brien M, Denton RM, Chandraratna RA, Ley SV, Harris WA, Wilson SW. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 108: 8698-703. PMID 21555593 DOI: 10.1073/pnas.1103802108  1
2011 Baumann M, Baxendale IR, Kuratli C, Ley SV, Martin RE, Schneider J. Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods. Acs Combinatorial Science. 13: 405-13. PMID 21528880 DOI: 10.1021/co2000357  1
2011 Oelke AJ, Antonietti F, Bertone L, Cranwell PB, France DJ, Goss RJ, Hofmann T, Knauer S, Moss SJ, Skelton PC, Turner RM, Wuitschik G, Ley SV. Total synthesis of chloptosin: a dimeric cyclohexapeptide. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 4183-94. PMID 21412862 DOI: 10.1002/chem.201003216  1
2011 Carter CF, Lange H, Sakai D, Baxendale IR, Ley SV. Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 3398-405. PMID 21344524 DOI: 10.1002/chem.201003148  1
2011 Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. The Journal of Biological Chemistry. 286: 16163-73. PMID 21325280 DOI: 10.1074/jbc.M110.171082  1
2011 Smith CJ, Nikbin N, Ley SV, Lange H, Baxendale IR. A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles. Organic & Biomolecular Chemistry. 9: 1938-47. PMID 21283874 DOI: 10.1039/c0ob00815j  1
2011 Smith CJ, Smith CD, Nikbin N, Ley SV, Baxendale IR. Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent. Organic & Biomolecular Chemistry. 9: 1927-37. PMID 21283873 DOI: 10.1039/c0ob00813c  1
2011 Polyzos A, O'Brien M, Petersen TP, Baxendale IR, Ley SV. The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor. Angewandte Chemie (International Ed. in English). 50: 1190-3. PMID 21268224 DOI: 10.1002/anie.201006618  1
2011 Français A, Leyva-Pérez A, Etxebarria-Jardi G, Peña J, Ley SV. Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 329-43. PMID 21207629 DOI: 10.1002/chem.201002380  1
2011 Martin LJ, Marzinzik AL, Ley SV, Baxendale IR. Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor. Organic Letters. 13: 320-3. PMID 21162548 DOI: 10.1021/ol1027927  1
2011 Hodgkinson JT, Galloway WR, Saraf S, Baxendale IR, Ley SV, Ladlow M, Welch M, Spring DR. Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues. Organic & Biomolecular Chemistry. 9: 57-61. PMID 20967360 DOI: 10.1039/c0ob00652a  1
2011 Baumann M, Baxendale IR, Ley SV. The flow synthesis of heterocycles for natural product and medicinal chemistry applications. Molecular Diversity. 15: 613-30. PMID 20960230 DOI: 10.1007/s11030-010-9282-1  1
2011 Shearman JW, Myers RM, Brenton JD, Ley SV. Total syntheses of subereamollines A and B. Organic & Biomolecular Chemistry. 9: 62-5. PMID 20953439 DOI: 10.1039/c0ob00636j  1
2011 Kasinathan S, Bourne SL, Tolstoy P, Koos P, Obrien M, Bates RW, Baxendale IR, Ley SV. Syngas-mediated C-C bond formation in flow: Selective rhodium-catalysed hydroformylation of styrenes Synlett. 2648-2651. DOI: 10.1055/s-0031-1289292  1
2011 Bourne SL, Koos P, Obrien M, Martin B, Schenkel B, Baxendale IR, Ley SV. The continuous-flow synthesis of styrenes using ethylene in a palladium-catalysed heck cross-coupling reaction Synlett. 2643-2647. DOI: 10.1055/s-0031-1289291  1
2011 Baumann M, Baxendale IR, Brasholz M, Hayward JJ, Ley SV, Nikbin N. An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole Synlett. 1375-1380. DOI: 10.1055/s-0030-1260573  1
2011 O'Brien M, Denton R, Ley SV. Lesser-known enabling technologies for organic synthesis Synthesis. 1157-1192. DOI: 10.1055/s-0030-1259979  1
2011 Lange H, Capener MJ, Jones AX, Smith CJ, Nikbin N, Baxendale IR, Ley SV. Oxidation reactions in segmented and continuous flow chemical processing using an N -(tert -Butyl)phenylsulfinimidoyl chloride monolith Synlett. 869-873. DOI: 10.1055/s-0030-1259923  1
2011 O'Brien M, Taylor N, Polyzos A, Baxendale IR, Ley SV. Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas-liquid contact at elevated pressure Chemical Science. 2: 1250-1257. DOI: 10.1039/c1sc00055a  1
2011 Lange H, Carter CF, Hopkin MD, Burke A, Goode JG, Baxendalea IR, Ley SV. A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing Chemical Science. 2: 765-769. DOI: 10.1039/c0sc00603c  1
2011 Browne DL, Deadman BJ, Ashe R, Baxendale IR, Ley SV. Continuous flow processing of slurries: Evaluation of an agitated cell reactor Organic Process Research and Development. 15: 693-697. DOI: 10.1021/op2000223  1
2011 Browne DL, Baxendale IR, Ley SV. Piecing together the puzzle: Understanding a mild, metal free reduction method for the large scale synthesis of hydrazines Tetrahedron. 67: 10296-10303. DOI: 10.1016/j.tet.2011.09.146  1
2011 Ley SV. Topics in Current Chemistry: Foreword Topics in Current Chemistry. 301: ix. DOI: 10.1007/978-3-642-20914-7  1
2011 Hopkin MD, Baxendale IR, Ley SV. The lab of the future: The importance of remote monitoring and control Chimica Oggi. 29: 28-33.  1
2010 Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, et al. Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 107: 20483-8. PMID 21059958 DOI: 10.1073/pnas.1008255107  1
2010 Malet-Sanz L, Madrzak J, Ley SV, Baxendale IR. Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor. Organic & Biomolecular Chemistry. 8: 5324-32. PMID 20877783 DOI: 10.1039/c0ob00450b  1
2010 Qian Z, Baxendale IR, Ley SV. A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 12342-8. PMID 20859972 DOI: 10.1002/chem.201002147  1
2010 Sedelmeier J, Ley SV, Baxendale IR, Baumann M. KMnO(4)-Mediated oxidation as a continuous flow process. Organic Letters. 12: 3618-21. PMID 20704404 DOI: 10.1021/ol101345z  1
2010 Oelke AJ, France DJ, Hofmann T, Wuitschik G, Ley SV. Total synthesis of chloptosin. Angewandte Chemie (International Ed. in English). 49: 6139-42. PMID 20645377 DOI: 10.1002/anie.201002880  1
2010 Venturoni F, Nikbin N, Ley SV, Baxendale IR. The application of flow microreactors to the preparation of a family of casein kinase I inhibitors. Organic & Biomolecular Chemistry. 8: 1798-806. PMID 20449482 DOI: 10.1039/b925327k  1
2010 Hopkin MD, Baxendale IR, Ley SV. A flow-based synthesis of imatinib: the API of Gleevec. Chemical Communications (Cambridge, England). 46: 2450-2. PMID 20309467 DOI: 10.1039/c001550d  1
2010 Carter CF, Baxendale IR, Pavey JB, Ley SV. The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors. Organic & Biomolecular Chemistry. 8: 1588-95. PMID 20237669 DOI: 10.1039/b924309g  1
2010 O'Brien M, Baxendale IR, Ley SV. Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas-liquid contact. Organic Letters. 12: 1596-8. PMID 20218640 DOI: 10.1021/ol100322t  1
2010 Francais A, Leyva A, Etxebarria-Jardi G, Ley SV. Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids. Organic Letters. 12: 340-3. PMID 20014782 DOI: 10.1021/ol902676t  1
2010 Baxendale IR, Schou SC, Sedelmeier J, Ley SV. Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 89-94. PMID 19938024 DOI: 10.1002/chem.200902906  1
2010 Baumann M, Baxendale IR, Kirschning A, Ley SV, Wegner J. Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor Heterocycles. 82: 1297-1316. DOI: 10.3987/COM-10-S(E)77  1
2010 Tozzi F, Ley SV, Kitching MO, Baxendale IR. Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes Synlett. 1919-1922. DOI: 10.1055/s-0030-1258486  1
2010 Qian Z, Baxendale IR, Ley SV. A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist Synlett. 505-508. DOI: 10.1055/s-0029-1219358  1
2010 Baumann M, Baxendale IR, Ley SV. Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor Synlett. 749-752. DOI: 10.1055/s-0029-1219344  1
2010 Beale TM, Myers RM, Shearman JW, Charnock-Jones DS, Brenton JD, Gergely FV, Ley SV. Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4 Medchemcomm. 1: 202-208. DOI: 10.1039/c0md00095g  1
2010 Carter CF, Lange H, Ley SV, Baxendale IR, Wittkamp B, Goode JG, Gaunt NL. ReactIR flow cell: A new analytical tool for continuous flow chemical processing Organic Process Research and Development. 14: 393-404. DOI: 10.1021/op900305v  1
2010 Hornung CH, Hallmark B, Baumann M, Baxendale IR, Ley SV, Hester P, Clayton P, MacKley MR. Multiple microcapillary reactor for organic synthesis Industrial and Engineering Chemistry Research. 49: 4576-4582. DOI: 10.1021/ie901674h  1
2010 Shearman JW, Myers RM, Beale TM, Brenton JD, Ley SV. Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 Tetrahedron Letters. 51: 4812-4814. DOI: 10.1016/j.tetlet.2010.07.016  1
2010 Ley SV. The changing face of organic synthesis Tetrahedron. 66: 6270-6292. DOI: 10.1016/j.tet.2010.05.049  1
2010 Catalán-Muñoz S, Müller CA, Ley SV. An asymmetric tandem conjugative addition-intramolecular cyclisation process to provide functionalised 3,6-dihydropyrans and 4,5- epoxytetrahydropyrans European Journal of Organic Chemistry. 183-190. DOI: 10.1002/ejoc.200901145  1
2010 Hornung C, Hallmark B, Mackley MR, Baxendale IR, Ley SV. A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation Advanced Synthesis and Catalysis. 352: 1736-1745. DOI: 10.1002/adsc.201000139  1
2009 Carter CF, Baxendale IR, O'Brien M, Pavey JB, Ley SV. Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates. Organic & Biomolecular Chemistry. 7: 4594-7. PMID 19865693 DOI: 10.1039/b917289k  1
2009 Palmieri A, Ley SV, Polyzos A, Ladlow M, Baxendale IR. Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters. Beilstein Journal of Organic Chemistry. 5: 23. PMID 19590738 DOI: 10.3762/bjoc.5.23  1
2009 Myers RM, Shearman JW, Kitching MO, Ramos-Montoya A, Neal DE, Ley SV. Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors. Acs Chemical Biology. 4: 503-25. PMID 19462983 DOI: 10.1021/cb900038e  1
2009 Baxendale IR, Ley SV, Mansfield AC, Smith CD. Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles. Angewandte Chemie (International Ed. in English). 48: 4017-21. PMID 19388020 DOI: 10.1002/anie.200900970  1
2009 Ley SV, Tackett MN, Maddess ML, Anderson JC, Brennan PE, Cappi MW, Heer JP, Helgen C, Kori M, Kouklovsky C, Marsden SP, Norman J, Osborn DP, Palomero MA, Pavey JB, et al. Total synthesis of rapamycin. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 2874-914. PMID 19204960 DOI: 10.1002/chem.200801656  1
2009 Evans AC, Longbottom DA, Matsuoka M, Davies JE, Turner R, Franckevicius V, Ley SV. Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis. Organic & Biomolecular Chemistry. 7: 747-60. PMID 19194591 DOI: 10.1039/b813494d  1
2009 Boyer A, Veitch GE, Beckmann E, Ley SV. Second-generation synthesis of azadirachtin: a concise preparation of the propargylic mesylate fragment. Angewandte Chemie (International Ed. in English). 48: 1317-20. PMID 19140148 DOI: 10.1002/anie.200805395  1
2009 Enríquez-García A, Ley SV. Total synthesis of the potent antifungal agents bengazole C and E Collection of Czechoslovak Chemical Communications. 74: 887-900. DOI: 10.1135/cccc2009016  1
2009 Webb D, Van Den Heuvel A, Kögl M, Ley SV. Enantioselective synthesis of the lyngbouilloside macrolactone core Synlett. 2320-2324. DOI: 10.1055/s-0029-1217707  1
2009 Baxendale IR, Buckle CD, Ley SV, Tamborini L. A base-catalysed one-pot three-component coupling reaction leading to nitrosubstituted pyrroles Synthesis. 1485-1493. DOI: 10.1055/s-0028-1087991  1
2009 Sedelmeier J, Ley SV, Baxendale IR. An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process Green Chemistry. 11: 683-685. DOI: 10.1039/b821752a  1
2009 Palmieri A, Ley SV, Hammond K, Polyzos A, Baxendale IR. A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement Tetrahedron Letters. 50: 3287-3289. DOI: 10.1016/j.tetlet.2009.02.059  1
2009 Baumann M, Baxendale IR, Martin LJ, Ley SV. Development of fluorination methods using continuous-flow microreactors Tetrahedron. 65: 6611-6625. DOI: 10.1016/j.tet.2009.05.083  1
2009 Sedelmeier J, Ley SV, Lange H, Baxendale IR. Pd-EnCat™ TPP30 as a catalyst for the generation of highly functionalized aryl- and alkenyl-substituted acetylenes via microwave-assisted sonogashira type reactions European Journal of Organic Chemistry. 4412-4420. DOI: 10.1002/ejoc.200900344  1
2009 Diéguez-Vázquez A, Tzschucke CC, Creeente-Campo J, McGrath S, Ley SV. AuCl3-catalyzed hydroalkoxylatlon of conjugated alkynoates: Synthesis of five- and six-membered cyclic acetals European Journal of Organic Chemistry. 1698-1706. DOI: 10.1002/ejoc.200801221  1
2009 Thomas AW, Ley SV. Copper-Catalyzed Arylations of Amines and Alcohols with Boron-Based Arylating Reagents Modern Arylation Methods. 121-154. DOI: 10.1002/9783527627325.ch4  1
2009 Baxendale IR, Lee AL, Ley SV. Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents Microwave Assisted Organic Synthesis. 133-176. DOI: 10.1002/9781444305548.ch6  1
2009 Cranwell PB, Ley SV. Total synthesis of (-)-spirangien a and the corresponding methyl ester Chemtracts. 22: 173-181.  1
2008 Veitch GE, Boyer A, Ley SV. The azadirachtin story. Angewandte Chemie (International Ed. in English). 47: 9402-29. PMID 19031481 DOI: 10.1002/anie.200802675  1
2008 Milroy LG, Zinzalla G, Loiseau F, Qian Z, Prencipe G, Pepper C, Fegan C, Ley SV. Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia. Chemmedchem. 3: 1922-35. PMID 19025736 DOI: 10.1002/cmdc.200800265  1
2008 Ley SV, Abad-Somovilla A, Anderson JC, Ayats C, Bänteli R, Beckmann E, Boyer A, Brasca MG, Brice A, Broughton HB, Burke BJ, Cleator E, Craig D, Denholm AA, Denton RM, et al. The synthesis of azadirachtin: a potent insect antifeedant. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 10683-704. PMID 18821532 DOI: 10.1002/chem.200801103  1
2008 Bridgwood KL, Tzschucke CC, O'Brien M, Wittrock S, Goodman JM, Davies JE, Logan AW, Hüttl MR, Ley SV. Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines. Organic Letters. 10: 4537-40. PMID 18816124 DOI: 10.1021/ol8018242  1
2008 Baxendale IR, Ley SV, Smith CD, Tamborini L, Voica AF. A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor. Journal of Combinatorial Chemistry. 10: 851-7. PMID 18783277 DOI: 10.1021/cc800070a  1
2008 Bridgwood KL, Veitch GE, Ley SV. Magnesium nitride as a convenient source of ammonia: preparation of dihydropyridines. Organic Letters. 10: 3627-9. PMID 18642824 DOI: 10.1021/ol801399w  1
2008 Veitch GE, Bridgwood KL, Ley SV. Magnesium nitride as a convenient source of ammonia: preparation of primary amides. Organic Letters. 10: 3623-5. PMID 18642822 DOI: 10.1021/ol801398z  1
2008 Wascholowski V, Knudsen KR, Mitchell CE, Ley SV. A general organocatalytic enantioselective malonate addition to alpha,beta-unsaturated enones. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 6155-65. PMID 18512863 DOI: 10.1002/chem.200800673  1
2008 Baumann M, Baxendale IR, Ley SV, Nikbin N, Smith CD. Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions. Organic & Biomolecular Chemistry. 6: 1587-93. PMID 18421390 DOI: 10.1039/b801634h  1
2008 Baumann M, Baxendale IR, Ley SV, Nikbin N, Smith CD, Tierney JP. A modular flow reactor for performing Curtius rearrangements as a continuous flow process. Organic & Biomolecular Chemistry. 6: 1577-86. PMID 18421389 DOI: 10.1039/b801631n  1
2008 Maddess ML, Tackett MN, Ley SV. Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 66: 13, 15-186. PMID 18416305 DOI: 10.1007/978-3-7643-8595-8-2  1
2008 O'Brien M, Diéguez-Vázquez A, Hsu DS, Kraus H, Sumino Y, Ley SV. Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1. Organic & Biomolecular Chemistry. 6: 1159-64. PMID 18362951 DOI: 10.1039/b719569a  1
2008 Raja R, Thomas JM, Greenhill-Hooper M, Ley SV, Almeida Paz FA. Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 2340-8. PMID 18228543 DOI: 10.1002/chem.200701679  1
2008 Veitch GE, Pinto A, Boyer A, Beckmann E, Anderson JC, Ley SV. Synthesis of natural products from the Indian neem tree Azadirachta indica. Organic Letters. 10: 569-72. PMID 18193879 DOI: 10.1021/ol7027898  1
2008 Diéguez-Vázquez A, Tzschucke CC, Lam WY, Ley SV. PtCl4-catalyzed domino synthesis of fused bicyclic acetals. Angewandte Chemie (International Ed. in English). 47: 209-12. PMID 18061909 DOI: 10.1002/anie.200704595  1
2008 Baumann M, Baxendale IR, Ley SV. The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor Synlett. 2111-2114. DOI: 10.1055/s-2008-1078026  1
2008 Tzschucke CC, Pradidphol N, Diéguez-Vázquez A, Kongkathip B, Kongkathip N, Ley SV. FeCl3-catalysed cleavage of 1,2-butanediacetal protected diols Synlett. 1293-1296. DOI: 10.1055/s-2008-1072752  1
2008 Hopkin MD, Baxendale IR, Ley SV. A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process Synthesis. 1688-1702. DOI: 10.1055/s-2008-1067048  1
2008 Wascholowski V, Hansen HM, Longbottom DA, Ley SV. A general organocatalytic enantioselective nitrocyclopropanation reaction Synthesis. 1269-1275. DOI: 10.1055/s-2008-1042944  1
2008 Veitch GE, Bridgwood KL, Rands-Trevor K, Ley SV. Magnesium nitride as a convenient source of ammonia: Preparation of pyrroles Synlett. 2597-2600. DOI: 10.1055/s-0028-1083504  1
2008 Leyva A, Blum FE, Ley SV. A new synthesis of (-)-epipyriculol: a phytotoxic metabolite Tetrahedron. 64: 4711-4717. DOI: 10.1016/j.tet.2008.01.115  1
2008 Leyva A, Blum FE, Hewitt PR, Ley SV. Functionalised butanediacetal-protected 1,2-diols as suitable partners for Pd-catalysed cross-coupling reactions Tetrahedron. 64: 2348-2358. DOI: 10.1016/j.tet.2008.01.010  1
2008 Fukuyama T, Rahman MT, Ryu I, Baxendale IR, Hayward JJ, Lanners S, Ley SV, Smith CD, Ahmed-Omer B, Wirth T, Hessel V, Löb P, Löwe H, Koch K, Rutjes FPJT, et al. Organic Chemistry in Microreactors Microreactors in Organic Synthesis and Catalysis. 59-209. DOI: 10.1002/9783527622856.ch4  1
2008 Aureggi V, Franckevičius V, Kitching MO, Ley SV, Longbottom DA, Oelke AJ, Sedelmeier G. (S)-5-pyrrolidin-2-yl-1H-tetrazole Organic Syntheses. 85: 72-87.  1
2008 Carter CF, Ley SV. Methyliminodiacetic acid (MIDA) protected boronates: A new strategy for organic synthesis Chemtracts. 21: 457-465.  1
2008 Ley SV. New tools for molecule makers: Emerging technologies Vdi Berichte. 5-7.  1
2008 Longbottom DA, Franckevičius V, Kumarn S, Oelke AJ, Wascholowski V, Ley SV. Practical organocatalysis with (S)- and (r)-5-pyrrolidin-2-yl-1H-tetrazoles Aldrichimica Acta. 41: 3-11.  1
2007 Baxendale IR, Hayward JJ, Ley SV. Microwave reactions under continuous flow conditions. Combinatorial Chemistry & High Throughput Screening. 10: 802-36. PMID 18288946 DOI: 10.2174/138620707783220374  1
2007 Kumarn S, Oelke AJ, Shaw DM, Longbottom DA, Ley SV. A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines. Organic & Biomolecular Chemistry. 5: 2678-89. PMID 18019543  1
2007 Smith CJ, Iglesias-Sigüenza FJ, Baxendale IR, Ley SV. Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines. Organic & Biomolecular Chemistry. 5: 2758-61. PMID 17700841 DOI: 10.1039/b709043a  0.56
2007 Veitch GE, Beckmann E, Burke BJ, Boyer A, Maslen SL, Ley SV. Synthesis of azadirachtin: a long but successful journey. Angewandte Chemie (International Ed. in English). 46: 7629-32. PMID 17665403 DOI: 10.1002/anie.200703027  1
2007 Veitch GE, Beckmann E, Burke BJ, Boyer A, Ayats C, Ley SV. A relay route for the synthesis of azadirachtin. Angewandte Chemie (International Ed. in English). 46: 7633-5. PMID 17665383 DOI: 10.1002/anie.200703028  1
2007 Smith CD, Baxendale IR, Tranmer GK, Baumann M, Smith SC, Lewthwaite RA, Ley SV. Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor. Organic & Biomolecular Chemistry. 5: 1562-8. PMID 17571185 DOI: 10.1039/b703033a  1
2007 Smith CD, Baxendale IR, Lanners S, Hayward JJ, Smith SC, Ley SV. [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor. Organic & Biomolecular Chemistry. 5: 1559-61. PMID 17571184 DOI: 10.1039/b702995k  1
2007 Andrews SP, Ball M, Wierschem F, Cleator E, Oliver S, Högenauer K, Simic O, Antonello A, Hünger U, Smith MD, Ley SV. Total synthesis of five thapsigargins: guaianolide natural products exhibiting sub-nanomolar SERCA inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 5688-712. PMID 17508363 DOI: 10.1002/chem.200700302  0.56
2007 Andrews SP, Tait MM, Ball M, Ley SV. Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin. Organic & Biomolecular Chemistry. 5: 1427-36. PMID 17464412 DOI: 10.1039/b702481a  0.48
2007 Baxendale IR, Hayward JJ, Ley SV, Tranmer GK. Pharmaceutical strategy and innovation: an academics perspective. Chemmedchem. 2: 768-88. PMID 17458911 DOI: 10.1002/cmdc.200700008  0.56
2007 Bull JA, Balskus EP, Horan RA, Langner M, Ley SV. Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 5515-38. PMID 17440905 DOI: 10.1002/chem.200700033  1
2007 Ley SV, Polara A. A fascination with 1,2-diacetals. The Journal of Organic Chemistry. 72: 5943-59. PMID 17430000 DOI: 10.1021/jo0703451  0.4
2007 Robertson SL, Ni W, Dhadialla TS, Nisbet AJ, McCusker C, Ley SV, Mordue W, Mordue 'Luntz' AJ. Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells. Archives of Insect Biochemistry and Physiology. 64: 200-8. PMID 17366600 DOI: 10.1002/arch.20171  1
2007 Griffiths-Jones CM, Hopkin MD, Jönsson D, Ley SV, Tapolczay DJ, Vickerstaffe E, Ladlow M. Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system. Journal of Combinatorial Chemistry. 9: 422-30. PMID 17348713 DOI: 10.1021/cc060152b  0.48
2007 Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, Beltran M, Neidle S. Chemical variation of natural-product-like scaffolds: Design, synthesis, and biological activity of fused bicyclic acetal derivatives Angewandte Chemie - International Edition. 46: 2493-2496. PMID 17318936 DOI: 10.1002/anie.200604688  1
2007 Ball M, Andrews SP, Wierschem F, Cleator E, Smith MD, Ley SV. Total synthesis of thapsigargin, a potent SERCA pump inhibitor. Organic Letters. 9: 663-6. PMID 17256950 DOI: 10.1021/ol062947x  0.56
2007 Maddess ML, Tackett MN, Watanabe H, Brennan PE, Spilling CD, Scott JS, Osborn DP, Ley SV. Total synthesis of rapamycin. Angewandte Chemie (International Ed. in English). 46: 591-7. PMID 17154218 DOI: 10.1002/anie.200604053  1
2007 Ley SV, Sheppard TD, Myers RM, Chorghade MS. Chiral glycolate equivalents for the asymmetric synthesis of α-hydroxycarbonyl compounds Bulletin of the Chemical Society of Japan. 80: 1451-1472. DOI: 10.1246/bcsj.80.1451  1
2006 Baxendale IR, Ley SV. Solid supported reagents in multi-step flow synthesis. Ernst Schering Foundation Symposium Proceedings. 151-85. PMID 17695715  0.56
2006 Hansen HM, Longbottom DA, Ley SV. A new asymmetric organocatalytic nitrocyclopropanation reaction. Chemical Communications (Cambridge, England). 4838-40. PMID 17345746  0.48
2006 Baxendale IR, Ley SV, Smith CD, Tranmer GK. A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols. Chemical Communications (Cambridge, England). 4835-7. PMID 17345745 DOI: 10.1039/b612197g  1
2006 Baumann M, Baxendale IR, Ley SV, Smith CD, Tranmer GK. Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles. Organic Letters. 8: 5231-4. PMID 17078685 DOI: 10.1021/ol061975c  1
2006 Kumarn S, Shaw DM, Ley SV. A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones. Chemical Communications (Cambridge, England). 3211-3. PMID 17028746 DOI: 10.1039/b606338a  1
2006 Bull JA, Balskus EP, Horan RA, Langner M, Ley SV. Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties. Angewandte Chemie (International Ed. in English). 45: 6714-8. PMID 16986186 DOI: 10.1002/anie.200602050  1
2006 Johansson CC, Bremeyer N, Ley SV, Owen DR, Smith SC, Gaunt MJ. Enantioselective catalytic intramolecular cyclopropanation using modified cinchona alkaloid organocatalysts. Angewandte Chemie (International Ed. in English). 45: 6024-8. PMID 16888822 DOI: 10.1002/anie.200602129  1
2006 Baxendale IR, Deeley J, Griffiths-Jones CM, Ley SV, Saaby S, Tranmer GK. A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. Chemical Communications (Cambridge, England). 2566-8. PMID 16779479 DOI: 10.1039/b600382f  0.56
2006 Mitchell CE, Brenner SE, García-Fortanet J, Ley SV. An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones. Organic & Biomolecular Chemistry. 4: 2039-49. PMID 16688349 DOI: 10.1039/b601877g  1
2006 Zinzalla G, Milroy LG, Ley SV. Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives. Organic & Biomolecular Chemistry. 4: 1977-2002. PMID 16688343 DOI: 10.1039/b603015g  1
2006 Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, et al. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature. 440: 1217-21. PMID 16642000 DOI: 10.1038/nature04672  1
2006 Tate EW, Dixon DJ, Ley SV. A highly enantioselective total synthesis of (+)-goniodiol. Organic & Biomolecular Chemistry. 4: 1698-706. PMID 16633562 DOI: 10.1039/b602805e  1
2006 Knudsen KR, Stepan AF, Michel P, Ley SV. Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives. Organic & Biomolecular Chemistry. 4: 1471-3. PMID 16604212 DOI: 10.1039/b601888b  1
2006 Baxendale IR, Griffiths-Jones CM, Ley SV, Tranmer GK. Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 4407-16. PMID 16586523 DOI: 10.1002/chem.200501400  0.56
2006 Sneddon HF, van den Heuvel A, Hirsch AK, Booth RA, Shaw DM, Gaunt MJ, Ley SV. Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds. The Journal of Organic Chemistry. 71: 2715-25. PMID 16555825 DOI: 10.1021/jo052514s  1
2005 Ley SV, Dixon DJ, Guy RT, Rodríguez F, Sheppard TD. Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives. Organic & Biomolecular Chemistry. 3: 4095-107. PMID 16267589 DOI: 10.1039/b512410g  0.96
2005 Søhoel H, Liljefors T, Ley SV, Oliver SF, Antonello A, Smith MD, Olsen CE, Isaacs JT, Christensen SB. Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin. Journal of Medicinal Chemistry. 48: 7005-11. PMID 16250659 DOI: 10.1021/jm058036v  1
2005 Mitchell CE, Brenner SE, Ley SV. A versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Chemical Communications (Cambridge, England). 5346-8. PMID 16244750 DOI: 10.1039/b511441a  1
2005 Kumarn S, Shaw DM, Longbottom DA, Ley SV. A highly selective, organocatalytic route to chiral dihydro-1,2-oxazines. Organic Letters. 7: 4189-91. PMID 16146384 DOI: 10.1021/ol051577u  1
2005 Saaby S, Baxendale IR, Ley SV. Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes. Organic & Biomolecular Chemistry. 3: 3365-8. PMID 16132098 DOI: 10.1039/b509540a  0.56
2005 Siu J, Baxendale IR, Lewthwaite RA, Ley SV. A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis Organic and Biomolecular Chemistry. 3: 3140-3160. PMID 16106295 DOI: 10.1039/b503778f  0.56
2005 Ball M, Gaunt MJ, Hook DF, Jessiman AS, Kawahara S, Orsini P, Scolaro A, Talbot AC, Tanner HR, Yamanoi S, Ley SV. Total synthesis of spongistatin 1: a synthetic strategy exploiting its latent pseudo-symmetry. Angewandte Chemie (International Ed. in English). 44: 5433-8. PMID 16059947 DOI: 10.1002/anie.200502008  1
2005 Saaby S, Knudsen KR, Ladlow M, Ley SV. The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines. Chemical Communications (Cambridge, England). 2909-11. PMID 15957022 DOI: 10.1039/b504854k  0.48
2005 Brittain DE, Griffiths-Jones CM, Linder MR, Smith MD, McCusker C, Barlow JS, Akiyama R, Yasuda K, Ley SV. Total synthesis of antascomicin B. Angewandte Chemie (International Ed. in English). 44: 2732-7. PMID 15806607 DOI: 10.1002/anie.200500174  0.56
2005 Burke LT, Dixon DJ, Ley SV, Rodríguez F. Total synthesis of the Fusarium toxin equisetin. Organic & Biomolecular Chemistry. 3: 274-80. PMID 15632969 DOI: 10.1039/b411350k  0.96
2005 Cobb AJ, Shaw DM, Longbottom DA, Gold JB, Ley SV. Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions. Organic & Biomolecular Chemistry. 3: 84-96. PMID 15602602 DOI: 10.1039/b414742a  1
2005 Nattrass GL, Díez E, McLachlan MM, Dixon DJ, Ley SV. The total synthesis of the annonaceous acetogenin 10-hydroxyasimicin. Angewandte Chemie (International Ed. in English). 44: 580-4. PMID 15597387 DOI: 10.1002/anie.200462264  0.96
2004 Bremeyer N, Smith SC, Ley SV, Gaunt MJ. An intramolecular organocatalytic cyclopropanation reaction. Angewandte Chemie (International Ed. in English). 43: 2681-4. PMID 18629989 DOI: 10.1002/anie.200454007  1
2004 Ley SV, Dixon DJ, Guy RT, Palomero MA, Polara A, Rodriguez F, Sheppard TD. Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides. Organic & Biomolecular Chemistry. 2: 3618-27. PMID 15592620 DOI: 10.1039/b412790k  0.96
2004 Ley SV, Diez E, Dixon DJ, Guy RT, Michel P, Nattrass GL, Sheppard TD. Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to alpha-hydroxyacid and amide derivatives. Organic & Biomolecular Chemistry. 2: 3608-17. PMID 15592619 DOI: 10.1039/b412788a  0.96
2004 Papageorgiou CD, Cubillo de Dios MA, Ley SV, Gaunt MJ. Enantioselective organocatalytic cyclopropanation via ammonium ylides. Angewandte Chemie (International Ed. in English). 43: 4641-4. PMID 15352192 DOI: 10.1002/anie.200460234  1
2004 Hewitt PR, Cleator E, Ley SV. A concise total synthesis of (+)-okaramine C. Organic & Biomolecular Chemistry. 2: 2415-7. PMID 15326519 DOI: 10.1039/B410180D  1
2004 Cobb AJ, Longbottom DA, Shaw DM, Ley SV. 5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins. Chemical Communications (Cambridge, England). 1808-9. PMID 15306894 DOI: 10.1039/b409646k  1
2004 Ley SV, Antonello A, Balskus EP, Booth DT, Christensen SB, Cleator E, Gold H, Högenauer K, Hünger U, Myers RM, Oliver SF, Simic O, Smith MD, Søhoel H, Woolford AJ. Synthesis of the thapsigargins. Proceedings of the National Academy of Sciences of the United States of America. 101: 12073-8. PMID 15226504 DOI: 10.1073/pnas.0403300101  1
2004 Vickerstaffe E, Warrington BH, Ladlow M, Ley SV. Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles. Journal of Combinatorial Chemistry. 6: 332-9. PMID 15132592 DOI: 10.1021/cc049977g  0.48
2004 Buffet MF, Dixon DJ, Ley SV, Reynolds DJ, Storer RI. Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (gamma)- and pyranyl (delta)-lactols. Organic & Biomolecular Chemistry. 2: 1145-54. PMID 15064790 DOI: 10.1039/b316858a  0.96
2003 Oliver SF, Högenauer K, Simic O, Antonello A, Smith MD, Ley SV. A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. Angewandte Chemie (International Ed. in English). 42: 5996-6000. PMID 14679553 DOI: 10.1002/anie.200353140  0.56
2003 Lee AL, Ley SV. The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers Organic and Biomolecular Chemistry. 1: 3957-3966. PMID 14664385 DOI: 10.1039/b308761a  1
2003 Gaunt MJ, Jessiman AS, Orsini P, Tanner HR, Hook DF, Ley SV. Synthesis of the C-1-C-28 ABCD unit of spongistatin 1. Organic Letters. 5: 4819-22. PMID 14653682 DOI: 10.1021/ol035849+  1
2003 Gaunt MJ, Hook DF, Tanner HR, Ley SV. A practical and efficient synthesis of the C-16-C-28 spiroketal fragment (CD) of the spongistatins. Organic Letters. 5: 4815-8. PMID 14653681 DOI: 10.1021/ol035848h  1
2003 Smith MD, Stepan AF, Ramarao C, Brennan PE, Ley SV. Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings. Chemical Communications (Cambridge, England). 2652-3. PMID 14649794  1
2003 Gaunt MJ, Sneddon HF, Hewitt PR, Orsini P, Hook DF, Ley SV. Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis. Organic & Biomolecular Chemistry. 1: 15-6. PMID 12929380  1
2003 Sneddon HF, Gaunt MJ, Ley SV. Addition of dithiols to bis-ynones: development of a versatile platform for the synthesis of polyketide natural products. Organic Letters. 5: 1147-50. PMID 12659595 DOI: 10.1021/ol034248f  1
2003 Dixon DJ, Harding CI, Ley SV, Tilbrook DM. A 2,3-butanedione protected chiral glycine equivalent--a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids. Chemical Communications (Cambridge, England). 468-9. PMID 12638953  0.96
2003 Papageorgiou CD, Ley SV, Gaunt MJ. Organic-catalyst-mediated cyclopropanation reaction. Angewandte Chemie (International Ed. in English). 42: 828-31. PMID 12596214 DOI: 10.1002/anie.200390222  1
2002 Kiyota H, Dixon DJ, Luscombe CK, Hettstedt S, Ley SV. Synthesis, structure revision, and absolute configuration of (+)-didemniserinolipid B, a serinol marine natural product from a tunicate Didemnum sp. Organic Letters. 4: 3223-6. PMID 12227754 DOI: 10.1021/ol026421y  1
2002 Longbottom DA, Morrison AJ, Dixon DJ, Ley SV. Total synthesis of polycephalin C and determination of the absolute configurations at the 3",4" ring junction. Angewandte Chemie (International Ed. in English). 41: 2786-90. PMID 12203486 DOI: 10.1002/1521-3773(20020802)41:15<2786::AID-ANIE2786>3.0.CO;2-Z  0.96
2002 Ley SV, Ramarao C, Gordon RS, Holmes AB, Morrison AJ, McConvey IF, Shirley IM, Smith SC, Smith MD. Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media. Chemical Communications (Cambridge, England). 1134-5. PMID 12122701  1
2002 Dixon DJ, Ley SV, Reynolds DJ. The total synthesis of the annonaceous acetogenin, muricatetrocin C. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 1621-36. PMID 11933090 DOI: 10.1002/1521-3765(20020402)8:7<1621::AID-CHEM1621>3.0.CO;2-8  0.96
2001 Díez E, Dixon DJ, Ley SV. Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids. Angewandte Chemie (International Ed. in English). 40: 2906-2909. PMID 29711969 DOI: 10.1002/1521-3773(20010803)40:15<2906::AID-ANIE2906>3.0.CO;2-5  0.96
2001 Dixon DJ, Ley SV, Rodríguez F. Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative We gratefully acknowledge financial support from the EPSRC (to D.J.D.), the EU (Marie Curie Fellowship to F.R.), and the Novartis Research Fellowship (to S.V.L.). We are also indebted to Dr. John E. Davis for the X-ray crystal structure determinations. Angewandte Chemie (International Ed. in English). 40: 4763-4765. PMID 12404410 DOI: 10.1002/1521-3773(20011217)40:24<4763::AID-ANIE4763>3.0.CO;2-D  0.96
2001 Ley SV, Ramarao C, Smith MD. Tetra-N-propylammonium perruthenate: a case study in catalyst recovery and re-use involving tetraalkylammonium salts. Chemical Communications (Cambridge, England). 2278-9. PMID 12240149  0.56
2001 Díez E, Dixon DJ, Ley SV. Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure alpha-Hydroxy Acids We thank the EU (Marie Curie Fellowship to E.D.), the EPSRC (to D.J.D.), the Novartis Research Fellowship (to S.V.L.), and Pfizer Gobal Research and Development, Groton, USA, for financial support. Angewandte Chemie (International Ed. in English). 40: 2906-2909. PMID 11500905 DOI: 10.1002/1521-3773(20010803)40:15<2906::AID-ANIE2906>3.0.CO;2-5  0.96
2001 Nisbet AJ, Mordue Luntz AJ, Grossman RB, Jennens L, Ley SV, Mordue W. Characterization of azadirachtin binding to Sf9 nuclei in vitro. Archives of Insect Biochemistry and Physiology. 46: 78-86. PMID 11276064 DOI: 10.1002/arch.11  1
1977 Barton DH, Ley SV, Magnus PD, Rosenfeld MN. Experiments on the synthesis of tetracycline. Part 15. Oxidation of phenols and ring A model phenols to o-hydroxy-dienones with benzeneseleninic anhydride. Journal of the Chemical Society. Perkin Transactions 1. 567-72. PMID 557487 DOI: 10.1016/S0022-3476(80)80388-X  1
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