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Shamil R. Sunyaev - Publications

Affiliations: 
Genetics Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
Area:
computational biology
Website:
http://www.fas.harvard.edu/~biophys/Shamil_Sunyaev.htm

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, ... ... Sunyaev SR, et al. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. Npj Genomic Medicine. 3: 21. PMID 30131872 DOI: 10.1038/S41525-018-0060-9  0.4
2017 Sohail M, Vakhrusheva OA, Sul JH, Pulit SL, Francioli LC, van den Berg LH, Veldink JH, de Bakker PIW, Bazykin GA, Kondrashov AS, Sunyaev SR. Negative selection in humans and fruit flies involves synergistic epistasis. Science (New York, N.Y.). 356: 539-542. PMID 28473589 DOI: 10.1126/Science.Aah5238  0.36
2016 Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics. PMID 26808112 DOI: 10.1038/Ng.3493  0.72
2016 Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE. Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society. Human Mutation. PMID 26791113 DOI: 10.1002/Humu.22958  0.72
2015 Palamara PF, Francioli LC, Wilton PR, Genovese G, Gusev A, Finucane HK, Sankararaman S, Sunyaev SR, de Bakker PI, Wakeley J, Pe'er I, Price AL. Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates. American Journal of Human Genetics. PMID 26581902 DOI: 10.1016/J.Ajhg.2015.10.006  0.72
2015 Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell Reports. PMID 26527001 DOI: 10.1016/J.Celrep.2015.09.077  0.72
2015 Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D. An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood. Rheumatology (Oxford, England). PMID 26493744 DOI: 10.1093/Rheumatology/Kev367  0.72
2015 Balick DJ, Do R, Cassa CA, Reich D, Sunyaev SR. Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck. Plos Genetics. 11: e1005436. PMID 26317225 DOI: 10.1371/Journal.Pgen.1005436  0.72
2015 Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TW, Abecasis G, Becker J, Boeckxstaens GE, Chen WM, Franke A, Gladman DD, ... ... Sunyaev SR, et al. Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics. PMID 26258845 DOI: 10.1038/Ng.3379  0.72
2015 Jordan DM, Frangakis SG, Golzio C, Cassa CA, Kurtzberg J, Davis EE, Sunyaev SR, Katsanis N. Identification of cis-suppression of human disease mutations by comparative genomics. Nature. 524: 225-9. PMID 26123021 DOI: 10.1038/Nature14497  0.72
2015 Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, ... ... Sunyaev SR, et al. Genome-wide patterns and properties of de novo mutations in humans. Nature Genetics. PMID 25985141 DOI: 10.1038/Ng.3292  0.72
2015 Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, ... ... Sunyaev S, et al. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 161: 647-60. PMID 25910212 DOI: 10.1016/J.Cell.2015.04.013  0.72
2015 Polak P, Karli? R, Koren A, Thurman R, Sandstrom R, Lawrence MS, Reynolds A, Rynes E, Vlahovi?ek K, Stamatoyannopoulos JA, Sunyaev SR. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 518: 360-4. PMID 25693567 DOI: 10.1038/Nature14221  0.72
2015 Do R, Balick D, Li H, Adzhubei I, Sunyaev S, Reich D. No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans. Nature Genetics. 47: 126-31. PMID 25581429 DOI: 10.1038/Ng.3186  0.72
2015 Kong SW, Lee IH, Leshchiner I, Krier J, Kraft P, Rehm HL, Green RC, Kohane IS, MacRae CA. Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 17: 536-44. PMID 25341114 DOI: 10.1038/gim.2014.143  0.72
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Sunyaev S, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/Nejmoa1405386  0.72
2014 Francioli LC, Menelaou A, Pulit SL, Van Dijk F, Palamara PF, Elbers CC, Neerincx PBT, Ye K, Guryev V, Kloosterman WP, Deelen P, Abdellaoui A, Van Leeuwen EM, Van Oven M, Vermaat M, ... ... Sunyaev SR, et al. Whole-genome sequence variation, population structure and demographic history of the Dutch population Nature Genetics. 46: 818-825. PMID 24974849 DOI: 10.1038/Ng.3021  0.72
2014 MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, ... ... Sunyaev SR, et al. Guidelines for investigating causality of sequence variants in human disease. Nature. 508: 469-76. PMID 24759409 DOI: 10.1038/Nature13127  0.72
2014 Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, ... ... Sunyaev SR, et al. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology. 15: R53. PMID 24667040 DOI: 10.1186/Gb-2014-15-3-R53  0.72
2014 Vassy JL, Lautenbach DM, McLaughlin HM, Kong SW, Christensen KD, Krier J, Kohane IS, Feuerman LZ, Blumenthal-Barby J, Roberts JS, Lehmann LS, Ho CY, Ubel PA, MacRae CA, Seidman CE, et al. The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials. 15: 85. PMID 24645908 DOI: 10.1186/1745-6215-15-85  0.72
2014 Stanley CM, Sunyaev SR, Greenblatt MS, Oetting WS. Clinically relevant variants - identifying, collecting, interpreting, and disseminating: the 2013 annual scientific meeting of the Human Genome Variation Society. Human Mutation. 35: 505-10. PMID 24470180 DOI: 10.1002/Humu.22516  0.72
2014 Zuk O, Schaffner SF, Samocha K, Do R, Hechter E, Kathiresan S, Daly MJ, Neale BM, Sunyaev SR, Lander ES. Searching for missing heritability: designing rare variant association studies. Proceedings of the National Academy of Sciences of the United States of America. 111: E455-64. PMID 24443550 DOI: 10.1073/Pnas.1322563111  0.72
2014 Polak P, Lawrence MS, Haugen E, Stoletzki N, Stojanov P, Thurman RE, Garraway LA, Mirkin S, Getz G, Stamatoyannopoulos JA, Sunyaev SR. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nature Biotechnology. 32: 71-5. PMID 24336318 DOI: 10.1038/Nbt.2778  0.72
2013 Sunagawa S, Schloissnig S, Arumugam M, Forslund K, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Typas A, Weinstock GM, et al. Individuality and temporal stability of the human gut microbiome. Central Asian Journal of Global Health. 2: 120. PMID 29805877 DOI: 10.5195/Cajgh.2013.120  0.72
2013 Sunyaev SR, Roth FP. Systems biology and the analysis of genetic variation. Current Opinion in Genetics & Development. 23: 599-601. PMID 24291212 DOI: 10.1016/J.Gde.2013.11.010  0.72
2013 Agarwala V, Flannick J, Sunyaev S, Altshuler D. Evaluating empirical bounds on complex disease genetic architecture. Nature Genetics. 45: 1418-27. PMID 24141362 DOI: 10.1038/Ng.2804  0.72
2013 Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, ... ... Sunyaev SR, et al. Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nature Communications. 4: 2212. PMID 23962925 DOI: 10.1038/Ncomms3212  0.72
2013 Goldstein DB, Allen A, Keebler J, Margulies EH, Petrou S, Petrovski S, Sunyaev S. Sequencing studies in human genetics: design and interpretation. Nature Reviews. Genetics. 14: 460-70. PMID 23752795 DOI: 10.1038/Nrg3455  0.72
2013 Gokcumen O, Zhu Q, Mulder LC, Iskow RC, Austermann C, Scharer CD, Raj T, Boss JM, Sunyaev S, Price A, Stranger B, Simon V, Lee C. Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence. Plos Genetics. 9: e1003404. PMID 23593015 DOI: 10.1371/Journal.Pgen.1003404  0.72
2013 Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, Steen VM, Mathur J, Cox J, Lebo M, Rehm H, ... ... Sunyaev SR, et al. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proceedings of the National Academy of Sciences of the United States of America. 110: 4667-72. PMID 23487782 DOI: 10.1073/Pnas.1221400110  0.72
2013 Kiezun A, Pulit SL, Francioli LC, van Dijk F, Swertz M, Boomsma DI, van Duijn CM, Slagboom PE, van Ommen GJ, Wijmenga C, de Bakker PI, Sunyaev SR. Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. Plos Genetics. 9: e1003301. PMID 23468643 DOI: 10.1371/Journal.Pgen.1003301  0.72
2013 McFarland CD, Korolev KS, Kryukov GV, Sunyaev SR, Mirny LA. Impact of deleterious passenger mutations on cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 110: 2910-5. PMID 23388632 DOI: 10.1073/Pnas.1213968110  0.72
2013 Adzhubei I, Jordan DM, Sunyaev SR. Predicting functional effect of human missense mutations using PolyPhen-2. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit7.20. PMID 23315928 DOI: 10.1002/0471142905.Hg0720S76  0.72
2013 Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, ... ... Sunyaev S, et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. American Journal of Human Genetics. 92: 15-27. PMID 23261300 DOI: 10.1016/J.Ajhg.2012.11.012  0.72
2013 Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Weinstock GM, Bork P. Genomic variation landscape of the human gut microbiome. Nature. 493: 45-50. PMID 23222524 DOI: 10.1038/Nature11711  0.72
2013 Thompson BA, Greenblatt MS, Vallee MP, Herkert JC, Tessereau C, Young EL, Adzhubey IA, Li B, Bell R, Feng B, Mooney SD, Radivojac P, Sunyaev SR, Frebourg T, Hofstra RM, et al. Calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions. Human Mutation. 34: 255-65. PMID 22949387 DOI: 10.1002/Humu.22214  0.72
2012 Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA. Differential relationship of DNA replication timing to different forms of human mutation and variation. American Journal of Human Genetics. 91: 1033-40. PMID 23176822 DOI: 10.1016/J.Ajhg.2012.10.018  0.72
2012 Nusinow DP, Kiezun A, O'Connell DJ, Chick JM, Yue Y, Maas RL, Gygi SP, Sunyaev SR. Network-based inference from complex proteomic mixtures using SNIPE. Bioinformatics (Oxford, England). 28: 3115-22. PMID 23060611 DOI: 10.1093/Bioinformatics/Bts594  0.72
2012 Sunyaev SR. Inferring causality and functional significance of human coding DNA variants. Human Molecular Genetics. 21: R10-7. PMID 22990389 DOI: 10.1093/Hmg/Dds385  0.72
2012 Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, Shafer A, Neri F, Lee K, Kutyavin T, Stehling-Sun S, ... ... Sunyaev SR, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science (New York, N.Y.). 337: 1190-5. PMID 22955828 DOI: 10.1126/Science.1222794  0.72
2012 Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, ... ... Sunyaev SR, et al. The accessible chromatin landscape of the human genome. Nature. 489: 75-82. PMID 22955617 DOI: 10.1038/Nature11232  0.72
2012 Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, ... ... Sunyaev SR, et al. Exome sequencing and the genetic basis of complex traits. Nature Genetics. 44: 623-30. PMID 22641211 DOI: 10.1038/Ng.2303  0.72
2012 Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, ... ... Sunyaev S, et al. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nature Genetics. 44: 631-5. PMID 22610117 DOI: 10.1038/Ng.2283  0.72
2012 Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, ... ... Sunyaev S, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.). 337: 64-9. PMID 22604720 DOI: 10.1126/Science.1219240  0.72
2012 Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, ... ... Sunyaev SR, et al. Mutation mapping and identification by whole-genome sequencing. Genome Research. 22: 1541-8. PMID 22555591 DOI: 10.1101/Gr.135541.111  0.72
2012 Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, ... ... Sunyaev S, et al. The interface of protein structure, protein biophysics, and molecular evolution. Protein Science : a Publication of the Protein Society. 21: 769-85. PMID 22528593 DOI: 10.1002/Pro.2071  0.72
2012 Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, ... ... Sunyaev S, et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature. 485: 242-5. PMID 22495311 DOI: 10.1038/Nature11011  0.72
2012 Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America. 109: 1193-8. PMID 22223662 DOI: 10.1073/Pnas.1119675109  0.72
2012 Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, Celedón JC, Avila L, Soto-Quiros ME, Weiss ST. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. The Journal of Allergy and Clinical Immunology. 129: 368-73, 373.e1-5. PMID 22051697 DOI: 10.1016/J.Jaci.2011.09.034  0.72
2011 Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, ... ... Sunyaev SR, et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 479: 223-7. PMID 21993625 DOI: 10.1038/Nature10533  0.72
2011 Stitziel NO, Kiezun A, Sunyaev S. Computational and statistical approaches to analyzing variants identified by exome sequencing Genome Biology. 12. PMID 21920052 DOI: 10.1186/Gb-2011-12-9-227  0.72
2011 Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, et al. Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity. The Journal of Infectious Diseases. 204: 103-14. PMID 21628664 DOI: 10.1093/Infdis/Jir198  0.72
2011 Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, Sunyaev SR. Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. American Journal of Human Genetics. 88: 183-92. PMID 21310275 DOI: 10.1016/J.Ajhg.2011.01.011  0.72
2011 Spirin V, Shpunt A, Seebacher J, Gentzel M, Shevchenko A, Gygi S, Sunyaev S. Assigning spectrum-specific P-values to protein identifications by mass spectrometry Bioinformatics. 27: 1128-1134. DOI: 10.1093/Bioinformatics/Btr089  0.72
2010 Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ, Sunyaev SR. Pooled association tests for rare variants in exon-resequencing studies. American Journal of Human Genetics. 86: 832-8. PMID 20471002 DOI: 10.1016/J.Ajhg.2010.05.014  0.72
2010 Jordan DM, Ramensky VE, Sunyaev SR. Human allelic variation: perspective from protein function, structure, and evolution. Current Opinion in Structural Biology. 20: 342-50. PMID 20399638 DOI: 10.1016/J.Sbi.2010.03.006  0.72
2010 Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations. Nature Methods. 7: 248-9. PMID 20354512 DOI: 10.1038/Nmeth0410-248  0.72
2010 Price AL, Kryukov GV, de Bakker PIW, Purcell SM, Staples J, Wei LJ, Sunyaev SR. Pooled Association Tests for Rare Variants in Exon-Resequencing Studies (DOI:10.1016/j.ajhg.2010.04.005) American Journal of Human Genetics. 86: 982. DOI: 10.1016/j.ajhg.2010.05.014  0.72
2009 Molla M, Delcher A, Sunyaev S, Cantor C, Kasif S. Triplet repeat length bias and variation in the human transcriptome Proceedings of the National Academy of Sciences of the United States of America. 106: 17095-17100. PMID 19805156 DOI: 10.1073/Pnas.0907112106  0.72
2009 Stamatoyannopoulos JA, Adzhubei I, Thurman RE, Kryukov GV, Mirkin SM, Sunyaev SR. Human mutation rate associated with DNA replication timing. Nature Genetics. 41: 393-5. PMID 19287383 DOI: 10.1038/Ng.363  0.72
2009 Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR. Power of deep, all-exon resequencing for discovery of human trait genes. Proceedings of the National Academy of Sciences of the United States of America. 106: 3871-6. PMID 19202052 DOI: 10.1073/Pnas.0812824106  0.72
2009 Sunyaev SR, Lugovskoy A, Simon K, Gorelik L. Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). Plos Genetics. 5: e1000368. PMID 19197354 DOI: 10.1371/Journal.Pgen.1000368  0.72
2009 Ramensky VE, Sunyaev SR. Computational analysis of human genome polymorphism Molecular Biology. 43: 260-268. DOI: 10.1134/S0026893309020095  0.72
2009 Sunyaev SR. Interpreting population sequencing data (Invited keynote talk) Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 5542: 234-235. DOI: 10.1007/978-3-642-01551-9_23  0.72
2008 Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS, Sunyaev S. Erratum. Plos Genetics. 4. PMID 19096535 DOI: 10.1371/Annotation/A81B1Fab-890C-447B-A308-5Bc8Ca3Eb21D  0.68
2008 Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S. Hypermutable non-synonymous sites are under stronger negative selection. Plos Genetics. 4: e1000281. PMID 19043566 DOI: 10.1371/Journal.Pgen.1000281  0.72
2008 Beckstead WA, Bjork BC, Stottmann RW, Sunyaev S, Beier DR. SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 687-90. PMID 18958524 DOI: 10.1007/S00335-008-9149-2  0.72
2008 Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A. Protein identification pipeline for the homology-driven proteomics Journal of Proteomics. 71: 346-356. PMID 18639657 DOI: 10.1016/J.Jprot.2008.07.003  0.72
2008 Junqueira M, Spirin V, Santana Balbuena T, Waridel P, Surendranath V, Kryukov G, Adzhubei I, Thomas H, Sunyaev S, Shevchenko A. Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification. Journal of Proteome Research. 7: 3382-95. PMID 18558732 DOI: 10.1021/Pr800140V  0.72
2008 Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD. Assessing the evolutionary impact of amino acid mutations in the human genome. Plos Genetics. 4: e1000083. PMID 18516229 DOI: 10.1371/Journal.Pgen.1000083  0.72
2008 Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD. Proportionally more deleterious genetic variation in European than in African populations. Nature. 451: 994-7. PMID 18288194 DOI: 10.1038/Nature06611  0.72
2008 Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. American Journal of Human Genetics. 82: 100-12. PMID 18179889 DOI: 10.1016/J.Ajhg.2007.09.006  0.72
2008 Ballif BA, Carey GR, Sunyaev SR, Gygi SP. Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. Journal of Proteome Research. 7: 311-8. PMID 18034455 DOI: 10.1021/Pr0701254  0.72
2007 Asthana S, Roytberg M, Stamatoyannopoulos J, Sunyaev S. Analysis of sequence conservation at nucleotide resolution Plos Computational Biology. 3: e254. PMID 18166073 DOI: 10.1371/Journal.Pcbi.0030254  0.72
2007 Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, Sunyaev SR. Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. American Journal of Human Genetics. 81: 1298-303. PMID 17952847 DOI: 10.1086/522497  0.72
2007 Ilyinskii PO, Gabai VL, Sunyaev SR, Thoidis G, Shneider AM. Toxicity of influenza A virus matrix protein 2 for mammalian cells is associated with its intrinsic proton-channeling activity. Cell Cycle (Georgetown, Tex.). 6: 2043-7. PMID 17700063 DOI: 10.4161/Cc.6.16.4564  0.72
2007 Asthana S, Noble WS, Kryukov G, Grant CE, Sunyaev S, Stamatoyannopoulos JA. Widely distributed noncoding purifying selection in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 104: 12410-5. PMID 17640883 DOI: 10.1073/Pnas.0705140104  0.72
2007 Waridel P, Frank A, Thomas H, Surendranath V, Sunyaev S, Pevzner P, Shevchenko A. Sequence similarity-driven proteomics in organisms with unknown genomes by LC-MS/MS and automated de novo sequencing. Proteomics. 7: 2318-29. PMID 17623296 DOI: 10.1002/Pmic.200700003  0.72
2007 Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, ... ... Sunyaev S, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447: 799-816. PMID 17571346 DOI: 10.1038/Nature05874  0.72
2007 Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, et al. Medical sequencing at the extremes of human body mass. American Journal of Human Genetics. 80: 779-91. PMID 17357083 DOI: 10.1086/513471  0.72
2007 Kryukov GV, Pennacchio LA, Sunyaev SR. Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. American Journal of Human Genetics. 80: 727-39. PMID 17357078 DOI: 10.1086/513473  0.72
2006 Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Koonin EV, Kondrashov AS, Sunyaev S. Protein evolution: Causes of trends in amino-acid gain and loss (Reply) Nature. 442: E12. DOI: 10.1038/Nature05138  0.72
2005 Keightley PD, Kryukov GV, Sunyaev S, Halligan DL, Gaffney DJ. Evolutionary constraints in conserved nongenic sequences of mammals. Genome Research. 15: 1373-8. PMID 16204190 DOI: 10.1101/Gr.3942005  0.72
2005 Liska AJ, Sunyaev S, Shilov IN, Schaeffer DA, Shevchenko A. Error-tolerant EST database searches by tandem mass spectrometry and multiTag software Proteomics. 5: 4118-4122. PMID 16121338 DOI: 10.1002/Pmic.200401262  0.72
2005 Kryukov GV, Schmidt S, Sunyaev S. Small fitness effect of mutations in highly conserved non-coding regions. Human Molecular Genetics. 14: 2221-9. PMID 15994173 DOI: 10.1093/Hmg/Ddi226  0.72
2005 Sunyaev S. Biocomputing enters its adolescence Genome Biology. 6. PMID 15960815 DOI: 10.1186/Gb-2005-6-6-325  0.72
2005 Asthana S, Schmidt S, Sunyaev S. A limited role for balancing selection Trends in Genetics. 21: 30-32. PMID 15680511 DOI: 10.1016/J.Tig.2004.11.001  0.72
2005 Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Koonin EV, Kondrashov AS, Sunyaev S. A universal trend of amino acid gain and loss in protein evolution. Nature. 433: 633-8. PMID 15660107 DOI: 10.1038/nature03306  0.72
2004 Liska AJ, Popov AV, Sunyaev S, Coughlin P, Habermann B, Shevchenko A, Bork P, Karsenti E, Shevchenko A. Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome. Proteomics. 4: 2707-21. PMID 15352245 DOI: 10.1002/Pmic.200300813  0.72
2004 Ogurtsov AY, Sunyaev S, Kondrashov AS. Indel-based evolutionary distance and mouse-human divergence. Genome Research. 14: 1610-6. PMID 15289479 DOI: 10.1101/Gr.2450504  0.72
2004 Bazykin GA, Kondrashov FA, Ogurtsov AY, Sunyaev S, Kondrashov AS. Positive selection at sites of multiple amino acid replacements since rat-mouse divergence. Nature. 429: 558-62. PMID 15175752 DOI: 10.1038/Nature02601  0.72
2004 Sunyaev SR, Bogopolsky GA, Oleynikova NV, Vlasov PK, Finkelstein AV, Roytberg MA. From analysis of protein structural alignments toward a novel approach to align protein sequences. Proteins. 54: 569-82. PMID 14748004 DOI: 10.1002/Prot.10503  0.72
2004 Habermann B, Oegema J, Sunyaev S, Shevchenko A. The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searches Molecular and Cellular Proteomics. 3: 238-249. PMID 14695901 DOI: 10.1074/Mcp.M300073-Mcp200  0.72
2003 Sunyaev S, Kondrashov FA, Bork P, Ramensky V. Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics. 12: 3325-30. PMID 14570704 DOI: 10.1093/Hmg/Ddg359  0.72
2003 Schmidt S, Sunyaev S, Bork P, Dandekar T. Metabolites: a helping hand for pathway evolution? Trends in Biochemical Sciences. 28: 336-41. PMID 12826406 DOI: 10.1016/S0968-0004(03)00114-2  0.72
2003 Sunyaev S, Liska AJ, Golod A, Shevchenko A. MultiTag: Multiple error-tolerant sequence tag search for the sequence-similarity identification of proteins by mass spectrometry Analytical Chemistry. 75: 1307-1315. PMID 12659190 DOI: 10.1021/Ac026199A  0.72
2003 Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S. Increase of functional diversity by alternative splicing. Trends in Genetics : Tig. 19: 124-8. PMID 12615003 DOI: 10.1016/S0168-9525(03)00023-4  0.72
2003 Stark A, Sunyaev S, Russell RB. A model for statistical significance of local similarities in structure. Journal of Molecular Biology. 326: 1307-16. PMID 12595245 DOI: 10.1016/S0022-2836(03)00045-7  0.72
2003 Shevchenko A, Sunyaev S, Liska A, Bork P, Shevchenko A. Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes. Methods in Molecular Biology (Clifton, N.J.). 211: 221-34. PMID 12489434 DOI: 10.1385/1-59259-342-9:221  0.72
2002 Kondrashov AS, Sunyaev S, Kondrashov FA. Dobzhansky-Muller incompatibilities in protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 99: 14878-83. PMID 12403824 DOI: 10.1073/Pnas.232565499  0.72
2002 Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Research. 30: 3894-900. PMID 12202775 DOI: 10.1093/Nar/Gkf493  0.72
2001 Shevchenko A, Sunyaev S, Loboda A, Shevchenko A, Bork P, Ens W, Standing KG. Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching. Analytical Chemistry. 73: 1917-26. PMID 11354471 DOI: 10.1021/AC0013709  0.72
2001 Sunyaev S, Ramensky V, Koch I, Lathe W, Kondrashov AS, Bork P. Prediction of deleterious human alleles. Human Molecular Genetics. 10: 591-7. PMID 11230178 DOI: 10.1093/Hmg/10.6.591  0.72
2001 Sunyaev S, Lathe W, Bork P. Integration of genome data and protein structures: prediction of protein folds, protein interactions and "molecular phenotypes" of single nucleotide polymorphisms. Current Opinion in Structural Biology. 11: 125-30. PMID 11179902 DOI: 10.1016/S0959-440X(00)00175-5  0.72
2000 Sunyaev SR, Lathe WC, Ramensky VE, Bork P. SNP frequencies in human genes an excess of rare alleles and differing modes of selection. Trends in Genetics : Tig. 16: 335-7. PMID 10904261 DOI: 10.1016/S0168-9525(00)02058-8  0.72
2000 Sunyaev S, Hanke J, Brett D, Aydin A, Zastrow I, Lathe W, Bork P, Reich J. Individual variation in protein-coding sequences of human genome. Advances in Protein Chemistry. 54: 409-37. PMID 10829234 DOI: 10.1016/S0065-3233(00)54012-1  0.72
2000 Sunyaev S, Ramensky V, Bork P. Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends in Genetics : Tig. 16: 198-200. PMID 10782110 DOI: 10.1016/S0168-9525(00)01988-0  0.72
1999 Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P. Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes. Journal of Molecular Medicine (Berlin, Germany). 77: 754-60. PMID 10619435 DOI: 10.1007/S001099900059  0.72
1999 Sunyaev SR, Eisenhaber F, Rodchenkov IV, Eisenhaber B, Tumanyan VG, Kuznetsov EN. PSIC: profile extraction from sequence alignments with position-specific counts of independent observations. Protein Engineering. 12: 387-94. PMID 10360979 DOI: 10.1093/Protein/12.5.387  0.72
1999 Sunyaev SR, Eisenhaber F, Tumanyan VG. An approach to the inverse folding problem based on the multiple structural alignment Biofizika. 44: 623.  0.72
1998 Huynen M, Doerks T, Eisenhaber F, Orengo C, Sunyaev S, Yuan Y, Bork P. Homology-based fold predictions for Mycoplasma genitalium proteins. Journal of Molecular Biology. 280: 323-6. PMID 9665839 DOI: 10.1006/Jmbi.1998.1884  0.72
1998 Sunyaev SR, Eisenhaber F, Argos P, Kuznetsov EN, Tumanyan VG. Are knowledge-based potentials derived from protein structure sets discriminative with respect to amino acid types? Proteins. 31: 225-46. PMID 9593195 DOI: 10.1002/(Sici)1097-0134(19980515)31:3<225::Aid-Prot1>3.0.Co;2-I  0.72
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