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Shamil R. Sunyaev - Publications

Affiliations: 
Genetics Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
Area:
computational biology
Website:
http://www.fas.harvard.edu/~biophys/Shamil_Sunyaev.htm

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gao H, Hamp T, Ede J, Schraiber JG, McRae J, Singer-Berk M, Yang Y, Dietrich ASD, Fiziev PP, Kuderna LFK, Sundaram L, Wu Y, Adhikari A, Field Y, Chen C, ... ... Sunyaev S, et al. The landscape of tolerated genetic variation in humans and primates. Science (New York, N.Y.). 380: eabn8153. PMID 37262156 DOI: 10.1126/science.abn8197  0.814
2023 Gao H, Hamp T, Ede J, Schraiber JG, McRae J, Singer-Berk M, Yang Y, Dietrich A, Fiziev P, Kuderna L, Sundaram L, Wu Y, Adhikari A, Field Y, Chen C, ... ... Sunyaev S, et al. The landscape of tolerated genetic variation in humans and primates. Biorxiv : the Preprint Server For Biology. PMID 37205491 DOI: 10.1101/2023.05.01.538953  0.815
2023 Wakeley J, Fan WL, Koch E, Sunyaev S. Recurrent mutation in the ancestry of a rare variant. Genetics. PMID 36967220 DOI: 10.1093/genetics/iyad049  0.301
2022 Connally NJ, Nazeen S, Lee D, Shi H, Stamatoyannopoulos J, Chun S, Cotsapas C, Cassa CA, Sunyaev SR. The missing link between genetic association and regulatory function. Elife. 11. PMID 36515579 DOI: 10.7554/eLife.74970  0.311
2022 Zhou H, Arapoglou T, Li X, Li Z, Zheng X, Moore J, Asok A, Kumar S, Blue EE, Buyske S, Cox N, Felsenfeld A, Gerstein M, Kenny E, Li B, ... ... Sunyaev SR, et al. FAVOR: functional annotation of variants online resource and annotator for variation across the human genome. Nucleic Acids Research. PMID 36350676 DOI: 10.1093/nar/gkac966  0.337
2022 Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, ... ... Sunyaev S, et al. A cross-disorder dosage sensitivity map of the human genome. Cell. PMID 35917817 DOI: 10.1016/j.cell.2022.06.036  0.303
2022 Sharo AG, Hu Z, Sunyaev SR, Brenner SE. StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants. American Journal of Human Genetics. PMID 35032432 DOI: 10.1016/j.ajhg.2021.12.007  0.308
2022 Balick DJ, Jordan DM, Sunyaev S, Do R. Overcoming constraints on the detection of recessive selection in human genes from population frequency data. American Journal of Human Genetics. 109: 33-49. PMID 34951958 DOI: 10.1016/j.ajhg.2021.12.001  0.784
2021 Koch EM, Sunyaev SR. Maintenance of Complex Trait Variation: Classic Theory and Modern Data. Frontiers in Genetics. 12: 763363. PMID 34868244 DOI: 10.3389/fgene.2021.763363  0.323
2021 Radke DW, Sul JH, Balick DJ, Akle S, Green RC, Sunyaev SR. Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy. Genome Research. PMID 33963077 DOI: 10.1101/gr.275263.121  0.779
2021 Shi H, Gazal S, Kanai M, Koch EM, Schoech AP, Siewert KM, Kim SS, Luo Y, Amariuta T, Huang H, Okada Y, Raychaudhuri S, Sunyaev SR, Price AL. Population-specific causal disease effect sizes in functionally important regions impacted by selection. Nature Communications. 12: 1098. PMID 33597505 DOI: 10.1038/s41467-021-21286-1  0.321
2020 Kousi M, Söylemez O, Ozanturk A, Mourtzi N, Akle S, Jungreis I, Muller J, Cassa CA, Brand H, Mokry JA, Wolf MY, Sadeghpour A, McFadden K, Lewis RA, Talkowski ME, ... ... Sunyaev SR, et al. Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy. Nature Genetics. PMID 33046855 DOI: 10.1038/s41588-020-0707-1  0.561
2020 Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, ... ... Sunyaev SR, et al. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nature Genetics. PMID 32839606 DOI: 10.1038/S41588-020-0676-4  0.408
2020 Chun S, Imakaev M, Hui D, Patsopoulos NA, Neale BM, Kathiresan S, Stitziel NO, Sunyaev SR. Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics. American Journal of Human Genetics. PMID 32470373 DOI: 10.1016/J.Ajhg.2020.05.004  0.388
2020 Dietlein F, Weghorn D, Taylor-Weiner A, Richters A, Reardon B, Liu D, Lander ES, Van Allen EM, Sunyaev SR. Identification of cancer driver genes based on nucleotide context. Nature Genetics. PMID 32015527 DOI: 10.1038/S41588-019-0572-Y  0.362
2020 Mohanty AK, Vuzman D, Francioli L, Cassa C, Toth-Petroczy A, Sunyaev S. novoCaller: a Bayesian network approach for de novo variant calling from pedigree and population sequence data. Bioinformatics (Oxford, England). 35: 1174-1180. PMID 30169785 DOI: 10.1093/Bioinformatics/Bty749  0.385
2019 Arnold B, Sohail M, Wadsworth C, Corander J, Hanage WP, Sunyaev S, Grad YH. Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen. Molecular Biology and Evolution. PMID 31589312 DOI: 10.1093/Molbev/Msz225  0.445
2019 Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, ... ... Sunyaev SR, et al. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nature Genetics. PMID 31406347 DOI: 10.1038/S41588-019-0475-Y  0.317
2019 Farhat MR, Freschi L, Calderon R, Ioerger T, Snyder M, Meehan CJ, de Jong B, Rigouts L, Sloutsky A, Kaur D, Sunyaev S, van Soolingen D, Shendure J, Sacchettini J, Murray M. GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. Nature Communications. 10: 2128. PMID 31086182 DOI: 10.1038/S41467-019-10110-6  0.338
2019 Weghorn D, Balick DJ, Cassa C, Kosmicki JA, Daly MJ, Beier DR, Sunyaev SR. Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans. Molecular Biology and Evolution. PMID 31004148 DOI: 10.1093/Molbev/Msz092  0.803
2019 Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, ... ... Sunyaev SR, et al. Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. Plos Genetics. 15: e1007739. PMID 30990817 DOI: 10.1371/Journal.Pgen.1007739  0.343
2019 Sohail M, Maier RM, Ganna A, Bloemendal A, Martin AR, Turchin MC, Chiang CW, Hirschhorn J, Daly MJ, Patterson N, Neale B, Mathieson I, Reich D, Sunyaev SR. Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies. Elife. 8. PMID 30895926 DOI: 10.7554/Elife.39702  0.442
2019 Schoech AP, Jordan DM, Loh PR, Gazal S, O'Connor LJ, Balick DJ, Palamara PF, Finucane HK, Sunyaev SR, Price AL. Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection. Nature Communications. 10: 790. PMID 30770844 DOI: 10.1038/S41467-019-08424-6  0.788
2019 Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR. Reply to 'Selective effects of heterozygous protein-truncating variants'. Nature Genetics. 51: 3-4. PMID 30478437 DOI: 10.1038/S41588-018-0301-Y  0.765
2018 Wang H, Cade BE, Sofer T, Sands SA, Chen H, Browning S, Stilp AM, Louie TL, Thornton TA, Craig Johnson W, Below JE, Conomos MP, Evans DS, Gharib SA, Guo X, ... ... Sunyaev SR, et al. Admixture mapping identifies novel loci for obstructive sleep apnea in hispanic/latino americans. Human Molecular Genetics. PMID 30403821 DOI: 10.1093/Hmg/Ddy387  0.337
2018 Bodea CA, Mitchell AA, Bloemendal A, Day-Williams AG, Runz H, Sunyaev SR. PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants. Genome Biology. 19: 173. PMID 30359302 DOI: 10.1186/S13059-018-1546-6  0.399
2018 Gazal S, Loh PR, Finucane HK, Ganna A, Schoech A, Sunyaev S, Price AL. Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations. Nature Genetics. PMID 30297966 DOI: 10.1038/S41588-018-0231-8  0.365
2018 Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, ... ... Sunyaev SR, et al. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. Npj Genomic Medicine. 3: 21. PMID 30131872 DOI: 10.1038/S41525-018-0060-9  0.377
2018 Cassa CA, Jordan DM, Adzhubei I, Sunyaev S. A literature review at genome scale: improving clinical variant assessment. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 20: 936-941. PMID 29388949 DOI: 10.1038/Gim.2017.230  0.314
2018 Sohail M, Maier RM, Ganna A, Bloemendal A, Martin AR, Turchin MC, Chiang CW, Hirschhorn J, Daly MJ, Patterson N, Neale B, Mathieson I, Reich D, Sunyaev SR. Author response: Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies Elife. DOI: 10.7554/Elife.39702.042  0.328
2017 Weghorn D, Sunyaev S. Bayesian inference of negative and positive selection in human cancers. Nature Genetics. 49: 1785-1788. PMID 29106416 DOI: 10.1038/Ng.3987  0.37
2017 Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, ... ... Sunyaev SR, et al. Multi-ethnic Meta-analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea Related Quantitative Trait Locus in Men. American Journal of Respiratory Cell and Molecular Biology. PMID 29077507 DOI: 10.1165/Rcmb.2017-0237Oc  0.337
2017 D Antonio M, Weghorn D, D Antonio-Chronowska A, Coulet F, Olson KM, DeBoever C, Drees F, Arias A, Alakus H, Richardson AL, Schwab RB, Farley EK, Sunyaev SR, Frazer KA. Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nature Communications. 8: 436. PMID 28874753 DOI: 10.1038/S41467-017-00100-X  0.311
2017 Sohail M, Vakhrusheva OA, Sul JH, Pulit SL, Francioli LC, van den Berg LH, Veldink JH, de Bakker PIW, Bazykin GA, Kondrashov AS, Sunyaev SR. Negative selection in humans and fruit flies involves synergistic epistasis. Science (New York, N.Y.). 356: 539-542. PMID 28473589 DOI: 10.1126/Science.Aah5238  0.491
2017 Chandonia JM, Adhikari A, Carraro M, Chhibber A, Cutting GR, Fu Y, Gasparini A, Jones DT, Kramer A, Kundu K, Lam HY, Leonardi E, Moult J, Pal LR, Searls DB, ... ... Sunyaev S, et al. 3Lessons from the CAGI-4 Hopkins clinical panel challenge. Human Mutation. PMID 28397312 DOI: 10.1002/Humu.23225  0.336
2017 Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR. Estimating the selective effects of heterozygous protein-truncating variants from human exome data. Nature Genetics. PMID 28369035 DOI: 10.1038/Ng.3831  0.779
2017 Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nature Genetics. PMID 28218759 DOI: 10.1038/Ng.3795  0.394
2016 Wang H, Cade BE, Chen H, Gleason KJ, Saxena R, Feng T, Larkin EK, Ramachandran VS, Lin H, Patel SR, Tracy RP, Liu Y, Gottlieb DJ, Below JE, Hanis CL, ... ... Sunyaev SR, et al. Variants in Angiopoietin-2 (ANGPT2) contribute to variation in Nocturnal Oxyhemoglobin Saturation Level. Human Molecular Genetics. PMID 27798093 DOI: 10.1093/Hmg/Ddw324  0.358
2016 Zou J, Valiant G, Valiant P, Karczewski K, Chan SO, Samocha K, Lek M, Sunyaev S, Daly M, MacArthur DG. Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects. Nature Communications. 7: 13293. PMID 27796292 DOI: 10.1038/Ncomms13293  0.468
2016 Sul JH, Cade BE, Cho MH, Qiao D, Silverman EK, Redline S, Sunyaev S. Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees. American Journal of Human Genetics. PMID 27666371 DOI: 10.1016/J.Ajhg.2016.08.015  0.368
2016 Lenz TL, Spirin V, Jordan DM, Sunyaev SR. Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection. Molecular Biology and Evolution. PMID 27436009 DOI: 10.1093/Molbev/Msw127  0.506
2016 Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics. PMID 26808112 DOI: 10.1038/Ng.3493  0.468
2016 Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE. Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society. Human Mutation. PMID 26791113 DOI: 10.1002/Humu.22958  0.435
2015 Palamara PF, Francioli LC, Wilton PR, Genovese G, Gusev A, Finucane HK, Sankararaman S, Sunyaev SR, de Bakker PI, Wakeley J, Pe'er I, Price AL. Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates. American Journal of Human Genetics. PMID 26581902 DOI: 10.1016/J.Ajhg.2015.10.006  0.436
2015 Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell Reports. PMID 26527001 DOI: 10.1016/J.Celrep.2015.09.077  0.337
2015 Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D. An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood. Rheumatology (Oxford, England). PMID 26493744 DOI: 10.1093/Rheumatology/Kev367  0.342
2015 Chopra SS, Leshchiner I, Duzkale H, McLaughlin H, Giovanni M, Zhang C, Stitziel N, Fingeroth J, Joyce RM, Lebo M, Rehm H, Vuzman D, Maas R, Sunyaev SR, Murray M, et al. Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease. Molecular Genetics & Genomic Medicine. 3: 413-23. PMID 26436107 DOI: 10.1002/Mgg3.152  0.307
2015 Balick DJ, Do R, Cassa CA, Reich D, Sunyaev SR. Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck. Plos Genetics. 11: e1005436. PMID 26317225 DOI: 10.1371/Journal.Pgen.1005436  0.783
2015 Jordan DM, Frangakis SG, Golzio C, Cassa CA, Kurtzberg J, Davis EE, Sunyaev SR, Katsanis N. Identification of cis-suppression of human disease mutations by comparative genomics. Nature. 524: 225-9. PMID 26123021 DOI: 10.1038/Nature14497  0.475
2015 Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, ... ... Sunyaev SR, et al. Genome-wide patterns and properties of de novo mutations in humans. Nature Genetics. PMID 25985141 DOI: 10.1038/Ng.3292  0.388
2015 Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, ... ... Sunyaev S, et al. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 161: 647-60. PMID 25910212 DOI: 10.1016/J.Cell.2015.04.013  0.403
2015 Polak P, Karli? R, Koren A, Thurman R, Sandstrom R, Lawrence MS, Reynolds A, Rynes E, Vlahovi?ek K, Stamatoyannopoulos JA, Sunyaev SR. Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature. 518: 360-4. PMID 25693567 DOI: 10.1038/Nature14221  0.327
2015 Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, ... ... Sunyaev S, et al. Integrative analysis of 111 reference human epigenomes. Nature. 518: 317-30. PMID 25693563 DOI: 10.1038/Nature14248  0.424
2015 Do R, Balick D, Li H, Adzhubei I, Sunyaev S, Reich D. No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans. Nature Genetics. 47: 126-31. PMID 25581429 DOI: 10.1038/Ng.3186  0.777
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Sunyaev SR, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/Nature13917  0.35
2014 Francioli LC, Menelaou A, Pulit SL, Van Dijk F, Palamara PF, Elbers CC, Neerincx PBT, Ye K, Guryev V, Kloosterman WP, Deelen P, Abdellaoui A, Van Leeuwen EM, Van Oven M, Vermaat M, ... ... Sunyaev SR, et al. Whole-genome sequence variation, population structure and demographic history of the Dutch population Nature Genetics. 46: 818-825. PMID 24974849 DOI: 10.1038/Ng.3021  0.457
2014 MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, ... ... Sunyaev SR, et al. Guidelines for investigating causality of sequence variants in human disease. Nature. 508: 469-76. PMID 24759409 DOI: 10.1038/Nature13127  0.452
2014 Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, ... ... Sunyaev SR, et al. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology. 15: R53. PMID 24667040 DOI: 10.1186/Gb-2014-15-3-R53  0.395
2014 Stanley CM, Sunyaev SR, Greenblatt MS, Oetting WS. Clinically relevant variants - identifying, collecting, interpreting, and disseminating: the 2013 annual scientific meeting of the Human Genome Variation Society. Human Mutation. 35: 505-10. PMID 24470180 DOI: 10.1002/Humu.22516  0.413
2014 Zuk O, Schaffner SF, Samocha K, Do R, Hechter E, Kathiresan S, Daly MJ, Neale BM, Sunyaev SR, Lander ES. Searching for missing heritability: designing rare variant association studies. Proceedings of the National Academy of Sciences of the United States of America. 111: E455-64. PMID 24443550 DOI: 10.1073/Pnas.1322563111  0.477
2014 Polak P, Lawrence MS, Haugen E, Stoletzki N, Stojanov P, Thurman RE, Garraway LA, Mirkin S, Getz G, Stamatoyannopoulos JA, Sunyaev SR. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nature Biotechnology. 32: 71-5. PMID 24336318 DOI: 10.1038/Nbt.2778  0.325
2013 Sunagawa S, Schloissnig S, Arumugam M, Forslund K, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Typas A, Weinstock GM, et al. Individuality and temporal stability of the human gut microbiome. Central Asian Journal of Global Health. 2: 120. PMID 29805877 DOI: 10.5195/Cajgh.2013.120  0.754
2013 Sunyaev SR, Roth FP. Systems biology and the analysis of genetic variation. Current Opinion in Genetics & Development. 23: 599-601. PMID 24291212 DOI: 10.1016/J.Gde.2013.11.010  0.518
2013 Agarwala V, Flannick J, Sunyaev S, Altshuler D. Evaluating empirical bounds on complex disease genetic architecture. Nature Genetics. 45: 1418-27. PMID 24141362 DOI: 10.1038/Ng.2804  0.436
2013 Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, ... ... Sunyaev S, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 499: 214-8. PMID 23770567 DOI: 10.1038/Nature12213  0.385
2013 Goldstein DB, Allen A, Keebler J, Margulies EH, Petrou S, Petrovski S, Sunyaev S. Sequencing studies in human genetics: design and interpretation. Nature Reviews. Genetics. 14: 460-70. PMID 23752795 DOI: 10.1038/Nrg3455  0.45
2013 Gokcumen O, Zhu Q, Mulder LC, Iskow RC, Austermann C, Scharer CD, Raj T, Boss JM, Sunyaev S, Price A, Stranger B, Simon V, Lee C. Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence. Plos Genetics. 9: e1003404. PMID 23593015 DOI: 10.1371/Journal.Pgen.1003404  0.518
2013 Kiezun A, Pulit SL, Francioli LC, van Dijk F, Swertz M, Boomsma DI, van Duijn CM, Slagboom PE, van Ommen GJ, Wijmenga C, de Bakker PI, Sunyaev SR. Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. Plos Genetics. 9: e1003301. PMID 23468643 DOI: 10.1371/Journal.Pgen.1003301  0.482
2013 McFarland CD, Korolev KS, Kryukov GV, Sunyaev SR, Mirny LA. Impact of deleterious passenger mutations on cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 110: 2910-5. PMID 23388632 DOI: 10.1073/Pnas.1213968110  0.333
2013 Adzhubei I, Jordan DM, Sunyaev SR. Predicting functional effect of human missense mutations using PolyPhen-2. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit7.20. PMID 23315928 DOI: 10.1002/0471142905.Hg0720S76  0.476
2013 Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, ... ... Sunyaev S, et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. American Journal of Human Genetics. 92: 15-27. PMID 23261300 DOI: 10.1016/J.Ajhg.2012.11.012  0.352
2013 Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A, Waller A, Mende DR, Kultima JR, Martin J, Kota K, Sunyaev SR, Weinstock GM, Bork P. Genomic variation landscape of the human gut microbiome. Nature. 493: 45-50. PMID 23222524 DOI: 10.1038/Nature11711  0.778
2013 Thompson BA, Greenblatt MS, Vallee MP, Herkert JC, Tessereau C, Young EL, Adzhubey IA, Li B, Bell R, Feng B, Mooney SD, Radivojac P, Sunyaev SR, Frebourg T, Hofstra RM, et al. Calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions. Human Mutation. 34: 255-65. PMID 22949387 DOI: 10.1002/Humu.22214  0.397
2012 Koren A, Polak P, Nemesh J, Michaelson JJ, Sebat J, Sunyaev SR, McCarroll SA. Differential relationship of DNA replication timing to different forms of human mutation and variation. American Journal of Human Genetics. 91: 1033-40. PMID 23176822 DOI: 10.1016/J.Ajhg.2012.10.018  0.376
2012 Nusinow DP, Kiezun A, O'Connell DJ, Chick JM, Yue Y, Maas RL, Gygi SP, Sunyaev SR. Network-based inference from complex proteomic mixtures using SNIPE. Bioinformatics (Oxford, England). 28: 3115-22. PMID 23060611 DOI: 10.1093/Bioinformatics/Bts594  0.784
2012 Sunyaev SR. Inferring causality and functional significance of human coding DNA variants. Human Molecular Genetics. 21: R10-7. PMID 22990389 DOI: 10.1093/Hmg/Dds385  0.468
2012 Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, Shafer A, Neri F, Lee K, Kutyavin T, Stehling-Sun S, ... ... Sunyaev SR, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science (New York, N.Y.). 337: 1190-5. PMID 22955828 DOI: 10.1126/Science.1222794  0.409
2012 Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, ... ... Sunyaev SR, et al. The accessible chromatin landscape of the human genome. Nature. 489: 75-82. PMID 22955617 DOI: 10.1038/Nature11232  0.356
2012 Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, ... ... Sunyaev SR, et al. Exome sequencing and the genetic basis of complex traits. Nature Genetics. 44: 623-30. PMID 22641211 DOI: 10.1038/Ng.2303  0.423
2012 Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, ... ... Sunyaev S, et al. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nature Genetics. 44: 631-5. PMID 22610117 DOI: 10.1038/Ng.2283  0.423
2012 Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, ... ... Sunyaev S, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.). 337: 64-9. PMID 22604720 DOI: 10.1126/Science.1219240  0.506
2012 Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, ... ... Sunyaev SR, et al. Mutation mapping and identification by whole-genome sequencing. Genome Research. 22: 1541-8. PMID 22555591 DOI: 10.1101/Gr.135541.111  0.411
2012 Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, ... ... Sunyaev S, et al. The interface of protein structure, protein biophysics, and molecular evolution. Protein Science : a Publication of the Protein Society. 21: 769-85. PMID 22528593 DOI: 10.1002/Pro.2071  0.377
2012 Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A, Lin CF, Stevens C, Wang LS, Makarov V, Polak P, Yoon S, Maguire J, Crawford EL, Campbell NG, ... ... Sunyaev S, et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature. 485: 242-5. PMID 22495311 DOI: 10.1038/Nature11011  0.397
2012 Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America. 109: 1193-8. PMID 22223662 DOI: 10.1073/Pnas.1119675109  0.403
2012 Du R, Litonjua AA, Tantisira KG, Lasky-Su J, Sunyaev SR, Klanderman BJ, Celedón JC, Avila L, Soto-Quiros ME, Weiss ST. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. The Journal of Allergy and Clinical Immunology. 129: 368-73, 373.e1-5. PMID 22051697 DOI: 10.1016/J.Jaci.2011.09.034  0.307
2011 Stitziel NO, Kiezun A, Sunyaev S. Computational and statistical approaches to analyzing variants identified by exome sequencing Genome Biology. 12. PMID 21920052 DOI: 10.1186/Gb-2011-12-9-227  0.364
2011 Spirin V, Shpunt A, Seebacher J, Gentzel M, Shevchenko A, Gygi S, Sunyaev S. Assigning spectrum-specific P-values to protein identifications by mass spectrometry. Bioinformatics (Oxford, England). 27: 1128-34. PMID 21349864 DOI: 10.1093/bioinformatics/btr089  0.381
2011 Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, Sunyaev SR. Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. American Journal of Human Genetics. 88: 183-92. PMID 21310275 DOI: 10.1016/J.Ajhg.2011.01.011  0.391
2011 Spirin V, Shpunt A, Seebacher J, Gentzel M, Shevchenko A, Gygi S, Sunyaev S. Assigning spectrum-specific P-values to protein identifications by mass spectrometry Bioinformatics. 27: 1128-1134. DOI: 10.1093/Bioinformatics/Btr089  0.47
2010 Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ, Sunyaev SR. Pooled association tests for rare variants in exon-resequencing studies. American Journal of Human Genetics. 86: 832-8. PMID 20471002 DOI: 10.1016/J.Ajhg.2010.05.014  0.462
2010 Jordan DM, Ramensky VE, Sunyaev SR. Human allelic variation: perspective from protein function, structure, and evolution. Current Opinion in Structural Biology. 20: 342-50. PMID 20399638 DOI: 10.1016/J.Sbi.2010.03.006  0.529
2010 Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations. Nature Methods. 7: 248-9. PMID 20354512 DOI: 10.1038/Nmeth0410-248  0.587
2009 Molla M, Delcher A, Sunyaev S, Cantor C, Kasif S. Triplet repeat length bias and variation in the human transcriptome Proceedings of the National Academy of Sciences of the United States of America. 106: 17095-17100. PMID 19805156 DOI: 10.1073/Pnas.0907112106  0.47
2009 Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM. Multiplex padlock targeted sequencing reveals human hypermutable CpG variations. Genome Research. 19: 1606-15. PMID 19525355 DOI: 10.1101/Gr.092213.109  0.435
2009 Stamatoyannopoulos JA, Adzhubei I, Thurman RE, Kryukov GV, Mirkin SM, Sunyaev SR. Human mutation rate associated with DNA replication timing. Nature Genetics. 41: 393-5. PMID 19287383 DOI: 10.1038/Ng.363  0.361
2009 Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR. Power of deep, all-exon resequencing for discovery of human trait genes. Proceedings of the National Academy of Sciences of the United States of America. 106: 3871-6. PMID 19202052 DOI: 10.1073/Pnas.0812824106  0.485
2009 Sunyaev SR, Lugovskoy A, Simon K, Gorelik L. Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). Plos Genetics. 5: e1000368. PMID 19197354 DOI: 10.1371/Journal.Pgen.1000368  0.324
2008 Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S. Hypermutable non-synonymous sites are under stronger negative selection. Plos Genetics. 4: e1000281. PMID 19043566 DOI: 10.1371/Journal.Pgen.1000281  0.384
2008 Beckstead WA, Bjork BC, Stottmann RW, Sunyaev S, Beier DR. SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 687-90. PMID 18958524 DOI: 10.1007/S00335-008-9149-2  0.395
2008 Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A. Protein identification pipeline for the homology-driven proteomics Journal of Proteomics. 71: 346-356. PMID 18639657 DOI: 10.1016/J.Jprot.2008.07.003  0.303
2008 Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD. Assessing the evolutionary impact of amino acid mutations in the human genome. Plos Genetics. 4: e1000083. PMID 18516229 DOI: 10.1371/Journal.Pgen.1000083  0.503
2008 Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD. Proportionally more deleterious genetic variation in European than in African populations. Nature. 451: 994-7. PMID 18288194 DOI: 10.1038/Nature06611  0.418
2008 Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. American Journal of Human Genetics. 82: 100-12. PMID 18179889 DOI: 10.1016/J.Ajhg.2007.09.006  0.364
2008 Ballif BA, Carey GR, Sunyaev SR, Gygi SP. Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. Journal of Proteome Research. 7: 311-8. PMID 18034455 DOI: 10.1021/Pr0701254  0.411
2007 Asthana S, Roytberg M, Stamatoyannopoulos J, Sunyaev S. Analysis of sequence conservation at nucleotide resolution Plos Computational Biology. 3: e254. PMID 18166073 DOI: 10.1371/Journal.Pcbi.0030254  0.466
2007 Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, Sunyaev SR. Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. American Journal of Human Genetics. 81: 1298-303. PMID 17952847 DOI: 10.1086/522497  0.376
2007 Asthana S, Noble WS, Kryukov G, Grant CE, Sunyaev S, Stamatoyannopoulos JA. Widely distributed noncoding purifying selection in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 104: 12410-5. PMID 17640883 DOI: 10.1073/Pnas.0705140104  0.485
2007 Waridel P, Frank A, Thomas H, Surendranath V, Sunyaev S, Pevzner P, Shevchenko A. Sequence similarity-driven proteomics in organisms with unknown genomes by LC-MS/MS and automated de novo sequencing. Proteomics. 7: 2318-29. PMID 17623296 DOI: 10.1002/Pmic.200700003  0.324
2007 Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, ... ... Sunyaev S, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447: 799-816. PMID 17571346 DOI: 10.1038/Nature05874  0.605
2007 Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, et al. Medical sequencing at the extremes of human body mass. American Journal of Human Genetics. 80: 779-91. PMID 17357083 DOI: 10.1086/513471  0.347
2007 Kryukov GV, Pennacchio LA, Sunyaev SR. Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. American Journal of Human Genetics. 80: 727-39. PMID 17357078 DOI: 10.1086/513473  0.494
2006 Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Koonin EV, Kondrashov AS, Sunyaev S. Protein evolution: Causes of trends in amino-acid gain and loss (Reply) Nature. 442: E12. DOI: 10.1038/Nature05138  0.341
2005 Keightley PD, Kryukov GV, Sunyaev S, Halligan DL, Gaffney DJ. Evolutionary constraints in conserved nongenic sequences of mammals. Genome Research. 15: 1373-8. PMID 16204190 DOI: 10.1101/Gr.3942005  0.501
2005 Kryukov GV, Schmidt S, Sunyaev S. Small fitness effect of mutations in highly conserved non-coding regions. Human Molecular Genetics. 14: 2221-9. PMID 15994173 DOI: 10.1093/Hmg/Ddi226  0.411
2005 Asthana S, Schmidt S, Sunyaev S. A limited role for balancing selection Trends in Genetics. 21: 30-32. PMID 15680511 DOI: 10.1016/J.Tig.2004.11.001  0.439
2004 Liska AJ, Popov AV, Sunyaev S, Coughlin P, Habermann B, Shevchenko A, Bork P, Karsenti E, Shevchenko A. Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome. Proteomics. 4: 2707-21. PMID 15352245 DOI: 10.1002/Pmic.200300813  0.496
2004 Ogurtsov AY, Sunyaev S, Kondrashov AS. Indel-based evolutionary distance and mouse-human divergence. Genome Research. 14: 1610-6. PMID 15289479 DOI: 10.1101/Gr.2450504  0.393
2004 Bazykin GA, Kondrashov FA, Ogurtsov AY, Sunyaev S, Kondrashov AS. Positive selection at sites of multiple amino acid replacements since rat-mouse divergence. Nature. 429: 558-62. PMID 15175752 DOI: 10.1038/Nature02601  0.373
2004 Sunyaev SR, Bogopolsky GA, Oleynikova NV, Vlasov PK, Finkelstein AV, Roytberg MA. From analysis of protein structural alignments toward a novel approach to align protein sequences. Proteins. 54: 569-82. PMID 14748004 DOI: 10.1002/Prot.10503  0.324
2004 Habermann B, Oegema J, Sunyaev S, Shevchenko A. The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searches Molecular and Cellular Proteomics. 3: 238-249. PMID 14695901 DOI: 10.1074/Mcp.M300073-Mcp200  0.351
2003 Sunyaev S, Kondrashov FA, Bork P, Ramensky V. Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics. 12: 3325-30. PMID 14570704 DOI: 10.1093/Hmg/Ddg359  0.637
2003 Schmidt S, Sunyaev S, Bork P, Dandekar T. Metabolites: a helping hand for pathway evolution? Trends in Biochemical Sciences. 28: 336-41. PMID 12826406 DOI: 10.1016/S0968-0004(03)00114-2  0.548
2003 Sunyaev S, Liska AJ, Golod A, Shevchenko A. MultiTag: Multiple error-tolerant sequence tag search for the sequence-similarity identification of proteins by mass spectrometry Analytical Chemistry. 75: 1307-1315. PMID 12659190 DOI: 10.1021/Ac026199A  0.347
2003 Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S. Increase of functional diversity by alternative splicing. Trends in Genetics : Tig. 19: 124-8. PMID 12615003 DOI: 10.1016/S0168-9525(03)00023-4  0.464
2003 Shevchenko A, Sunyaev S, Liska A, Bork P, Shevchenko A. Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes. Methods in Molecular Biology (Clifton, N.J.). 211: 221-34. PMID 12489434 DOI: 10.1385/1-59259-342-9:221  0.503
2002 Kondrashov AS, Sunyaev S, Kondrashov FA. Dobzhansky-Muller incompatibilities in protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 99: 14878-83. PMID 12403824 DOI: 10.1073/Pnas.232565499  0.398
2002 Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Research. 30: 3894-900. PMID 12202775 DOI: 10.1093/Nar/Gkf493  0.591
2001 Shevchenko A, Sunyaev S, Loboda A, Shevchenko A, Bork P, Ens W, Standing KG. Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching. Analytical Chemistry. 73: 1917-26. PMID 11354471 DOI: 10.1021/AC0013709  0.395
2001 Sunyaev S, Ramensky V, Koch I, Lathe W, Kondrashov AS, Bork P. Prediction of deleterious human alleles. Human Molecular Genetics. 10: 591-7. PMID 11230178 DOI: 10.1093/Hmg/10.6.591  0.801
2001 Sunyaev S, Lathe W, Bork P. Integration of genome data and protein structures: prediction of protein folds, protein interactions and "molecular phenotypes" of single nucleotide polymorphisms. Current Opinion in Structural Biology. 11: 125-30. PMID 11179902 DOI: 10.1016/S0959-440X(00)00175-5  0.802
2000 Sunyaev SR, Lathe WC, Ramensky VE, Bork P. SNP frequencies in human genes an excess of rare alleles and differing modes of selection. Trends in Genetics : Tig. 16: 335-7. PMID 10904261 DOI: 10.1016/S0168-9525(00)02058-8  0.789
2000 Sunyaev S, Hanke J, Brett D, Aydin A, Zastrow I, Lathe W, Bork P, Reich J. Individual variation in protein-coding sequences of human genome. Advances in Protein Chemistry. 54: 409-37. PMID 10829234 DOI: 10.1016/S0065-3233(00)54012-1  0.801
2000 Sunyaev S, Ramensky V, Bork P. Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends in Genetics : Tig. 16: 198-200. PMID 10782110 DOI: 10.1016/S0168-9525(00)01988-0  0.506
1999 Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P. Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes. Journal of Molecular Medicine (Berlin, Germany). 77: 754-60. PMID 10619435 DOI: 10.1007/S001099900059  0.706
1999 Sunyaev SR, Eisenhaber F, Rodchenkov IV, Eisenhaber B, Tumanyan VG, Kuznetsov EN. PSIC: profile extraction from sequence alignments with position-specific counts of independent observations. Protein Engineering. 12: 387-94. PMID 10360979 DOI: 10.1093/Protein/12.5.387  0.324
1998 Huynen M, Doerks T, Eisenhaber F, Orengo C, Sunyaev S, Yuan Y, Bork P. Homology-based fold predictions for Mycoplasma genitalium proteins. Journal of Molecular Biology. 280: 323-6. PMID 9665839 DOI: 10.1006/Jmbi.1998.1884  0.758
1997 Sunyaev S, Kuznetsov E, Rodchenkov I, Tumanyan V. Protein sequence-structure compatibility criteria in terms of statistical hypothesis testing. Protein Engineering. 10: 635-46. PMID 9278276 DOI: 10.1093/Protein/10.6.635  0.351
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