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Year Citation  Score
2015 Khanna MR, Fortini ME. Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-β Precursor-Like Protein Activity. Journal of Alzheimer's Disease : Jad. 46: 913-28. PMID 26402626 DOI: 10.3233/JAD-141491  1
2013 Sasamura T, Matsuno K, Fortini ME. Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling. Plos Genetics. 9: e1003917. PMID 24244188 DOI: 10.1371/journal.pgen.1003917  1
2013 Groth C, Sasamura T, Khanna MR, Whitley M, Fortini ME. Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup. Development (Cambridge, England). 140: 3018-27. PMID 23785054 DOI: 10.1242/dev.088336  1
2013 Yousefian J, Troost T, Grawe F, Sasamura T, Fortini M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. Journal of Cell Science. 126: 1583-94. PMID 23418349 DOI: 10.1242/jcs.114934  1
2012 Fortini ME. Introduction--Notch in development and disease. Seminars in Cell & Developmental Biology. 23: 419-20. PMID 22425963 DOI: 10.1016/j.semcdb.2012.03.001  1
2012 Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Seminars in Cell & Developmental Biology. 23: 465-72. PMID 22309842 DOI: 10.1016/j.semcdb.2012.01.016  1
2012 Yamakawa T, Yamada K, Sasamura T, Nakazawa N, Kanai M, Suzuki E, Fortini ME, Matsuno K. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila. Development (Cambridge, England). 139: 558-67. PMID 22190636 DOI: 10.1242/dev.073858  1
2010 McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, ... ... Fortini ME, et al. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9510-22. PMID 20631179 DOI: 10.1523/JNEUROSCI.1017-10.2010  1
2010 Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Molecular and Cellular Biology. 30: 3165-75. PMID 20421416 DOI: 10.1128/MCB.00030-10  1
2010 Groth C, Alvord WG, Quiñones OA, Fortini ME. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Molecular Pharmacology. 77: 567-74. PMID 20064975 DOI: 10.1124/mol.109.062471  1
2009 Cuc HT, Seo JB, Choi JK, Kim WT, Park SJ, Lee DW, Kim YS, Fortini ME, Koh YH. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin. Hybridoma (2005). 28: 215-20. PMID 19519249 DOI: 10.1089/hyb.2008.0086  1
2009 Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Developmental Cell. 16: 633-47. PMID 19460341 DOI: 10.1016/j.devcel.2009.03.010  1
2009 Fortini ME, Bilder D. Endocytic regulation of Notch signaling. Current Opinion in Genetics & Development. 19: 323-8. PMID 19447603 DOI: 10.1016/j.gde.2009.04.005  1
2009 Diwan BA, Timofeeva O, Rice JM, Yang Y, Sharma N, Fortini ME, Wang H, Perantoni AO. Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. Differentiation; Research in Biological Diversity. 77: 424-32. PMID 19281789 DOI: 10.1016/j.diff.2008.12.003  1
2008 Kanwar R, Fortini ME. The big brain aquaporin is required for endosome maturation and notch receptor trafficking. Cell. 133: 852-63. PMID 18510929 DOI: 10.1016/j.cell.2008.04.038  1
2008 Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. The Journal of Cell Biology. 180: 755-62. PMID 18299346 DOI: 10.1083/jcb.200708127  1
2007 Tountas NA, Fortini ME. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006. Fly. 1: 47-54. PMID 18690062  1
2007 Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini ME, Zhong Y, Xie Z. A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2368-78. PMID 17428965 DOI: 10.1096/fj.06-6380com  1
2007 Fortini ME. Medicine. Anticipating trouble from gene transcription. Science (New York, N.Y.). 315: 1800-1. PMID 17395816 DOI: 10.1126/science.1141279  1
2006 Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Current Biology : Cb. 16: 1026-33. PMID 16713961 DOI: 10.1016/j.cub.2006.04.004  1
2006 Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 50: 359-75. PMID 16675392 DOI: 10.1016/j.neuron.2006.03.038  1
2004 Kanwar R, Fortini ME. Notch signaling: a different sort makes the cut. Current Biology : Cb. 14: R1043-5. PMID 15620635 DOI: 10.1016/j.cub.2004.11.041  1
2004 Periz G, Fortini ME. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. Journal of Neuroscience Research. 77: 309-22. PMID 15248287 DOI: 10.1002/jnr.20203  1
2004 Fortini ME. PAR-1 for the course of neurodegeneration. Cell. 116: 631-2. PMID 15006343 DOI: 10.1016/S0092-8674(04)00207-7  1
2003 Fortini ME. Neurobiology: double trouble for neurons. Nature. 425: 565-6. PMID 14534567 DOI: 10.1038/425565a  1
2003 Hu Y, Fortini ME. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. The Journal of Cell Biology. 161: 685-90. PMID 12771124 DOI: 10.1083/jcb.200304014  1
2003 Bonini NM, Fortini ME. Human neurodegenerative disease modeling using Drosophila. Annual Review of Neuroscience. 26: 627-56. PMID 12704223 DOI: 10.1146/annurev.neuro.26.041002.131425  1
2002 Bonini NM, Fortini ME. Applications of the Drosophila retina to human disease modeling. Results and Problems in Cell Differentiation. 37: 257-75. PMID 25707079  1
2002 Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nature Reviews. Molecular Cell Biology. 3: 673-84. PMID 12209127 DOI: 10.1038/nrm910  1
2002 Hu Y, Ye Y, Fortini ME. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Developmental Cell. 2: 69-78. PMID 11782315 DOI: 10.1016/S1534-5807(01)00105-8  1
2001 Fortini ME. Sugar-coated pathways for developmental patterning. Nature Cell Biology. 3: E229-31. PMID 11584283 DOI: 10.1038/ncb1001-e229  1
2001 Heidary G, Fortini ME. Identification and characterization of the Drosophila tau homolog. Mechanisms of Development. 108: 171-8. PMID 11578871 DOI: 10.1016/S0925-4773(01)00487-7  1
2001 Fortini ME. Notch and presenilin: a proteolytic mechanism emerges. Current Opinion in Cell Biology. 13: 627-34. PMID 11544033 DOI: 10.1016/S0955-0674(00)00261-1  1
2000 Periz G, Fortini ME. Proteolysis in Alzheimer's disease. Can plasmin tip the balance? Embo Reports. 1: 477-8. PMID 11263489 DOI: 10.1093/embo-reports/kvd124  1
2000 Fortini ME. Fringe benefits to carbohydrates. Nature. 406: 357-8. PMID 10935619 DOI: 10.1038/35019233  1
2000 Fortini ME, Skupski MP, Boguski MS, Hariharan IK. A survey of human disease gene counterparts in the Drosophila genome. The Journal of Cell Biology. 150: F23-30. PMID 10908582  1
2000 Ye Y, Fortini ME. Proteolysis and developmental signal transduction. Seminars in Cell & Developmental Biology. 11: 211-21. PMID 10906278 DOI: 10.1006/scdb.2000.0167  1
2000 Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, et al. Comparative genomics of the eukaryotes. Science (New York, N.Y.). 287: 2204-15. PMID 10731134 DOI: 10.1126/science.287.5461.2204  1
2000 Fortini ME, Bonini NM. Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends in Genetics : Tig. 16: 161-7. PMID 10729831 DOI: 10.1016/S0168-9525(99)01939-3  1
1999 Lukinova NI, Roussakova VV, Fortini ME. Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster. Genetics. 153: 1789-97. PMID 10581285  1
1999 Bonini NM, Fortini ME. Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 991-1003. PMID 10580984 DOI: 10.1002/(SICI)1521-1878(199912)22:1<991::AID-BIES3>3.0.CO;2-3  1
1999 Wu Z, Li Q, Fortini ME, Fischer JA. Genetic analysis of the role of the drosophila fat facets gene in the ubiquitin pathway. Developmental Genetics. 25: 312-20. PMID 10570463 DOI: 10.1002/(SICI)1520-6408(1999)25:4<312::AID-DVG5>3.0.CO;2-Z  1
1999 Periz G, Fortini ME. Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila. The Embo Journal. 18: 5983-93. PMID 10545110 DOI: 10.1093/emboj/18.21.5983  1
1999 Ye Y, Fortini ME. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. The Journal of Cell Biology. 146: 1351-64. PMID 10491396 DOI: 10.1083/jcb.146.6.1351  1
1999 Ye Y, Lukinova N, Fortini ME. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 398: 525-9. PMID 10206647 DOI: 10.1038/19096  1
1998 Ye Y, Fortini ME. Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mechanisms of Development. 79: 199-211. PMID 10349633 DOI: 10.1016/S0925-4773(98)00169-5  1
1996 Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S. Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics. 144: 1127-41. PMID 8913755  1
1995 Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science (New York, N.Y.). 268: 225-32. PMID 7716513  1
1994 Fortini ME, Artavanis-Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell. 79: 273-82. PMID 7954795 DOI: 10.1016/0092-8674(94)90196-1  1
1993 Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 365: 555-7. PMID 8413612 DOI: 10.1038/365555a0  1
1993 Fortini ME, Artavanis-Tsakonas S. Notch: neurogenesis is only part of the picture. Cell. 75: 1245-7. PMID 8269507 DOI: 10.1016/0092-8674(93)90611-S  1
1993 Rebay I, Fortini ME, Artavanis-Tsakonas S. Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development. Comptes Rendus De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 316: 1097-123. PMID 8076207  1
1992 Simon MA, Carthew RW, Fortini ME, Gaul U, Mardon G, Rubin GM. Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor. Cold Spring Harbor Symposia On Quantitative Biology. 57: 375-80. PMID 1339672  1
1992 Fortini ME, Simon MA, Rubin GM. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature. 355: 559-61. PMID 1311054 DOI: 10.1038/355559a0  1
1991 Fortini ME, Rubin GM. The optic lobe projection pattern of polarization-sensitive photoreceptor cells in Drosophila melanogaster. Cell and Tissue Research. 265: 185-91. PMID 1913776 DOI: 10.1007/BF00318153  1
1991 Lai ZC, Fortini ME, Rubin GM. The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. Mechanisms of Development. 34: 123-34. PMID 1680377 DOI: 10.1016/0925-4773(91)90049-C  1
1991 Fortini ME, Lai ZC, Rubin GM. The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Mechanisms of Development. 34: 113-22. PMID 1680376 DOI: 10.1016/0925-4773(91)90048-B  1
1990 Fortini ME, Rubin GM. Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster. Genes & Development. 4: 444-63. PMID 2140105  1
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