Nir Hacohen - Publications

Affiliations: 
Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Area:
Virology Biology, Immunology, Cell Biology

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Year Citation  Score
2023 Cui A, Huang T, Li S, Ma A, Pérez JL, Sander C, Keskin DB, Wu CJ, Fraenkel E, Hacohen N. Dictionary of immune responses to cytokines at single-cell resolution. Nature. PMID 38057668 DOI: 10.1038/s41586-023-06816-9  0.305
2023 Reyes M, Leff SM, Gentili M, Hacohen N, Blainey PC. Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands. Science Advances. 9: eade5090. PMID 36827376 DOI: 10.1126/sciadv.ade5090  0.305
2023 Gentili M, Liu B, Papanastasiou M, Dele-Oni D, Schwartz MA, Carlson RJ, Al'Khafaji AM, Krug K, Brown A, Doench JG, Carr SA, Hacohen N. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature Communications. 14: 611. PMID 36739287 DOI: 10.1038/s41467-023-36132-9  0.305
2022 Chao S, Brenner MP, Hacohen N. Identifying Cell Type-Specific Chemokine Correlates with Hierarchical Signal Extraction from Single-Cell Transcriptomes. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 27: 254-265. PMID 34890154  0.3
2021 Chen J, Pelka K, Hofree M, Giannakis M, Boland G, Aguirre A, Anderson A, Rozenblatt-Rosen O, Regev A, Hacohen N. 641 Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer Journal For Immunotherapy of Cancer. 9: A670-A670. DOI: 10.1136/jitc-2021-sitc2021.641  0.301
2020 Chia BS, Li B, Cui A, Eisenhaure T, Raychowdhury R, Lieb D, Hacohen N. Loss of the nuclear protein RTF2 enhances influenza replication. Journal of Virology. PMID 32878895 DOI: 10.1128/Jvi.00319-20  0.349
2020 Johnstone SE, Reyes A, Qi Y, Adriaens C, Hegazi E, Pelka K, Chen JH, Zou LS, Drier Y, Hecht V, Shoresh N, Selig MK, Lareau CA, Iyer S, Nguyen SC, ... ... Hacohen N, et al. Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. PMID 32841603 DOI: 10.1016/J.Cell.2020.07.030  0.332
2020 Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, ... Hacohen N, et al. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nature Biotechnology. PMID 32788668 DOI: 10.1038/S41587-020-0645-6  0.366
2020 Li B, Gould J, Yang Y, Sarkizova S, Tabaka M, Ashenberg O, Rosen Y, Slyper M, Kowalczyk MS, Villani AC, Tickle T, Hacohen N, Rozenblatt-Rosen O, Regev A. Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq. Nature Methods. PMID 32719530 DOI: 10.1038/S41592-020-0905-X  0.335
2020 Marigo I, Trovato R, Hofer F, Ingangi V, DE Sanctis F, Ugel S, Cane S, Simonelli A, Lamolinara A, Iezzi M, Fassan M, Rugge M, Boschi F, Borile G, Eisenhaure T, ... ... Hacohen N, et al. The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages. Cancer Discovery. PMID 32651166 DOI: 10.1158/2159-8290.Cd-20-0036  0.308
2020 de Boer CG, Ray JP, Hacohen N, Regev A. MAUDE: inferring expression changes in sorting-based CRISPR screens. Genome Biology. 21: 134. PMID 32493396 DOI: 10.1186/S13059-020-02046-8  0.332
2020 Fava A, Buyon JP, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine DM, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, ... ... Hacohen N, et al. Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis. Jci Insight. PMID 32396533 DOI: 10.1172/Jci.Insight.138345  0.372
2020 Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, ... ... Hacohen N, et al. Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology. PMID 32341560 DOI: 10.1038/S41587-020-0465-8  0.328
2020 Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, ... Hacohen N, et al. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Nature Communications. 11: 1237. PMID 32144282 DOI: 10.1038/S41467-020-15022-4  0.3
2020 Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, Eisenhaure T, Henrickson SE, Villani AC, Hacohen N, Abudi N, Abramovich R, Cohen JE, Peretz T, Veillette A, et al. SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a novel T cell checkpoint. Elife. 9. PMID 32122464 DOI: 10.7554/Elife.52539  0.365
2020 Menon R, Otto EA, Hoover PJ, Eddy S, Mariani LH, Godfrey B, Berthier CC, Eichinger F, Subramanian L, Harder JL, Ju W, Nair V, Larkina M, Naik AS, Luo J, ... ... Hacohen N, et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. Jci Insight. PMID 32107344 DOI: 10.1172/Jci.Insight.133267  0.378
2020 Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. An immune-cell signature of bacterial sepsis. Nature Medicine. PMID 32066974 DOI: 10.1038/S41591-020-0752-4  0.429
2020 Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, ... ... Hacohen N, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. PMID 31942075 DOI: 10.1038/S41586-019-1922-8  0.419
2020 Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, ... ... Hacohen N, et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nature Communications. 11: 164. PMID 31919360 DOI: 10.1038/S41467-019-13965-X  0.321
2020 Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, David IB, Eisenhaure T, Henrickson SE, Villani AC, Hacohen N, Abudi N, Abramovich R, Cohen JE, Peretz T, Veillette A, et al. Author response: SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint Elife. DOI: 10.7554/Elife.52539.Sa2  0.347
2020 Blum SM, Smith N, Sade-Feldman M, Frederick DT, Jenkins RW, Cohen JV, Lawrence DP, Mooradian M, Freedman C, Fadden R, Rubin KM, Richey S, Flaherty K, Wargo JA, Hacohen N, et al. Investigating the tumor immune infiltrate for populations that predict immune-related adverse events (irAEs) in patients receiving PD-1 inhibitors. Journal of Clinical Oncology. 38: 3116-3116. DOI: 10.1200/Jco.2020.38.15_Suppl.3116  0.301
2020 Mehta A, Rucevic M, Sprecher E, Rosenberg LH, Lieb D, Kasumova GG, Kim MS, Bai X, Frederick DT, Flaherty K, Sullivan RJ, Hacohen N, Boland GM. The use of plasma proteomic markers to understand the biology of immunotherapy response. Journal of Clinical Oncology. 38: 10062-10062. DOI: 10.1200/Jco.2020.38.15_Suppl.10062  0.323
2020 Mehta A, Rucevic M, Sprecher E, Rosenberg LH, Lieb D, Kasumova G, Kim MS, Bai X, Frederick DT, Flaherty K, Sullivan RJ, Hacohen N, Boland G. Abstract LB-260: The use of blood-based protein biomarkers to uncover determinants of immunotherapy response in melanoma Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Lb-260  0.363
2020 Freeman SS, Sade-Feldman M, Kim J, Stewart C, Ravi A, Arniella M, Yizhak K, Leshchiner I, Elagina L, Spiro O, Livitz D, Rosebrock D, Aguet F, Carrot-Zhang J, Gonye A, ... ... Hacohen N, et al. Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma Immunology. 80: 6670-6670. DOI: 10.1158/1538-7445.Am2020-6670  0.361
2020 Hong X, Roh W, Sullivan RJ, Wong KH, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley BK, Boland GM, Marvin DL, Bonesteel T, Lu C, Horwitz E, Aguet F, ... ... Hacohen N, et al. Abstract 6073: The lipogenic regulatorSREBPinducesTransferrinin circulating melanoma cells, suppressing their susceptibility to ferroptosis Tumor Biology. DOI: 10.1158/1538-7445.Am2020-6073  0.342
2020 Arniella M, Ravi A, Stewart C, Freeman S, Awad M, Forde P, Anagnostou V, Henick B, Riess J, Gibbons D, Pennell N, Velcheti V, Leshchiner I, Kim J, Digumarthy S, ... ... Hacohen N, et al. Abstract 5902: Integrative genomic analysis of checkpoint blockade in lung cancer: A multi-institution SU2C collaborative Cancer Research. 80: 5902-5902. DOI: 10.1158/1538-7445.Am2020-5902  0.352
2020 Thomas M, Slowikowski K, Marc S, Nasrallah M, Manakongtreecheep K, Jessica T, Leyre Z, Misdraji J, Reynolds K, Hacohen N, Villani A. 1091 SINGLE CELL IMMUNOLOGIC DISSECTION OF HEPATITIS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY REVEALS INSIGHTS INTO IMMUNE TOLERANCE IN THE HUMAN LIVER Gastroenterology. 158: S-1305. DOI: 10.1016/S0016-5085(20)33924-X  0.32
2020 Thomas M, Slowikowski K, Nasrallah M, Manakongtreecheep K, Jessica T, Leyre Z, Khalili H, Reynolds K, Dougan M, Hacohen N, Villani A. 318 SINGLE CELL DISSECTION OF THE TRANSCRIPTIONAL LANDSCAPE DEFINING CHECKPOINT INHIBITOR-ASSOCIATED COLITIS OPENS A WINDOW INTO IMMUNE DYSREGULATION IN THE HUMAN COLON Gastroenterology. 158: S-57. DOI: 10.1016/S0016-5085(20)30825-8  0.384
2019 Chapuy L, Bsat M, Sarkizova S, Rubio M, Therrien A, Wassef E, Bouin M, Orlicka K, Weber A, Hacohen N, Villani AC, Sarfati M. Correction: Two distinct colonic CD14 subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunology. PMID 31819171 DOI: 10.1038/S41385-019-0242-5  0.309
2019 Zhang J, Hu X, Wang J, Sahu AD, Cohen D, Song L, Ouyang Z, Fan J, Wang B, Fu J, Gu S, Sade-Feldman M, Hacohen N, Li W, Ying X, et al. Immune receptor repertoires in pediatric and adult acute myeloid leukemia. Genome Medicine. 11: 73. PMID 31771646 DOI: 10.1186/S13073-019-0681-3  0.362
2019 Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, ... ... Hacohen N, et al. Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. PMID 31409923 DOI: 10.1038/S41590-019-0473-3  0.316
2019 Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, ... ... Hacohen N, et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. PMID 31209404 DOI: 10.1038/S41590-019-0398-X  0.429
2019 Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, et al. Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers. Nature Genetics. PMID 31101897 DOI: 10.1038/S41588-019-0437-4  0.329
2019 Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, ... ... Hacohen N, et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature Immunology. PMID 31061532 DOI: 10.1038/S41590-019-0378-1  0.354
2019 Ludwig LS, Lareau CA, Ulirsch JC, Christian E, Muus C, Li LH, Pelka K, Ge W, Oren Y, Brack A, Law T, Rodman C, Chen JH, Boland GM, Hacohen N, et al. Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics. Cell. PMID 30827679 DOI: 10.1016/J.Cell.2019.01.022  0.367
2019 Myers SA, Rhoads A, Cocco AR, Peckner R, Haber A, Schweitzer LD, Krug K, Mani DR, Clauser KR, Rozenblatt-Rosen O, Hacohen N, Regev A, Carr SA. Streamlined protocol for deep proteomic profiling of FAC-sorted cells and its application to freshly isolated murine immune cells. Molecular & Cellular Proteomics : McP. PMID 30792265 DOI: 10.1074/Mcp.Ra118.001259  0.413
2019 Reyes M, Vickers D, Billman K, Eisenhaure T, Hoover P, Browne EP, Rao DA, Hacohen N, Blainey PC. Multiplexed enrichment and genomic profiling of peripheral blood cells reveal subset-specific immune signatures. Science Advances. 5: eaau9223. PMID 30746468 DOI: 10.1126/Sciadv.Aau9223  0.43
2019 Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, et al. Landscape of B cell immunity and related immune evasion in human cancers. Nature Genetics. PMID 30742113 DOI: 10.1038/S41588-018-0339-X  0.384
2019 Lan YY, Heather JM, Eisenhaure T, Garris CS, Lieb D, Raychowdhury R, Hacohen N. Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation. Aging Cell. e12901. PMID 30706626 DOI: 10.1111/Acel.12901  0.317
2019 Chapuy L, Bsat M, Sarkizova S, Rubio M, Therrien A, Wassef E, Bouin M, Orlicka K, Weber A, Hacohen N, Villani AC, Sarfati M. Two distinct colonic CD14 subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunology. PMID 30670762 DOI: 10.1038/S41385-018-0126-0  0.33
2019 Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, ... ... Hacohen N, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 176: 404. PMID 30633907 DOI: 10.1016/J.Cell.2018.12.034  0.327
2019 Hacohen N. Abstract IA35: Determinants of effective tumor immunity Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia35  0.382
2019 Hu Z, Leet D, Sarkizova S, Holden R, Sun J, Klaeger S, Clauser KR, Shukla SA, Zhang W, Carr SA, Fritsch EF, Pentelute BL, Hacohen N, Keskin DB, Ott PA, et al. Abstract A010: Personalized neoantigen-targeting vaccines for high-risk melanoma generate epitope spreading Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A010  0.32
2019 Mehta A, Kasumova G, Shi A, Rucevic M, Sallman-Almen M, Rosenberg LH, Sprecher E, Ohmura J, Kim M, Lieb D, Bai X, Frederick DT, Kellis M, Sullivan RJ, Flaherty KT, ... Hacohen N, et al. Abstract 4533: Plasma and exosome proteomic profiling for prediction of immunotherapy response and toxicity Cancer Research. 79: 4533-4533. DOI: 10.1158/1538-7445.Sabcs18-4533  0.322
2019 Ouspenskaia T, Law TE, Clauser KR, Klaeger S, Keskin DB, Li B, Christian E, Chow YT, Le PM, Gould J, Ji Z, Zhang W, Bachireddy P, Sarkizova S, Hacohen N, et al. Abstract 566: Neoantigens from translated unannotated open reading frames in cancer Cancer Research. 79: 566-566. DOI: 10.1158/1538-7445.Am2019-566  0.356
2019 Reddy SM, Helmink B, Gao J, Zhang S, Yizhak K, Sade-Feldman M, Basar R, Blando J, Han G, Gopalakrishnan V, Zhao H, Liu W, Tawbi H, Amaria R, Davies M, ... ... Hacohen N, et al. Abstract 4488: Effector B cells and tertiary lymphoid structures predict response to immune checkpoint blockade in solid tumors Cancer Research. 79: 4488-4488. DOI: 10.1158/1538-7445.Am2019-4488  0.399
2019 Mehta A, Liu D, Shi A, Frederick DT, Ho L, Larque AB, Miao B, Raghavan RS, Sharova T, Shin JH, Rinaldi N, Chebib IA, Kellis M, Allen EV, Hacohen N, et al. Abstract 3013: Acquired resistance to immune checkpoint inhibition by melanoma phenotypic transformation Cancer Research. 79: 3013-3013. DOI: 10.1158/1538-7445.Am2019-3013  0.363
2019 Fava A, Zhang Y, Hacohen N, Arazi A, Berthier CC, Rao D, Brenner M, Wofsy D, Davidson A, Kretzler M, Hildeman D, Woodle ES, Diamond B, Petri M. 205 Single cell RNA expression in lupus nephritis comparing african-american and caucasian patients identifies differential expression of type I interferon pathway Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.205  0.422
2019 Berthier CC, Arazi A, Rao D, Davidson A, Browne E, Eisenhaure T, Hacohen N, Lieb DJ, Diamond B, Kretzler M. 204 The immune cell landscape in kidneys of lupus nephritis patients Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.204  0.412
2019 Fava A, Zhang Y, Hacohen N, Arazi A, Berthier C, Rao D, Brenner M, Wofsy D, Davidson A, Kretzler M, Hildeman D, Woodle ES, Diamond B, Petri MA. Ab0167 Single Cell Rna Expression In Lupus Nephritis Comparing African-American And Caucasian Patients Identifies Differential Expression Of Type I Interferon Pathway Annals of the Rheumatic Diseases. 78: 1542-1542. DOI: 10.1136/Annrheumdis-2019-Eular.5673  0.428
2019 Reyes M, Bhattacharyya RP, Filbin M, Billman K, Eisenhaure T, Hung DT, Levy B, Baron R, Blainey P, Goldberg MB, Hacohen N. 1830. Single-cell Transcriptional Profiling Reveals an Immune Cell State Signature of Bacterial Sepsis Open Forum Infectious Diseases. 6: S42-S42. DOI: 10.1093/Ofid/Ofz359.092  0.429
2018 Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, ... ... Hacohen N, et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. PMID 30568305 DOI: 10.1038/S41586-018-0792-9  0.361
2018 Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, et al. A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunology, Immunotherapy : Cii. PMID 30564891 DOI: 10.1007/S00262-018-2282-1  0.317
2018 Ye CJ, Chen J, Villani AC, Gate RE, Subramaniam M, Bhangale T, Lee MN, Raj T, Raychowdhury R, Li W, Rogel N, Simmons S, Imboywa SH, Chipendo PI, McCabe C, ... ... Hacohen N, et al. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection. Genome Research. PMID 30446528 DOI: 10.1101/Gr.240390.118  0.422
2018 Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, ... ... Hacohen N, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 175: 998-1013.e20. PMID 30388456 DOI: 10.1016/J.Cell.2018.10.038  0.405
2018 Ranu N, Villani AC, Hacohen N, Blainey PC. Targeting individual cells by barcode in pooled sequence libraries. Nucleic Acids Research. PMID 30256981 DOI: 10.1093/Nar/Gky856  0.393
2018 Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, ... ... Hacohen N, et al. A cloning and expression system to probe T cell receptor specificity and assess functional avidity to neoantigens. Blood. PMID 30150207 DOI: 10.1182/Blood-2018-04-843763  0.385
2018 Gillies CE, Putler R, Menon R, Otto E, Yasutake K, Nair V, Hoover P, Lieb D, Li S, Eddy S, Fermin D, McNulty MT, Hacohen N, Kiryluk K, et al. An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome. American Journal of Human Genetics. PMID 30057032 DOI: 10.1016/J.Ajhg.2018.07.004  0.392
2018 Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, ... ... Hacohen N, et al. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Research & Therapy. 20: 139. PMID 29996944 DOI: 10.1186/S13075-018-1631-Y  0.319
2018 Grossman SR, Engreitz J, Ray JP, Nguyen TH, Hacohen N, Lander ES. Positional specificity of different transcription factor classes within enhancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29987030 DOI: 10.1073/Pnas.1804663115  0.319
2018 Li T, Kim A, Rosenbluh J, Horn H, Greenfeld L, An D, Zimmer A, Liberzon A, Bistline J, Natoli T, Li Y, Tsherniak A, Narayan R, Subramanian A, Liefeld T, ... ... Hacohen N, et al. GeNets: a unified web platform for network-based genomic analyses. Nature Methods. PMID 29915188 DOI: 10.1038/S41592-018-0039-6  0.303
2018 Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 48: 911-922.e7. PMID 29768176 DOI: 10.1016/J.Immuni.2018.04.011  0.336
2018 Villani AC, Sarkizova S, Hacohen N. Systems Immunology: Learning the Rules of the Immune System. Annual Review of Immunology. 36: 813-842. PMID 29677477 DOI: 10.1146/Annurev-Immunol-042617-053035  0.38
2018 Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, ... ... Hacohen N, et al. Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. PMID 29656892 DOI: 10.1016/J.Cell.2018.03.026  0.339
2018 Baillie JK, Bretherick A, Haley CS, Clohisey S, Gray A, Neyton LPA, Barrett J, Stahl EA, Tenesa A, Andersson R, Brown JB, Faulkner GJ, Lizio M, Schaefer U, Daub C, ... ... Hacohen N, et al. Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. Plos Computational Biology. 14: e1005934. PMID 29494619 DOI: 10.1371/Journal.Pcbi.1005934  0.375
2018 Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, ... ... Hacohen N, et al. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nature Communications. 9: 789. PMID 29476097 DOI: 10.1038/S41467-018-02892-Y  0.356
2018 Pasqual G, Chudnovskiy A, Tas JMJ, Agudelo M, Schweitzer LD, Cui A, Hacohen N, Victora GD. Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling. Nature. PMID 29342141 DOI: 10.1038/Nature25442  0.388
2018 Li S, Sun J, Anandappa A, Spiro O, Leshchiner I, Datta K, Bao Y, Hu Z, Hacohen N, Mathewson ND, Tirosh I, Wucherpfennig K, Regev A, Suva M, Keskin DB, et al. Abstract 5387: Novel targeted single-cell TCR sequencing method used for analysis of a T cell infiltrate from a glioblastoma patient Cancer Research. 78: 5387-5387. DOI: 10.1158/1538-7445.Am2018-5387  0.372
2018 Hoover PJ, Jones TD, Costenbader KH, Hacohen N. TD-07 Dissecting the role of myeloid cells in lupus nephritis Lupus Science & Medicine. 5. DOI: 10.1136/Lupus-2018-Lsm.126  0.413
2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Hacohen N, et al. Science Forum: The Human Cell Atlas. Elife. 6. PMID 29206104 DOI: 10.7554/Elife.27041  0.372
2017 Sarkizova S, Hacohen N. How T cells spot tumour cells. Nature. 551: 444-446. PMID 29168843 DOI: 10.1038/D41586-017-07267-9  0.339
2017 Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, ... ... Hacohen N, et al. Landscape of X chromosome inactivation across human tissues. Nature. 550: 244-248. PMID 29022598 DOI: 10.1038/Nature24265  0.31
2017 Goudot C, Coillard A, Villani AC, Gueguen P, Cros A, Sarkizova S, Tang-Huau TL, Bohec M, Baulande S, Hacohen N, Amigorena S, Segura E. Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. Immunity. 47: 582-596.e6. PMID 28930664 DOI: 10.1016/J.Immuni.2017.08.016  0.337
2017 Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, ... ... Hacohen N, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. PMID 28678778 DOI: 10.1038/Nature22991  0.347
2017 Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Reports. 19: 2853-2866. PMID 28658630 DOI: 10.1016/J.Celrep.2017.06.016  0.766
2017 Chen JH, Pelka K, Hacohen N. Heavy Metal Enlightens Tumor Immunity. Cell. 169: 567-569. PMID 28475889 DOI: 10.1016/J.Cell.2017.04.017  0.301
2017 Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, ... ... Hacohen N, et al. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature Genetics. PMID 28436985 DOI: 10.1038/Ng.3854  0.769
2017 Villani AC, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, Jardine L, Dixon D, Stephenson E, Nilsson E, Grundberg I, ... ... Hacohen N, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science (New York, N.Y.). 356. PMID 28428369 DOI: 10.1126/Science.Aah4573  0.371
2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, ... ... Hacohen N, et al. Author response: The Human Cell Atlas Elife. DOI: 10.7554/Elife.27041.011  0.335
2017 Villani A, Chun Y, Raychowdhury R, Li W, Eisenhaure T, Regev A, Hacohen N. Abstract B13: Integrative genomic and transcriptomic analysis of 775 human cancer cell lines reveals tumor-derived immune programs and their regulators Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B13  0.389
2017 Vu L, Prieto C, Amin EM, Minuesa G, Chhangawala S, Vidal MC, Krivtsov A, Chou T, Chow A, Barlowe T, Taggart J, Tivnan P, Deering RP, Chu LP, Gonen M, ... ... Hacohen N, et al. Abstract IA13: RNA regulators and the control of self-renewal Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Ia13  0.778
2017 Rooney MS, Abelin J, Sarkizova S, Keskin D, Hartigan C, Zhang W, Sidney J, Lane W, Stevens J, Zhang GL, Clauser K, Hacohen N, Carr S, Wu C. Abstract LB-179: Next-generation epitope prediction using mass spectrometry and integrative genomics Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-179  0.315
2017 Berthier C, Rao D, Arazi A, Browne E, Eisenhaure T, Hacohen N, Lieb D, Diamond B, Kretzler M. 264 Pearl: pathway exploration and analysis in renal disease in the accelerating medicine partnership (amp) lupus network Lupus Science & Medicine. 4. DOI: 10.1136/Lupus-2017-000215.264  0.367
2016 Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, ... Hacohen N, et al. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genetics. PMID 27992415 DOI: 10.1038/Ng.3741  0.33
2016 Schumacher TN, Hacohen N. Neoantigens encoded in the cancer genome. Current Opinion in Immunology. 41: 98-103. PMID 27518850 DOI: 10.1016/J.Coi.2016.07.005  0.352
2016 Li B, Li T, Pignon JC, Wang B, Wang J, Shukla SA, Dou R, Chen Q, Hodi FS, Choueiri TK, Wu C, Hacohen N, Signoretti S, Liu JS, Liu XS. Landscape of tumor-infiltrating T cell repertoire of human cancers. Nature Genetics. PMID 27240091 DOI: 10.1038/Ng.3581  0.346
2016 Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, ... Hacohen N, et al. Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 164: 564-578. PMID 26824662 DOI: 10.1016/J.Cell.2015.12.032  0.76
2016 Soucie EL, Weng Z, Geirsdóttir L, Molawi K, Maurizio J, Fenouil R, Mossadegh-Keller N, Gimenez G, VanHille L, Beniazza M, Favret J, Berruyer C, Perrin P, Hacohen N, Andrau JC, et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science (New York, N.Y.). PMID 26797145 DOI: 10.1126/Science.Aad5510  0.38
2016 Togami K, Madan V, Li J, Villani A, Sarkizova S, Ghandi M, Buczkowski K, Li Y, Biichle S, Angelot-Delettre F, Seiler M, Buonamici S, Taylor J, Abdel-Wahab O, Hammerman PS, ... Hacohen N, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Harbors Frequent Splicesosome Mutations That Cause Aberrant RNA Splicing Affecting Genes Critical in pDC Differentiation and Function Blood. 128: 738-738. DOI: 10.1182/Blood.V128.22.738.738  0.351
2016 Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Fritsch E, Hacohen N, Wu CJ. Abstract PR02: A personalized neoantigen vaccine in patients with high risk melanoma Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Pr02  0.303
2016 Li B, Liu T, Wang B, Wang J, Shukla S, Dou R, Hodi S, Wu C, Hacohen N, Liu J, Liu XS. Abstract LB-264: Landscape of tumor-infiltrating T-cell repertoire of human cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-264  0.352
2015 Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS. A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. Molecular Cell. 60: 816-27. PMID 26638175 DOI: 10.1016/J.Molcel.2015.11.013  0.359
2015 Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, ... ... Hacohen N, et al. A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Cell. PMID 26189680 DOI: 10.1016/J.Cell.2015.06.059  0.458
2015 Ray JP, Hacohen N. Impact of autoimmune risk alleles on the immune system. Genome Medicine. 7: 57. PMID 26089985 DOI: 10.1186/S13073-015-0182-Y  0.31
2015 Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nature Immunology. 16: 495-504. PMID 25848864 DOI: 10.1038/Ni.3143  0.382
2015 De Jager PL, Hacohen N, Mathis D, Regev A, Stranger BE, Benoist C. ImmVar project: Insights and design considerations for future studies of "healthy" immune variation. Seminars in Immunology. 27: 51-7. PMID 25819567 DOI: 10.1016/J.Smim.2015.03.003  0.32
2015 Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, ... ... Hacohen N, et al. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science (New York, N.Y.). 347: 1259038. PMID 25745177 DOI: 10.1126/Science.1259038  0.744
2015 Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, et al. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. The Journal of Clinical Investigation. 125: 1286-98. PMID 25664853 DOI: 10.1172/Jci78440  0.751
2015 Rooney MS, Shukla SA, Wu CJ, Getz G, Hacohen N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160: 48-61. PMID 25594174 DOI: 10.1016/J.Cell.2014.12.033  0.315
2015 Hacohen N. Abstract SY11-04: Genetics of immune escape Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy11-04  0.329
2014 Rabani M, Raychowdhury R, Jovanovic M, Rooney M, Stumpo DJ, Pauli A, Hacohen N, Schier AF, Blackshear PJ, Friedman N, Amit I, Regev A. High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies. Cell. 159: 1698-710. PMID 25497548 DOI: 10.1016/J.Cell.2014.11.015  0.38
2014 Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C, Wang L, Li S, Kotliar D, Zhang W, Ghandi M, Garraway L, Fernandes SM, ... ... Hacohen N, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell. 26: 813-25. PMID 25490447 DOI: 10.1016/J.Ccell.2014.10.012  0.305
2014 Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, ... ... Hacohen N, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 159: 440-55. PMID 25263330 DOI: 10.1016/J.Cell.2014.09.014  0.334
2014 Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science (New York, N.Y.). 345: 1254665. PMID 25214635 DOI: 10.1126/Science.1254665  0.352
2014 Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, ... Hacohen N, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Reports. 8: 284-96. PMID 24981863 DOI: 10.1016/J.Celrep.2014.05.048  0.309
2014 Shalek AK, Satija R, Shuga J, Trombetta JJ, Gennert D, Lu D, Chen P, Gertner RS, Gaublomme JT, Yosef N, Schwartz S, Fowler B, Weaver S, Wang J, Wang X, ... ... Hacohen N, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 510: 363-9. PMID 24919153 DOI: 10.1038/Nature13437  0.46
2014 Fritsch EF, Rajasagi M, Ott PA, Brusic V, Hacohen N, Wu CJ. HLA-binding properties of tumor neoepitopes in humans. Cancer Immunology Research. 2: 522-9. PMID 24894089 DOI: 10.1158/2326-6066.Cir-13-0227  0.304
2014 Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, Zhang W, Sougnez C, Cibulskis K, Sidney J, Stevenson K, Ritz J, Neuberg D, Brusic V, Gabriel S, ... ... Hacohen N, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 124: 453-62. PMID 24891321 DOI: 10.1182/Blood-2014-04-567933  0.335
2014 Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, ... ... Hacohen N, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.). 344: 519-23. PMID 24786080 DOI: 10.1126/Science.1249547  0.38
2014 Wang L, Shalek AK, Lawrence M, Ding R, Gaublomme JT, Pochet N, Stojanov P, Sougnez C, Shukla SA, Stevenson KE, Zhang W, Wong J, Sievers QL, MacDonald BT, Vartanov AR, ... ... Hacohen N, et al. Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. Blood. 124: 1089-98. PMID 24778153 DOI: 10.1182/Blood-2014-01-552067  0.341
2014 Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C, Bunnell SC, Hacohen N, Stadecker MJ. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. Journal of Immunology (Baltimore, Md. : 1950). 192: 4655-65. PMID 24729611 DOI: 10.4049/Jimmunol.1400121  0.359
2014 Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, ... ... Hacohen N, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (New York, N.Y.). 343: 1246980. PMID 24604203 DOI: 10.1126/Science.1246980  0.383
2014 Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. Plos Pathogens. 10: e1003904. PMID 24516381 DOI: 10.1371/Journal.Ppat.1003904  0.358
2014 Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, ... ... Hacohen N, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 506: 52-7. PMID 24476824 DOI: 10.1038/Nature12988  0.403
2014 Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proceedings of the National Academy of Sciences of the United States of America. 111: 1491-6. PMID 24434558 DOI: 10.1073/Pnas.1323535111  0.365
2014 Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs. The Journal of Experimental Medicine. 211: 71-87. PMID 24395885 DOI: 10.1084/Jem.20130736  0.757
2014 Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Zhang W, Liao X, Hodi FS, O'Connell K, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, et al. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion. Blood. 123: 1412-21. PMID 24357730 DOI: 10.1182/Blood-2013-08-523001  0.393
2014 Park SM, Gönen M, Vu LP, Minuesa G, Tivnan P, Barlowe T, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa M, Paietta EM, Tallman MS, Melnick AM, Levine RL, et al. Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program Blood. 124: 836-836. DOI: 10.1182/Blood.V124.21.836.836  0.775
2013 Ramirez-Ortiz ZG, Pendergraft WF, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nature Immunology. 14: 917-26. PMID 23892722 DOI: 10.1038/Ni.2670  0.402
2013 Shalek AK, Satija R, Adiconis X, Gertner RS, Gaublomme JT, Raychowdhury R, Schwartz S, Yosef N, Malboeuf C, Lu D, Trombetta JJ, Gennert D, Gnirke A, Goren A, Hacohen N, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature. 498: 236-40. PMID 23685454 DOI: 10.1038/Nature12172  0.473
2013 Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev A. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nature Biotechnology. 31: 342-9. PMID 23503680 DOI: 10.1038/Nbt.2519  0.748
2013 Arazi A, Pendergraft WF, Ribeiro RM, Perelson AS, Hacohen N. Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches. Seminars in Immunology. 25: 193-200. PMID 23375135 DOI: 10.1016/J.Smim.2012.11.003  0.301
2013 Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nature Immunology. 14: 179-85. PMID 23263557 DOI: 10.1038/Ni.2509  0.403
2013 Landau D, Clement K, Boyle P, Ziller M, Stevenson KE, Kotliar D, Saksena G, Eng M, Sougnez C, Zhang W, Ghandi M, Garraway L, Gabriel S, Lander ES, Brown JR, ... ... Hacohen N, et al. Increased Local Disorder of DNA Methylation Forms the Basis of High Intra-Leukemic Epigenetic Heterogeneity and Enhances CLL Evolution Blood. 122: 596-596. DOI: 10.1182/Blood.V122.21.596.596  0.327
2013 Rajasagi M, Shukla SA, Fritsch EF, DeLuca D, Getz G, Hacohen N, Wu CJ. Tumor Neoantigens Are Abundant Across Cancers Blood. 122: 3265-3265. DOI: 10.1182/Blood.V122.21.3265.3265  0.304
2013 Kotliar D, Landau D, Litvin O, Stojanov P, Sougnez C, Saksena G, Eng M, Neuberg DS, Getz G, Brown JR, Pe'er D, Hacohen N, Wu CJ. Reconstructing a Genotype-Phenotype Map In Chronic Lymphocytic Leukemia Blood. 122: 2857-2857. DOI: 10.1182/Blood.V122.21.2857.2857  0.371
2012 Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, et al. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Letters. 12: 6498-504. PMID 23190424 DOI: 10.1021/Nl3042917  0.775
2012 Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, ... ... Hacohen N, et al. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Molecular Cell. 47: 810-22. PMID 22940246 DOI: 10.1016/J.Molcel.2012.07.030  0.75
2012 Moita CF, Chora Â, Hacohen N, Moita LF. RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells. European Journal of Immunology. 42: 1843-9. PMID 22585713 DOI: 10.1002/Eji.201142167  0.38
2012 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Molecular & Cellular Proteomics : McP. 11: 148-59. PMID 22505724 DOI: 10.1074/Mcp.M111.016857  0.304
2012 Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 36: 415-26. PMID 22386268 DOI: 10.1016/J.Immuni.2012.01.013  0.746
2012 Rajasagi M, Keskin D, Kim J, Zhang W, Shukla S, DeLuca D, Sidney J, Brusic V, Neuberg DS, Getz G, Lander ES, Hacohen N, Wu CJ. Systematic Identification of Personal Mutated Tumor-Specific Neoantigens in CLL Blood. 120: 954-954. DOI: 10.1182/Blood.V120.21.954.954  0.338
2012 Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, Kim HT, Alyea EP, Wu CJ. Reversal of T Cell Exhaustion in Pre-Treatment Marrow T Cells Is Associated with Effective Graft-Versus-Leukemia Responses to Donor Lymphocyte Infusion Blood. 120: 1903-1903. DOI: 10.1182/Blood.V120.21.1903.1903  0.4
2011 Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, ... ... Hacohen N, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. The New England Journal of Medicine. 365: 2497-506. PMID 22150006 DOI: 10.1056/Nejmoa1109016  0.324
2011 Amit I, Regev A, Hacohen N. Strategies to discover regulatory circuits of the mammalian immune system. Nature Reviews. Immunology. 11: 873-80. PMID 22094988 DOI: 10.1038/Nri3109  0.362
2011 Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, ... ... Hacohen N, et al. Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 147: 853-67. PMID 22078882 DOI: 10.1016/J.Cell.2011.10.022  0.749
2011 Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB. Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity. 35: 182-93. PMID 21802320 DOI: 10.1016/J.Immuni.2011.06.009  0.378
2011 Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Journal of Immunology (Baltimore, Md. : 1950). 187: 141-50. PMID 21646294 DOI: 10.4049/Jimmunol.1003740  0.351
2011 Vander Lugt B, Beck ZT, Fuhlbrigge RC, Hacohen N, Campbell JJ, Boes M. TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells. Plos One. 6: e20099. PMID 21625453 DOI: 10.1371/Journal.Pone.0020099  0.319
2011 Moura-Alves P, Neves-Costa A, Raquel H, Pacheco TR, D'Almeida B, Rodrigues R, Cadima-Couto I, Chora Â, Oliveira M, Gama-Carvalho M, Hacohen N, Moita LF. An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion. Plos One. 6: e19829. PMID 21611201 DOI: 10.1371/Journal.Pone.0019829  0.336
2011 Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng Q, Chen Z, Mauceli E, Hacohen N, Gnirke A, Rhind N, et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nature Biotechnology. 29: 644-52. PMID 21572440 DOI: 10.1038/Nbt.1883  0.307
2011 Benoist C, Hacohen N. Flow cytometry, amped up Science. 332: 677-678. PMID 21551055 DOI: 10.1126/Science.1206351  0.401
2011 Rabani M, Levin JZ, Fan L, Adiconis X, Raychowdhury R, Garber M, Gnirke A, Nusbaum C, Hacohen N, Friedman N, Amit I, Regev A. Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Nature Biotechnology. 29: 436-42. PMID 21516085 DOI: 10.1038/Nbt.1861  0.326
2011 Pe'er D, Hacohen N. Principles and strategies for developing network models in cancer. Cell. 144: 864-73. PMID 21414479 DOI: 10.1016/J.Cell.2011.03.001  0.331
2011 Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ. Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. The Journal of Clinical Investigation. 121: 1574-84. PMID 21403403 DOI: 10.1172/Jci44581  0.37
2011 Shapira SD, Hacohen N. Systems biology approaches to dissect mammalian innate immunity. Current Opinion in Immunology. 23: 71-7. PMID 21111589 DOI: 10.1016/J.Coi.2010.10.022  0.35
2011 Wang L, Shalek AK, Gaublomme J, Yosef N, Brown JR, Neuberg D, Hacohen N, Park H, Wu CJ. Sensitivity to Wnt Pathway Inhibition in CLL Is Associated with Specific Gene Expression Signatures Blood. 118: 801-801. DOI: 10.1182/Blood.V118.21.801.801  0.425
2011 Wan Y, Lawrence MS, Wang L, Stojanov P, Sougnez C, Stevenson K, Werner L, Zhang W, Folco EG, Tesar B, Sievers QL, Gabriel S, Hacohen N, Reed R, Meyerson M, et al. Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1 Blood. 118: 463-463. DOI: 10.1182/Blood.V118.21.463.463  0.301
2010 Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. The Journal of Experimental Medicine. 207: 2195-206. PMID 20837698 DOI: 10.1084/Jem.20101123  0.41
2010 Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nature Immunology. 11: 495-502. PMID 20473299 DOI: 10.1038/Ni.1878  0.354
2010 Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 141: 668-81. PMID 20451243 DOI: 10.1016/J.Cell.2010.04.018  0.368
2010 Rato S, Maia S, Brito PM, Resende L, Pereira CF, Moita C, Freitas RP, Moniz-Pereira J, Hacohen N, Moita LF, Goncalves J. Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells. Plos One. 5: e9276. PMID 20174665 DOI: 10.1371/Journal.Pone.0009276  0.33
2010 Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. Journal of Immunology (Baltimore, Md. : 1950). 184: 685-93. PMID 20018615 DOI: 10.4049/Jimmunol.0902443  0.358
2010 Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nature Cell Biology. 12: 19-30; sup pp 1-13. PMID 19966785 DOI: 10.1038/Ncb2000  0.337
2010 Wang L, Pochet N, Cibulskis K, Zhang W, Lawrence M, Sievers QL, Shefler E, Neuberg D, Gabriel S, Sougnez C, Regev A, Getz G, Hacohen N, Brown JR, Wu CJ. Whole Genome Sequencing Identifies Functional Mutations In the Wnt Pathway In CLL Blood. 116: 693-693. DOI: 10.1182/Blood.V116.21.693.693  0.407
2009 Shapira SD, Gat-Viks I, Shum BO, Dricot A, de Grace MM, Wu L, Gupta PB, Hao T, Silver SJ, Root DE, Hill DE, Regev A, Hacohen N. A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell. 139: 1255-67. PMID 20064372 DOI: 10.1016/J.Cell.2009.12.018  0.334
2009 Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, ... ... Hacohen N, et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (New York, N.Y.). 326: 257-63. PMID 19729616 DOI: 10.1126/Science.1179050  0.761
2009 Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood. 113: 3690-5. PMID 19188664 DOI: 10.1182/Blood-2008-10-176396  0.353
2009 Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458: 223-7. PMID 19182780 DOI: 10.1038/Nature07672  0.4
2009 Raquel H, Moita C, Hacohen N, Moita L. Identification of genes involved in unconventional protein secretion pathways Cytokine. 48: 118. DOI: 10.1016/J.Cyto.2009.07.499  0.32
2008 Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Hacohen N, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/Pnas.0810485105  0.383
2008 Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (New York, N.Y.). 321: 686-91. PMID 18669861 DOI: 10.1126/Science.1157610  0.378
2008 Adams EW, Ratner DM, Seeberger PH, Hacohen N. Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells. Chembiochem : a European Journal of Chemical Biology. 9: 294-303. PMID 18186095 DOI: 10.1002/Cbic.200700310  0.333
2008 Acharya S, Hacohen N, Soares L, Fathman C. OR.37. shRNA Mediated Downregulation of Genes Identified as ‘Core Transcriptome’ in Murine T Regulatory Cells Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.503  0.375
2008 Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi Library Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.074  0.301
2006 Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M. RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts. Molecular Biology of the Cell. 17: 4187-99. PMID 16855028 DOI: 10.1091/Mbc.E06-01-0036  0.426
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/J.Cell.2006.01.040  0.358
2006 Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.385  0.346
2004 Palliser D, Huang Q, Hacohen N, Lamontagne SP, Guillen E, Young RA, Eisen HN. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. Journal of Immunology (Baltimore, Md. : 1950). 172: 2885-93. PMID 14978090 DOI: 10.4049/Jimmunol.172.5.2885  0.346
2002 Alcamo E, Hacohen N, Schulte LC, Rennert PD, Hynes RO, Baltimore D. Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. The Journal of Experimental Medicine. 195: 233-44. PMID 11805150 DOI: 10.1084/Jem.20011885  0.319
2001 Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, Lander ES, Hacohen N. The plasticity of dendritic cell responses to pathogens and their components. Science (New York, N.Y.). 294: 870-5. PMID 11679675 DOI: 10.1126/Science.294.5543.870  0.413
1998 Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell. 92: 253-63. PMID 9458049 DOI: 10.1016/S0092-8674(00)80919-8  0.329
1996 Lee T, Hacohen N, Krasnow M, Montell DJ. Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes & Development. 10: 2912-21. PMID 8918892 DOI: 10.1101/Gad.10.22.2912  0.378
Low-probability matches (unlikely to be authored by this person)
2009 Savina A, Peres A, Cebrian I, Carmo N, Moita C, Hacohen N, Moita LF, Amigorena S. The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells. Immunity. 30: 544-55. PMID 19328020 DOI: 10.1016/J.Immuni.2009.01.013  0.299
2017 Sade-Feldman M, Jiao YJ, Chen JH, Rooney MS, Barzily-Rokni M, Eliane JP, Bjorgaard SL, Hammond MR, Vitzthum H, Blackmon SM, Frederick DT, Hazar-Rethinam M, Nadres BA, Van Seventer EE, Shukla SA, ... ... Hacohen N, et al. Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Nature Communications. 8: 1136. PMID 29070816 DOI: 10.1038/S41467-017-01062-W  0.297
2018 Reardon D, Keskin D, Tirosh I, Anandappa A, Mathewson N, Sun J, Shukla S, Gjini E, Li S, Giobbie-Hurder A, McCluskey C, Chiocca EA, Neuberg D, Wucherpfennig K, Suva M, ... ... Hacohen N, et al. ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS Neuro-Oncology. 20: vi8-vi8. DOI: 10.1093/Neuonc/Noy148.027  0.295
2019 Chapuy L, Bsat M, Rubio M, Harvey F, Motta V, Schwenter F, Wassef R, Richard C, Deslandres C, Nguyen BN, Soucy G, Hacohen N, Fritz J, Villani AC, Mehta H, et al. Transcriptomic analysis and High dimensional phenotypic mapping of mononuclear phagocytes in mesenteric lymph nodes reveal differences between ulcerative colitis and Crohn's disease. Journal of Crohn's & Colitis. PMID 31541232 DOI: 10.1093/Ecco-Jcc/Jjz156  0.295
2014 Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, ... ... Hacohen N, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65. PMID 24444711 DOI: 10.1158/2159-8290.Cd-13-0646  0.292
2020 Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, ... ... Hacohen N, et al. Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology. PMID 32341567 DOI: 10.1038/S41587-020-0534-Z  0.291
2017 Abelin JG, Keskin DB, Sarkizova S, Hartigan CR, Zhang W, Sidney J, Stevens J, Lane W, Zhang GL, Eisenhaure TM, Clauser KR, Hacohen N, Rooney MS, Carr SA, Wu CJ. Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction. Immunity. 46: 315-326. PMID 28228285 DOI: 10.1016/J.Immuni.2017.02.007  0.291
2019 Reyes M, Billman K, Hacohen N, Blainey PC. Simultaneous profiling of gene expression and chromatin accessibility in single cells. Advanced Biosystems. 3. PMID 31853478 DOI: 10.1002/adbi.201900065  0.291
1989 Assad JA, Hacohen N, Corey DP. Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. Proceedings of the National Academy of Sciences of the United States of America. 86: 2918-22. PMID 2468161 DOI: 10.1073/Pnas.86.8.2918  0.29
2013 Hacohen N, Fritsch EF, Carter TA, Lander ES, Wu CJ. Getting personal with neoantigen-based therapeutic cancer vaccines. Cancer Immunology Research. 1: 11-5. PMID 24777245 DOI: 10.1158/2326-6066.Cir-13-0022  0.289
2021 Price C, Chen J, Pelka K, Chao S, He J, Boland G, Emanuel G, Hacohen N. 920 A single-cell spatially resolved MERFISH map of the colorectal tumor immune microenvironment Journal For Immunotherapy of Cancer. 9: A965-A965. DOI: 10.1136/jitc-2021-sitc2021.920  0.288
2006 Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods. 3: 715-9. PMID 16929317 DOI: 10.1038/Nmeth924  0.287
2019 Sarkizova S, Klaeger S, Keskin DB, Clauser K, Keshishian H, Hartigan CR, Hacohen N, Carr SA, Wu CJ. Abstract B042: Broad analysis and more accurate predictions of HLA class I epitope binding in 92 common HLA alleles profiled by mono-allelic mass spectrometry Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B042  0.287
2013 Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, Sougnez C, Stewart C, Sivachenko A, Wang L, Wan Y, Zhang W, Shukla SA, Vartanov A, Fernandes SM, ... ... Hacohen N, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 152: 714-26. PMID 23415222 DOI: 10.1016/J.Cell.2013.01.019  0.285
2023 Fox DB, Ebright RY, Hong X, Russell HC, Guo H, LaSalle TJ, Wittner BS, Poux N, Vuille JA, Toner M, Hacohen N, Boland GM, Sen DR, Sullivan RJ, Maheswaran S, et al. Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. Npj Precision Oncology. 7: 25. PMID 36864091 DOI: 10.1038/s41698-023-00362-3  0.284
2011 Landau D, Stojanov P, Lawrence MS, Sougnez C, McKeena A, Carter S, Gabriel S, Neuberg D, Hacohen N, Lander ES, Brown JR, Getz G, Wu C. Shifts in Intra-Clonal Dynamics Rather Than Novel Mutations Are the Main Engine Driving Tumor Evolution in Relapsed CLL Blood. 118: 284-284. DOI: 10.1182/Blood.V118.21.284.284  0.282
2009 Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. The Journal of Experimental Medicine. 206: 637-53. PMID 19237602 DOI: 10.1084/Jem.20082109  0.282
2018 Reardon DA, Neuberg DS, Keskin DB, Tirosh I, Anandappa A, Mathewson ND, Sun J, Shukla SA, Gjini E, Li S, Giobbie-Hurder A, Wucherpfennig K, Suva M, Fritsch E, Rodig S, ... ... Hacohen N, et al. Effect of dexamethasone in glioblastoma (GBM) patients on systemic and intratumoral T-cell responses induced by personalized neoantigen-targeting vaccine. Journal of Clinical Oncology. 36: 2020-2020. DOI: 10.1200/Jco.2018.36.15_Suppl.2020  0.282
2024 Chen JH, Nieman LT, Spurrell M, Jorgji V, Elmelech L, Richieri P, Xu KH, Madhu R, Parikh M, Zamora I, Mehta A, Nabel CS, Freeman SS, Pirl JD, Lu C, ... ... Hacohen N, et al. Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature Immunology. PMID 38503922 DOI: 10.1038/s41590-024-01792-2  0.28
2015 Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, ... ... Hacohen N, et al. Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host & Microbe. 18: 723-735. PMID 26651948 DOI: 10.1016/J.Chom.2015.11.002  0.28
2020 Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, ... ... Hacohen N, et al. Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients. Biorxiv : the Preprint Server For Biology. PMID 33173871 DOI: 10.1101/2020.11.02.365536  0.278
2021 Nasser J, Bergman DT, Fulco CP, Guckelberger P, Doughty BR, Patwardhan TA, Jones TR, Nguyen TH, Ulirsch JC, Lekschas F, Mualim K, Natri HM, Weeks EM, Munson G, Kane M, ... ... Hacohen N, et al. Genome-wide enhancer maps link risk variants to disease genes. Nature. PMID 33828297 DOI: 10.1038/s41586-021-03446-x  0.276
2023 Chen JH, Nieman LT, Spurrell M, Jorgji V, Richieri P, Xu KH, Madhu R, Parikh M, Zamora I, Mehta A, Nabel CS, Freeman SS, Pirl JD, Lu C, Meador CB, ... ... Hacohen N, et al. Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response. Biorxiv : the Preprint Server For Biology. PMID 37066412 DOI: 10.1101/2023.04.04.535379  0.276
2021 Wang C, Cui A, Bukenya M, Aung A, Pradhan D, Whittaker CA, Agarwal Y, Thomas A, Liang S, Amlashi P, Suh H, Spranger S, Hacohen N, Irvine DJ. Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade. Cell Reports. 37: 110021. PMID 34818534 DOI: 10.1016/j.celrep.2021.110021  0.275
1989 Assad JA, Hacohen N, Corey DP. Localization and biophysical characterization of an adaptation mechanism in amphibian hair cells The Journal of the Acoustical Society of America. 85: S30-S30. DOI: 10.1121/1.2026903  0.275
2016 Rooney MS, Abelin JG, Keskin DB, Sarkizova S, Hartigan C, Zhang W, Sidney J, Stevens J, Lane WJ, Zhang GL, Clauser KR, Hacohen N, Carr SA, Wu CJ. Abstract B089: High-throughput profiling of HLA allele-specific peptides by MS for improved epitope prediction Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B089  0.274
2015 Shukla SA, Rooney MS, Rajasagi M, Tiao G, Dixon PM, Lawrence MS, Stevens J, Lane WJ, Dellagatta JL, Steelman S, Sougnez C, Cibulskis K, Kiezun A, Hacohen N, Brusic V, et al. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nature Biotechnology. PMID 26372948 DOI: 10.1038/Nbt.3344  0.273
2021 Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S, Sade-Feldman M, Tabach Y, Yizhak K, Navon A, Stepensky P, Hacohen N, Peretz T, Veillette A, et al. Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T cell effector functions. Cancer Immunology Research. PMID 33762352 DOI: 10.1158/2326-6066.CIR-20-0800  0.272
2021 Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, ... ... Hacohen N, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. PMID 34450029 DOI: 10.1016/j.cell.2021.08.003  0.271
2021 Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, ... ... Hacohen N, et al. Longitudinal proteomic analysis of plasma from patients with severe COVID-19 reveal patient survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Reports. Medicine. 100287. PMID 33969320 DOI: 10.1016/j.xcrm.2021.100287  0.269
2021 Thomas M, Slowikowski K, Manakongtreecheep K, Jessica T, Nasrallah M, Leyre Z, Chan E, Genevieve B, Reynolds K, Khalili H, Dougan M, Hacohen N, Li B, Villani A. 240 SINGLE-CELL RNA SEQUENCING REVEALS TRANSCRIPTIONAL SIGNATURES OF IMMUNE AND EPITHELIAL DYSREGULATION THAT DEFINE COLITIS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS Gastroenterology. 160: S-51. DOI: 10.1016/s0016-5085(21)00868-4  0.267
2016 Schumacher TN, Hacohen N. Editorial overview: Cancer immunology: genomics & biomarkers: Cancer immunity through the prism of genomics and proteomics. Current Opinion in Immunology. PMID 27506117 DOI: 10.1016/J.Coi.2016.07.006  0.266
2002 Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes. 51: 1319-36. PMID 11978627 DOI: 10.2337/Diabetes.51.5.1319  0.266
2019 Mehta A, Kasumova G, Rucevic M, Sallman-Almen M, Rosenberg LH, Kim MS, Lieb D, Bai X, Frederick DT, Sullivan RJ, Flaherty K, Hacohen N, Boland GM. Liquid biopsy using plasma proteomic profiling to reveal predictors of immunotherapy response. Journal of Clinical Oncology. 37: 130-130. DOI: 10.1200/Jco.2019.37.8_Suppl.130  0.264
2021 Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, ... ... Hacohen N, et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell. PMID 34910928 DOI: 10.1016/j.cell.2021.11.031  0.264
2019 Hoover P, Der E, Berthier CC, Arazi A, Lederer JA, James JA, Buyon J, Petri M, Belmont HM, Izmirly P, Wofsy D, Hacohen N, Diamond B, Putterman C, Davidson A. The Accelerating Medicines Partnership - Organizational Structure and Preliminary Data from the Phase 1 Studies of Lupus Nephritis. Arthritis Care & Research. PMID 31502417 DOI: 10.1002/Acr.24066  0.263
2019 Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, ... ... Hacohen N, et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nature Biotechnology. PMID 31844290 DOI: 10.1038/S41587-019-0322-9  0.262
2014 Fritsch EF, Hacohen N, Wu CJ. Personal neoantigen cancer vaccines: The momentum builds. Oncoimmunology. 3: e29311. PMID 25101225 DOI: 10.4161/Onci.29311  0.262
2014 Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N. Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Reports. 9: 180-92. PMID 25284779 DOI: 10.1016/J.Celrep.2014.08.074  0.261
2006 Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/Nmeth1006-777  0.261
2023 Carlson RJ, Leiken MD, Guna A, Hacohen N, Blainey PC. A genome-wide optical pooled screen reveals regulators of cellular antiviral responses. Proceedings of the National Academy of Sciences of the United States of America. 120: e2210623120. PMID 37043539 DOI: 10.1073/pnas.2210623120  0.259
2022 Dubrot J, Du PP, Lane-Reticker SK, Kessler EA, Muscato AJ, Mehta A, Freeman SS, Allen PM, Olander KE, Ockerman KM, Wolfe CH, Wiesmann F, Knudsen NH, Tsao HW, Iracheta-Vellve A, ... ... Hacohen N, et al. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nature Immunology. PMID 36151395 DOI: 10.1038/s41590-022-01315-x  0.258
2019 Verma V, Shrimali RK, Ahmad S, Dai W, Wang H, Lu S, Nandre R, Gaur P, Lopez J, Sade-Feldman M, Yizhak K, Bjorgaard SL, Flaherty KT, Wargo JA, Boland GM, ... ... Hacohen N, et al. PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1CD38 cells and anti-PD-1 resistance. Nature Immunology. PMID 31358999 DOI: 10.1038/S41590-019-0441-Y  0.256
2021 Oliveira G, Stromhaug K, Klaeger S, Kula T, Frederick DT, Le PM, Forman J, Huang T, Li S, Zhang W, Xu Q, Cieri N, Clauser KR, Shukla SA, Neuberg D, ... ... Hacohen N, et al. Phenotype, specificity and avidity of antitumour CD8 T cells in melanoma. Nature. PMID 34290406 DOI: 10.1038/s41586-021-03704-y  0.255
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2010 Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, Moita LF, Anes E. Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome Cellular Microbiology. 12: 1046-1063. PMID 20148899 DOI: 10.1111/J.1462-5822.2010.01450.X  0.252
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2013 Cheng CS, Rai K, Garber M, Hollinger A, Robbins D, Anderson S, Macbeth A, Tzou A, Carneiro MO, Raychowdhury R, Russ C, Hacohen N, Gershenwald JE, Lennon N, Nusbaum C, et al. Semiconductor-based DNA sequencing of histone modification states. Nature Communications. 4: 2672. PMID 24157732 DOI: 10.1038/Ncomms3672  0.242
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2021 Dahlqvist J, Fulco CP, Ray JP, Liechti T, de Boer CG, Lieb DJ, Eisenhaure TM, Engreitz JM, Roederer M, Hacohen N. Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease. Human Molecular Genetics. PMID 34970970 DOI: 10.1093/hmg/ddab372  0.233
2019 Verma V, Shrimali RK, Ahmad S, Dai W, Wang H, Lu S, Nandre R, Gaur P, Lopez J, Sade-Feldman M, Yizhak K, Bjorgaard SL, Flaherty KT, Wargo JA, Boland GM, ... ... Hacohen N, et al. Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1CD38 cells and anti-PD-1 resistance. Nature Immunology. PMID 31551574 DOI: 10.1038/S41590-019-0519-6  0.232
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2019 Thomas M, Nasrallah M, Manakongtreecheep K, Ge W, Leyre Z, Hacohen N, Reynolds K, Dougan M, Villani A. Mo1106 – Immunologic Dissection of Colitis Related to Checkpoint Inhibitor Immunotherapy Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)38703-7  0.226
1999 Minowada G, Jarvis L, Chi C, Neubuser A, Sun X, Hacohen N, Krasnow M, Martin G. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed Development. 126: 4465-4475. DOI: 10.1242/DEV.126.20.4465  0.224
2020 Truex NL, Holden RL, Wang BY, Chen PG, Hanna S, Hu Z, Shetty K, Olive O, Neuberg D, Hacohen N, Keskin DB, Ott PA, Wu CJ, Pentelute BL. Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy. Scientific Reports. 10: 723. PMID 31959774 DOI: 10.1038/S41598-019-56943-5  0.224
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2024 Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, ... ... Hacohen N, et al. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. Biorxiv : the Preprint Server For Biology. PMID 38293222 DOI: 10.1101/2024.01.14.575609  0.218
2020 Corcoran R, Giannakis M, Allen J, Chen J, Pelka K, Chao S, Meyerhardt J, Enzinger A, Enzinger P, McCleary N, Yugelun M, Abrams T, Kanter K, Seventer EV, Bradford W, ... ... Hacohen N, et al. SO-26 Clinical efficacy of combined BRAF, MEK, and PD-1 inhibition in BRAFV600E colorectal cancer patients Annals of Oncology. 31. DOI: 10.1016/J.Annonc.2020.04.041  0.218
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2024 Milling LE, Markson SC, Tjokrosurjo Q, Derosia NM, Streeter ISL, Hickok GH, Lemmen AM, Nguyen TH, Prathima P, Fithian W, Schwartz MA, Hacohen N, Doench JG, LaFleur MW, Sharpe AH. Framework for in vivo T cell screens. The Journal of Experimental Medicine. 221. PMID 38411617 DOI: 10.1084/jem.20230699  0.21
2021 Maciag K, Raychowdhury R, Smith K, Schneider AM, Coers J, Mumbach MR, Schwartz S, Hacohen N. IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR. Journal of Leukocyte Biology. PMID 34826345 DOI: 10.1002/JLB.3A0218-069RR  0.21
2022 LaSalle TJ, Gonye ALK, Freeman SS, Kaplonek P, Gushterova I, Kays KR, Manakongtreecheep K, Tantivit J, Rojas-Lopez M, Russo BC, Sharma N, Thomas MF, Lavin-Parsons KM, Lilly BM, Mckaig BN, ... ... Hacohen N, et al. Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients. Cell Reports. Medicine. 100779. PMID 36208629 DOI: 10.1016/j.xcrm.2022.100779  0.208
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2021 Ouspenskaia T, Law T, Clauser KR, Klaeger S, Sarkizova S, Aguet F, Li B, Christian E, Knisbacher BA, Le PM, Hartigan CR, Keshishian H, Apffel A, Oliveira G, Zhang W, ... ... Hacohen N, et al. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. Nature Biotechnology. PMID 34663921 DOI: 10.1038/s41587-021-01021-3  0.206
2021 Tonnerre P, Wolski D, Subudhi S, Aljabban J, Hoogeveen RC, Damasio M, Drescher HK, Bartsch LM, Tully DC, Sen DR, Bean DJ, Brown J, Torres-Cornejo A, Robidoux M, Kvistad D, ... ... Hacohen N, et al. Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory. Nature Immunology. 22: 1030-1041. PMID 34312544 DOI: 10.1038/s41590-021-00982-6  0.206
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2022 Wang C, Li Y, Kaplonek P, Gentili M, Fischinger S, Bowman KA, Sade-Feldman M, Kays KR, Regan J, Flynn JP, Goldberg MB, Hacohen N, Filbin MR, Lauffenburger DA, Alter G, et al. The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia. Mbio. e0157722. PMID 35762593 DOI: 10.1128/mbio.01577-22  0.2
2022 Cohn O, Yankovitz G, Peshes-Yaloz N, Steuerman Y, Frishberg A, Brandes R, Mandelboim M, Hamilton JR, Hagai T, Amit I, Netea MG, Hacohen N, Iraqi FA, Bacharach E, Gat-Viks I. Distinct gene programs underpinning disease tolerance and resistance in influenza virus infection. Cell Systems. PMID 36516834 DOI: 10.1016/j.cels.2022.11.004  0.2
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2017 Sarkizova S, Hacohen N. How T cells spot tumour cells. Nature. 551: 444-446. PMID 32080587 DOI: 10.1038/d41586-017-07267-9  0.198
2024 Revach OY, Cicerchia AM, Shorer O, Petrova B, Anderson S, Park J, Chen L, Mehta A, Wright SJ, McNamee N, Tal-Mason A, Cattaneo G, Tiwari P, Xie H, Sweere JM, ... ... Hacohen N, et al. Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy. Biorxiv : the Preprint Server For Biology. PMID 38405985 DOI: 10.1101/2024.02.12.579184  0.197
2021 Raychowdhury R, Gentili M, Cui A, Schweitzer LD, Li B, Hacohen N. Macrophages from Rosa26-Integrated Cas9-Expressing C57BL/6J Mice Have a Putative TRIF-Mediated Defect in the TLR-3/4 Signaling. Immunohorizons. 5: 818-829. PMID 34667099 DOI: 10.4049/immunohorizons.2100010  0.196
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2018 Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, ... ... Hacohen N, et al. Corrigendum: Landscape of X chromosome inactivation across human tissues. Nature. 555: 274. PMID 29517003 DOI: 10.1038/Nature25993  0.193
2023 Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, ... ... Hacohen N, et al. macrophage polarity identifies a network of cellular programs that control human cancers. Science (New York, N.Y.). 381: 515-524. PMID 37535729 DOI: 10.1126/science.ade2292  0.19
2023 Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, ... ... Hacohen N, et al. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.). 379: eabn8934. PMID 36701450 DOI: 10.1126/science.abn8934  0.19
2021 Oliveira G, Stromhaug K, Klaeger S, Cieri N, Iorgulescu B, Li S, Braun D, Neuberg D, Carr S, Livak K, Tompers D, Fritsch E, Wind-Rotolo M, Hacohen N, Sade-Feldman M, et al. 655 Landscape of helper and regulatory CD4+ T cells in melanoma Journal For Immunotherapy of Cancer. 9: A684-A684. DOI: 10.1136/jitc-2021-sitc2021.655  0.19
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2017 Carter AC, Chang HY, Church G, Dombkowski A, Ecker JR, Gil E, Giresi PG, Greely H, Greenleaf WJ, Hacohen N, He C, Hill D, Ko J, Kohane I, Kundaje A, et al. Challenges and recommendations for epigenomics in precision health. Nature Biotechnology. 35: 1128-1132. PMID 29220033 DOI: 10.1038/Nbt.4030  0.185
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2023 Al'Khafaji AM, Smith JT, Garimella KV, Babadi M, Popic V, Sade-Feldman M, Gatzen M, Sarkizova S, Schwartz MA, Blaum EM, Day A, Costello M, Bowers T, Gabriel S, Banks E, ... ... Hacohen N, et al. High-throughput RNA isoform sequencing using programmed cDNA concatenation. Nature Biotechnology. PMID 37291427 DOI: 10.1038/s41587-023-01815-7  0.181
2021 Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, Kang J, Dayal D, Martin P, Nowak R, Hsieh CL, Feldman J, Julg B, Nilles EJ, Musk ER, ... ... Hacohen N, et al. Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19. Biorxiv : the Preprint Server For Biology. PMID 34013263 DOI: 10.1101/2021.05.11.443609  0.181
2023 Hasegawa T, Oka T, Son HG, Oliver-García VS, Azin M, Eisenhaure TM, Lieb DJ, Hacohen N, Demehri S. Cytotoxic CD4 T cells eliminate senescent cells by targeting cytomegalovirus antigen. Cell. 186: 1417-1431.e20. PMID 37001502 DOI: 10.1016/j.cell.2023.02.033  0.174
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2020 Hong X, Roh W, Sullivan RJ, Wong KHK, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley B, Horwitz E, Boland GM, Marvin DL, Bonesteel T, Lu C, Aguet F, ... ... Hacohen N, et al. The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis. Cancer Discovery. PMID 33203734 DOI: 10.1158/2159-8290.CD-19-1500  0.156
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2023 Genshaft AS, Subudhi S, Keo A, Sanchez Vasquez JD, Conceição-Neto N, Mahamed D, Boeijen LL, Alatrakchi N, Oetheimer C, Vilme M, Drake R, Fleming I, Tran N, Tzouanas C, Joseph-Chazan J, ... ... Hacohen N, et al. Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients. Hepatology (Baltimore, Md.). PMID 37158243 DOI: 10.1097/HEP.0000000000000438  0.154
2020 Wells DK, van Buuren MM, Dang KK, Hubbard-Lucey VM, Sheehan KCF, Campbell KM, Lamb A, Ward JP, Sidney J, Blazquez AB, Rech AJ, Zaretsky JM, Comin-Anduix B, Ng AHC, Chour W, ... ... Hacohen N, et al. Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell. PMID 33038342 DOI: 10.1016/j.cell.2020.09.015  0.152
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2021 Kim DW, Heather J, Lee G, Van Seventer EE, Fish MG, Corcoran RB, Hacohen N, Klempner SJ, Cobbold M, Hong TS. Increased T-cell receptor repertoire diversity to predict better overall survival in gastrointestinal malignancies. Journal of Clinical Oncology. 39: 474-474. DOI: 10.1200/JCO.2021.39.3_SUPPL.474  0.139
2020 Kim D, Heather J, Lee G, Sepulveda S, Van Seventer E, Fish M, Corcoran R, Hacohen N, Klempner S, Cobbold M, Hong T. Serial T-cell Receptor (TCR) Repertoire Sequencing to Predict Outcomes in Gastrointestinal (GI) Malignancies International Journal of Radiation Oncology*Biology*Physics. 108: S110. DOI: 10.1016/j.ijrobp.2020.07.2296  0.136
2021 Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine D, Arazi A, Berthier CC, Davidson A, James JA, ... ... Hacohen N, et al. Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 34783463 DOI: 10.1002/art.42023  0.134
2023 Cui A, Li B, Wallace MS, Gonye ALK, Oetheimer C, Patel H, Tonnerre P, Holmes JA, Lieb D, Yao BS, Ma A, Roberts K, Damasio M, Chen JH, Piou D, ... ... Hacohen N, et al. Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis. Journal of Hepatology. PMID 36972796 DOI: 10.1016/j.jhep.2023.02.040  0.133
2024 Fava A, Buyon J, Magder L, Hodgin J, Rosenberg A, Demeke DS, Rao DA, Arazi A, Celia AI, Putterman C, Anolik JH, Barnas J, Dall'Era M, Wofsy D, Furie R, ... ... Hacohen N, et al. Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis. Jci Insight. 9. PMID 38258904 DOI: 10.1172/jci.insight.172569  0.129
2020 Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, ... ... Hacohen N, et al. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science (New York, N.Y.). PMID 32994364 DOI: 10.1126/science.abd4250  0.129
2023 Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, ... Hacohen N, et al. Author Correction: Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nature Biotechnology. PMID 37653227 DOI: 10.1038/s41587-023-01942-1  0.126
2020 Miller PG, Gibson CJ, Mehta A, Sperling AS, Frederick DT, Manos MP, Miao B, Hacohen N, Hodi FS, Boland GM, Ebert BL. Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade. Jco Precision Oncology. 4. PMID 33015529 DOI: 10.1200/PO.20.00186  0.124
2021 Klaeger S, Apffel A, Clauser KR, Sarkizova S, Oliveira G, Rachimi S, Le PM, Tarren A, Chea V, Abelin JG, Braun DA, Ott PA, Keshishian H, Hacohen N, Keskin DB, et al. Optimized liquid and gas phase fractionation increases HLA-peptidome coverage for primary cell and tissue samples. Molecular & Cellular Proteomics : McP. 100133. PMID 34391888 DOI: 10.1016/j.mcpro.2021.100133  0.123
2023 Gonye ALK, LaSalle TJ, Freeman SS, Reyes M, Hacohen N, Villani AC, Sade-Feldman M. Protocol for bulk RNA sequencing of enriched human neutrophils from whole blood and estimation of sample purity. Star Protocols. 4: 102125. PMID 36853705 DOI: 10.1016/j.xpro.2023.102125  0.122
2021 Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, Kang J, Dayal D, Martin P, Nowak RP, Villani AC, Hsieh CL, Charland NC, Gonye ALK, Gushterova I, ... ... Hacohen N, et al. Early cross-coronavirus reactive signatures of humoral immunity against COVID-19. Science Immunology. 6: eabj2901. PMID 34652962 DOI: 10.1126/sciimmunol.abj2901  0.12
2021 Ward RA, Aghaeepour N, Bhattacharyya RP, Clish CB, Gaudillière B, Hacohen N, Mansour MK, Mudd PA, Pasupneti S, Presti RM, Rhee EP, Sen P, Spec A, Tam JM, Villani AC, et al. Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease. Open Forum Infectious Diseases. 8: ofab483. PMID 34805429 DOI: 10.1093/ofid/ofab483  0.119
2021 Chen X, Gentili M, Hacohen N, Regev A. A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies. Nature Communications. 12: 5506. PMID 34535642 DOI: 10.1038/s41467-021-25777-z  0.117
2015 Ray JP, Hacohen N. Impact of autoimmune risk alleles on the immune system Genome Medicine. 7. DOI: 10.1186/s13073-015-0182-y  0.116
2021 de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, et al. Rationale and design of the Kidney Precision Medicine Project. Kidney International. 99: 498-510. PMID 33637194 DOI: 10.1016/j.kint.2020.08.039  0.113
2023 Ferkowicz MJ, Winfree S, Sabo AR, Kamocka MM, Khochare S, Barwinska D, Eadon MT, Cheng YH, Phillips CL, Sutton TA, Kelly KJ, Dagher PC, El-Achkar TM, Dunn KW, Knight R, ... ... Hacohen N, et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Laboratory Investigation; a Journal of Technical Methods and Pathology. 101: 661-676. PMID 36775387 DOI: 10.1038/s41374-020-00518-w  0.112
2021 Li Y, Schneider AM, Mehta A, Sade-Feldman M, Kays KR, Gentili M, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, ... ... Hacohen N, et al. SARS-CoV-2 Viremia is Associated with Distinct Proteomic Pathways and Predicts COVID-19 Outcomes. Medrxiv : the Preprint Server For Health Sciences. PMID 33655257 DOI: 10.1101/2021.02.24.21252357  0.108
2023 Jin W, Sarkizova S, Chen X, Hacohen N, Uhler C. Unsupervised Protein-Ligand Binding Energy Prediction via Neural Euler's Rotation Equation. Arxiv. PMID 38168456  0.104
2020 Chen X, Gentili M, Hacohen N, Regev A. A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies. Biorxiv : the Preprint Server For Biology. PMID 33140055 DOI: 10.1101/2020.10.29.361287  0.1
2023 Liu B, Carlson RJ, Pires IS, Gentili M, Feng E, Hellier Q, Schwartz MA, Blainey PC, Irvine DJ, Hacohen N. Human STING is a proton channel. Science (New York, N.Y.). 381: 508-514. PMID 37535724 DOI: 10.1126/science.adf8974  0.095
2023 Alvarez-Breckenridge C, Anderson KG, Correia AL, Demehri S, Dinh HQ, Dixon KO, Dunn GP, Evgin L, Goc J, Good Z, Hacohen N, Han P, Hanč P, Hickey J, Kersten K, et al. Lessons for the Next Generation of Scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium. Cancer Immunology Research. OF1-OF7. PMID 37906619 DOI: 10.1158/2326-6066.CIR-23-0522  0.084
2021 Parikh AR, Szabolcs A, Allen JN, Clark JW, Wo JY, Raabe M, Thel H, Hoyos D, Mehta A, Arshad S, Lieb DJ, Drapek LC, Blaszkowsky LS, Giantonio BJ, Weekes CD, ... ... Hacohen N, et al. Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial Nature Cancer. 2: 1124-1135. DOI: 10.1038/s43018-021-00269-7  0.062
2021 Regan J, Flynn JP, Rosenthal A, Jordan H, Li Y, Chishti R, Giguel F, Corry H, Coxen K, Fajnzylber J, Gillespie E, Kuritzkes DR, Hacohen N, Goldberg MB, Filbin MR, et al. Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019. Open Forum Infectious Diseases. 8: ofab153. PMID 34430669 DOI: 10.1093/ofid/ofab153  0.053
2021 Leisman DE, Mehta A, Thompson BT, Charland NC, Gonye ALK, Gushterova I, Kays KR, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, ... ... Hacohen N, et al. Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. American Journal of Respiratory and Critical Care Medicine. PMID 34878969 DOI: 10.1164/rccm.202106-1514OC  0.046
2022 Leisman DE, Mehta A, Thompson BT, Hacohen N, Filbin MR, Goldberg MB. Reply To: High Renin Levels in Severe COVID-19 are Indicative for a Hypo-Renin-Angiotensin-System State. American Journal of Respiratory and Critical Care Medicine. PMID 35348420 DOI: 10.1164/rccm.202202-0292LE  0.032
2021 Fenyves BG, Mehta A, Kays KR, Beakes C, Margolin J, Goldberg MB, Hacohen N, Filbin MR. Plasma P-selectin is an early marker of thromboembolism in COVID-19. American Journal of Hematology. PMID 34622480 DOI: 10.1002/ajh.26372  0.027
2021 Gentili M, Hacohen N. Some antibodies can dampen antiviral defences in people with severe COVID. Nature. 591: 37-39. PMID 33654298 DOI: 10.1038/d41586-021-00352-0  0.021
2019 Hacohen N, Lan YY. Damaged DNA marching out of aging nucleus. Aging. PMID 31581135 DOI: 10.18632/aging.102340  0.019
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