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Rachel L. Graham, Ph.D. - Publications

Affiliations: 
2006 Vanderbilt University, Nashville, TN 
Area:
Microbiology
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Boon ACM, Bricker TL, Fritch EJ, Leist SR, Gully K, Baric RS, Graham RL, Troan BV, Mahoney M, Janetka JW. Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of Virology. e0190323. PMID 38593045 DOI: 10.1128/jvi.01903-23  0.381
2024 Schäfer A, Gralinski LE, Leist SR, Hampton BK, Mooney MA, Jensen KL, Graham RL, Agnihothram S, Jeng S, Chamberlin S, Bell TA, Scobey DT, Linnertz CL, VanBlargan LA, Thackray LB, et al. Genetic Loci Regulate Sarbecovirus Pathogenesis: A Comparison across Mice and Humans. Virus Research. 199357. PMID 38508400 DOI: 10.1016/j.virusres.2024.199357  0.37
2024 Boon ACM, L Bricker T, Fritch EJ, Leist SR, Gully K, Baric RS, Graham RL, Troan BV, Mahoney M, Janetka JW. Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. Biorxiv : the Preprint Server For Biology. PMID 38405752 DOI: 10.1101/2024.02.09.579701  0.361
2023 Fritch EJ, Sanders W, Sims AC, Herring LE, Barker NK, Schepmoes AA, Weitz KK, Texier JR, Dittmer DP, Graves LM, Smith RD, Waters KM, Moorman NJ, Baric RS, Graham RL. Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection. Iscience. 26: 106780. PMID 37193127 DOI: 10.1016/j.isci.2023.106780  0.653
2023 Young E, Yount B, Pantoja P, Henein S, Meganck RM, McBride J, Munt JE, Baric TJ, Zhu D, Scobey T, Dong S, Tse LV, Martinez MI, Burgos AG, Graham RL, et al. A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity. Nature Communications. 14: 1371. PMID 36914616 DOI: 10.1038/s41467-023-36702-x  0.314
2021 Schäfer A, Gralinski LE, Leist SR, Winkler ES, Hampton BK, Mooney MA, Jensen KL, Graham RL, Agnihothram S, Jeng S, Chamberlin S, Bell TA, Scobey DT, VanBlargan LA, Thackray LB, et al. Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species. Biorxiv : the Preprint Server For Biology. PMID 34013261 DOI: 10.1101/2021.05.14.444205  0.318
2021 Alzhanova D, Corcoran K, Bailey AG, Long K, Taft-Benz S, Graham RL, Broussard GS, Heise M, Neumann G, Halfmann P, Kawaoka Y, Baric RS, Damania B, Dittmer DP. Novel modulators of p53-signaling encoded by unknown genes of emerging viruses. Plos Pathogens. 17: e1009033. PMID 33411764 DOI: 10.1371/journal.ppat.1009033  0.425
2020 Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, et al. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science (New York, N.Y.). PMID 33184236 DOI: 10.1126/science.abe8499  0.452
2020 Edwards CE, Yount BL, Graham RL, Leist SR, Hou YJ, Dinnon KH, Sims AC, Swanstrom J, Gully K, Scobey TD, Cooley MR, Currie CG, Randell SH, Baric RS. Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 33046644 DOI: 10.1073/pnas.2001046117  0.69
2020 Mallory ML, Lindesmith LC, Brewer-Jensen PD, Graham RL, Baric RS. Bile Facilitates Human Norovirus Interactions with Diverse Histoblood Group Antigens, Compensating for Capsid Microvariation Observed in 2016-2017 GII.2 Strains. Viruses. 12. PMID 32899556 DOI: 10.3390/V12090989  0.358
2020 Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... Graham RL, et al. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Reports. 107940. PMID 32668216 DOI: 10.1016/J.Celrep.2020.107940  0.715
2020 Sanders W, Fritch EJ, Madden EA, Graham RL, Vincent HA, Heise MT, Baric RS, Moorman NJ. Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses. Biorxiv : the Preprint Server For Biology. PMID 32587967 DOI: 10.1101/2020.06.15.153197  0.373
2020 Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... Graham RL, et al. Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. Biorxiv : the Preprint Server For Biology. PMID 32511392 DOI: 10.1101/2020.04.27.064279  0.693
2020 Graham RL, Baric RS. SARS-CoV-2: Combating Coronavirus Emergence. Immunity. PMID 32392464 DOI: 10.1016/J.Immuni.2020.04.016  0.447
2020 Tse LV, Meganck RM, Graham RL, Baric RS. The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses. Frontiers in Microbiology. 11: 658. PMID 32390971 DOI: 10.3389/Fmicb.2020.00658  0.395
2020 Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine. PMID 32253226 DOI: 10.1126/Scitranslmed.Abb5883  0.767
2020 Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology. PMID 31996437 DOI: 10.1128/Jvi.00127-20  0.415
2019 Menachery VD, Dinnon KH, Yount BL, McAnarney ET, Gralinski LE, Hale A, Graham RL, Scobey T, Anthony SJ, Wang L, Graham B, Randell SH, Lipkin WI, Baric RS. Trypsin treatment unlocks barrier for zoonotic bat coronaviruses infection. Journal of Virology. PMID 31801868 DOI: 10.1128/Jvi.01774-19  0.44
2019 Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Research. 104541. PMID 31233808 DOI: 10.1016/J.Antiviral.2019.104541  0.771
2019 Mallory ML, Lindesmith LC, Graham RL, Baric RS. GII.4 Human Norovirus: Surveying the Antigenic Landscape. Viruses. 11. PMID 30791623 DOI: 10.3390/V11020177  0.378
2018 Gallichotte EN, Baric TJ, Nivarthi U, Delacruz MJ, Graham R, Widman DG, Yount BL, Durbin AP, Whitehead SS, de Silva AM, Baric RS. Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization. Cell Reports. 25: 1214-1224. PMID 30380413 DOI: 10.1016/J.Celrep.2018.10.006  0.414
2018 Lindesmith LC, Brewer-Jensen PD, Mallory ML, Yount B, Collins MH, Debbink K, Graham RL, Baric RS. Human norovirus epitope D plasticity allows escape from antibody immunity without loss of capacity for binding cellular ligands. Journal of Virology. PMID 30355694 DOI: 10.1128/Jvi.01813-18  0.307
2018 Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF. A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques. Scientific Reports. 8: 10727. PMID 30013082 DOI: 10.1038/S41598-018-28900-1  0.341
2018 Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF. A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques. Scientific Reports. 8: 10727. PMID 30013082 DOI: 10.1038/S41598-018-28900-1  0.341
2018 Kocher JF, Lindesmith LC, Debbink K, Beall A, Mallory ML, Yount BL, Graham RL, Huynh J, Gates JE, Donaldson EF, Baric RS. Bat Caliciviruses and Human Noroviruses Are Antigenically Similar and Have Overlapping Histo-Blood Group Antigen Binding Profiles. Mbio. 9. PMID 29789360 DOI: 10.1128/Mbio.00869-18  0.449
2018 Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Mbio. 9. PMID 29511076 DOI: 10.1128/Mbio.00221-18  0.77
2017 Johnson BA, Graham RL, Menachery VD. Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses. Virology. PMID 29279138 DOI: 10.1016/J.Virol.2017.12.009  0.404
2017 Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS. Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis. Msphere. 2. PMID 29152578 DOI: 10.1128/mSphere.00346-17  0.702
2017 Di H, Madden JC, Morantz EK, Tang HY, Graham RL, Baric RS, Brinton MA. Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus. Proceedings of the National Academy of Sciences of the United States of America. 114: E8895-E8904. PMID 29073030 DOI: 10.1073/Pnas.1706696114  0.419
2017 Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K, Kocher JF, Hale AE, Stratton KG, Waters KM, et al. MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis. Mbio. 8. PMID 28830941 DOI: 10.1128/Mbio.00665-17  0.538
2017 Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine. 9. PMID 28659436 DOI: 10.1126/Scitranslmed.Aal3653  0.774
2017 Menachery VD, Graham RL, Baric RS. Jumping species-a mechanism for coronavirus persistence and survival. Current Opinion in Virology. 23: 1-7. PMID 28214731 DOI: 10.1016/J.Coviro.2017.01.002  0.358
2016 Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nature Medicine. 22: 446. PMID 27050591 DOI: 10.1038/Nm0416-446D  0.302
2016 Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, et al. SARS-like WIV1-CoV poised for human emergence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976607 DOI: 10.1073/Pnas.1517719113  0.707
2015 Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nature Medicine. PMID 26552008 DOI: 10.1038/Nm.3985  0.581
2014 Tang XC, Agnihothram SS, Jiao Y, Stanhope J, Graham RL, Peterson EC, Avnir Y, Tallarico AS, Sheehan J, Zhu Q, Baric RS, Marasco WA. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proceedings of the National Academy of Sciences of the United States of America. 111: E2018-26. PMID 24778221 DOI: 10.1073/Pnas.1402074111  0.478
2014 Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, et al. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. Mbio. 5: e00047-14. PMID 24667706 DOI: 10.1128/Mbio.00047-14  0.698
2014 Freeman MC, Graham RL, Lu X, Peek CT, Denison MR. Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. Journal of Virology. 88: 5319-27. PMID 24623413 DOI: 10.1128/Jvi.00021-14  0.706
2014 Agnihothram S, Gopal R, Yount BL, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. The Journal of Infectious Diseases. 209: 995-1006. PMID 24253287 DOI: 10.1093/Infdis/Jit609  0.685
2013 Graham RL, Donaldson EF, Baric RS. A decade after SARS: strategies for controlling emerging coronaviruses. Nature Reviews. Microbiology. 11: 836-48. PMID 24217413 DOI: 10.1038/Nrmicro3143  0.404
2013 Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proceedings of the National Academy of Sciences of the United States of America. 110: 16157-62. PMID 24043791 DOI: 10.1073/Pnas.1311542110  0.746
2013 Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. Mbio. 4: e00165-13. PMID 23631916 DOI: 10.1128/Mbio.00165-13  0.478
2012 Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nature Medicine. 18: 1820-6. PMID 23142821 DOI: 10.1038/Nm.2972  0.709
2011 Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. Rna Biology. 8: 270-9. PMID 21593585 DOI: 10.4161/Rna.8.2.15013  0.684
2010 Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. Plos Pathogens. 6: e1000896. PMID 20463816 DOI: 10.1371/Journal.Ppat.1000896  0.704
2010 Graham RL, Baric RS. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. Journal of Virology. 84: 3134-46. PMID 19906932 DOI: 10.1128/Jvi.01394-09  0.469
2008 Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 19944-9. PMID 19036930 DOI: 10.1073/Pnas.0808116105  0.762
2008 Gadlage MJ, Graham RL, Denison MR. Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. Journal of Virology. 82: 11964-9. PMID 18815297 DOI: 10.1128/Jvi.01126-07  0.669
2008 Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. SARS coronavirus replicase proteins in pathogenesis. Virus Research. 133: 88-100. PMID 17397959 DOI: 10.1016/J.Virusres.2007.02.017  0.781
2007 Deming DJ, Graham RL, Denison MR, Baric RS. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. Journal of Virology. 81: 10280-91. PMID 17634238 DOI: 10.1128/Jvi.00017-07  0.715
2007 Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. Journal of Virology. 81: 7086-98. PMID 17428870 DOI: 10.1128/Jvi.00049-07  0.779
2007 Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. Journal of Virology. 81: 6356-68. PMID 17392363 DOI: 10.1128/Jvi.02805-06  0.8
2006 Deming DJ, Graham RL, Denison MR, Baric RS. MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication. Advances in Experimental Medicine and Biology. 581: 101-4. PMID 17037513 DOI: 10.1007/978-0-387-33012-9_17  0.634
2006 Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Advances in Experimental Medicine and Biology. 581: 67-72. PMID 17037506 DOI: 10.1007/978-0-387-33012-9_10  0.778
2006 Graham RL, Denison MR. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. Journal of Virology. 80: 11610-20. PMID 16971428 DOI: 10.1128/Jvi.01428-06  0.701
2005 Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. Journal of Virology. 79: 13399-411. PMID 16227261 DOI: 10.1128/Jvi.79.21.13399-13411.2005  0.81
2005 Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. Journal of Virology. 79: 3391-400. PMID 15731233 DOI: 10.1128/Jvi.79.6.3391-3400.2005  0.695
2004 Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. Journal of Virology. 78: 5957-65. PMID 15140993 DOI: 10.1128/Jvi.78.11.5957-5965.2004  0.764
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