| Year |
Citation |
Score |
| 2025 |
Grimes SL, Heaton BE, Anderson ML, Burke K, Stevens L, Lu X, Heaton NS, Denison MR, Anderson-Daniels J. The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity. Journal of Virology. e0170824. PMID 39791922 DOI: 10.1128/jvi.01708-24 |
0.489 |
|
| 2024 |
Abiona OM, Wang N, Leist SR, Schäfer A, Cockrell AS, Wang L, Bangaru S, Stevens L, Graham RL, Kocher JF, Tsybovsky Y, Kanekiyo M, Kumar A, Morabito KM, Rosen O, ... ... Denison MR, et al. MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies. Iscience. 28: 111632. PMID 39898019 DOI: 10.1016/j.isci.2024.111632 |
0.496 |
|
| 2024 |
Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, ... ... Denison MR, et al. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Reports. 43: 114929. PMID 39504242 DOI: 10.1016/j.celrep.2024.114929 |
0.581 |
|
| 2024 |
Grimes SL, Heaton BE, Anderson ML, Burke K, Stevens L, Lu X, Heaton NS, Denison MR, Anderson-Daniels J. The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity. Biorxiv : the Preprint Server For Biology. PMID 39386528 DOI: 10.1101/2024.09.26.615217 |
0.454 |
|
| 2024 |
Grimes SL, Denison MR. The Coronavirus helicase in replication. Virus Research. 346: 199401. PMID 38796132 DOI: 10.1016/j.virusres.2024.199401 |
0.379 |
|
| 2023 |
Grimes SL, Choi YJ, Banerjee A, Small G, Anderson-Daniels J, Gribble J, Pruijssers AJ, Agostini ML, Abu-Shmais A, Lu X, Darst SA, Campbell E, Denison MR. A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance. Mbio. e0106023. PMID 37338298 DOI: 10.1128/mbio.01060-23 |
0.4 |
|
| 2023 |
Cable J, Denison MR, Kielian M, Jackson WT, Bartenschlager R, Ahola T, Mukhopadhyay S, Fremont DH, Kuhn RJ, Shannon A, Frazier MN, Yuen KY, Coyne CB, Wolthers KC, Ming GL, et al. Positive-strand RNA viruses-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 36697369 DOI: 10.1111/nyas.14957 |
0.367 |
|
| 2022 |
Anderson-Daniels J, Gribble J, Denison M. Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness. Journal of Virology. 96: e0084122. PMID 35924922 DOI: 10.1128/jvi.00841-22 |
0.505 |
|
| 2022 |
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, ... ... Denison MR, et al. Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. Science Translational Medicine. eabo0718. PMID 35482820 DOI: 10.1126/scitranslmed.abo0718 |
0.376 |
|
| 2021 |
Smith SC, Gribble J, Diller JR, Wiebe MA, Thoner TW, Denison MR, Ogden KM. Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage. Journal of Virology. PMID 33472930 DOI: 10.1128/JVI.02181-20 |
0.369 |
|
| 2021 |
Gribble J, Stevens LJ, Agostini ML, Anderson-Daniels J, Chappell JD, Lu X, Pruijssers AJ, Routh AL, Denison MR. The coronavirus proofreading exoribonuclease mediates extensive viral recombination. Plos Pathogens. 17: e1009226. PMID 33465137 DOI: 10.1371/journal.ppat.1009226 |
0.457 |
|
| 2020 |
Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, ... ... Denison MR, et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. PMID 32756549 DOI: 10.1038/S41586-020-2622-0 |
0.352 |
|
| 2020 |
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... ... Denison MR, et al. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Reports. 107940. PMID 32668216 DOI: 10.1016/J.Celrep.2020.107940 |
0.683 |
|
| 2020 |
Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... ... Denison MR, et al. Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. Biorxiv : the Preprint Server For Biology. PMID 32511392 DOI: 10.1101/2020.04.27.064279 |
0.652 |
|
| 2020 |
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, ... ... Denison MR, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine. PMID 32253226 DOI: 10.1126/Scitranslmed.Abb5883 |
0.764 |
|
| 2020 |
Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, ... ... Denison MR, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nature Communications. 11: 222. PMID 31924756 DOI: 10.1038/S41467-019-13940-6 |
0.677 |
|
| 2019 |
Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, ... Denison MR, et al. Small molecule antiviral β-D--hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of Virology. PMID 31578288 DOI: 10.1128/Jvi.01348-19 |
0.723 |
|
| 2019 |
Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, et al. Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Reports. 28: 3395-3405.e6. PMID 31553909 DOI: 10.1016/J.Celrep.2019.08.052 |
0.342 |
|
| 2019 |
Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR. Fitness barriers limit reversion of a proofreading-deficient coronavirus. Journal of Virology. PMID 31341046 DOI: 10.1128/Jvi.00711-19 |
0.468 |
|
| 2019 |
Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Research. 104541. PMID 31233808 DOI: 10.1016/J.Antiviral.2019.104541 |
0.765 |
|
| 2019 |
Pruijssers AJ, Denison MR. Nucleoside analogues for the treatment of coronavirus infections. Current Opinion in Virology. 35: 57-62. PMID 31125806 DOI: 10.1016/J.Coviro.2019.04.002 |
0.443 |
|
| 2018 |
Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. Mbio. 9. PMID 29717007 DOI: 10.1128/Mbio.00272-18 |
0.506 |
|
| 2018 |
Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, ... ... Denison MR, et al. Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape. Journal of Virology. PMID 29514901 DOI: 10.1128/JVI.02002-17 |
0.406 |
|
| 2018 |
Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, ... ... Denison MR, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Mbio. 9. PMID 29511076 DOI: 10.1128/Mbio.00221-18 |
0.767 |
|
| 2017 |
Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR. Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations. Mbio. 8. PMID 29114026 DOI: 10.1128/Mbio.01503-17 |
0.544 |
|
| 2017 |
Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR. Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity. Journal of Virology. PMID 29046453 DOI: 10.1128/Jvi.01531-17 |
0.521 |
|
| 2017 |
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, et al. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proceedings of the National Academy of Sciences of the United States of America. PMID 28807998 DOI: 10.1073/Pnas.1707304114 |
0.344 |
|
| 2017 |
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, ... ... Denison MR, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine. 9. PMID 28659436 DOI: 10.1126/Scitranslmed.Aal3653 |
0.762 |
|
| 2017 |
Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. Mbio. 8. PMID 28143984 DOI: 10.1128/Mbio.02320-16 |
0.564 |
|
| 2017 |
Jordan R, Hogg A, Warren T, De Wit E, Sheahan T, Lo M, Soloveva V, Weidner J, Gomba L, Feldmann F, Cronin J, Sims A, Cockrell A, Feng J, Trantcheva I, ... ... Denison M, et al. Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential Open Forum Infectious Diseases. 4: S737-S737. DOI: 10.1093/Ofid/Ofx180.008 |
0.711 |
|
| 2016 |
Mounce BC, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke SW, Smith EC, Poirier EZ, Simon-Loriere E, Prot M, Tamietti C, Vitry S, Volle R, Khou C, Frenkiel MP, ... ... Denison MR, et al. Inhibition of polyamine biosynthesis is a broad-spectrum strategy against RNA viruses. Journal of Virology. PMID 27535047 DOI: 10.1128/Jvi.01347-16 |
0.544 |
|
| 2016 |
Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen O, Denison MR. Homology-based identification of a mutation in the coronavirus RNA-dependent RNA polymerase that confers resistance to multiple mutagens. Journal of Virology. PMID 27279608 DOI: 10.1128/Jvi.00080-16 |
0.5 |
|
| 2016 |
Case JB, Ashbrook AW, Dermody TS, Denison MR. Mutagenesis of S-adenosyl-L-methionine-binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity. Journal of Virology. PMID 27252528 DOI: 10.1128/Jvi.00542-16 |
0.544 |
|
| 2015 |
Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, ... ... Denison MR, et al. Evaluation of candidate vaccine approaches for MERS-CoV. Nature Communications. 6: 7712. PMID 26218507 DOI: 10.1038/Ncomms8712 |
0.364 |
|
| 2015 |
Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS. Serotonin Receptor Agonist 5-nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. Journal of Virology. PMID 26109733 DOI: 10.1128/Jvi.00739-15 |
0.46 |
|
| 2015 |
Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Ligand-induced dimerization of MERS coronavirus nsp5 protease (3CLpro): implications for nsp5 regulation and the development of antivirals. The Journal of Biological Chemistry. PMID 26055715 DOI: 10.1074/Jbc.M115.651463 |
0.354 |
|
| 2015 |
Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. Journal of Virology. 89: 6418-26. PMID 25855750 DOI: 10.1128/Jvi.00110-15 |
0.526 |
|
| 2015 |
Beachboard DC, Anderson-Daniels JM, Denison MR. Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications. Journal of Virology. 89: 2080-9. PMID 25473044 DOI: 10.1128/Jvi.02776-14 |
0.559 |
|
| 2015 |
Osadebe LU, Manthiram K, McCollum AM, Li Y, Emerson GL, Gallardo-Romero NF, Doty JB, Wilkins K, Zhao H, Drew CP, Metcalfe MG, Goldsmith CS, Muehlenbachs A, Googe PB, Dunn J, ... ... Denison MR, et al. Novel poxvirus infection in 2 patients from the United States. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 60: 195-202. PMID 25301210 DOI: 10.1093/Cid/Ciu790 |
0.309 |
|
| 2014 |
Smith EC, Sexton NR, Denison MR. Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses. Annual Review of Virology. 1: 111-32. PMID 26958717 DOI: 10.1146/Annurev-Virology-031413-085507 |
0.481 |
|
| 2014 |
Freeman MC, Peek CT, Becker MM, Smith EC, Denison MR. Coronaviruses induce entry-independent, continuous macropinocytosis. Mbio. 5: e01340-14. PMID 25096879 DOI: 10.1128/Mbio.01340-14 |
0.546 |
|
| 2014 |
Agnihothram S, Yount BL, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, ... ... Denison MR, et al. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. Mbio. 5: e00047-14. PMID 24667706 DOI: 10.1128/Mbio.00047-14 |
0.669 |
|
| 2014 |
Freeman MC, Graham RL, Lu X, Peek CT, Denison MR. Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation. Journal of Virology. 88: 5319-27. PMID 24623413 DOI: 10.1128/Jvi.00021-14 |
0.727 |
|
| 2014 |
Khuri-Bulos N, Payne DC, Lu X, Erdman D, Wang L, Faouri S, Shehabi A, Johnson M, Becker MM, Denison MR, Williams JV, Halasa NB. Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 20: 678-82. PMID 24313317 DOI: 10.1111/1469-0691.12438 |
0.313 |
|
| 2014 |
Agnihothram S, Gopal R, Yount BL, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. The Journal of Infectious Diseases. 209: 995-1006. PMID 24253287 DOI: 10.1093/Infdis/Jit609 |
0.649 |
|
| 2013 |
Smith EC, Denison MR. Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity. Plos Pathogens. 9: e1003760. PMID 24348241 DOI: 10.1371/Journal.Ppat.1003760 |
0.507 |
|
| 2013 |
Stobart CC, Sexton NR, Munjal H, Lu X, Molland KL, Tomar S, Mesecar AD, Denison MR. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. Journal of Virology. 87: 12611-8. PMID 24027335 DOI: 10.1128/Jvi.02050-13 |
0.529 |
|
| 2013 |
Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. Plos Pathogens. 9: e1003565. PMID 23966862 DOI: 10.1371/Journal.Ppat.1003565 |
0.553 |
|
| 2013 |
Beachboard DC, Lu X, Baker SC, Denison MR. Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive. Virology. 435: 210-3. PMID 23099203 DOI: 10.1016/J.Virol.2012.10.001 |
0.525 |
|
| 2012 |
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS. A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease. Nature Medicine. 18: 1820-6. PMID 23142821 DOI: 10.1038/Nm.2972 |
0.683 |
|
| 2012 |
Smith EC, Denison MR. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Current Opinion in Virology. 2: 519-24. PMID 22857992 DOI: 10.1016/J.Coviro.2012.07.005 |
0.546 |
|
| 2012 |
Stobart CC, Lee AS, Lu X, Denison MR. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity. Journal of Virology. 86: 4801-10. PMID 22345451 DOI: 10.1128/Jvi.06754-11 |
0.422 |
|
| 2011 |
Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. Rna Biology. 8: 270-9. PMID 21593585 DOI: 10.4161/Rna.8.2.15013 |
0.698 |
|
| 2011 |
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, ... Denison MR, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. Plos Pathogens. 7: e1001258. PMID 21253575 DOI: 10.1371/Journal.Ppat.1001258 |
0.543 |
|
| 2011 |
Frangoul H, Domm J, Denison MR, Calder C, Black J. H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT Bone Marrow Transplantation. 46: 152-153. PMID 20383217 DOI: 10.1038/Bmt.2010.66 |
0.313 |
|
| 2010 |
Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. Plos Pathogens. 6: e1000896. PMID 20463816 DOI: 10.1371/Journal.Ppat.1000896 |
0.675 |
|
| 2010 |
Gadlage MJ, Denison MR. Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. Journal of Virology. 84: 6894-8. PMID 20427532 DOI: 10.1128/Jvi.00752-10 |
0.416 |
|
| 2010 |
Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD. Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 50: 1493-6. PMID 20415572 DOI: 10.1086/652655 |
0.388 |
|
| 2010 |
Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR. Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. Journal of Virology. 84: 280-90. PMID 19846526 DOI: 10.1128/Jvi.01772-09 |
0.555 |
|
| 2008 |
Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 19944-9. PMID 19036930 DOI: 10.1073/Pnas.0808116105 |
0.749 |
|
| 2008 |
Denison MR. Seeking membranes: positive-strand RNA virus replication complexes. Plos Biology. 6: e270. PMID 18959488 DOI: 10.1371/Journal.Pbio.0060270 |
0.515 |
|
| 2008 |
Gadlage MJ, Graham RL, Denison MR. Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. Journal of Virology. 82: 11964-9. PMID 18815297 DOI: 10.1128/Jvi.01126-07 |
0.665 |
|
| 2008 |
Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. Journal of Virology. 82: 5999-6008. PMID 18385240 DOI: 10.1128/Jvi.00203-08 |
0.51 |
|
| 2008 |
Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. SARS coronavirus replicase proteins in pathogenesis. Virus Research. 133: 88-100. PMID 17397959 DOI: 10.1016/J.Virusres.2007.02.017 |
0.797 |
|
| 2007 |
Sparks JS, Lu X, Denison MR. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. Journal of Virology. 81: 12554-63. PMID 17855548 DOI: 10.1128/Jvi.01257-07 |
0.595 |
|
| 2007 |
Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. Journal of Virology. 81: 12135-44. PMID 17804504 DOI: 10.1128/Jvi.01296-07 |
0.556 |
|
| 2007 |
Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW. Coronavirus replication does not require the autophagy gene ATG5. Autophagy. 3: 581-5. PMID 17700057 DOI: 10.4161/Auto.4782 |
0.521 |
|
| 2007 |
Deming DJ, Graham RL, Denison MR, Baric RS. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. Journal of Virology. 81: 10280-91. PMID 17634238 DOI: 10.1128/Jvi.00017-07 |
0.727 |
|
| 2007 |
Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. Journal of Virology. 81: 7086-98. PMID 17428870 DOI: 10.1128/Jvi.00049-07 |
0.791 |
|
| 2007 |
Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis. Journal of Virology. 81: 6356-68. PMID 17392363 DOI: 10.1128/Jvi.02805-06 |
0.81 |
|
| 2006 |
Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS. SARS coronavirus accessory ORFs encode luxury functions. Advances in Experimental Medicine and Biology. 581: 149-52. PMID 17037522 DOI: 10.1007/978-0-387-33012-9_26 |
0.745 |
|
| 2006 |
Deming DJ, Graham RL, Denison MR, Baric RS. MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication. Advances in Experimental Medicine and Biology. 581: 101-4. PMID 17037513 DOI: 10.1007/978-0-387-33012-9_17 |
0.679 |
|
| 2006 |
Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Advances in Experimental Medicine and Biology. 581: 67-72. PMID 17037506 DOI: 10.1007/978-0-387-33012-9_10 |
0.798 |
|
| 2006 |
Eckerle LD, Brockway SM, Sperry SM, Lu X, Denison MR. Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Advances in Experimental Medicine and Biology. 581: 55-60. PMID 17037504 DOI: 10.1007/978-0-387-33012-9_8 |
0.516 |
|
| 2006 |
Graham RL, Denison MR. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. Journal of Virology. 80: 11610-20. PMID 16971428 DOI: 10.1128/Jvi.01428-06 |
0.692 |
|
| 2005 |
Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS. Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. Journal of Virology. 79: 14909-22. PMID 16282490 DOI: 10.1128/Jvi.79.23.14909-14922.2005 |
0.739 |
|
| 2005 |
Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. Journal of Virology. 79: 13399-411. PMID 16227261 DOI: 10.1128/Jvi.79.21.13399-13411.2005 |
0.822 |
|
| 2005 |
Brockway SM, Denison MR. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology. 340: 209-23. PMID 16051301 DOI: 10.1016/J.Virol.2005.06.035 |
0.596 |
|
| 2005 |
Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. Journal of Virology. 79: 3391-400. PMID 15731233 DOI: 10.1128/Jvi.79.6.3391-3400.2005 |
0.692 |
|
| 2004 |
Brockway SM, Denison MR. Molecular targets for the rational design of drugs to inhibit SARS coronavirus. Drug Discovery Today. Disease Mechanisms. 1: 205-209. PMID 32288772 DOI: 10.1016/J.Ddmec.2004.08.016 |
0.366 |
|
| 2004 |
Denison MR. Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. The Pediatric Infectious Disease Journal. 23: S207-14. PMID 15577575 DOI: 10.1097/01.Inf.0000144666.95284.05 |
0.415 |
|
| 2004 |
Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. Journal of Virology. 78: 11551-62. PMID 15479796 DOI: 10.1128/Jvi.78.21.11551-11562.2004 |
0.471 |
|
| 2004 |
Prentice E, McAuliffe J, Lu X, Subbarao K, Denison MR. Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. Journal of Virology. 78: 9977-86. PMID 15331731 DOI: 10.1128/Jvi.78.18.9977-9986.2004 |
0.747 |
|
| 2004 |
Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. Journal of Virology. 78: 5957-65. PMID 15140993 DOI: 10.1128/Jvi.78.11.5957-5965.2004 |
0.783 |
|
| 2004 |
Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. The Journal of Biological Chemistry. 279: 10136-41. PMID 14699140 DOI: 10.1074/Jbc.M306124200 |
0.721 |
|
| 2003 |
Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proceedings of the National Academy of Sciences of the United States of America. 100: 12995-3000. PMID 14569023 DOI: 10.1073/Pnas.1735582100 |
0.709 |
|
| 2003 |
Brockway SM, Clay CT, Lu XT, Denison MR. Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. Journal of Virology. 77: 10515-27. PMID 12970436 DOI: 10.1128/Jvi.77.19.10515-10527.2003 |
0.576 |
|
| 2002 |
Yount B, Denison MR, Weiss SR, Baric RS. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. Journal of Virology. 76: 11065-78. PMID 12368349 DOI: 10.1128/Jvi.76.21.11065-11078.2002 |
0.493 |
|
| 2001 |
Denison MR, Sims AC. MHV-A59 gene 1 proteins are associated with two distinct membrane populations. Advances in Experimental Medicine and Biology. 494: 655-61. PMID 11774541 DOI: 10.1007/978-1-4615-1325-4_97 |
0.683 |
|
| 2001 |
Prentice E, Denison MR. The cell biology of coronavirus infection. Advances in Experimental Medicine and Biology. 494: 609-14. PMID 11774533 DOI: 10.1007/978-1-4615-1325-4_90 |
0.729 |
|
| 2001 |
Bost AG, Prentice E, Denison MR. Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology. 285: 21-9. PMID 11414802 DOI: 10.1006/Viro.2001.0932 |
0.787 |
|
| 2000 |
Sims AC, Ostermann J, Denison MR. Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. Journal of Virology. 74: 5647-54. PMID 10823872 DOI: 10.1128/Jvi.74.12.5647-5654.2000 |
0.746 |
|
| 2000 |
Bost AG, Carnahan RH, Lu XT, Denison MR. Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. Journal of Virology. 74: 3379-87. PMID 10708455 DOI: 10.1128/Jvi.74.7.3379-3387.2000 |
0.812 |
|
| 1999 |
Van Der Meer Y, Snijder EJ, Dobbe JC, Schleich S, Denison MR, Spaan WJM, Locker JK. Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication Journal of Virology. 73: 7641-7657. PMID 10438855 DOI: 10.1128/Jvi.73.9.7641-7657.1999 |
0.579 |
|
| 1999 |
Denison MR, Spaan WJ, van der Meer Y, Gibson CA, Sims AC, Prentice E, Lu XT. The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. Journal of Virology. 73: 6862-71. PMID 10400784 DOI: 10.1128/Jvi.73.8.6862-6871.1999 |
0.821 |
|
| 1998 |
Gibson CA, Chen J, Monroe SA, Denison MR. Expression and processing of nonstructural proteins of the human astroviruses Advances in Experimental Medicine and Biology. 440: 387-391. PMID 9782307 DOI: 10.1007/978-1-4615-5331-1_50 |
0.468 |
|
| 1998 |
Sims AC, Lu XT, Denison MR. Expression, purification, and activity of recombinant MHV-A59 3CLpro. Advances in Experimental Medicine and Biology. 440: 129-34. PMID 9782274 DOI: 10.1007/978-1-4615-5331-1_17 |
0.671 |
|
| 1998 |
Denison MR, Sims AC, Gibson CA, Lu XT. Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Advances in Experimental Medicine and Biology. 440: 121-7. PMID 9782273 DOI: 10.1007/978-1-4615-5331-1_16 |
0.685 |
|
| 1998 |
Lu XT, Sims AC, Denison MR. Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. Journal of Virology. 72: 2265-71. PMID 9499085 DOI: 10.1128/Jvi.72.3.2265-2271.1998 |
0.727 |
|
| 1997 |
Lu Y, Denison MR. Determinants of mouse hepatitis virus 3C-like proteinase activity Virology. 230: 335-342. PMID 9143289 DOI: 10.1006/Viro.1997.8479 |
0.392 |
|
| 1996 |
Lu X, Lu Y, Denison MR. Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59 Virology. 222: 375-382. PMID 8806521 DOI: 10.1006/Viro.1996.0434 |
0.471 |
|
| 1995 |
Denison MR. Viral pharyngitis. Seminars in Pediatric Infectious Diseases. 6: 62-68. PMID 32336899 DOI: 10.1016/S1045-1870(05)80053-6 |
0.405 |
|
| 1995 |
Kim JC, Spence RA, Currier PF, Lu X, Denison MR. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d Virology. 208: 1-8. PMID 11831690 DOI: 10.1006/Viro.1995.1123 |
0.545 |
|
| 1995 |
Denison MR, Kim JC, Ross T. Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors Advances in Experimental Medicine and Biology. 380: 391-397. PMID 8830514 DOI: 10.1007/978-1-4615-1899-0_64 |
0.524 |
|
| 1995 |
Denison MR, Hughes SA, Weiss SR. Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology. 207: 316-20. PMID 7871746 DOI: 10.1006/Viro.1995.1085 |
0.447 |
|
| 1995 |
Lu Y, Lu X, Denison MR. Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59 Journal of Virology. 69: 3554-3559. PMID 7745703 DOI: 10.1128/Jvi.69.6.3554-3559.1995 |
0.432 |
|
| 1995 |
Denison MR. Viral pharyngitis Seminars in Pediatric Infectious Diseases. 6: 62-68. DOI: 10.1016/S1045-1870(05)80053-6 |
0.405 |
|
| 1994 |
Weiss SR, Hughes SA, Bonilla PJ, Turner JD, Leibowitz JL, Denison MR. Coronavirus polyprotein processing. Archives of Virology. Supplementum. 9: 349-58. PMID 8032266 DOI: 10.1007/978-3-7091-9326-6_35 |
0.446 |
|
| 1993 |
Hughes SA, Denison MR, Bonilla P, Leibowitz JL, Baric RS, Weiss SR. A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Advances in Experimental Medicine and Biology. 342: 221-6. PMID 8209734 DOI: 10.1007/978-1-4615-2996-5_35 |
0.431 |
|
| 1992 |
Denison MR, Zoltick PW, Hughes SA, Giangreco B, Olson AL, Perlman S, Leibowitz JL, Weiss SR. Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology. 189: 274-84. PMID 1318604 DOI: 10.1016/0042-6822(92)90703-R |
0.419 |
|
| 1991 |
Denison MR, Zoltick PW, Leibowitz JL, Pachuk CJ, Weiss SR. Identification of Polypeptides Encoded in Open Reading Frame 1b of the Putative Polymerase Gene of the Murine Coronavirus Mouse Hepatitis Virus A59 Journal of Virology. 65: 3076-3082. PMID 2033667 DOI: 10.1128/Jvi.65.6.3076-3082.1991 |
0.472 |
|
| 1987 |
Denison M, Perlman S. Identification of putative polymerase gene product in cells infected with murine coronavirus A59 Virology. 157: 565-568. PMID 3029990 DOI: 10.1016/0042-6822(87)90303-5 |
0.513 |
|
| 1987 |
Denison M, Perlman S. Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells Advances in Experimental Medicine and Biology. 218: 155-156. PMID 2829524 DOI: 10.1007/978-1-4684-1280-2_18 |
0.481 |
|
| 1986 |
Denison MR, Perlman S. Translation and processing of mouse hepatitis virus virion RNA in a cell-free system Journal of Virology. 60: 12-18. PMID 3018279 DOI: 10.1128/Jvi.60.1.12-18.1986 |
0.511 |
|
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