Adam Zlotnick - Publications

Affiliations: 
Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Virus structure, virus assembly, biophysics, structural biology

159 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hussain T, Zhao Z, Murphy B, Taylor ZE, Gudorf JA, Klein S, Barnes LF, VanNieuwenhze M, Jarrold MF, Zlotnick A. Chemically Tagging Cargo for Specific Packaging inside and on the Surface of Virus-like Particles. Acs Nano. PMID 39087909 DOI: 10.1021/acsnano.4c02056  0.829
2024 Khaykelson D, Asor R, Zhao Z, Schlicksup CJ, Zlotnick A, Raviv U. Guanidine Hydrochloride-Induced Hepatitis B Virus Capsid Disassembly Hysteresis. Biochemistry. PMID 38787909 DOI: 10.1021/acs.biochem.4c00077  0.861
2024 Yang R, Ko YH, Li F, Lokareddy RK, Hou CD, Kim C, Klein S, Antolínez S, Marín JF, Pérez-Segura C, Jarrold MF, Zlotnick A, Hadden-Perilla JA, Cingolani G. Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Science Advances. 10: eadi7606. PMID 38198557 DOI: 10.1126/sciadv.adi7606  0.417
2023 Kim C, Schlicksup CJ, Pérez-Segura C, Hadden-Perilla JA, Che-Yen Wang J, Zlotnick A. Structure of the Hepatitis B Virus capsid quasi-sixfold with a trapped C-terminal domain reveals capsid movements associated with domain exit. The Journal of Biological Chemistry. 105104. PMID 37517693 DOI: 10.1016/j.jbc.2023.105104  0.827
2023 Zlotnick A, Nair S, Katen SP. New tricks for old molecules: A newly discovered modality for CAMs may yet lead to an HBV cure. Hepatology (Baltimore, Md.). PMID 37368996 DOI: 10.1097/HEP.0000000000000522  0.769
2023 Starr CA, Nair S, Huang SY, Hagan MF, Jacobson SC, Zlotnick A. Engineering Metastability into a Virus-like Particle to Enable Triggered Dissociation. Journal of the American Chemical Society. PMID 36651799 DOI: 10.1021/jacs.2c10937  0.432
2022 Castón JR, Zlotnick A. Editorial overview: Virus structure and expression. Current Opinion in Virology. 57: 101277. PMID 36327658 DOI: 10.1016/j.coviro.2022.101277  0.326
2022 Zoulim F, Zlotnick A, Buchholz S, Donaldson E, Fry J, Gaggar A, Hu J, Kann M, Lenz O, Lin K, Mani N, Nassal M, Delaney W, Wang S, Westman G, et al. Nomenclature of HBV core protein-targeting antivirals. Nature Reviews. Gastroenterology & Hepatology. PMID 36207612 DOI: 10.1038/s41575-022-00700-z  0.329
2022 Mohajerani F, Tyukodi B, Schlicksup CJ, Hadden-Perilla JA, Zlotnick A, Hagan MF. Multiscale Modeling of Hepatitis B Virus Capsid Assembly and Its Dimorphism. Acs Nano. PMID 36054910 DOI: 10.1021/acsnano.2c02119  0.85
2022 Starr CA, Barnes LF, Jarrold MF, Zlotnick A. Hysteresis in Hepatitis B Virus (HBV) Requires Assembly of Near-Perfect Capsids. Biochemistry. 61: 505-513. PMID 35258283 DOI: 10.1021/acs.biochem.1c00810  0.582
2021 Zhou J, Zlotnick A, Jacobson SC. Disassembly of Single Virus Capsids Monitored in Real Time with Multicycle Resistive-Pulse Sensing. Analytical Chemistry. 94: 985-992. PMID 34932317 DOI: 10.1021/acs.analchem.1c03855  0.434
2021 Buzón P, Maity S, Christodoulis P, Wiertsema MJ, Dunkelbarger S, Kim C, Wuite GJL, Zlotnick A, Roos WH. Virus self-assembly proceeds through contact-rich energy minima. Science Advances. 7: eabg0811. PMID 34730996 DOI: 10.1126/sciadv.abg0811  0.393
2021 Kim C, Barnes LF, Schlicksup CJ, Patterson AJ, Bothner BB, Jarrold MF, Wang CJ, Zlotnick A. Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt HBV Capsids. Journal of Virology. JVI0139521. PMID 34705562 DOI: 10.1128/JVI.01395-21  0.841
2021 Nair S, Zlotnick A. HBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar Compartments. Mbio. 12. PMID 33563815 DOI: 10.1128/mBio.03514-20  0.469
2021 Zhao Z, Wang JC, Zhang M, Lyktey NA, Jarrold MF, Jacobson SC, Zlotnick A. Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry. Nature Communications. 12: 589. PMID 33500404 DOI: 10.1038/s41467-020-20862-1  0.848
2020 Shukla S, Wang C, Beiss V, Cai H, Washington T, Murray AA, Gong X, Zhao Z, Masarapu H, Zlotnick A, Fiering S, Steinmetz NF. The unique potency of Cowpea mosaic virus (CPMV) cancer vaccine. Biomaterials Science. PMID 32914796 DOI: 10.1039/D0Bm01219J  0.781
2020 Todd AR, Barnes LF, Young K, Zlotnick A, Jarrold MF. Higher Resolution Charge Detection Mass Spectrometry. Analytical Chemistry. 92: 11357-11364. PMID 32806905 DOI: 10.1021/Acs.Analchem.0C02133  0.348
2020 Schlicksup CJ, Zlotnick A. Viral structural proteins as targets for antivirals. Current Opinion in Virology. 45: 43-50. PMID 32777753 DOI: 10.1016/J.Coviro.2020.07.001  0.843
2020 Patterson A, Zhao Z, Waymire E, Zlotnick A, Bothner B. Dynamics of Hepatitis B virus capsid protein dimer regulate assembly through an allosteric network. Acs Chemical Biology. PMID 32662972 DOI: 10.1021/Acschembio.0C00481  0.847
2020 van Rosmalen MGM, Kamsma D, Biebricher AS, Li C, Zlotnick A, Roos WH, Wuite GJL. Revealing in real-time a multistep assembly mechanism for SV40 virus-like particles. Science Advances. 6: eaaz1639. PMID 32494611 DOI: 10.1126/Sciadv.Aaz1639  0.741
2020 Zhao Z, Wang JC, Segura CP, Hadden-Perilla JA, Zlotnick A. The integrity of the intradimer interface of the Hepatitis B Virus capsid protein dimer regulates capsid self-assembly. Acs Chemical Biology. PMID 32459465 DOI: 10.1021/Acschembio.0C00277  0.837
2020 Schlicksup CJ, Laughlin P, Dunkelbarger S, Wang JC, Zlotnick A. Local stabilization of subunit-subunit contacts causes global destabilization of Hepatitis B virus capsids. Acs Chemical Biology. PMID 32369333 DOI: 10.1021/Acschembio.0C00320  0.877
2020 Asor R, Schlicksup CJ, Zhao Z, Zlotnick A, Raviv U. Rapidly Forming Early Intermediate Structures Dictate the Pathway of Capsid Assembly. Journal of the American Chemical Society. PMID 32233479 DOI: 10.1021/Jacs.0C01092  0.837
2020 Buzón P, Maity S, Christodoulis P, Wiertsema MJ, Dunkelbarger S, Kim C, Wuite GJ, Zlotnick A, Roos WH. Uncovering the Self-Assembly Mechanism of Hepatitis B Virus at the Single-Molecule Level Biophysical Journal. 118: 200a. DOI: 10.1016/J.Bpj.2019.11.1204  0.563
2019 Asor R, Selzer L, Schlicksup CJ, Zhao Z, Zlotnick A, Raviv U. Assembly Reactions of Hepatitis B Capsid Protein into Capsid Nanoparticles Follow a Narrow Path Through a Complex Reaction Landscape. Acs Nano. PMID 31173689 DOI: 10.1021/Acsnano.9B00648  0.821
2019 Zhao Z, Wang JC, Gonzalez-Gutierrez G, Venkatakrishnan B, Asor R, Khaykelson D, Raviv U, Zlotnick A. Structural differences between the Woodchuck hepatitis virus core protein in dimer and capsid states are consistent with entropic and conformational regulation of assembly. Journal of Virology. PMID 31043524 DOI: 10.1128/Jvi.00141-19  0.882
2019 Kondylis P, Schlicksup CJ, Katen SP, Lee LS, Zlotnick A, Jacobson SC. Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-based Antivirals. Acs Infectious Diseases. PMID 30616343 DOI: 10.1021/Acsinfecdis.8B00290  0.87
2018 Kondylis P, Schlicksup CJ, Brunk NE, Zhou J, Zlotnick A, Jacobson SC. Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle Methods. Journal of the American Chemical Society. PMID 30537810 DOI: 10.1021/Jacs.8B10131  0.848
2018 Kondylis P, Schlicksup CJ, Zlotnick A, Jacobson SC. Analytical Techniques to Characterize the Structure, Properties, and Assembly of Virus Capsids. Analytical Chemistry. PMID 30383361 DOI: 10.1021/Acs.Analchem.8B04824  0.803
2018 Nair S, Li L, Francis S, Turner WW, VanNieuwenhze M, Zlotnick A. Use of a Fluorescent Analogue of a HBV Core Protein-Directed Drug To Interrogate an Antiviral Mechanism. Journal of the American Chemical Society. PMID 30375863 DOI: 10.1021/Jacs.8B07988  0.542
2018 van Rosmalen MGM, Li C, Zlotnick A, Wuite GJL, Roos WH. Effect of dsDNA on the Assembly Pathway and Mechanical Strength of SV40 VP1 Virus-like Particles. Biophysical Journal. PMID 30301514 DOI: 10.1016/J.Bpj.2018.07.044  0.702
2018 Zhao Z, Zlotnick A. Virus Assembly Antagonists from Redesigned Antibodies. Structure (London, England : 1993). 26: 1297-1299. PMID 30282016 DOI: 10.1016/J.Str.2018.09.002  0.817
2018 Ruan L, Hadden JA, Zlotnick A. Assembly properties of Hepatitis B Virus core protein mutants correlate with their resistance to assembly-directed antivirals. Journal of Virology. PMID 30089690 DOI: 10.1128/Jvi.01082-18  0.549
2018 Qazi S, Schlicksup CJ, Rittichier J, VanNieuwenhze MS, Zlotnick A. An Assembly-activating Site in the Hepatitis B Virus Capsid Protein can also Trigger Disassembly. Acs Chemical Biology. PMID 29920071 DOI: 10.1021/Acschembio.8B00283  0.856
2018 Brunk N, Lee LS, Glazier JA, Butske WD, Zlotnick A. Molecular Jenga: The Percolation Phase Transition (Collapse) in Virus Capsids. Physical Biology. PMID 29714713 DOI: 10.1088/1478-3975/Aac194  0.579
2018 Zhou J, Kondylis P, Haywood DG, Harms ZD, Lee LS, Zlotnick A, Jacobson SC. Characterization of Virus Capsids and Their Assembly Intermediates by Multi-Cycle Resistive-Pulse Sensing with Four Pores in Series. Analytical Chemistry. PMID 29708733 DOI: 10.1021/Acs.Analchem.8B00452  0.523
2018 Hadden JA, Perilla JR, Schlicksup CJ, Venkatakrishnan B, Zlotnick A, Schulten K. All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits. Elife. 7. PMID 29708495 DOI: 10.7554/Elife.32478  0.821
2018 Lutomski CA, Lyktey NA, Pierson EE, Zhao Z, Zlotnick A, Jarrold MF. Multiple Pathways in Capsid Assembly. Journal of the American Chemical Society. PMID 29672035 DOI: 10.1021/Jacs.8B01804  0.839
2018 Nair S, Zlotnick A. Asymmetric modification of HBV genomes by an endogenous cytidine deaminase inside HBV cores informs a model of reverse transcription. Journal of Virology. PMID 29491156 DOI: 10.1128/Jvi.02190-17  0.479
2018 Schlicksup CJ, Wang JC, Francis S, Venkatakrishnan B, Turner WW, VanNieuwenhze M, Zlotnick A. Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids. Elife. 7. PMID 29377794 DOI: 10.7554/Elife.31473  0.872
2018 Wang JC, Mukhopadhyay S, Zlotnick A. Geometric Defects and Icosahedral Viruses. Viruses. 10. PMID 29300359 DOI: 10.3390/V10010025  0.721
2018 Hadden JA, Perilla JR, Schlicksup CJ, Venkatakrishnan B, Zlotnick A, Schulten K. Author response: All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits Elife. DOI: 10.7554/Elife.32478.028  0.785
2017 Lutomski CA, Lyktey NA, Zhao Z, Pierson EE, Zlotnick A, Jarrold MF. Hepatitis B Virus Capsid Completion Occurs through Error Correction. Journal of the American Chemical Society. PMID 29125756 DOI: 10.1021/Jacs.7B09932  0.844
2017 Rayaprolu V, Moore A, Wang JC, Goh BC, Perilla J, Zlotnick A, Mukhopadhyay S. Length of encapsidated cargo impacts stability and structure of in vitro assembled Alphavirus core-like particles. Journal of Physics. Condensed Matter : An Institute of Physics Journal. PMID 28975896 DOI: 10.1088/1361-648X/Aa90D0  0.728
2017 Lee LS, Brunk N, Haywood DG, Keifer D, Pierson E, Kondylis P, Wang JC, Jacobson SC, Jarrold MF, Zlotnick A. A Molecular Breadboard: Removal and Replacement of Subunits in an Hepatitis B Virus Capsid. Protein Science : a Publication of the Protein Society. PMID 28795465 DOI: 10.1002/Pro.3265  0.68
2017 Patel N, White SJ, Thompson RF, Bingham R, Weiß EU, Maskell DP, Zlotnick A, Dykeman EC, Tuma R, Twarock R, Ranson NA, Stockley PG. HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly. Nature Microbiology. 2: 17098. PMID 28628133 DOI: 10.1038/Nmicrobiol.2017.98  0.518
2017 Li C, Kneller AR, Jacobson SC, Zlotnick A. Single particle observation of SV40 VP1 polyanion-induced assembly shows that substrate size and structure modulate capsid geometry. Acs Chemical Biology. PMID 28323402 DOI: 10.1021/Acschembio.6B01066  0.703
2017 Kondylis P, Zhou J, Harms ZD, Kneller AR, Lee LS, Zlotnick A, Jacobson SC. Nanofluidic Devices with 8 Pores in Series for Real-Time, Resistive-Pulse Analysis of Hepatitis B Virus Capsid Assembly. Analytical Chemistry. PMID 28322548 DOI: 10.1021/Acs.Analchem.6B04491  0.374
2017 Lomonosova E, Zlotnick A, Tavis JE. Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors. Antimicrobial Agents and Chemotherapy. 61. PMID 27956427 DOI: 10.1128/Aac.02441-16  0.425
2016 Zlotnick A, Huiskonen JT. Editorial overview: Virus structure and assembly: Virions - from structure and physics to design principles. Current Opinion in Virology. 18: vii-viii. PMID 27521688 DOI: 10.1016/J.Coviro.2016.07.001  0.474
2016 Chen C, Wang JC, Pierson EE, Keifer DZ, Delaleau M, Gallucci L, Cazenave C, Kann M, Jarrold MF, Zlotnick A. Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes. Plos Pathogens. 12: e1005802. PMID 27518410 DOI: 10.1371/Journal.Ppat.1005802  0.663
2016 Venkatakrishnan B, Zlotnick A. The Structural Biology of Hepatitis B Virus: Form and Function. Annual Review of Virology. 3: 429-451. PMID 27482896 DOI: 10.1146/Annurev-Virology-110615-042238  0.847
2016 Hoover HS, Wang JC, Middleton S, Ni P, Zlotnick A, Vaughan RC, Kao CC. Phosphorylation of the Brome Mosaic Virus Capsid Regulates the Timing of Viral Infection. Journal of Virology. 90: 7748-60. PMID 27334588 DOI: 10.1128/Jvi.00833-16  0.506
2016 Venkatakrishnan B, Katen SP, Francis S, Chirapu S, Finn MG, Zlotnick A. Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. Journal of Virology. 90: 3994-4004. PMID 26842475 DOI: 10.1128/Jvi.03058-15  0.865
2016 Pierson EE, Keifer DZ, Kukreja AA, Wang JC, Zlotnick A, Jarrold MF. Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids. Journal of Molecular Biology. 428: 292-300. PMID 26151485 DOI: 10.1016/J.Jmb.2015.06.019  0.622
2016 Harms ZD, Lee LS, Zlotnick A, Jacobson SC. FIB-Milled Nanopore Sensors for Tracking Virus Assembly Microscopy and Microanalysis. 22: 150-151. DOI: 10.1017/S1431927616001604  0.423
2016 Li P, Connelly E, Zong Y, Zhou Y, Sun S, Zlotnick A, Arnold L, Lopatin U, Huang Q. Complete Blockage of HBV Virus Replication and Inhibition of cccDNA Formation by Core Protein Allosteric Modifiers Journal of Hepatology. 64: S598. DOI: 10.1016/S0168-8278(16)01104-1  0.57
2016 Huang Q, Mercier A, Zhou Y, Henne K, Kumar GR, Sun S, Guo L, Liu J, Zong Y, Sun T, Nabel K, Li P, Mahon C, Chen G, Bures M, ... ... Zlotnick A, et al. Preclinical Characterization of Potent Core Protein Assembly Modulators for the Treatment of Chronic Hepatitis B Journal of Hepatology. 64: S584. DOI: 10.1016/S0168-8278(16)01072-2  0.823
2015 Selzer L, Zlotnick A. Assembly and Release of Hepatitis B Virus. Cold Spring Harbor Perspectives in Medicine. 5. PMID 26552701 DOI: 10.1101/Cshperspect.A021394  0.856
2015 Selzer L, Kant R, Wang JC, Bothner B, Zlotnick A. Hepatitis B Virus Core Protein Phosphorylation Sites Affect Capsid Stability and Transient Exposure of the C-terminal Domain. The Journal of Biological Chemistry. 290: 28584-93. PMID 26405031 DOI: 10.1074/Jbc.M115.678441  0.859
2015 Wang JC, Chen C, Rayaprolu V, Mukhopadhyay S, Zlotnick A. Self-Assembly of an Alphavirus Core-like Particle Is Distinguished by Strong Intersubunit Association Energy and Structural Defects. Acs Nano. 9: 8898-906. PMID 26275088 DOI: 10.1021/Acsnano.5B02632  0.746
2015 Harms ZD, Selzer L, Zlotnick A, Jacobson SC. Monitoring Assembly of Virus Capsids with Nanofluidic Devices. Acs Nano. 9: 9087-96. PMID 26266555 DOI: 10.1021/Acsnano.5B03231  0.819
2015 Zlotnick A, Venkatakrishnan B, Tan Z, Lewellyn E, Turner W, Francis S. Core protein: A pleiotropic keystone in the HBV lifecycle. Antiviral Research. 121: 82-93. PMID 26129969 DOI: 10.1016/J.Antiviral.2015.06.020  0.874
2015 Singharoy A, Venkatakrishnan B, Liu Y, Mayne CG, Lee S, Chen CH, Zlotnick A, Schulten K, Flood AH. Macromolecular Crystallography for Synthetic Abiological Molecules: Combining xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles. Journal of the American Chemical Society. 137: 8810-8. PMID 26121416 DOI: 10.1021/Jacs.5B04407  0.766
2015 Tan Z, Pionek K, Unchwaniwala N, Maguire ML, Loeb DD, Zlotnick A. The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription. Journal of Virology. 89: 3275-84. PMID 25568211 DOI: 10.1128/Jvi.03545-14  0.73
2015 Harms ZD, Haywood DG, Kneller AR, Selzer L, Zlotnick A, Jacobson SC. Single-particle electrophoresis in nanochannels. Analytical Chemistry. 87: 699-705. PMID 25489919 DOI: 10.1021/Ac503527D  0.773
2015 Belloni L, Palumbo G, Lupacchini L, Li L, Reddy Chirapu S, Calvo L, Finn M, Lopatin U, Zlotnick A, Levrero M. P0529 : Anti capsid drugs HAP12 and AT130 target HBV core protein nuclear functions Journal of Hepatology. 62: S513-S514. DOI: 10.1016/S0168-8278(15)30737-6  0.363
2015 Belloni L, Palumbo G, Li L, Chirapu S, Calvo L, Lupacchini L, Finn M, Lopatin U, Zlotnick A, Levrero M. Anti capsid drugs HAP12 and AT130 target HBV core protein nuclear functions Digestive and Liver Disease. 47: e10. DOI: 10.1016/J.Dld.2015.01.026  0.379
2015 van Rosmalen MG, Biebricher AS, Kamsma D, Zlotnick A, Wuite GJ, Roos WH. DNA-Induced Viral Assembly Studied in Real-Time by Optical Tweezers, Acoustic Force Spectroscopy and Atomic Force Microscopy Biophysical Journal. 108: 170a. DOI: 10.1016/J.Bpj.2014.11.940  0.498
2015 Zlotnick A, Venkatakrishnan B, Tan Z, Lewellyn E, Turner W, Francis S. Core protein: A pleiotropic keystone in the HBV lifecycle Antiviral Research. 121: 82-93. DOI: 10.1016/j.antiviral.2015.06.020  0.828
2014 Kukreja AA, Wang JC, Pierson E, Keifer DZ, Selzer L, Tan Z, Dragnea B, Jarrold MF, Zlotnick A. Structurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly. Journal of Virology. 88: 14105-15. PMID 25253350 DOI: 10.1128/Jvi.01840-14  0.854
2014 Selzer L, Katen SP, Zlotnick A. The hepatitis B virus core protein intradimer interface modulates capsid assembly and stability. Biochemistry. 53: 5496-504. PMID 25102363 DOI: 10.1021/Bi500732B  0.873
2014 Wang JC, Zlotnick A, Mecinović J. Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase. Chemical Communications (Cambridge, England). 50: 10281-3. PMID 25056142 DOI: 10.1039/C4Cc04650A  0.489
2014 Wang JC, Nickens DG, Lentz TB, Loeb DD, Zlotnick A. Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice. Proceedings of the National Academy of Sciences of the United States of America. 111: 11329-34. PMID 25034253 DOI: 10.1073/Pnas.1321424111  0.618
2014 Pierson EE, Keifer DZ, Selzer L, Lee LS, Contino NC, Wang JC, Zlotnick A, Jarrold MF. Detection of late intermediates in virus capsid assembly by charge detection mass spectrometry. Journal of the American Chemical Society. 136: 3536-41. PMID 24548133 DOI: 10.1021/Ja411460W  0.864
2014 Belloni L, Li L, Palumbo G, Chirapu S, Calvo L, Finn M, Lopatin U, Zlotnick A, Levrero M. HAPs hepatitis B virus (HBV) capsid inhibitors prevent HBc interaction with the viral minichromosome and selected host cell genes to inhibits transcription and affect cccDNA stability Digestive and Liver Disease. 46: e9. DOI: 10.1016/J.Dld.2014.01.024  0.479
2014 Selzer L, Katen S, Zlotnick A. A Disulfide in HBV Core Protein Dimer Allosterically Modifies Capsid Assembly and Stability Biophysical Journal. 106: 60a. DOI: 10.1016/J.Bpj.2013.11.413  0.853
2014 Tan Z, Unchwaniwala N, Pionek K, Maguire M, Loeb D, Zlotnick A. Protein Interactions Regulate Virus Assembly and Replication Biophysical Journal. 106: 60a. DOI: 10.1016/J.Bpj.2013.11.412  0.762
2013 Kler S, Wang JC, Dhason M, Oppenheim A, Zlotnick A. Scaffold properties are a key determinant of the size and shape of self-assembled virus-derived particles. Acs Chemical Biology. 8: 2753-61. PMID 24093474 DOI: 10.1021/Cb4005518  0.615
2013 He L, Porterfield Z, van der Schoot P, Zlotnick A, Dragnea B. Hepatitis virus capsid polymorph stability depends on encapsulated cargo size. Acs Nano. 7: 8447-54. PMID 24010404 DOI: 10.1021/Nn4017839  0.583
2013 Katen SP, Tan Z, Chirapu SR, Finn MG, Zlotnick A. Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure. Structure (London, England : 1993). 21: 1406-16. PMID 23871485 DOI: 10.1016/J.Str.2013.06.013  0.87
2013 Zlotnick A, Porterfield JZ, Wang JC. To build a virus on a nucleic acid substrate. Biophysical Journal. 104: 1595-604. PMID 23561536 DOI: 10.1016/J.Bpj.2013.02.005  0.855
2013 Zlotnick A, Tan Z, Selzer L. One protein, at least three structures, and many functions. Structure (London, England : 1993). 21: 6-8. PMID 23312031 DOI: 10.1016/J.Str.2012.12.003  0.829
2013 Tan Z, Maguire ML, Loeb DD, Zlotnick A. Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture. Journal of Virology. 87: 3208-16. PMID 23283960 DOI: 10.1128/Jvi.03014-12  0.759
2013 Li L, Chirapu SR, Finn MG, Zlotnick A. Phase diagrams map the properties of antiviral agents directed against hepatitis B virus core assembly. Antimicrobial Agents and Chemotherapy. 57: 1505-8. PMID 23208717 DOI: 10.1128/Aac.01766-12  0.64
2013 Harms Z, Haywood D, Selzer L, Kneller A, Zlotnick A, Jacobson S. Multi-Pore Sensing of Virus Capsids in In-Plane Nanofluidic Devices Microscopy and Microanalysis. 19: 890-891. DOI: 10.1017/S1431927613006442  0.375
2013 Belloni L, Li L, Palumbo G, Chirapu S, Calvo L, Finn M, Zlotnick A, Levrero M. T-18 The HBV capsid inhibitors HAPs affect core protein interaction with the minichromosome and target cccDNA function Digestive and Liver Disease. 45: S19. DOI: 10.1016/S1590-8658(13)60054-7  0.396
2013 Bassit L, Ozturk T, Tao S, Boucle S, Ehteshami M, Zlotnick A, Feitelson M, Schinazi R. 736 NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES Journal of Hepatology. 58: S298-S299. DOI: 10.1016/S0168-8278(13)60738-2  0.347
2013 Belloni L, Li L, Palumbo G, Chirapu S, Calvo L, Finn M, Zlotnick A, Levrero M. 371 HAPS HEPATITIS B VIRUS (HBV) CAPSID INHIBITORS AFFECT CORE PROTEIN INTERACTION WITH THE MINICHROMOSOME AND TARGET cccDNA FUNCTION Journal of Hepatology. 58: S153. DOI: 10.1016/S0168-8278(13)60373-6  0.528
2013 Katen SP, Tan Z, Chirapu SR, Finn MG, Zlotnick A. Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure Structure. 21: 1406-1416. DOI: 10.1016/j.str.2013.06.013  0.859
2012 van Eldijk MB, Wang JC, Minten IJ, Li C, Zlotnick A, Nolte RJ, Cornelissen JJ, van Hest JC. Designing two self-assembly mechanisms into one viral capsid protein. Journal of the American Chemical Society. 134: 18506-9. PMID 23101937 DOI: 10.1021/Ja308132Z  0.801
2012 Wang JC, Dhason MS, Zlotnick A. Structural organization of pregenomic RNA and the carboxy-terminal domain of the capsid protein of hepatitis B virus. Plos Pathogens. 8: e1002919. PMID 23028319 DOI: 10.1371/Journal.Ppat.1002919  0.634
2012 Li C, Wang JC, Taylor MW, Zlotnick A. In vitro assembly of an empty picornavirus capsid follows a dodecahedral path. Journal of Virology. 86: 13062-9. PMID 23015694 DOI: 10.1128/Jvi.01033-12  0.716
2012 Dhason MS, Wang JC, Hagan MF, Zlotnick A. Differential assembly of Hepatitis B Virus core protein on single- and double-stranded nucleic acid suggest the dsDNA-filled core is spring-loaded. Virology. 430: 20-9. PMID 22595445 DOI: 10.1016/J.Virol.2012.04.012  0.708
2012 Zlotnick A, Suhanovsky MM, Teschke CM. The energetic contributions of scaffolding and coat proteins to the assembly of bacteriophage procapsids. Virology. 428: 64-9. PMID 22520942 DOI: 10.1016/J.Virol.2012.03.017  0.448
2012 Kler S, Asor R, Li C, Ginsburg A, Harries D, Oppenheim A, Zlotnick A, Raviv U. RNA encapsidation by SV40-derived nanoparticles follows a rapid two-state mechanism. Journal of the American Chemical Society. 134: 8823-30. PMID 22329660 DOI: 10.1021/Ja2110703  0.711
2012 Raviv U, Asor R, Kler S, Li C, Ginsburg A, Harries D, Oppenheim A, Zlotnick A. High Resolution Time-Resolved SAXS shows that RNA-Induced SV40 Capsid Protein Self-Assembly is very Fast and without Detectable Concentrations of Intermediates Biophysical Journal. 102: 643a. DOI: 10.1016/J.Bpj.2011.11.3501  0.722
2011 Chen C, Wang JC, Zlotnick A. A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro. Plos Pathogens. 7: e1002388. PMID 22114561 DOI: 10.1371/Journal.Ppat.1002388  0.711
2011 Harms ZD, Mogensen KB, Nunes PS, Zhou K, Hildenbrand BW, Mitra I, Tan Z, Zlotnick A, Kutter JP, Jacobson SC. Nanofluidic devices with two pores in series for resistive-pulse sensing of single virus capsids. Analytical Chemistry. 83: 9573-8. PMID 22029283 DOI: 10.1021/Ac202358T  0.593
2011 Lai Y, Yi G, Chen A, Bhardwaj K, Tragesser BJ, Rodrigo A Valverde, Zlotnick A, Mukhopadhyay S, Ranjith-Kumar CT, Kao CC. Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. Plos One. 6: e25837. PMID 22016778 DOI: 10.1371/Journal.Pone.0025837  0.6
2011 Zhou K, Li L, Tan Z, Zlotnick A, Jacobson SC. Characterization of hepatitis B virus capsids by resistive-pulse sensing. Journal of the American Chemical Society. 133: 1618-21. PMID 21265511 DOI: 10.1021/Ja108228X  0.697
2011 Zlotnick A, Mukhopadhyay S. Virus assembly, allostery and antivirals. Trends in Microbiology. 19: 14-23. PMID 21163649 DOI: 10.1016/J.Tim.2010.11.003  0.762
2010 Porterfield JZ, Zlotnick A. A simple and general method for determining the protein and nucleic acid content of viruses by UV absorbance. Virology. 407: 281-8. PMID 20850162 DOI: 10.1016/J.Virol.2010.08.015  0.81
2010 Katen SP, Chirapu SR, Finn MG, Zlotnick A. Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators. Acs Chemical Biology. 5: 1125-36. PMID 20845949 DOI: 10.1021/Cb100275B  0.875
2010 Moisant P, Neeman H, Zlotnick A. Exploring the paths of (virus) assembly. Biophysical Journal. 99: 1350-7. PMID 20816046 DOI: 10.1016/J.Bpj.2010.06.030  0.483
2010 Porterfield JZ, Dhason MS, Loeb DD, Nassal M, Stray SJ, Zlotnick A. Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity. Journal of Virology. 84: 7174-84. PMID 20427522 DOI: 10.1128/Jvi.00586-10  0.84
2010 Burns K, Mukherjee S, Keef T, Johnson JM, Zlotnick A. Altering the energy landscape of virus self-assembly to generate kinetically trapped nanoparticles. Biomacromolecules. 11: 439-42. PMID 20136150 DOI: 10.1021/Bm901160B  0.693
2010 Mukherjee S, Kler S, Oppenheim A, Zlotnick A. Uncatalyzed assembly of spherical particles from SV40 VP1 pentamers and linear dsDNA incorporates both low and high cooperativity elements. Virology. 397: 199-204. PMID 19942248 DOI: 10.1016/J.Virol.2009.10.050  0.357
2010 Packianathan C, Katen SP, Dann CE, Zlotnick A. Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly. Journal of Virology. 84: 1607-15. PMID 19939922 DOI: 10.1128/Jvi.02033-09  0.877
2009 Katen S, Zlotnick A. The thermodynamics of virus capsid assembly. Methods in Enzymology. 455: 395-417. PMID 19289214 DOI: 10.1016/S0076-6879(08)04214-6  0.856
2009 Bourne CR, Katen SP, Fulz MR, Packianathan C, Zlotnick A. A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly. Biochemistry. 48: 1736-42. PMID 19196007 DOI: 10.1021/Bi801814Y  0.869
2008 Bourne C, Lee S, Venkataiah B, Lee A, Korba B, Finn MG, Zlotnick A. Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle. Journal of Virology. 82: 10262-70. PMID 18684823 DOI: 10.1128/Jvi.01360-08  0.831
2008 Mukherjee S, Thorsteinsson MV, Johnston LB, DePhillips PA, Zlotnick A. A quantitative description of in vitro assembly of human papillomavirus 16 virus-like particles. Journal of Molecular Biology. 381: 229-37. PMID 18585738 DOI: 10.1016/J.Jmb.2008.05.079  0.392
2008 Hilmer JK, Zlotnick A, Bothner B. Conformational equilibria and rates of localized motion within hepatitis B virus capsids. Journal of Molecular Biology. 375: 581-94. PMID 18022640 DOI: 10.1016/J.Jmb.2007.10.044  0.609
2007 Zlotnick A, Lee A, Bourne CR, Johnson JM, Domanico PL, Stray SJ. In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions). Nature Protocols. 2: 490-8. PMID 17406612 DOI: 10.1038/Nprot.2007.60  0.858
2007 Zlotnick A. Distinguishing reversible from irreversible virus capsid assembly. Journal of Molecular Biology. 366: 14-8. PMID 17157314 DOI: 10.1016/J.Jmb.2006.11.034  0.404
2006 Stray SJ, Zlotnick A. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. Journal of Molecular Recognition : Jmr. 19: 542-8. PMID 17006877 DOI: 10.1002/Jmr.801  0.853
2006 Bourne CR, Finn MG, Zlotnick A. Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1. Journal of Virology. 80: 11055-61. PMID 16943288 DOI: 10.1128/Jvi.00933-06  0.816
2006 Parent KN, Zlotnick A, Teschke CM. Quantitative analysis of multi-component spherical virus assembly: scaffolding protein contributes to the global stability of phage P22 procapsids. Journal of Molecular Biology. 359: 1097-106. PMID 16697406 DOI: 10.1016/J.Jmb.2006.03.068  0.546
2006 Tang J, Johnson JM, Dryden KA, Young MJ, Zlotnick A, Johnson JE. The role of subunit hinges and molecular "switches" in the control of viral capsid polymorphism. Journal of Structural Biology. 154: 59-67. PMID 16495083 DOI: 10.1016/J.Jsb.2005.10.013  0.619
2006 Mukherjee S, Pfeifer CM, Johnson JM, Liu J, Zlotnick A. Redirecting the coat protein of a spherical virus to assemble into tubular nanostructures. Journal of the American Chemical Society. 128: 2538-9. PMID 16492029 DOI: 10.1021/Ja056656F  0.582
2006 Stray SJ, Johnson JM, Kopek BG, Zlotnick A. An in vitro fluorescence screen to identify antivirals that disrupt hepatitis B virus capsid assembly. Nature Biotechnology. 24: 358-62. PMID 16474383 DOI: 10.1038/Nbt1187  0.823
2005 Zlotnick A. Theoretical aspects of virus capsid assembly. Journal of Molecular Recognition : Jmr. 18: 479-90. PMID 16193532 DOI: 10.1002/Jmr.754  0.587
2005 Endres D, Miyahara M, Moisant P, Zlotnick A. A reaction landscape identifies the intermediates critical for self-assembly of virus capsids and other polyhedral structures. Protein Science : a Publication of the Protein Society. 14: 1518-25. PMID 15930000 DOI: 10.1110/Ps.041314405  0.504
2005 Stray SJ, Bourne CR, Punna S, Lewis WG, Finn MG, Zlotnick A. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proceedings of the National Academy of Sciences of the United States of America. 102: 8138-43. PMID 15928089 DOI: 10.1073/Pnas.0409732102  0.871
2005 Johnson JM, Tang J, Nyame Y, Willits D, Young MJ, Zlotnick A. Regulating self-assembly of spherical oligomers. Nano Letters. 5: 765-70. PMID 15826125 DOI: 10.1021/Nl050274Q  0.49
2005 Bourne C, Zlotnick A. Structural study of hepatitis B virus capsid polymorphism and stabilization Acta Crystallographica Section a Foundations of Crystallography. 61: c237-c237. DOI: 10.1107/S0108767305089919  0.403
2005 Zlotnick A. Simple models and simple analyses of virus capsid assembly Journal of Theoretical Medicine. 6: 111-114. DOI: 10.1080/10273660500149943  0.498
2004 Zlotnick A. Viruses and the physics of soft condensed matter. Proceedings of the National Academy of Sciences of the United States of America. 101: 15549-50. PMID 15505200 DOI: 10.1073/Pnas.0406935101  0.453
2004 Ceres P, Stray SJ, Zlotnick A. Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L. Journal of Virology. 78: 9538-43. PMID 15308745 DOI: 10.1128/Jvi.78.17.9538-9543.2004  0.843
2004 Stray SJ, Ceres P, Zlotnick A. Zinc ions trigger conformational change and oligomerization of hepatitis B virus capsid protein. Biochemistry. 43: 9989-98. PMID 15287726 DOI: 10.1021/Bi049571K  0.852
2004 Johnson JM, Willits DA, Young MJ, Zlotnick A. Interaction with capsid protein alters RNA structure and the pathway for in vitro assembly of cowpea chlorotic mottle virus. Journal of Molecular Biology. 335: 455-64. PMID 14672655 DOI: 10.1016/J.Jmb.2003.10.059  0.456
2003 Zlotnick A, Stray SJ. How does your virus grow? Understanding and interfering with virus assembly. Trends in Biotechnology. 21: 536-42. PMID 14624862 DOI: 10.1016/J.Tibtech.2003.09.012  0.826
2003 Zlotnick A. Are weak protein-protein interactions the general rule in capsid assembly? Virology. 315: 269-74. PMID 14585329 DOI: 10.1016/S0042-6822(03)00586-5  0.427
2003 Willits D, Zhao X, Olson N, Baker TS, Zlotnick A, Johnson JE, Douglas T, Young MJ. Effects of the cowpea chlorotic mottle bromovirus beta-hexamer structure on virion assembly. Virology. 306: 280-8. PMID 12642101 DOI: 10.1016/S0042-6822(02)00054-5  0.542
2003 Singh S, Zlotnick A. Observed hysteresis of virus capsid disassembly is implicit in kinetic models of assembly. The Journal of Biological Chemistry. 278: 18249-55. PMID 12639968 DOI: 10.1074/Jbc.M211408200  0.629
2002 Gulati U, Hwang CC, Venkatramani L, Gulati S, Stray SJ, Lee JT, Laver WG, Bochkarev A, Zlotnick A, Air GM. Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98). Journal of Virology. 76: 12274-80. PMID 12414967 DOI: 10.1128/Jvi.76.23.12274-12280.2002  0.79
2002 Ceres P, Zlotnick A. Weak protein-protein interactions are sufficient to drive assembly of hepatitis B virus capsids. Biochemistry. 41: 11525-31. PMID 12269796 DOI: 10.1021/Bi0261645  0.876
2002 Endres D, Zlotnick A. Model-based analysis of assembly kinetics for virus capsids or other spherical polymers. Biophysical Journal. 83: 1217-30. PMID 12124301 DOI: 10.1016/S0006-3495(02)75245-4  0.525
2002 Zlotnick A, Ceres P, Singh S, Johnson JM. A small molecule inhibits and misdirects assembly of hepatitis B virus capsids. Journal of Virology. 76: 4848-54. PMID 11967301 DOI: 10.1128/Jvi.76.10.4848-4854.2002  0.87
2000 Zlotnick A, Aldrich R, Johnson JM, Ceres P, Young MJ. Mechanism of capsid assembly for an icosahedral plant virus Virology. 277: 450-456. PMID 11080492 DOI: 10.1006/Viro.2000.0619  0.867
1999 Zlotnick A, Johnson JM, Wingfield PW, Stahl SJ, Endres D. A theoretical model successfully identifies features of hepatitis B virus capsid assembly Biochemistry. 38: 14644-14652. PMID 10545189 DOI: 10.1021/Bi991611A  0.596
1999 Zlotnick A, Palmer I, Kaufman JD, Stahl SJ, Steven AC, Wingfield PT. Separation and crystallization of T = 3 and T = 4 icosahedral complexes of the hepatitis B virus core protein Acta Crystallographica Section D: Biological Crystallography. 55: 717-720. PMID 10089479 DOI: 10.1107/S090744499801350X  0.609
1998 Conway JF, Cheng N, Zlotnick A, Stahl SJ, Wingfield PT, Steven AC. Localization of the N terminus of hepatitis B virus capsid protein by peptide-based difference mapping from cryoelectron microscopy Proceedings of the National Academy of Sciences of the United States of America. 95: 14622-14627. PMID 9843939 DOI: 10.1073/Pnas.95.25.14622  0.622
1998 Zlotnick A, Stahl SJ, Wingfield PT, Conway JF, Cheng N, Steven AC. Shared motifs of the capsid proteins of hepadnaviruses and retroviruses suggest a common evolutionary origin Febs Letters. 431: 301-304. PMID 9714530 DOI: 10.1016/S0014-5793(98)00755-8  0.629
1998 Conway JF, Cheng N, Zlotnick A, Stahl SJ, Wingfield PT, Belnap DM, Kanngiesser U, Noah M, Steven AC. Hepatitis B virus capsid: Localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens Journal of Molecular Biology. 279: 1111-1121. PMID 9642088 DOI: 10.1006/Jmbi.1998.1845  0.662
1998 Conway J, Cheng N, Zlotnick A, Stahl S, Wingfield P, Belnap D, Steven A. High Resolution Epitope Mapping of the Hepatitis B Virus Capsid by Cryo-Electron Microscopy Microscopy and Microanalysis. 4: 966-967. DOI: 10.1017/S1431927600024958  0.438
1997 Zlotnick A, Cheng N, Stahl SJ, Conway JF, Steven AC, Wingfield PT. Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: Implications for morphogenesis and organization of encapsidated RNA Proceedings of the National Academy of Sciences of the United States of America. 94: 9556-9561. PMID 9275161 DOI: 10.1073/Pnas.94.18.9556  0.639
1997 Steven AC, Trus BL, Booy FP, Cheng N, Zlotnick A, Caston JR, Conway JF. The making and breaking of symmetry in virus capsid assembly: Glimpses of capsid biology from cryoelectron microscopy Faseb Journal. 11: 733-742. PMID 9271358 DOI: 10.1096/Fasebj.11.10.9271358  0.706
1997 Wingfield PT, Stahl SJ, Kaufman J, Zlotnick A, Hyde CC, Gronenborn AM, Clore GM. The extracellular domain of immunodeficiency virus gp41 protein: Expression in Escherichia coli, purification, and crystallization Protein Science. 6: 1653-1660. PMID 9260278 DOI: 10.1002/Pro.5560060806  0.38
1997 Conway JF, Cheng N, Zlotnick A, Wingfield PT, Stahl SJ, Steven AC. Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy Nature. 386: 91-94. PMID 9052787 DOI: 10.1038/386091A0  0.653
1997 Conway JF, Cheng N, Zlotnick A, Wingfield PT, Stahl SJ, Steven AC. Computational Methods for High Resolution Analysis of Cryo-Electron Micrographs of Hepatitis B Virus Capsids Microscopy and Microanalysis. 3: 1115-1116. DOI: 10.1017/S1431927600012460  0.608
1996 Zlotnick A, Cheng N, Conway JF, Booy FP, Steven AC, Stahl SJ, Wingfield PT. Dimorphism of hepatitis B virus capsids is strongly influenced by the C-terminus of the capsid protein Biochemistry. 35: 7412-7421. PMID 8652518 DOI: 10.1021/bi9604800  0.645
1995 Muckelbauer JK, Kremer M, Minor I, Tong L, Zlotnick A, Johnson JE, Rossmann MG. Structure determination of coxsackievirus B3 to 3.5 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 51: 871-87. PMID 15299757 DOI: 10.1107/S0907444995002253  0.606
1994 Zlotnick A. To build a virus capsid: An equilibrium model of the self assembly of polyhedral protein complexes Journal of Molecular Biology. 241: 59-67. PMID 8051707 DOI: 10.1006/Jmbi.1994.1473  0.62
1993 Zlotnick A, McKinney BR, Munshi S, Bibler J, Rossmann MG, Johnson JE. A monoclinic crystal with R32 pseudo-symmetry: a preliminary report of Nodamura virus structure determination. Acta Crystallographica. Section D, Biological Crystallography. 49: 580-7. PMID 15299495 DOI: 10.1107/S0907444993007498  0.656
1991 MacFarlane SA, Shanks M, Davies JW, Zlotnick A, Lomonossoff GP. Analysis of the nucleotide sequence of bean pod mottle virus middle component RNA Virology. 183: 405-409. PMID 2053290 DOI: 10.1016/0042-6822(91)90155-5  0.331
1990 Brenner SL, Zlotnick A, Stafford WF. RecA Protein self-assembly. II. Analytical equilibrium ultracentrifugation studies of the entropy-driven self-association of RecA Journal of Molecular Biology. 216: 949-964. PMID 2266565 DOI: 10.1016/S0022-2836(99)80013-8  0.376
1988 Brenner SL, Zlotnick A, Griffith JD. RecA protein self-assembly multiple discrete aggregation states Journal of Molecular Biology. 204: 959-972. PMID 3065521 DOI: 10.1016/0022-2836(88)90055-1  0.441
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