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Milton Brown - Publications

Affiliations: 
2004 Chemistry University of Virginia, Charlottesville, VA 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Das A, Merrill P, Wilson J, Turner T, Paige M, Capitosti S, Brown M, Freshcorn B, Sok MCP, Song H, Botchwey EA. Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches. Regenerative Engineering and Translational Medicine. 5: 30-41. PMID 31008183 DOI: 10.1007/s40883-018-0077-8  0.772
2017 Nathan S, Ma Y, Tomita YA, De Oliveira E, Brown ML, Rosen EM. BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells. Breast Cancer Research and Treatment. PMID 28808806 DOI: 10.1007/S10549-017-4442-Y  0.797
2016 Cordova A, Woodrick J, Grindrod S, Zhang L, Saygideger-Kont Y, Wang K, DeVito S, Daniele S, Paige M, Brown ML. Aminopeptidase P mediated targeting for breast tissue specific conjugate delivery. Bioconjugate Chemistry. PMID 26965452 DOI: 10.1021/Acs.Bioconjchem.5B00481  0.702
2015 Ma Y, Preet A, Tomita Y, De Oliveira E, Zhang L, Ueda Y, Clarke R, Brown M, Rosen EM. A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance. Oncotarget. PMID 26575173 DOI: 10.18632/Oncotarget.6323  0.793
2014 Ma Y, Tomita Y, Preet A, Clarke R, Englund E, Grindrod S, Nathan S, De Oliveira E, Brown ML, Rosen EM. Small-molecule "BRCA1-mimetics" are antagonists of estrogen receptor-α. Molecular Endocrinology (Baltimore, Md.). 28: 1971-86. PMID 25264941 DOI: 10.1210/Me.2014-1146  0.752
2014 Hou S, Yi YW, Kang HJ, Zhang L, Kim HJ, Kong Y, Liu Y, Wang K, Kong HS, Grindrod S, Bae I, Brown ML. Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6. Journal of Medicinal Chemistry. 57: 6342-53. PMID 24978112 DOI: 10.1021/Jm4018042  0.739
2012 Suy S, Hansen TP, Auto HD, Kallakury BV, Dailey V, Danner M, Macarthur L, Zhang Y, Miessau MJ, Collins SP, Brown ML. Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade. Journal of Clinical & Experimental Oncology. 1. PMID 24163825 DOI: 10.4172/2324-9110.1000102  0.629
2012 Walls TH, Grindrod SC, Beraud D, Zhang L, Baheti AR, Dakshanamurthy S, Patel MK, Brown ML, MacArthur LH. Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent. Bioorganic & Medicinal Chemistry. 20: 5269-76. PMID 22863530 DOI: 10.1016/J.Bmc.2012.06.042  0.763
2012 Davis GC, Kong Y, Paige M, Li Z, Merrick EC, Hansen T, Suy S, Wang K, Dakshanamurthy S, Cordova A, McManus OB, Williams BS, Chruszcz M, Minor W, Patel MK, ... Brown ML, et al. Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts. Bioorganic & Medicinal Chemistry. 20: 2180-8. PMID 22364743 DOI: 10.1016/J.Bmc.2011.08.061  0.678
2012 Sirajuddin P, Das S, Ringer L, Salinas P, Rodriguez O, Moasser B, Yenugonda VM, Albanese C, Brown M. Abstract 4774: LC-MS/MS detection of the dansyl-modified biologically active CDK inhibitor VMY-1-103 using an in vivo model system Cancer Research. 72: 4774-4774. DOI: 10.1158/1538-7445.Am2012-4774  0.335
2012 Kosturko GW, Bulut G, Hong S, Rodriguez V, Brown M, Toretsky J, Khanna C, Paige M, Uren A. Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma Cancer Research. 72: 3906-3906. DOI: 10.1158/1538-7445.Am2012-3906  0.371
2011 Grindrod S, Suy S, Fallen S, Eto M, Toretsky J, Brown ML. Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cells. Frontiers in Oncology. 1: 27. PMID 22655237 DOI: 10.3389/Fonc.2011.00027  0.74
2011 Kong Y, Jung M, Wang K, Grindrod S, Velena A, Lee SA, Dakshanamurthy S, Yang Y, Miessau M, Zheng C, Dritschilo A, Brown ML. Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor. Molecular Cancer Therapeutics. 10: 1591-9. PMID 21697394 DOI: 10.1158/1535-7163.Mct-10-0779  0.724
2011 De Oliveira EO, Graf KM, Patel MK, Baheti A, Kong HS, MacArthur LH, Dakshanamurthy S, Wang K, Brown ML, Paige M. Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers. Bioorganic & Medicinal Chemistry. 19: 4322-9. PMID 21683602 DOI: 10.1016/J.Bmc.2011.05.043  0.774
2011 Yenugonda VM, Deb TB, Grindrod SC, Dakshanamurthy S, Yang Y, Paige M, Brown ML. Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells. Bioorganic & Medicinal Chemistry. 19: 2714-25. PMID 21440449 DOI: 10.1016/J.Bmc.2011.02.052  0.74
2010 Ringer L, Sirajuddin P, Yenugonda VM, Ghosh A, Divito K, Trabosh V, Patel Y, Brophy A, Grindrod S, Lisanti MP, Rosenthal D, Brown ML, Avantaggiati ML, Rodriguez O, Albanese C. VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer Biology & Therapy. 10: 320-5. PMID 20574155 DOI: 10.4161/Cbt.10.4.12208  0.733
2010 Sheikh KD, Banerjee PP, Jagadeesh S, Grindrod SC, Zhang L, Paige M, Brown ML. Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft. Journal of Medicinal Chemistry. 53: 2376-82. PMID 20184324 DOI: 10.1021/Jm9011615  0.775
2010 Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & Medicinal Chemistry. 18: 1103-10. PMID 20079654 DOI: 10.1016/J.Bmc.2009.12.056  0.682
2009 Graf KM, Tabor MG, Brown ML, Paige M. Synthesis of (S)-jamaicamide C carboxylic acid. Organic Letters. 11: 5382-5. PMID 19943696 DOI: 10.1021/Ol9021222  0.762
2009 Brown ML, Eidam HA, Paige M, Jones PJ, Patel MK. Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels. Bioorganic & Medicinal Chemistry. 17: 7056-63. PMID 19747831 DOI: 10.1016/J.Bmc.2008.11.069  0.644
2009 Wang Y, Jones PJ, Batts TW, Landry V, Patel MK, Brown ML. Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore. Bioorganic & Medicinal Chemistry. 17: 7064-72. PMID 19346132 DOI: 10.1016/J.Bmc.2008.10.031  0.635
2009 Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK. Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. The Journal of Pharmacology and Experimental Therapeutics. 328: 201-12. PMID 18952887 DOI: 10.1124/Jpet.108.144709  0.579
2008 Chinigo GM, Paige M, Grindrod S, Hamel E, Dakshanamurthy S, Chruszcz M, Minor W, Brown ML. Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. Journal of Medicinal Chemistry. 51: 4620-31. PMID 18610995 DOI: 10.1021/Jm800271C  0.789
2008 Hwang SH, Rait A, Pirollo KF, Zhou Q, Yenugonda VM, Chinigo GM, Brown ML, Chang EH. Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue. Molecular Cancer Therapeutics. 7: 559-68. PMID 18347143 DOI: 10.1158/1535-7163.Mct-07-0548  0.765
2007 Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, ... Brown ML, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chemistry & Biology. 14: 1186-97. PMID 17961830 DOI: 10.1016/J.Chembiol.2007.09.006  0.784
2007 Lenkowski PW, Batts TW, Smith MD, Ko SH, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology. 52: 1044-54. PMID 17174360 DOI: 10.1016/J.Neuropharm.2006.11.001  0.786
2007 Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. The Journal of Pharmacology and Experimental Therapeutics. 320: 828-36. PMID 17090703 DOI: 10.1124/Jpet.106.111542  0.79
2007 Chruszcz M, Chinigo GM, Capitosti SM, Brown ML, Minor W. 2-(Biphenyl-4-yl)-2,3-dihydroquinazolin-4(1H)-one Acta Crystallographica Section E: Structure Reports Online. 63: o891-o893. DOI: 10.1107/S1600536807002103  0.732
2006 Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2. Bioorganic & Medicinal Chemistry. 14: 8366-78. PMID 17035036 DOI: 10.1016/J.Bmc.2006.09.010  0.761
2006 Wieghaus KA, Capitosti SM, Anderson CR, Price RJ, Blackman BR, Brown ML, Botchwey EA. Small molecule inducers of angiogenesis for tissue engineering. Tissue Engineering. 12: 1903-13. PMID 16889520 DOI: 10.1089/Ten.2006.12.1903  0.773
2006 Ko SH, Jochnowitz N, Lenkowski PW, Batts TW, Davis GC, Martin WJ, Brown ML, Patel MK. Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist. Neuropharmacology. 50: 865-73. PMID 16464480 DOI: 10.1016/J.Neuropharm.2005.12.008  0.789
2005 Wieghaus KA, Capitosti SM, Brown ML, Botchwey EA. Novel angiogenic compounds for targeted drug delivery Materials Research Society Symposium Proceedings. 845: 357-361. DOI: 10.1557/Proc-845-Aa5.47  0.774
2005 Bushweller JH, Gorczynski MJ, Grembecka J, Newman M, Corpora T, Zhou Y, Kong Y, Jeon J, Liu PP, Brown ML. Development of Small Molecule Inhibitors of the CBFβ-SMMHC Oncoprotein. Blood. 106: 3359-3359. DOI: 10.1182/Blood.V106.11.3359.3359  0.796
2005 Wieghaus KA, Capitosti SM, Brown ML, Botchwey EA. Small molecule stimulators of angiogenesis for bone tissue engineering Proceedings of the 2005 Summer Bioengineering Conference. 2005: 1182-1183.  0.745
2004 Brennen WN, Cooper CR, Capitosti S, Brown ML, Sikes RA. Thalidomide and analogues: current proposed mechanisms and therapeutic usage. Clinical Prostate Cancer. 3: 54-61. PMID 15279692 DOI: 10.3816/Cgc.2004.N.014  0.775
2004 Lenkowski PW, Ko SH, Anderson JD, Brown ML, Patel MK. Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 21: 635-44. PMID 15066664 DOI: 10.1016/J.Ejps.2004.01.004  0.811
2004 Gorczynski MJ, Leal RM, Mooberry SL, Bushweller JH, Brown ML. Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation. Bioorganic & Medicinal Chemistry. 12: 1029-36. PMID 14980616 DOI: 10.1016/J.Bmc.2003.12.003  0.784
2004 Schenck HA, Lenkowski PW, Choudhury-Mukherjee I, Ko SH, Stables JP, Patel MK, Brown ML. Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorganic & Medicinal Chemistry. 12: 979-93. PMID 14980611 DOI: 10.1016/J.Bmc.2003.12.011  0.78
2004 Capitosti SM, Hansen TP, Brown ML. Thalidomide analogues demonstrate dual inhibition of both angiogenesis and prostate cancer. Bioorganic & Medicinal Chemistry. 12: 327-36. PMID 14723953 DOI: 10.1016/J.Bmc.2003.11.007  0.791
2003 Sikes RA, Walls AM, Brennen WN, Anderson JD, Choudhury-Mukherjee I, Schenck HA, Brown ML. Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clinical Prostate Cancer. 2: 181-7. PMID 15040863 DOI: 10.3816/Cgc.2003.N.028  0.803
2003 Anderson JD, Hansen TP, Lenkowski PW, Walls AM, Choudhury IM, Schenck HA, Friehling M, Höll GM, Patel MK, Sikes RA, Brown ML. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Molecular Cancer Therapeutics. 2: 1149-54. PMID 14617788  0.791
2003 Capitosti SM, Hansen TP, Brown ML. Facile synthesis of an azido-labeled thalidomide analogue. Organic Letters. 5: 2865-7. PMID 12889894 DOI: 10.1021/Ol034906W  0.769
2003 Choudhury-Mukherjee I, Schenck HA, Cechova S, Pajewski TN, Kapur J, Ellena J, Cafiso DS, Brown ML. Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. Journal of Medicinal Chemistry. 46: 2494-501. PMID 12773053 DOI: 10.1021/Jm020546R  0.798
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