Timothy J. Mitchison
|Systems Biology||Harvard Medical School, Boston, MA, United States|
Area:Microtubules, Actin, Mitosis, Cell cycle
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Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.
Cross-listing: Chemistry Tree
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|Gasic I, Mitchison TJ. (2018) Autoregulation and repair in microtubule homeostasis. Current Opinion in Cell Biology. 56: 80-87|
|Jun HJ, Appleman VA, Wu HJ, et al. (2018) A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications. 9: 3116|
|Wang Y, Li YM, Baitsch L, et al. (2018) Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 7|
|Field CM, Mitchison TJ. (2018) Assembly of Spindles and Asters in Xenopus Egg Extracts. Cold Spring Harbor Protocols|
|Mitchison TJ, Field CM. (2017) Spindle-to-Cortex Communication in Cleaving Frog Eggs. Cold Spring Harbor Symposia On Quantitative Biology|
|Zhang L, Hou Y, Li Z, et al. (2017) Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 6|
|Guild J, Ginzberg MB, Hueschen CL, et al. (2017) Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Molecular Biology of the Cell|
|Costigliola N, Ding L, Burckhardt CJ, et al. (2017) Vimentin fibers orient traction stress. Proceedings of the National Academy of Sciences of the United States of America|
|Hanley ML, Yoo TY, Sonnett M, et al. (2017) Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin. Molecular Biology of the Cell|
|Shi J, Mitchison TJ. (2017) Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. Endocrine-Related Cancer|