Timothy J. Mitchison
|Systems Biology||Harvard Medical School, Boston, MA, United States|
Area:Microtubules, Actin, Mitosis, Cell cycle
Google:"Timothy J. Mitchison"
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.
Cross-listing: Chemistry Tree
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|Geisterfer ZM, Zhu DY, Mitchison TJ, et al. (2020) Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density. Current Biology : Cb|
|Gasic I, Groendyke BJ, Nowak RP, et al. (2020) Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells. 9|
|Lin Z, Gasic I, Chandrasekaran V, et al. (2019) TTC5 mediates autoregulation of tubulin via mRNA degradation. Science (New York, N.Y.)|
|Mitchison TJ, Field CM. (2019) Toward synthetic cells. Science (New York, N.Y.). 366: 569-570|
|Field CM, Pelletier JF, Mitchison TJ. (2019) Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs. Current Biology : Cb|
|Florian S, Iwamoto Y, Coughlin M, et al. (2019) A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proceedings of the National Academy of Sciences of the United States of America|
|Gasic I, Boswell SA, Mitchison TJ. (2019) Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues. Plos Biology. 17: e3000225|
|Silva MC, Ferguson FM, Cai Q, et al. (2019) Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 8|
|Song Y, Subramanian K, Berberich MJ, et al. (2019) A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Scientific Data. 6: 190016|
|Nguyen T, Mitchison TJ, Wühr M. (2019) Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos. Methods in Molecular Biology (Clifton, N.J.). 1920: 17-32|