Timothy J. Mitchison
|Systems Biology||Harvard Medical School, Boston, MA, United States|
Area:Microtubules, Actin, Mitosis, Cell cycle
Google:"Timothy J. Mitchison"
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.
Cross-listing: Chemistry Tree
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|Ng TL, Olson EJ, Yoo TY, et al. (2022) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. Msystems. e0146621|
|Yoo TY, Mitchison T. (2021) Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline. Biorxiv : the Preprint Server For Biology|
|Mitchison TJ, Field CM. (2021) Self-Organization of Cellular Units. Annual Review of Cell and Developmental Biology|
|Yoo TY, Mitchison TJ. (2021) O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport. The Journal of Cell Biology. 220|
|Pelletier JF, Field CM, Fuerthauer S, et al. (2020) Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 9|
|Luthria G, Li R, Wang S, et al. (2020) In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nature Communications. 11: 3521|
|Geisterfer ZM, Zhu DY, Mitchison TJ, et al. (2020) Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density. Current Biology : Cb|
|Gasic I, Groendyke BJ, Nowak RP, et al. (2020) Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells. 9|
|Lin Z, Gasic I, Chandrasekaran V, et al. (2019) TTC5 mediates autoregulation of tubulin via mRNA degradation. Science (New York, N.Y.)|
|Mitchison TJ, Field CM. (2019) Toward synthetic cells. Science (New York, N.Y.). 366: 569-570|