Timothy J. Mitchison

Systems Biology Harvard Medical School, Boston, MA, United States 
Microtubules, Actin, Mitosis, Cell cycle
"Timothy J. Mitchison"

Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.

Cross-listing: Chemistry Tree


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Marc W. Kirschner grad student 1984 UCSF
 (Structure and dynamics of organized microtubule arrays)


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Matt Welch grad student UCSF
Julie Theriot grad student 1993 UCSF
Narat J. Eungdamrong grad student 2002 Harvard
Michele Shirasu-Hiza grad student 2003 UCSF
Zoltan Maliga grad student 2004 Harvard
David T. Miyamoto grad student 2004 Harvard
Justin C. Yarrow grad student 2004 Harvard
Zachary E. Perlman grad student 2005 Harvard
Alina M. Vrabioiu grad student 2006 Harvard
Aaron C. Groen grad student 2008 Harvard
Hao Y. Kueh grad student 2008 Harvard
Hsiao-Chun Huang grad student 2010 Harvard
Martin Wühr grad student 2005-2010 Harvard
Chi-Kuo Hu grad student 2011 Harvard
Nefeli E. Georgoulia grad student 2014 Harvard
Arshad Desai post-doc UCSF
Tarun Kapoor post-doc Harvard Medical School
Yuyu Song post-doc Harvard (Neurotree)
Jack Taunton post-doc Harvard Medical School (Chemistry Tree)
Yixian Zheng post-doc UCSF
Ivana Gasic post-doc 2016- Harvard Medical School
Xiang Deng post-doc 2017- Harvard Medical School
Anthony Hyman post-doc 1993 UCSF
Tatsuya Hirano post-doc 1989-1995 UCSF
Claire Ellen Walczak post-doc 1998 UCSF (Chemistry Tree)
R. Scott Lokey post-doc 2002 Harvard Medical School (Chemistry Tree)
Aaron F. Straight post-doc 2004 Harvard Medical School
Paul Chang post-doc 2007 Harvard Medical School (Chemistry Tree)
Daniel J. Needleman post-doc 2005-2008 Harvard (Chemistry Tree)
Ethan C. Garner post-doc 2012 Harvard Medical School
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Gasic I, Boswell SA, Mitchison TJ. (2019) Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues. Plos Biology. 17: e3000225
Silva MC, Ferguson FM, Cai Q, et al. (2019) Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 8
Nguyen T, Mitchison TJ, Wühr M. (2019) Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos. Methods in Molecular Biology (Clifton, N.J.). 1920: 17-32
Gasic I, Mitchison TJ. (2018) Autoregulation and repair in microtubule homeostasis. Current Opinion in Cell Biology. 56: 80-87
Jun HJ, Appleman VA, Wu HJ, et al. (2018) A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications. 9: 3116
Wang Y, Li YM, Baitsch L, et al. (2018) Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 7
Field CM, Mitchison TJ. (2018) Assembly of Spindles and Asters in Xenopus Egg Extracts. Cold Spring Harbor Protocols
Mitchison TJ, Field CM. (2017) Spindle-to-Cortex Communication in Cleaving Frog Eggs. Cold Spring Harbor Symposia On Quantitative Biology
Zhang L, Hou Y, Li Z, et al. (2017) Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 6
Guild J, Ginzberg MB, Hueschen CL, et al. (2017) Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Molecular Biology of the Cell
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