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Timothy J. Mitchison

Affiliations: 
Systems Biology Harvard Medical School, Boston, MA, United States 
Area:
Microtubules, Actin, Mitosis, Cell cycle
Website:
http://www.hms.harvard.edu/dms/bbs/fac/Mitchison.php
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"Timothy J. Mitchison"
Bio:

http://mitchison.med.harvard.edu/Tim_page.html
https://sysbio.med.harvard.edu/facultys/timothy-j-mitchison-phd
http://www.fas.harvard.edu/~biophys/Timothy_J_Mitchison.htm
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.

Cross-listing: Chemistry Tree

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Parents

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Marc W. Kirschner grad student 1984 UCSF
 (Structure and dynamics of organized microtubule arrays)

Children

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Thomas U . grad student Harvard Medical School
Matt Welch grad student UCSF
Julie Theriot grad student 1993 UCSF
Narat J. Eungdamrong grad student 2002 Harvard
Michele Shirasu-Hiza grad student 2003 UCSF
Zoltan Maliga grad student 2004 Harvard
David T. Miyamoto grad student 2004 Harvard
Justin C. Yarrow grad student 2004 Harvard
Zachary E. Perlman grad student 2005 Harvard
Alina M. Vrabioiu grad student 2006 Harvard
Aaron C. Groen grad student 2008 Harvard
Hao Y. Kueh grad student 2008 Harvard
Hsiao-Chun Huang grad student 2010 Harvard
Martin Wühr grad student 2005-2010 Harvard
Chi-Kuo Hu grad student 2011 Harvard
Nefeli E. Georgoulia grad student 2014 Harvard
Arshad Desai post-doc UCSF
Tarun Kapoor post-doc Harvard Medical School
Thomas U. Mayer post-doc
Yuyu Song post-doc Harvard (Neurotree)
Jack Taunton post-doc Harvard Medical School (Chemistry Tree)
Yixian Zheng post-doc UCSF
Ivana Gasic post-doc 2016- Harvard Medical School
Xiang Deng post-doc 2017- Harvard Medical School
Tae Yeon Yoo post-doc 2018- Harvard Medical School
Anthony Hyman post-doc 1993 UCSF
Tatsuya Hirano post-doc 1989-1995 UCSF
Claire Ellen Walczak post-doc 1998 UCSF (Chemistry Tree)
R. Scott Lokey post-doc 2002 Harvard Medical School (Chemistry Tree)
Aaron F. Straight post-doc 2004 Harvard Medical School
Ulrike S. Eggert post-doc 2001-2006 Harvard Medical School (Chemistry Tree)
Paul Chang post-doc 2007 Harvard Medical School (Chemistry Tree)
Daniel J. Needleman post-doc 2005-2008 Harvard (Chemistry Tree)
Ethan C. Garner post-doc 2012 Harvard Medical School

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Publications

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Fang R, Bai L, Li B, et al. (2024) Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation. Biorxiv : the Preprint Server For Biology
Deng X, Seguinot BO, Bradshaw G, et al. (2024) STMND1 is A Phylogenetically Ancient Stathmin which Localizes to Motile Cilia and Exhibits Nuclear Translocation that Is Inhibited When Soluble Tubulin Concentration Increases. Molecular Biology of the Cell. mbcE23120514
Yoo TY, Mitchison TJ. (2024) Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 121: e2307997121
Quek RT, Hardy KS, Walker SG, et al. (2023) Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity. Acs Chemical Biology
Van Itallie ES, Field CM, Mitchison TJ, et al. (2022) Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Developmental Biology. 493: 67-79
Ng TL, Olson EJ, Yoo TY, et al. (2022) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. Msystems. e0146621
Yoo TY, Mitchison T. (2021) Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline. Biorxiv : the Preprint Server For Biology
Mitchison TJ, Field CM. (2021) Self-Organization of Cellular Units. Annual Review of Cell and Developmental Biology
Yoo TY, Mitchison TJ. (2021) O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport. The Journal of Cell Biology. 220
Pelletier JF, Field CM, Fuerthauer S, et al. (2020) Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 9
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