| Year |
Citation |
Score |
| 2023 |
Jakkamsetti V, Ma Q, Angulo G, Scudder W, Beutler B, Pascual JM. Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotion. Biorxiv : the Preprint Server For Biology. PMID 37425744 DOI: 10.1101/2023.06.28.546756 |
0.313 |
|
| 2023 |
Song R, McAlpine W, Fond AM, Nair-Gill E, Choi JH, Nyström EEL, Arike L, Field S, Li X, SoRelle JA, Moresco JJ, Moresco EMY, Yates JR, Azadi P, Ni J, ... ... Beutler B, et al. Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nature Communications. 14: 3652. PMID 37339972 DOI: 10.1038/s41467-023-39398-1 |
0.336 |
|
| 2023 |
Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EMY, Butovich IA, Beutler BA, Ufret-Vincenty RL. Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis. Communications Biology. 6: 533. PMID 37198396 DOI: 10.1038/s42003-023-04870-7 |
0.304 |
|
| 2022 |
Khoenkhoen S, Ádori M, Solís-Sayago D, Soulier J, Russell J, Beutler B, Pedersen GK, Karlsson Hedestam GB. IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens. Frontiers in Immunology. 13: 1000755. PMID 36341341 DOI: 10.3389/fimmu.2022.1000755 |
0.352 |
|
| 2022 |
Zhang Z, Jiang Y, Su L, Ludwig S, Zhang X, Tang M, Li X, Anderton P, Zhan X, Choi M, Russell J, Bu CH, Lyon S, Xu D, Hildebrand S, ... ... Beutler B, et al. Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. Cell Metabolism. PMID 36228616 DOI: 10.1016/j.cmet.2022.09.018 |
0.27 |
|
| 2022 |
Zhang Z, Xun Y, Rong S, Yan L, SoRelle JA, Li X, Tang M, Keller K, Ludwig S, Moresco EMY, Beutler B. Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nature Communications. 13: 4136. PMID 35842425 DOI: 10.1038/s41467-022-31812-4 |
0.306 |
|
| 2022 |
Yang MH, Russell JL, Mifune Y, Wang Y, Shi H, Moresco EMY, Siegwart DJ, Beutler B, Boger DL. Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. Journal of Medicinal Chemistry. PMID 35767437 DOI: 10.1021/acs.jmedchem.2c00419 |
0.4 |
|
| 2022 |
Chatenoud L, Marquet C, Valette F, Scott L, Quan J, Bu CH, Hildebrand S, Moresco EMY, Bach JF, Beutler B. Modulation of autoimmune diabetes by ENU-induced mutations in non-obese diabetic mice. Disease Models & Mechanisms. PMID 35502705 DOI: 10.1242/dmm.049484 |
0.326 |
|
| 2022 |
Zhong X, Choi JH, Hildebrand S, Ludwig S, Wang J, Nair-Gill E, Liao TC, Moresco JJ, Liu A, Quan J, Sun Q, Zhang D, Zhan X, Choi M, Li X, ... ... Beutler B, et al. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200128119. PMID 35482923 DOI: 10.1073/pnas.2200128119 |
0.415 |
|
| 2022 |
Rimann I, Gonzalez-Quintial R, Baccala R, Kiosses WB, Teijaro JR, Parker CG, Li X, Beutler B, Kono DH, Theofilopoulos AN. The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200544119. PMID 35349343 DOI: 10.1073/pnas.2200544119 |
0.344 |
|
| 2021 |
Foray AP, Candon S, Hildebrand S, Marquet C, Valette F, Pecquet C, Lemoine S, Langa-Vives F, Dumas M, Hu P, Santamaria P, You S, Lyon S, Scott L, Bu CH, ... ... Beutler B, et al. De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34782469 DOI: 10.1073/pnas.2112032118 |
0.334 |
|
| 2021 |
Jakkamsetti V, Scudder W, Kathote G, Ma Q, Angulo G, Dobariya A, Rosenberg RN, Beutler B, Pascual JM. Author Correction: Quantification of early learning and movement sub-structure predictive of motor performance. Scientific Reports. 11: 19762. PMID 34588610 DOI: 10.1038/s41598-021-99461-z |
0.177 |
|
| 2021 |
Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T, Beutler B. Sulfatides are endogenous ligands for the TLR4-MD-2 complex. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34290146 DOI: 10.1073/pnas.2105316118 |
0.406 |
|
| 2021 |
Xu D, Lyon S, Bu CH, Hildebrand S, Choi JH, Zhong X, Liu A, Turer EE, Zhang Z, Russell J, Ludwig S, Mahrt E, Nair-Gill E, Shi H, Wang Y, ... ... Beutler B, et al. Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34260399 DOI: 10.1073/pnas.2106786118 |
0.34 |
|
| 2021 |
Jakkamsetti V, Scudder W, Kathote G, Ma Q, Angulo G, Dobariya A, Rosenberg RN, Beutler B, Pascual JM. Quantification of early learning and movement sub-structure predictive of motor performance. Scientific Reports. 11: 14405. PMID 34257385 DOI: 10.1038/s41598-021-93944-9 |
0.216 |
|
| 2021 |
Yang H, Beutler B, Zhang D. Emerging roles of spliceosome in cancer and immunity. Protein & Cell. PMID 34196950 DOI: 10.1007/s13238-021-00856-5 |
0.358 |
|
| 2021 |
Rios JJ, Denton K, Yu H, Manickam K, Garner S, Russell J, Ludwig S, Rosenfeld JA, Liu P, Munch J, Sucato DJ, Beutler B, Wise CA. Saturation mutagenesis defines novel mouse models of severe spine deformity. Disease Models & Mechanisms. 14. PMID 34142127 DOI: 10.1242/dmm.048901 |
0.312 |
|
| 2021 |
Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, ... Beutler B, et al. SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science (New York, N.Y.). 372. PMID 33986151 DOI: 10.1126/science.aba4220 |
0.323 |
|
| 2021 |
Rios JJ, Denton K, Russell J, Kozlitina J, Ferreira CR, Lewanda AF, Mayfield JE, Moresco E, Ludwig S, Tang M, Li X, Lyon S, Khanshour A, Paria N, Khalid A, ... ... Beutler B, et al. Germline saturation mutagenesis induces skeletal phenotypes in mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 33905568 DOI: 10.1002/jbmr.4323 |
0.329 |
|
| 2021 |
Shi H, Sun L, Wang Y, Liu A, Zhan X, Li X, Tang M, Anderton P, Hildebrand S, Quan J, Ludwig S, Moresco EMY, Beutler B. N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Nature Communications. 12: 1379. PMID 33654074 DOI: 10.1038/s41467-021-21711-5 |
0.397 |
|
| 2021 |
Nair-Gill E, Bonora M, Zhong X, Liu A, Miranda A, Stewart N, Ludwig S, Russell J, Gallagher T, Pinton P, Beutler B. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. The Embo Journal. e104888. PMID 33630350 DOI: 10.15252/embj.2020104888 |
0.315 |
|
| 2021 |
Al-Fadhli FM, Afqi M, Sirafi MH, Almuntashri M, Alharby E, Alharbi G, Abdud Samad F, Hashmi JA, Zaytuni D, Bahashwan AA, Choi JH, Peake RWA, Beutler B, Almontashiri NAM. Biallelic Loss of Function Variant in the Unfolded Protein Response Gene PDIA6 is Associated with Asphyxiating Thoracic Dystrophy and Neonatal-Onset Diabetes. Clinical Genetics. PMID 33495992 DOI: 10.1111/cge.13930 |
0.292 |
|
| 2020 |
El Hayek L, Tuncay IO, Nijem N, Russell J, Ludwig S, Kaur K, Li X, Anderton P, Tang M, Gerard A, Heinze A, Zacher P, Alsaif HS, Rad A, Hassanpour K, ... ... Beutler B, et al. mutations identified in autism spectrum disorder using forward genetics. Elife. 9. PMID 33350388 DOI: 10.7554/eLife.56883 |
0.296 |
|
| 2020 |
SoRelle JA, Chen Z, Wang J, Yue T, Choi JH, Wang KW, Zhong X, Hildebrand S, Russell J, Scott L, Xu D, Zhan X, Bu CH, Wang T, Choi M, ... ... Beutler B, et al. Dominant atopy risk mutations identified by mouse forward genetic analysis. Allergy. PMID 32810290 DOI: 10.1111/All.14564 |
0.429 |
|
| 2020 |
Zhan X, Zhong X, Choi JH, Su L, Wang J, Nair-Gill E, Anderton P, Li X, Tang M, Russell J, Ludwig S, Gallagher T, Beutler B. Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood. Blood Advances. 4: 3594-3605. PMID 32761233 DOI: 10.1182/Bloodadvances.2020001762 |
0.414 |
|
| 2020 |
Carbone M, Arron ST, Beutler B, Bononi A, Cavenee W, Cleaver JE, Croce CM, D'Andrea A, Foulkes WD, Gaudino G, Groden JL, Henske EP, Hickson ID, Hwang PM, Kolodner RD, et al. Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nature Reviews. Cancer. PMID 32472073 DOI: 10.1038/S41568-020-0265-Y |
0.385 |
|
| 2020 |
Chen B, Aredo B, Ding Y, Zhong X, Zhu Y, Zhao CX, Kumar A, Xing C, Gautron L, Lyon S, Russell J, Li X, Tang M, Anderton P, Ludwig S, ... ... Beutler B, et al. Forward genetic analysis using OCT screening identifies mutations leading to progressive outer retinal degeneration in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32457148 DOI: 10.1073/Pnas.1921224117 |
0.398 |
|
| 2020 |
Zhang Z, Gallagher T, Scherer PE, Beutler B. Tissue-specific disruption of uncovers adipocyte-intrinsic and -extrinsic features of the lipodystrophy syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 32381739 DOI: 10.1073/Pnas.2000118117 |
0.354 |
|
| 2020 |
Zhong X, Su L, Yang Y, Nair-Gill E, Tang M, Anderton P, Li X, Wang J, Zhan X, Tomchick DR, Brautigam CA, Moresco EMY, Choi JH, Beutler B. Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32220963 DOI: 10.1073/Pnas.2000703117 |
0.46 |
|
| 2020 |
Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B. Essential requirement for nicastrin in marginal zone and B-1 B cell development. Proceedings of the National Academy of Sciences of the United States of America. PMID 32071239 DOI: 10.1073/Pnas.1916645117 |
0.453 |
|
| 2020 |
Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B. Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development. The Journal of Experimental Medicine. 217. PMID 31985756 DOI: 10.1084/Jem.20190006 |
0.479 |
|
| 2020 |
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, ... ... Beutler B, et al. Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. Science Immunology. 5. PMID 31980486 DOI: 10.1126/Sciimmunol.Aaz0085 |
0.415 |
|
| 2020 |
Beutler B, Ulevitch RJ. Genetic Analysis of Host Responses in Sepsis. Current Infectious Disease Reports. 3: 419-426. PMID 11559462 |
0.352 |
|
| 2019 |
Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, McKinnon KP, Beutler B, Ting JP. Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR. The Journal of Experimental Medicine. PMID 31558613 DOI: 10.1084/Jem.20190111 |
0.414 |
|
| 2019 |
McAlpine W, Russell J, Murray AR, Beutler B, Turer E. Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology. The Journal of Investigative Dermatology. 139: 1848-1853.e1. PMID 31445571 DOI: 10.1016/J.Jid.2019.04.013 |
0.413 |
|
| 2019 |
Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B. Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40. Nature Immunology. PMID 31427773 DOI: 10.1038/S41590-019-0464-4 |
0.47 |
|
| 2019 |
Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, ... ... Beutler B, et al. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31289229 DOI: 10.1073/Pnas.1904360116 |
0.404 |
|
| 2019 |
Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, ... ... Beutler B, et al. Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 31097594 DOI: 10.1073/Pnas.1901407116 |
0.536 |
|
| 2019 |
Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, ... ... Beutler B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science (New York, N.Y.). 364. PMID 31073040 DOI: 10.1126/Science.Aau0812 |
0.432 |
|
| 2019 |
Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EM, Boger DL, Beutler B, Zhang H. Structural basis of TLR2/TLR1 activation by the synthetic agonist Diprovocim. Journal of Medicinal Chemistry. PMID 30829478 DOI: 10.2210/Pdb6Nig/Pdb |
0.449 |
|
| 2019 |
SoRelle JA, Misawa T, Chen Z, HIldebrand S, Wang J, Yue T, Choi JH, Wang K, Zhong X, Russell J, Scott L, Wang T, Zhan X, Bu CH, Moresco EM, ... Beutler B, et al. Forward Genetic Screen Reveals Genetic Causes of Atopy Journal of Allergy and Clinical Immunology. 143: AB204. DOI: 10.1016/J.Jaci.2018.12.624 |
0.34 |
|
| 2018 |
Turer EE, San Miguel M, Wang KW, McAlpine W, Ou F, Li X, Tang M, Zang Z, Wang J, Hayse B, Evers B, Zhan X, Russell J, Beutler B. A viable hypomorphic mutation causes hyperphagic obesity, diabetes and hepatic steatosis. Disease Models & Mechanisms. 11. PMID 30563851 DOI: 10.1242/Dmm.035451 |
0.41 |
|
| 2018 |
McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, ... ... Beutler B, et al. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30442666 DOI: 10.1073/Pnas.1814753115 |
0.514 |
|
| 2018 |
McAlpine W, Wang KW, Choi JH, San Miguel M, McAlpine SG, Russell J, Ludwig S, Li X, Tang M, Zhan X, Choi M, Wang T, Bu CH, Murray AR, Moresco EMY, ... ... Beutler B, et al. The class I myosin MYO1D binds to lipid and protects against colitis. Disease Models & Mechanisms. 11. PMID 30279225 DOI: 10.1242/Dmm.035923 |
0.411 |
|
| 2018 |
Morin MD, Wang Y, Jones BT, Mifune Y, Su L, Shi H, Moresco EMY, Zhang H, Beutler B, Boger DL. Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. Journal of the American Chemical Society. PMID 30272974 DOI: 10.1021/Jacs.8B09223 |
0.48 |
|
| 2018 |
Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, ... ... Beutler B, et al. Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150374 DOI: 10.1073/Pnas.1809232115 |
0.486 |
|
| 2018 |
Pedersen GK, Li X, Khoenkhoen S, Ádori M, Beutler B, Karlsson Hedestam GB. B-1a Cell Development in Splenectomized Neonatal Mice. Frontiers in Immunology. 9: 1738. PMID 30105023 DOI: 10.3389/Fimmu.2018.01738 |
0.368 |
|
| 2018 |
Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, ... ... Beutler B, et al. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nature Communications. 9: 2041. PMID 29795268 DOI: 10.1038/S41467-018-04324-3 |
0.402 |
|
| 2018 |
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, ... Beutler B, et al. Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. The Journal of Clinical Investigation. PMID 29457786 DOI: 10.1172/Jci97702 |
0.362 |
|
| 2018 |
Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B. Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nature Communications. 9: 441. PMID 29382827 DOI: 10.1038/S41467-017-02806-4 |
0.401 |
|
| 2018 |
Turer EE, Wang K, McAlpine W, Beutler B. Tu1793 - Rapid and Automated Mapping of Genes Critical for Intestinal Homeostasis Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)33419-X |
0.337 |
|
| 2017 |
Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB. Altered Marginal Zone B Cell Selection in the Absence of IκBNS. Journal of Immunology (Baltimore, Md. : 1950). PMID 29222168 DOI: 10.4049/Jimmunol.1700791 |
0.416 |
|
| 2017 |
Pollard KM, Escalante GM, Huang H, Haraldsson KM, Hultman P, Christy JM, Pawar RD, Mayeux JM, Gonzalez-Quintial R, Baccala R, Beutler B, Theofilopoulos AN, Kono DH. Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN. Journal of Immunology (Baltimore, Md. : 1950). PMID 29055005 DOI: 10.4049/Jimmunol.1700332 |
0.46 |
|
| 2017 |
Mager LF, Koelzer V, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister S, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, ... ... Beutler B, et al. The ESRP1-GPR137 axis contributes to intestinal pathogenesis. Elife. 6. PMID 28975893 DOI: 10.7554/Elife.28366 |
0.405 |
|
| 2017 |
Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, ... ... Beutler B, et al. HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. The Journal of Experimental Medicine. PMID 28970238 DOI: 10.1084/Jem.20161630 |
0.62 |
|
| 2017 |
Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, ... ... Beutler B, et al. An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue. Scientific Reports. 7: 11717. PMID 28916811 DOI: 10.1038/S41598-017-10343-9 |
0.419 |
|
| 2017 |
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, ... Beutler B, et al. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proceedings of the National Academy of Sciences of the United States of America. PMID 28607088 DOI: 10.1073/Pnas.1705312114 |
0.377 |
|
| 2017 |
Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, ... ... Beutler B, et al. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell. 168: 789-800.e10. PMID 28235196 DOI: 10.1016/J.Cell.2017.01.039 |
0.485 |
|
| 2017 |
Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, ... ... Beutler B, et al. IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137874 DOI: 10.1073/Pnas.1621258114 |
0.452 |
|
| 2017 |
Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, Zhan X, Wang T, Zhan X, Bu CH, Murray AR, Beutler B. Creatine maintains intestinal homeostasis and protects against colitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137860 DOI: 10.1073/Pnas.1621400114 |
0.431 |
|
| 2017 |
Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2/ADAM17-dependent proteolysis. Journal of Cell Science. PMID 28104813 DOI: 10.1242/Jcs.196436 |
0.443 |
|
| 2017 |
Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, ... ... Beutler B, et al. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. The Journal of Experimental Medicine. PMID 28057804 DOI: 10.1084/Jem.20160869 |
0.406 |
|
| 2017 |
Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, ... ... Beutler B, et al. Author response: The ESRP1-GPR137 axis contributes to intestinal pathogenesis Elife. DOI: 10.7554/Elife.28366.045 |
0.369 |
|
| 2016 |
Shi H, Murray A, Beutler B. Reconstruction of the Mouse Inflammasome System in HEK293T Cells. Bio-Protocol. 6. PMID 28516117 DOI: 10.21769/BioProtoc.1986 |
0.27 |
|
| 2016 |
Beutler BA. Innate immunity and the new forward genetics. Best Practice & Research Clinical Haematology. 29: 379-387. PMID 27890263 DOI: 10.1016/J.Beha.2016.10.018 |
0.449 |
|
| 2016 |
Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 27708159 DOI: 10.1073/Pnas.1614467113 |
0.4 |
|
| 2016 |
Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AA, ... ... Beutler B, et al. K(+) Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity. PMID 27692612 DOI: 10.1016/J.Immuni.2016.08.010 |
0.408 |
|
| 2016 |
Beutler B. Finding New Components of the Mammalian Immune System. Rambam Maimonides Medical Journal. 7. PMID 27487306 DOI: 10.5041/Rmmj.10245 |
0.417 |
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| 2016 |
Wang JQ, Beutler B, Goodnow CC, Horikawa K. Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. Blood. PMID 27458005 DOI: 10.1182/Blood-2016-03-708065 |
0.478 |
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| 2016 |
Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, ... ... Beutler B, et al. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303042 DOI: 10.1073/Pnas.1607592113 |
0.439 |
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| 2016 |
Morin MD, Wang Y, Jones BT, Su L, Surakattula MM, Berger M, Huang H, Beutler EK, Zhang H, Beutler B, Boger DL. Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists. Journal of Medicinal Chemistry. PMID 27050713 DOI: 10.1021/Acs.Jmedchem.6B00177 |
0.449 |
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| 2016 |
Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MMRP, Huang H, Shi H, Choi JH, Wang KW, Moresco EMY, Berger M, Zhan X, Zhang H, Boger DL, ... Beutler B, et al. Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893)) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 27036010 DOI: 10.1073/Pnas.1603716113 |
0.388 |
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| 2016 |
Pedersen GK, Ádori M, Stark JM, Khoenkhoen S, Arnold C, Beutler B, Karlsson Hedestam GB. Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens. Frontiers in Immunology. 7: 65. PMID 26973645 DOI: 10.3389/Fimmu.2016.00065 |
0.459 |
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| 2016 |
Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, ... Beutler B, et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831104 DOI: 10.1073/Pnas.1525639113 |
0.471 |
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| 2016 |
Beutler BA. Pathogens, Commensals, and Immunity: From the Perspective of the Urinary Bladder Pathogenetics. 5: 5. DOI: 10.3390/Pathogens5010005 |
0.447 |
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| 2016 |
Scatizzi JC, Huang H, Beutler B, Theofilopoulos AN, Kono DH. AI-21 Defective ikappabns leads to loss of peritoneal B1 cells and a reduction in induced but not spontaneous autoimmune hemolytic anaemia Lupus Science & Medicine. 3. DOI: 10.1136/Lupus-2016-000179.21 |
0.45 |
|
| 2015 |
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, ... ... Beutler B, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nature Immunology. PMID 26642356 DOI: 10.1038/Ni.3333 |
0.418 |
|
| 2015 |
Simon MM, Moresco EM, Bull KR, Kumar S, Mallon AM, Beutler B, Potter PK. Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 26449678 DOI: 10.1007/S00335-015-9603-X |
0.415 |
|
| 2015 |
Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ, Beutler B. Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438836 DOI: 10.1073/Pnas.1515619112 |
0.468 |
|
| 2015 |
Ronald PC, Beutler B. Erratum: Plant and animal sensors of conserved microbial signatures (Science (2015) 330:6007 (1061-1064)) Science. 349: 3218. PMID 26359405 DOI: 10.1126/Science.Aad3218 |
0.309 |
|
| 2015 |
Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, et al. Comparison of predicted and actual consequences of missense mutations. Proceedings of the National Academy of Sciences of the United States of America. 112: E5189-98. PMID 26269570 DOI: 10.1073/Pnas.1511585112 |
0.421 |
|
| 2015 |
Mager LF, Riether C, Schürch CM, Banz Y, Wasmer MH, Stuber R, Theocharides AP, Li X, Xia Y, Saito H, Nakae S, Baerlocher GM, Manz MG, McCoy KD, Macpherson AJ, ... ... Beutler B, et al. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. The Journal of Clinical Investigation. 125: 2579-91. PMID 26011644 DOI: 10.1172/Jci77347 |
0.397 |
|
| 2015 |
von Hertzen L, Beutler B, Bienenstock J, Blaser M, Cani PD, Eriksson J, Färkkilä M, Haahtela T, Hanski I, Jenmalm MC, Kere J, Knip M, Kontula K, Koskenvuo M, Ling C, et al. Helsinki alert of biodiversity and health. Annals of Medicine. 47: 218-25. PMID 25904094 DOI: 10.3109/07853890.2015.1010226 |
0.398 |
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| 2015 |
Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, ... ... Beutler B, et al. Real-time resolution of point mutations that cause phenovariance in mice. Proceedings of the National Academy of Sciences of the United States of America. 112: E440-9. PMID 25605905 DOI: 10.1073/Pnas.1423216112 |
0.442 |
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| 2015 |
Dosenovic P, Ádori M, Adams WC, Pedersen GK, Soldemo M, Beutler BA, Hedestam GBK. Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunology and Cell Biology. 93: 136-146. PMID 25310967 DOI: 10.1038/Icb.2014.82 |
0.477 |
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| 2015 |
Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA. Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity. 21: 175-93. PMID 24591200 DOI: 10.1177/1753425914524077 |
0.408 |
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| 2014 |
Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, ... ... Beutler B, et al. MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science (New York, N.Y.). 346: 1486-92. PMID 25525240 DOI: 10.1126/Science.346.6216.1486 |
0.438 |
|
| 2014 |
Pedersen GK, Àdori M, Khoenkhoen S, Dosenovic P, Beutler B, Karlsson Hedestam GB. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proceedings of the National Academy of Sciences of the United States of America. 111: E4119-26. PMID 25228759 DOI: 10.1073/pnas.1415866111 |
0.293 |
|
| 2014 |
Rommelaere S, Millet V, Vu Manh TP, Gensollen T, Andreoletti P, Cherkaoui-Malki M, Bourges C, Escalière B, Du X, Xia Y, Imbert J, Beutler B, Kanai Y, Malissen B, Malissen M, et al. Sox17 regulates liver lipid metabolism and adaptation to fasting. Plos One. 9: e104925. PMID 25141153 DOI: 10.1371/Journal.Pone.0104925 |
0.407 |
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| 2014 |
Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AV, ... ... Beutler B, et al. RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. Journal of Immunology (Baltimore, Md. : 1950). 192: 5963-73. PMID 24813206 DOI: 10.4049/Jimmunol.1303058 |
0.442 |
|
| 2014 |
Chen Z, Holland W, Shelton JM, Ali A, Zhan X, Won S, Tomisato W, Liu C, Li X, Moresco EM, Beutler B. Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 7367-72. PMID 24799716 DOI: 10.1073/Pnas.1406511111 |
0.421 |
|
| 2014 |
Wang JQ, Jeelall YS, Beutler B, Horikawa K, Goodnow CC. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. The Journal of Experimental Medicine. 211: 413-26. PMID 24534189 DOI: 10.1084/Jem.20131424 |
0.473 |
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| 2014 |
Garrison SR, Weyer AD, Barabas ME, Beutler BA, Stucky CL. A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons. Pain. 155: 896-905. PMID 24447515 DOI: 10.1016/J.Pain.2014.01.012 |
0.361 |
|
| 2014 |
Pedersen GK, Àdori M, Khoenkhoen S, Dosenovic P, Beutler B, Karlsson Hedestam GB. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS Proceedings of the National Academy of Sciences of the United States of America. 111: E4119-E4126. DOI: 10.1073/Pnas.1415866111 |
0.393 |
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| 2013 |
Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B. Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice". Nature Immunology. 14: 1102-3. PMID 24145779 DOI: 10.1038/Ni.2734 |
0.333 |
|
| 2013 |
Beutler B. A conversation with Bruce Beutler. Interview by Ushma S. Neill. The Journal of Clinical Investigation. 123: 3637-8. PMID 23999435 DOI: 10.1172/JCI71317 |
0.172 |
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| 2013 |
Beutler B. The central answer. Interview by Kristie Nybo Biotechniques. 54: 241. PMID 23805428 |
0.187 |
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| 2013 |
Moresco EM, Li X, Beutler B. Going forward with genetics: recent technological advances and forward genetics in mice. The American Journal of Pathology. 182: 1462-73. PMID 23608223 DOI: 10.1016/J.Ajpath.2013.02.002 |
0.402 |
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| 2013 |
Koh YT, Scatizzi JC, Gahan JD, Lawson BR, Baccala R, Pollard KM, Beutler BA, Theofilopoulos AN, Kono DH. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. Journal of Immunology (Baltimore, Md. : 1950). 190: 4982-90. PMID 23589617 DOI: 10.4049/Jimmunol.1202986 |
0.459 |
|
| 2013 |
Teh CE, Horikawa K, Arnold CN, Beutler B, Kucharska EM, Vinuesa CG, Bertram EM, Goodnow CC, Enders A. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation Genes and Immunity. 14: 223-233. PMID 23552399 DOI: 10.1038/Gene.2013.11 |
0.445 |
|
| 2013 |
Beutler B. Bruce Beutler wins the 2013 ASCI/Stanley J. Korsmeyer Award. Interview by Kathryn Claiborn The Journal of Clinical Investigation. 123: 1403-1404. PMID 23543061 DOI: 10.1172/Jci69412 |
0.362 |
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| 2013 |
Beutler B. Bruce Beutler: the persistent prospector. Interview by Ruth Williams Circulation Research. 112: 751-754. PMID 23449544 DOI: 10.1161/CIRCRESAHA.113.301093 |
0.2 |
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| 2013 |
Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, et al. Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. Plos Genetics. 9: e1003219. PMID 23382690 DOI: 10.1371/Journal.Pgen.1003219 |
0.415 |
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| 2013 |
Baccala R, Gonzalez-Quintial R, Blasius AL, Rimann I, Ozato K, Kono DH, Beutler B, Theofilopoulos AN. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proceedings of the National Academy of Sciences of the United States of America. 110: 2940-5. PMID 23382217 DOI: 10.1073/Pnas.1222798110 |
0.5 |
|
| 2013 |
Beutler B. The central answer Biotechniques. 54: 241. DOI: 10.2144/000114023 |
0.194 |
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| 2012 |
Brandl K, Beutler B. Creating diseases to understand what prevents them: Genetic analysis of inflammation in the gastrointestinal tract Current Opinion in Immunology. 24: 678-685. PMID 23123276 DOI: 10.1016/J.Coi.2012.10.005 |
0.421 |
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| 2012 |
Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, ... ... Beutler B, et al. ENU-induced phenovariance in mice: inferences from 587 mutations. Bmc Research Notes. 5: 577. PMID 23095377 DOI: 10.1186/1756-0500-5-577 |
0.413 |
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| 2012 |
Siggs OM, Beutler B. The BTB-ZF transcription factors Cell Cycle. 11: 3358-3369. PMID 22894929 DOI: 10.4161/Cc.21277 |
0.43 |
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| 2012 |
Siggs OM, Cruite JT, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone MB. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proceedings of the National Academy of Sciences of the United States of America. 109: 13733-8. PMID 22869751 DOI: 10.1073/Pnas.1211499109 |
0.393 |
|
| 2012 |
Brandl K, Tomisato W, Li X, Neppl C, Pirie E, Falk W, Xia Y, Moresco EM, Baccala R, Theofilopoulos AN, Schnabl B, Beutler B. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 12650-5. PMID 22802641 DOI: 10.1073/Pnas.1210366109 |
0.455 |
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| 2012 |
Beutler B. QnAs with Bruce Beutler. Interview by Nicholette Zeliadt. Proceedings of the National Academy of Sciences of the United States of America. 109: 12265. PMID 22802631 DOI: 10.1073/pnas.1210583109 |
0.164 |
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| 2012 |
Arnold CN, Pirie E, Dosenovic P, McInerney GM, Xia Y, Wang N, Li X, Siggs OM, Karlsson Hedestam GB, Beutler B. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proceedings of the National Academy of Sciences of the United States of America. 109: 12286-93. PMID 22761313 DOI: 10.1073/Pnas.1209134109 |
0.454 |
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| 2012 |
Andrews TD, Whittle B, Field MA, Balakishnan B, Zhang Y, Shao Y, Cho V, Kirk M, Singh M, Xia Y, Hager J, Winslade S, Sjollema G, Beutler B, Enders A, et al. Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: An immediate source for thousands of new mouse models Open Biology. 2. PMID 22724066 DOI: 10.1098/Rsob.120061 |
0.427 |
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| 2012 |
Siggs OM, Xiao N, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B. iRhom2 is required for the secretion of mouse TNFα Blood. 119: 5769-5771. PMID 22550345 DOI: 10.1182/Blood-2012-03-417949 |
0.491 |
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| 2012 |
Rutschmann S, Crozat K, Li X, Du X, Hanselman JC, Shigeoka AA, Brandl K, Popkin DL, McKay DB, Xia Y, Moresco EM, Beutler B. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda, Md.). 2: 499-504. PMID 22540041 DOI: 10.1534/G3.112.002196 |
0.418 |
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| 2012 |
Narni-Mancinelli E, Jaeger BN, Bernat C, Fenis A, Kung S, De Gassart A, Mahmood S, Gut M, Heath SC, Estellé J, Bertosio E, Vely F, Gastinel LN, Beutler B, Malissen B, et al. Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (New York, N.Y.). 335: 344-8. PMID 22267813 DOI: 10.1126/Science.1215621 |
0.458 |
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| 2012 |
Brandl K, Tomisato W, Beutler B. Inflammatory bowel disease and ADAM17 deletion New England Journal of Medicine. 366: 190. PMID 22236242 DOI: 10.1056/Nejmc1113859 |
0.436 |
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| 2012 |
Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EM, Beutler B. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. Journal of Virology. 86: 1802-8. PMID 22114338 DOI: 10.1128/Jvi.05660-11 |
0.428 |
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| 2012 |
Hartmann P, Brandl K, Hellerbrand C, Tsukamoto H, Ho SB, Beutler B, Schnabl B. 928 Deficiency of Intestinal Mucin-2 Protects From Alcoholic Liver Disease in Mice Gastroenterology. 142: S-935. DOI: 10.1016/S0016-5085(12)63626-9 |
0.374 |
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| 2011 |
Moresco EM, Beutler B. Resisting viral infection: the gene by gene approach. Current Opinion in Virology. 1: 513-8. PMID 22440911 DOI: 10.1016/J.Coviro.2011.10.005 |
0.445 |
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| 2011 |
Siggs OM, Li X, Xia Y, Beutler B. ZBTB1 is a determinant of lymphoid development. The Journal of Experimental Medicine. 209: 19-27. PMID 22201126 DOI: 10.1084/Jem.20112084 |
0.433 |
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| 2011 |
Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, ... ... Beutler B, et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proceedings of the National Academy of Sciences of the United States of America. 108: 19678-82. PMID 22106289 DOI: 10.1073/Pnas.1117835108 |
0.385 |
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| 2011 |
Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proceedings of the National Academy of Sciences of the United States of America. 108: 19413-8. PMID 22087007 DOI: 10.1073/Pnas.1117020108 |
0.606 |
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| 2011 |
Theofilopoulos AN, Kono DH, Beutler B, Baccala R. Intracellular nucleic acid sensors and autoimmunity Journal of Interferon and Cytokine Research. 31: 867-886. PMID 22029446 DOI: 10.1089/Jir.2011.0092 |
0.375 |
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| 2011 |
Krieg L, Milstein O, Krebs P, Xia Y, Beutler B, Du X. Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice Blood. 118: 6418-6425. PMID 21976678 DOI: 10.1182/Blood-2011-04-350082 |
0.35 |
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| 2011 |
Moresco EM, Vine DL, Beutler B. Prion-like behavior of MAVS in RIG-I signaling. Cell Research. 21: 1643-5. PMID 21931357 DOI: 10.1038/Cr.2011.155 |
0.421 |
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| 2011 |
Xia CH, Lu E, Liu H, Du X, Beutler B, Gong X. The role of Vldlr in intraretinal angiogenesis in mice. Investigative Ophthalmology & Visual Science. 52: 6572-9. PMID 21757581 DOI: 10.1167/Iovs.10-7082 |
0.421 |
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| 2011 |
Moresco EM, LaVine D, Beutler B. Toll-like receptors. Current Biology : Cb. 21: R488-93. PMID 21741580 DOI: 10.1016/J.Cub.2011.05.039 |
0.453 |
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| 2011 |
Eleftherianos I, Won S, Chtarbanova S, Squiban B, Ocorr K, Bodmer R, Beutler B, Hoffmann JA, Imler JL. ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections. Proceedings of the National Academy of Sciences of the United States of America. 108: 12024-9. PMID 21719711 DOI: 10.1073/Pnas.1108926108 |
0.369 |
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| 2011 |
Zak DE, Schmitz F, Gold ES, Diercks AH, Peschon JJ, Valvo JS, Niemistö A, Podolsky I, Fallen SG, Suen R, Stolyar T, Johnson CD, Kennedy KA, Hamilton MK, Siggs OM, ... Beutler B, et al. Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proceedings of the National Academy of Sciences of the United States of America. 108: 11536-41. PMID 21709223 DOI: 10.1073/Pnas.1107577108 |
0.513 |
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| 2011 |
Krebs P, Crozat K, Popkin D, Oldstone MB, Beutler B. Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood. 117: 6582-8. PMID 21551232 DOI: 10.1182/Blood-2011-01-329607 |
0.516 |
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| 2011 |
Siggs OM, Schnabl B, Webb B, Beutler B. X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C Proceedings of the National Academy of Sciences of the United States of America. 108: 7890-7895. PMID 21518881 DOI: 10.1073/Pnas.1104631108 |
0.416 |
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| 2011 |
Moresco EM, Beutler B. Special delivery: granulin brings CpG DNA to Toll-like receptor 9. Immunity. 34: 453-5. PMID 21511177 DOI: 10.1016/J.Immuni.2011.04.001 |
0.447 |
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| 2011 |
Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nature Immunology. 12: 434-40. PMID 21423172 DOI: 10.1038/Ni.2012 |
0.376 |
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| 2011 |
Popkin DL, Teijaro JR, Sullivan BM, Urata S, Rutschmann S, de la Torre JC, Kunz S, Beutler B, Oldstone M. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host & Microbe. 9: 212-22. PMID 21402360 DOI: 10.1016/J.Chom.2011.02.006 |
0.4 |
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| 2011 |
Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A. A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding. Journal of Immunology (Baltimore, Md. : 1950). 186: 4213-22. PMID 21383246 DOI: 10.4049/Jimmunol.1003585 |
0.488 |
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| 2011 |
Beutler S, Beutler B. Ernest Beutler: His life and contribution to medical science British Journal of Haematology. 152: 543-550. PMID 21241280 DOI: 10.1111/J.1365-2141.2010.08542.X |
0.347 |
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| 2011 |
Crozat K, Eidenschenk C, Jaeger BN, Krebs P, Guia S, Beutler B, Vivier E, Ugolini S. Impact of β2 integrin deficiency on mouse natural killer cell development and function Blood. 117: 2874-2882. PMID 21239699 DOI: 10.1182/Blood-2010-10-315457 |
0.447 |
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| 2011 |
Arnold CN, Xia Y, Lin P, Ross C, Schwander M, Smart NG, Müller U, Beutler B. Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis. Genetics. 187: 633-41. PMID 21196518 DOI: 10.1534/Genetics.110.124586 |
0.408 |
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| 2011 |
Beutler B, Goodnow CC. How host defense is encoded in the mammalian genome Mammalian Genome. 22: 1-5. PMID 21184083 DOI: 10.1007/S00335-010-9312-4 |
0.391 |
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| 2011 |
Brandl K, Tomisato W, Neppl C, Pirie E, Schnabl B, Beutler B. Modeling IBD in the mouse through random germline mutagenesis: P-173. Inflammatory Bowel Diseases. 17. DOI: 10.1097/00054725-201112002-00207 |
0.332 |
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| 2011 |
Brandl K, Tomisato W, Beutler B. Forward Genetic Analysis of Gut Homeostasis Using a Sensitized Screen in Mice Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61096-2 |
0.379 |
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| 2010 |
Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 107: 22122-7. PMID 21135226 DOI: 10.1073/Pnas.1016401107 |
0.404 |
|
| 2010 |
Ronald PC, Beutler B. Plant and animal sensors of conserved microbial signatures Science. 330: 1061-1064. PMID 21097929 DOI: 10.1126/Science.1189468 |
0.362 |
|
| 2010 |
Blasius AL, Arnold CN, Georgel P, Rutschmann S, Xia Y, Lin P, Ross C, Li X, Smart NG, Beutler B. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 19973-8. PMID 21045126 DOI: 10.1073/Pnas.1014051107 |
0.497 |
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| 2010 |
Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li X, Du X, Maennel DN, Blobel CP, Beutler B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Proceedings of the National Academy of Sciences of the United States of America. 107: 19967-19972. PMID 21041656 DOI: 10.1073/Pnas.1014669107 |
0.495 |
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| 2010 |
Xia Y, Won S, Du X, Lin P, Ross C, La Vine D, Wiltshire S, Leiva G, Vidal SM, Whittle B, Goodnow CC, Koziol J, Moresco EMY, Beutler B. Bulk segregation mapping of mutations in closely related strains of mice Genetics. 186: 1139-1145. PMID 20923982 DOI: 10.1534/Genetics.110.121160 |
0.384 |
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| 2010 |
Melo MB, Kasperkovitz P, Cerny A, Könen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT. UNC93B1 mediates host resistance to infection with toxoplasma gondii Plos Pathogens. 6: 83-84. PMID 20865117 DOI: 10.1371/Journal.Ppat.1001071 |
0.493 |
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| 2010 |
Wingender G, Krebs P, Beutler B, Kronenberg M. Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency Journal of Immunology. 185: 2721-2729. PMID 20660713 DOI: 10.4049/Jimmunol.1001018 |
0.391 |
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| 2010 |
Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, Scheller M, Rosenstiel P, Goldmann T, Bollinger A, Beutler BA, Bulfone-Paus S. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood. 116: 2665-75. PMID 20595514 DOI: 10.1182/Blood-2009-06-228460 |
0.411 |
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| 2010 |
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 9759-64. PMID 20457904 DOI: 10.1073/Pnas.1005186107 |
0.461 |
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| 2010 |
Blasius AL, Beutler B. Intracellular Toll-like Receptors Immunity. 32: 305-315. PMID 20346772 DOI: 10.1016/J.Immuni.2010.03.012 |
0.489 |
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| 2010 |
Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco EM, Satoh T, Takeuchi O, ... ... Beutler B, et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nature Immunology. 11: 335-43. PMID 20190759 DOI: 10.1038/Ni.1847 |
0.478 |
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| 2010 |
Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, ... ... Beutler B, et al. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 3743-54. PMID 20190135 DOI: 10.4049/Jimmunol.0903164 |
0.48 |
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| 2010 |
Theofilopoulos AN, Gonzalez-Quintial R, Lawson BR, Koh YT, Stern ME, Kono DH, Beutler B, Baccala R. Sensors of the innate immune system: their link to rheumatic diseases. Nature Reviews. Rheumatology. 6: 146-56. PMID 20142813 DOI: 10.1038/Nrrheum.2009.278 |
0.461 |
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| 2010 |
Moresco EM, Beutler B. LGP2: positive about viral sensing. Proceedings of the National Academy of Sciences of the United States of America. 107: 1261-2. PMID 20133887 DOI: 10.1073/Pnas.0914011107 |
0.366 |
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| 2010 |
Siggs OM, Berger M, Krebs P, Arnold CN, Eidenschenk C, Huber C, Pirie E, Smart NG, Khovananth K, Xia Y, McInerney G, Karlsson Hedestam GB, Nemazee D, Beutler B. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proceedings of the National Academy of Sciences of the United States of America. 107: 3046-51. PMID 20133626 DOI: 10.1073/Pnas.0915098107 |
0.492 |
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| 2010 |
Liu H, Wang M, Xia CH, Du X, Flannery JG, Ridge KD, Beutler B, Gong X. Severe retinal degeneration caused by a novel rhodopsin mutation. Investigative Ophthalmology & Visual Science. 51: 1059-65. PMID 19741247 DOI: 10.1167/Iovs.09-3585 |
0.404 |
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| 2010 |
Osborn O, Sanchez-Alavez M, Brownell SE, Ross B, Klaus J, Dubins J, Beutler B, Conti B, Bartfai T. Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cellular and Molecular Neurobiology. 30: 23-33. PMID 19582570 DOI: 10.1007/S10571-009-9427-X |
0.408 |
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| 2009 |
Kiemer AK, Senaratne RH, Hoppstädter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw BL. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. Journal of Innate Immunity. 1: 29-45. PMID 20375564 DOI: 10.1159/000142731 |
0.489 |
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| 2009 |
Xiao N, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B. The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease Journal of Immunology. 183: 7975-7983. PMID 19923465 DOI: 10.4049/Jimmunol.0902718 |
0.503 |
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| 2009 |
Flür K, Allam R, Zecher D, Kulkarni OP, Lichtnekert J, Schwarz M, Beutler B, Vielhauer V, Anders HJ. Viral RNA induces type i interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis American Journal of Pathology. 175: 2014-2022. PMID 19850889 DOI: 10.2353/Ajpath.2009.080585 |
0.448 |
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| 2009 |
Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. Plos One. 4: e7411. PMID 19847289 DOI: 10.1371/Journal.Pone.0007411 |
0.446 |
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| 2009 |
Truksa J, Gelbart T, Peng H, Beutler E, Beutler B, Lee P. Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6 British Journal of Haematology. 147: 571-581. PMID 19751239 DOI: 10.1111/J.1365-2141.2009.07873.X |
0.512 |
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| 2009 |
Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P, Verdu EF, McCoy KD, Macpherson AJ. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (New York, N.Y.). 325: 617-20. PMID 19644121 DOI: 10.1126/Science.1172747 |
0.451 |
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| 2009 |
Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B, Theofilopoulos AN. Sensors of the innate immune system: their mode of action. Nature Reviews. Rheumatology. 5: 448-56. PMID 19597511 DOI: 10.1038/Nrrheum.2009.136 |
0.424 |
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| 2009 |
Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA, Theofilopoulos AN. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proceedings of the National Academy of Sciences of the United States of America. 106: 12061-6. PMID 19574451 DOI: 10.1073/Pnas.0905441106 |
0.468 |
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| 2009 |
Fukui R, Saitoh SI, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing Journal of Experimental Medicine. 206: 1339-1350. PMID 19451267 DOI: 10.1084/Jem.20082316 |
0.486 |
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| 2009 |
Borelli P, Barros FE, Nakajima K, Blatt SL, Beutler B, Pereira J, Tsujita M, Favero GM, Fock RA. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 42: 523-30. PMID 19448901 DOI: 10.1590/S0100-879X2009000600008 |
0.369 |
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| 2009 |
Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses Blood. 113: 6593-6602. PMID 19406986 DOI: 10.1182/Blood-2009-01-201467 |
0.445 |
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| 2009 |
Pflugfelder SC, Stern ME, Beutler BA, Burns AR, Calonge M, Chodosh J, Dana MR, De Paiva CS, Fleiszig S, Hazlett LD, Huang AJ, Jones DB, Liu YJ, McDermott AM, Mircheff AK, et al. Immunoregulation on the ocular surface: 2nd cullen symposium Ocular Surface. 7: 67-77. PMID 19383275 DOI: 10.1016/S1542-0124(12)70297-5 |
0.421 |
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| 2009 |
Barnes MJ, Krebs P, Harris N, Eidenschenk C, Gonzalez-Quintial R, Arnold CN, Crozat K, Sovath S, Moresco EM, Theofilopoulos AN, Beutler B, Hoebe K. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. Plos Biology. 7: e51. PMID 19260764 DOI: 10.1371/Journal.Pbio.1000051 |
0.414 |
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| 2009 |
Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Proceedings of the National Academy of Sciences of the United States of America. 106: 3300-3305. PMID 19202076 DOI: 10.1073/Pnas.0813036106 |
0.415 |
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| 2009 |
Blasius AL, Brandl K, Crozat K, Xia Y, Khovananth K, Krebs P, Smart NG, Zampolli A, Ruggeri ZM, Beutler BA. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proceedings of the National Academy of Sciences of the United States of America. 106: 2706-11. PMID 19202056 DOI: 10.1073/Pnas.0813208106 |
0.396 |
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| 2009 |
Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ. Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif American Journal of Physiology - Renal Physiology. 296: F867-F874. PMID 19158348 DOI: 10.1152/Ajprenal.90213.2008 |
0.494 |
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| 2009 |
Beutler B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases Immunological Reviews. 227: 248-263. PMID 19120489 DOI: 10.1111/J.1600-065X.2008.00733.X |
0.493 |
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| 2009 |
Beutler B. Obituary: Ernest Beutler (1928-2008) Haematologica. 94: 154-156. PMID 19118377 DOI: 10.3324/Haematol.13863 |
0.292 |
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| 2009 |
Beutler BA. TLRs and innate immunity. Blood. 113: 1399-407. PMID 18757776 DOI: 10.1182/Blood-2008-07-019307 |
0.467 |
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| 2009 |
Beutler BA. Cachexia: a Fundamental Mechanism Nutrition Reviews. 46: 369-373. PMID 3070440 DOI: 10.1111/J.1753-4887.1988.Tb05370.X |
0.302 |
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| 2009 |
Brandl K, Rutschmann S, Schnabl B, Beutler B. S1634 Inadequate Unfolded Protein Response As a Mechanism for Acute Colitis in Mbtps1 Mutant Mice Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)61080-5 |
0.387 |
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| 2009 |
Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K. Unc93 homolog B1 regulates the balance of toll-like receptor 7 and toll-like receptor 9 responses reciprocally in dendritic cells Cytokine. 48: 26. DOI: 10.1016/J.Cyto.2009.07.102 |
0.425 |
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| 2008 |
Beutler B, Hoffmann J. What infections actually are Journal of Innate Immunity. 1: 2-3. PMID 20391631 DOI: 10.1159/000143226 |
0.335 |
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| 2008 |
Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA, Catz SD. The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic (Copenhagen, Denmark). 9: 2151-64. PMID 18939952 DOI: 10.1111/J.1600-0854.2008.00838.X |
0.444 |
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| 2008 |
Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proceedings of the National Academy of Sciences of the United States of America. 105: 15028-33. PMID 18806225 DOI: 10.1073/Pnas.0806619105 |
0.453 |
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| 2008 |
Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, ... Beutler B, et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 105: 14609-14. PMID 18794526 DOI: 10.1073/Pnas.0807219105 |
0.427 |
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| 2008 |
Beutler B, Moresco EM. The forward genetic dissection of afferent innate immunity. Current Topics in Microbiology and Immunology. 321: 3-26. PMID 18727485 DOI: 10.1007/978-3-540-75203-5_1 |
0.498 |
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| 2008 |
Beutler B. Immunology, phenotype first. Preface. Current Topics in Microbiology and Immunology. 321: v-viii. PMID 18727484 |
0.29 |
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| 2008 |
Chaix J, Tessmer MS, Hoebe K, Fuséri N, Ryffel B, Dalod M, Alexopoulou L, Beutler B, Brossay L, Vivier E, Walzer T. Cutting edge: Priming of NK cells by IL-18. Journal of Immunology (Baltimore, Md. : 1950). 181: 1627-31. PMID 18641298 DOI: 10.4049/Jimmunol.181.3.1627 |
0.366 |
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| 2008 |
Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229(4716):869-871. Classical article. Journal of Immunology (Baltimore, Md. : 1950). 181: 7-9. PMID 18566363 |
0.526 |
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| 2008 |
Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B. The serine protease TMPRSS6 is required to sense iron deficiency. Science (New York, N.Y.). 320: 1088-92. PMID 18451267 DOI: 10.1126/Science.1157121 |
0.493 |
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| 2008 |
Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schütze N, Beutler B, Galanos C. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity Immunobiology. 213: 193-203. PMID 18406367 DOI: 10.1016/J.Imbio.2007.11.008 |
0.498 |
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| 2008 |
Georgel P, Du X, Hoebe K, Beutler B. ENU mutagenesis in mice. Methods in Molecular Biology (Clifton, N.J.). 415: 1-16. PMID 18370145 DOI: 10.1007/978-1-59745-570-1_1 |
0.436 |
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| 2008 |
Hoebe K, Beutler BA. Forward genetic analysis of TLR-signaling pathways: An evaluation Advanced Drug Delivery Reviews. 60: 824-829. PMID 18331766 DOI: 10.1016/J.Addr.2008.02.002 |
0.444 |
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| 2008 |
Xia CH, Liu H, Cheung D, Wang M, Cheng C, Du X, Chang B, Beutler B, Gong X. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Human Molecular Genetics. 17: 1605-12. PMID 18263894 DOI: 10.1093/Hmg/Ddn047 |
0.42 |
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| 2008 |
Beutler B, Moresco EM. Akirins versus infection. Nature Immunology. 9: 7-9. PMID 18087247 DOI: 10.1038/Ni0108-7 |
0.387 |
|
| 2008 |
Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E, Beutler B. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis (Journal of Experimental Medicine (2007) 204, 4, (853-863)) Journal of Experimental Medicine. 205. DOI: 10.1084/Jem.20062447020108C |
0.368 |
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| 2008 |
Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EMY, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 39, (15028-15033) DOI:10.1073/pnas.0806619105) Proceedings of the National Academy of Sciences of the United States of America. 105: 19561. DOI: 10.1073/Pnas.0810917105 |
0.388 |
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| 2008 |
Beutler B. Genetics of Innate Immunity International Journal of Infectious Diseases. 12. DOI: 10.1016/J.Ijid.2008.05.043 |
0.409 |
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| 2008 |
Beutler B. Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology - Preface Current Topics in Microbiology and Immunology. 321: v-viii. DOI: 10.1007/978-3-540-75203-5 |
0.469 |
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| 2007 |
Koehn J, Huesken D, Jaritz M, Rot A, Zurini M, Dwertmann A, Beutler BA, Korthäuer U. Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response Human Immunology. 68: 871-878. PMID 18082565 DOI: 10.1016/J.Humimm.2007.07.007 |
0.454 |
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| 2007 |
Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, Eleftherianos I, Imler JL, Beutler B. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nature Genetics. 39: 1453-60. PMID 18026101 DOI: 10.1038/Ng.2007.25 |
0.471 |
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| 2007 |
Beutler B. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunological Reviews. 220: 113-128. PMID 17979843 DOI: 10.1111/J.1600-065X.2007.00577.X |
0.477 |
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| 2007 |
Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, Akira S. Genetic analysis of resistance to viral infection Nature Reviews Immunology. 7: 753-766. PMID 17893693 DOI: 10.1038/Nri2174 |
0.399 |
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| 2007 |
Han JH, Akira S, Calame K, Beutler B, Selsing E, Imanishi-Kari T. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity. 27: 64-75. PMID 17658280 DOI: 10.1016/J.Immuni.2007.05.018 |
0.428 |
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| 2007 |
Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, Kang YJ, Jiang Z, Du X, Cook R, Das SC, Pattnaik AK, Beutler B, Han J. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 27: 123-34. PMID 17613256 DOI: 10.1016/J.Immuni.2007.05.014 |
0.365 |
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| 2007 |
Beutler B, Du X, Xia Y. Precis on forward genetics in mice. Nature Immunology. 8: 659-664. PMID 17579639 DOI: 10.1038/Ni0707-659 |
0.407 |
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| 2007 |
Kim SO, Ha SD, Lee S, Stanton S, Beutler B, Han J. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. Biotechniques. 42: 493-501. PMID 17489237 DOI: 10.2144/000112390 |
0.421 |
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| 2007 |
Baccala R, Hoebe K, Kono DH, Beutler BA, Theofilopoulos AN. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nature Medicine. 13: 543-551. PMID 17479100 DOI: 10.1038/Nm1590 |
0.449 |
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| 2007 |
Togbe D, Schofield L, Grau GE, Schnyder B, Boissay V, Charron S, Rose S, Beutler B, Quesniaux VF, Ryffel B. Murine cerebral malaria development is independent of toll-like receptor signaling. The American Journal of Pathology. 170: 1640-8. PMID 17456769 DOI: 10.2353/Ajpath.2007.060889 |
0.49 |
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| 2007 |
Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling Journal of Cell Biology. 177: 265-275. PMID 17452530 DOI: 10.1083/Jcb.200612056 |
0.463 |
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| 2007 |
Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E, Beutler B. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis Journal of Experimental Medicine. 204: 853-863. PMID 17420270 DOI: 10.1084/Jem.20062447 |
0.472 |
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| 2007 |
Taylor KR, Yamasaki K, Radek KA, Di Nardo A, Goodarzi H, Golenbock D, Beutler B, Gallo RL. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. The Journal of Biological Chemistry. 282: 18265-75. PMID 17400552 DOI: 10.1074/Jbc.M606352200 |
0.458 |
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| 2007 |
Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, Hoebe K, Bahram S, Oldstone MB, Beutler B. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology. 362: 304-13. PMID 17292937 DOI: 10.1016/J.Virol.2006.12.032 |
0.484 |
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| 2007 |
Munafó DB, Johnson JL, Ellis BA, Rutschmann S, Beutler B, Catz SD. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. The Biochemical Journal. 402: 229-39. PMID 17090228 DOI: 10.1042/Bj20060950 |
0.426 |
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| 2007 |
Beutler E, Lee P, Gelbart T, Du X, Beutler B. The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron. Blood. 110: 3-3. DOI: 10.1182/Blood.V110.11.3.3 |
0.523 |
|
| 2006 |
Xia CH, Liu H, Wang M, Cheung D, Park A, Yang Y, Du X, Chang B, Beutler B, Gong X. Characterization of mouse mutants with abnormal RPE cells. Advances in Experimental Medicine and Biology. 572: 95-100. PMID 17249561 DOI: 10.1007/0-387-32442-9_15 |
0.35 |
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| 2006 |
Gavin AL, Hoebe K, Duong B, Ota T, Martin C, Beutler B, Nemazee D. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (New York, N.Y.). 314: 1936-8. PMID 17185603 DOI: 10.1126/Science.1135299 |
0.452 |
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| 2006 |
Meehan TP, Tabeta K, Du X, Woodward LS, Firozi K, Beutler B, Justice MJ. Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 17: 1162-71. PMID 17143585 DOI: 10.1007/S00335-006-0073-Z |
0.444 |
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| 2006 |
Hoebe K, Jiang Z, Georgel P, Tabeta K, Janssen E, Du X, Beutler B. TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. Current Pharmaceutical Design. 12: 4123-4134. PMID 17100615 DOI: 10.2174/138161206778743466 |
0.449 |
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| 2006 |
Beutler B. Fighting malaria : Mosquitoes know how Immunity. 25: 530-531. PMID 17046681 DOI: 10.1016/J.Immuni.2006.10.001 |
0.37 |
|
| 2006 |
Togbe D, Aurore G, Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Vasseur V, Akira S, Hoebe K, Beutler B, Ryffel B, Couillin I. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Laboratory Investigation; a Journal of Technical Methods and Pathology. 86: 1126-35. PMID 16983331 DOI: 10.1038/Labinvest.3700473 |
0.433 |
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| 2006 |
Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, Alcais A, Picard C, Mahfoufi N, Nicolas N, Lorenzo L, Plancoulaine S, Sénéchal B, Geissmann F, Tabeta K, ... ... Beutler B, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (New York, N.Y.). 314: 308-12. PMID 16973841 DOI: 10.1126/Science.1128346 |
0.427 |
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| 2006 |
Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K, Beutler B. Genetic analysis of innate immunity. Advances in Immunology. 91: 175-226. PMID 16938541 DOI: 10.1016/S0065-2776(06)91005-0 |
0.51 |
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| 2006 |
Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nature Immunology. 7: 978-86. PMID 16921381 DOI: 10.1038/Ni1380 |
0.652 |
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| 2006 |
Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A, Beutler B. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 10961-6. PMID 16832055 DOI: 10.1073/Pnas.0603804103 |
0.448 |
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| 2006 |
Janssen E, Tabeta K, Barnes MJ, Rutschmann S, McBride S, Bahjat KS, Schoenberger SP, Theofilopoulos AN, Beutler B, Hoebe K. Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity. 24: 787-99. PMID 16782034 DOI: 10.1016/J.Immuni.2006.03.024 |
0.465 |
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| 2006 |
Rutschmann S, Hoebe K, Zalevsky J, Du X, Mann N, Dahiyat BI, Steed P, Beutler B. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development. Journal of Immunology (Baltimore, Md. : 1950). 176: 7525-32. PMID 16751399 DOI: 10.4049/Jimmunol.176.12.7525 |
0.485 |
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| 2006 |
Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, Diamond MS, Colonna M. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proceedings of the National Academy of Sciences of the United States of America. 103: 8459-64. PMID 16714379 DOI: 10.1073/Pnas.0603082103 |
0.466 |
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| 2006 |
Nemazee D, Gavin A, Hoebe K, Beutler B. Immunology: Toll-like receptors and antibody responses. Nature. 441: E4; discussion E4. PMID 16710369 DOI: 10.1038/Nature04875 |
0.481 |
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| 2006 |
Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, Beutler B. Analysis of the MCMV resistome by ENU mutagenesis. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 17: 398-406. PMID 16688530 DOI: 10.1007/S00335-005-0164-2 |
0.457 |
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| 2006 |
Hoebe K, Beutler B. TRAF3: a new component of the TLR-signaling apparatus Trends in Molecular Medicine. 12: 187-189. PMID 16621716 DOI: 10.1016/J.Molmed.2006.03.008 |
0.493 |
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| 2006 |
Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Beutler B, Lo WK, Gong X. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development (Cambridge, England). 133: 2033-40. PMID 16611690 DOI: 10.1242/Dev.02361 |
0.361 |
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| 2006 |
Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annual Review of Immunology. 24: 353-89. PMID 16551253 DOI: 10.1146/Annurev.Immunol.24.021605.090552 |
0.495 |
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| 2006 |
Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Beutler B, Galanos C, Freudenberg MA. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. European Journal of Immunology. 36: 701-11. PMID 16506285 DOI: 10.1002/Eji.200535593 |
0.462 |
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| 2006 |
Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, Mudd S, Mann N, Sovath S, Goode J, Shamel L, Herskovits AA, Portnoy DA, Cooke M, Tarantino LM, ... ... Beutler B, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nature Immunology. 7: 156-64. PMID 16415873 DOI: 10.1038/Ni1297 |
0.428 |
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| 2006 |
Fischer H, Yamamoto M, Akira S, Beutler B, Svanborg C. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. European Journal of Immunology. 36: 267-77. PMID 16385628 DOI: 10.1002/Eji.200535149 |
0.502 |
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| 2006 |
Mattner J, DeBord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, et al. Correction: Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature. 439: 502-502. DOI: 10.1038/Nature04475 |
0.728 |
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| 2005 |
Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Briefings in Functional Genomics & Proteomics. 4: 203-13. PMID 16420746 DOI: 10.1093/Bfgp/4.3.203 |
0.452 |
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| 2005 |
Du X, Tabeta K, Mann N, Crozat K, Mudd S, Beutler B. An essential role for Rxrα in the development of Th2 responses European Journal of Immunology. 35: 3414-3423. PMID 16259011 DOI: 10.1002/Eji.200535366 |
0.464 |
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| 2005 |
Wieland CW, Florquin S, Maris NA, Hoebe K, Beutler B, Takeda K, Akira S, Poll Tvd. The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. Journal of Immunology. 175: 6042-6049. PMID 16237099 DOI: 10.4049/Jimmunol.175.9.6042 |
0.497 |
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| 2005 |
Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infection and Immunity. 73: 4512-21. PMID 16040962 DOI: 10.1128/Iai.73.8.4512-4521.2005 |
0.494 |
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| 2005 |
Kim KI, Malakhova OA, Hoebe K, Yan M, Beutler BA, Zhang DE. Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling Journal of Immunology. 175: 847-854. PMID 16002682 DOI: 10.4049/Jimmunol.175.2.847 |
0.492 |
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| 2005 |
Beutler BA. The Toll-like receptors: analysis by forward genetic methods. Immunogenetics. 57: 385-392. PMID 16001129 DOI: 10.1007/S00251-005-0011-3 |
0.512 |
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| 2005 |
Beutler B, Casanova JL. New frontiers in immunology Embo Reports. 6: 620-623. PMID 15976818 DOI: 10.1038/Sj.Embor.7400457 |
0.458 |
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| 2005 |
Beutler B, Hoebe K, Georgel P, Tabeta K, Du X. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. Advances in Experimental Medicine and Biology. 560: 29-39. PMID 15934170 DOI: 10.1007/0-387-24180-9_4 |
0.51 |
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| 2005 |
Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. CD14 is required for MyD88-independent LPS signaling. Nature Immunology. 6: 565-70. PMID 15895089 DOI: 10.1038/Ni1207 |
0.483 |
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| 2005 |
Zhou Z, Hoebe K, Du X, Jiang Z, Shamel L, Beutler BA. Antagonism between MyD88‐ and TRIF‐dependent signals in B7RP‐1 up‐regulation European Journal of Immunology. 35: 1918-1927. PMID 15884053 DOI: 10.1002/Eji.200525971 |
0.479 |
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| 2005 |
Liu H, Du X, Wang M, Huang Q, Ding L, McDonald HW, Yates JR, Beutler B, Horwitz J, Gong X. Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. The Journal of Biological Chemistry. 280: 25071-8. PMID 15878859 DOI: 10.1074/Jbc.M502490200 |
0.401 |
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| 2005 |
Hoebe K, Beutler B. Unraveling innate immunity using large scale N‐ethyl‐N‐nitrosourea mutagenesis Tissue Antigens. 65: 395-401. PMID 15853894 DOI: 10.1111/J.1399-0039.2005.00369.X |
0.453 |
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| 2005 |
Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 434: 525-9. PMID 15791258 DOI: 10.1038/Nature03408 |
0.763 |
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| 2005 |
Theofilopoulos AN, Baccala R, Beutler BA, Kono DH. TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY Annual Review of Immunology. 23: 307-336. PMID 15771573 DOI: 10.1146/Annurev.Immunol.23.021704.115843 |
0.432 |
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| 2005 |
Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 2487-9. PMID 15699327 DOI: 10.1073/Pnas.0409831102 |
0.4 |
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| 2005 |
Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zähringer U, Beutler B. CD36 is a sensor of diacylglycerides. Nature. 433: 523-7. PMID 15690042 DOI: 10.1038/Nature03253 |
0.453 |
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| 2005 |
Beutler B, Crozat K, Koziol JA, Georgel P. Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model. Current Opinion in Immunology. 17: 36-43. PMID 15653308 DOI: 10.1016/J.Coi.2004.11.004 |
0.468 |
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| 2005 |
Beutler B, Cerami A. Cachectin--Tumour necrosis factor: a cytokine that mediates injury initiated by invasive parasites. Parasitology Today (Personal Ed.). 3: 345-6. PMID 15462882 DOI: 10.1016/0169-4758(87)90119-0 |
0.593 |
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| 2004 |
Beutler B. Toll-like receptors and their place in immunology Nature. 4: 498. PMID 18293536 DOI: 10.1038/Nri1401 |
0.401 |
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| 2004 |
Beutler B, Hoebe K, Georgel P, Tabeta K, Du X. Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses. Microbes and Infection / Institut Pasteur. 6: 1374-81. PMID 15596123 DOI: 10.1016/J.Micinf.2004.08.017 |
0.495 |
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| 2004 |
Hoebe K, Janssen E, Beutler B. The interface between innate and adaptive immunity. Nature Immunology. 5: 971-974. PMID 15454919 DOI: 10.1038/Ni1004-971 |
0.411 |
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| 2004 |
Anfossi N, Robbins SH, Ugolini S, Georgel P, Hoebe K, Bouneaud C, Ronet C, Kaser A, DiCioccio CB, Tomasello E, Blumberg RS, Beutler B, Reiner SL, Alexopoulou L, Lantz O, et al. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. Journal of Immunology (Baltimore, Md. : 1950). 173: 3773-82. PMID 15356124 DOI: 10.4049/Jimmunol.173.6.3773 |
0.388 |
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| 2004 |
Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis Proceedings of the National Academy of Sciences of the United States of America. 101: 13560-13565. PMID 15345741 DOI: 10.1073/Pnas.0402760101 |
0.399 |
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| 2004 |
Beutler BA, Hoebe K, Shamel L. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. Comptes Rendus Biologies. 327: 571-580. PMID 15330256 DOI: 10.1016/J.Crvi.2004.03.008 |
0.468 |
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| 2004 |
Beutler B. SHIP, TGF-β, and Endotoxin Tolerance Immunity. 21: 134-135. PMID 15308094 DOI: 10.1016/J.Immuni.2004.07.014 |
0.455 |
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| 2004 |
Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling Nature. 430: 257-263. PMID 15241424 DOI: 10.1038/Nature02761 |
0.477 |
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| 2004 |
Rietschel ET, Rietschel M, Beutler B. How the mighty have fallen: fatal infectious diseases of divine composers. Infectious Disease Clinics of North America. 18: 311-339. PMID 15145383 DOI: 10.1016/J.Idc.2004.02.002 |
0.34 |
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| 2004 |
Crozat K, Beutler B. TLR7: A new sensor of viral infection Proceedings of the National Academy of Sciences of the United States of America. 101: 6835-6836. PMID 15123819 DOI: 10.1073/Pnas.0401347101 |
0.483 |
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| 2004 |
Hoebe K, Beutler BA. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. Journal of Endotoxin Research. 10: 130-136. PMID 15120005 DOI: 10.1179/096805104225004031 |
0.498 |
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| 2004 |
Du X, Tabeta K, Hoebe K, Liu H, Mann N, Mudd S, Crozat K, Sovath S, Gong X, Beutler B. Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics. 166: 331-40. PMID 15020428 DOI: 10.1534/Genetics.166.1.331 |
0.414 |
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| 2004 |
Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J, Alexopoulou L, Flavell RA, Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America. 101: 3516-21. PMID 14993594 DOI: 10.1073/Pnas.0400525101 |
0.524 |
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| 2004 |
Weighardt H, Jusek G, Mages J, Lang R, Hoebe K, Beutler B, Holzmann B. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. European Journal of Immunology. 34: 558-64. PMID 14768061 DOI: 10.1002/Eji.200324714 |
0.496 |
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| 2004 |
Beutler BA. Innate immunity: an overview. Molecular Immunology. 40: 845-859. PMID 14698223 DOI: 10.1016/J.Molimm.2003.10.005 |
0.42 |
|
| 2004 |
Hoebe K, Tabeta K, Georgel P, Du X, Mudd S, Sovath S, Shamel L, Hartung T, Zähringer U, Beutler B. The nonsense allele oblivious reveals a sensor of di-acylglycerides acting in conjunction with TLR2 and TLR6 Arthritis Research & Therapy. 6: 13-13. DOI: 10.1186/Ar1347 |
0.492 |
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| 2004 |
Jiang Z, Li C, Shamel L, Olson A, Beutler B. Pococurante (Poc): An ENU-Induced Missense Mutation of MyD88 with Selective Effects on TLR Signal Transduction. Blood. 104: 649-649. DOI: 10.1182/Blood.V104.11.649.649 |
0.5 |
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| 2004 |
Du X, Bigby T, Tabeta K, Janssen E, Crozat K, Navjiwan M, Beutler B. Pinkie , the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRa in Th2 Development. Blood. 104: 313-313. DOI: 10.1182/Blood.V104.11.313.313 |
0.463 |
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| 2003 |
Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J, Beutler B. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature Immunology. 4: 1223-9. PMID 14625548 DOI: 10.1038/Ni1010 |
0.483 |
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| 2003 |
Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. The Journal of Experimental Medicine. 198: 1563-72. PMID 14623910 DOI: 10.1084/Jem.20031220 |
0.498 |
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| 2003 |
Beutler B, Hoebe K, Du X, Janssen E, Georgel P, Tabeta K. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses. Scandinavian Journal of Infectious Diseases. 35: 563-7. PMID 14620135 DOI: 10.1080/00365540310016295 |
0.52 |
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| 2003 |
Beutler B, Hoebe K, Du X, Ulevitch RJ. How we detect microbes and respond to them: the Toll-like receptors and their transducers. Journal of Leukocyte Biology. 74: 479-485. PMID 12960260 DOI: 10.1189/Jlb.0203082 |
0.506 |
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| 2003 |
Hoebe K, Du X, Goode J, Mann N, Beutler B. Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. Journal of Endotoxin Research. 9: 250-5. PMID 12935356 DOI: 10.1179/096805103225001459 |
0.491 |
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| 2003 |
Beutler B. Not "molecular patterns" but molecules. Immunity. 19: 155-156. PMID 12932347 DOI: 10.1016/S1074-7613(03)00212-7 |
0.412 |
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| 2003 |
Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature. 424: 743-8. PMID 12872135 DOI: 10.1038/Nature01889 |
0.519 |
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| 2003 |
Beutler BA, Du X, Hoebe K. From Phenomenon to Phenotype and from Phenotype to Gene: Forward Genetics and the Problem of Sepsis The Journal of Infectious Diseases. 187. PMID 12792846 DOI: 10.1086/374757 |
0.388 |
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| 2003 |
Stevenson BJ, Iseli C, Beutler B, Jongeneel CV. Use of transcriptome data to unravel the fine structure of genes involved in sepsis. The Journal of Infectious Diseases. 187: S308-14. PMID 12792844 DOI: 10.1086/374755 |
0.398 |
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| 2003 |
Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M, Beutler B. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 100: 6075-80. PMID 12730365 DOI: 10.1073/Pnas.1031605100 |
0.469 |
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| 2003 |
Beutler BA, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin Nature Reviews Immunology. 3: 169-176. PMID 12563300 DOI: 10.1038/Nri1004 |
0.422 |
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| 2003 |
Beutler BA. Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors. Annual Review of Pharmacology and Toxicology. 43: 609-628. PMID 12540749 DOI: 10.1146/Annurev.Pharmtox.43.100901.135729 |
0.445 |
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| 2003 |
Kim SO, Jing Q, Hoebe K, Beutler B, Duesbery NS, Han J. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. The Journal of Biological Chemistry. 278: 7413-21. PMID 12488448 DOI: 10.1074/Jbc.M209279200 |
0.443 |
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| 2002 |
Beutler B. Science review: key inflammatory and stress pathways in critical illness - the central role of the Toll-like receptors. Critical Care. 7: 39-46. PMID 12617739 DOI: 10.1186/Cc1828 |
0.415 |
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| 2002 |
Beutler BA. LPS in microbial pathogenesis: promise and fulfilment. Journal of Endotoxin Research. 8: 329-335. PMID 12537691 DOI: 10.1179/096805102125000650 |
0.461 |
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| 2002 |
Beutler BA. Innate immune sensing of microbial infection: the mechanism and the therapeutic challenge. Wiener Medizinische Wochenschrift. 152: 547-551. PMID 12506676 DOI: 10.1046/J.1563-258X.2002.02097.X |
0.469 |
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| 2002 |
Beutler B, Beutler E. Toll-like receptor 4 polymorphisms and atherogenesis. The New England Journal of Medicine. 347: 1978-80; author repl. PMID 12479194 |
0.444 |
|
| 2002 |
Beutler B. TLR4 as the Mammalian Endotoxin Sensor Current Topics in Microbiology and Immunology. 270: 109-120. PMID 12467247 DOI: 10.1007/978-3-642-59430-4_7 |
0.48 |
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| 2002 |
Beutler B, Rehli M. Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. Current Topics in Microbiology and Immunology. 270: 1-21. PMID 12467241 DOI: 10.1007/978-3-642-59430-4_1 |
0.465 |
|
| 2002 |
Beutler B. Endotoxin antagonism: conceptual basis and therapeutic potential. Expert Opinion On Therapeutic Targets. 6: 147-158. PMID 12223077 DOI: 10.1517/14728222.6.2.147 |
0.421 |
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| 2002 |
Beutler B. Toll-like receptors: how they work and what they do. Current Opinion in Hematology. 9: 2-10. PMID 11753071 DOI: 10.1097/00062752-200201000-00002 |
0.453 |
|
| 2002 |
Beutler B. Review paper: LPS in microbial pathogenesis: promise and fulfilment: Journal of Endotoxin Research. 8: 329-335. DOI: 10.1177/09680519020080050601 |
0.459 |
|
| 2001 |
Beutler B, Ulevitch RJ. Genetic Analysis of Host Responses in Sepsis. Current Infectious Disease Reports. 3: 419-426. PMID 24395480 DOI: 10.1007/S11908-007-1009-9 |
0.443 |
|
| 2001 |
Beutler BA. Sepsis begins at the interface of pathogen and host. Biochemical Society Transactions. 29: 853-859. PMID 11709087 DOI: 10.1042/0300-5127:0290853 |
0.464 |
|
| 2001 |
Beutler B. Autoimmunity and Apoptosis: The Crohn's Connection Immunity. 15: 5-14. PMID 11485733 DOI: 10.1016/S1074-7613(01)00176-5 |
0.32 |
|
| 2001 |
Redl HR, Aderem A, Beutler BA, Calandra T, Mira JP, Ulevitch R. Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components. Critical Care Medicine. 29: S19-20. PMID 11445729 DOI: 10.1097/00003246-200107001-00010 |
0.406 |
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| 2001 |
Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Critical Care Medicine. 29: S2-6; discussion S6-. PMID 11445725 DOI: 10.1097/00003246-200107001-00002 |
0.454 |
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| 2001 |
Kimbrell DA, Beutler B. The evolution and genetics of innate immunity. Nature Reviews. Genetics. 2: 256-67. PMID 11283698 DOI: 10.1038/35066006 |
0.444 |
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| 2001 |
Beutler B, Poltorak A. Toll we meet again.... Nature Immunology. 2: 9-10. PMID 11135568 DOI: 10.1038/83222 |
0.446 |
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| 2001 |
Beutler B, Du X, Poltorak A. Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies Journal of Endotoxin Research. 7: 277-280. DOI: 10.1179/096805101101532846 |
0.454 |
|
| 2001 |
Beutler B. How the innate immune system senses infection Biochemical Society Transactions. 29. DOI: 10.1042/Bst029A101B |
0.415 |
|
| 2000 |
Smirnova I, Poltorak A, Chan EK, McBride C, Beutler B. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biology. 1: RESEARCH002. PMID 11104518 DOI: 10.1186/Gb-2000-1-1-Research002 |
0.494 |
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| 2000 |
Poltorak A, Smirnova I, Clisch R, Beutler B. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. Journal of Endotoxin Research. 6: 51-6. PMID 11061032 DOI: 10.1177/09680519000060010701 |
0.491 |
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| 2000 |
Rehli M, Poltorak A, Schwarzfischer L, Krause SW, Andreesen R, Beutler B. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. The Journal of Biological Chemistry. 275: 9773-81. PMID 10734131 DOI: 10.1074/Jbc.275.13.9773 |
0.502 |
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| 2000 |
Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler BA. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation Proceedings of the National Academy of Sciences of the United States of America. 97: 2163-2167. PMID 10681462 DOI: 10.1073/Pnas.040565397 |
0.455 |
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| 2000 |
Beutler B. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity. Current Opinion in Microbiology. 3: 23-8. PMID 10679425 DOI: 10.1016/S1369-5274(99)00046-6 |
0.487 |
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| 2000 |
Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Current Opinion in Immunology. 12: 20-6. PMID 10679411 DOI: 10.1016/S0952-7915(99)00046-1 |
0.462 |
|
| 2000 |
Du X, Poltorak A, Silva M, Beutler B. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells, Molecules & Diseases. 25: 328-38. PMID 10660480 DOI: 10.1006/Bcmd.1999.0262 |
0.476 |
|
| 2000 |
Beutler B, Poltorak A. The search for Lps: 1993–1998 Journal of Endotoxin Research. 6: 269-293. DOI: 10.1179/096805100101532153 |
0.385 |
|
| 2000 |
Beutler B, Poltorak A. The search for Lps Journal of Endotoxin Research. 6: 301-302. DOI: 10.1177/09680519000060040401 |
0.388 |
|
| 2000 |
Beutler B, Poltorak A. Review: The search for Lps: 1993—1998 Journal of Endotoxin Research. 6: 269-293. DOI: 10.1177/09680519000060040201 |
0.389 |
|
| 2000 |
Nattermann J, Du X, Wei Y, Shevchenko D, Beutler B. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4. Journal of Endotoxin Research. 6: 257-264. DOI: 10.1177/09680519000060030701 |
0.497 |
|
| 2000 |
Du X, Poltorak A, Silva M, Beutler B. Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor Blood Cells, Molecules, and Diseases. 26: 9. DOI: 10.1006/Bcmd.2000.0278 |
0.475 |
|
| 1999 |
Beutler BA. The role of tumor necrosis factor in health and disease. The Journal of Rheumatology. Supplement. 57: 16-21. PMID 10328138 |
0.313 |
|
| 1999 |
Brown GR, Lindberg G, Meddings J, Silva M, Beutler B, Thiele D. Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology. 116: 593-601. PMID 10029618 DOI: 10.1016/S0016-5085(99)70181-2 |
0.441 |
|
| 1999 |
Poltorak A, Smirnova I, He X, Liu M, Huffel CV, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, ... ... Beutler B, et al. Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region Blood Cells, Molecules, and Diseases. 25: 78. DOI: 10.1006/Bcmd.1999.0230 |
0.376 |
|
| 1999 |
Koziol JA, Beutler BA. Estimation of Physical Distance in the Genome through Probabilistic Analysis of Marker Density and Yeast Artificial Chromosome (YAC) Size Biometrical Journal. 41: 251-257. DOI: 10.1002/(Sici)1521-4036(199905)41:2<251::Aid-Bimj251>3.0.Co;2-1 |
0.313 |
|
| 1998 |
Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, ... ... Beutler B, et al. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells, Molecules & Diseases. 24: 340-55. PMID 10087992 DOI: 10.1006/Bcmd.1998.0201 |
0.423 |
|
| 1998 |
Brown GR, Silva MD, Thompson PA, Beutler B. Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD-->NOD-scid adoptive T cell transfer. Diabetologia. 41: 1502-10. PMID 9867218 DOI: 10.1007/S001250051097 |
0.413 |
|
| 1998 |
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene Science. 282: 2085-2088. PMID 9851930 DOI: 10.1126/Science.282.5396.2085 |
0.486 |
|
| 1998 |
Beutler B, Bazzoni F. TNF, apoptosis and autoimmunity: a common thread? Blood Cells, Molecules & Diseases. 24: 216-30. PMID 9645922 DOI: 10.1006/Bcmd.1998.0187 |
0.438 |
|
| 1997 |
Brown GR, Thiele DL, Silva M, Beutler B. Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium. Gastroenterology. 112: 1586-94. PMID 9136837 DOI: 10.1016/S0016-5085(97)70040-4 |
0.388 |
|
| 1996 |
Beutler B, Kruys V. Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. Journal of Cardiovascular Pharmacology. S1-8. PMID 8699845 DOI: 10.1097/00005344-199500252-00002 |
0.479 |
|
| 1996 |
Beutler B, Munford RS. Tumor necrosis factor and the Jarisch-Herxheimer reaction. The New England Journal of Medicine. 335: 347-348. PMID 8663859 DOI: 10.1056/Nejm199608013350512 |
0.365 |
|
| 1996 |
Bazzoni F, Beutler BA. The Tumor Necrosis Factor Ligand and Receptor Families The New England Journal of Medicine. 334: 1717-1725. PMID 8637518 DOI: 10.1056/Nejm199606273342607 |
0.437 |
|
| 1995 |
Kolls JK, Lei D, Nelson S, Summer WR, Greenberg S, Beutler B. Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense. The Journal of Infectious Diseases. 171: 570-5. PMID 7876603 DOI: 10.1093/Infdis/171.3.570 |
0.484 |
|
| 1995 |
Kossodo SD, Cruz PD, Dougherty I, Thompson P, Silva-Valdez M, Beutler B. Expression of the Tumor Necrosis Factor Gene by Dermal Fibroblasts in Response to Ultraviolet Irradiation or Lipopolysaccharide Journal of Investigative Dermatology. 104: 318-322. PMID 7860994 DOI: 10.1111/1523-1747.Ep12665361 |
0.432 |
|
| 1995 |
Beutler B. Summary of the 5th International Congress on TNF and related cytokines: scientific advances and their medical applications. Journal of Leukocyte Biology. 57: 11-2. PMID 7829962 DOI: 10.1002/Jlb.57.1.11 |
0.423 |
|
| 1995 |
Bazzoni F, Alejos E, Beutler B. Chimeric tumor necrosis factor receptors with constitutive signaling activity Proceedings of the National Academy of Sciences of the United States of America. 92: 5376-5380. PMID 7777515 DOI: 10.1073/Pnas.92.12.5376 |
0.442 |
|
| 1995 |
Beutler B. Interleukins Etc.. (Book Reviews: Guidebook to Cytokines and Their Receptors) Science. 270: 1693-1694. DOI: 10.1126/Science.270.5242.1693 |
0.391 |
|
| 1995 |
Beutler B. Chapter 25. Programmed Cell Death Mediated by Members of the TNF Receptor Family Annual Reports in Medicinal Chemistry. 30: 239-245. DOI: 10.1016/S0065-7743(08)60938-0 |
0.465 |
|
| 1994 |
Bazzoni F, Kruys V, Shakhov A, Jongeneel C, Beutler B. Analysis of tumor necrosis factor promoter responses to ultraviolet light Journal of Clinical Investigation. 93: 56-62. PMID 8282822 DOI: 10.1172/Jci116984 |
0.471 |
|
| 1994 |
Kolls J, Peppel K, Silva M, Beutler B. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 91: 215-9. PMID 8278368 DOI: 10.1073/Pnas.91.1.215 |
0.442 |
|
| 1994 |
Beutler B, van Huffel C. Unraveling function in the TNF ligand and receptor families. Science (New York, N.Y.). 264: 667-8. PMID 8171316 DOI: 10.1126/Science.8171316 |
0.379 |
|
| 1994 |
Poltorak A, Peppel K, Beutler B. Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations. Journal of Immunological Methods. 169: 93-99. PMID 8133076 DOI: 10.1016/0022-1759(94)90128-7 |
0.405 |
|
| 1994 |
Beutler B, Van Huffel C. An evolutionary and functional approach to the TNF receptor/ligand family. Annals of the New York Academy of Sciences. 730: 118-33. PMID 8080166 DOI: 10.1111/J.1749-6632.1994.Tb44244.X |
0.377 |
|
| 1994 |
Geppert TD, Whitehurst CE, Thompson P, Beutler B. Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway Molecular Medicine. 1: 93-103. DOI: 10.1007/Bf03403535 |
0.458 |
|
| 1993 |
Kruys V, Thompson P, Beutler B. Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway. Journal of Experimental Medicine. 177: 1383-1390. PMID 8478613 DOI: 10.1084/Jem.177.5.1383 |
0.451 |
|
| 1993 |
Harel Y, Silva M, Giroir B, Weinberg A, Cleary TB, Beutler BA. A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome. Journal of Clinical Investigation. 92: 2110-2116. PMID 8227326 DOI: 10.1172/Jci116811 |
0.444 |
|
| 1993 |
Beutler B, Brown T. Polymorphism of the mouse TNF-alpha locus: sequence studies of the 3'-untranslated region and first intron. Gene. 129: 279-83. PMID 8100792 DOI: 10.1016/0378-1119(93)90280-G |
0.407 |
|
| 1993 |
BEUTLER B, GRAU GE. Tumor necrosis factor in the pathogenesis of infectious diseases Critical Care Medicine. 21: S436. DOI: 10.1097/00003246-199310001-00003 |
0.462 |
|
| 1993 |
Beutler B. Cytokines and Cancer Cachexia Hospital Practice. 28: 45-52. DOI: 10.1080/21548331.1993.11442777 |
0.397 |
|
| 1992 |
Giroir BP, Brown T, Beutler B. Constitutive synthesis of tumor necrosis factor in the thymus. Proceedings of the National Academy of Sciences of the United States of America. 89: 4864-4868. PMID 1594585 DOI: 10.1073/Pnas.89.11.4864 |
0.467 |
|
| 1992 |
Giroir BP, Johnson JH, Brown T, Allen GL, Beutler BA. The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia. Journal of Clinical Investigation. 90: 693-698. PMID 1522226 DOI: 10.1172/Jci115939 |
0.427 |
|
| 1992 |
Beutler B. Application of Transcriptional and Posttranscriptional Reporter Constructs to the Analysis of Tumor Necrosis Factor Gene Regulation The American Journal of the Medical Sciences. 303: 129-133. DOI: 10.1097/00000441-199202000-00015 |
0.366 |
|
| 1991 |
Beutler B, Brown T. A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines. The Journal of Clinical Investigation. 87: 1336-44. PMID 2010547 DOI: 10.1172/Jci115137 |
0.475 |
|
| 1991 |
Kutteh WH, Rainey WE, Beutler B, Carr BR. Tumor necrosis factor-α and interleukin-1β production by human fetal Kupffer cells American Journal of Obstetrics and Gynecology. 165: 112-120. PMID 1713018 DOI: 10.1016/0002-9378(91)90237-L |
0.417 |
|
| 1991 |
Beutler B. TNF in pathophysiology: biosynthetic regulation. The Journal of Investigative Dermatology. 95: 81S-84S. PMID 1701813 DOI: 10.1111/1523-1747.Ep12874797 |
0.392 |
|
| 1991 |
Young LS, Proctor RA, Beutler B, McCabe WR, Sheagren JN. University of California/Davis Interdepartmental Conference on gram-negative septicemia. Clinical Infectious Diseases. 13: 666-687. PMID 1681579 DOI: 10.1093/Clinids/13.4.666 |
0.405 |
|
| 1991 |
Peppel K, Crawford D, Beutler B. A Tumor Necrosis Factor (TNF) receptor-IgG Heavy Chain Chimeric Protein as a Bivalent Antagonist of TNF Activity Journal of Experimental Medicine. 174: 1483-1489. PMID 1660525 DOI: 10.1084/Jem.174.6.1483 |
0.448 |
|
| 1990 |
Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. Journal of Experimental Medicine. 172: 391-394. PMID 2358784 DOI: 10.1084/Jem.172.1.391 |
0.428 |
|
| 1990 |
Sáez-Llorens X, Mustafa MM, Ramilo O, Fink C, Beutler B, Nelson JD. Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis. American Journal of Diseases of Children (1960). 144: 353-6. PMID 2305745 DOI: 10.1001/Archpedi.1990.02150270103035 |
0.363 |
|
| 1990 |
Ramilo O, Mertsola J, Luby JP, Beutler B, Mustafa MM, Porter J, Sáez-Llorens X, Olsen KD, McCracken GH. Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis American Journal of Diseases of Children. 144: 349-352. PMID 2305744 DOI: 10.1001/Archpedi.1990.02150270099034 |
0.369 |
|
| 1990 |
Han J, Brown T, Beutler B. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. Journal of Experimental Medicine. 171: 465-475. PMID 2303781 DOI: 10.1084/Jem.171.2.465 |
0.422 |
|
| 1990 |
Beutler B. A proinflammatory mediator with potential relevance in aging. Journal of the American Geriatrics Society. 38: 1027-36. PMID 2212439 DOI: 10.1111/J.1532-5415.1990.Tb04429.X |
0.341 |
|
| 1990 |
Beutler B. The tumor necrosis factors: cachectin and lymphotoxin. Hospital Practice (Office Ed.). 25: 45-56. PMID 2105975 DOI: 10.1080/21548331.1990.11703910 |
0.399 |
|
| 1990 |
Zneimer SM, Crawford D, Schneider NR, Beutler B. Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. Genomics. 8: 175-178. PMID 2081593 DOI: 10.1016/0888-7543(90)90242-M |
0.344 |
|
| 1990 |
Beutler B. The explosion of septic shock Current Opinion in Infectious Diseases. 3: 623-627. DOI: 10.1097/00001432-199010000-00008 |
0.306 |
|
| 1989 |
Cerami A, Beutler B. The role of cachectin/TNF in endotoxic shock and cachexia. Immunology Today. 9: 28-31. PMID 3076757 DOI: 10.1016/0167-5699(88)91353-9 |
0.57 |
|
| 1989 |
Beutler B, Cerami A. The history, properties, and biological effects of cachectin. Biochemistry. 27: 7575-82. PMID 3061461 DOI: 10.1021/Bi00420A001 |
0.488 |
|
| 1989 |
Casey ML, Cox SM, Beutler B, Milewich L, MacDonald PC. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. The Journal of Clinical Investigation. 83: 430-6. PMID 2913048 DOI: 10.1172/Jci113901 |
0.417 |
|
| 1989 |
Mustafa MM, Ramilo O, Mertsola J, Risser RC, Beutler B, Hansen EJ, McCracken GH. Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type b meningitis. The Journal of Infectious Diseases. 160: 818-25. PMID 2809257 DOI: 10.1093/Infdis/160.5.818 |
0.407 |
|
| 1989 |
Mustafa MM, Ramilo O, Olsen KD, Franklin PS, Hansen EJ, Beutler B, McCracken GH. Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis Journal of Clinical Investigation. 84: 1253-1259. PMID 2794062 DOI: 10.1172/Jci114292 |
0.421 |
|
| 1989 |
Mustafa MM, Lebel MH, Ramilo O, Olsen KD, Reisch JS, Beutler B, McCracken GH. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis The Journal of Pediatrics. 115: 208-213. PMID 2787856 DOI: 10.1016/S0022-3476(89)80067-8 |
0.353 |
|
| 1989 |
Takayama K, Qureshi N, Beutler B, Kirkland TN. Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide. Infection and Immunity. 57: 1336-8. PMID 2784418 DOI: 10.1128/Iai.57.4.1336-1338.1989 |
0.416 |
|
| 1989 |
Beutler BA. Orchestration of septic shock by cytokines: the role of cachectin (tumor necrosis factor). Progress in Clinical and Biological Research. 286: 219-35. PMID 2648412 |
0.291 |
|
| 1989 |
Crawford D, Hagerty K, Beutler B. Multiple splice forms of ribonuclease-inhibitor mRNA differ in the 5′-untranslated region Gene. 85: 525-531. PMID 2628182 DOI: 10.1016/0378-1119(89)90447-2 |
0.338 |
|
| 1989 |
Rettori V, Milenkovic L, Beutler BA, McCann SM. Hypothalamic action of cachectin to alter pituitary hormone release. Brain Research Bulletin. 23: 471-5. PMID 2611689 DOI: 10.1016/0361-9230(89)90192-5 |
0.358 |
|
| 1989 |
Milenkovic L, Rettori V, Snyder GD, Beutler B, McCann SM. Cachectin alters anterior pituitary hormone release by a direct action in vitro. Proceedings of the National Academy of Sciences of the United States of America. 86: 2418-22. PMID 2564680 DOI: 10.1073/Pnas.86.7.2418 |
0.356 |
|
| 1989 |
Beutler B, Cerami A. The biology of cachectin/TNF--a primary mediator of the host response. Annual Review of Immunology. 7: 625-55. PMID 2540776 DOI: 10.1146/Annurev.Iy.07.040189.003205 |
0.597 |
|
| 1989 |
Pauli U, Beutler BA, Peterhans E. Porcine tumor necrosis factor alpha: cloning with the polymerase chain reaction and determination of the nucleotide sequence. Gene. 81: 185-191. PMID 2478420 DOI: 10.1016/0378-1119(89)90350-8 |
0.379 |
|
| 1989 |
Beutler E, Gelbart T, Han J, Koziol JA, Beutler B. Evolution of the genome and the genetic code: Selection at the dinucleotide level by methylation and polyribonucleotide cleavage Proceedings of the National Academy of Sciences of the United States of America. 86: 192-196. PMID 2463621 DOI: 10.1073/Pnas.86.1.192 |
0.465 |
|
| 1989 |
Beutler BA. Cachectin in tissue injury, shock, and related states. Critical Care Clinics. 5: 353-367. DOI: 10.1016/S0749-0704(18)30441-X |
0.41 |
|
| 1988 |
Beutler B. The presence of cachectin/tumor necrosis factor in human disease states. The American Journal of Medicine. 85: 287-8. PMID 3414725 DOI: 10.1016/0002-9343(88)90575-X |
0.362 |
|
| 1988 |
Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, Kuo GC, Beutler B, Cotran RS, Cerami A. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. The Journal of Experimental Medicine. 167: 1211-27. PMID 3351436 DOI: 10.1084/Jem.167.3.1211 |
0.564 |
|
| 1988 |
Beutler B, Thompson P, Keyes J, Hagerty K, Crawford D. Assay of a ribonuclease that preferentially hydrolyses mRNAs containing cytokine-derived UA-rich instability sequences Biochemical and Biophysical Research Communications. 152: 973-980. PMID 3288201 DOI: 10.1016/S0006-291X(88)80379-6 |
0.368 |
|
| 1988 |
Beutler B, Cerami A. Cachectin, cachexia, and shock. Annual Review of Medicine. 39: 75-83. PMID 3285792 DOI: 10.1146/Annurev.Me.39.020188.000451 |
0.594 |
|
| 1988 |
Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. The Journal of Experimental Medicine. 167: 570-81. PMID 3279154 DOI: 10.1084/Jem.167.2.570 |
0.592 |
|
| 1988 |
Zuckerman SH, Surprenant YM, Carlson DG, Beutler B. Restoration of the lipopolysaccharide-responsive phenotype in C3H/HeJ peritoneal macrophage-P388D1 cell hybrids. Journal of Leukocyte Biology. 43: 133-9. PMID 3257249 DOI: 10.1002/Jlb.43.2.133 |
0.429 |
|
| 1988 |
Beutler B, Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annual Review of Biochemistry. 57: 505-18. PMID 3052281 DOI: 10.1146/Annurev.Bi.57.070188.002445 |
0.537 |
|
| 1988 |
Huber M, Beutler B, Keppler D. Tumor necrosis factor α stimulates leukotriene production in vivo European Journal of Immunology. 18: 2085-2088. PMID 2851448 DOI: 10.1002/Eji.1830181233 |
0.435 |
|
| 1988 |
Beutler B, Cerami A. The common mediator of shock, cachexia, and tumor necrosis. Advances in Immunology. 42: 213-31. PMID 2834923 DOI: 10.1016/S0065-2776(08)60846-9 |
0.576 |
|
| 1988 |
BEUTLER B, CERAMI A. Cachectin (Tumor Necrosis Factor): A Macrophage Hormone Governing Cellular Metabolism and Inflammatory Response Endocrine Reviews. 9: 57-66. DOI: 10.1210/Edrv-9-1-57 |
0.594 |
|
| 1988 |
Beutler B. Tumour necrosis factor and related cytokines (CIBA foundation symposium 131) Immunology Today. 9: 183. DOI: 10.1016/0167-5699(88)91296-0 |
0.377 |
|
| 1987 |
Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. The New England Journal of Medicine. 316: 379-85. PMID 3543677 DOI: 10.1056/Nejm198702123160705 |
0.53 |
|
| 1987 |
Cerami A, Beutler B. Cachectin: the dark side of tumor necrosis factor. Cold Spring Harbor Symposia On Quantitative Biology. 625-9. PMID 3472741 DOI: 10.1101/Sqb.1986.051.01.074 |
0.513 |
|
| 1987 |
Cerami A, Tracey KJ, Lowry SF, Beutler B. Cachectin: a pluripotent hormone released during the host response to invasion. Recent Progress in Hormone Research. 43: 99-112. PMID 3306842 DOI: 10.1016/B978-0-12-571143-2.50009-5 |
0.581 |
|
| 1987 |
Beutler B, Cerami A. Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation. Immunologic Research. 5: 281-93. PMID 3036973 DOI: 10.1007/Bf02935501 |
0.569 |
|
| 1986 |
Tracey KJ, Beutler B, Lowry SF, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fahey TJ, Zentella A, Albert JD. Shock and tissue injury induced by recombinant human cachectin. Science (New York, N.Y.). 234: 470-4. PMID 3764421 DOI: 10.1126/Science.3764421 |
0.429 |
|
| 1986 |
Tracey KJ, Lowry SF, Beutler B, Cerami A, Albert JD, Shires GT. Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential. The Journal of Experimental Medicine. 164: 1368-73. PMID 3760781 DOI: 10.1084/Jem.164.4.1368 |
0.521 |
|
| 1986 |
Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (New York, N.Y.). 232: 977-80. PMID 3754653 DOI: 10.1126/Science.3754653 |
0.597 |
|
| 1986 |
Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA, O'Connor JV. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. The Journal of Experimental Medicine. 163: 1433-50. PMID 3486936 DOI: 10.1084/Jem.163.6.1433 |
0.72 |
|
| 1986 |
Beutler B, Tkacenko V, Milsark I, Krochin N, Cerami A. Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype. The Journal of Experimental Medicine. 164: 1791-6. PMID 3095481 DOI: 10.1084/Jem.164.5.1791 |
0.57 |
|
| 1986 |
Beutler B, Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 320: 584-8. PMID 3010124 DOI: 10.1038/320584A0 |
0.556 |
|
| 1986 |
Dayer JM, Beutler B, Cerami A. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. The Journal of Experimental Medicine. 162: 2163-8. PMID 2999289 DOI: 10.1084/Jem.162.6.2163 |
0.577 |
|
| 1986 |
Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators Proceedings of the National Academy of Sciences of the United States of America. 83: 1670-1674. PMID 2419912 DOI: 10.1073/Pnas.83.6.1670 |
0.541 |
|
| 1985 |
Mahoney JR, Beutler BA, Le Trang N, Vine W, Ikeda Y, Kawakami M, Cerami A. Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells. Journal of Immunology (Baltimore, Md. : 1950). 134: 1673-5. PMID 3968430 |
0.511 |
|
| 1985 |
Cerami A, Ikeda Y, Le Trang N, Hotez PJ, Beutler B. Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). Immunology Letters. 11: 173-7. PMID 3910566 DOI: 10.1016/0165-2478(85)90165-8 |
0.655 |
|
| 1985 |
Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (New York, N.Y.). 229: 869-71. PMID 3895437 DOI: 10.1126/Science.3895437 |
0.589 |
|
| 1985 |
Beutler B, Mahoney J, Le Trang N, Pekala P, Cerami A. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. The Journal of Experimental Medicine. 161: 984-95. PMID 3872925 DOI: 10.1084/Jem.161.5.984 |
0.591 |
|
| 1985 |
Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GM. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia Science. 229: 867-869. PMID 3839597 DOI: 10.1126/Science.3839597 |
0.556 |
|
| 1985 |
Beutler BA, Milsark IW, Cerami A. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. Journal of Immunology (Baltimore, Md. : 1950). 135: 3972-7. PMID 2999236 |
0.516 |
|
| 1985 |
Beutler BA, Cerami A. Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. Journal of Immunology (Baltimore, Md. : 1950). 135: 3969-71. PMID 2999235 |
0.503 |
|
| 1985 |
Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YC, Mathison J, Ulevitch R, Cerami A. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature. 316: 552-4. PMID 2993897 DOI: 10.1038/316552A0 |
0.605 |
|
| 1982 |
Beutler BA, Stefansson K, Arnason BG. A biochemically distinct sub-population of neurons in the human substantia gelatinosa. Study with G-6-PD histochemistry. Journal of the Neurological Sciences. 55: 175-83. PMID 6182274 DOI: 10.1016/0022-510X(82)90099-5 |
0.337 |
|
| 1981 |
Beutler BA, Noronha AB, Poon MM, Arnason BG. The absence of unique kainic acid-like molecules in urine, serum, and CSF from Huntington's disease patients. Journal of the Neurological Sciences. 51: 355-60. PMID 6115893 DOI: 10.1016/0022-510X(81)90113-1 |
0.349 |
|
| 1978 |
Beutler B, Nagai Y, Ohno S, Klein G, Shapiro IM. The HLA-dependent expression of testis- organizing H-Y antigen by human male cells. Cell. 13: 509-13. PMID 77737 DOI: 10.1016/0092-8674(78)90324-0 |
0.478 |
|
| 1975 |
Beutler E, Beutler B, Matsumoto F. Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine. Cellular and Molecular Life Sciences. 31: 769-770. PMID 1140308 DOI: 10.1007/Bf01938453 |
0.449 |
|
| 1974 |
Beutler E, West C, Beutler B. Electrophoretic polymorphism of glutathione peroxidase Annals of Human Genetics. 38: 163-169. PMID 4467780 DOI: 10.1111/J.1469-1809.1974.Tb01947.X |
0.471 |
|
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