| Year |
Citation |
Score |
| 2022 |
Weaver JR, Odanga JJ, Wolf KK, Piekos S, Biven M, Taub M, LaRocca J, Thomas C, Byer-Alcorace A, Chen J, Lee JB, LeCluyse EL. The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system. Toxicology in Vitro : An International Journal Published in Association With Bibra. 86: 105504. PMID 36288780 DOI: 10.1016/j.tiv.2022.105504 |
0.342 |
|
| 2020 |
Ware BR, Brown GE, Soldatow VY, LeCluyse EL, Khetani SR. ERRATUM. Gene Expression. 20: 75-76. PMID 32522329 DOI: 10.3727/105221620X15886997679754 |
0.318 |
|
| 2019 |
Deisenroth C, Soldatow VY, Ford J, Stewart W, Brinkman C, LeCluyse EL, MacMillan DK, Thomas RS. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31808822 DOI: 10.1093/Toxsci/Kfz238 |
0.361 |
|
| 2019 |
McMullen PD, Bhattacharya S, Woods CG, Pendse SN, McBride MT, Soldatow VY, Deisenroth C, LeCluyse EL, Clewell RA, Andersen ME. Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 31628012 DOI: 10.1016/J.Tiv.2019.02.017 |
0.305 |
|
| 2019 |
Ware BR, Brown GE, Soldatow VY, LeCluyse EL, Khetani SR. Long-term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development. Gene Expression. PMID 31340881 DOI: 10.3727/105221619X15638857793317 |
0.307 |
|
| 2019 |
Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31093666 DOI: 10.1093/Toxsci/Kfz112 |
0.385 |
|
| 2018 |
Baker EJ, Beck NA, Berg EL, Clayton-Jeter HD, Chandrasekera PC, Curley JL, Donzanti BA, Ewart LC, Gunther JM, Kenna JG, LeCluyse EL, Liebman MN, Pugh CL, Watkins PB, Sullivan KM. Advancing nonclinical innovation and safety in pharmaceutical testing. Drug Discovery Today. PMID 30468877 DOI: 10.1016/J.Drudis.2018.11.011 |
0.378 |
|
| 2017 |
Mosedale M, Eaddy JS, Trask OJ, Holman NS, Wolf KK, LeCluyse E, Ware BR, Khetani SR, Lu J, Brock WJ, Roth SE, Watkins PB. miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29029277 DOI: 10.1093/Toxsci/Kfx206 |
0.333 |
|
| 2017 |
Tikunov AP, Shim YS, Bhattarai N, Siler SQ, Soldatow V, LeCluyse EL, McDunn JE, Watkins PB, Macdonald JM. Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 28867505 DOI: 10.1016/J.Tiv.2017.08.021 |
0.356 |
|
| 2016 |
Norona LM, Nguyen DG, Gerber DA, Presnell SC, LeCluyse EL. Modeling compound-induced fibrogenesis in vitro using three-dimensional bioprinted human liver tissues. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27605418 DOI: 10.1093/Toxsci/Kfw169 |
0.363 |
|
| 2016 |
Soldatow V, Peffer RC, Trask OJ, Cowie DE, Andersen ME, LeCluyse E, Deisenroth C. Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 27530964 DOI: 10.1016/j.tiv.2016.08.006 |
0.408 |
|
| 2016 |
Holman NS, Mosedale M, Wolf KK, LeCluyse EL, Watkins PB. Sub-toxic alterations in hepatocyte-derived exosomes: an early step in drug-induced liver injury? Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26962055 DOI: 10.1093/Toxsci/Kfw047 |
0.388 |
|
| 2016 |
Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL. Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. Journal of Pharmaceutical Sciences. 105: 950-64. PMID 26869439 DOI: 10.1016/S0022-3549(15)00192-6 |
0.419 |
|
| 2015 |
Lu J, Einhorn S, Venkatarangan L, Miller M, Mann DA, Watkins PB, LeCluyse E. Morphological and Functional Characterization and Assessment of iPSC-derived Hepatocytes for In Vitro Toxicity Testing. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26092927 DOI: 10.1093/toxsci/kfv117 |
0.331 |
|
| 2014 |
Trask OJ, Moore A, LeCluyse EL. A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis. Assay and Drug Development Technologies. 12: 16-27. PMID 24444127 DOI: 10.1089/Adt.2013.525 |
0.391 |
|
| 2014 |
Choi K, Pfund WP, Andersen ME, Thomas RS, Clewell HJ, LeCluyse EL. Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin. Tissue Engineering. Part C, Methods. 20: 641-51. PMID 24294911 DOI: 10.1089/ten.TEC.2013.0562 |
0.308 |
|
| 2014 |
McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions. 209: 14-24. PMID 24269660 DOI: 10.1016/J.Cbi.2013.11.006 |
0.378 |
|
| 2013 |
Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, ... ... LeCluyse EL, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology. 87: 1315-530. PMID 23974980 DOI: 10.1007/S00204-013-1078-5 |
0.401 |
|
| 2013 |
Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Toxicology and Applied Pharmacology. 272: 503-18. PMID 23859880 DOI: 10.1016/J.Taap.2013.06.024 |
0.399 |
|
| 2013 |
Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2Tx20051A |
0.387 |
|
| 2012 |
Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Journal of Pharmaceutical Sciences. 101: 3989-4002. PMID 22806329 DOI: 10.1002/Jps.23262 |
0.692 |
|
| 2012 |
LeCluyse EL, Witek RP, Andersen ME, Powers MJ. Organotypic liver culture models: meeting current challenges in toxicity testing. Critical Reviews in Toxicology. 42: 501-48. PMID 22582993 DOI: 10.3109/10408444.2012.682115 |
0.316 |
|
| 2012 |
Black MB, Budinsky RA, Dombkowski A, Cukovic D, LeCluyse EL, Ferguson SS, Thomas RS, Rowlands JC. Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 199-215. PMID 22298810 DOI: 10.1093/Toxsci/Kfs069 |
0.455 |
|
| 2010 |
Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I. Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicology and Applied Pharmacology. 249: 208-16. PMID 20869979 DOI: 10.1016/J.Taap.2010.09.012 |
0.344 |
|
| 2010 |
Budinsky RA, LeCluyse EL, Ferguson SS, Rowlands JC, Simon T. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 224-35. PMID 20705892 DOI: 10.1093/Toxsci/Kfq238 |
0.494 |
|
| 2010 |
Lecluyse EL, Alexandre E. Isolation and culture of primary hepatocytes from resected human liver tissue. Methods in Molecular Biology (Clifton, N.J.). 640: 57-82. PMID 20645046 DOI: 10.1007/978-1-60761-688-7_3 |
0.461 |
|
| 2010 |
Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, et al. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 348-58. PMID 20639261 DOI: 10.1093/Toxsci/Kfq220 |
0.631 |
|
| 2010 |
Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS. Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 13: 329-46. PMID 20574906 DOI: 10.1080/10937404.2010.483949 |
0.528 |
|
| 2009 |
Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 23: 43-58. PMID 19202563 DOI: 10.1002/Jbt.20264 |
0.625 |
|
| 2009 |
Zhu H, Elyar J, Foss R, Hemming A, Hall E, Lecluyse EL, Liu C. Primary human hepatocyte culture for HCV study. Methods in Molecular Biology (Clifton, N.J.). 510: 373-82. PMID 19009276 DOI: 10.1007/978-1-59745-394-3_28 |
0.349 |
|
| 2008 |
Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD. Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G570-80. PMID 18635603 DOI: 10.1152/Ajpgi.00542.2007 |
0.397 |
|
| 2007 |
Hewitt NJ, Lecluyse EL, Ferguson SS. Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37: 1196-224. PMID 17968743 DOI: 10.1080/00498250701534893 |
0.328 |
|
| 2007 |
Hewitt NJ, Lechón MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metabolism Reviews. 39: 159-234. PMID 17364884 DOI: 10.1080/03602530601093489 |
0.434 |
|
| 2007 |
Hewitt NJ, de Kanter R, LeCluyse E. Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations? Chemico-Biological Interactions. 168: 51-65. PMID 17239835 DOI: 10.1016/J.Cbi.2006.12.009 |
0.438 |
|
| 2007 |
Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. The Journal of Pharmacology and Experimental Therapeutics. 320: 72-80. PMID 17041008 DOI: 10.1124/Jpet.106.112136 |
0.826 |
|
| 2006 |
Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. The Journal of Pharmacology and Experimental Therapeutics. 319: 1477-84. PMID 16966469 DOI: 10.1124/Jpet.106.111807 |
0.398 |
|
| 2006 |
Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. The Journal of Pharmacology and Experimental Therapeutics. 319: 1467-76. PMID 16943252 DOI: 10.1124/Jpet.106.110577 |
0.395 |
|
| 2006 |
Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL. Cloning, tissue expression, and regulation of beagle dog CYP4A genes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 92: 356-67. PMID 16675513 DOI: 10.1093/Toxsci/Kfl009 |
0.717 |
|
| 2006 |
Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL. Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes. Journal of Biochemical and Molecular Toxicology. 20: 69-78. PMID 16615094 DOI: 10.1002/Jbt.20118 |
0.722 |
|
| 2006 |
Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 317: 1200-9. PMID 16513849 DOI: 10.1124/Jpet.105.098160 |
0.802 |
|
| 2005 |
Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells. The Journal of Pharmacology and Experimental Therapeutics. 315: 1256-64. PMID 16135700 DOI: 10.1124/Jpet.105.090795 |
0.8 |
|
| 2005 |
Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Molecular Pharmacology. 68: 747-57. PMID 15933212 DOI: 10.1124/Mol.105.013169 |
0.51 |
|
| 2005 |
Smith CM, Faucette SR, Wang H, LeCluyse EL. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. Journal of Biochemical and Molecular Toxicology. 19: 96-108. PMID 15849716 DOI: 10.1002/Jbt.20058 |
0.808 |
|
| 2005 |
LeCluyse EL, Alexandre E, Hamilton GA, Viollon-Abadie C, Coon DJ, Jolley S, Richert L. Isolation and culture of primary human hepatocytes. Methods in Molecular Biology (Clifton, N.J.). 290: 207-29. PMID 15361665 DOI: 10.1385/1-59259-838-2:207 |
0.481 |
|
| 2004 |
Drobná Z, Waters SB, Walton FS, LeCluyse EL, Thomas DJ, Stýblo M. Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicology and Applied Pharmacology. 201: 166-77. PMID 15541756 DOI: 10.1016/J.Taap.2004.05.004 |
0.386 |
|
| 2004 |
Hempel N, Wang H, LeCluyse EL, McManus ME, Negishi M. The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein. Molecular Pharmacology. 66: 1690-701. PMID 15383623 DOI: 10.1124/Mol.104.003350 |
0.494 |
|
| 2004 |
Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL. Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1370-6. PMID 15333513 DOI: 10.1124/Dmd.104.000208 |
0.46 |
|
| 2004 |
Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharmaceutical Research. 21: 1294-302. PMID 15290872 DOI: 10.1023/B:Pham.0000033018.97745.0D |
0.406 |
|
| 2004 |
Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. The Journal of Biological Chemistry. 279: 29295-301. PMID 15123723 DOI: 10.1074/Jbc.M400580200 |
0.822 |
|
| 2004 |
Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 359-63. PMID 14977871 DOI: 10.1124/Dmd.32.3.359 |
0.384 |
|
| 2004 |
Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 348-58. PMID 14977870 DOI: 10.1124/Dmd.32.3.348 |
0.818 |
|
| 2003 |
Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clinical Pharmacokinetics. 42: 1331-57. PMID 14674787 DOI: 10.2165/00003088-200342150-00003 |
0.43 |
|
| 2003 |
Luo G, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, et al. Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1170-5. PMID 12920173 DOI: 10.1124/Dmd.31.9.1170 |
0.512 |
|
| 2003 |
Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, ... ... LeCluyse EL, et al. CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 870-7. PMID 12814963 DOI: 10.1124/Dmd.31.7.870 |
0.519 |
|
| 2003 |
Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL. Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 306: 1027-34. PMID 12766253 DOI: 10.1124/Jpet.103.050526 |
0.49 |
|
| 2003 |
Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 620-30. PMID 12695351 DOI: 10.1124/Dmd.31.5.620 |
0.824 |
|
| 2003 |
Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 439-46. PMID 12642470 DOI: 10.1124/Dmd.31.4.439 |
0.481 |
|
| 2003 |
Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan LS, LeCluyse EL, Zech K, Robertson P, Koch P, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 421-31. PMID 12642468 DOI: 10.1124/Dmd.31.4.421 |
0.658 |
|
| 2003 |
Walton FS, Waters SB, Jolley SL, LeCluyse EL, Thomas DJ, Styblo M. Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chemical Research in Toxicology. 16: 261-5. PMID 12641425 DOI: 10.1021/Tx025649R |
0.386 |
|
| 2003 |
Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. The Journal of Biological Chemistry. 278: 14146-52. PMID 12571232 DOI: 10.1074/Jbc.M212482200 |
0.809 |
|
| 2002 |
Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Molecular Pharmacology. 62: 737-46. PMID 12181452 DOI: 10.1124/Mol.62.3.737 |
0.522 |
|
| 2002 |
Lindley C, Hamilton G, McCune JS, Faucette S, Shord SS, Hawke RL, Wang H, Gilbert D, Jolley S, Yan B, LeCluyse EL. The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 814-22. PMID 12065440 DOI: 10.1124/Dmd.30.7.814 |
0.814 |
|
| 2002 |
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, ... ... LeCluyse E, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 795-804. PMID 12065438 DOI: 10.1124/Dmd.30.7.795 |
0.775 |
|
| 2002 |
Richert L, Binda D, Hamilton G, Viollon-Abadie C, Alexandre E, Bigot-Lasserre D, Bars R, Coassolo P, LeCluyse E. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 16: 89-99. PMID 11812644 DOI: 10.1016/S0887-2333(01)00099-6 |
0.38 |
|
| 2002 |
Chandra P, Lecluyse EL, Brouwer KL. Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes. In Vitro Cellular & Developmental Biology. Animal. 37: 380-5. PMID 11515972 DOI: 10.1007/Bf02577575 |
0.326 |
|
| 2001 |
Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, LeCluyse EL. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell and Tissue Research. 306: 85-99. PMID 11683185 DOI: 10.1007/S004410100429 |
0.427 |
|
| 2001 |
Faucette SR, Hawke RL, Shord SS, Lecluyse EL, Lindley CM. Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1123-9. PMID 11454731 |
0.798 |
|
| 2001 |
LeCluyse EL. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 13: 343-68. PMID 11408150 DOI: 10.1016/S0928-0987(01)00135-X |
0.539 |
|
| 2001 |
LeCluyse EL. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chemico-Biological Interactions. 134: 283-9. PMID 11336976 DOI: 10.1016/S0009-2797(01)00163-6 |
0.533 |
|
| 2001 |
Lu T, Liu J, LeCluyse EL, Zhou YS, Cheng ML, Waalkes MP. Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicological Sciences : An Official Journal of the Society of Toxicology. 59: 185-92. PMID 11134558 DOI: 10.1093/Toxsci/59.1.185 |
0.435 |
|
| 2000 |
McCune JS, Hawke RL, LeCluyse EL, Gillenwater HH, Hamilton G, Ritchie J, Lindley C. In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone Clinical Pharmacology and Therapeutics. 68: 356-366. PMID 11061575 DOI: 10.1067/mcp.2000.110215 |
0.427 |
|
| 2000 |
Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology. 74: 289-99. PMID 11005674 DOI: 10.1007/S002040000134 |
0.325 |
|
| 2000 |
Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1222-30. PMID 10997944 |
0.779 |
|
| 2000 |
LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 14: 177-88. PMID 10789495 DOI: 10.1002/(Sici)1099-0461(2000)14:4<177::Aid-Jbt1>3.0.Co;2-4 |
0.489 |
|
| 2000 |
Sahi J, Hamilton G, Sinz M, Barros S, Huang SM, Lesko LJ, LeCluyse EL. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 273-84. PMID 10752642 DOI: 10.1080/004982500237668 |
0.431 |
|
| 2000 |
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NCO, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution Molecular Endocrinology. 14: 27-39. PMID 10628745 DOI: 10.1210/Me.14.1.27 |
0.587 |
|
| 1999 |
Liu DZ, LeCluyse EL, Thakker DR. Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 88: 1161-8. PMID 10564065 DOI: 10.1021/Js990094E |
0.335 |
|
| 1999 |
Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR, Thomas DJ. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chemical Research in Toxicology. 12: 560-5. PMID 10409394 DOI: 10.1021/Tx990050L |
0.375 |
|
| 1999 |
Liu X, LeCluyse EL, Brouwer KR, Gan LS, Lemasters JJ, Stieger B, Meier PJ, Brouwer KL. Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. The American Journal of Physiology. 277: G12-21. PMID 10409146 DOI: 10.1152/Ajpgi.1999.277.1.G12 |
0.313 |
|
| 1999 |
MCCUNE J, HAWKE R, LECLUYSE E, GILLENWATER H, RITCHIE J, LINDLEY C. Dexamethasone induction of cytochrome P450 3A4 activity in human hepatocytes and healthy volunteers Clinical Pharmacology & Therapeutics. 65: 195-195. DOI: 10.1016/S0009-9236(99)80311-7 |
0.304 |
|
| 1999 |
LECLUYSE E, SAHI J, SINZ M, WOOLF T, HAWKE R, HAMILTON G, LESKO L, HUANG S. Troglitazone induces CYP3A4 in cultured human hepatocytes Clinical Pharmacology & Therapeutics. 65: 157-157. DOI: 10.1016/S0009-9236(99)80158-1 |
0.461 |
|
| 1997 |
LeCluyse EL, Sutton SC. In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement Advanced Drug Delivery Reviews. 23: 163-183. DOI: 10.1016/S0169-409X(96)00434-6 |
0.311 |
|
| 1996 |
LeCluyse EL, Bullock PL, Parkinson A. Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes Advanced Drug Delivery Reviews. 22: 133-186. DOI: 10.1016/S0169-409X(96)00418-8 |
0.305 |
|
| 1992 |
Sutton SC, Forbes AE, Cargill R, Hochman JH, LeCluyse EL. Simultaneous in vitro measurement of intestinal tissue permeability and transepithelial electrical resistance (TEER) using Sweetana-Grass diffusion cells. Pharmaceutical Research. 9: 316-9. PMID 1614963 DOI: 10.1023/A:1015878516157 |
0.301 |
|
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