Edward L. LeCluyse - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Molecular Biology, Cell Biology

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ware BR, Brown GE, Soldatow VY, LeCluyse EL, Khetani SR. ERRATUM. Gene Expression. 20: 75-76. PMID 32522329 DOI: 10.3727/105221620X15886997679754  0.318
2019 Deisenroth C, Soldatow VY, Ford J, Stewart W, Brinkman C, LeCluyse EL, MacMillan DK, Thomas RS. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31808822 DOI: 10.1093/Toxsci/Kfz238  0.361
2019 McMullen PD, Bhattacharya S, Woods CG, Pendse SN, McBride MT, Soldatow VY, Deisenroth C, LeCluyse EL, Clewell RA, Andersen ME. Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 31628012 DOI: 10.1016/J.Tiv.2019.02.017  0.305
2019 Ware BR, Brown GE, Soldatow VY, LeCluyse EL, Khetani SR. Long-term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development. Gene Expression. PMID 31340881 DOI: 10.3727/105221619X15638857793317  0.307
2019 Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31093666 DOI: 10.1093/Toxsci/Kfz112  0.385
2018 Baker EJ, Beck NA, Berg EL, Clayton-Jeter HD, Chandrasekera PC, Curley JL, Donzanti BA, Ewart LC, Gunther JM, Kenna JG, LeCluyse EL, Liebman MN, Pugh CL, Watkins PB, Sullivan KM. Advancing nonclinical innovation and safety in pharmaceutical testing. Drug Discovery Today. PMID 30468877 DOI: 10.1016/J.Drudis.2018.11.011  0.378
2017 Mosedale M, Eaddy JS, Trask OJ, Holman NS, Wolf KK, LeCluyse E, Ware BR, Khetani SR, Lu J, Brock WJ, Roth SE, Watkins PB. miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29029277 DOI: 10.1093/Toxsci/Kfx206  0.333
2017 Tikunov AP, Shim YS, Bhattarai N, Siler SQ, Soldatow V, LeCluyse EL, McDunn JE, Watkins PB, Macdonald JM. Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 28867505 DOI: 10.1016/J.Tiv.2017.08.021  0.356
2016 Norona LM, Nguyen DG, Gerber DA, Presnell SC, LeCluyse EL. Modeling compound-induced fibrogenesis in vitro using three-dimensional bioprinted human liver tissues. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27605418 DOI: 10.1093/Toxsci/Kfw169  0.363
2016 Soldatow V, Peffer RC, Trask OJ, Cowie DE, Andersen ME, LeCluyse E, Deisenroth C. Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 27530964 DOI: 10.1016/j.tiv.2016.08.006  0.408
2016 Holman NS, Mosedale M, Wolf KK, LeCluyse EL, Watkins PB. Sub-toxic alterations in hepatocyte-derived exosomes: an early step in drug-induced liver injury? Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26962055 DOI: 10.1093/Toxsci/Kfw047  0.388
2016 Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL. Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. Journal of Pharmaceutical Sciences. 105: 950-64. PMID 26869439 DOI: 10.1016/S0022-3549(15)00192-6  0.419
2015 Lu J, Einhorn S, Venkatarangan L, Miller M, Mann DA, Watkins PB, LeCluyse E. Morphological and Functional Characterization and Assessment of iPSC-derived Hepatocytes for In Vitro Toxicity Testing. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26092927 DOI: 10.1093/toxsci/kfv117  0.331
2014 Trask OJ, Moore A, LeCluyse EL. A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis. Assay and Drug Development Technologies. 12: 16-27. PMID 24444127 DOI: 10.1089/Adt.2013.525  0.391
2014 Choi K, Pfund WP, Andersen ME, Thomas RS, Clewell HJ, LeCluyse EL. Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin. Tissue Engineering. Part C, Methods. 20: 641-51. PMID 24294911 DOI: 10.1089/ten.TEC.2013.0562  0.309
2014 McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions. 209: 14-24. PMID 24269660 DOI: 10.1016/J.Cbi.2013.11.006  0.378
2013 Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, ... ... LeCluyse EL, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology. 87: 1315-530. PMID 23974980 DOI: 10.1007/S00204-013-1078-5  0.401
2013 Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Toxicology and Applied Pharmacology. 272: 503-18. PMID 23859880 DOI: 10.1016/J.Taap.2013.06.024  0.399
2013 Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2Tx20051A  0.387
2012 Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Journal of Pharmaceutical Sciences. 101: 3989-4002. PMID 22806329 DOI: 10.1002/Jps.23262  0.692
2012 LeCluyse EL, Witek RP, Andersen ME, Powers MJ. Organotypic liver culture models: meeting current challenges in toxicity testing. Critical Reviews in Toxicology. 42: 501-48. PMID 22582993 DOI: 10.3109/10408444.2012.682115  0.316
2012 Black MB, Budinsky RA, Dombkowski A, Cukovic D, LeCluyse EL, Ferguson SS, Thomas RS, Rowlands JC. Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 199-215. PMID 22298810 DOI: 10.1093/Toxsci/Kfs069  0.455
2010 Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I. Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicology and Applied Pharmacology. 249: 208-16. PMID 20869979 DOI: 10.1016/J.Taap.2010.09.012  0.344
2010 Budinsky RA, LeCluyse EL, Ferguson SS, Rowlands JC, Simon T. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 224-35. PMID 20705892 DOI: 10.1093/Toxsci/Kfq238  0.494
2010 Lecluyse EL, Alexandre E. Isolation and culture of primary hepatocytes from resected human liver tissue. Methods in Molecular Biology (Clifton, N.J.). 640: 57-82. PMID 20645046 DOI: 10.1007/978-1-60761-688-7_3  0.461
2010 Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, et al. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 348-58. PMID 20639261 DOI: 10.1093/Toxsci/Kfq220  0.632
2010 Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS. Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 13: 329-46. PMID 20574906 DOI: 10.1080/10937404.2010.483949  0.528
2009 Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 23: 43-58. PMID 19202563 DOI: 10.1002/Jbt.20264  0.625
2009 Zhu H, Elyar J, Foss R, Hemming A, Hall E, Lecluyse EL, Liu C. Primary human hepatocyte culture for HCV study. Methods in Molecular Biology (Clifton, N.J.). 510: 373-82. PMID 19009276 DOI: 10.1007/978-1-59745-394-3_28  0.349
2008 Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD. Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G570-80. PMID 18635603 DOI: 10.1152/Ajpgi.00542.2007  0.397
2007 Hewitt NJ, Lecluyse EL, Ferguson SS. Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37: 1196-224. PMID 17968743 DOI: 10.1080/00498250701534893  0.328
2007 Hewitt NJ, Lechón MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metabolism Reviews. 39: 159-234. PMID 17364884 DOI: 10.1080/03602530601093489  0.434
2007 Hewitt NJ, de Kanter R, LeCluyse E. Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations? Chemico-Biological Interactions. 168: 51-65. PMID 17239835 DOI: 10.1016/J.Cbi.2006.12.009  0.438
2007 Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. The Journal of Pharmacology and Experimental Therapeutics. 320: 72-80. PMID 17041008 DOI: 10.1124/Jpet.106.112136  0.826
2006 Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. The Journal of Pharmacology and Experimental Therapeutics. 319: 1477-84. PMID 16966469 DOI: 10.1124/Jpet.106.111807  0.398
2006 Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. The Journal of Pharmacology and Experimental Therapeutics. 319: 1467-76. PMID 16943252 DOI: 10.1124/Jpet.106.110577  0.395
2006 Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL. Cloning, tissue expression, and regulation of beagle dog CYP4A genes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 92: 356-67. PMID 16675513 DOI: 10.1093/Toxsci/Kfl009  0.723
2006 Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL. Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes. Journal of Biochemical and Molecular Toxicology. 20: 69-78. PMID 16615094 DOI: 10.1002/Jbt.20118  0.728
2006 Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 317: 1200-9. PMID 16513849 DOI: 10.1124/Jpet.105.098160  0.803
2005 Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells. The Journal of Pharmacology and Experimental Therapeutics. 315: 1256-64. PMID 16135700 DOI: 10.1124/Jpet.105.090795  0.802
2005 Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Molecular Pharmacology. 68: 747-57. PMID 15933212 DOI: 10.1124/Mol.105.013169  0.51
2005 Smith CM, Faucette SR, Wang H, LeCluyse EL. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. Journal of Biochemical and Molecular Toxicology. 19: 96-108. PMID 15849716 DOI: 10.1002/Jbt.20058  0.809
2005 LeCluyse EL, Alexandre E, Hamilton GA, Viollon-Abadie C, Coon DJ, Jolley S, Richert L. Isolation and culture of primary human hepatocytes. Methods in Molecular Biology (Clifton, N.J.). 290: 207-29. PMID 15361665 DOI: 10.1385/1-59259-838-2:207  0.481
2004 Drobná Z, Waters SB, Walton FS, LeCluyse EL, Thomas DJ, Stýblo M. Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicology and Applied Pharmacology. 201: 166-77. PMID 15541756 DOI: 10.1016/J.Taap.2004.05.004  0.386
2004 Hempel N, Wang H, LeCluyse EL, McManus ME, Negishi M. The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein. Molecular Pharmacology. 66: 1690-701. PMID 15383623 DOI: 10.1124/Mol.104.003350  0.494
2004 Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL. Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1370-6. PMID 15333513 DOI: 10.1124/Dmd.104.000208  0.461
2004 Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharmaceutical Research. 21: 1294-302. PMID 15290872 DOI: 10.1023/B:Pham.0000033018.97745.0D  0.406
2004 Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. The Journal of Biological Chemistry. 279: 29295-301. PMID 15123723 DOI: 10.1074/Jbc.M400580200  0.822
2004 Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 359-63. PMID 14977871 DOI: 10.1124/Dmd.32.3.359  0.384
2004 Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 348-58. PMID 14977870 DOI: 10.1124/Dmd.32.3.348  0.818
2003 Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clinical Pharmacokinetics. 42: 1331-57. PMID 14674787 DOI: 10.2165/00003088-200342150-00003  0.43
2003 Luo G, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, et al. Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1170-5. PMID 12920173 DOI: 10.1124/Dmd.31.9.1170  0.512
2003 Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, ... ... LeCluyse EL, et al. CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 870-7. PMID 12814963 DOI: 10.1124/Dmd.31.7.870  0.519
2003 Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL. Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 306: 1027-34. PMID 12766253 DOI: 10.1124/Jpet.103.050526  0.491
2003 Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 620-30. PMID 12695351 DOI: 10.1124/Dmd.31.5.620  0.825
2003 Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 439-46. PMID 12642470 DOI: 10.1124/Dmd.31.4.439  0.482
2003 Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan LS, LeCluyse EL, Zech K, Robertson P, Koch P, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 421-31. PMID 12642468 DOI: 10.1124/Dmd.31.4.421  0.666
2003 Walton FS, Waters SB, Jolley SL, LeCluyse EL, Thomas DJ, Styblo M. Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chemical Research in Toxicology. 16: 261-5. PMID 12641425 DOI: 10.1021/Tx025649R  0.386
2003 Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. The Journal of Biological Chemistry. 278: 14146-52. PMID 12571232 DOI: 10.1074/Jbc.M212482200  0.809
2002 Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Molecular Pharmacology. 62: 737-46. PMID 12181452 DOI: 10.1124/Mol.62.3.737  0.522
2002 Lindley C, Hamilton G, McCune JS, Faucette S, Shord SS, Hawke RL, Wang H, Gilbert D, Jolley S, Yan B, LeCluyse EL. The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 814-22. PMID 12065440 DOI: 10.1124/Dmd.30.7.814  0.815
2002 Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, ... ... LeCluyse E, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 795-804. PMID 12065438 DOI: 10.1124/Dmd.30.7.795  0.78
2002 Richert L, Binda D, Hamilton G, Viollon-Abadie C, Alexandre E, Bigot-Lasserre D, Bars R, Coassolo P, LeCluyse E. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 16: 89-99. PMID 11812644 DOI: 10.1016/S0887-2333(01)00099-6  0.38
2002 Chandra P, Lecluyse EL, Brouwer KL. Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes. In Vitro Cellular & Developmental Biology. Animal. 37: 380-5. PMID 11515972 DOI: 10.1007/Bf02577575  0.326
2001 Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, LeCluyse EL. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell and Tissue Research. 306: 85-99. PMID 11683185 DOI: 10.1007/S004410100429  0.427
2001 Faucette SR, Hawke RL, Shord SS, Lecluyse EL, Lindley CM. Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1123-9. PMID 11454731  0.798
2001 LeCluyse EL. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 13: 343-68. PMID 11408150 DOI: 10.1016/S0928-0987(01)00135-X  0.539
2001 LeCluyse EL. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chemico-Biological Interactions. 134: 283-9. PMID 11336976 DOI: 10.1016/S0009-2797(01)00163-6  0.533
2001 Lu T, Liu J, LeCluyse EL, Zhou YS, Cheng ML, Waalkes MP. Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicological Sciences : An Official Journal of the Society of Toxicology. 59: 185-92. PMID 11134558 DOI: 10.1093/Toxsci/59.1.185  0.435
2000 McCune JS, Hawke RL, LeCluyse EL, Gillenwater HH, Hamilton G, Ritchie J, Lindley C. In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone Clinical Pharmacology and Therapeutics. 68: 356-366. PMID 11061575 DOI: 10.1067/mcp.2000.110215  0.427
2000 Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology. 74: 289-99. PMID 11005674 DOI: 10.1007/S002040000134  0.325
2000 Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1222-30. PMID 10997944  0.779
2000 LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 14: 177-88. PMID 10789495 DOI: 10.1002/(Sici)1099-0461(2000)14:4<177::Aid-Jbt1>3.0.Co;2-4  0.489
2000 Sahi J, Hamilton G, Sinz M, Barros S, Huang SM, Lesko LJ, LeCluyse EL. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 273-84. PMID 10752642 DOI: 10.1080/004982500237668  0.432
2000 Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NCO, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution Molecular Endocrinology. 14: 27-39. PMID 10628745 DOI: 10.1210/Me.14.1.27  0.587
1999 Liu DZ, LeCluyse EL, Thakker DR. Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 88: 1161-8. PMID 10564065 DOI: 10.1021/Js990094E  0.335
1999 Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR, Thomas DJ. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chemical Research in Toxicology. 12: 560-5. PMID 10409394 DOI: 10.1021/Tx990050L  0.375
1999 Liu X, LeCluyse EL, Brouwer KR, Gan LS, Lemasters JJ, Stieger B, Meier PJ, Brouwer KL. Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. The American Journal of Physiology. 277: G12-21. PMID 10409146 DOI: 10.1152/Ajpgi.1999.277.1.G12  0.314
1999 MCCUNE J, HAWKE R, LECLUYSE E, GILLENWATER H, RITCHIE J, LINDLEY C. Dexamethasone induction of cytochrome P450 3A4 activity in human hepatocytes and healthy volunteers Clinical Pharmacology & Therapeutics. 65: 195-195. DOI: 10.1016/S0009-9236(99)80311-7  0.305
1999 LECLUYSE E, SAHI J, SINZ M, WOOLF T, HAWKE R, HAMILTON G, LESKO L, HUANG S. Troglitazone induces CYP3A4 in cultured human hepatocytes Clinical Pharmacology & Therapeutics. 65: 157-157. DOI: 10.1016/S0009-9236(99)80158-1  0.461
1997 LeCluyse EL, Sutton SC. In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement Advanced Drug Delivery Reviews. 23: 163-183. DOI: 10.1016/S0169-409X(96)00434-6  0.311
1996 LeCluyse EL, Bullock PL, Parkinson A. Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes Advanced Drug Delivery Reviews. 22: 133-186. DOI: 10.1016/S0169-409X(96)00418-8  0.305
1992 Sutton SC, Forbes AE, Cargill R, Hochman JH, LeCluyse EL. Simultaneous in vitro measurement of intestinal tissue permeability and transepithelial electrical resistance (TEER) using Sweetana-Grass diffusion cells. Pharmaceutical Research. 9: 316-9. PMID 1614963 DOI: 10.1023/A:1015878516157  0.301
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