Edward L. LeCluyse - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Molecular Biology, Cell Biology

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL. Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. Journal of Pharmaceutical Sciences. 105: 950-64. PMID 26869439 DOI: 10.1016/S0022-3549(15)00192-6  0.44
2014 Harrill AH, Eaddy JS, Rose K, Cullen JM, Ramanathan L, Wanaski S, Collins S, Ho Y, Watkins PB, Lecluyse EL. Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260. Toxicology and Applied Pharmacology. 277: 131-7. PMID 24699182 DOI: 10.1016/j.taap.2014.03.015  0.44
2014 McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions. 209: 14-24. PMID 24269660 DOI: 10.1016/j.cbi.2013.11.006  0.44
2013 Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, ... ... LeCluyse EL, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology. 87: 1315-530. PMID 23974980 DOI: 10.1007/s00204-013-1078-5  0.44
2013 Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2TX20051A  0.44
2012 Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Journal of Pharmaceutical Sciences. 101: 3989-4002. PMID 22806329 DOI: 10.1002/jps.23262  0.44
2012 LeCluyse EL, Witek RP, Andersen ME, Powers MJ. Organotypic liver culture models: meeting current challenges in toxicity testing. Critical Reviews in Toxicology. 42: 501-48. PMID 22582993 DOI: 10.3109/10408444.2012.682115  0.44
2012 Black MB, Budinsky RA, Dombkowski A, Cukovic D, LeCluyse EL, Ferguson SS, Thomas RS, Rowlands JC. Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 199-215. PMID 22298810 DOI: 10.1093/toxsci/kfs069  0.44
2010 Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I. Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicology and Applied Pharmacology. 249: 208-16. PMID 20869979 DOI: 10.1016/j.taap.2010.09.012  0.44
2010 Budinsky RA, LeCluyse EL, Ferguson SS, Rowlands JC, Simon T. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 224-35. PMID 20705892 DOI: 10.1093/toxsci/kfq238  0.44
2010 Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, et al. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 348-58. PMID 20639261 DOI: 10.1093/toxsci/kfq220  0.44
2010 Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS. Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. Journal of Toxicology and Environmental Health. Part B, Critical Reviews. 13: 329-46. PMID 20574906 DOI: 10.1080/10937404.2010.483949  0.44
2009 Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 23: 43-58. PMID 19202563 DOI: 10.1002/jbt.20264  0.44
2007 Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. The Journal of Pharmacology and Experimental Therapeutics. 320: 72-80. PMID 17041008 DOI: 10.1124/jpet.106.112136  0.6
2006 Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. The Journal of Pharmacology and Experimental Therapeutics. 319: 1477-84. PMID 16966469 DOI: 10.1124/jpet.106.111807  0.32
2006 Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. The Journal of Pharmacology and Experimental Therapeutics. 319: 1467-76. PMID 16943252 DOI: 10.1124/jpet.106.110577  0.32
2006 Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL. Cloning, tissue expression, and regulation of beagle dog CYP4A genes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 92: 356-67. PMID 16675513 DOI: 10.1093/toxsci/kfl009  0.48
2006 Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL. Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes. Journal of Biochemical and Molecular Toxicology. 20: 69-78. PMID 16615094 DOI: 10.1002/jbt.20118  0.48
2006 Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 317: 1200-9. PMID 16513849 DOI: 10.1124/jpet.105.098160  0.6
2005 Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells. The Journal of Pharmacology and Experimental Therapeutics. 315: 1256-64. PMID 16135700 DOI: 10.1124/jpet.105.090795  0.6
2005 Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Molecular Pharmacology. 68: 747-57. PMID 15933212 DOI: 10.1124/mol.105.013169  0.48
2005 Smith CM, Faucette SR, Wang H, LeCluyse EL. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. Journal of Biochemical and Molecular Toxicology. 19: 96-108. PMID 15849716 DOI: 10.1002/jbt.20058  0.6
2005 LeCluyse EL, Alexandre E, Hamilton GA, Viollon-Abadie C, Coon DJ, Jolley S, Richert L. Isolation and culture of primary human hepatocytes. Methods in Molecular Biology (Clifton, N.J.). 290: 207-29. PMID 15361665  0.44
2004 Hempel N, Wang H, LeCluyse EL, McManus ME, Negishi M. The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein. Molecular Pharmacology. 66: 1690-701. PMID 15383623 DOI: 10.1124/mol.104.003350  0.6
2004 Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL. Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1370-6. PMID 15333513 DOI: 10.1124/dmd.104.000208  0.44
2004 Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharmaceutical Research. 21: 1294-302. PMID 15290872 DOI: 10.1023/B:PHAM.0000033018.97745.0d  0.44
2004 Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 359-63. PMID 14977871 DOI: 10.1124/dmd.32.3.359  0.44
2004 Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 348-58. PMID 14977870 DOI: 10.1124/dmd.32.3.348  0.6
2003 Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clinical Pharmacokinetics. 42: 1331-57. PMID 14674787 DOI: 10.2165/00003088-200342150-00003  0.6
2003 Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, ... ... LeCluyse EL, et al. CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 870-7. PMID 12814963 DOI: 10.1124/dmd.31.7.870  0.44
2003 Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL. Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. The Journal of Pharmacology and Experimental Therapeutics. 306: 1027-34. PMID 12766253 DOI: 10.1124/jpet.103.050526  0.44
2003 Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 620-30. PMID 12695351  0.6
2003 Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 439-46. PMID 12642470 DOI: 10.1124/dmd.31.4.439  0.44
2003 Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan LS, LeCluyse EL, Zech K, Robertson P, Koch P, et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 421-31. PMID 12642468 DOI: 10.1124/dmd.31.4.421  0.44
2003 Walton FS, Waters SB, Jolley SL, LeCluyse EL, Thomas DJ, Styblo M. Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chemical Research in Toxicology. 16: 261-5. PMID 12641425 DOI: 10.1021/tx025649r  0.32
2003 Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. The Journal of Biological Chemistry. 278: 14146-52. PMID 12571232 DOI: 10.1074/jbc.M212482200  0.6
2002 Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Molecular Pharmacology. 62: 737-46. PMID 12181452  0.48
2002 Lindley C, Hamilton G, McCune JS, Faucette S, Shord SS, Hawke RL, Wang H, Gilbert D, Jolley S, Yan B, LeCluyse EL. The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 814-22. PMID 12065440  0.6
2001 Faucette SR, Hawke RL, Shord SS, Lecluyse EL, Lindley CM. Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1123-9. PMID 11454731  0.6
2000 Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1222-30. PMID 10997944  0.6
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