| Year |
Citation |
Score |
| 2019 |
Park S, Hwang SY, Shin J, Jo H, Na Y, Kwon Y. A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform. Chemical Communications (Cambridge, England). PMID 31598611 DOI: 10.1039/C9Cc05524J |
0.365 |
|
| 2018 |
Cho H, Hee Seo S, Na Y, Kwon Y. The synthesis and anticancer activities of chiral epoxy-substituted chromone analogs. Bioorganic Chemistry. 84: 347-354. PMID 30530076 DOI: 10.1016/J.Bioorg.2018.11.054 |
0.476 |
|
| 2018 |
An H, Lee S, Lee JM, Jo DH, Kim J, Jeong YS, Heo MJ, Cho CS, Choi H, Seo JH, Hwang S, Lim J, Kim T, Jun HO, Sim J, ... ... Na Y, et al. Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy. Journal of Medicinal Chemistry. PMID 30252468 DOI: 10.1021/Acs.Jmedchem.8B00971 |
0.324 |
|
| 2018 |
Moon H, Yoon H, Lim C, Jang J, Yi JJ, Lee JK, Lee J, Na Y, Son WS, Kim SH, Suh YG. Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A₁ via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions. Molecules (Basel, Switzerland). 23. PMID 30223428 DOI: 10.3390/Molecules23092351 |
0.331 |
|
| 2017 |
Choi B, Choi SK, Park YN, Kwak SY, Lee HJ, Kwon Y, Na Y, Lee YS. Sensitization of lung cancer cells by altered dimerization of HSP27. Oncotarget. 8: 105372-105382. PMID 29285257 DOI: 10.18632/Oncotarget.22192 |
0.379 |
|
| 2017 |
Hwang SY, Kwak SY, Kwon Y, Lee YS, Na Y. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27. European Journal of Medicinal Chemistry. 139: 892-900. PMID 28869891 DOI: 10.1016/J.Ejmech.2017.08.065 |
0.413 |
|
| 2017 |
Choi SK, Mun GI, Choi E, Kim SY, Kwon Y, Na Y, Lee YS. The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection. Journal of Natural Products. PMID 28737916 DOI: 10.1021/Acs.Jnatprod.7B00126 |
0.309 |
|
| 2016 |
Jeon KH, Yu HB, Kwak SY, Kwon Y, Na Y. Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones. Bioorganic & Medicinal Chemistry. PMID 27707625 DOI: 10.1016/J.Bmc.2016.09.051 |
0.445 |
|
| 2016 |
Park S, Hong E, Kwak SY, Jun KY, Lee ES, Kwon Y, Na Y. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. European Journal of Medicinal Chemistry. 123: 211-225. PMID 27484510 DOI: 10.1016/J.Ejmech.2016.07.046 |
0.465 |
|
| 2016 |
Kim JH, Jung YJ, Choi B, Lee NL, Lee HJ, Kwak SY, Kwon Y, Na Y, Lee YS. Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules. Oncotarget. PMID 27449291 DOI: 10.18632/Oncotarget.10629 |
0.326 |
|
| 2016 |
Jeon KH, Lee E, Jun KY, Eom JE, Kwak SY, Na Y, Kwon Y. Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation. European Journal of Medicinal Chemistry. 121: 433-444. PMID 27318120 DOI: 10.1016/J.Ejmech.2016.06.008 |
0.418 |
|
| 2016 |
Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents. Bioorganic Chemistry. 66: 145-159. PMID 27174797 DOI: 10.1016/J.Bioorg.2016.04.007 |
0.47 |
|
| 2016 |
Baek KH, Yu HV, Kim E, Na Y, Kwon Y. Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway. Oncotarget. PMID 27121057 DOI: 10.18632/Oncotarget.8791 |
0.3 |
|
| 2016 |
Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. European Journal of Medicinal Chemistry. 113: 228-245. PMID 26945111 DOI: 10.1016/J.Ejmech.2016.02.050 |
0.465 |
|
| 2016 |
Kadayat TM, Park S, Jun KY, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry Letters. PMID 26927425 DOI: 10.1016/J.Bmcl.2016.02.053 |
0.449 |
|
| 2015 |
Thapa P, Jun KY, Kadayat TM, Park C, Zheng Z, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents. Bioorganic & Medicinal Chemistry. PMID 26361737 DOI: 10.1016/J.Bmc.2015.08.018 |
0.433 |
|
| 2015 |
Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry. 23: 3499-512. PMID 26022080 DOI: 10.1016/J.Bmc.2015.04.031 |
0.468 |
|
| 2015 |
Karki R, Song C, Kadayat TM, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines. Bioorganic & Medicinal Chemistry. 23: 3638-54. PMID 25936262 DOI: 10.1016/j.bmc.2015.04.002 |
0.375 |
|
| 2015 |
Kwon HB, Park C, Jeon KH, Lee E, Park SE, Jun KY, Kadayat TM, Thapa P, Karki R, Na Y, Park MS, Rho SB, Lee ES, Kwon Y. A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. Journal of Medicinal Chemistry. 58: 1100-22. PMID 25603122 DOI: 10.1021/Jm501023Q |
0.417 |
|
| 2014 |
Jin CH, Jun KY, Lee E, Kim S, Kwon Y, Kim K, Na Y. Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor. Bioorganic & Medicinal Chemistry. 22: 4553-65. PMID 25131958 DOI: 10.1016/J.Bmc.2014.07.037 |
0.421 |
|
| 2013 |
Baek KH, Karki R, Lee ES, Na Y, Kwon Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorganic Chemistry. 51: 24-30. PMID 24095934 DOI: 10.1016/J.Bioorg.2013.09.002 |
0.377 |
|
| 2013 |
Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y. 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage. European Journal of Medicinal Chemistry. 69: 139-45. PMID 24013413 DOI: 10.1016/J.Ejmech.2013.07.048 |
0.441 |
|
| 2013 |
Nam JM, Jeon KH, Kwon H, Lee E, Jun KY, Jin YB, Lee YS, Na Y, Kwon Y. Dithiiranylmethyloxy azaxanthone shows potent anti-tumor activity via suppression of HER2 expression and HER2-mediated signals in HER2-overexpressing breast cancer cells. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 181-90. PMID 23835029 DOI: 10.1016/J.Ejps.2013.06.014 |
0.308 |
|
| 2013 |
Kim SH, Lee E, Baek KH, Kwon HB, Woo H, Lee ES, Kwon Y, Na Y. Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 23: 3320-4. PMID 23608763 DOI: 10.1016/J.Bmcl.2013.03.106 |
0.406 |
|
| 2012 |
Kim HL, Jeon KH, Jun KY, Choi Y, Kim DK, Na Y, Kwon Y. A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. Cancer Letters. 325: 72-9. PMID 22732416 DOI: 10.1016/J.Canlet.2012.06.004 |
0.344 |
|
| 2012 |
Thapa P, Karki R, Yun M, Kadayat TM, Lee E, Kwon HB, Na Y, Cho WJ, Kim ND, Jeong BS, Kwon Y, Lee ES. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety. European Journal of Medicinal Chemistry. 52: 123-36. PMID 22503656 DOI: 10.1016/J.Ejmech.2012.03.010 |
0.453 |
|
| 2012 |
Thapa P, Karki R, Yoo HY, Park PH, Lee E, Jeon KH, Na Y, Cho WJ, Kwon Y, Lee ES. 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic Chemistry. 40: 67-78. PMID 22000119 DOI: 10.1016/J.Bioorg.2011.09.001 |
0.392 |
|
| 2011 |
Thapa U, Thapa P, Karki R, Yun M, Choi JH, Jahng Y, Lee E, Jeon KH, Na Y, Ha EM, Cho WJ, Kwon Y, Lee ES. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. European Journal of Medicinal Chemistry. 46: 3201-9. PMID 21601964 DOI: 10.1016/j.ejmech.2011.04.029 |
0.315 |
|
| 2011 |
Sapkota K, Roh E, Lee E, Ha EM, Yang JH, Lee ES, Kwon Y, Kim Y, Na Y. Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues. Bioorganic & Medicinal Chemistry. 19: 2168-75. PMID 21429753 DOI: 10.1016/J.Bmc.2011.02.044 |
0.448 |
|
| 2011 |
Jun KY, Lee EY, Jung MJ, Lee OH, Lee ES, Park Choo HY, Na Y, Kwon Y. Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. European Journal of Medicinal Chemistry. 46: 1964-71. PMID 21419530 DOI: 10.1016/J.Ejmech.2011.01.011 |
0.443 |
|
| 2011 |
Na Y, Nam JM. Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives. Bioorganic & Medicinal Chemistry Letters. 21: 211-4. PMID 21115246 DOI: 10.1016/j.bmcl.2010.11.037 |
0.358 |
|
| 2011 |
Lee E, Jang I, Shin MJ, Cho HJ, Kim J, Eom JE, Kwon Y, Na Y. Chalcones as novel non-peptidic μ-calpain inhibitors Bulletin of the Korean Chemical Society. 32: 3459-3464. DOI: 10.5012/Bkcs.2011.32.9.3459 |
0.341 |
|
| 2011 |
Jeong BS, Choi H, Thapa P, Karki R, Lee E, Nam JM, Na Y, Ha EM, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of rigid analogues of 2,4,6-trisubstituted pyridine containing 5,6-dihydrobenzo[h]quinoline moiety Bulletin of the Korean Chemical Society. 32: 303-306. DOI: 10.5012/Bkcs.2011.32.1.303 |
0.34 |
|
| 2010 |
Woo S, Kang DH, Nam JM, Lee CS, Ha EM, Lee ES, Kwon Y, Na Y. Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. European Journal of Medicinal Chemistry. 45: 4221-8. PMID 20619511 DOI: 10.1016/j.ejmech.2010.06.017 |
0.366 |
|
| 2010 |
Karki R, Thapa P, Kang MJ, Jeong TC, Nam JM, Kim HL, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. Bioorganic & Medicinal Chemistry. 18: 3066-77. PMID 20392646 DOI: 10.1016/j.bmc.2010.03.051 |
0.338 |
|
| 2010 |
Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jung MJ, Nam JM, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorganic & Medicinal Chemistry. 18: 2245-54. PMID 20188578 DOI: 10.1016/j.bmc.2010.01.065 |
0.338 |
|
| 2010 |
Cho HJ, Jung MJ, Woo S, Kim J, Lee ES, Kwon Y, Na Y. New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. Bioorganic & Medicinal Chemistry. 18: 1010-7. PMID 20093033 DOI: 10.1016/j.bmc.2009.12.069 |
0.377 |
|
| 2010 |
Basnet A, Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jahng Y, Na Y, Cho WJ, Kwon Y, Lee CS, Lee ES. 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Bioorganic & Medicinal Chemistry Letters. 20: 42-7. PMID 19954977 DOI: 10.1016/j.bmcl.2009.11.041 |
0.389 |
|
| 2010 |
Thapa P, Karki R, Thapa U, Jahng Y, Jung MJ, Nam JM, Na Y, Kwon Y, Lee ES. 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic & Medicinal Chemistry. 18: 377-86. PMID 19939682 DOI: 10.1016/j.bmc.2009.10.049 |
0.372 |
|
| 2010 |
Sapkota K, Lee E, Yang JH, Kwon Y, Choi J, Na Y. 4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors Bulletin of the Korean Chemical Society. 31: 1319-1325. DOI: 10.5012/Bkcs.2010.31.5.1319 |
0.436 |
|
| 2009 |
Cho HJ, Jung MJ, Kwon Y, Na Y. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6766-9. PMID 19836231 DOI: 10.1016/j.bmcl.2009.09.091 |
0.383 |
|
| 2009 |
Na Y. Recent cancer drug development with xanthone structures. The Journal of Pharmacy and Pharmacology. 61: 707-12. PMID 19505360 DOI: 10.1211/jpp/61.06.0002 |
0.331 |
|
| 2009 |
Kang DH, Jun KY, Lee JP, Pak CS, Na Y, Kwon Y. Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. Journal of Medicinal Chemistry. 52: 3093-7. PMID 19419206 DOI: 10.1021/Jm8014734 |
0.403 |
|
| 2008 |
Kang DH, Kim JS, Jung MJ, Lee ES, Jahng Y, Kwon Y, Na Y. New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 1520-4. PMID 18178085 DOI: 10.1016/j.bmcl.2007.12.053 |
0.38 |
|
| 2008 |
Son JK, Zhao LX, Basnet A, Thapa P, Karki R, Na Y, Jahng Y, Jeong TC, Jeong BS, Lee CS, Lee ES. Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities. European Journal of Medicinal Chemistry. 43: 675-82. PMID 17673337 DOI: 10.1016/j.ejmech.2007.05.002 |
0.356 |
|
| 2008 |
Woo S, Kang DH, Kim J, Lee CS, Lee ES, Jahng Y, Kwon Y, Na Y. Synthesis, cytotoxicity and topoisomerase II inhibition study of new thioxanthone analogues Bulletin of the Korean Chemical Society. 29: 471-474. DOI: 10.5012/Bkcs.2008.29.2.471 |
0.436 |
|
| 2008 |
Rahman AFMM, Dong HK, Jing LL, Lee ES, Na Y, Jun KY, Kwon Y, Jahng Y. Synthesis and Biological Properties of Luotonin a Derivatives Bulletin of the Korean Chemical Society. 29: 1988-1992. DOI: 10.5012/Bkcs.2008.29.10.1988 |
0.385 |
|
| 2007 |
Basnet A, Thapa P, Karki R, Na Y, Jahng Y, Jeong BS, Jeong TC, Lee CS, Lee ES. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorganic & Medicinal Chemistry. 15: 4351-9. PMID 17493824 DOI: 10.1016/j.bmc.2007.04.047 |
0.34 |
|
| 2007 |
Woo S, Jung J, Lee C, Kwon Y, Na Y. Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study. Bioorganic & Medicinal Chemistry Letters. 17: 1163-6. PMID 17194586 DOI: 10.1016/j.bmcl.2006.12.030 |
0.373 |
|
| 2006 |
Kwon Y, Na Y. Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives. Chemical & Pharmaceutical Bulletin. 54: 248-51. PMID 16462076 DOI: 10.1248/Cpb.54.248 |
0.442 |
|
| 2003 |
Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/Ja030452M |
0.551 |
|
| 2003 |
Kim MY, Na Y, Vankayalapati H, Gleason-Guzman M, Hurley LH. Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents. Journal of Medicinal Chemistry. 46: 2958-72. PMID 12825936 DOI: 10.1021/Jm030096I |
0.324 |
|
| 2002 |
Na Y, Wang S, Kohn H. 7-N-(mercaptoalkyl)mitomycins: implications of cyclization for drug function. Journal of the American Chemical Society. 124: 4666-77. PMID 11971715 DOI: 10.1021/Ja0124313 |
0.526 |
|
| 2001 |
Na Y, Li VS, Nakanishi Y, Bastow KF, Kohn H. Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins. Journal of Medicinal Chemistry. 44: 3453-62. PMID 11585450 DOI: 10.1021/Jm010090Y |
0.552 |
|
| 2001 |
Na Y, Kohn H. Quinone-cyclized porfiromycins Heterocycles. 55: 1347-1363. DOI: 10.3987/Com-01-9215 |
0.506 |
|
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