Younghwa Na, Ph.D. - Publications

Affiliations: 
2000 University of Houston, Houston, TX, United States 
Area:
biological mechanisms of therapeutic agents

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Park S, Hong E, Kwak SY, Jun KY, Lee ES, Kwon Y, Na Y. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. European Journal of Medicinal Chemistry. 123: 211-225. PMID 27484510 DOI: 10.1016/j.ejmech.2016.07.046  0.96
2016 Kim JH, Jung YJ, Choi B, Lee NL, Lee HJ, Kwak SY, Kwon Y, Na Y, Lee YS. Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules. Oncotarget. PMID 27449291 DOI: 10.18632/oncotarget.10629  0.96
2016 Jeon KH, Lee E, Jun KY, Eom JE, Kwak SY, Na Y, Kwon Y. Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation. European Journal of Medicinal Chemistry. 121: 433-444. PMID 27318120 DOI: 10.1016/j.ejmech.2016.06.008  0.96
2016 Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents. Bioorganic Chemistry. 66: 145-159. PMID 27174797 DOI: 10.1016/j.bioorg.2016.04.007  0.96
2016 Baek KH, Yu HV, Kim E, Na Y, Kwon Y. Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway. Oncotarget. PMID 27121057 DOI: 10.18632/oncotarget.8791  0.96
2016 Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. European Journal of Medicinal Chemistry. 113: 228-245. PMID 26945111 DOI: 10.1016/j.ejmech.2016.02.050  0.96
2016 Kadayat TM, Park S, Jun KY, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry Letters. PMID 26927425 DOI: 10.1016/j.bmcl.2016.02.053  0.96
2015 Thapa P, Jun KY, Kadayat TM, Park C, Zheng Z, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents. Bioorganic & Medicinal Chemistry. PMID 26361737 DOI: 10.1016/j.bmc.2015.08.018  0.96
2015 Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry. 23: 3499-512. PMID 26022080 DOI: 10.1016/j.bmc.2015.04.031  0.96
2015 Karki R, Song C, Kadayat TM, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines. Bioorganic & Medicinal Chemistry. 23: 3638-54. PMID 25936262 DOI: 10.1016/j.bmc.2015.04.002  0.96
2015 Chae SW, Woo S, Park JH, Kwon Y, Na Y, Lee HJ. Xanthone analogues as potent modulators of intestinal P-glycoprotein. European Journal of Medicinal Chemistry. 93: 237-45. PMID 25686592 DOI: 10.1016/j.ejmech.2015.01.006  0.96
2015 Park SY, Kim MJ, Kim YJ, Lee YH, Bae D, Kim S, Na Y, Yoon HG. Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease. International Journal of Molecular Medicine. 35: 1109-18. PMID 25672970 DOI: 10.3892/ijmm.2015.2099  0.96
2015 Kwon HB, Park C, Jeon KH, Lee E, Park SE, Jun KY, Kadayat TM, Thapa P, Karki R, Na Y, Park MS, Rho SB, Lee ES, Kwon Y. A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. Journal of Medicinal Chemistry. 58: 1100-22. PMID 25603122 DOI: 10.1021/jm501023q  0.96
2014 Jin CH, Jun KY, Lee E, Kim S, Kwon Y, Kim K, Na Y. Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor. Bioorganic & Medicinal Chemistry. 22: 4553-65. PMID 25131958 DOI: 10.1016/j.bmc.2014.07.037  0.96
2013 Baek KH, Karki R, Lee ES, Na Y, Kwon Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorganic Chemistry. 51: 24-30. PMID 24095934 DOI: 10.1016/j.bioorg.2013.09.002  0.96
2013 Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y. 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage. European Journal of Medicinal Chemistry. 69: 139-45. PMID 24013413 DOI: 10.1016/j.ejmech.2013.07.048  0.96
2013 Nam JM, Jeon KH, Kwon H, Lee E, Jun KY, Jin YB, Lee YS, Na Y, Kwon Y. Dithiiranylmethyloxy azaxanthone shows potent anti-tumor activity via suppression of HER2 expression and HER2-mediated signals in HER2-overexpressing breast cancer cells. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 181-90. PMID 23835029 DOI: 10.1016/j.ejps.2013.06.014  0.96
2013 Kim SH, Lee E, Baek KH, Kwon HB, Woo H, Lee ES, Kwon Y, Na Y. Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 23: 3320-4. PMID 23608763 DOI: 10.1016/j.bmcl.2013.03.106  0.96
2012 Kim HL, Jeon KH, Jun KY, Choi Y, Kim DK, Na Y, Kwon Y. A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. Cancer Letters. 325: 72-9. PMID 22732416 DOI: 10.1016/j.canlet.2012.06.004  0.96
2012 Thapa P, Karki R, Yun M, Kadayat TM, Lee E, Kwon HB, Na Y, Cho WJ, Kim ND, Jeong BS, Kwon Y, Lee ES. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety. European Journal of Medicinal Chemistry. 52: 123-36. PMID 22503656 DOI: 10.1016/j.ejmech.2012.03.010  0.96
2012 Thapa P, Karki R, Yoo HY, Park PH, Lee E, Jeon KH, Na Y, Cho WJ, Kwon Y, Lee ES. 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic Chemistry. 40: 67-78. PMID 22000119 DOI: 10.1016/j.bioorg.2011.09.001  0.96
2012 Park HG, Bak EJ, Woo GH, Kim JM, Quan Z, Kim JM, Yoon HK, Cheon SH, Yoon G, Yoo YJ, Na Y, Cha JH. Licochalcone E has an antidiabetic effect. The Journal of Nutritional Biochemistry. 23: 759-67. PMID 21840191 DOI: 10.1016/j.jnutbio.2011.03.021  0.96
2011 Kim MJ, Lee YH, Kwak J, Na Y, Yoon HG. Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage. Bmb Reports. 44: 730-4. PMID 22118539 DOI: 10.5483/BMBRep.2011.44.11.730  0.96
2011 Bak EJ, Park HG, Lee C, Lee TI, Woo GH, Na Y, Yoo YJ, Cha JH. Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro. Bmb Reports. 44: 410-4. PMID 21699755 DOI: 10.5483/BMBRep.2011.44.6.410  0.96
2011 Thapa U, Thapa P, Karki R, Yun M, Choi JH, Jahng Y, Lee E, Jeon KH, Na Y, Ha EM, Cho WJ, Kwon Y, Lee ES. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. European Journal of Medicinal Chemistry. 46: 3201-9. PMID 21601964 DOI: 10.1016/j.ejmech.2011.04.029  0.96
2011 Sapkota K, Roh E, Lee E, Ha EM, Yang JH, Lee ES, Kwon Y, Kim Y, Na Y. Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues. Bioorganic & Medicinal Chemistry. 19: 2168-75. PMID 21429753 DOI: 10.1016/j.bmc.2011.02.044  0.96
2011 Jun KY, Lee EY, Jung MJ, Lee OH, Lee ES, Park Choo HY, Na Y, Kwon Y. Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. European Journal of Medicinal Chemistry. 46: 1964-71. PMID 21419530 DOI: 10.1016/j.ejmech.2011.01.011  0.96
2011 Na Y, Nam JM. Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives. Bioorganic & Medicinal Chemistry Letters. 21: 211-4. PMID 21115246 DOI: 10.1016/j.bmcl.2010.11.037  0.96
2011 Choi KC, Park S, Lim BJ, Seong AR, Sung AR, Lee YH, Shiota M, Yokomizo A, Naito S, Na Y, Yoon HG. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. The Biochemical Journal. 433: 235-44. PMID 20955177 DOI: 10.1042/BJ20100980  0.96
2011 Lee E, Jang I, Shin MJ, Cho HJ, Kim J, Eom JE, Kwon Y, Na Y. Chalcones as novel non-peptidic μ-calpain inhibitors Bulletin of the Korean Chemical Society. 32: 3459-3464. DOI: 10.5012/bkcs.2011.32.9.3459  0.96
2011 Jeong BS, Choi H, Thapa P, Karki R, Lee E, Nam JM, Na Y, Ha EM, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of rigid analogues of 2,4,6-trisubstituted pyridine containing 5,6-dihydrobenzo[h]quinoline moiety Bulletin of the Korean Chemical Society. 32: 303-306. DOI: 10.5012/bkcs.2011.32.1.303  0.96
2010 Woo S, Kang DH, Nam JM, Lee CS, Ha EM, Lee ES, Kwon Y, Na Y. Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. European Journal of Medicinal Chemistry. 45: 4221-8. PMID 20619511 DOI: 10.1016/j.ejmech.2010.06.017  0.96
2010 Karki R, Thapa P, Kang MJ, Jeong TC, Nam JM, Kim HL, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. Bioorganic & Medicinal Chemistry. 18: 3066-77. PMID 20392646 DOI: 10.1016/j.bmc.2010.03.051  0.96
2010 Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jung MJ, Nam JM, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorganic & Medicinal Chemistry. 18: 2245-54. PMID 20188578 DOI: 10.1016/j.bmc.2010.01.065  0.96
2010 Cho HJ, Jung MJ, Woo S, Kim J, Lee ES, Kwon Y, Na Y. New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. Bioorganic & Medicinal Chemistry. 18: 1010-7. PMID 20093033 DOI: 10.1016/j.bmc.2009.12.069  0.96
2010 Basnet A, Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jahng Y, Na Y, Cho WJ, Kwon Y, Lee CS, Lee ES. 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Bioorganic & Medicinal Chemistry Letters. 20: 42-7. PMID 19954977 DOI: 10.1016/j.bmcl.2009.11.041  0.96
2010 Thapa P, Karki R, Thapa U, Jahng Y, Jung MJ, Nam JM, Na Y, Kwon Y, Lee ES. 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic & Medicinal Chemistry. 18: 377-86. PMID 19939682 DOI: 10.1016/j.bmc.2009.10.049  0.96
2010 Sapkota K, Lee E, Yang JH, Kwon Y, Choi J, Na Y. 4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors Bulletin of the Korean Chemical Society. 31: 1319-1325. DOI: 10.5012/bkcs.2010.31.5.1319  0.96
2009 Cho HJ, Jung MJ, Kwon Y, Na Y. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6766-9. PMID 19836231 DOI: 10.1016/j.bmcl.2009.09.091  0.96
2009 Na Y. Recent cancer drug development with xanthone structures. The Journal of Pharmacy and Pharmacology. 61: 707-12. PMID 19505360 DOI: 10.1211/jpp/61.06.0002  0.96
2009 Na Y, Cha JH, Yoon HG, Kwon Y. A concise synthesis of licochalcone E and its regio-isomer, licochalcone F. Chemical & Pharmaceutical Bulletin. 57: 607-9. PMID 19483343 DOI: JST.JSTAGE/cpb/57.607  0.96
2009 Kang DH, Jun KY, Lee JP, Pak CS, Na Y, Kwon Y. Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. Journal of Medicinal Chemistry. 52: 3093-7. PMID 19419206 DOI: 10.1021/jm8014734  0.96
2008 Kang DH, Kim JS, Jung MJ, Lee ES, Jahng Y, Kwon Y, Na Y. New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 1520-4. PMID 18178085 DOI: 10.1016/j.bmcl.2007.12.053  0.96
2008 Son JK, Zhao LX, Basnet A, Thapa P, Karki R, Na Y, Jahng Y, Jeong TC, Jeong BS, Lee CS, Lee ES. Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities. European Journal of Medicinal Chemistry. 43: 675-82. PMID 17673337 DOI: 10.1016/j.ejmech.2007.05.002  0.96
2008 Rahman AFMM, Dong HK, Jing LL, Lee ES, Na Y, Jun KY, Kwon Y, Jahng Y. Synthesis and Biological Properties of Luotonin a Derivatives Bulletin of the Korean Chemical Society. 29: 1988-1992.  0.96
2008 Thapa P, Karki R, Basnet A, Thapa U, Choi H, Na Y, Jahng Y, Lee CS, Kwon Y, Jeong BS, Lee ES. 2,6-Dithienyl-4-arylpyridines: Synthesis, topoisomerase I and II inhibition and structure-activity relationship Bulletin of the Korean Chemical Society. 29: 1605-1608.  0.96
2008 Woo S, Kang DH, Kim J, Lee CS, Lee ES, Jahng Y, Kwon Y, Na Y. Synthesis, cytotoxicity and topoisomerase II inhibition study of new thioxanthone analogues Bulletin of the Korean Chemical Society. 29: 471-474.  0.96
2007 Basnet A, Thapa P, Karki R, Na Y, Jahng Y, Jeong BS, Jeong TC, Lee CS, Lee ES. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorganic & Medicinal Chemistry. 15: 4351-9. PMID 17493824 DOI: 10.1016/j.bmc.2007.04.047  0.96
2007 Na Y. Solvolysis study of cycliciminomitomycins. Chemical & Pharmaceutical Bulletin. 55: 482-7. PMID 17329899 DOI: JST.JSTAGE/cpb/55.482  0.96
2007 Woo S, Jung J, Lee C, Kwon Y, Na Y. Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study. Bioorganic & Medicinal Chemistry Letters. 17: 1163-6. PMID 17194586 DOI: 10.1016/j.bmcl.2006.12.030  0.96
2006 Kwon Y, Na Y. Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives. Chemical & Pharmaceutical Bulletin. 54: 248-51. PMID 16462076 DOI: JST.JSTAGE/cpb/54.248  0.96
2005 Na Y. Synthesis of dihydrofuranoquinophenoxazine analogues as new antitumor agents Bulletin of the Korean Chemical Society. 26: 2047-2050.  0.96
2004 Gao X, Pellois JP, Na Y, Kim Y, Gulari E, Zhou X. High density peptide microarrays. In situ synthesis and applications. Molecular Diversity. 8: 177-87. PMID 15384411 DOI: 10.1023/B:MODI.0000036233.58271.25  0.96
2003 Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/ja030452m  0.96
2003 Kim MY, Na Y, Vankayalapati H, Gleason-Guzman M, Hurley LH. Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents. Journal of Medicinal Chemistry. 46: 2958-72. PMID 12825936 DOI: 10.1021/jm030096i  0.96
2002 Na Y, Wang S, Kohn H. 7-N-(mercaptoalkyl)mitomycins: implications of cyclization for drug function. Journal of the American Chemical Society. 124: 4666-77. PMID 11971715 DOI: 10.1021/ja0124313  0.96
2001 Na Y, Li VS, Nakanishi Y, Bastow KF, Kohn H. Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins. Journal of Medicinal Chemistry. 44: 3453-62. PMID 11585450 DOI: 10.1021/jm010090y  0.96
2001 Na Y, Kohn H. Quinone-cyclized porfiromycins Heterocycles. 55: 1347-1363.  0.96
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