Aneel K. Aggarwal - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Protein-nucleic acid interactions: studied by X-ray crystallography and other biophysical methods
Website:
http://www.mountsinai.org/profiles/aneel-k-aggarwal?id=0000072500001497255792

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Quintana-Feliciano R, Kottur J, Ni M, Ghosh R, Salas-Estrada L, Ahlsen G, Rechkoblit O, Shapiro L, Filizola M, Fang G, Aggarwal AK. Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Nature Communications. 15: 7839. PMID 39244607 DOI: 10.1038/s41467-024-52130-x  0.335
2024 Vu DD, Bonucci A, Brenière M, Cisneros-Aguirre M, Pelupessy P, Wang Z, Carlier L, Bouvignies G, Cortes P, Aggarwal AK, Blackledge M, Gueroui Z, Belle V, Stark JM, Modesti M, et al. Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro. Nature Structural & Molecular Biology. PMID 38898102 DOI: 10.1038/s41594-024-01339-x  0.413
2024 Kottur J, Malik R, Aggarwal AK. Nucleic acid mediated activation of a short prokaryotic Argonaute immune system. Nature Communications. 15: 4852. PMID 38844755 DOI: 10.1038/s41467-024-49271-4  0.317
2024 Malik R, Johnson RE, Ubarretxena-Belandia I, Prakash L, Prakash S, Aggarwal AK. Cryo-EM structure of the Rev1-Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis. Nature Structural & Molecular Biology. PMID 38720088 DOI: 10.1038/s41594-024-01302-w  0.469
2024 Quintana-Feliciano R, Kottur J, Ni M, Ghosh R, Salas-Estrada L, Rechkoblit O, Filizola M, Fang G, Aggarwal AK. epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Biorxiv : the Preprint Server For Biology. PMID 38328099 DOI: 10.1101/2024.01.20.576384  0.388
2024 Rechkoblit O, Sciaky D, Kreitler DF, Buku A, Kottur J, Aggarwal AK. Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology. PMID 38321146 DOI: 10.1038/s41594-024-01220-x  0.325
2023 Kottur J, Malik R, Aggarwal AK. Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System. Biorxiv : the Preprint Server For Biology. PMID 37745538 DOI: 10.1101/2023.09.17.558117  0.349
2023 Vu DD, Bonucci A, Brenière M, Cisneros-Aguirre M, Pelupessy P, Wang Z, Carlier L, Bouvignies G, Cortes P, Aggarwal AK, Blackledge M, Gueroui Z, Belle V, Stark JM, Modesti M, et al. Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates . Biorxiv : the Preprint Server For Biology. PMID 37503201 DOI: 10.1101/2023.07.12.548668  0.409
2023 Tan Y, Yao L, Gamliel A, Nair SJ, Taylor H, Ohgi K, Aggarwal AK, Rosenfeld MG. Signal-induced enhancer activation requires Ku70 to read topoisomerase1-DNA covalent complexes. Nature Structural & Molecular Biology. PMID 36747093 DOI: 10.1038/s41594-022-00883-8  0.332
2022 Malik R, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch. Nature Communications. 13: 1050. PMID 35217661 DOI: 10.1038/s41467-022-28644-7  0.556
2021 Rechkoblit O, Johnson RE, Gupta YK, Prakash L, Prakash S, Aggarwal AK. Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase. Nature Communications. 12: 4020. PMID 34188055 DOI: 10.1038/s41467-021-24317-z  0.513
2021 Rechkoblit O, Johnson RE, Gupta YK, Prakash L, Prakash S, Aggarwal AK. Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase. Nature Communications. 12: 4020. PMID 34188055 DOI: 10.1038/s41467-021-24317-z  0.513
2020 Malik R, Kopylov M, Gomez-Llorente Y, Jain R, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis. Nature Structural & Molecular Biology. PMID 32807989 DOI: 10.1038/S41594-020-0476-7  0.584
2019 Oliveira PH, Ribis JW, Garrett EM, Trzilova D, Kim A, Sekulovic O, Mead EA, Pak T, Zhu S, Deikus G, Touchon M, Lewis-Sandari M, Beckford C, Zeitouni NE, Altman DR, ... ... Aggarwal AK, et al. Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis. Nature Microbiology. PMID 31768029 DOI: 10.1038/S41564-019-0613-4  0.398
2019 Rechkoblit O, Johnson RE, Buku A, Prakash L, Prakash S, Aggarwal AK. Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η. Scientific Reports. 9: 16400. PMID 31704958 DOI: 10.1038/S41598-019-52703-7  0.516
2019 Jain R, Rice WJ, Malik R, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme. Nature Structural & Molecular Biology. 26: 955-962. PMID 31582849 DOI: 10.1038/S41594-019-0305-Z  0.584
2018 Rechkoblit O, Choudhury JR, Buku A, Prakash L, Prakash S, Aggarwal AK. Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine. Scientific Reports. 8: 12702. PMID 30140014 DOI: 10.1038/S41598-018-30796-W  0.562
2018 Tan Y, Jin C, Ma W, Hu Y, Tanasa B, Oh S, Gamliel A, Ma Q, Yao L, Zhang J, Ohgi K, Liu W, Aggarwal AK, Rosenfeld MG. Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program. Molecular Cell. 71: 526-539.e8. PMID 30118678 DOI: 10.1016/J.Molcel.2018.07.039  0.327
2018 Jain R, Aggarwal AK, Rechkoblit O. Eukaryotic DNA polymerases. Current Opinion in Structural Biology. 53: 77-87. PMID 30005324 DOI: 10.1016/J.Sbi.2018.06.003  0.579
2017 Rechkoblit O, Kolbanovskiy A, Landes H, Geacintov NE, Aggarwal AK. Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase. Nature Communications. 8: 965. PMID 29042535 DOI: 10.1038/S41467-017-01013-5  0.501
2017 Charlier C, Bouvignies G, Pelupessy P, Walrant A, Marquant R, Kozlov M, De Ioannes P, Bolik-Coulon N, Sagan S, Cortes P, Aggarwal AK, Carlier L, Ferrage F. Structure and dynamics of an intrinsically disordered protein region that partially folds upon binding by chemical-exchange NMR. Journal of the American Chemical Society. PMID 28780862 DOI: 10.1021/Jacs.7B05823  0.356
2017 Puc J, Aggarwal AK, Rosenfeld MG. Physiological functions of programmed DNA breaks in signal-induced transcription. Nature Reviews. Molecular Cell Biology. PMID 28537575 DOI: 10.1038/Nrm.2017.43  0.533
2017 Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK. Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase. Scientific Reports. 7: 1632. PMID 28487506 DOI: 10.1038/S41598-017-01756-7  0.356
2017 Jain R, Choudhury JR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι. Scientific Reports. 7: 43904. PMID 28272441 DOI: 10.1038/Srep43904  0.534
2016 Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Science Advances. 2: e1601317. PMID 27819052 DOI: 10.1126/Sciadv.1601317  0.61
2016 Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Structures of NS5 Methyltransferase from Zika Virus. Cell Reports. PMID 27633330 DOI: 10.1016/J.Celrep.2016.08.091  0.356
2016 Jain R, Coloma J, García-Sastre A, Aggarwal AK. Structure of the NS3 helicase from Zika virus. Nature Structural & Molecular Biology. PMID 27399257 DOI: 10.1038/Nsmb.3258  0.345
2016 Callahan SJ, Luyten YA, Gupta YK, Wilson GG, Roberts RJ, Morgan RD, Aggarwal AK. Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. Plos Biology. 14: e1002442. PMID 27082731 DOI: 10.1371/Journal.Pbio.1002442  0.5
2016 Coloma J, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase α in binary complex with a DNA:DNA template-primer. Scientific Reports. 6: 23784. PMID 27032819 DOI: 10.1038/Srep23784  0.587
2016 Christie S, Jatiani S, Kuo P, Leshchenko V, Kapoor A, Bisignano P, Aggarwal A, Filizola M, Parekh S. Inhibiting SOX11-DNA Interaction in Mantle Cell Lymphoma Blood. 128: 1840-1840. DOI: 10.1182/Blood.V128.22.1840.1840  0.413
2015 Gupta YK, Chan SH, Xu SY, Aggarwal AK. Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nature Communications. 6: 7363. PMID 26067164 DOI: 10.1038/Ncomms8363  0.567
2015 Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S. An Inhibitor of PIDDosome Formation. Molecular Cell. 58: 767-79. PMID 25936804 DOI: 10.1016/J.Molcel.2015.03.034  0.462
2015 Puc J, Kozbial P, Li W, Tan Y, Liu Z, Suter T, Ohgi KA, Zhang J, Aggarwal AK, Rosenfeld MG. Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell. 160: 367-80. PMID 25619691 DOI: 10.1016/J.Cell.2015.08.044  0.459
2015 Oussenko IA, Gupta YK, Carpio RV, Ramana-Reddy MV, Aggarwal AK, Reddy EP, Holland JF, Ohnuma T. Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib Cancer Research. 75: 694-694. DOI: 10.1158/1538-7445.Am2015-694  0.376
2014 Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Crystal structure of yeast DNA polymerase ε catalytic domain. Plos One. 9: e94835. PMID 24733111 DOI: 10.1371/Journal.Pone.0094835  0.557
2014 Jain R, Vanamee ES, Dzikovski BG, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε. Journal of Molecular Biology. 426: 301-8. PMID 24144619 DOI: 10.1016/J.Jmb.2013.10.015  0.474
2013 Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, Aggarwal AK, Rosenfeld MG. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell. 155: 1581-95. PMID 24360279 DOI: 10.1016/J.Cell.2013.10.056  0.305
2013 Gómez-Llorente Y, Malik R, Jain R, Choudhury JR, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. The architecture of yeast DNA polymerase ζ. Cell Reports. 5: 79-86. PMID 24120860 DOI: 10.1016/J.Celrep.2013.08.046  0.463
2013 Padgaonkar A, Rechkoblit O, Cosenza S, Pallela VR, Drc VS, Reddy MR, Aggarwal A, Reddy EP. Abstract 3239: Discovery and biological characterization of ON108600, a small molecule inhibitor of protein kinase CK2. Cancer Research. 73: 3239-3239. DOI: 10.1158/1538-7445.Am2013-3239  0.335
2012 De Ioannes P, Malu S, Cortes P, Aggarwal AK. Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Reports. 2: 1505-12. PMID 23219551 DOI: 10.1016/J.Celrep.2012.11.004  0.508
2012 Ferrage F, Dutta K, Nistal-Villán E, Patel JR, Sánchez-Aparicio MT, De Ioannes P, Buku A, Aseguinolaza GG, García-Sastre A, Aggarwal AK. Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation. Structure (London, England : 1993). 20: 2048-61. PMID 23063562 DOI: 10.1016/J.Str.2012.09.003  0.388
2012 Ummat A, Rechkoblit O, Jain R, Roy Choudhury J, Johnson RE, Silverstein TD, Buku A, Lone S, Prakash L, Prakash S, Aggarwal AK. Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nature Structural & Molecular Biology. 19: 628-32. PMID 22562137 DOI: 10.1038/Nsmb.2295  0.781
2012 Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK. Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering. Journal of Molecular Biology. 420: 261-8. PMID 22560991 DOI: 10.1016/J.Jmb.2012.04.026  0.394
2012 Malu S, De Ioannes P, Kozlov M, Greene M, Francis D, Hanna M, Pena J, Escalante CR, Kurosawa A, Erdjument-Bromage H, Tempst P, Adachi N, Vezzoni P, Villa A, Aggarwal AK, et al. Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. The Journal of Experimental Medicine. 209: 955-63. PMID 22529269 DOI: 10.1084/Jem.20111437  0.502
2012 Ummat A, Silverstein TD, Jain R, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase η is pre-aligned for dNTP binding and catalysis. Journal of Molecular Biology. 415: 627-34. PMID 22154937 DOI: 10.1016/J.Jmb.2011.11.038  0.791
2012 Xu SY, Nugent RL, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, Wang X, Li Z, Zheng Y, Morgan R. Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579. Journal of Bacteriology. 194: 49-60. PMID 22037402 DOI: 10.1128/Jb.06248-11  0.347
2011 Callahan SJ, Morgan RD, Jain R, Townson SA, Wilson GG, Roberts RJ, Aggarwal AK. Crystallization and preliminary crystallographic analysis of the type IIL restriction enzyme MmeI in complex with DNA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1262-5. PMID 22102043 DOI: 10.1107/S1744309111028041  0.545
2011 De Ioannes P, Escalante CR, Aggarwal AK. Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Research. 39: 7300-7. PMID 21596780 DOI: 10.1093/Nar/Gkr325  0.532
2011 Vasquez-Del Carpio R, Silverstein TD, Lone S, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer. Journal of Molecular Biology. 408: 252-61. PMID 21354175 DOI: 10.1016/J.Jmb.2011.02.042  0.807
2011 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase. Journal of Molecular Biology. 406: 18-28. PMID 21167175 DOI: 10.1016/J.Jmb.2010.12.016  0.518
2011 Vanamee ES, Viadiu H, Chan SH, Ummat A, Hartline AM, Xu SY, Aggarwal AK. Asymmetric DNA recognition by the OkrAI endonuclease, an isoschizomer of BamHI. Nucleic Acids Research. 39: 712-9. PMID 20833632 DOI: 10.1093/Nar/Gkq779  0.831
2010 Silverstein TD, Jain R, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η. Structure (London, England : 1993). 18: 1463-70. PMID 21070945 DOI: 10.1016/J.Str.2010.08.019  0.825
2010 Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 466: 508-12. PMID 20622854 DOI: 10.1038/Nature09272  0.327
2010 Silverstein TD, Johnson RE, Jain R, Prakash L, Prakash S, Aggarwal AK. Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature. 465: 1039-43. PMID 20577207 DOI: 10.1038/Nature09104  0.834
2010 Nistal-Villán E, Gack MU, Martínez-Delgado G, Maharaj NP, Inn KS, Yang H, Wang R, Aggarwal AK, Jung JU, García-Sastre A. Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production. The Journal of Biological Chemistry. 285: 20252-61. PMID 20406818 DOI: 10.1074/Jbc.M109.089912  0.31
2009 Jain R, Hammel M, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural insights into yeast DNA polymerase delta by small angle X-ray scattering. Journal of Molecular Biology. 394: 377-82. PMID 19818796 DOI: 10.1016/J.Jmb.2009.09.066  0.425
2009 Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta. Nature Structural & Molecular Biology. 16: 979-86. PMID 19718023 DOI: 10.1038/Nsmb.1663  0.599
2009 Jain R, Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Replication across template T/U by human DNA polymerase-iota. Structure (London, England : 1993). 17: 974-80. PMID 19604477 DOI: 10.1016/J.Str.2009.04.011  0.44
2009 Vasquez-Del Carpio R, Silverstein TD, Lone S, Swan MK, Choudhury JR, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. Plos One. 4: e5766. PMID 19492058 DOI: 10.1371/Journal.Pone.0005766  0.837
2009 Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structure of the human Rev1-DNA-dNTP ternary complex. Journal of Molecular Biology. 390: 699-709. PMID 19464298 DOI: 10.1016/J.Jmb.2009.05.026  0.606
2009 Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK. Co-occupancy of two Pumilio molecules on a single hunchback NRE. Rna (New York, N.Y.). 15: 1029-35. PMID 19372537 DOI: 10.1261/Rna.1327609  0.39
2009 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. DNA synthesis across an abasic lesion by human DNA polymerase iota. Structure (London, England : 1993). 17: 530-7. PMID 19368886 DOI: 10.1016/J.Str.2009.02.015  0.525
2009 Hwang Y, Aggarwal AK, Vanamee ES, Samso M. Structure of a Type III Restriction Endonuclease by Single-Particle Electron Microscopy Biophysical Journal. 96: 412a. DOI: 10.1016/J.Bpj.2008.12.2102  0.322
2008 Gupta YK, Nair DT, Wharton RP, Aggarwal AK. Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure (London, England : 1993). 16: 549-57. PMID 18328718 DOI: 10.1016/J.Str.2008.01.006  0.421
2008 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Structure (London, England : 1993). 16: 239-45. PMID 18275815 DOI: 10.1016/J.Str.2007.12.009  0.564
2007 Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 131: 530-43. PMID 17981120 DOI: 10.1016/J.Cell.2007.09.024  0.577
2007 Escalante CR, Nistal-Villán E, Shen L, García-Sastre A, Aggarwal AK. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Molecular Cell. 26: 703-16. PMID 17560375 DOI: 10.1016/J.Molcel.2007.04.022  0.436
2007 Vanamee ES, Berriman J, Aggarwal AK. An EM view of the FokI synaptic complex by single particle analysis. Journal of Molecular Biology. 370: 207-12. PMID 17524420 DOI: 10.1016/J.Jmb.2007.04.066  0.413
2007 Townson SA, Samuelson JC, Bao Y, Xu SY, Aggarwal AK. BstYI bound to noncognate DNA reveals a "hemispecific" complex: implications for DNA scanning. Structure (London, England : 1993). 15: 449-59. PMID 17437717 DOI: 10.1016/J.Str.2007.03.002  0.599
2007 Niv MY, Ripoll DR, Vila JA, Liwo A, Vanamee ES, Aggarwal AK, Weinstein H, Scheraga HA. Topology of Type II REases revisited; structural classes and the common conserved core. Nucleic Acids Research. 35: 2227-37. PMID 17369272 DOI: 10.1093/Nar/Gkm045  0.367
2007 Lone S, Townson SA, Uljon SN, Johnson RE, Brahma A, Nair DT, Prakash S, Prakash L, Aggarwal AK. Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Molecular Cell. 25: 601-14. PMID 17317631 DOI: 10.1016/J.Molcel.2007.01.018  0.81
2006 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nature Structural & Molecular Biology. 13: 619-25. PMID 16819516 DOI: 10.1038/Nsmb1118  0.525
2006 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure (London, England : 1993). 14: 749-55. PMID 16615915 DOI: 10.1016/J.Str.2006.01.010  0.605
2006 Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. Journal of Molecular Biology. 356: 1065-72. PMID 16405996 DOI: 10.1016/J.Jmb.2005.12.004  0.357
2005 Vanamee ES, Viadiu H, Kucera R, Dorner L, Picone S, Schildkraut I, Aggarwal AK. A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA. The Embo Journal. 24: 4198-208. PMID 16308566 DOI: 10.1038/Sj.Emboj.7600880  0.578
2005 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Structure (London, England : 1993). 13: 1569-77. PMID 16216587 DOI: 10.1016/J.Str.2005.08.010  0.522
2005 Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ. Proximity-induced activation of human Cdc34 through heterologous dimerization. Proceedings of the National Academy of Sciences of the United States of America. 102: 15053-8. PMID 16210246 DOI: 10.1073/Pnas.0507646102  0.336
2005 Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science (New York, N.Y.). 309: 2219-22. PMID 16195463 DOI: 10.1126/Science.1116336  0.533
2005 Townson SA, Samuelson JC, Xu SY, Aggarwal AK. Implications for switching restriction enzyme specificities from the structure of BstYI bound to a BglII DNA sequence. Structure (London, England : 1993). 13: 791-801. PMID 15893669 DOI: 10.1016/J.Str.2005.02.018  0.583
2005 Aggarwal AK, Nair DT, Trincao J, Uljon SN, Johnson RE, Escalante CR, Edwards TA, Prakash S, Prakash L. Eukaryotic translesion synthesis DNA polymerases: structure and function Acta Crystallographica Section a Foundations of Crystallography. 61: c59-c59. DOI: 10.1107/S0108767305097503  0.769
2005 Aggarwal A, Nair D, Johnson R, Prakash L, Prakash S. Hoogsteen base-pairing in DNA replication? (reply) Nature. 437: E7-E7. DOI: 10.1038/Nature04200  0.497
2004 Yoon-Robarts M, Blouin AG, Bleker S, Kleinschmidt JA, Aggarwal AK, Escalante CR, Linden RM. Residues within the B' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2. The Journal of Biological Chemistry. 279: 50472-81. PMID 15371437 DOI: 10.1074/Jbc.M403900200  0.564
2004 James JA, Aggarwal AK, Linden RM, Escalante CR. Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12455-60. PMID 15310852 DOI: 10.1073/Pnas.0403454101  0.616
2004 Uljon SN, Johnson RE, Edwards TA, Prakash S, Prakash L, Aggarwal AK. Crystal structure of the catalytic core of human DNA polymerase kappa. Structure (London, England : 1993). 12: 1395-404. PMID 15296733 DOI: 10.1016/J.Str.2004.05.011  0.801
2004 Nair DT, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature. 430: 377-80. PMID 15254543 DOI: 10.1038/Nature02692  0.565
2004 Townson SA, Samuelson JC, Vanamee ES, Edwards TA, Escalante CR, Xu SY, Aggarwal AK. Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII. Journal of Molecular Biology. 338: 725-33. PMID 15099740 DOI: 10.1016/J.Jmb.2004.02.074  0.518
2004 Trincao J, Johnson RE, Wolfle WT, Escalante CR, Prakash S, Prakash L, Aggarwal AK. Dpo4 is hindered in extending a G.T mismatch by a reverse wobble. Nature Structural & Molecular Biology. 11: 457-62. PMID 15077104 DOI: 10.1038/Nsmb755  0.74
2003 Vanamee ES, Hsieh Pc, Zhu Z, Yates D, Garman E, Xu Sy, Aggarwal AK. Glucocorticoid receptor-like Zn(Cys)4 motifs in BslI restriction endonuclease. Journal of Molecular Biology. 334: 595-603. PMID 14623197 DOI: 10.1016/J.Jmb.2003.09.043  0.395
2003 Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK. Model of the brain tumor-Pumilio translation repressor complex. Genes & Development. 17: 2508-13. PMID 14561773 DOI: 10.1101/Gad.1119403  0.347
2003 James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK. Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure (London, England : 1993). 11: 1025-35. PMID 12906833 DOI: 10.1016/S0969-2126(03)00152-7  0.712
2003 Viadiu H, Vanamee ES, Jacobson EM, Schildkraut I, Aggarwal AK. Crystallization of restriction endonuclease SfiI in complex with DNA. Acta Crystallographica. Section D, Biological Crystallography. 59: 1493-5. PMID 12876363 DOI: 10.1107/S0907444903011910  0.461
2003 Green JB, Gardner CD, Wharton RP, Aggarwal AK. RNA recognition via the SAM domain of Smaug. Molecular Cell. 11: 1537-48. PMID 12820967 DOI: 10.1016/S1097-2765(03)00178-3  0.369
2003 Sun J, Viadiu H, Aggarwal AK, Weinstein H. Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex. Biophysical Journal. 84: 3317-25. PMID 12719261 DOI: 10.1016/S0006-3495(03)70056-3  0.562
2003 Johnson RE, Trincao J, Aggarwal AK, Prakash S, Prakash L. Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases. Molecular and Cellular Biology. 23: 3008-12. PMID 12665597 DOI: 10.1128/Mcb.23.8.3008-3012.2003  0.8
2002 Escalante CR, Brass AL, Pongubala JM, Shatova E, Shen L, Singh H, Aggarwal AK. Crystal structure of PU.1/IRF-4/DNA ternary complex. Molecular Cell. 10: 1097-105. PMID 12453417 DOI: 10.1016/S1097-2765(02)00703-7  0.569
2002 Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK. Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Molecular Cell. 10: 857-69. PMID 12419229 DOI: 10.1016/S1097-2765(02)00650-0  0.379
2002 Dean KA, Aggarwal AK, Wharton RP. Translational repressors in Drosophila. Trends in Genetics : Tig. 18: 572-7. PMID 12414187 DOI: 10.1016/S0168-9525(02)02792-0  0.313
2002 Green JB, Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK. Crystallization and characterization of Smaug: a novel RNA-binding motif. Biochemical and Biophysical Research Communications. 297: 1085-8. PMID 12372396 DOI: 10.1016/S0006-291X(02)02327-6  0.722
2002 Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK. Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. Journal of Structural Biology. 139: 55-9. PMID 12372320 DOI: 10.1016/S1047-8477(02)00514-2  0.447
2002 Escalante CR, Shen L, Thanos D, Aggarwal AK. Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter. Structure (London, England : 1993). 10: 383-91. PMID 12005436 DOI: 10.1016/S0969-2126(02)00723-2  0.392
2001 Trincao J, Johnson RE, Escalante CR, Prakash S, Prakash L, Aggarwal AK. Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Molecular Cell. 8: 417-26. PMID 11545743 DOI: 10.1016/S1097-2765(01)00306-9  0.821
2001 Vanamee ES, Santagata S, Aggarwal AK. FokI requires two specific DNA sites for cleavage. Journal of Molecular Biology. 309: 69-78. PMID 11491302 DOI: 10.1006/Jmbi.2001.4635  0.517
2001 Edwards TA, Pyle SE, Wharton RP, Aggarwal AK. Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell. 105: 281-9. PMID 11336677 DOI: 10.1016/S0092-8674(01)00318-X  0.363
2001 Yoon M, Smith DH, Ward P, Medrano FJ, Aggarwal AK, Linden RM. Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro. Journal of Virology. 75: 3230-9. PMID 11238849 DOI: 10.1128/Jvi.75.7.3230-3239.2001  0.447
2001 Lukacs CM, Aggarwal AK. BglII and MunI: What a difference a base makes Current Opinion in Structural Biology. 11: 14-18. PMID 11179886 DOI: 10.1016/S0959-440X(00)00174-3  0.575
2001 Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK. Structure of free BglII reveals an unprecedented scissor-like motion for opening an endonuclease Nature Structural Biology. 8: 126-130. PMID 11175900 DOI: 10.1038/84111  0.561
2000 Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK. Crystallization and characterization of Pumilo: a novel RNA binding protein. Journal of Structural Biology. 132: 251-4. PMID 11303521 DOI: 10.1006/Jsbi.2000.4319  0.725
2000 Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carrière C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science (New York, N.Y.). 290: 1127-31. PMID 11073444 DOI: 10.1126/Science.290.5494.1127  0.364
2000 Viadiu H, Aggarwal AK. Structure of BamHI bound to nonspecific DNA: A model for DNA sliding Molecular Cell. 5: 889-895. PMID 10882125 DOI: 10.1016/S1097-2765(00)80329-9  0.583
2000 Qiu L, Escalante CR, Aggarwal AK, Wilson PD, Burrow CR. Monomeric midkine induces tumor cell proliferation in the absence of cell-surface proteoglycan binding. Biochemistry. 39: 5977-87. PMID 10821669 DOI: 10.1021/Bi991519E  0.308
2000 Viadiu H, Kucera R, Schildkraut I, Aggarwal AK. Crystallization of restriction endonuclease BamHI with nonspecific DNA Journal of Structural Biology. 130: 81-85. PMID 10806094 DOI: 10.1006/Jsbi.2000.4235  0.509
2000 Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK. Understanding the immutability of restriction enzymes: Crystal structure of Bg/II and its DNA substrate at 1.5 Å resolution Nature Structural Biology. 7: 134-140. PMID 10655616 DOI: 10.1038/72405  0.589
1999 Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG. Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell. 97: 587-98. PMID 10367888 DOI: 10.1016/S0092-8674(00)80770-9  0.381
1999 Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 399: 491-6. PMID 10365964 DOI: 10.1038/20974  0.339
1999 Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature. 397: 714-9. PMID 10067897 DOI: 10.1038/17833  0.547
1998 Viadiu H, Aggarwal AK. The role of metals in catalysis by the restriction endonuclease bamhi Nature Structural Biology. 5: 910-916. PMID 9783752 DOI: 10.1038/2352  0.48
1998 Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG. Signal-specific co-activator domain requirements for Pit-1 activation. Nature. 395: 301-6. PMID 9751061 DOI: 10.1038/26270  0.366
1998 Bitinaite J, Wah DA, Aggarwal AK, Schildkraut I. Foki dimerization is required for dna cleavage Proceedings of the National Academy of Sciences of the United States of America. 95: 10570-10575. PMID 9724744 DOI: 10.1073/Pnas.95.18.10570  0.552
1998 Wah DA, Bitinaite J, Schildkraut I, Aggarwal AK. Structure of FokI has implications for DNA cleavage Proceedings of the National Academy of Sciences of the United States of America. 95: 10564-10569. PMID 9724743 DOI: 10.1073/Pnas.95.18.10564  0.584
1998 Aggarwal AK, Wah DA. Novel site-specific DNA endonucleases Current Opinion in Structural Biology. 8: 19-25. PMID 9519292 DOI: 10.1016/S0959-440X(98)80005-5  0.534
1998 Escalante CR, Yie J, Thanos D, Aggarwal AK. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation Nature. 391: 103-106. PMID 9422515 DOI: 10.1038/34224  0.529
1997 Escalante CR, Yie J, Thanos D, Aggarwal AK. Expression, purification, and co-crystallization of IRF-I bound to the interferon-β element PRDI Febs Letters. 414: 219-220. PMID 9315689 DOI: 10.1016/S0014-5793(97)00996-4  0.441
1997 Wah DA, Hirsch JA, Dorner LF, Schildkraut I, Aggarwal AK. Structure of the multimodular endonuclease FokI bound to DNA Nature. 388: 97-100. PMID 9214510 DOI: 10.1038/40446  0.557
1997 Aggarwal AK. Homing in on intron-encoded endonucleases Nature Structural Biology. 4: 423-424. PMID 9187644 DOI: 10.1038/Nsb0697-423  0.493
1997 Hirsch JA, Wah DA, Dorner LF, Schildkraut I, Aggarwal AK. Crystallization and preliminary X-ray analysis of restriction endonuclease FokI bound to DNA Febs Letters. 403: 136-138. PMID 9042953 DOI: 10.1016/S0014-5793(97)00039-2  0.544
1997 Jacobson EM, Li P, Leon-del-Rio A, Rosenfeld MG, Aggarwal AK. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes & Development. 11: 198-212. PMID 9009203 DOI: 10.1101/Gad.11.2.198  0.544
1996 Jacobson EM, Li P, Rosenfeld MG, Aggarwal AK. Crystallization and preliminary X-ray analysis of Pit-1 POU domain complexed to a 28 base pair DNA element. Proteins. 24: 263-5. PMID 8820493 DOI: 10.1002/(Sici)1097-0134(199602)24:2<263::Aid-Prot14>3.0.Co;2-L  0.449
1995 Hirsch JA, Aggarwal AK. Structure of the Even-skipped homeodomain complexed to AT-rich DNA: New perspectives on homeodomain specificity Embo Journal. 14: 6280-6291. PMID 8557047 DOI: 10.1002/J.1460-2075.1995.Tb00318.X  0.583
1995 Hirsch JA, Aggarwal AK. Purification, crystallization, and preliminary X-ray diffraction analysis of even-skipped homeodomain complexed to DNA Proteins: Structure, Function and Genetics. 21: 268-271. PMID 7784431 DOI: 10.1002/Prot.340210311  0.391
1995 Aggarwal AK. A gripping end to NF-κB Nature Structural Biology. 2: 184-186. PMID 7773784 DOI: 10.1038/Nsb0395-184  0.469
1995 Aggarwal AK. Structure and function of restriction endonucleases Current Opinion in Structural Biology. 5: 11-19. PMID 7773740 DOI: 10.1016/0959-440X(95)80004-K  0.462
1995 Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of Bam HI endonuclease bound to DNA: Partial folding and unfolding on DNA binding Science. 269: 656-663. PMID 7624794 DOI: 10.1126/Science.7624794  0.59
1994 Strzelecka T, Newman M, Dorner LF, Knott R, Schildkraut I, Aggarwal AK. Crystallization and preliminary X-ray analysis of restriction endonuclease BamHI-DNA complex. Journal of Molecular Biology. 239: 430-2. PMID 8201623 DOI: 10.1006/Jmbi.1994.1383  0.488
1994 Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of restriction endonuclease BamHI and its relationship to EcoRI. Nature. 368: 660-4. PMID 8145855 DOI: 10.1038/368660A0  0.448
1994 Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of restriction endonuclease bamhi phased at 1.95 A resolution by MAD analysis. Structure (London, England : 1993). 2: 439-52. PMID 8081758 DOI: 10.1016/S0969-2126(00)00045-9  0.528
1993 Li P, He X, Gerrero MR, Mok M, Aggarwal A, Rosenfeld MG. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes & Development. 7: 2483-96. PMID 8276233 DOI: 10.1101/Gad.7.12B.2483  0.503
1990 Aggarwal AK. Crystallization of DNA binding proteins with oligodeoxynucleotides. Methods (San Diego, Calif.). 1: 83-90. PMID 34167191 DOI: 10.1016/S1046-2023(05)80150-1  0.463
1990 Aggarwal AK. Crystallization of DNA binding proteins with oligodeoxynucleotides. Methods (San Diego, Calif.). 1: 83-90. PMID 34167191 DOI: 10.1016/S1046-2023(05)80150-1  0.463
1990 Aggarwal AK, Islam SA, Neidle S. Computer modelling studies of the covalent interactions between DNA and the enantiomers of anti-7,8-diol,9,10-epoxy-benzo[a]pyrene. Journal of Biomolecular Structure & Dynamics. 1: 873-81. PMID 6443878 DOI: 10.1080/07391102.1983.10507490  0.626
1990 Pabo CO, Aggarwal AK, Jordan SR, Beamer LJ, Obeysekare UR, Harrison SC. Conserved residues make similar contacts in two repressor-operator complexes. Science (New York, N.Y.). 247: 1210-3. PMID 2315694 DOI: 10.1126/Science.2315694  0.354
1990 Harrison SC, Aggarwal AK. DNA recognition by proteins with the helix-turn-helix motif. Annual Review of Biochemistry. 59: 933-69. PMID 2197994 DOI: 10.1146/Annurev.Bi.59.070190.004441  0.552
1990 Aggarwal AK. Crystallization of DNA binding proteins with oligodeoxynucleotides Methods. 1: 83-90. DOI: 10.1016/S1046-2023(05)80150-1  0.548
1988 Aggarwal AK, Rodgers DW, Drottar M, Ptashne M, Harrison SC. Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science (New York, N.Y.). 242: 899-907. PMID 3187531 DOI: 10.1126/Science.3187531  0.538
1985 Bales JR, Mazid MA, Sadler PJ, Aggarwal A, Kuroda R, Neidle S, Gilmour DW, Peart BJ, Ramsden CA. Platinum(II) complexes of nitroimidazoles: synthesis, characterisation, and X-ray crystal structures of cis-dichlorobis[1-(2′-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole]platinum(II) and trans-dichlorobis[1-(2′-hydroxy-3′-methoxypropyl)-2-nitroimidazole]platinum(II) Journal of the Chemical Society-Dalton Transactions. 795-802. DOI: 10.1039/Dt9850000795  0.474
1985 BALES JR, MAZID MA, SADLER PJ, AGGARWAL A, KURODA R, NEIDLE S, GILMOUR DW, PEART BJ, RAMSDEN CA. ChemInform Abstract: PLATINUM(II) COMPLEXES OF NITROIMIDAZOLES: SYNTHESIS, CHARACTERIZATION, AND X-RAY CRYSTAL STRUCTURES OF CIS-DICHLOROBIS(1-(2′-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE)PLATINUM(II) AND TRANS-DICHLOROBIS(1-(2′-HYDROXY-3′-METHOXYPR Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198532336  0.4
1984 Aggarwal A, Islam SA, Kuroda R, Neidle S. X-ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG. Biopolymers. 23: 1025-41. PMID 6733246 DOI: 10.1002/Bip.360230605  0.529
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