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Emad Saleem Alnemri - Publications

Genetics Thomas Jefferson University 
Cell Biology, Biochemistry, Immunology

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Rogers C, Erkes DA, Nardone A, Aplin AE, Fernandes-Alnemri T, Alnemri ES. Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nature Communications. 10: 1689. PMID 30976076 DOI: 10.1038/s41467-019-09397-2  0.72
2018 Barry R, John SW, Liccardi G, Tenev T, Jaco I, Chen CH, Choi J, Kasperkiewicz P, Fernandes-Alnemri T, Alnemri E, Drag M, Chen Y, Meier P. SUMO-mediated regulation of NLRP3 modulates inflammasome activity. Nature Communications. 9: 3001. PMID 30069026 DOI: 10.1038/s41467-018-05321-2  0.72
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/s41418-017-0012-4  0.32
2017 Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nature Communications. 8: 14128. PMID 28045099 DOI: 10.1038/ncomms14128  0.72
2015 Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nature Communications. 6: 7515. PMID 26104484 DOI: 10.1038/ncomms8515  0.4
2015 Hwang I, Yang J, Hong S, Ju Lee E, Lee SH, Fernandes-Alnemri T, Alnemri ES, Yu JW. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4. Immunology and Cell Biology. 93: 591-9. PMID 25601272 DOI: 10.1038/icb.2014.125  0.4
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/cdd.2014.137  0.4
2014 Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, et al. IKKα negatively regulates ASC-dependent inflammasome activation. Nature Communications. 5: 4977. PMID 25266676 DOI: 10.1038/ncomms5977  0.4
2014 Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. Biochimica Et Biophysica Acta. 1843: 1295-307. PMID 24709290 DOI: 10.1016/j.bbamcr.2014.03.027  0.4
2014 Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MD. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. Journal of Immunology (Baltimore, Md. : 1950). 192: 3881-8. PMID 24623131 DOI: 10.4049/jimmunol.1301974  0.72
2013 Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW, Alnemri ES. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. Journal of Immunology (Baltimore, Md. : 1950). 191: 4358-66. PMID 24048902 DOI: 10.4049/jimmunol.1301170  0.72
2013 Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. Journal of Immunology (Baltimore, Md. : 1950). 191: 3995-9. PMID 24043892 DOI: 10.4049/jimmunol.1301681  0.4
2013 Yu JW, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES. Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome. The Journal of Biological Chemistry. 288: 11378-83. PMID 23479736 DOI: 10.1074/jbc.M112.448795  0.72
2013 Hong S, Hwang I, Lee YS, Park S, Lee WK, Fernandes-Alnemri T, Alnemri ES, Kim YS, Yu JW. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death. Cancer Letters. 331: 183-91. PMID 23321501 DOI: 10.1016/j.canlet.2012.12.020  0.72
2013 Kang S, Fernandes-Alnemri T, Alnemri ES. A novel role for the mitochondrial HTRA2/OMI protease in aging. Autophagy. 9: 420-1. PMID 23242108 DOI: 10.4161/auto.22920  0.72
2013 Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging. Cell Death and Differentiation. 20: 259-69. PMID 22976834 DOI: 10.1038/cdd.2012.117  0.72
2012 Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. The Journal of Biological Chemistry. 287: 36617-22. PMID 22948162 DOI: 10.1074/jbc.M112.407130  0.72
2012 Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation. 19: 107-20. PMID 21760595 DOI: 10.1038/cdd.2011.96  0.4
2011 Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. Journal of Immunology (Baltimore, Md. : 1950). 187: 4890-9. PMID 21957143 DOI: 10.4049/jimmunol.1100381  0.72
2010 Ulland TK, Buchan BW, Ketterer MR, Fernandes-Alnemri T, Meyerholz DK, Apicella MA, Alnemri ES, Jones BD, Nauseef WM, Sutterwala FS. Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. Journal of Immunology (Baltimore, Md. : 1950). 185: 2670-4. PMID 20679532 DOI: 10.4049/jimmunol.1001610  0.4
2010 Wu J, Fernandes-Alnemri T, Alnemri ES. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. Journal of Clinical Immunology. 30: 693-702. PMID 20490635 DOI: 10.1007/s10875-010-9425-2  0.72
2010 Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP, Alnemri ES. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nature Immunology. 11: 385-93. PMID 20351693 DOI: 10.1038/ni.1859  0.72
2010 Jéru I, Marlin S, Le Borgne G, Cochet E, Normand S, Duquesnoy P, Dastot-Le Moal F, Cuisset L, Hentgen V, Fernandes Alnemri T, Lecron JC, Dhote R, Grateau G, Alnemri ES, Amselem S. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 identified in an atypical autoinflammatory disorder. Arthritis and Rheumatism. 62: 1176-85. PMID 20131254 DOI: 10.1002/art.27326  0.4
2010 Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. The Journal of Biological Chemistry. 285: 9792-802. PMID 20093358 DOI: 10.1074/jbc.M109.082305  0.4
2009 Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. Journal of Immunology (Baltimore, Md. : 1950). 183: 787-91. PMID 19570822 DOI: 10.4049/jimmunol.0901363  0.72
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/cdd.2009.44  0.4
2009 Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 458: 509-13. PMID 19158676 DOI: 10.1038/nature07710  0.72
2009 Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death and Differentiation. 16: 3-11. PMID 18846107 DOI: 10.1038/cdd.2008.150  0.4
2008 Fernandes-Alnemri T, Alnemri ES. Assembly, purification, and assay of the activity of the ASC pyroptosome. Methods in Enzymology. 442: 251-70. PMID 18662574 DOI: 10.1016/S0076-6879(08)01413-4  0.72
2008 Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, et al. The NLR gene family: a standard nomenclature. Immunity. 28: 285-7. PMID 18341998 DOI: 10.1016/j.immuni.2008.02.005  0.4
2008 Khan FS, Fujioka M, Datta P, Fernandes-Alnemri T, Jaynes JB, Alnemri ES. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death and Differentiation. 15: 1073-83. PMID 18259196 DOI: 10.1038/cdd.2008.19  0.4
2007 Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Molecular Cell. 28: 214-27. PMID 17964261 DOI: 10.1016/j.molcel.2007.08.029  0.72
2007 Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death and Differentiation. 14: 1590-604. PMID 17599095 DOI: 10.1038/sj.cdd.4402194  0.4
2006 Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, Alnemri ES. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death and Differentiation. 13: 236-49. PMID 16037825 DOI: 10.1038/sj.cdd.4401734  0.72
2004 Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, Dubois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity. The Journal of Biological Chemistry. 279: 45844-54. PMID 15294909 DOI: 10.1074/jbc.M404940200  0.4
2004 Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 429: 75-9. PMID 15129283 DOI: 10.1038/nature02451  0.4
2004 Guo Y, Cheong N, Zhang Z, De Rose R, Deng Y, Farber SA, Fernandes-Alnemri T, Alnemri ES. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. The Journal of Biological Chemistry. 279: 24813-25. PMID 15044455 DOI: 10.1074/jbc.M402049200  0.4
2003 Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721-7. PMID 14534547 DOI: 10.1038/nature02052  0.4
2003 Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. The Journal of Biological Chemistry. 278: 38699-706. PMID 12865429 DOI: 10.1074/jbc.M303179200  0.72
2003 Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES. Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. The Journal of Biological Chemistry. 278: 31469-72. PMID 12835328 DOI: 10.1074/jbc.C300240200  0.72
2003 Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Research. 63: 1712-21. PMID 12670926  0.4
2003 Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES, Newland AC. Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene. 22: 1589-99. PMID 12642862 DOI: 10.1038/sj.onc.1206322  0.4
2003 Chang DW, Ditsworth D, Liu H, Srinivasula SM, Alnemri ES, Yang X. Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. The Journal of Biological Chemistry. 278: 16466-9. PMID 12637514 DOI: 10.1074/jbc.C300089200  0.4
2003 Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y. Mechanism of XIAP-mediated inhibition of caspase-9. Molecular Cell. 11: 519-27. PMID 12620238 DOI: 10.1016/S1097-2765(03)00054-6  0.4
2002 Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nature Structural Biology. 9: 436-41. PMID 11967569 DOI: 10.1038/nsb795  0.4
2002 Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. The Journal of Biological Chemistry. 277: 21119-22. PMID 11967258 DOI: 10.1074/jbc.C200179200  0.4
2002 Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. The Journal of Biological Chemistry. 277: 13430-7. PMID 11832478 DOI: 10.1074/jbc.M108029200  0.72
2002 Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. The Journal of Biological Chemistry. 277: 13952-8. PMID 11821383 DOI: 10.1074/jbc.M107811200  0.4
2002 Srinivasula SM, Datta P, Kobayashi M, Wu JW, Fujioka M, Hegde R, Zhang Z, Mukattash R, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Current Biology : Cb. 12: 125-30. PMID 11818063 DOI: 10.1016/S0960-9822(01)00657-1  0.4
2002 van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, Alnemri ES, Gevaert K, Vandekerckhove J, Declercq W, Vandenabeele P. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity Cell Death and Differentiation. 9: 20-26. PMID 11803371 DOI: 10.1038/sj.cdd.4400970  0.4
2002 Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnóczky G. Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. The Journal of Biological Chemistry. 277: 5651-9. PMID 11741882 DOI: 10.1074/jbc.M108171200  0.4
2002 Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. The Journal of Biological Chemistry. 277: 432-8. PMID 11606597 DOI: 10.1074/jbc.M109721200  0.72
2001 Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y. Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell. 107: 399-407. PMID 11701129 DOI: 10.1016/S0092-8674(01)00544-X  0.4
2001 Partheniou F, Kelsey SM, Srinivasula SM, Newland AC, Alnemri ES, Jia L. c-IAP1 Blocks TNFα-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells Biochemical and Biophysical Research Communications. 287: 181-189. PMID 11549272 DOI: 10.1006/bbrc.2001.5582  0.4
2001 Druilhe A, Srinivasula SM, Razmara M, Ahmad M, Alnemri ES. Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins Cell Death and Differentiation. 8: 649-657. PMID 11536016 DOI: 10.1038/sj.cdd.4400881  0.4
2001 Jia L, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM. Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Oncogene. 20: 4817-26. PMID 11521193 DOI: 10.1038/sj.onc.1204628  0.4
2001 Jia L, Srinivasula SM, Liu FT, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM. Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells Blood. 98: 414-421. PMID 11435311 DOI: 10.1182/blood.V98.2.414  0.4
2001 Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES. Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1 Journal of Biological Chemistry. 276: 28309-28313. PMID 11390368 DOI: 10.1074/jbc.C100250200  0.4
2001 Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. The Journal of Biological Chemistry. 276: 11877-82. PMID 11278692 DOI: 10.1074/jbc.M010512200  0.4
2001 Patriotis C, Russeva MG, Lin JH, Srinivasula SM, Markova DZ, Tsatsanis C, Makris A, Alnemri ES, Tsichlis PN. Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3 Journal of Cellular Physiology. 187: 176-187. PMID 11267997 DOI: 10.1002/jcp.1066  0.4
2001 Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. The Journal of Biological Chemistry. 276: 21405-9. PMID 11259443 DOI: 10.1074/jbc.M102488200  0.4
2001 Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Dataa P. Structural basis of caspase-7 inhibition by XIAP. Cell. 104: 769-80. PMID 11257230  0.4
2001 Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 410: 112-6. PMID 11242052 DOI: 10.1038/35065125  0.4
2001 Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES, Cohen GM. Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes Embo Journal. 20: 998-1009. PMID 11230124 DOI: 10.1093/emboj/20.5.998  0.4
2000 Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. The Journal of Biological Chemistry. 275: 41082-6. PMID 11053425 DOI: 10.1074/jbc.C000726200  0.4
2000 Poyet JL, Srinivasula SM, Lin JH, Fernandes-Alnemri T, Yamaoka S, Tsichlis PN, Alnemri ES. Activation of the IκB kinases by RIP via IKKγ/NEMO-mediated oligomerization Journal of Biological Chemistry. 275: 37966-37977. PMID 10980203 DOI: 10.1074/jbc.M006643200  0.4
2000 Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. The Journal of Biological Chemistry. 275: 36152-7. PMID 10950947 DOI: 10.1074/jbc.C000533200  0.72
2000 Truneh A, Sharma S, Silverman C, Khandekar S, Reddy MP, Deen KC, McLaughlin MM, Srinivasula SM, Livi GP, Marshall LA, Alnemri ES, Williams WV, Doyle ML. Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. The Journal of Biological Chemistry. 275: 23319-25. PMID 10770955 DOI: 10.1074/jbc.M910438199  0.4
2000 Steplewski A, Ebel W, Planey SL, Alnemri ES, Robertson NM, Litwack G. Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II. Gene. 246: 169-78. PMID 10767538  1
1999 Mesner PW, Bible KC, Martins LM, Kottke TJ, Srinivasula SM, Svingen PA, Chilcote TJ, Basi GS, Tung JS, Krajewski S, Reed JC, Alnemri ES, Earnshaw WC, Kaufmann SH. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile. The Journal of Biological Chemistry. 274: 22635-45. PMID 10428844 DOI: 10.1074/jbc.274.32.22635  0.4
1999 Srinivasula SM, Ahmadt M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES. CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis Journal of Biological Chemistry. 274: 17946-17954. PMID 10364242 DOI: 10.1074/jbc.274.25.17946  0.4
1999 Saleh A, Srinivasula SM, Acharya S, Fishel R, Alnemri ES. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation Journal of Biological Chemistry. 274: 17941-17945. PMID 10364241 DOI: 10.1074/jbc.274.25.17941  0.4
1999 Samejima K, Svingen PA, Basi GS, Kottke T, Mesner PW, Stewart L, Durrieu F, Poirier GG, Alnemri ES, Champoux JJ, Kaufmann SH, Earnshaw WC. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. The Journal of Biological Chemistry. 274: 4335-40. PMID 9933635 DOI: 10.1074/jbc.274.7.4335  0.4
1999 Kang JJ, Schaber MD, Srinivasula SM, Alnemri ES, Litwack G, Hall DJ, Bjornsti MA. Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 274: 3189-98. PMID 9915859 DOI: 10.1074/jbc.274.5.3189  0.4
1998 Waterhouse NJ, Finucane DM, Green DR, Elce JS, Kumar S, Alnemri ES, Litwack G, Khanna K, Lavin MF, Watters DJ. Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death and Differentiation. 5: 1051-61. PMID 9894612 DOI: 10.1038/sj.cdd.4400425  1
1998 Zamai L, Ahmad M, Bennett IM, Azzoni L, Alnemri ES, Perussia B. Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells. The Journal of Experimental Medicine. 188: 2375-80. PMID 9858524 DOI: 10.1084/jem.188.12.2375  0.4
1998 Nguyen M, Branton PE, Roy S, Nicholson DW, Alnemri ES, Yeh WC, Mak TW, Shore GC. E1A-induced processing of procaspase-8 can occur independently of FADD and is inhibited by Bcl-2 Journal of Biological Chemistry. 273: 33099-33102. PMID 9837871 DOI: 10.1074/jbc.273.50.33099  0.4
1998 Walter BN, Huang Z, Jakobi R, Tuazon PT, Alnemri ES, Litwack G, Traugh JA. Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. The Journal of Biological Chemistry. 273: 28733-9. PMID 9786869 DOI: 10.1074/jbc.273.44.28733  0.4
1998 Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex Biochemistry. 37: 10757-10765. PMID 9692966 DOI: 10.1021/bi980893w  0.4
1998 Harvey KF, Harvey NL, Michael JM, Parasivam G, Waterhouse N, Alnemri ES, Watters D, Kumar S. Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis Journal of Biological Chemistry. 273: 13524-13530. PMID 9593687 DOI: 10.1074/jbc.273.22.13524  0.4
1998 Resnicoff M, Valentinis B, Herbert D, Abraham D, Friesen PD, Alnemri ES, Baserga R. The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts. The Journal of Biological Chemistry. 273: 10376-80. PMID 9553094 DOI: 10.1074/jbc.273.17.10376  0.4
1998 Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases Embo Journal. 17: 2215-2223. PMID 9545235 DOI: 10.1093/emboj/17.8.2215  0.4
1997 Song Q, Alnemri ES, Litwack G, Gilbert LI. An immunophilin is a component of the insect ecdysone receptor (EcR) complex. Insect Biochemistry and Molecular Biology. 27: 973-82. PMID 9501420  1
1997 Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Receptors & Signal Transduction. 7: 85-98. PMID 9392437  1
1997 Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91: 479-89. PMID 9390557 DOI: 10.1016/S0092-8674(00)80434-1  0.4
1997 Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. The Journal of Biological Chemistry. 272: 18542-5. PMID 9228018 DOI: 10.1074/jbc.272.30.18542  0.4
1997 D'Amours D, Duriez PJ, Orth K, Shah RG, Dixit VM, Earnshaw WC, Alnemri ES, Poirier GG. Purification of the death substrate poly(ADP-ribose) polymerase. Analytical Biochemistry. 249: 106-8. PMID 9193717 DOI: 10.1006/abio.1997.2153  0.4
1997 Sullivan W, Stensgard B, Caucutt G, Bartha B, McMahon N, Alnemri ES, Litwack G, Toft D. Nucleotides and two functional states of hsp90. The Journal of Biological Chemistry. 272: 8007-12. PMID 9065472  1
1997 Takahashi A, Goldschmidt-Clermont PJ, Alnemri ES, Fernandes-Alnemri T, Yoshizawa-Kumagaya K, Nakajima K, Sasada M, Poirier GG, Earnshaw WC. Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide. Experimental Cell Research. 231: 123-31. PMID 9056419 DOI: 10.1006/excr.1996.3459  0.4
1997 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Research. 57: 615-9. PMID 9044836  1
1997 Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ, Cohen JI. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 1172-6. PMID 9037025 DOI: 10.1073/pnas.94.4.1172  0.4
1997 Ahmad M, Srinivasula SM, Wang L, Litwack G, Fernandes-Alnemri T, Alnemri ES. Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35. The Journal of Biological Chemistry. 272: 1421-4. PMID 8999805  1
1997 Robertson NM, Zangrilli J, Fernandes-Alnemri T, Friesen PD, Litwack G, Alnemri ES. Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death Cancer Research. 57: 43-47. PMID 8988038  0.4
1997 Armstrong RC, Aja TJ, Hoang KD, Gaur S, Bai X, Alnemri ES, Litwack G, Karanewsky DS, Fritz LC, Tomaselli KJ. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 553-62. PMID 8987778  0.4
1996 Harvey NL, Trapani JA, Fernandes-Alnemri T, Litwack G, Alnemri ES, Kumar S. Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 1: 673-85. PMID 9078393  1
1996 Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proceedings of the National Academy of Sciences of the United States of America. 93: 14486-91. PMID 8962078  1
1996 Schumacher RJ, Hansen WJ, Freeman BC, Alnemri E, Litwack G, Toft DO. Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation Biochemistry. 35: 14889-14898. PMID 8942653 DOI: 10.1021/bi961825h  0.4
1996 Waterhouse N, Kumar S, Song Q, Strike P, Sparrow L, Dreyfuss G, Alnemri ES, Litwack G, Lavin M, Watters D. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis. The Journal of Biological Chemistry. 271: 29335-41. PMID 8910595  1
1996 Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. The Journal of Biological Chemistry. 271: 27099-106. PMID 8900201 DOI: 10.1074/jbc.271.43.27099  0.4
1996 Bullrich F, Fernandes-Alnemri T, Litwack G, Alnemri ES, Croce CM. Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3. Genomics. 36: 362-5. PMID 8812467 DOI: 10.1006/geno.1996.0476  1
1996 Song Q, Burrows SR, Smith G, Lees-Miller SP, Kumar S, Chan DW, Trapani JA, Alnemri E, Litwack G, Lu H, Moss DJ, Jackson S, Lavin MF. Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. The Journal of Experimental Medicine. 184: 619-26. PMID 8760815  0.4
1996 Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proceedings of the National Academy of Sciences of the United States of America. 93: 7464-9. PMID 8755496 DOI: 10.1073/pnas.93.15.7464  0.4
1996 Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 93: 8395-400. PMID 8710882 DOI: 10.1073/pnas.93.16.8395  1
1996 Song Q, Lees-Miller SP, Kumar S, Zhang N, Chan DW, Smith GCM, Jackson SP, Alnemri ES, Litwack G, Khanna KK, Lavin MF. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis Embo Journal. 15: 3238-3246. PMID 8670824  0.4
1995 Alnemri ES, Fernandes-Alnemri T, Litwack G. Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. The Journal of Biological Chemistry. 270: 4312-7. PMID 7876192  1
1995 Robertson NM, Bodine PV, Hsu TC, Alnemri ES, Litwack G. Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7. Cancer Research. 55: 548-56. PMID 7834624  1
1995 Fernandes-Alnemri T, Litwack G, Alnemri ES. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Research. 55: 2737-42. PMID 7796396  1
1995 Bodine PV, Alnemri ES, Litwack G. Synthetic peptides derived from the steroid binding domain block modulator and molybdate action toward the rat glucocorticoid receptor. Receptor. 5: 117-22. PMID 7580937  1
1994 Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. The Journal of Biological Chemistry. 269: 30761-4. PMID 7983002  1
1994 Alnemri ES, Fernandes-Alnemri T, Pomerenke K, Robertson NM, Dudley K, DuBois GC, Litwack G. FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. The Journal of Biological Chemistry. 269: 30828-34. PMID 7527037  0.4
1993 Alnemri ES, Litwack G. The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors. Biochemistry. 32: 5387-93. PMID 8388719  1
1993 Alnemri ES, Fernandes-Alnemri T, Nelki DS, Dudley K, DuBois GC, Litwack G. Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proceedings of the National Academy of Sciences of the United States of America. 90: 6839-43. PMID 8341706  0.4
1993 Robertson NM, Schulman G, Karnik S, Alnemri E, Litwack G. Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy. Molecular Endocrinology (Baltimore, Md.). 7: 1226-39. PMID 8247024 DOI: 10.1210/mend.7.9.8247024  1
1993 Heinrichs AA, Bortell R, Rahman S, Stein JL, Alnemri ES, Litwack G, Lian JB, Stein GS. Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter. Biochemistry. 32: 11436-44. PMID 8218210  1
1992 Alnemri ES, Fernandes TF, Litwack G, Haldar S, Croce CM. Involvement of BCL-2 in Glucocorticoid-induced Apoptosis of Human Pre-B-Leukemias Cancer Research. 52: 491-495. PMID 1728422  0.4
1992 Alnemri ES, Robertson NM, Fernandes TF, Croce CM, Litwack G. Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 7295-9. PMID 1502141  1
1992 Schulman G, Daniel V, Cooper M, Alnemri ES, Maksymowych AB, Litwack G. Characterization of in vitro translated human mineralocorticoid receptor. Structure and activation. Receptor. 2: 181-94. PMID 1335329  1
1991 Alnemri ES, Maksymowych AB, Robertson NM, Litwack G. Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system. The Journal of Biological Chemistry. 266: 3925-36. PMID 1995640  1
1991 Daniel V, Maksymowych AB, Alnemri ES, Litwack G. Cell-free synthesis of rat glucocorticoid receptor in rabbit reticulocyte lysate. In vitro synthesis of receptor in Mr 90,000 heat shock protein-depleted lysate. The Journal of Biological Chemistry. 266: 1320-5. PMID 1985950  1
1991 Alnemri ES, Maksymowych AB, Robertson NM, Litwack G. Overexpression and characterization of the human mineralocorticoid receptor. The Journal of Biological Chemistry. 266: 18072-81. PMID 1655735  1
1990 Alnemri ES, Litwack G. Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s). The Journal of Biological Chemistry. 265: 17323-33. PMID 2170373  1
1989 Alnemri ES, Litwack G. Glucocorticoid-induced lymphocytolysis is not mediated by an induced endonuclease. The Journal of Biological Chemistry. 264: 4104-11. PMID 2917990  1
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