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Graeme Conn - Publications

Affiliations: 
Biochemistry Emory University, Atlanta, GA 
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nandi S, Dey D, Srinivas P, Dunham CM, Conn GL. Distant Ribose 2'-O-Methylation of 23S rRNA Helix 69 Pre-Orders the Capreomycin Drug Binding Pocket at the Ribosome Subunit Interface. Biorxiv : the Preprint Server For Biology. PMID 39574593 DOI: 10.1101/2024.11.05.619916  0.599
2023 Strassler SE, Bowles IE, Krishnamohan A, Kim H, Edgington CB, Kuiper EG, Hancock CJ, Comstock LR, Jackman JE, Conn GL. tRNA mG9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10. The Journal of Biological Chemistry. 105443. PMID 37949221 DOI: 10.1016/j.jbc.2023.105443  0.378
2023 Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock LR, Dunham CM, Conn GL. 30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC. Proceedings of the National Academy of Sciences of the United States of America. 120: e2304128120. PMID 37307464 DOI: 10.1073/pnas.2304128120  0.664
2023 Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in FTD/ALS. Elife. 12. PMID 37073950 DOI: 10.7554/eLife.85902  0.327
2023 Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock LR, Dunham CM, Conn GL. 30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC. Biorxiv : the Preprint Server For Biology. PMID 36993224 DOI: 10.1101/2023.03.13.532395  0.648
2023 Strassler SE, Bowles IE, Krishnamohan A, Kim H, Kuiper EG, Comstock LR, Jackman JE, Conn GL. tRNA m G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10. Biorxiv : the Preprint Server For Biology. PMID 36778341 DOI: 10.1101/2023.02.01.526536  0.381
2022 Strassler SE, Bowles IE, Dey D, Jackman JE, Conn GL. Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases. The Journal of Biological Chemistry. 102393. PMID 35988649 DOI: 10.1016/j.jbc.2022.102393  0.475
2022 Laughlin ZT, Nandi S, Dey D, Zelinskaya N, Witek MA, Srinivas P, Nguyen HA, Kuiper EG, Comstock LR, Dunham CM, Conn GL. 50S subunit recognition and modification by the ribosomal RNA methyltransferase TlyA. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120352119. PMID 35357969 DOI: 10.1073/pnas.2120352119  0.641
2022 Schwartz SL, Dey D, Tanquary J, Bair CR, Lowen AC, Conn GL. Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35017296 DOI: 10.1073/pnas.2107111119  0.419
2021 Dey D, Ramakumar S, Conn GL. Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development. Journal of Chemical Information and Modeling. PMID 34516120 DOI: 10.1021/acs.jcim.1c00578  0.318
2020 Schwartz SL, Park EN, Vachon VK, Danzy S, Lowen AC, Conn GL. Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs. Nucleic Acids Research. 48: 7520-7531. PMID 32678884 DOI: 10.1093/nar/gkaa513  0.425
2019 Welty R, Rau M, Pabit S, Dunstan MS, Conn GL, Pollack L, Hall KB. Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain. Journal of Molecular Biology. PMID 31874150 DOI: 10.1016/j.jmb.2019.12.010  0.504
2019 Nosrati M, Dey D, Mehrani A, Strassler SE, Zelinskaya N, Hoffer ED, Stagg SM, Dunham CM, Conn GL. Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. The Journal of Biological Chemistry. PMID 31594862 DOI: 10.1074/Jbc.Ra119.011181  0.615
2019 Schwartz SL, Conn GL. RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase. Wiley Interdisciplinary Reviews. Rna. e1534. PMID 30989826 DOI: 10.1002/wrna.1534  0.425
2018 Calderon BM, Conn GL. A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1. The Journal of Biological Chemistry. PMID 30126839 DOI: 10.1074/jbc.RA118.004747  0.402
2017 Calderon BM, Conn GL. Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR. Rna (New York, N.Y.). 23: 557-566. PMID 28069888 DOI: 10.1261/rna.060269.116  0.48
2017 Witek MA, Kuiper EG, Minten E, Crispell EK, Conn GL. A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 292: 1977-1987. PMID 28031456 DOI: 10.1074/jbc.M116.752659  0.471
2016 Fasken MB, Losh JS, Leung SW, Brutus S, Avin B, Vaught JC, Potter-Birriel J, Craig T, Tsanova B, Conn GL, Mills-Lujan K, Corbett AH, van Hoof A. Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Genetics. PMID 27777260 DOI: 10.1534/Genetics.116.195917  0.405
2016 Vachon VK, Conn GL. Adenovirus VA RNA: An essential pro-viral non-coding RNA. Virus Research. 212: 39-52. PMID 26116898 DOI: 10.1016/j.virusres.2015.06.018  0.431
2016 Witek MA, Conn GL. Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization Nucleic Acids Research. 44: 342-353. DOI: 10.1093/nar/gkv1306  0.32
2015 S S, Schwartz SL, Conn GL. The Regulatory and Kinase Domains but not the Interdomain Linker Determine Human Double-Stranded RNA-Activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs. The Journal of Biological Chemistry. PMID 26432638 DOI: 10.1074/jbc.M115.679738  0.404
2015 Savic M, Sunita S, Zelinskaya N, Desai PM, Macmaster R, Vinal K, Conn GL. 30S Subunit-dependent activation of the Sorangium cellulosum So ce56 aminoglycoside resistance-conferring 16S rRNA methyltransferase Kmr. Antimicrobial Agents and Chemotherapy. 59: 2807-16. PMID 25733511 DOI: 10.1128/AAC.00056-15  0.319
2015 Vachon VK, Calderon BM, Conn GL. A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1. Nucleic Acids Research. 43: 544-52. PMID 25477390 DOI: 10.1093/nar/gku1289  0.396
2014 Kuiper EG, Conn GL. Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr). The Journal of Biological Chemistry. 289: 26189-200. PMID 25086036 DOI: 10.1074/jbc.M114.574780  0.522
2014 Wilson JL, Vachon VK, Sunita S, Schwartz SL, Conn GL. Dissection of the adenoviral VA RNAI central domain structure reveals minimum requirements for RNA-mediated inhibition of PKR. The Journal of Biological Chemistry. 289: 23233-45. PMID 24970889 DOI: 10.1074/jbc.M114.550046  0.455
2014 Witek MA, Conn GL. Expansion of the aminoglycoside-resistance 16S rRNA (m1A1408) methyltransferase family: Expression and functional characterization of four hypothetical enzymes of diverse bacterial origin Biochimica Et Biophysica Acta - Proteins and Proteomics. 1844: 1648-1655. PMID 24963996 DOI: 10.1016/j.bbapap.2014.06.012  0.308
2014 Dunkle JA, Vinal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL, Dunham CM. Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proceedings of the National Academy of Sciences of the United States of America. 111: 6275-80. PMID 24717845 DOI: 10.1073/Pnas.1402789111  0.583
2012 Vachon VK, Conn GL. Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments. Methods in Molecular Biology (Clifton, N.J.). 941: 157-69. PMID 23065560 DOI: 10.1007/978-1-62703-113-4_12  0.483
2012 Avis JM, Conn GL, Walker SC. Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5' and 3' ends. Methods in Molecular Biology (Clifton, N.J.). 941: 83-98. PMID 23065555 DOI: 10.1007/978-1-62703-113-4_7  0.358
2012 Linpinsel JL, Conn GL. General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE. Methods in Molecular Biology (Clifton, N.J.). 941: 43-58. PMID 23065552 DOI: 10.1007/978-1-62703-113-4_4  0.464
2011 Zelinskaya N, Rankin CR, Macmaster R, Savic M, Conn GL. Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies. Protein Expression and Purification. 75: 89-94. PMID 20667473 DOI: 10.1016/j.pep.2010.07.005  0.338
2011 Launer-Felty K, Wong CJ, Wahid AM, Conn GL, Cole JL. Inhibition of PKR by Adenovirus-Associated RNA I Biophysical Journal. 100: 232a-233a. DOI: 10.1016/j.bpj.2010.12.1484  0.365
2010 Launer-Felty K, Wong CJ, Wahid AM, Conn GL, Cole JL. Magnesium-dependent interaction of PKR with adenovirus VAI. Journal of Molecular Biology. 402: 638-44. PMID 20713064 DOI: 10.1016/j.jmb.2010.08.015  0.352
2010 Macmaster R, Zelinskaya N, Savic M, Rankin CR, Conn GL. Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. Nucleic Acids Research. 38: 7791-9. PMID 20639535 DOI: 10.1093/nar/gkq627  0.351
2010 Wong CJ, Heinicke LA, Launer-Felty K, Lary J, Conn GL, Bevilacqua PC, Cole JL. Regulation of PKR By Viral RNAS Biophysical Journal. 98: 13a. DOI: 10.1016/J.Bpj.2009.12.077  0.407
2009 Wahid AM, Coventry VK, Conn GL. The PKR-binding domain of adenovirus VA RNAI exists as a mixture of two functionally non-equivalent structures. Nucleic Acids Research. 37: 5830-7. PMID 19635730 DOI: 10.1093/nar/gkp595  0.48
2009 Savic M, Lovric J, Tomic TI, Vasiljevic B, Conn GL. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. Nucleic Acids Research. 37: 5420-31. PMID 19589804 DOI: 10.1093/nar/gkp575  0.328
2009 Dunstan MS, Hang PC, Zelinskaya NV, Honek JF, Conn GL. Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. The Journal of Biological Chemistry. 284: 17013-20. PMID 19369248 DOI: 10.1074/Jbc.M901618200  0.458
2008 Savic M, Ilic-Tomic T, Macmaster R, Vasiljevic B, Conn GL. Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. Journal of Bacteriology. 190: 5855-61. PMID 18586937 DOI: 10.1128/JB.00076-08  0.345
2008 Wahid AM, Coventry VK, Conn GL. Systematic deletion of the adenovirus-associated RNAI terminal stem reveals a surprisingly active RNA inhibitor of double-stranded RNA-activated protein kinase. The Journal of Biological Chemistry. 283: 17485-93. PMID 18430723 DOI: 10.1074/jbc.M802300200  0.466
2008 Coventry VK, Conn GL. Analysis of adenovirus VA RNAI structure and stability using compensatory base pair modifications. Nucleic Acids Research. 36: 1645-53. PMID 18250084 DOI: 10.1093/nar/gkn020  0.496
2008 Hobro AJ, Rouhi M, Conn GL, Blanch EW. Raman and Raman optical activity (ROA) analysis of RNA structural motifs Vibrational Spectroscopy. 48: 37-43. DOI: 10.1016/j.vibspec.2007.11.007  0.465
2007 Dunham CM, Conn GL. Recombinant RNA expression. Nature Methods. 4: 547-8. PMID 17599081 DOI: 10.1038/Nmeth0707-547  0.647
2007 Hobbs JR, Munger SD, Conn GL. Monellin (MNEI) at 1.15 A resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 162-7. PMID 17329805 DOI: 10.1107/S1744309107005271  0.351
2007 Hobro AJ, Rouhi M, Blanch EW, Conn GL. Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES Nucleic Acids Research. 35: 1169-1177. PMID 17264119 DOI: 10.1093/nar/gkm012  0.407
2006 Maeder C, Conn GL, Draper DE. Optimization of a ribosomal structural domain by natural selection. Biochemistry. 45: 6635-43. PMID 16716074 DOI: 10.1021/Bi052544P  0.684
2005 Dunstan MS, Guhathakurta D, Draper DE, Conn GL. Coevolution of protein and RNA structures within a highly conserved ribosomal domain. Chemistry & Biology. 12: 201-6. PMID 15734647 DOI: 10.1016/J.Chembiol.2004.11.019  0.726
2004 Phelan M, Banks RJ, Conn G, Ramesh V. NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element. Nucleic Acids Research. 32: 4715-24. PMID 15353559 DOI: 10.1093/Nar/Gkh805  0.512
2003 Clark AT, Robertson MEM, Conn GL, Belsham GJ. Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G Journal of Virology. 77: 12441-12449. PMID 14610168 DOI: 10.1128/JVI.77.23.12441-12449.2003  0.345
2003 Walker SC, Avis JM, Conn GL. General plasmids for producing RNA in vitro transcripts with homogeneous ends. Nucleic Acids Research. 31: e82. PMID 12888534  0.4
2003 Gyi JI, Gao D, Conn GL, Trent JO, Brown T, Lane AN. The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Research. 31: 2683-93. PMID 12736318 DOI: 10.1093/Nar/Gkg356  0.518
2002 Conn GL, Gittis AG, Lattman EE, Misra VK, Draper DE. A compact RNA tertiary structure contains a buried backbone-K+ complex. Journal of Molecular Biology. 318: 963-73. PMID 12054794 DOI: 10.1016/S0022-2836(02)00147-X  0.629
1999 Conn GL, Draper DE, Lattman EE, Gittis AG. Crystal structure of a conserved ribosomal protein-RNA complex. Science (New York, N.Y.). 284: 1171-4. PMID 10325228 DOI: 10.1126/Science.284.5417.1171  0.699
1999 Conn GL, Brown T, Leonard GA. The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution. Nucleic Acids Research. 27: 555-61. PMID 9862980 DOI: 10.1093/Nar/27.2.555  0.592
1998 Conn GL, Gutell RR, Draper DE. A functional ribosomal RNA tertiary structure involves a base triple interaction. Biochemistry. 37: 11980-8. PMID 9718323 DOI: 10.1021/Bi980825+  0.695
1998 Conn GL, Draper DE. RNA structure. Current Opinion in Structural Biology. 8: 278-85. PMID 9666322 DOI: 10.1016/S0959-440X(98)80059-6  0.676
1998 Gyi JI, Lane AN, Conn GL, Brown T. The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids. Nucleic Acids Research. 26: 3104-10. PMID 9628906 DOI: 10.1093/Nar/26.13.3104  0.582
1998 Gyi JI, Lane AN, Conn GL, Brown T. Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes. Biochemistry. 37: 73-80. PMID 9425027 DOI: 10.1021/Bi9719713  0.486
1997 Bonifacio GF, Brown T, Conn GL, Lane AN. Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes. Biophysical Journal. 73: 1532-8. PMID 9284320 DOI: 10.1016/S0006-3495(97)78185-2  0.555
1997 Conte MR, Conn GL, Brown T, Lane AN. Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2. Nucleic Acids Research. 25: 2627-34. PMID 9185574 DOI: 10.1093/Nar/25.13.2627  0.529
1997 Sutton DH, Conn GL, Brown T, Lane AN. The dependence of DNase I activity on the conformation of oligodeoxynucleotides. The Biochemical Journal. 481-6. PMID 9020884 DOI: 10.1042/Bj3210481  0.528
1996 Conte MR, Conn GL, Brown T, Lane AN. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR. Nucleic Acids Research. 24: 3693-9. PMID 8871546 DOI: 10.1093/Nar/24.19.3693  0.508
1996 Gyi JI, Conn GL, Lane AN, Brown T. Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes. Biochemistry. 35: 12538-48. PMID 8823191 DOI: 10.1021/Bi960948Z  0.558
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