Graeme Conn - Publications

Biochemistry Emory University, Atlanta, GA 

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dey D, Kavanaugh LG, Conn GL. Antibiotic substrate selectivity of MexY and MexB efflux systems is determined by a Goldilocks affinity. Antimicrobial Agents and Chemotherapy. PMID 32457110 DOI: 10.1128/AAC.00496-20  0.56
2019 Welty R, Rau M, Pabit S, Dunstan MS, Conn GL, Pollack L, Hall KB. Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain. Journal of Molecular Biology. PMID 31874150 DOI: 10.1016/j.jmb.2019.12.010  0.44
2019 Kuiper EG, Dey D, LaMore PA, Owings JP, Prezioso SM, Goldberg JB, Conn GL. Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM. The Journal of Biological Chemistry. PMID 31753919 DOI: 10.1074/jbc.RA119.011213  0.56
2019 Nosrati M, Dey D, Mehrani A, Strassler SE, Zelinskaya N, Hoffer ED, Stagg SM, Dunham CM, Conn GL. Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. The Journal of Biological Chemistry. PMID 31594862 DOI: 10.1074/jbc.RA119.011181  0.96
2017 Vinal K, Conn GL. Substrate recognition and modification by a pathogen-associated aminoglycoside-resistance 16S rRNA methyltransferase. Antimicrobial Agents and Chemotherapy. PMID 28289026 DOI: 10.1128/AAC.00077-17  0.32
2016 Owings JP, Kuiper EG, Prezioso SM, Meisner J, Varga JJ, Zelinskaya N, Dammer EB, Duong DM, Seyfried NT, Albertí S, Conn GL, Goldberg JB. Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase. The Journal of Biological Chemistry. 291: 3280-90. PMID 26677219 DOI: 10.1074/jbc.M115.706853  1
2016 Witek MA, Conn GL. Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization Nucleic Acids Research. 44: 342-353. DOI: 10.1093/nar/gkv1306  1
2015 Corrêa LL, Witek MA, Zelinskaya N, Picão RC, Conn GL. Heterologous expression and functional characterization of the exogenously acquired aminoglycoside-resistance methyltransferases RmtD, RmtD2 and RmtG. Antimicrobial Agents and Chemotherapy. PMID 26552988 DOI: 10.1128/AAC.02482-15  1
2015 Myers CL, Kuiper EG, Grant PC, Hernandez J, Conn GL, Honek JF. Functional roles in S-adenosyl-l-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase. Febs Letters. PMID 26450779 DOI: 10.1016/j.febslet.2015.09.028  1
2015 Zelinskaya N, Witek MA, Conn GL. The Pathogen-Derived Aminoglycoside Resistance 16S rRNA Methyltransferase NpmA Possesses Dual m1A1408/m1G1408 Specificity. Antimicrobial Agents and Chemotherapy. 59: 7862-5. PMID 26416864 DOI: 10.1128/AAC.01872-15  0.56
2015 Savic M, Sunita S, Zelinskaya N, Desai PM, Macmaster R, Vinal K, Conn GL. 30S Subunit-dependent activation of the Sorangium cellulosum So ce56 aminoglycoside resistance-conferring 16S rRNA methyltransferase Kmr. Antimicrobial Agents and Chemotherapy. 59: 2807-16. PMID 25733511 DOI: 10.1128/AAC.00056-15  1
2014 Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications. 5: 5395. PMID 25377354 DOI: 10.1038/ncomms6395  1
2014 Wilson JL, Vachon VK, Sunita S, Schwartz SL, Conn GL. Dissection of the adenoviral VA RNAI central domain structure reveals minimum requirements for RNA-mediated inhibition of PKR. The Journal of Biological Chemistry. 289: 23233-45. PMID 24970889 DOI: 10.1074/jbc.M114.550046  1
2014 Witek MA, Conn GL. Expansion of the aminoglycoside-resistance 16S rRNA (m1A1408) methyltransferase family: Expression and functional characterization of four hypothetical enzymes of diverse bacterial origin Biochimica Et Biophysica Acta - Proteins and Proteomics. 1844: 1648-1655. PMID 24963996 DOI: 10.1016/j.bbapap.2014.06.012  1
2014 Dunkle JA, Vinal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL, Dunham CM. Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proceedings of the National Academy of Sciences of the United States of America. 111: 6275-80. PMID 24717845 DOI: 10.1073/pnas.1402789111  1
2012 Avis JM, Conn GL, Walker SC. Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5' and 3' ends. Methods in Molecular Biology (Clifton, N.J.). 941: 83-98. PMID 23065555 DOI: 10.1007/978-1-62703-113-4_7  1
2011 Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin JH. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & Medicinal Chemistry Letters. 21: 4108-14. PMID 21632247 DOI: 10.1016/j.bmcl.2011.04.149  1
2011 Templeton CM, Ostovar pour S, Hobbs JR, Blanch EW, Munger SD, Conn GL. Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix. Chemical Senses. 36: 425-34. PMID 21343241 DOI: 10.1093/chemse/bjr007  1
2011 Zelinskaya N, Rankin CR, Macmaster R, Savic M, Conn GL. Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies. Protein Expression and Purification. 75: 89-94. PMID 20667473 DOI: 10.1016/j.pep.2010.07.005  0.56
2010 Launer-Felty K, Wong CJ, Wahid AM, Conn GL, Cole JL. Magnesium-dependent interaction of PKR with adenovirus VAI. Journal of Molecular Biology. 402: 638-44. PMID 20713064 DOI: 10.1016/j.jmb.2010.08.015  1
2010 Macmaster R, Zelinskaya N, Savic M, Rankin CR, Conn GL. Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. Nucleic Acids Research. 38: 7791-9. PMID 20639535 DOI: 10.1093/nar/gkq627  0.56
2009 Moric I, Bajkic S, Savic M, Tomic TI, Conn GL, Vasiljevic B. Heterologous Escherichia coli expression, purification and characterization of the GrmA aminoglycoside-resistance methyltransferase. The Protein Journal. 28: 326-32. PMID 19763405 DOI: 10.1007/s10930-009-9197-9  0.32
2009 Savic M, Lovric J, Tomic TI, Vasiljevic B, Conn GL. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. Nucleic Acids Research. 37: 5420-31. PMID 19589804 DOI: 10.1093/nar/gkp575  0.32
2009 Dunstan MS, Hang PC, Zelinskaya NV, Honek JF, Conn GL. Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. The Journal of Biological Chemistry. 284: 17013-20. PMID 19369248 DOI: 10.1074/jbc.M901618200  1
2008 Savic M, Ilic-Tomic T, Macmaster R, Vasiljevic B, Conn GL. Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. Journal of Bacteriology. 190: 5855-61. PMID 18586937 DOI: 10.1128/JB.00076-08  0.32
2008 Vigues S, Hobbs JR, Nie Y, Conn GL, Munger SD. T1R2, T1R3, and the detection of sweet stimuli Acs Symposium Series. 979: 65-75. DOI: 10.1021/bk-2008-0979.ch004  1
2008 Hobro AJ, Rouhi M, Conn GL, Blanch EW. Raman and Raman optical activity (ROA) analysis of RNA structural motifs Vibrational Spectroscopy. 48: 37-43. DOI: 10.1016/j.vibspec.2007.11.007  1
2007 Dunham CM, Conn GL. Recombinant RNA expression. Nature Methods. 4: 547-8. PMID 17599081 DOI: 10.1038/nmeth0707-547  1
2007 Hobbs JR, Munger SD, Conn GL. Monellin (MNEI) at 1.15 A resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 162-7. PMID 17329805 DOI: 10.1107/S1744309107005271  1
2007 Hobro AJ, Rouhi M, Blanch EW, Conn GL. Raman and Raman optical activity (ROA) analysis of RNA structural motifs in Domain I of the EMCV IRES Nucleic Acids Research. 35: 1169-1177. PMID 17264119 DOI: 10.1093/nar/gkm012  1
2006 Maeder C, Conn GL, Draper DE. Optimization of a ribosomal structural domain by natural selection. Biochemistry. 45: 6635-43. PMID 16716074 DOI: 10.1021/bi052544p  1
2006 Nie Y, Hobbs JR, Vigues S, Olson WJ, Conn GL, Munger SD. Expression and purification of functional ligand-binding domains of T1R3 taste receptors. Chemical Senses. 31: 505-13. PMID 16621970 DOI: 10.1093/chemse/bjj053  1
2005 Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Current Biology : Cb. 15: 1948-52. PMID 16271873 DOI: 10.1016/j.cub.2005.09.037  1
2005 Dunstan MS, Guhathakurta D, Draper DE, Conn GL. Coevolution of protein and RNA structures within a highly conserved ribosomal domain. Chemistry & Biology. 12: 201-6. PMID 15734647 DOI: 10.1016/j.chembiol.2004.11.019  1
2003 Clark AT, Robertson MEM, Conn GL, Belsham GJ. Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G Journal of Virology. 77: 12441-12449. PMID 14610168 DOI: 10.1128/JVI.77.23.12441-12449.2003  1
2003 Walker SC, Avis JM, Conn GL. General plasmids for producing RNA in vitro transcripts with homogeneous ends. Nucleic Acids Research. 31: e82. PMID 12888534  1
2003 Gyi JI, Gao D, Conn GL, Trent JO, Brown T, Lane AN. The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Research. 31: 2683-93. PMID 12736318  0.64
2002 Conn GL, Gittis AG, Lattman EE, Misra VK, Draper DE. A compact RNA tertiary structure contains a buried backbone-K+ complex. Journal of Molecular Biology. 318: 963-73. PMID 12054794 DOI: 10.1016/S0022-2836(02)00147-X  1
1999 Conn GL, Draper DE, Lattman EE, Gittis AG. Crystal structure of a conserved ribosomal protein-RNA complex. Science (New York, N.Y.). 284: 1171-4. PMID 10325228 DOI: 10.1126/science.284.5417.1171  1
1999 Conn GL, Brown T, Leonard GA. The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution. Nucleic Acids Research. 27: 555-61. PMID 9862980 DOI: 10.1093/NAR/27.2.555  0.64
1998 Conn GL, Gutell RR, Draper DE. A functional ribosomal RNA tertiary structure involves a base triple interaction. Biochemistry. 37: 11980-8. PMID 9718323 DOI: 10.1021/bi980825+  1
1998 Conn GL, Draper DE. RNA structure. Current Opinion in Structural Biology. 8: 278-85. PMID 9666322 DOI: 10.1016/S0959-440X(98)80059-6  1
1998 Gyi JI, Lane AN, Conn GL, Brown T. The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids. Nucleic Acids Research. 26: 3104-10. PMID 9628906 DOI: 10.1093/nar/26.13.3104  0.56
1998 Gyi JI, Lane AN, Conn GL, Brown T. Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes. Biochemistry. 37: 73-80. PMID 9425027 DOI: 10.1021/BI9719713  0.64
1997 Bonifacio GF, Brown T, Conn GL, Lane AN. Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes. Biophysical Journal. 73: 1532-8. PMID 9284320 DOI: 10.1016/S0006-3495(97)78185-2  0.64
1997 Conte MR, Conn GL, Brown T, Lane AN. Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2. Nucleic Acids Research. 25: 2627-34. PMID 9185574 DOI: 10.1093/nar/25.13.2627  0.44
1997 Sutton DH, Conn GL, Brown T, Lane AN. The dependence of DNase I activity on the conformation of oligodeoxynucleotides. The Biochemical Journal. 481-6. PMID 9020884 DOI: 10.1042/bj3210481  0.4
1996 Conte MR, Conn GL, Brown T, Lane AN. Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR. Nucleic Acids Research. 24: 3693-9. PMID 8871546 DOI: 10.1093/nar/24.19.3693  0.4
1996 Gyi JI, Conn GL, Lane AN, Brown T. Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes. Biochemistry. 35: 12538-48. PMID 8823191 DOI: 10.1021/bi960948z  0.6
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