Michael Derek Waterfield - Publications

1972-1986 Biochemistry Imperial Cancer Research Fund 

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Nagano K, Akpan A, Warnasuriya G, Corless S, Totty N, Yang A, Stein R, Zvelebil M, Stensballe A, Burlingame A, Waterfield M, Cramer R, Timms JF, Naaby-Hansen S. Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts. Molecular & Cellular Proteomics : McP. 11: 1690-708. PMID 22956732 DOI: 10.1074/Mcp.M112.019778  0.468
2010 Chan HL, Chou HC, Duran M, Gruenewald J, Waterfield MD, Ridley A, Timms JF. Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells. The Journal of Biological Chemistry. 285: 4307-18. PMID 19996095 DOI: 10.1074/Jbc.M109.047027  0.433
2010 Chan H, Chou H, Duran M, Gruenewald J, Waterfield MD, Ridley A, Timms JF. Phosphoproteomic analysis of oxidative stress in mammary epithelial cells: Major role of Src kinase-dependent phosphorylation in regulating adhesion F1000research. 1. DOI: 10.7490/F1000Research.555.1  0.378
2009 Panasyuk G, Nemazanyy I, Zhyvoloup A, Filonenko V, Davies D, Robson M, Pedley RB, Waterfield M, Gout I. mTORβ Splicing Isoform Promotes Cell Proliferation and Tumorigenesis Journal of Biological Chemistry. 284: 30807-30814. PMID 19726679 DOI: 10.1074/Jbc.M109.056085  0.394
2008 Zvelebil MJ, Waterfield MD, Shuttleworth SJ. Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors. Archives of Biochemistry and Biophysics. 477: 404-10. PMID 18647592 DOI: 10.1016/J.Abb.2008.06.024  0.385
2008 Jefferies HB, Cooke FT, Jat P, Boucheron C, Koizumi T, Hayakawa M, Kaizawa H, Ohishi T, Workman P, Waterfield MD, Parker PJ. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. Embo Reports. 9: 164-70. PMID 18188180 DOI: 10.1038/Sj.Embor.7401155  0.345
2008 O'Brien R, Rugman P, Renzoni D, Layton M, Handa R, Hilyard K, Waterfield MD, Driscoll PC, Ladbury JE. Alternative modes of binding of proteins with tandem SH2 domains Protein Science. 9: 570-579. PMID 10752619 DOI: 10.1110/Ps.9.3.570  0.428
2007 Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Parker P, Workman P, Waterfield MD. Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorganic & Medicinal Chemistry. 15: 5837-44. PMID 17601739 DOI: 10.1016/J.Bmc.2007.05.070  0.301
2007 Jovceva E, Larsen MR, Waterfield MD, Baum B, Timms JF. Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. Journal of Cell Science. 120: 1888-97. PMID 17504806 DOI: 10.1242/Jcs.004366  0.337
2007 Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman JO, Akpan A, Yang A, Zvelebil M, Cramer R, Stimson L, Aherne W, Banerji U, Judson I, Sharp S, Powers M, ... ... Waterfield M, et al. Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Research. 67: 3239-53. PMID 17409432 DOI: 10.1158/0008-5472.Can-06-2968  0.323
2007 Gharbi SI, Zvelebil MJ, Shuttleworth SJ, Hancox T, Saghir N, Timms JF, Waterfield MD. Exploring the specificity of the PI3K family inhibitor LY294002. The Biochemical Journal. 404: 15-21. PMID 17302559 DOI: 10.1042/Bj20061489  0.429
2006 Stahelin RV, Karathanassis D, Bruzik KS, Waterfield MD, Bravo J, Williams RL, Cho W. Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. The Journal of Biological Chemistry. 281: 39396-406. PMID 17038310 DOI: 10.1074/Jbc.M607079200  0.359
2006 Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A. Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Molecular Biology of the Cell. 17: 3729-44. PMID 16775008 DOI: 10.1091/Mbc.E05-11-1083  0.601
2006 Weeks ME, Sinclair J, Butt A, Chung YL, Worthington JL, Wilkinson CR, Griffiths J, Jones N, Waterfield MD, Timms JF. A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe. Proteomics. 6: 2772-96. PMID 16548067 DOI: 10.1002/Pmic.200500741  0.342
2005 Chan HL, Gharbi S, Gaffney PR, Cramer R, Waterfield MD, Timms JF. Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis. Proteomics. 5: 2908-26. PMID 15954156 DOI: 10.1002/Pmic.200401300  0.308
2005 Cutillas PR, Geering B, Waterfield MD, Vanhaesebroeck B. Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line. Molecular & Cellular Proteomics : McP. 4: 1038-51. PMID 15879432 DOI: 10.1074/mcp.M500078-MCP200  0.302
2005 Cutillas PR, Biber J, Marks J, Jacob R, Stieger B, Cramer R, Waterfield M, Burlingame AL, Unwin RJ. Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex. Proteomics. 5: 101-12. PMID 15593129 DOI: 10.1002/Pmic.200400886  0.33
2004 MacDougall LK, Gagou ME, Leevers SJ, Hafen E, Waterfield MD. Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways. Molecular and Cellular Biology. 24: 796-808. PMID 14701751 DOI: 10.1128/Mcb.24.2.796-808.2004  0.434
2002 Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ. Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. The Embo Journal. 21: 5097-108. PMID 12356726 DOI: 10.1093/Emboj/Cdf512  0.458
2002 Timms JF, White SL, O'Hare MJ, Waterfield MD. Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells. Oncogene. 21: 6573-86. PMID 12242655 DOI: 10.1038/Sj.Onc.1205847  0.338
2002 Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E, Pearce W, Meek SE, Salpekar A, Waterfield MD, Smith AJ, Vanhaesebroeck B. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science (New York, N.Y.). 297: 1031-4. PMID 12130661 DOI: 10.1126/Science.1073560  0.429
2002 Gharbi S, Gaffney P, Yang A, Zvelebil MJ, Cramer R, Waterfield MD, Timms JF. Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system. Molecular & Cellular Proteomics : McP. 1: 91-8. PMID 12096126 DOI: 10.1074/Mcp.T100007-Mcp200  0.32
2002 Benvenuti S, Cramer R, Quinn CC, Bruce J, Zvelebil M, Corless S, Bond J, Yang A, Hockfield S, Burlingame AL, Waterfield MD, Jat PS. Differential proteome analysis of replicative senescence in rat embryo fibroblasts. Molecular & Cellular Proteomics : McP. 1: 280-92. PMID 12096110 DOI: 10.1074/Mcp.M100028-Mcp200  0.333
2002 Benvenuti S, Cramer R, Bruce J, Waterfield MD, Jat PS. Identification of novel candidates for replicative senescence by functional proteomics. Oncogene. 21: 4403-13. PMID 12080471 DOI: 10.1038/Sj.Onc.1205525  0.321
2001 Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer Annual Review of Cell and Developmental Biology. 17: 615-675. PMID 11687500 DOI: 10.1146/Annurev.Cellbio.17.1.615  0.4
2001 Pirola L, Zvelebil MJ, Bulgarelli-Leva G, Obberghen EV, Waterfield MD, Wymann MP. Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα) FUNCTIONS OF LIPID KINASE-DEFICIENT PI3Kα IN SIGNALING Journal of Biological Chemistry. 276: 21544-21554. PMID 11278889 DOI: 10.1074/Jbc.M011330200  0.475
2000 Stein RC, Waterfield MD. PI3-kinase inhibition: a target for drug development? Molecular Medicine Today. 6: 347-358. PMID 10954868 DOI: 10.1016/S1357-4310(00)01770-6  0.406
2000 Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein The Embo Journal. 19: 4015-4025. PMID 10921882 DOI: 10.1093/Emboj/19.15.4015  0.433
2000 Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J. Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors Molecular and Cellular Biology. 20: 3817-3830. PMID 10805725 DOI: 10.1128/Mcb.20.11.3817-3830.2000  0.468
2000 Domin J, Gaidarov I, Smith MEK, Keen JH, Waterfield MD. The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles Journal of Biological Chemistry. 275: 11943-11950. PMID 10766823 DOI: 10.1074/Jbc.275.16.11943  0.406
2000 PAREKH DB, KATSO RM, LESLIE NR, DOWNES CP, PROCYK KJ, WATERFIELD MD, PARKER PJ. β1-Integrin and PTEN control the phosphorylation of protein kinase C Biochemical Journal. 352: 425-433. DOI: 10.1042/BJ3520425  0.338
1999 Vanhaesebroeck B, Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Experimental Cell Research. 253: 239-54. PMID 10579926 DOI: 10.1006/EXCR.1999.4701  0.304
1999 Page MJ, Amess B, Townsend RR, Parekh R, Herath A, Brusten L, Zvelebil MJ, Stein RC, Waterfield MD, Davies SC, O'Hare MJ. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Proceedings of the National Academy of Sciences of the United States of America. 96: 12589-94. PMID 10535966 DOI: 10.1073/Pnas.96.22.12589  0.314
1999 Weinkove D, Neufeld TP, Twardzik T, Waterfield MD, Leevers SJ. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Current Biology : Cb. 9: 1019-29. PMID 10508611 DOI: 10.1016/S0960-9822(99)80450-3  0.384
1999 Beeton CA, Das P, Waterfield MD, Shepherd PR. The SH3 and BH Domains of the p85α Adapter Subunit Play a Critical Role in Regulating Class Ia Phosphoinositide 3-Kinase Function Molecular Cell Biology Research Communications. 1: 153-157. PMID 10356365 DOI: 10.1006/Mcbr.1999.0124  0.437
1999 Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR. Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. Journal of Biological Chemistry. 274: 14529-14532. PMID 10329640 DOI: 10.1074/Jbc.274.21.14529  0.345
1999 Harpur AG, Layton MJ, Das P, Bottomley MJ, Panayotou G, Driscoll PC, Waterfield MD. Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 274: 12323-32. PMID 10212202 DOI: 10.1074/Jbc.274.18.12323  0.363
1999 Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Current Opinion in Cell Biology. 11: 219-225. PMID 10209156 DOI: 10.1016/S0955-0674(99)80029-5  0.407
1999 Vanhaesebroeck B, Higashi K, Raven C, Welham M, Anderson S, Brennan P, Ward SG, Waterfield MD. Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. The Embo Journal. 18: 1292-302. PMID 10064595 DOI: 10.1093/Emboj/18.5.1292  0.461
1999 Surdo PL, Bottomley MJ, Arcaro A, Siegal G, Panayotou G, Sankar A, Gaffney PR, Riley AM, Potter BV, Waterfield MD, Driscoll PC. Structural and Biochemical Evaluation of the Interaction of the Phosphatidylinositol 3-Kinase p85α Src Homology 2 Domains with Phosphoinositides and Inositol Polyphosphates Journal of Biological Chemistry. 274: 15678-15685. DOI: 10.1074/Jbc.274.22.15678  0.435
1998 Layton MJ, Harpur AG, Panayotou G, Bastiaens PIH, Waterfield MD. Binding of a Diphosphotyrosine-containing Peptide That Mimics Activated Platelet-derived Growth Factor Receptor β Induces Oligomerization of Phosphatidylinositol 3-Kinase Journal of Biological Chemistry. 273: 33379-33385. PMID 9837914 DOI: 10.1074/Jbc.273.50.33379  0.428
1998 Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD. Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity Journal of Biological Chemistry. 273: 33082-33090. PMID 9830063 DOI: 10.1074/Jbc.273.49.33082  0.599
1998 Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. Journal of Biological Chemistry. 273: 30061-30064. PMID 9804755 DOI: 10.1074/Jbc.273.46.30061  0.436
1998 Turner SJ, Domin J, Waterfield MD, Ward SG, Westwick J. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. The Journal of Biological Chemistry. 273: 25987-95. PMID 9748276 DOI: 10.1074/Jbc.273.40.25987  0.438
1998 Siegal G, Davis B, Kristensen SM, Sankar A, Linacre J, Stein RC, Panayotou G, Waterfield MD, Driscoll PC. Solution structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase Journal of Molecular Biology. 276: 461-478. PMID 9512716 DOI: 10.1006/Jmbi.1997.1562  0.369
1997 Uellner R, Zvelebil MJ, Hopkins J, Jones J, MacDougall LK, Morgan BP, Podack E, Waterfield MD, Griffiths GM. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. The Embo Journal. 16: 7287-96. PMID 9405358 DOI: 10.1093/Emboj/16.24.7287  0.36
1997 Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochemical Journal. 326: 139-147. PMID 9337861 DOI: 10.1042/Bj3260139  0.359
1997 Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends in Biochemical Sciences. 22: 267-272. PMID 9255069 DOI: 10.1016/S0968-0004(97)01061-X  0.396
1997 Weinkove D, Leevers SJ, MacDougall LK, Waterfield MD. p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110 Journal of Biological Chemistry. 272: 14606-14610. PMID 9169420 DOI: 10.1074/Jbc.272.23.14606  0.42
1997 Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell. 89: 457-67. PMID 9150145 DOI: 10.1016/S0092-8674(00)80226-3  0.558
1997 Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 94: 4330-5. PMID 9113989 DOI: 10.1073/Pnas.94.9.4330  0.638
1997 Linassier C, MacDOUGALL LK, Domin J, Waterfield MD. Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase Biochemical Journal. 321: 849-856. PMID 9032475 DOI: 10.1042/Bj3210849  0.425
1997 Panaretou C, Domin J, Cockcroft S, Waterfield MD. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex. Journal of Biological Chemistry. 272: 2477-2485. PMID 8999962 DOI: 10.1074/Jbc.272.4.2477  0.472
1996 Renzoni DA, Pugh DJR, Siligardi G, Das P, Morton CJ, Rossi C, Waterfield MD, Campbell ID, Ladbury JE. Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase Biochemistry. 35: 15646-15653. PMID 8961927 DOI: 10.1021/Bi9620969  0.345
1996 MacDougall LK, Waterfield MD. Receptor signalling: To sevenless, a daughter Current Biology. 6: 1250-1253. PMID 8939558 DOI: 10.1016/S0960-9822(02)70709-4  0.306
1996 Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I. Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases Current Biology. 6: 981-988. PMID 8805332 DOI: 10.1016/S0960-9822(02)00642-5  0.47
1996 Finan P, Koga H, Zvelebil MJ, Waterfield MD, Kellie S. The C-terminal SH3 Domain of p67phoxBinds its Natural Ligand in a Reverse Orientation Journal of Molecular Biology. 261: 173-180. PMID 8757285 DOI: 10.1006/Jmbi.1996.0450  0.344
1996 Domin J, Dhand R, Waterfield MD. Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo. Journal of Biological Chemistry. 271: 21614-21621. PMID 8702949 DOI: 10.1074/Jbc.271.35.21614  0.455
1996 Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. The Embo Journal. 15: 2442-51. PMID 8665852 DOI: 10.1002/J.1460-2075.1996.Tb00602.X  0.532
1996 Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, Panayotou G. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Molecular and Cellular Biology. 16: 1722-33. PMID 8657148 DOI: 10.1128/MCB.16.4.1722  0.34
1996 Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M. Interaction of Shc with Adaptor Protein Adaptins Journal of Biological Chemistry. 271: 5265-5269. PMID 8617812 DOI: 10.1074/Jbc.271.9.5265  0.367
1996 Kitamura T, Kitamura Y, Kazuyoshi, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Biochemical and Biophysical Research Communications. 219: 509-514. PMID 8605018 DOI: 10.1006/Bbrc.1996.0264  0.4
1996 Leevers SJ, Weinkove D, MacDougall LK, Hafen E, Waterfield MD. The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. The Embo Journal. 15: 6584-6594. DOI: 10.1002/J.1460-2075.1996.Tb01049.X  0.349
1995 MacDougall LK, Domin J, Waterfield MD. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Current Biology. 5: 1404-1415. PMID 8749393 DOI: 10.1016/S0960-9822(95)00278-8  0.478
1995 Woscholski R, Waterfield MD, Parker PJ. Purification and biochemical characterization of a mammalian phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Journal of Biological Chemistry. 270: 31001-31007. PMID 8537357 DOI: 10.1074/Jbc.270.52.31001  0.363
1995 Zvelebil MJJM, Panayotou G, Linacre J, Waterfield MD. Prediction and analysis of SH2 domain-phosphopeptide interactions. Protein Engineering. 8: 527-534. PMID 8532676 DOI: 10.1093/Protein/8.6.527  0.409
1995 Hara K, Yonezawa K, Sakaue H, Kotani K, Kojima A, Waterfield MD, Kasuga M. Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase Biochemical and Biophysical Research Communications. 208: 735-741. PMID 7695630 DOI: 10.1006/Bbrc.1995.1399  0.418
1995 Woscholski R, Kodaki T, Palmer RH, Waterfield MD, Parker PJ. Modulation of the Substrate Specificity of the Mammalian Phosphatidylinositol 3-Kinase by Cholesterol Sulfate and Sulfatide Biochemistry. 34: 11489-11493. PMID 7547877 DOI: 10.1021/Bi00036A022  0.43
1995 Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. The Embo Journal. 14: 3339-3348. DOI: 10.1002/J.1460-2075.1995.Tb07340.X  0.492
1994 Woscholski R, Kodaki T, McKinnon M, Waterfield MD, Parker PJ. A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase Febs Letters. 342: 109-114. PMID 8143860 DOI: 10.1016/0014-5793(94)80482-6  0.42
1994 Kodaki T, Woscholski R, Emr S, Waterfield MD, Nurse P, Parker PJ. Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product. European Journal of Biochemistry. 219: 775-80. PMID 8112328 DOI: 10.1111/J.1432-1033.1994.Tb18557.X  0.433
1994 Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature. 370: 527-32. PMID 8052307 DOI: 10.1038/370527A0  0.532
1994 Stephens L, Cooke FT, Walters R, Jackson T, Volinia S, Gout I, Waterfield MD, Hawkins PT. Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Current Biology : Cb. 4: 203-14. PMID 7922325 DOI: 10.1016/S0960-9822(00)00049-X  0.36
1994 Downing AK, Driscoll PC, Gout I, Salim K, Zvelebil MJ, Waterfield MD. Three-dimensional solution structure of the pleckstrin homology domain from dynamin Current Biology. 4: 884-891. PMID 7850421 DOI: 10.1016/S0960-9822(00)00197-4  0.318
1994 Roche S, Dhand R, Waterfield MD, Courtneidge SA. The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen pp60(c-src) complexes Biochemical Journal. 301: 703-711. PMID 7519847 DOI: 10.1042/Bj3010703  0.33
1994 Kauffmann-Zeh A, Klinger R, Endemann G, Waterfield MD, Wetzker R, Hsuan JJ. Regulation of human type II phosphatidylinositol kinase activity by epidermal growth factor-dependent phosphorylation and receptor association. Journal of Biological Chemistry. 269: 31243-31251. DOI: 10.1016/s0021-9258(18)47415-7  0.313
1993 Panayotou G, Gish G, End P, Truong O, Gout I, Dhand R, Fry MJ, Hiles I, Pawson T, Waterfield MD. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Molecular and Cellular Biology. 13: 3567-76. PMID 8388538 DOI: 10.1128/mcb.13.6.3567-3576.1993  0.342
1993 Panayotou G, Waterfield MD. The assembly of signalling complexes by receptor tyrosine kinases. Bioessays. 15: 171-177. PMID 8387783 DOI: 10.1002/Bies.950150305  0.455
1993 Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (New York, N.Y.). 260: 88-91. PMID 8385367 DOI: 10.1126/Science.8385367  0.471
1993 Fry MJ, Panayotou G, Booker GW, Waterfield MD. New insights into protein-tyrosine kinase receptor signaling complexes. Protein Science : a Publication of the Protein Society. 2: 1785-97. PMID 8268793 DOI: 10.1002/Pro.5560021102  0.441
1993 Fry MJ, Waterfield MD. Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 340: 337-44. PMID 8103937 DOI: 10.1098/Rstb.1993.0076  0.474
1993 Ponzetto C, Bardelli A, Maina F, Longati P, Panayotou G, Dhand R, Waterfield MD, Comoglio PM. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Molecular and Cellular Biology. 13: 4600-8. PMID 7687741 DOI: 10.1128/mcb.13.8.4600-4608.1993  0.357
1993 Booker GW, Gout I, Downing AK, Driscoll PC, Boyd J, Waterfield MD, Campbell ID. Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Cell. 73: 813-22. PMID 7684655 DOI: 10.1016/0092-8674(93)90259-S  0.403
1993 Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF. Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor Embo Journal. 12: 943-950. PMID 7681396 DOI: 10.1002/J.1460-2075.1993.Tb05735.X  0.308
1993 Ponzetto C, Bardelli A, Maina F, Longati P, Panayotou G, Dhand R, Waterfield MD, Comoglio PM. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Molecular and Cellular Biology. 13: 4600-4608. DOI: 10.1128/MCB.13.8.4600  0.357
1993 Panayotou G, Gish G, End P, Truong O, Gout I, Dhand R, Fry MJ, Hiles I, Pawson T, Waterfield MD. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Molecular and Cellular Biology. 13: 3567-3576. DOI: 10.1128/MCB.13.6.3567  0.342
1993 Gout I, Dhand R, Hiles ID, Fry MJ, Panayotou G, Das P, Truong O, Totty NF, Hsuan J, Booker GW, Campbell ID, Waterfield MD. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell. 75: 25-36. DOI: 10.1016/S0092-8674(05)80081-9  0.392
1992 Panayotou G, Waterfield MD. Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes Trends in Cell Biology. 2: 358-360. PMID 14731956 DOI: 10.1016/0962-8924(92)90042-L  0.498
1992 End P, Panayotou G, Entwistle A, Waterfield MD, Chiquet M. Tenascin: a modulator of cell growth Febs Journal. 209: 1041-1051. PMID 1385122 DOI: 10.1111/J.1432-1033.1992.Tb17380.X  0.386
1992 Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD. Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. The Biochemical Journal. 288: 395-405. PMID 1334406 DOI: 10.1042/BJ2880395  0.349
1992 Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I, Waterfield MD, Campbell ID. Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Nature. 358: 684-7. PMID 1323062 DOI: 10.1038/358684A0  0.394
1992 Fry MJ, Panayotou G, Dhand R, Ruiz-Larrea F, Gout I, Nguyen O, Courtneidge SA, Waterfield MD. Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns. The Biochemical Journal. 288: 383-93. PMID 1281404 DOI: 10.1042/Bj2880383  0.391
1992 Ward S, Reif K, Ley S, Fry M, Waterfield M, Cantrell D. Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases. Journal of Biological Chemistry. 267: 23862-23869. DOI: 10.1016/s0021-9258(18)35916-7  0.314
1992 Panayotou G, Bax B, Gout I, Federwisch M, Wroblowski B, Dhand R, Fry M, Blundell T, Wollmer A, Waterfield M. Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. The Embo Journal. 11: 4261-4272. DOI: 10.1002/j.1460-2075.1992.tb05524.x  0.31
1992 Reedijk M, Liu X, van der Geer P, Letwin K, Waterfield M, Hunter T, Pawson T. Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. The Embo Journal. 11: 1365-1372. DOI: 10.1002/J.1460-2075.1992.Tb05181.X  0.356
1991 Waterfield MD, Greenfield C. Expression and properties of epidermal growth factor receptor expressed from baculovirus vectors. Methods in Enzymology. 200: 627-645. PMID 1956340 DOI: 10.1016/0076-6879(91)00176-W  0.374
1991 Wetzker R, Klinger R, Hsuan J, Fry MJ, Kauffmann-Zeh A, Müller E, Frunder H, Waterfield M. Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes. European Journal of Biochemistry / Febs. 200: 179-85. PMID 1652438 DOI: 10.1111/J.1432-1033.1991.Tb21065.X  0.379
1989 Hsuan JJ, Downward J, Clark S, Waterfield MD. Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor. The Biochemical Journal. 259: 519-27. PMID 2719663 DOI: 10.1042/Bj2590519  0.526
1989 Panayotou G, Waterfield MD. Cell surface receptors for polypeptide hormones, growth factors and neuropeptides. Current Opinion in Cell Biology. 1: 167-176. PMID 2698668 DOI: 10.1016/0955-0674(89)90082-3  0.306
1989 Hsuan JJ, Panayotou G, Waterfield MD. Structural basis for epidermal growth factor receptor function. Progress in Growth Factor Research. 1: 23-32. PMID 2491253 DOI: 10.1016/0955-2235(89)90039-2  0.361
1989 Greenfield C, Hiles I, Waterfield M, Federwisch M, Wollmer A, Blundell T, McDonald N. Epidermal growth factor binding induces a conformational change in the external domain of its receptor. The Embo Journal. 8: 4115-4123. DOI: 10.1002/J.1460-2075.1989.Tb08596.X  0.352
1988 Clark S, Cheng DJ, Hsuan JJ, Haley JD, Waterfield MD. Loss of three major auto phosphorylation sites in the EGF receptor does not block the mitogenic action of EGF. Journal of Cellular Physiology. 134: 421-428. PMID 3258313 DOI: 10.1002/Jcp.1041340313  0.446
1988 Goris J, Pallen CJ, Parker PJ, Hermann J, Waterfield MD, Merlevede W. Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase. The Biochemical Journal. 256: 1029-34. PMID 2852001 DOI: 10.1042/Bj2561029  0.367
1987 Bajaj M, Waterfield MD, Schlessinger J, Taylor WR, Blundell T. On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 916: 220-226. PMID 3676333 DOI: 10.1016/0167-4838(87)90112-9  0.366
1987 Berger MS, Gullick WJ, Greenfield C, Evans S, Addis BJ, Waterfield MD. Epidermal growth factor receptors in lung tumours. The Journal of Pathology. 152: 297-307. PMID 3668732 DOI: 10.1002/Path.1711520408  0.33
1987 Berger MS, Greenfield C, Gullick WJ, Haley J, Downward J, Neal DE, Harris AL, Waterfield MD. Evaluation of epidermal growth factor receptors in bladder tumours. British Journal of Cancer. 56: 533-7. PMID 3426916 DOI: 10.1038/Bjc.1987.238  0.504
1987 Gullick WJ, Berger MS, Bennett PL, Rothbard JB, Waterfield MD. Expression of the c-erbB-2 protein in normal and transformed cells. International Journal of Cancer. 40: 246-54. PMID 3301694 DOI: 10.1002/Ijc.2910400221  0.379
1986 Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways Science. 233: 859-866. PMID 3755548 DOI: 10.1126/Science.3755548  0.315
1986 Parker PJ, Coussens L, Totty N, Rhee L, Young S, Chen E, Stabel S, Waterfield MD, Ullrich A. The complete primary structure of protein kinase C - The major phorbol ester receptor Science. 233: 853-859. PMID 3755547 DOI: 10.1126/Science.3755547  0.34
1986 Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J. Sequence and expression of human estrogen receptor complementary DNA. Science (New York, N.Y.). 231: 1150-4. PMID 3753802 DOI: 10.1126/Science.3753802  0.371
1986 Ullrich A, Riedel H, Yarden Y, Coussens L, Gray A, Dull T, Schlessinger J, Waterfield MD, Parker PJ. Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C. Cold Spring Harbor Symposia On Quantitative Biology. 51: 713-24. PMID 3472757 DOI: 10.1101/Sqb.1986.051.01.084  0.471
1986 Gullick WJ, Downward J, Foulkes JG, Waterfield MD. Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. European Journal of Biochemistry. 158: 245-53. PMID 3015611 DOI: 10.1111/J.1432-1033.1986.Tb09744.X  0.64
1986 Kris RM, Lax I, Sasson I, Copf B, Werlin S, Gullick W, Waterfield MD, Ullrich A, Fridkin M, Schlessinger J. Synthetic peptide approach to the analysis of kinase activities of avian EGF receptor and v-erbB protein. Biochimie. 67: 1095-101. PMID 3000459 DOI: 10.1016/S0300-9084(85)80106-1  0.335
1985 Gullick WJ, Marsden JJ, Downward J, Waterfield MD. The use of anti-synthetic peptide antibodies to study the v-erb B protein from chicken and rat cells transformed by avian erythroblastosis virus Journal of Cell Science. 151-160. PMID 3914991 DOI: 10.1242/Jcs.1985.Supplement_3.15  0.501
1985 Parker PJ, Katan M, Waterfield MD, Leader DP. The phosphorylation of eukaryotic ribosomal protein S6 by protein kinase C European Journal of Biochemistry. 148: 579-586. PMID 3158521 DOI: 10.1111/J.1432-1033.1985.Tb08879.X  0.433
1985 Kris RM, Lax I, Gullick W, Waterfield MD, Ullrich A, Fridkin M, Schlessinger J. Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell. 40: 619-25. PMID 2982501 DOI: 10.1016/0092-8674(85)90210-7  0.407
1985 Gullick WJ, Downward J, Parker PJ, Whittle N, Kris R, Schlessinger J, Ullrich A, Waterfield MD. The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies. Proceedings of the Royal Society of London. Series B, Biological Sciences. 226: 127-34. PMID 2866520 DOI: 10.1098/Rspb.1985.0087  0.547
1985 Gullick WJ, Downward J, Waterfield MD. Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function. The Embo Journal. 4: 2869-77. PMID 2415353 DOI: 10.1002/J.1460-2075.1985.Tb04016.X  0.559
1985 Downward J, Waterfield MD, Parker PJ. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. Journal of Biological Chemistry. 260: 14538-14546. DOI: 10.1016/s0021-9258(17)38602-7  0.569
1985 Stroobant P, Gullick W, Waterfield M, Rozengurt E. Highly purified fibroblast-derived growth factor, an SV40-transformed fibroblast-secreted mitogen, is closely related to platelet-derived growth factor. The Embo Journal. 4: 1945-1949. DOI: 10.1002/J.1460-2075.1985.Tb03875.X  0.334
1984 Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 307: 521-7. PMID 6320011 DOI: 10.1038/307521A0  0.535
1984 Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 311: 483-5. PMID 6090945 DOI: 10.1038/311483A0  0.585
1983 Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson Å, Westermark B, Heldin C, Huang JS, Deuel TF. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature. 304: 35-39. PMID 6306471 DOI: 10.1038/304035A0  0.336
1980 Koszinowski UH, Allen H, Gething MJ, Waterfield MD, Klenk HD. Recognition of viral glycoproteins by influenza A-specific cross-reactive cytolytic T lymphocytes. The Journal of Experimental Medicine. 151: 945-58. PMID 6154763 DOI: 10.1084/Jem.151.4.945  0.305
1979 Koszinowski U, Gething M, Waterfield M. Analysis Of Requirements For Cell Mediated Lysis Interaction Between Viral Glycoproteins And Cell Plasma Membranes Cell Biology and Immunology of Leukocyte Function. 849-856. DOI: 10.1016/B978-0-12-569650-0.50109-1  0.321
1978 Gething MJ, Koszinowski U, Waterfield M. Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity Nature. 274: 689-691. PMID 209339 DOI: 10.1038/274689A0  0.303
1977 Koszinowski U, Gething MJ, Waterfield M. T-cell cytotoxicity in the absence of viral protein synthesis in target cells. Nature. 267: 160-3. PMID 16073430 DOI: 10.1038/267160A0  0.329
1971 Waterfield MD, Corbett C, Haber E. A protein sequencing device of simple construction. Analytical Biochemistry. 38: 475-92. PMID 5493071 DOI: 10.1016/0003-2697(70)90473-2  0.385
1971 Jaton JC, Waterfield MD, Margolies MN, Bloch KJ, Haber E. Variation in the primary structure of antibodies during the course of immunization. Biochemistry. 10: 1583-7. PMID 4103273 DOI: 10.1021/bi00785a012  0.336
1970 Waterfield M, Haber E. Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography. Biochemistry. 9: 832-9. PMID 5461406 DOI: 10.1021/Bi00806A016  0.347
1970 Jaton JC, Waterfield MD, Margolies MN, Haber E. Isolation and characterization of structurally homogeneous antibodies from antipneumococcal sera. Proceedings of the National Academy of Sciences of the United States of America. 66: 959-66. PMID 4393268 DOI: 10.1073/Pnas.66.3.959  0.382
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