Giuseppe Melacini, PhD - Publications

Affiliations: 
Chemistry and Chemical Biology McMaster University, Hamilton, ON, Canada 
Area:
NMR Spectroscopy, Protein Structure, Dynamics
Website:
http://www.chemistry.mcmaster.ca/melacini/

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ahmed A, Boulton S, Shao H, Akimoto M, Natarajan A, Cheng X, Melacini G. Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective. Cells. 8. PMID 31752286 DOI: 10.3390/cells8111462  0.64
2019 Ahmed R, Akcan M, Khondker A, Rheinstädter MC, Bozelli JC, Epand RM, Huynh V, Wylie RG, Boulton S, Huang J, Verschoor CP, Melacini G. Atomic resolution map of the soluble amyloid beta assembly toxic surfaces. Chemical Science. 10: 6072-6082. PMID 31360412 DOI: 10.1039/c9sc01331h  0.52
2019 Boulton S, Selvaratnam R, Ahmed R, Van K, Cheng X, Melacini G. Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Journal of Medicinal Chemistry. PMID 31074269 DOI: 10.1021/acs.jmedchem.9b00258  0.8
2018 Boulton S, Selvaratnam R, Blondeau JP, Lezoualc'h F, Melacini G. Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist. Journal of the American Chemical Society. PMID 30016089 DOI: 10.1021/jacs.8b05044  0.8
2018 Ahmed R, Melacini G. A solution NMR toolset to probe the molecular mechanisms of amyloid inhibitors. Chemical Communications (Cambridge, England). PMID 29658548 DOI: 10.1039/c8cc01380b  0.36
2018 Baid K, Nellimarla S, Huynh A, Boulton S, Guarné A, Melacini G, Collins SE, Mossman KL. Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors. Immunology and Cell Biology. PMID 29617041 DOI: 10.1111/imcb.12052  0.52
2018 VanSchouwen B, Melacini G. Role of Dimers in the cAMP-Dependent Activation of Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels. The Journal of Physical Chemistry. B. PMID 29461059 DOI: 10.1021/acs.jpcb.7b10125  0.8
2018 Akimoto M, VanSchouwen B, Melacini G. The Structure of the Apo cAMP-Binding Domain of HCN4: A Stepping Stone towards Understanding the cAMP-Dependent Modulation of the Hyperpolarization-Activated Cyclic-Nucleotide-Gated (HCN) Ion Channels. The Febs Journal. PMID 29444387 DOI: 10.1111/febs.14408  0.8
2018 Nguyen Y, Boulton S, McNicholl ET, Akimoto M, Harvey H, Aidoo F, Melacini G, Burrows LL. A highly dynamic loop of the Pseudomonas aeruginosa PA14 type IV pilin is essential for pilus assembly. Acs Infectious Diseases. PMID 29342354 DOI: 10.1021/acsinfecdis.7b00229  0.64
2018 Boulton S, Selvaratnam R, Ahmed R, Melacini G. Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist's Approach to Allostery. Methods in Molecular Biology (Clifton, N.J.). 1688: 391-405. PMID 29151219 DOI: 10.1007/978-1-4939-7386-6_18  0.8
2017 VanSchouwen B, Ahmed R, Milojevic J, Melacini G. Functional dynamics in cyclic nucleotide signaling and amyloid inhibition. Biochimica Et Biophysica Acta. PMID 28911813 DOI: 10.1016/j.bbapap.2017.09.005  1
2017 Ahmed R, VanSchouwen B, Jafari N, Ni X, Ortega J, Melacini G. Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers. Journal of the American Chemical Society. PMID 28841302 DOI: 10.1021/jacs.7b05012  0.8
2017 Algamal M, Ahmed R, Jafari N, Ahsan B, Ortega J, Melacini G. Atomic-Resolution Map of the Interactions between an Amyloid Inhibitor Protein and Amyloid Beta (Aβ) Peptides in the Monomer and Protofibril States. The Journal of Biological Chemistry. PMID 28798235 DOI: 10.1074/jbc.M117.792853  0.52
2017 VanSchouwen B, Melacini G. Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides. Handbook of Experimental Pharmacology. PMID 28181007 DOI: 10.1007/164_2016_5006  0.8
2017 Boulton S, Akimoto M, Akbarizadeh S, Melacini G. Free Energy Landscape Remodeling of the Cardiac Pacemaker Channel Explains the Molecular Basis of Familial Sinus Bradycardia. The Journal of Biological Chemistry. PMID 28174302 DOI: 10.1074/jbc.M116.773697  0.64
2016 Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of PKG Iβ CNB-B:Rp-cGMPS complex reveals an apo-like, inactive conformation. Febs Letters. PMID 27914169 DOI: 10.1002/1873-3468.12505  0.8
2016 VanSchouwen B, Melacini G. Structural Basis of Tonic Inhibition by Dimers of Dimers in Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels. The Journal of Physical Chemistry. B. PMID 27690448 DOI: 10.1021/acs.jpcb.6b07735  0.8
2016 Almawi AW, Matthews LA, Larasati, Myrox P, Boulton S, Lai C, Moraes T, Melacini G, Ghirlando R, Duncker BP, Guarné A. 'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7. Scientific Reports. 6: 34237. PMID 27681475 DOI: 10.1038/srep34237  0.52
2016 VanSchouwen B, Melacini G. Cracking the allosteric code of NMR chemical shifts. Proceedings of the National Academy of Sciences of the United States of America. 113: 9407-9. PMID 27512035 DOI: 10.1073/pnas.1611068113  0.8
2016 Jafari N, Ahmed R, Gloyd M, Bloomfield J, Britz-McKibbin P, Melacini G. Allosteric Sensing of Fatty Acid Binding by NMR: Application to Human Serum Albumin. Journal of Medicinal Chemistry. PMID 27429126 DOI: 10.1021/acs.jmedchem.6b00410  1
2016 Boulton S, Melacini G. Advances in NMR Methods To Map Allosteric Sites: From Models to Translation. Chemical Reviews. PMID 27111288 DOI: 10.1021/acs.chemrev.5b00718  0.52
2015 Byun JA, Melacini G. Disordered Regions Flanking Ordered Domains Modulate Signaling Transduction. Biophysical Journal. 109: 2447-8. PMID 26682801 DOI: 10.1016/j.bpj.2015.10.030  1
2015 Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα. Plos Biology. 13: e1002305. PMID 26618408 DOI: 10.1371/journal.pbio.1002305  0.92
2015 VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). The Journal of Biological Chemistry. PMID 26370085 DOI: 10.1074/jbc.M115.685305  1
2015 Tomaselli S, Pagano K, Boulton S, Zanzoni S, Melacini G, Molinari H, Ragona L. Lipid binding protein response to a bile acid library: a combined NMR and statistical approach. The Febs Journal. PMID 26260520 DOI: 10.1111/febs.13405  1
2015 Moleschi KJ, Akimoto M, Melacini G. Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR. Journal of the American Chemical Society. PMID 26247242 DOI: 10.1021/jacs.5b06557  1
2015 Fogolari F, Corazza A, Fortuna S, Soler MA, VanSchouwen B, Brancolini G, Corni S, Melacini G, Esposito G. Distance-Based Configurational Entropy of Proteins from Molecular Dynamics Simulations. Plos One. 10: e0132356. PMID 26177039 DOI: 10.1371/journal.pone.0132356  1
2015 VanSchouwen B, Akimoto M, Sayadi M, Fogolari F, Melacini G. Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels. The Journal of Biological Chemistry. 290: 17642-54. PMID 25944904 DOI: 10.1074/jbc.M115.651877  0.8
2015 Zhu Y, Chen H, Boulton S, Mei F, Ye N, Melacini G, Zhou J, Cheng X. Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window". Scientific Reports. 5: 9344. PMID 25791905 DOI: 10.1038/srep09344  1
2015 Vanschouwen B, Akimoto M, Sayadi M, Fogolari F, Melacini G. Roe of dynamics in the autoinhibition and activation of the hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels Journal of Biological Chemistry. 290: 17642-17654. DOI: 10.1074/jbc.M115.651877  1
2014 Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. A tool set to map allosteric networks through the NMR chemical shift covariance analysis. Scientific Reports. 4: 7306. PMID 25482377 DOI: 10.1038/srep07306  0.8
2014 Moleschi K, Melacini G. Signaling at crossroads: The dialogue between PDEs and PKA is spoken in multiple languages Biophysical Journal. 107: 1259-1260. PMID 25229132 DOI: 10.1016/j.bpj.2014.07.051  1
2014 Akimoto M, Zhang Z, Boulton S, Selvaratnam R, Van Schouwen B, Gloyd M, Accili EA, Lange OF, Melacini G. A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP Journal of Biological Chemistry. 289: 22205-22220. PMID 24878962 DOI: 10.1074/jbc.M114.572164  1
2014 Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR. Biochemical Society Transactions. 42: 302-7. PMID 24646235 DOI: 10.1042/BST20130282  1
2014 Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Allosteric linkers in cAMP signalling. Biochemical Society Transactions. 42: 139-44. PMID 24450641 DOI: 10.1042/BST20130257  1
2014 Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A. A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. The Journal of Biological Chemistry. 289: 2589-99. PMID 24285546 DOI: 10.1074/jbc.M113.517060  1
2014 Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG i Structure. 22: 116-124. PMID 24239458 DOI: 10.1016/j.str.2013.09.021  1
2014 Milojevic J, Costa M, Ortiz AM, Jorquera JI, Melacini G. In vitro amyloid-β binding and inhibition of amyloid-β self-association by therapeutic albumin Journal of Alzheimer's Disease. 38: 753-765. PMID 24072068 DOI: 10.3233/JAD-131169  1
2014 Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G. A tool set to map allosteric networks through the NMR chemical shift covariance analysis Scientific Reports. 4. DOI: 10.1038/srep07306  1
2013 Algamal M, Milojevic J, Jafari N, Zhang W, Melacini G. Mapping the Interactions between the Alzheimer's Aβ-Peptide and human serum albumin beyond domain resolution Biophysical Journal. 105: 1700-1709. PMID 24094411 DOI: 10.1016/j.bpj.2013.08.025  1
2013 Son I, Selvaratnam R, Dubins DN, Melacini G, Chalikian TV. Ultrasonic and densimetric characterization of the association of cyclic AMP with the cAMP-binding domain of the exchange protein EPAC1 Journal of Physical Chemistry B. 117: 10779-10784. PMID 23968295 DOI: 10.1021/jp406451p  1
2013 Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14231-6. PMID 23946424 DOI: 10.1073/pnas.1312644110  1
2013 Raditsis AV, Milojevic J, Melacini G. Aβ association inhibition by transferrin Biophysical Journal. 105: 473-480. PMID 23870268 DOI: 10.1016/j.bpj.2013.03.065  1
2013 Barker CA, Allison SE, Zlitni S, Nguyen ND, Das R, Melacini G, Capretta AA, Brown ED. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorganic & Medicinal Chemistry Letters. 23: 2426-31. PMID 23473681 DOI: 10.1016/j.bmcl.2013.02.005  1
2012 Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G. The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR Plos One. 7. PMID 23185272 DOI: 10.1371/journal.pone.0048707  1
2012 Selvaratnam R, Vanschouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants Biophysical Journal. 102: 630-639. PMID 22325287 DOI: 10.1016/j.bpj.2011.12.030  1
2012 Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. cAMP-dependent allostery and dynamics in Epac: An NMR view Biochemical Society Transactions. 40: 219-223. PMID 22260694 DOI: 10.1042/BST20110628  1
2011 VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G. Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) Journal of Biological Chemistry. 286: 42655-42669. PMID 21873431 DOI: 10.1074/jbc.M111.277723  1
2011 Selvaratnam R, Chowdhury S, VanSchouwena B, Melacini G. Mapping allostery through the covariance analysis of NMR chemical shifts Proceedings of the National Academy of Sciences of the United States of America. 108: 6133-6138. PMID 21444788 DOI: 10.1073/pnas.1017311108  1
2011 Milojevic J, Melacini G. Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions Biophysical Journal. 100: 183-192. PMID 21190670 DOI: 10.1016/j.bpj.2010.11.037  1
2010 McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. The Journal of Biological Chemistry. 285: 15523-37. PMID 20202931 DOI: 10.1074/jbc.M110.105783  1
2009 Milojevic J, Raditsis A, Melacini G. Human serum albumin inhibits Aβ fibrillization through a "monomer-competitor" mechanism Biophysical Journal. 97: 2585-2594. PMID 19883602 DOI: 10.1016/j.bpj.2009.08.028  1
2009 Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting Nature Chemical Biology. 5: 849-856. PMID 19783991 DOI: 10.1038/nchembio.221  1
2009 Kooistra J, Milojevic J, Melacini G, Ortega J. A new function of human htra2 as an amyloid-β oligomerization inhibitor Journal of Alzheimer's Disease. 17: 281-294. PMID 19502709 DOI: 10.3233/JAD-2009-1037  1
2009 Das R, Chowdhury S, Mazhab-Jafari MT, SilDas S, Selvaratnam R, Melacini G. Dynamically driven ligand selectivity in cyclic nucleotide binding domains Journal of Biological Chemistry. 284: 23682-23696. PMID 19403523 DOI: 10.1074/jbc.M109.011700  1
2009 Gavina JMA, Mazhab-Jafari MT, Melacini G, Britz-McKibbin P. Label-free assay for thermodynamic analysis of protein-ligand interactions: A multivariate strategy for allosteric ligand screening Biochemistry. 48: 223-225. PMID 19113833 DOI: 10.1021/bi802121g  1
2008 Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G. Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP Journal of Biological Chemistry. 283: 19691-19703. PMID 18411261 DOI: 10.1074/jbc.M802164200  1
2008 Huang H, Milojevic J, Melacini G. Analysis and optimization of saturation transfer difference NMR experiments designed to map early self-association events in amyloidogenic peptides. The Journal of Physical Chemistry. B. 112: 5795-802. PMID 18410162 DOI: 10.1021/jp7118718  1
2008 Huang H, Milojevic J, Melacini G. Analysis and optimization of saturation transfer difference NMR experiments designed to map early self-association events in amyloidogenic peptides Journal of Physical Chemistry B. 112: 5795-5802. DOI: 10.1021/jp7118718  1
2007 Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G. Understanding cAMP-dependent allostery by NMR spectroscopy: Comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states Journal of the American Chemical Society. 129: 14482-14492. PMID 17973384 DOI: 10.1021/ja0753703  1
2007 Abu-Abed M, Das R, Wang L, Melacini G. Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIα Proteins: Structure, Function and Genetics. 69: 112-124. PMID 17596845 DOI: 10.1002/prot.21446  1
2007 Milojevic J, Esposito V, Das R, Melacini G. Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance relaxation NMR spectroscopy Journal of the American Chemical Society. 129: 4282-4290. PMID 17367135 DOI: 10.1021/ja067367+  1
2007 Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. cAMP activation of PKA defines an ancient signaling mechanism Proceedings of the National Academy of Sciences of the United States of America. 104: 93-98. PMID 17182741 DOI: 10.1073/pnas.0609033103  1
2007 Das R, Melacini G. A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain Journal of Biological Chemistry. 282: 581-593. PMID 17074757 DOI: 10.1074/jbc.M607706200  1
2006 Huang H, Melacini G. High-resolution protein hydration NMR experiments: probing how protein surfaces interact with water and other non-covalent ligands. Analytica Chimica Acta. 564: 1-9. PMID 17723356 DOI: 10.1016/j.aca.2005.10.049  0.72
2006 Milojevic J, Esposito V, Das R, Melacini G. Analysis and parametric optimization of 1H off-resonance relaxation NMR experiments designed to map polypeptide self-recognition and other noncovalent interactions. The Journal of Physical Chemistry. B. 110: 20664-70. PMID 17034257 DOI: 10.1021/jp063194z  1
2006 Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit [62] Journal of Biomolecular Nmr. 36: 64. PMID 17016670 DOI: 10.1007/s10858-006-9050-9  1
2006 Das R, Abu-Abed M, Melacini G. Mapping allostery through equilibrium perturbation NMR spectroscopy Journal of the American Chemical Society. 128: 8406-8407. PMID 16802799 DOI: 10.1021/ja060046d  1
2006 Milojevic J, Esposito V, Das R, Melacini G. Analysis and parametric optimization of1H off-resonance relaxation NMR experiments designed, to map polypeptide self-recognition and other noncovalent interactions Journal of Physical Chemistry B. 110: 20664-20670. DOI: 10.1021/jp063194z  1
2006 Huang H, Melacini G. High-resolution protein hydration NMR experiments: Probing how protein surfaces interact with water and other non-covalent ligands Analytica Chimica Acta. 564: 1-9. DOI: 10.1016/j.aca.2005.10.049  1
2006 Melacini G. Protein / ligand interactions by NMR Chimica Oggi. 24: 59-60.  1
2005 Esposito V, Das R, Melacini G. Mapping polypeptide self-recognition through 1H off-resonance relaxation Journal of the American Chemical Society. 127: 9358-9359. PMID 15984849 DOI: 10.1021/ja051714i  1
2005 Prieto JH, Sampoli Benitez BA, Melacini G, Johnson DA, Wood MJ, Komives EA. Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. Biochemistry. 44: 1225-33. PMID 15667216 DOI: 10.1021/bi0478852  1
2004 Rodríguez JC, Jennings PA, Melacini G. Using chemical exchange to assign non-covalent protein complexes in slow exchange with the free state: enhanced resolution and efficient signal editing. Journal of Biomolecular Nmr. 30: 155-61. PMID 15557802 DOI: 10.1023/B:JNMR.0000048857.44219.c3  1
2004 Plesniak LA, Parducho JI, Ziebart A, Geierstanger BH, Whiles JA, Melacini G, Jennings PA. Orientation and helical conformation of a tissue-specific hunter-killer peptide in micelles. Protein Science : a Publication of the Protein Society. 13: 1988-96. PMID 15273301 DOI: 10.1110/ps.04853204  1
2004 Epand RM, Epand RF, Sayer BG, Melacini G, Palgulachari MN, Segrest JP, Anantharamaiah GM. An Apolipoprotein AI Mimetic Peptide: Membrane Interactions and the Role of Cholesterol Biochemistry. 43: 5073-5083. PMID 15109266 DOI: 10.1021/bi049786u  1
2003 Wood MJ, Becvar LA, Prieto JH, Melacini G, Komives EA. NMR structures reveal how oxidation inactivates thrombomodulin. Biochemistry. 42: 11932-42. PMID 14556624 DOI: 10.1021/bi034646q  1
2003 Fayos R, Melacini G, Newlon MG, Burns L, Scott JD, Jennings PA. Induction of flexibility through protein-protein interactions. The Journal of Biological Chemistry. 278: 18581-7. PMID 12604595 DOI: 10.1074/jbc.M300866200  1
2002 Rodríguez JC, Jennings PA, Melacini G. Effect of chemical exchange on radiation damping in aqueous solutions of the osmolyte glycine Journal of the American Chemical Society. 124: 6240-6241. PMID 12033843 DOI: 10.1021/ja0256966  1
2002 Glover KJ, Whiles JA, Vold RR, Melacini G. Position of residues in transmembrane peptides with respect to the lipid bilayer: a combined lipid Noes and water chemical exchange approach in phospholipid bicelles. Journal of Biomolecular Nmr. 22: 57-64. PMID 11885981 DOI: 10.1023/A:1013817818794  1
2001 Glover KJ, Whiles JA, Wood MJ, Melacini G, Komives EA, Vold RR. Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles. Biochemistry. 40: 13137-42. PMID 11683621 DOI: 10.1021/bi011485m  1
2001 Whiles JA, Brasseur R, Glover KJ, Melacini G, Komives EA, Vold RR. Orientation and effects of mastoparan X on phospholipid bicelles. Biophysical Journal. 80: 280-93. PMID 11159401 DOI: 10.1016/S0006-3495(01)76013-4  1
2000 Melacini G, Bonvin AM, Goodman M, Boelens R, Kaptein R. Hydration dynamics of the collagen triple helix by NMR. Journal of Molecular Biology. 300: 1041-9. PMID 10903852 DOI: 10.1006/jmbi.2000.3919  1
2000 Melacini G. Separation of intra- and intermolecular NOEs through simultaneous editing and J-compensated filtering: A 4D quadrature-free constant-time J-resolved approach Journal of the American Chemical Society. 122: 9735-9738. DOI: 10.1021/ja0015996  1
2000 Goodman M, Kwak J, Locardi E, Melacini G. Synthesis and biophysics of triple helical collagen mimetics American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 41: 920-921.  1
1999 Melacini G, Boelens R, Kaptein R. Band-selective editing of exchange-relay in protein-water NOE experiments. Journal of Biomolecular Nmr. 13: 67-71. PMID 21080264 DOI: 10.1023/A:1008350918005  1
1999 Melacini G, Boelens R, Kaptein R. Water-macromolecule interactions by NMR: a quadrature-free constant-time approach and its application to CI2. Journal of Biomolecular Nmr. 15: 189-201. PMID 10677822  1
1999 Spronk CA, Bonvin AM, Radha PK, Melacini G, Boelens R, Kaptein R. The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator. Structure (London, England : 1993). 7: 1483-92. PMID 10647179  1
1999 Nooren IM, Rietveld AW, Melacini G, Sauer RT, Kaptein R, Boelens R. The solution structure and dynamics of an Arc repressor mutant reveal premelting conformational changes related to DNA binding. Biochemistry. 38: 6035-42. PMID 10320329 DOI: 10.1021/bi982677t  1
1999 Melacini G, Kaptein R, Boelens R. Editing of chemical exchange-relayed NOEs in NMR experiments for the observation of protein-water interactions. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 136: 214-8. PMID 9986764 DOI: 10.1006/jmre.1998.1646  1
1998 Melacini G, Goodman M. Improved method for the stereospecific 1H-NMR assignments in collagen- like triple-helices Chirality. 10: 28-34.  1
1997 Melacini G, Feng Y, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): conformational analysis of Gly-Nleu-Pro sequences by 1H-NMR and molecular modeling. Biochemistry. 36: 8725-32. PMID 9220959 DOI: 10.1021/bi962981r  1
1997 Feng Y, Melacini G, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): synthesis and biophysical studies of Gly-Nleu-Pro sequences by circular dichroism and optical rotation. Biochemistry. 36: 8716-24. PMID 9220958 DOI: 10.1021/bi962980z  1
1997 Melacini G, Zhu Q, Osapay G, Goodman M. A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs. Journal of Medicinal Chemistry. 40: 2252-8. PMID 9216844 DOI: 10.1021/jm960851a  1
1997 Osapay G, Prokai L, Kim HS, Medzihradszky KF, Coy DH, Liapakis G, Reisine T, Melacini G, Zhu Q, Wang SH, Mattern RH, Goodman M. Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies. Journal of Medicinal Chemistry. 40: 2241-51. PMID 9216843 DOI: 10.1021/jm960850i  1
1997 Melacini G, Zhu Q, Goodman M. Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures. Biochemistry. 36: 1233-41. PMID 9063871 DOI: 10.1021/bi962497o  1
1996 Feng Y, Melacini G, Taulane JP, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu): synthesis and biophysical studies of Gly-Pro-Nleu sequences by circular dichroism, ultraviolet absorbance, and optical rotation. Biopolymers. 39: 859-72. PMID 8946805 DOI: 10.1002/(SICI)1097-0282(199612)39:6<859::AID-BIP10>3.0.CO;2-Z  1
1996 Melacini G, Feng Y, Goodman M. Collagen-based structures containing the peptoid residue N-isobutylglycine (Nleu). 6. Conformational analysis of Gly-Pro-Nleu sequences by 1H NMR, CD, and molecular modeling Journal of the American Chemical Society. 118: 10725-10732. DOI: 10.1021/ja9617193  1
1996 Goodman M, Melacini G, Feng Y. Collagen-like triple helices incorporating peptoid residues Journal of the American Chemical Society. 118: 10928-10929. DOI: 10.1021/ja961717i  1
1996 Melacini G, Feng Y, Goodman M. Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 3. Conformational analysis by 1H-NMR and molecular modeling studies Journal of the American Chemical Society. 118: 10359-10364. DOI: 10.1021/ja9612615  1
1996 Feng Y, Melacini G, Taulane JP, Goodman M. Acetyl-terminated and template-assembled collagen-based polypeptides composed of Gly-Pro-Hyp sequences. 2. Synthesis and conformational analysis by circular dichroism, ultraviolet absorbance, and optical rotation Journal of the American Chemical Society. 118: 10351-10358. DOI: 10.1021/ja961260c  1
1996 Goodman M, Feng Y, Melacini G, Taulane JP. A template-induced incipient collagen-like triple-helical structure Journal of the American Chemical Society. 118: 5156-5157. DOI: 10.1021/ja954132h  1
1994 Ösapay G, Melacini G, Zhu Q, Tehrani L, Goodman M. Synthesis and physicochemical characterization of the lanthionine analog of somatostatin[1-14] Letters in Peptide Science. 1: 81-87. DOI: 10.1007/BF00126277  1
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