Zandrea Ambrose, Ph.D. - Publications

2001 University of Washington, Seattle, Seattle, WA 
Immunology, Microbiology Biology, Public Health

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ingram Z, Kline C, Hughson AK, Singh PK, Fischer HL, Sowd GA, Watkins SC, Kane M, Engelman AN, Ambrose Z. Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration. Biorxiv : the Preprint Server For Biology. PMID 38645162 DOI: 10.1101/2024.04.08.588584  0.437
2023 Elizaldi SR, Verma A, Ma ZM, Ott S, Rajasundaram D, Hawes CE, Lakshmanappa YS, Cottrell ML, Kashuba ADM, Ambrose Z, Lifson JD, Morrison JH, Iyer SS. Deep analysis of CD4 T cells in the rhesus CNS during SIV infection. Plos Pathogens. 19: e1011844. PMID 38060615 DOI: 10.1371/journal.ppat.1011844  0.414
2023 Roy CN, Shu ST, Kline C, Rigatti L, Smithgall TE, Ambrose Z. Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission. Scientific Reports. 13: 17067. PMID 37816950 DOI: 10.1038/s41598-023-44366-2  0.348
2023 Elizaldi SR, Verma A, Ma ZM, Ott S, Rajasundaram D, Cottrell ML, Kashuba ADM, Ambrose Z, Lifson JD, Morrison JH, Iyer SS. CD4 T cell Responses in the CNS during SIV infection. Biorxiv : the Preprint Server For Biology. PMID 37662237 DOI: 10.1101/2023.08.24.554055  0.425
2022 Dwivedi R, Wang Y, Kline C, Fischer DK, Ambrose Z. APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants. Frontiers in Virology. 2. PMID 35957953 DOI: 10.3389/fviro.2022.919825  0.494
2021 Tisthammer KH, Kline C, Rutledge T, Diedrich CR, Ita S, Lin PL, Ambrose Z, Pennings PS. SIV Evolutionary Dynamics in Cynomolgus Macaques during SIV- Co-Infection. Viruses. 14. PMID 35062252 DOI: 10.3390/v14010048  0.422
2021 Ingram Z, Fischer DK, Ambrose Z. Disassembling the Nature of Capsid: Biochemical, Genetic, and Imaging Approaches to Assess HIV-1 Capsid Functions. Viruses. 13. PMID 34835043 DOI: 10.3390/v13112237  0.5
2021 Roy CN, Benitez Moreno MA, Kline C, Ambrose Z. CG dinucleotide removal in bioluminescent and fluorescent reporters improves HIV-1 replication and reporter gene expression for dual imaging in humanized mice. Journal of Virology. JVI0044921. PMID 34232063 DOI: 10.1128/JVI.00449-21  0.513
2021 Zhong Z, Ning J, Boggs EA, Jang S, Wallace C, Telmer C, Bruchez MP, Ahn J, Engelman AN, Zhang P, Watkins SC, Ambrose Z. Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner. Mbio. 12. PMID 33758083 DOI: 10.1128/mBio.03142-20  0.554
2020 Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. Plos Biology. 18: e3001015. PMID 33332391 DOI: 10.1371/journal.pbio.3001015  0.42
2020 Diedrich CR, Rutledge T, Maiello P, Baranowski TM, White AG, Borish HJ, Karell P, Hopkins F, Brown J, Fortune SM, Flynn JL, Ambrose Z, Lin PL. SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis. Plos Pathogens. 16: e1008413. PMID 32730321 DOI: 10.1371/Journal.Ppat.1008413  0.41
2020 Melody K, Roy CN, Kline C, Cottrell ML, Evans D, Shutt K, Pennings PS, Keele BF, Bility M, Kashuba ADM, Ambrose Z. Long-acting rilpivirine (RPV LA) pre-exposure prophylaxis does not inhibit vaginal transmission of RPV-resistant HIV-1 nor select for high frequency drug resistance in humanized mice. Journal of Virology. PMID 31969438 DOI: 10.1128/Jvi.01912-19  0.565
2019 Fu X, Ning J, Zhong Z, Ambrose Z, Charles Watkins S, Zhang P. AutoCLEM: An Automated Workflow for Correlative Live-Cell Fluorescence Microscopy and Cryo-Electron Tomography. Scientific Reports. 9: 19207. PMID 31844138 DOI: 10.1038/S41598-019-55766-8  0.312
2019 Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. A novel phenotype links HIV-1 capsid stability to cGAS-mediated DNA sensing. Journal of Virology. PMID 31167922 DOI: 10.1128/Jvi.00706-19  0.454
2019 Boyer PL, Melody K, Smith SJ, Dunn LL, Kline C, Fischer DK, Dwivedi R, Clark P, Hughes SH, Ambrose Z. Two Co-Selected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Non-nucleoside RT Inhibitors and Nucleoside Analogs. Journal of Virology. PMID 30894467 DOI: 10.1128/Jvi.00224-19  0.423
2019 Fischer DK, Saito A, Kline C, Cohen R, Watkins SC, Yamashita M, Ambrose Z. CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes. Journal of Virology. PMID 30814280 DOI: 10.1128/Jvi.00214-19  0.594
2018 Ning J, Zhong Z, Fischer DK, Harris G, Watkins SC, Ambrose Z, Zhang P. Truncated CPSF6 forms higher order complexes that bind and disrupt HIV-1 capsid. Journal of Virology. PMID 29643241 DOI: 10.1128/Jvi.00368-18  0.573
2017 Akiyama H, Ramirez NP, Gibson G, Kline C, Watkins S, Ambrose Z, Gummuluru S. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of IFN-α. Journal of Virology. PMID 28794041 DOI: 10.1128/Jvi.00972-17  0.52
2017 Feder AF, Kline C, Polacino P, Cottrell M, Kashuba ADM, Keele BF, Hu SL, Petrov DA, Pennings PS, Ambrose Z. A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host. Plos Pathogens. 13: e1006358. PMID 28542550 DOI: 10.1371/Journal.Ppat.1006358  0.543
2016 Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. Journal of Virology. 90: 8059-73. PMID 27356901 DOI: 10.1128/Jvi.00553-16  0.547
2016 Smith SJ, Pauly GT, Akram A, Melody K, Ambrose Z, Schneider JP, Hughes SH. Rilpivirine and Doravirine have complementary efficacies against NNRTI-Resistant HIV-1 mutants. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 27124362 DOI: 10.1097/Qai.0000000000001031  0.516
2016 Smith SJ, Pauly GT, Akram A, Melody K, Rai G, Maloney DJ, Ambrose Z, Thomas CJ, Schneider JT, Hughes SH. Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants. Retrovirology. 13: 11. PMID 26880034 DOI: 10.1186/S12977-016-0244-2  0.512
2015 Kearney MF, Anderson EM, Coomer C, Smith L, Shao W, Johnson N, Kline C, Spindler J, Mellors JW, Coffin JM, Ambrose Z. Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy. Retrovirology. 12: 93. PMID 26559632 DOI: 10.1186/S12977-015-0212-2  0.434
2015 Melody K, McBeth S, Kline C, Kashuba AD, Mellors JW, Ambrose Z. Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase. Antimicrobial Agents and Chemotherapy. 59: 7762-70. PMID 26438501 DOI: 10.1128/Aac.01937-15  0.546
2015 Song J, Cai Z, White AG, Jin T, Wang X, Kadayakkara D, Anderson CJ, Ambrose Z, Young WB. Visualization and quantification of simian immunodeficiency virus (SIV)-infected cells using non-invasive molecular imaging. The Journal of General Virology. PMID 26297664 DOI: 10.1099/Jgv.0.000245  0.414
2014 Ambrose Z, Kline C, Polacino P, Hu SL. Dysregulation of multiple inflammatory molecules in lymph node and ileum of macaques during RT-SHIV infection with or without antiretroviral therapy. Journal of Medical Primatology. 43: 298-309. PMID 24784552 DOI: 10.1111/Jmp.12126  0.557
2014 Ambrose Z, Aiken C. HIV-1 uncoating: connection to nuclear entry and regulation by host proteins. Virology. 454: 371-9. PMID 24559861 DOI: 10.1016/J.Virol.2014.02.004  0.533
2014 Song J, Young W, Cai Z, Jin T, Wang X, Kadayakkara D, Anderson C, Ambrose Z. P-B3 Visualize and quantify simian immunodeficiency virus-infected cells in vivo Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 83. DOI: 10.1097/01.Qai.0000456183.19724.3F  0.407
2014 Zhang P, Jun S, Zhao G, Ambrose Z, Watkins SC. Correlative imaging and cryo-FIB processing for direct visualization of HIV-1 infection Microscopy and Microanalysis. 20: 974-975. DOI: 10.1017/S143192761400659X  0.398
2013 Kline C, Ndjomou J, Franks T, Kiser R, Coalter V, Smedley J, Piatak M, Mellors JW, Lifson JD, Ambrose Z. Persistence of viral reservoirs in multiple tissues after antiretroviral therapy suppression in a macaque RT-SHIV model. Plos One. 8: e84275. PMID 24367650 DOI: 10.1371/Journal.Pone.0084275  0.575
2013 Xu H, Franks T, Gibson G, Huber K, Rahm N, De Castillia CS, Luban J, Aiken C, Watkins S, Sluis-Cremer N, Ambrose Z. Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay. Retrovirology. 10: 70. PMID 23835323 DOI: 10.1186/1742-4690-10-70  0.564
2012 Boltz VF, Ambrose Z, Kearney MF, Shao W, Kewalramani VN, Maldarelli F, Mellors JW, Coffin JM. Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase. Journal of Virology. 86: 12525-30. PMID 22933296 DOI: 10.1128/Jvi.01963-12  0.534
2012 Acevedo O, Ambrose Z, Flaherty PT, Aamer H, Jain P, Sambasivarao SV. Identification of HIV inhibitors guided by free energy perturbation calculations. Current Pharmaceutical Design. 18: 1199-216. PMID 22316150 DOI: 10.2174/138920012799362828  0.545
2012 Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. Journal of Virology. 86: 4708-14. PMID 22301145 DOI: 10.1128/Jvi.05887-11  0.608
2011 Jun S, Ke D, Debiec K, Zhao G, Meng X, Ambrose Z, Gibson GA, Watkins SC, Zhang P. Direct visualization of HIV-1 with correlative live-cell microscopy and cryo-electron tomography. Structure (London, England : 1993). 19: 1573-81. PMID 22078557 DOI: 10.1016/J.Str.2011.09.006  0.557
2011 Kearney M, Spindler J, Shao W, Maldarelli F, Palmer S, Hu SL, Lifson JD, KewalRamani VN, Mellors JW, Coffin JM, Ambrose Z. Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy. Journal of Virology. 85: 1067-76. PMID 21084490 DOI: 10.1128/Jvi.01701-10  0.574
2010 Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host & Microbe. 7: 221-33. PMID 20227665 DOI: 10.1016/J.Chom.2010.02.007  0.556
2009 Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE. RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy. Retrovirology. 6: 101. PMID 19889213 DOI: 10.1186/1742-4690-6-101  0.561
2009 Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH. The nucleoside analogue D-carba T blocks HIV-1 reverse transcription. Journal of Medicinal Chemistry. 52: 5356-64. PMID 19678643 DOI: 10.1021/Jm801176E  0.525
2009 Hatziioannou T, Ambrose Z, Chung NP, Piatak M, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, et al. A macaque model of HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. 106: 4425-9. PMID 19255423 DOI: 10.1073/Pnas.0812587106  0.613
2009 Ambrose Z, Herman BD, Sheen CW, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N. The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. Journal of Virology. 83: 3826-33. PMID 19193782 DOI: 10.1128/Jvi.01968-08  0.48
2009 Lee K, Martin TD, Ambrose Z, Mulky A, KewalRamani VN. 117 CA-Dependent HIV-1 Nuclear Import Relies on Transportin-SR2 Jaids Journal of Acquired Immune Deficiency Syndromes. 51: 1. DOI: 10.1097/01.Qai.0000351074.66837.E3  0.441
2008 Ambrose Z, Compton L, Piatak M, Lu D, Alvord WG, Lubomirski MS, Hildreth JE, Lifson JD, Miller CJ, KewalRamani VN. Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges. Journal of Virology. 82: 6591-9. PMID 18434406 DOI: 10.1128/Jvi.02730-07  0.582
2008 Ambrose Z, KewalRamani VN. Of mice and monkeys: New advances in animal models to study HIV-1 therapy and prophylaxis Future Hiv Therapy. 2: 363-373. DOI: 10.2217/17469600.2.4.363  0.618
2007 Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, et al. Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy. Journal of Virology. 81: 12145-55. PMID 17855539 DOI: 10.1128/Jvi.01301-07  0.589
2007 Boyer PL, Julias JG, Ambrose Z, Siddiqui MA, Marquez VE, Hughes SH. The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants. Journal of Molecular Biology. 371: 873-82. PMID 17597154 DOI: 10.1016/J.Jmb.2007.05.043  0.461
2007 Ambrose Z, KewalRamani VN, Bieniasz PD, Hatziioannou T. HIV/AIDS: in search of an animal model. Trends in Biotechnology. 25: 333-7. PMID 17574286 DOI: 10.1016/J.Tibtech.2007.05.004  0.601
2007 Nissley DV, Radzio J, Ambrose Z, Sheen CW, Hamamouch N, Moore KL, Tachedjian G, Sluis-Cremer N. Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT. The Biochemical Journal. 404: 151-7. PMID 17286555 DOI: 10.1042/Bj20061814  0.464
2006 Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH. The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine. Journal of Virology. 80: 2578-81. PMID 16474164 DOI: 10.1128/Jvi.80.5.2578-2581.2006  0.535
2004 Ambrose Z, Boltz V, Palmer S, Coffin JM, Hughes SH, Kewalramani VN. In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques. Journal of Virology. 78: 13553-61. PMID 15564466 DOI: 10.1128/Jvi.78.24.13553-13561.2004  0.608
2003 Ambrose Z, Thompson J, Larsen K, Kuller L, Panicali DL, Clements JD, Agy M, Montefiori DC, Hu SL, Bosch ML. Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV(89.6). Virology. 308: 178-90. PMID 12706101 DOI: 10.1016/S0042-6822(03)00027-8  0.629
2001 Ambrose Z, Larsen K, Thompson J, Stevens Y, Finn E, Hu SL, Bosch ML. Evidence for early local viral replication and local production of antiviral immunity upon mucosal simian-human immunodeficiency virus SHIV(89.6) infection in Macaca nemestrina. Journal of Virology. 75: 8589-96. PMID 11507204 DOI: 10.1128/Jvi.75.18.8589-8596.2001  0.686
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