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Gregory M. Barton, Ph.D. - Publications

Affiliations: 
2000 University of Washington, Seattle, Seattle, WA 
Area:
Immunology, Molecular Biology
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Rael VE, Yano JA, Huizar JP, Slayden LC, Weiss MA, Turcotte EA, Terry JM, Zuo W, Thiffault I, Pastinen T, Farrow EG, Jenkins JL, Becker ML, Wong SC, Stevens AM, ... ... Barton GM, et al. Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans. The Journal of Experimental Medicine. 221. PMID 38780621 DOI: 10.1084/jem.20232005  0.364
2024 Carroll SL, Pasare C, Barton GM. Control of adaptive immunity by pattern recognition receptors. Immunity. 57: 632-648. PMID 38599163 DOI: 10.1016/j.immuni.2024.03.014  0.398
2021 Lind NA, Rael VE, Pestal K, Liu B, Barton GM. Regulation of the nucleic acid-sensing Toll-like receptors. Nature Reviews. Immunology. PMID 34272507 DOI: 10.1038/s41577-021-00577-0  0.407
2020 Stanbery AG, Newman ZR, Barton GM. Dysregulation of TLR9 in neonates leads to fatal inflammatory disease driven by IFN-γ. Proceedings of the National Academy of Sciences of the United States of America. 117: 3074-3082. PMID 31980536 DOI: 10.1073/pnas.1911579117  0.648
2019 Walsh CM, Hill RZ, Schwendinger-Schreck J, Deguine J, Brock EC, Kucirek N, Rifi Z, Wei J, Gronert K, Brem RB, Barton GM, Bautista DM. Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. Elife. 8. PMID 31631836 DOI: 10.7554/Elife.48448  0.565
2019 Majer O, Liu B, Woo BJ, Kreuk LSM, Van Dis E, Barton GM. Release from UNC93B1 reinforces the compartmentalized activation of select TLRs. Nature. PMID 31546247 DOI: 10.1038/S41586-019-1611-7  0.681
2019 Majer O, Liu B, Kreuk LSM, Krogan N, Barton GM. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. PMID 31546246 DOI: 10.1038/S41586-019-1612-6  0.689
2019 Kreuk LS, Koch MA, Slayden LC, Lind NA, Chu S, Savage HP, Kantor AB, Baumgarth N, Barton GM. B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota. Elife. 8. PMID 31433298 DOI: 10.7554/Elife.47015  0.617
2019 Ansaldo E, Slayden LC, Ching KL, Koch MA, Wolf NK, Plichta DR, Brown EM, Graham DB, Xavier RJ, Moon JJ, Barton GM. induces intestinal adaptive immune responses during homeostasis. Science (New York, N.Y.). 364: 1179-1184. PMID 31221858 DOI: 10.1126/Science.Aaw7479  0.635
2019 Roberts AW, Popov LM, Mitchell G, Ching KL, Licht DJ, Golovkine G, Barton GM, Cox JS. Cas9 conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond. Elife. 8. PMID 31204998 DOI: 10.7554/Elife.45957  0.589
2019 Walsh CM, Hill RZ, Schwendinger-Schreck J, Deguine J, Brock EC, Kucirek N, Rifi Z, Wei J, Gronert K, Brem RB, Barton GM, Bautista DM. Author response: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis Elife. DOI: 10.7554/Elife.48448.Sa2  0.319
2019 Kreuk LS, Koch MA, Slayden LC, Lind NA, Chu S, Savage HP, Kantor AB, Baumgarth N, Barton GM. Author response: B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota Elife. DOI: 10.7554/Elife.47015.028  0.442
2019 Roberts AW, Popov LM, Mitchell G, Ching KL, Licht DJ, Golovkine G, Barton GM, Cox JS. Author response: Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond Elife. DOI: 10.7554/Elife.45957.012  0.345
2019 Pestal K, Barton GM. Abstract B179: The regulation of silent apoptotic cell-clearance in tissue-resident macrophages Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B179  0.428
2018 Price AE, Shamardani K, Lugo KA, Deguine J, Roberts AW, Lee BL, Barton GM. A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns. Immunity. PMID 30170812 DOI: 10.1016/J.Immuni.2018.07.016  0.68
2017 Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM. Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. PMID 29150239 DOI: 10.1016/J.Immuni.2017.10.006  0.619
2017 Deguine J, Wei J, Barbalat R, Gronert K, Barton GM. Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production. Journal of Immunology (Baltimore, Md. : 1950). PMID 28219890 DOI: 10.4049/Jimmunol.1601465  0.676
2016 Majer O, Liu B, Barton GM. Nucleic acid-sensing TLRs: trafficking and regulation. Current Opinion in Immunology. 44: 26-33. PMID 27907816 DOI: 10.1016/J.Coi.2016.10.003  0.684
2016 Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM. Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life. Cell. 165: 827-41. PMID 27153495 DOI: 10.1016/J.Cell.2016.04.055  0.633
2016 Newman ZR, Young JM, Ingolia NT, Barton GM. Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903634 DOI: 10.1073/Pnas.1518976113  0.69
2016 Majer O, Liu B, Lee AY, Barton G. Abstract B130: Dysregulated Toll-like receptor responses as an oncogenic driver Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B130  0.657
2015 Kagan JC, Barton GM. Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harbor Perspectives in Biology. 7: a016253. PMID 25395297 DOI: 10.1101/Cshperspect.A016253  0.664
2014 Deguine J, Barton GM. MyD88: a central player in innate immune signaling. F1000prime Reports. 6: 97. PMID 25580251 DOI: 10.12703/P6-97  0.608
2014 Han SJ, Melichar HJ, Coombes JL, Chan SW, Koshy AA, Boothroyd JC, Barton GM, Robey EA. Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii. Immunology and Cell Biology. 92: 872-81. PMID 25155465 DOI: 10.1038/Icb.2014.70  0.638
2014 Sivick KE, Arpaia N, Reiner GL, Lee BL, Russell BR, Barton GM. Toll-like receptor-deficient mice reveal how innate immune signaling influences Salmonella virulence strategies. Cell Host & Microbe. 15: 203-13. PMID 24528866 DOI: 10.1016/J.Chom.2014.01.013  0.675
2014 Lee BL, Barton GM. Trafficking of endosomal Toll-like receptors. Trends in Cell Biology. 24: 360-9. PMID 24439965 DOI: 10.1016/J.Tcb.2013.12.002  0.678
2013 Koch MA, Barton GM. TLR5 stops commensals in their tracks. Cell Host & Microbe. 14: 488-90. PMID 24237694 DOI: 10.1016/J.Chom.2013.10.015  0.595
2013 Deguine J, Lee BL, Newman ZR, Barton GM. No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. Nature Immunology. 14: 1101-2. PMID 24145778 DOI: 10.1038/Ni.2733  0.64
2013 Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM. UNC93B1 mediates differential trafficking of endosomal TLRs. Elife. 2: e00291. PMID 23426999 DOI: 10.7554/Elife.00291  0.64
2013 Arpaia N, Barton GM. The impact of Toll-like receptors on bacterial virulence strategies. Current Opinion in Microbiology. 16: 17-22. PMID 23290772 DOI: 10.1016/J.Mib.2012.11.004  0.655
2013 Lim K, Barton GM, Staudt LM. Abstract 2332: OncogenicMYD88mutants require Toll-like receptors. Cancer Research. 73: 2332-2332. DOI: 10.1158/1538-7445.Am2013-2332  0.501
2012 Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, ... Barton GM, et al. Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host & Microbe. 11: 306-18. PMID 22423970 DOI: 10.1016/J.Chom.2012.02.002  0.685
2012 Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM. Author response: UNC93B1 mediates differential trafficking of endosomal TLRs Elife. DOI: 10.7554/Elife.00291.013  0.455
2011 Arpaia N, Barton GM. Toll-like receptors: key players in antiviral immunity. Current Opinion in Virology. 1: 447-54. PMID 22440908 DOI: 10.1016/J.Coviro.2011.10.006  0.689
2011 Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 147: 868-80. PMID 22078883 DOI: 10.1016/J.Cell.2011.09.051  0.673
2011 Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM. Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation. Immunity. 35: 721-32. PMID 22078797 DOI: 10.1016/J.Immuni.2011.10.009  0.683
2011 Pezda AC, Penn A, Barton GM, Coscoy L. Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus. Journal of Immunology (Baltimore, Md. : 1950). 187: 887-96. PMID 21666062 DOI: 10.4049/Jimmunol.1003737  0.642
2011 Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. The Journal of Experimental Medicine. 208: 643-51. PMID 21402738 DOI: 10.1084/Jem.20100682  0.687
2011 Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM, Jones MB, Dracheva T, Peterson SN, Monack DM, Barton GM. TLR signaling is required for Salmonella typhimurium virulence. Cell. 144: 675-88. PMID 21376231 DOI: 10.1016/J.Cell.2011.01.031  0.674
2011 Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic acid recognition by the innate immune system. Annual Review of Immunology. 29: 185-214. PMID 21219183 DOI: 10.1146/Annurev-Immunol-031210-101340  0.678
2011 Ewald SE, Barton GM. Nucleic acid sensing Toll-like receptors in autoimmunity. Current Opinion in Immunology. 23: 3-9. PMID 21146971 DOI: 10.1016/J.Coi.2010.11.006  0.688
2010 Engel A, Barton GM. Compartment-specific control of signaling from a DNA-sensing immune receptor. Science Signaling. 3: pe45. PMID 21119105 DOI: 10.1126/Scisignal.3150Pe45  0.69
2010 Barbalat R, Barton GM. MicroRNAs and LPS: developing a relationship in the neonatal gut. Cell Host & Microbe. 8: 303-4. PMID 20951963 DOI: 10.1016/J.Chom.2010.10.001  0.575
2010 Engel A, Barton GM. Unfolding new roles for XBP1 in immunity. Nature Immunology. 11: 365-7. PMID 20404847 DOI: 10.1038/Ni0510-365  0.661
2010 Barbalat R, Lau L, Locksley RM, Barton GM. Erratum: Corrigendum: Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands Nature Immunology. 11: 543-543. DOI: 10.1038/ni0610-543c  0.613
2009 Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nature Immunology. 10: 1200-7. PMID 19801985 DOI: 10.1038/Ni.1792  0.709
2009 Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nature Reviews. Immunology. 9: 535-42. PMID 19556980 DOI: 10.1038/Nri2587  0.687
2008 Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 456: 658-62. PMID 18820679 DOI: 10.1038/Nature07405  0.703
2008 Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunology. 9: 310-8. PMID 18300366 DOI: 10.1038/Ni1558  0.599
2008 Barton GM. A calculated response: control of inflammation by the innate immune system. The Journal of Clinical Investigation. 118: 413-20. PMID 18246191 DOI: 10.1172/Jci34431  0.669
2007 Barton GM. Viral recognition by Toll-like receptors. Seminars in Immunology. 19: 33-40. PMID 17336545 DOI: 10.1016/J.Smim.2007.01.003  0.67
2006 Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nature Immunology. 7: 49-56. PMID 16341217 DOI: 10.1038/Ni1280  0.671
2004 Barton GM, Medzhitov R. Toll signaling: RIPping off the TNF pathway. Nature Immunology. 5: 472-4. PMID 15116112 DOI: 10.1038/Ni0504-472  0.626
2003 Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science (New York, N.Y.). 300: 1524-5. PMID 12791976 DOI: 10.1126/Science.1085536  0.705
2003 Barton GM, Medzhitov R. Linking Toll-like receptors to IFN-alpha/beta expression. Nature Immunology. 4: 432-3. PMID 12719735 DOI: 10.1038/Ni0503-432  0.58
2002 Barton GM, Medzhitov R. Toll-like receptors and their ligands Current Topics in Microbiology and Immunology. 270: 81-92. PMID 12467245 DOI: 10.1007/978-3-642-59430-4_5  0.701
2002 Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 420: 329-33. PMID 12447442 DOI: 10.1038/Nature01180  0.7
2002 Barton GM, Medzhitov R. Retroviral delivery of small interfering RNA into primary cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 14943-5. PMID 12417750 DOI: 10.1073/Pnas.242594499  0.528
2002 Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA, Rudensky AY. Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 6937-42. PMID 12011451 DOI: 10.1073/Pnas.102645699  0.744
2002 Barton GM, Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Current Opinion in Immunology. 14: 380-3. PMID 11973138 DOI: 10.1016/S0952-7915(02)00343-6  0.683
2001 Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nature Immunology. 2: 947-50. PMID 11547333 DOI: 10.1038/Ni712  0.675
2001 Horng T, Barton GM, Medzhitov R. TIRAP: An adapter molecule in the Toll signaling pathway Nature Immunology. 2: 835-841. PMID 11526399 DOI: 10.1038/Ni0901-835  0.666
2001 Wong P, Barton GM, Forbush KA, Rudensky AY. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands Journal of Experimental Medicine. 193: 1179-1187. PMID 11369789 DOI: 10.1084/Jem.193.10.1179  0.744
1999 Barton GM, Rudensky AY. Evaluating peptide repertoires within the context of thymocyte development Seminars in Immunology. 11: 417-422. PMID 10625595 DOI: 10.1006/Smim.1999.0199  0.684
1999 Barton GM, Rudensky AY. Requirement for diverse, low-abundance peptides in positive selection of T cells Science. 283: 67-70. PMID 9872742 DOI: 10.1126/Science.283.5398.67  0.669
1998 Barton GM, Rudensky AY. An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II αβ dimers and facilitates highly efficient peptide loading International Immunology. 10: 1159-1165. PMID 9723702 DOI: 10.1093/Intimm/10.8.1159  0.634
1998 Alberola-lla J, Levin SD, Barton G, Forbush K, Zon LI, Perlmutter RM. Analysis of the pole of MKK-4/Sek-1 in T cell development and apoptosis International Immunology. 10: 1077-1082. PMID 9723693 DOI: 10.1093/Intimm/10.8.1077  0.495
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